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https://www.readbyqxmd.com/read/29670409/safinamide-an-add-on-treatment-for-managing-parkinson-s-disease
#1
REVIEW
Thomas Müller
Heterogeneous expression of neurotransmitter deficits results from onset and progression of Parkinson's disease. Intervals, characterized by reappearance of motor and associated certain nonmotor symptoms, determine the end of good tolerability and efficacy of oral levodopa therapy. These "OFF" states result from levodopa pharmacokinetics and disease progression-related deterioration of the central buffering capacity for fluctuations of dopamine levels. This review discusses safinamide as an add-on therapeutic agent in orally levodopa-treated patients with "OFF" phenomena...
2018: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29653075/inhibition-of-semicarbazide-sensitive-amine-oxidase-reduces-atherosclerosis-in-apolipoprotein-e-deficient-mice
#2
Shu-Huei Wang, Tse-Ya Yu, Feng-Chiao Tsai, Chris J Weston, Mao-Shin Lin, Chi-Sheng Hung, Hsien-Li Kao, Yu-I Li, Montse Solé, Mercedes Unzeta, Yuh-Lien Chen, Lee-Ming Chuang, Hung-Yuan Li
Inflammation, oxidative stress, and formation of advanced glycated end products (AGEs) and advanced lipoxidation end products (ALEs) are important for atherosclerosis. Vascular adhesion protein-1 (VAP-1) participates in inflammation and has semicarbazide-sensitive amine oxidase (SSAO) activity, which catalyzes oxidative deamination to produce hydrogen peroxide and aldehydes, leading to generation of AGEs and ALEs. However, the effect of VAP-1/SSAO inhibition on atherosclerosis remains controversial, and no studies used coronary angiography to evaluate if plasma VAP-1/SSAO is a biomarker for coronary artery disease (CAD)...
March 27, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29581294/crystal-structure-of-human-lysyl-oxidase-like-2-hloxl2-in-a-precursor-state
#3
Xi Zhang, Qifan Wang, Jianping Wu, Jiawei Wang, Yigong Shi, Minhao Liu
Lysyl oxidases (LOXs), a type of copper- and lysyl tyrosylquinone (LTQ) -dependent amine oxidase, catalyze the oxidative deamination of lysine residues of extracellular matrix (ECM) proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for ECM modeling. Despite their physiological significance, the structure of this important family of enzymes remains elusive...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29576712/computational-tool-for-immunotoxic-assessment-of-pyrethroids-toward-adaptive-immune-cell-receptors
#4
Anoop Kumar, Padma Charan Behera, Naresh Kumar Rangra, Suddhasattya Dey, Kamal Kant
Background: Pyrethroids have prominently known for their insecticidal actions worldwide, but recent reports as anticancer and antiviral applications gained a lot of interest to further understand their safety and immunotoxicity. Objective: This encouraged us to carry out our present study to evaluate the interactions of pyrethroids toward adaptive immune cell receptors. Materials and Methods: Type 1 and Type 2 pyrethroids were tested on T (CD4 and CD8) and B (CD28 and CD45) immune cell receptors using Maestro 9...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29571464/the-roles-of-bacteria-in-the-biochemical-changes-of-chill-stored-bighead-carp-aristichthys-nobilis-proteins-degradation-biogenic-amines-accumulation-volatiles-production-and-nucleotides-catabolism
#5
Xiaochang Liu, Zhan Huang, Shiliang Jia, Jingbin Zhang, Kaifeng Li, Yongkang Luo
This study investigated the biochemical changes (proteins degradation, total volatile basic nitrogen, biogenic amines, volatile organic compounds, nucleotides catabolism and related enzymes) of bighead carp samples inoculated with four different bacteria (Shewanella putrefaciens, Aeromonas sobria, Acinetobacter bohemicus, and Pseudomonas helmanticensis) during storage at 4 ± 1 °C. A. sobria exhibited the strongest proteolytic activity. A. sobria, P. helmanticensis, and S. putrefaciens were responsible for putrescine production, whereas S...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29569037/monoamine-oxidase-b-inhibitors-in-the-treatment-of-parkinson-s-disease-clinical-pharmacological-aspects
#6
REVIEW
Peter Riederer, Thomas Müller
This invited narrative review emphasizes the role of MAO-B inhibition in the drug portfolio for dopamine substitution in patients with Parkinson's disease. Neuronal and glial MAO-B inhibition contributes to more stable levels of dopamine and other biogenic amines in the synaptic cleft. Accordingly, symptomatic effects of MAO-B inhibition for a limited amelioration of impaired motor behaviour and wearing-off phenomena in patients with Parkinson's disease are well proven, even when MAO-B inhibitors are only applied together with dopamine agonists...
