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JOURNAL ARTICLE
Mateusz P Plesniak, Emilia K Taylor, Frederik Eisele, Christopher M B K Kourra, Iacovos N Michaelides, Alice Oram, Johan Wernevik, Zulma Santisteban Valencia, Hannah Rowbottom, Nadia Mann, Linda Fredlund, Valentyna Pivnytska, Anna Novén, Mohammad Pirmoradian, Thomas Lundbäck, R Ian Storer, Mariell Pettersson, Gian M De Donatis, Marie Rehnström
Precise length, shape, and linker attachment points are all integral components to designing efficacious proteolysis targeting chimeras (PROTACs). Due to the synthetic complexity of these heterobifunctional degraders and the difficulty of computational modeling to aid PROTAC design, the exploration of structure-activity relationships remains mostly empirical, which requires a significant investment of time and resources. To facilitate rapid hit finding, we developed capabilities for PROTAC parallel synthesis and purification by harnessing an array of preformed E3-ligand-linker intermediates...
December 14, 2023: ACS Medicinal Chemistry Letters
#2
JOURNAL ARTICLE
Irene Kyomuhangi, Andrew Andrada, Zhiyuan Mao, Derek Pollard, Christina Riley, Adam Bennett, Busiku Hamainza, Hannah Slater, Justin Millar, John M Miller, Thomas P Eisele, Kafula Silumbe
BACKGROUND: In 2020, the Zambia National Malaria Elimination Centre targeted the distribution of long-lasting insecticidal nets (LLINs) and indoor-residual spraying (IRS) campaigns based on sub-district micro-planning, where specified geographical areas at the health facility catchment level were assigned to receive either LLINs or IRS. Using data from the 2021 Malaria Indicator Survey (MIS), the objectives of this analysis were to (1) assess how well the micro-planning was followed in distributing LLINs and IRS, (2) investigate factors that contributed to whether households received what was planned, and (3) investigate how overall coverage observed in the 2021 MIS compared to the 2018 MIS conducted prior to micro-planning...
November 30, 2023: Malaria Journal
#3
JOURNAL ARTICLE
Joshua Yukich, Thomas P Eisele, Feiko terKuile, Ruth Ashton, Sarah Staedke, Angela F Harris, Paul C D Johnson, Sophie Sarrassat, Maia Lesosky, John Bradley, Immo Kleinschmidt, Megan Littrell
This manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate the efficacy of attractive targeted sugar baits (ATSB) described in an already published protocol. The master SAP contains an overarching plan for all three trials, which can be adapted to trial-specific circumstances. The primary objective of the trials is to evaluate the efficacy of ATSB in the presence of universal vector control coverage with insecticide-treated nets (ITN) or indoor residual spraying (IRS) after two transmission seasons on clinical malaria incidence as compared with universal vector control coverage with ITN or IRS alone...
November 29, 2023: Trials
#4
JOURNAL ARTICLE
Paul Hutchinson, Rose Zulliger, Jessica K Butts, Balthazar Candrinho, Abu Saifodine, Thomas P Eisele, Josh Yukich
BACKGROUND: Malaria is endemic throughout Mozambique, contributing significantly to the country's burden of disease. Prompt and effective treatment for fevers in children can limit the mortality and morbidity impacts of the disease but many children in the country are not taken for formal care when ill. Using an ideational model of behaviour, this study assesses the magnitude of the relationships for potential drivers of care-seeking, including interpersonal communication, malaria messaging, and knowledge and attitudes about malaria, with actual care-seeking behaviours for under-five children with fever in Magoé district, Mozambique...
September 21, 2023: Malaria Journal
#5
JOURNAL ARTICLE
Meytal Guller, Dylan J Cooper, Hosam Alkhatib, Aditya Suru, Angelo Blancaflor, Christopher A Maroun, Tristan Tham, Hailey Allen, Eden Mazzara, Jerin Thomas, Neha Amin, Evan Wu, David W Eisele, Carole Fakhry, Drew Pardoll, Tanguy Y Seiwert, Gangcai Zhu, Rajarsi Mandal
OBJECTIVES: To explore the impact of pre-existing comorbidities on immunotherapy response, overall and progression-free survival, and immune-related adverse events (irAEs) of patients with advanced head and neck cancer (HNC) treated with immunotherapy. PATIENTS AND METHODS: Ninety-three patients treated with immunotherapy were identified and stratified into comorbidity absent or present (CCI < 1 and CCI ≥ 1, respectively) cohorts, and clinical outcomes were compared between these two groups...
