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https://www.readbyqxmd.com/read/27888519/antibiotics-in-eosinophilic-chronic-rhinosinusitis-rethinking-maximal-antimicrobial-medical-therapy
#1
Ceren Günel, Benjamin S Bleier, Ibrahim Meteoglu
OBJECTIVES/HYPOTHESIS: Eosinophilic chronic rhinosinusitis (eCRS) has recently been recognized as a CRS subtype characterized by inflammation rather than chronic infection. Consequently, the role of antibiotics as a component of maximal medical therapy for eCRS has been called into question. The purpose of this study was to investigate whether the use of antibiotics, which lack any secondary anti-inflammatory properties, are useful in the treatment of eCRS. STUDY DESIGN: Prospective individual cohort study...
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27882078/debridement-in-chronic-osteomyelitis-with-benign-osteopetrosis-a-case-report
#2
Yu-Ping Liu, Xiang-Hua Lin, Man-Yun Yan, Bao-Quan Lin, Ming-Ying Zhuo
Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27879303/smooth-muscle-tumour-of-uncertain-malignant-potential-smtump-in-the-nasal-cavity-an-incidental-finding
#3
Dipak Ranjan Nayak, Asheesh Dora Ghanpur, Apoorva N Reddy, Swati Sharma
Sino-nasal smooth muscle tumours of uncertain malignant potential (SMTUMP) are very rare neoplasms of mesenchymal origin with features in between a benign leiomyoma and a leiomyosarcoma. We report a rare case of SMTUMP in a 44-year-old woman, who presented with vague symptoms of pharyngitis. Nasal endoscopy revealed a smooth mass in left nasal cavity. Contrast-enhanced CT and MRI scans showed features likely to be inverted papilloma or olfactory neuroblastoma or meningioma. Excision was planned and intraoperatively, frozen section revealed a probable spindle cell lesion...
November 22, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27863163/surgical-therapy-vs-continued-medical-therapy-for-medically-refractory-chronic-rhinosinusitis-a-systematic-review-and-meta-analysis
#4
Zara M Patel, Andrew Thamboo, Luke Rudmik, Jayakar V Nayak, Timothy L Smith, Peter H Hwang
BACKGROUND: The currently accepted treatment paradigm of treating chronic rhinosinusitis (CRS) first with appropriate medical therapy (AMT) and then with surgery if patients are refractory to AMT, has been criticized for lack of evidence. The objective of this study was to reassess the literature and establish the highest level of evidence possible regarding further management of CRS patients refractory to AMT. METHODS: This study was a systematic review (SR) with meta-analysis (MA)...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27860447/fluorescein-guided-intraoperative-endoscopy-in-patients-with-hereditary-hemorrhagic-telangiectasia-first-impressions
#5
Fabio Pagella, Alessandro Pusateri, Dario Zaccari, Daniele Bongetta, Cesare Zoia, Giuseppe Spinozzi, Carla Olivieri, Elina Matti
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease that results in mucocutaneous telangiectasias and arteriovenous visceral malformations. Nasal telangiectasias lead to recurrent epistaxis, which affects up to 96% of patients. Different morphologic classifications and methods of visualization of nasal lesions have been described in the literature. We developed a new method of intraoperative endoscopy based on the intravenous administration of fluorescein...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27860385/paranasal-sinus-size-is-decreased-in-cftr-heterozygotes-with-chronic-rhinosinusitis
#6
Joshua B Calton, Pradeep C Koripella, Amanda L Willis, Christopher H Le, Alexander G Chiu, Eugene H Chang
BACKGROUND: Cystic fibrosis (CF) heterozygotes with a single mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are at significantly higher risk to develop chronic rhinosinusitis (CRS). However the reasons why remain unknown. We tested the hypothesis that CFTR heterozygotes would have smaller sinus volumes than healthy controls. To exclude sinus disease as a confounding factor we also assessed paranasal sinus volume in those with CRS, but without known CFTR mutations...
November 17, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27859303/prevalence-of-polyp-recurrence-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-with-nasal-polyposis
#7
Adam S DeConde, Jess C Mace, Joshua M Levy, Luke Rudmik, Jeremiah A Alt, Timothy L Smith
OBJECTIVES/HYPOTHESIS: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued medical therapy is commonly elected by medically recalcitrant, symptomatic patients. The objective was to evaluate the prevalence of nasal polyp recurrence up to 18 months after endoscopic sinus surgery (ESS) with congruent continuing medical management. STUDY DESIGN: Prospective, multicenter cohort of adult patients undergoing ESS for medically recalcitrant CRSwNP performed between August 2004 and February 2015...