March 22, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29568754/monoamine-oxidase-a-inhibition-and-associated-antioxidant-activity-in-plant-extracts-with-potential-antidepressant-actions
#7
Tomás Herraiz, Hugo Guillén
Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum , Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the antioxidant activity associated with the inhibition of MAO is determined in plant extracts for the first time. H. perforatum inhibited human MAO-A, and extracts from flowers gave the highest inhibition (IC50 of 63...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29551589/impairing-l-threonine-catabolism-promotes-healthspan-through-methylglyoxal-mediated-proteohormesis
#8
Meenakshi Ravichandran, Steffen Priebe, Giovanna Grigolon, Leonid Rozanov, Marco Groth, Beate Laube, Reinhard Guthke, Matthias Platzer, Kim Zarse, Michael Ristow
Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC 2.3.1.29). Impairing gcat expression promotes the lifespan of C. elegans by interfering with threonine catabolism to promote methylglyoxal (MGO; CAS 78-98-8) formation in an amine oxidase-dependent manner. MGO is a reactive dicarbonyl inducing diabetic complications in mammals by causing oxidative stress and damaging cellular components, including proteins...
March 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29550344/hplc-uv-assays-for-evaluation-of-inhibitors-of-mono-and-diamine-oxidases-using-novel-phenyltetrazolylalkanamine-substrates
#9
Kira Mergemeier, Matthias Lehr
Recently, we have described an HPLC-UV assay for the evaluation of inhibitors of plasma amine oxidase (PAO) using 6-(5-phenyl-2H-tetrazol-2-yl)hexan-1-amine (4) as a new type of substrate. Now we studied, whether this compound or homologues of it can also function as substrate for related amine oxidases, namely diamine oxidase (DAO), monoamine oxidase A (MAO A) and monoamine oxidase B (MAO B). Among these substances, 4 was converted by DAO with the highest rate. The best substrate for MAO A and B was 4-(5-phenyl-2H-tetrazol-2-yl)butan-1-amine (2)...
March 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29541533/impulse-control-disorders-in-parkinson-s-sleep-disorders-and-nondopaminergic-associations
#10
Samuel Carbunaru, Robert S Eisinger, Adolfo Ramirez-Zamora, Dana Bassan, Amin Cervantes-Arriaga, Mayela Rodriguez-Violante, Daniel Martinez-Ramirez
Objectives: Impulse control disorders (ICDs) are common among patients with Parkinson's disease (PD). Risk factors identified for developing ICDs include young age, family history, and impulsive personality traits. However, the association of these potentially disabling disorders with nondopaminergic drugs and sleep disorders has been understudied. Our objective was to examine the association between ICDs and nondopaminergic medications and sleep disorders. Methods: We conducted an observational study of 53 patients with PD from the National Institute of Neurology and Neurosurgery...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29516165/kinetics-mechanism-and-inhibition-of-monoamine-oxidase
#11
REVIEW
Rona R Ramsay, Alen Albreht
Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs. While inhibition of MAO activity in the periphery removes protection from biogenic amines and so is undesirable, inhibition in the brain gives vital antidepressant and behavioural advantages that make MAO a major pharmaceutical target for inhibitor design. In neurodegenerative diseases, MAO inhibitors can help to maintain neurotransmitter levels, making it a common feature in novel multi-target combinations designed to combat Alzheimer's disease, albeit not yet proven clinically...