September 8, 2023: Head & Neck
#6
JOURNAL ARTICLE
Maëlle Kapfer, Bjarke S Jessen, Megan E Eisele, Matthew Fu, Dorte R Danielsen, Thomas P Darlington, Samuel L Moore, Nathan R Finney, Ariane Marchese, Valerie Hsieh, Paulina Majchrzak, Zhihao Jiang, Deepnarayan Biswas, Pavel Dudin, José Avila, Kenji Watanabe, Takashi Taniguchi, Søren Ulstrup, Peter Bøggild, P J Schuck, Dmitri N Basov, James Hone, Cory R Dean
Moiré superlattices in twisted two-dimensional materials have generated tremendous excitement as a platform for achieving quantum properties on demand. However, the moiré pattern is highly sensitive to the interlayer atomic registry, and current assembly techniques suffer from imprecise control of the average twist angle, spatial inhomogeneity in the local twist angle, and distortions caused by random strain. We manipulated the moiré patterns in hetero- and homobilayers through in-plane bending of monolayer ribbons, using the tip of an atomic force microscope...
August 11, 2023: Science
#7
JOURNAL ARTICLE
Nerea Ruiz-Solaní, Jose Salguero-Linares, Laia Armengot, Jaime Santos, Irantzu Pallarès, Katarina P van Midden, Ujjal J Phukkan, Seda Koyuncu, Júlia Borràs-Bisa, Liang Li, Crina Popa, Frederik Eisele, Anna Maria Eisele-Bürger, Sandra Malgrem Hill, Emilio Gutiérrez-Beltrán, Thomas Nyström, Marc Valls, Ernesto Llamas, David Vilchez, Marina Klemenčič, Salvador Ventura, Nuria S Coll
Stress granules (SGs) are highly conserved cytoplasmic condensates that assemble in response to stress and contribute to maintaining protein homeostasis. These membraneless organelles are dynamic, disassembling once the stress is no longer present. Persistence of SGs due to mutations or chronic stress has been often related to age-dependent protein-misfolding diseases in animals. Here, we find that the metacaspase MC1 is dynamically recruited into SGs upon proteotoxic stress in Arabidopsis (Arabidopsis thaliana)...
July 1, 2023: Plant Cell
#8
JOURNAL ARTICLE
Karen E S Hamre, Amber M Dismer, Eric Rogier, Lotus L van den Hoogen, John Williamson, Nishant Kishore, Anyess Travers, Kathleen McGee, Baby Pierre, Bernadette Fouché, Daniel Impoinvil, Kathleen Holmes, Gillian Stresman, Thomas Druetz, Thomas P Eisele, Chris Drakeley, Jean Frantz Lemoine, Michelle A Chang
Targeting malaria interventions in elimination settings where transmission is heterogeneous is essential to ensure the efficient use of resources. Identifying the most important risk factors among persons experiencing a range of exposure can facilitate such targeting. A cross-sectional household survey was conducted in Artibonite, Haiti, to identify and characterize spatial clustering of malaria infections. Household members (N = 21,813) from 6,962 households were surveyed and tested for malaria. An infection was defined as testing positive for Plasmodium falciparum by either a conventional or novel highly sensitive rapid diagnostic test...