November 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853012/outcomes-of-endoscopic-dacryocystorhinostomy-experience-of-a-fellowship-trainee-at-a-tertiary-care-center
#8
Saurabh Kamal, Mohammad Javed Ali, Akshay Gopinathan Nair
AIM: The study aims to report a single trainee's experience of learning and performing endoscopic endonasal dacryocystorhinostomy (En-DCR). SETTINGS AND DESIGN: This study was a retrospective, interventional case series. SUBJECTS AND METHODS: Fifty-four eyes of fifty patients presenting at a tertiary eye care center over 1 year were included in the study. All cases underwent endoscopic DCR with mitomycin-C and silicone intubation. The parameters studied included demographics, clinical features, intraoperative details, and postoperative ostium evaluation...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27833876/a-short-term-subjective-and-objective-analysis-of-modified-endoscopic-lothrop-s-procedure-and-its-functional-outcome-our-experience
#9
D R Nayak, K Pai, S Nair, B Ramaswamy, H Sabhahit
To study the short-term functional outcomes of the endoscopic modified Lothrop procedure with well defined subjective and objective criteria. It's a retrospective cohort study with chart review carried out at a tertiary referral center. 31 patients with chronic frontal sinusitis who underwent endoscopic modified Lothrop's procedure with uncinate preservation during the period Jan 2011-2014 were followed up for a period of minimum 6 months. Assessment was done post-operatively based on subjective severity score and Kennedy's 5 point endoscopic criteria...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27792098/sinus-disventilation-and-atrophy-of-the-upper-maxilla-a-combined-surgical-approach-is-possible
#10
Orlando Cipriani, Valentino Vellone, Paolo Arangio, Fabio Della Rocca
This study aims to assess the effectiveness and reliability of a new combined approach to treat the maxillary atrophy and chronic rhinosinusitis (CRS) and other rhino-sinusal pathologies. This 1-step procedure consisting functional endoscopic sinus surgery (FESS) and maxillary sinus-lift with simultaneous implant placement for patients with a severe reabsorbed maxillary bone and sinuses' disease. In case of disventilation and maxillary sinuses flogosis, the mucociliary clearance and physiological ventilation have to be aided, in order to make a safer and predictable sinus-lift surgery...
October 27, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27789155/guidelines-of-the-french-society-of-otorhinolaryngology-sforl-first-line-treatment-of-epistaxis-in-adults
#11
E Bequignon, B Vérillaud, L Robard, J Michel, V Prulière Escabasse, L Crampette, O Malard
OBJECTIVES: The authors present the guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (SFORL) on first-line treatment of epistaxis in adults. METHODS: A multidisciplinary work-group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, based on the articles retrieved and the group members' individual experience. They were then read over by an editorial group independent of the work-group. The guidelines were graded as A, B, C or expert opinion, by decreasing level of evidence...
October 24, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27787624/clinical-benefits-of-polyurethane-nasal-packing-in-endoscopic-sinus-surgery
#12
Zalan Piski, Imre Gerlinger, Nelli Nepp, Peter Revesz, Andras Burian, Kornelia Farkas, Laszlo Lujber
The benefits of nasal packing after endoscopic sinus surgery (ESS) are still debated in the literature. Our aims were to evaluate the efficacy, and the clinical effects of a totally degradable nasal dressing used after ESS. Thirty patients with chronic rhinosinusitis with nasal polyps were enrolled in a prospective, randomized, double-blind, controlled study. Every patient underwent ESS and a polyurethane nasal dressing was used in one nasal fossa and the contralateral fossa was left unpacked. The extent of mucosal edema, crust formation, bleeding tendency, presence of synechiae, amount of nasal discharge, and the patency of the ostiomeatal complex (OMC) was evaluated during nasal endoscopy on the first, fourth, and twelfth postoperative weeks...
October 27, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27773560/surgical-resection-of-sinonasal-hemangiopericytoma-involving-anterior-skull-base-case-reports-and-literature-review
#13
Jonathan C Simmonds, Elie E Rebeiz
Hemangiopericytomas are soft tissue tumors composed of pericytic cells that are characterized by their "staghorn" vascular branching and their variable clinical presentation. Fifteen to 25% of all HPC occur in the head and neck, with only 5% found in the nose or paranasal sinuses. Sinonasal hemangiopericytoma (SNHPC) is considered distinct from its soft tissue counterpart - the former showing a more uniform cellular organization, has convincing pericytic differentiation and is associated with a far better prognosis...