June 5, 2023: American Journal of Tropical Medicine and Hygiene
#9
JOURNAL ARTICLE
Michelle A Chang, Daniel Impoinvil, Karen E S Hamre, Paul-Emile Dalexis, Jean-Baptiste Mérilien, Amber M Dismer, Bernadette Fouché, Luccene Desir, Kathleen Holmes, Willy Lafortune, Camelia Herman, Eric Rogier, Gregory S Noland, Alyssa J Young, Thomas Druetz, Ruth Ashton, Thomas P Eisele, Justin Cohen, Lotus van den Hoogen, Gillian Stresman, Chris Drakeley, Emilie Pothin, Ewan Cameron, Katherine E Battle, John Williamson, Marc-Aurèle Telfort, Jean Frantz Lemoine
For a malaria elimination strategy, Haiti's National Malaria Control Program piloted a mass drug administration (MDA) with indoor residual spraying (IRS) in 12 high-transmission areas across five communes after implementing community case management and strengthened surveillance. The MDA distributed sulfadoxine-pyrimethamine and single low-dose primaquine to eligible residents during house visits. The IRS campaign applied pirimiphos-methyl insecticide on walls of eligible houses. Pre- and post-campaign cross-sectional surveys were conducted to assess acceptability, feasibility, drug safety, and effectiveness of the combined interventions...
May 9, 2023: American Journal of Tropical Medicine and Hygiene
#10
JOURNAL ARTICLE
Ruth A Ashton, Busiku Hamainza, Chris Lungu, Marie-Reine I Rutagwera, Travis Porter, Adam Bennett, Michael Hainsworth, Sarah Burnett, Kafula Silumbe, Hannah Slater, Thomas P Eisele, John M Miller
BACKGROUND: Community case management of malaria (CCM) has been expanded in many settings, but there are limited data describing the impact of these services in routine implementation settings or at large scale. Zambia has intensively expanded CCM since 2013, whereby trained volunteer community health workers (CHW) use rapid diagnostic tests and artemether-lumefantrine to diagnose and treat uncomplicated malaria. METHODS: This retrospective, observational study explored associations between changing malaria service point (health facility or CHW) density per 1000 people and severe malaria admissions or malaria inpatient deaths by district and month in a dose-response approach, using existing routine and programmatic data...
March 17, 2023: Malaria Journal
#11
JOURNAL ARTICLE
Joshua O Yukich, Paul Hutchinson, Baltazar Candrinho, Jessica Butts, Filipe Murimirgua, Thomas P Eisele, Rose Zulliger
BACKGROUND: Insecticide treated bed nets (ITN) are considered a core malaria vector control tool by the WHO and are the main contributor to the large decline in malaria burden in sub-Saharan Africa over the past 20 years, but they are less effective if they are not broadly and regularly used. ITN use may depend on factors including temperature, relative humidity, mosquito density, seasonality, as well as ideational or psychosocial factors including perceptions of nets and perceptions of net use behaviours...
December 17, 2022: Malaria Journal
#12
JOURNAL ARTICLE
Alicia Jaramillo-Underwood, Daniel Impoinvil, Alice Sutcliff, Karen E S Hamre, Vena Joseph, Lotus van den Hoogen, Jean Frantz Lemoine, Ruth A Ashton, Michelle A Chang, Alexandre Existe, Jacques Boncy, Chris Drakeley, Gillian Stresman, Thomas Druetz, Thomas Eisele, Eric Rogier
Serological data can provide estimates of human exposure to both malaria vector and parasite based on antibody responses. A multiplex bead-based assay was developed to simultaneously detect IgG to Anopheles albimanus salivary gland extract (SGE) and 23 Plasmodium falciparum antigens among 4,185 participants enrolled in Artibonite department, Haiti in 2017. Logistic regression adjusted for participant- and site-level covariates and found children under 5 years and 6-15 years old had 3.7- and 5.4-fold increase in odds, respectively, of high anti-SGE IgG compared to participants >15 years...
June 17, 2022: Journal of Infectious Diseases
#13
EDITORIAL
Thomas P Eisele, Laurence Slutsker
New England Journal of Medicine, Volume 386, Issue 5, Page 490-491, February 2022.
February 3, 2022: New England Journal of Medicine
#14
JOURNAL ARTICLE
Maria Pino, Talha Abid, Susan Pereira Ribeiro, Venkata Viswanadh Edara, Katharine Floyd, Justin C Smith, Muhammad Bilal Latif, Gabriela Pacheco-Sanchez, Debashis Dutta, Shelly Wang, Sanjeev Gumber, Shannon Kirejczyk, Joyce Cohen, Rachelle L Stammen, Sherrie M Jean, Jennifer S Wood, Fawn Connor-Stroud, Jeroen Pollet, Wen-Hsiang Chen, Junfei Wei, Bin Zhan, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, Neeta Shenvi, Kirk Easley, Daniela Weiskopf, Alessandro Sette, Justin Pollara, Dieter Mielke, Hongmei Gao, Nathan Eisel, Celia C LaBranche, Xiaoying Shen, Guido Ferrari, Georgia D Tomaras, David C Montefiori, Rafick P Sekaly, Thomas H Vanderford, Mark A Tomai, Christopher B Fox, Mehul S Suthar, Pamela A Kozlowski, Peter J Hotez, Mirko Paiardini, Maria Elena Bottazzi, Sudhir Pai Kasturi
Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low and middle-income countries. Here, we report the efficacy of a rapidly scalable, novel yeast expressed SARS-CoV-2 specific receptor-binding domain (RBD) based vaccine in rhesus macaques. We formulated the RBD immunogen in alum, a licensed and an emerging alum adsorbed TLR-7/8 targeted, 3M-052-alum adjuvants. The RBD+3M-052-alum adjuvanted vaccine promoted better RBD binding and effector antibodies, higher CoV-2 neutralizing antibodies, improved Th1 biased CD4+T cell reactions, and increased CD8+ T cell responses when compared to the alum-alone adjuvanted vaccine...
July 15, 2021: Science Immunology
#15
JOURNAL ARTICLE
Thomas Druetz, Gillian Stresman, Ruth A Ashton, Vena Joseph, Lotus van den Hoogen, Matt Worges, Karen E S Hamre, Carl Fayette, Frank Monestime, Daniel Impoinvil, Eric Rogier, Michelle A Chang, Jean Frantz Lemoine, Chris Drakeley, Thomas P Eisele
BACKGROUND: Haiti is planning targeted interventions to accelerate progress towards malaria elimination. In the most affected Department (Grande-Anse), a combined mass drug administration (MDA) and indoor residual spraying (IRS) campaign was launched in October 2018. This study assessed the intervention effectiveness in reducing P. falciparum prevalence. METHODS: An ecological quasi-experimental study was designed, using a pre- and post-test with nonrandomized control group...
May 16, 2021: Journal of Infectious Diseases
#16
JOURNAL ARTICLE
Lotus L van den Hoogen, Camelia Herman, Jacquelin Présumé, Ithamare Romilus, Gina Mondélus, Tamara Elismé, Alexandre Existe, Jacques Boncy, Vena Joseph, Gillian Stresman, Kevin K A Tetteh, Chris Drakeley, Michelle A Chang, Jean F Lemoine, Thomas P Eisele, Eric Rogier, Ruth A Ashton
Haiti is targeting malaria elimination by 2025. The Grand'Anse department in southwestern Haiti experiences one-third to half of all nationally reported Plasmodium falciparum cases. Although there are historical reports of Plasmodium vivax and Plasmodium malariae, today, non-falciparum infections would remain undetected because of extensive use of falciparum-specific histidine-rich protein 2 (HRP2) rapid diagnostic tests (RDT) at health facilities. A recent case-control study was conducted in Grand'Anse to identify risk factors for P...
April 5, 2021: American Journal of Tropical Medicine and Hygiene
#17
JOURNAL ARTICLE
Joseph Keating, Joshua O Yukich, John M Miller, Sara Scates, Busiku Hamainza, Thomas P Eisele, Adam Bennett
BACKGROUND: Widespread insecticide resistance to pyrethroids could thwart progress towards elimination. Recently, the World Health Organization has encouraged the use of non-pyrethroid insecticides to reduce the spread of insecticide resistance. An electronic tool for implementing and tracking coverage of IRS campaigns has recently been tested (mSpray), using satellite imagery to improve the accuracy and efficiency of the enumeration process. The purpose of this paper is to retrospectively analyse cross-sectional observational data to provide evidence of the epidemiological effectiveness of having introduced Actellic 300CS and the mSpray platform into IRS programmes across Zambia...