September 28, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27760959/-the-efficiency-of-postoperative-endoscopy-for-anastomotic-leakage-after-total-gastrectomy
#14
Masanori Yamada, Koji Nakai, Kentaro Inoue, Takeshi Hijikawa, Hiroaki Kitade, Kazuhiko Yoshioka, Masanori Kon
An 81-year-old man underwent total gastrectomy with Roux-en-Y reconstruction for cardiac cancer in our department. He developed high fever on postoperative day 3, and pathological examination showed WBC and CRP level of 12,000/mL and 29.983mg/dL, respectively. A diagnosis of anastomotic leakage was confirmed using enhanced abdominal CT scanning that demonstrated free air around the esophagojejunalanastomosis after totalgastrectomy. The drainage tube was replaced by a 12 Fr sump tube because of leakage on postoperative day 10...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760096/haemangiopericytoma-like-tumor-of-the-nasal-cavity-treated-by-endoscopy-a-case-report
#15
Bartosz Piszczatowski, Małgorzata Różańska, Andrzej Sieśkiewicz, Joanna Reszeć, Marek Rogowski
Haemangiopericytoma (HPC) is an uncommon, vascular tumor derived from Zimmerman pericytes surrounding blood vessels. HPC constitute around 1% of all tumors of vascular origin and may appear anywhere, 5% of them can be situated in nasal cavity. Tumor location within the head and neck predispose to its benign character and improves prognosis. This case report presents the case of 33-year-old patient with haemangiopericytoma-like tumor of the nasal cavity, presented symptoms of impaired nasal breathing and recurrent epistaxis...
October 19, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27757233/a-rare-nasal-cavity-mass-in-a-child-accessory-middle-turbinate
#16
Andrew Chang, Seckin O Ulualp, Korgun Koral, Maria Veling
OBJECTIVES: The accessory middle turbinate, a rare anatomical variation of the nasal cavity, have been systematically studied in adults. Presence of accessory middle turbinate and its clinical significance in a child has not been reported. We describe clinical appearance and radiologic features of accessory middle turbinate in a child. METHODS: Retrospective chart review. RESULTS: A 3-year-old boy presented to the otolaryngology clinic for evaluation of recurrent epistaxis...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27746841/granulocyte-macrophage-colony-stimulating-factor-production-and-tissue-eosinophilia-in-chronic-rhinitis
#17
Aleksandar Peric, Cveta Spadijer-Mirkovic, Svjetlana Matkovic-Jozin, Ljiljana Jovancevic, Danilo Vojvodic
Introduction Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a strong proinflammatory cytokine that takes part in allergic nasal inflammation as an eosinophil colony-stimulating factor. However, the role of GM-CSF in non-allergic rhinitis has not been fully explored. Objectives The aim of this investigation was to assess the concentration of GM-CSF in nasal secretions of patients with non-allergic rhinitis with eosinophilia syndrome (NARES) in comparison to patients with perennial allergic rhinitis (PAR) and healthy subjects, as well as to assess the relationship with the degree of eosinophilic inflammation and clinical characteristics of the patients...
October 2016: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/27744088/association-of-nasal-mucosal-vascular-alterations-gastrointestinal-arteriovenous-malformations-and-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#18
Snehal R Patel, Shivank Madan, Omar Saeed, Mohammed Algodi, Anne Luke, Marc Gibber, Daniel J Goldstein, Ulrich P Jorde
OBJECTIVES: This study sought to determine whether the nasal mucosa can serve as a surrogate for evaluating arteriovenous malformations (AVMs) related gastrointestinal (GI) bleeding in patients supported by continuous flow left ventricular assist devices (CF LVADs). BACKGROUND: Bleeding from the mucosal surfaces of GI tract, particularly AVMs, is the most common complication of CF LVAD support. The pathophysiology of AVM formation during CF LVAD support is of critical interest yet poorly understood; in large part because of the length and accessibility of the GI tract...
September 29, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27729124/quality-of-life-after-endoscopic-sinus-surgery-in-refractory-pediatric-chronic-rhinosinusitis
#19
Gyanesh Sethi, Arunabha Chakravarti
OBJECTIVE: The present study aims to evaluate the role of Endoscopic Sinus Surgery (ESS) in refractory pediatric Chronic Rhinosinusitis (CRS) and to assess the change in quality of life after ESS. MATERIALS AND METHODS: This prospective interventional study included 35 children (aged between 6 and 12 years) of refractory CRS, not responding to 4 weeks of maximal medical therapy attending the pediatric ENT clinic of a tertiary referral centre. Study period was from November 2013 to March 2016...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27727523/the-importance-of-combined-24-hour-multichannel-intraluminal-impedance-ph-monitoring-in-the-evaluation-of-children-with-suspected-laryngopharyngeal-reflux
#20
I Pavić, I Babić, J Čepin Bogović, I Hojsak
OBJECTIVE: The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in children with suspected laryngopharyngeal reflux (LPR). DESIGN, SETTING AND PARTICIPANTS: A prospective study including children in whom, due to LPR suggestive symptoms, MII-pH monitoring was performed at tertiary medical centre from February 2012 to July 2015. INTERVENTIONS: All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24-hour MII-pH monitoring...
October 11, 2016: Clinical Otolaryngology
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