April 1, 2021: Malaria Journal
#18
JOURNAL ARTICLE
Annette B Vogel, Isis Kanevsky, Ye Che, Kena A Swanson, Alexander Muik, Mathias Vormehr, Lena M Kranz, Kerstin C Walzer, Stephanie Hein, Alptekin Güler, Jakob Loschko, Mohan S Maddur, Ayuko Ota-Setlik, Kristin Tompkins, Journey Cole, Bonny G Lui, Thomas Ziegenhals, Arianne Plaschke, David Eisel, Sarah C Dany, Stephanie Fesser, Stephanie Erbar, Ferdia Bates, Diana Schneider, Bernadette Jesionek, Bianca Sänger, Ann-Kathrin Wallisch, Yvonne Feuchter, Hanna Junginger, Stefanie A Krumm, André P Heinen, Petra Adams-Quack, Julia Schlereth, Stefan Schille, Christoph Kröner, Ramón de la Caridad Güimil Garcia, Thomas Hiller, Leyla Fischer, Rani S Sellers, Shambhunath Choudhary, Olga Gonzalez, Fulvia Vascotto, Matthew R Gutman, Jane A Fontenot, Shannan Hall-Ursone, Kathleen Brasky, Matthew C Griffor, Seungil Han, Andreas A H Su, Joshua A Lees, Nicole L Nedoma, Ellene H Mashalidis, Parag V Sahasrabudhe, Charles Y Tan, Danka Pavliakova, Guy Singh, Camila Fontes-Garfias, Michael Pride, Ingrid L Scully, Tara Ciolino, Jennifer Obregon, Michal Gazi, Ricardo Carrion, Kendra J Alfson, Warren V Kalina, Deepak Kaushal, Pei-Yong Shi, Thorsten Klamp, Corinna Rosenbaum, Andreas N Kuhn, Özlem Türeci, Philip R Dormitzer, Kathrin U Jansen, Ugur Sahin
A safe and effective vaccine against COVID-19 is urgently needed in quantities that are sufficient to immunize large populations. Here we report the preclinical development of two vaccine candidates (BNT162b1 and BNT162b2) that contain nucleoside-modified messenger RNA that encodes immunogens derived from the spike glycoprotein (S) of SARS-CoV-2, formulated in lipid nanoparticles. BNT162b1 encodes a soluble, secreted trimerized receptor-binding domain (known as the RBD-foldon). BNT162b2 encodes the full-length transmembrane S glycoprotein, locked in its prefusion conformation by the substitution of two residues with proline (S(K986P/V987P); hereafter, S(P2) (also known as P2 S))...
April 2021: Nature
#19
JOURNAL ARTICLE
Lungowe Sitali, Mulenga C Mwenda, John M Miller, Daniel J Bridges, Moonga B Hawela, Busiku Hamainza, Mutinta Mudenda-Chilufya, Elizabeth Chizema-Kawesha, Rachel Daniels, Thomas P Eisele, Audun H Nerland, James Chipeta, Bernt Lindtjorn
This article describes data on selected resistance markers for antimalarial drugs used in Zambia. Antimalarial drug resistance has hindered the progress in the control and elimination of malaria. Blood samples were collected during a cross-sectional household survey, conducted during the peak malaria transmission, April to May of 2017. Dried blood spots were collected during the survey and transported to a laboratory for analysis. The analysed included polymerase chain reaction (PCR) followed by high resolution melt (HRM) for mutations associated with Sulfadoxine-pyrimethamine resistance in the Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and P...
February 2021: Data in Brief
#20
JOURNAL ARTICLE
Seydou Fomba, Diakalia Koné, Bakary Doumbia, Diadier Diallo, Thomas Druetz, Lia Florey, Thomas P Eisele, Erin Eckert, Jules Mihigo, Ruth A Ashton
BACKGROUND: Prompt and effective malaria diagnosis and treatment is a cornerstone of malaria control. Case management guidelines recommend confirmatory testing of suspected malaria cases, then prescription of specific drugs for uncomplicated malaria and for severe malaria. This study aims to describe case management practices for children aged 1-59 months seeking treatment with current or recent fever from public and private, rural and urban health providers in Mali. METHODS: Data were collected at sites in Sikasso Region and Bamako...
December 9, 2020: BMC Public Health
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