March 7, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29498828/protein-derived-cofactors-revisited-empowering-amino-acid-residues-with-new-functions
#12
Victor L Davidson
A protein-derived cofactor is a catalytic or redox-active site in a protein that is formed by post-translational modification of one or more amino acid residues. These post-translational modifications are irreversible and endow the modified amino acid residues with new functional properties. This Perspective focusses on the following advances in this area that have occurred during recent years. The biosynthesis of the tryptophan tryptophylquinone (TTQ) cofactor is catalyzed by a di-heme enzyme, MauG. A bis-FeIV redox state of the hemes performs three two-electron oxidations of specific Trp residues via long-range electron transfer...
March 2, 2018: Biochemistry
https://www.readbyqxmd.com/read/29483632/the-chejuenolide-biosynthetic-gene-cluster-harboring-an-iterative-trans-at-pks-system-in-hahella-chejuensis-strain-mb-1084
#13
Bee Gek Ng, Jae Woo Han, Dong Wan Lee, Gyung Ja Choi, Beom Seok Kim
Hahella chejuensis MB-1084 is a Gram-negative marine bacterial strain that produces unusual 17-membered carbocyclic tetraenes, chejuenolide A and B. Two fosmid clones responsible for chejuenolide production were identified from the genomic DNA library of the MB-1084 strain. Systematic inactivation of the open reading frames (ORFs) in the sequenced region defines the boundaries of the chejuenolide (che) biosynthetic gene cluster (24.9 kbp) that encodes one non-ribosomal peptide synthase (NRPS)-polyketide synthase (PKS) hybrid protein, three modular PKSs, two PKS domains, and an amine oxidase homolog...
February 26, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29477859/bioamination-of-alkane-with-ammonium-by-an-artificially-designed-multienzyme-cascade
#14
Hui-Lei Yu, Tuo Li, Fei-Fei Chen, Xiao-Jing Luo, Aitao Li, Chao Yang, Gao-Wei Zheng, Jian-He Xu
Biocatalytic C-H amination is one of the most challenging tasks. C-H amination reaction can hardly be driven efficiently by solely one enzyme so far. Thus, enzymatic synergy represents an alternative strategy. Herein, we report an "Artificially Bioamination Pathway" for C-H amination of cyclohexane as a model substrate. Three enzymes, a monooxygenase P450BM3 mutant, an alcohol dehydrogenase ScCR from Streptomyces coelicolor and an amine dehydrogenase EsLeuDH from Exiguobactertium sibiricum, constituted a clean cascade reaction system with easy product isolation...
February 22, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29475774/diamine-oxidase-dao-supplement-reduces-headache-in-episodic-migraine-patients-with-dao-deficiency-a-randomized-double-blind-trial
#15
Joan Izquierdo-Casas, Oriol Comas-Basté, M Luz Latorre-Moratalla, Marian Lorente-Gascón, Adriana Duelo, Luis Soler-Singla, M Carmen Vidal-Carou
BACKGROUND & AIMS: Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among histamine related symptoms, headache is one of the most recorded. Current clinical strategies for the treatment of the symptomatology related to this disorder are based on the exclusion of foods with histamine or other bioactive amines and/or exogenous DAO supplementation...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29471242/development-of-a-glucose-sensor-employing-quick-and-easy-modification-method-with-mediator-for-altering-electron-acceptor-preference
#16
Mika Hatada, Noya Loew, Yuka Inose-Takahashi, Junko Okuda-Shimazaki, Wakako Tsugawa, Ashok Mulchandani, Koji Sode
Enzyme based electrochemical biosensors are divided into three generations according to their type of electron transfer from the cofactors of the enzymes to the electrodes. Although the 3rd generation sensors using direct electron transfer (DET) type enzymes are ideal, the number of enzyme types which possess DET ability is limited. In this study, we report of a glucose sensor using mediator-modified glucose dehydrogenase (GDH), that was fabricated by a new quick-and-easy method using the pre-functionalized amine reactive phenazine ethosulfate (arPES)...
February 9, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29438782/analgesic-effects-of-the-novel-semicarbazide-sensitive-amine-oxidase-inhibitor-szv-1287-in-mouse-pain-models-with-neuropathic-mechanisms-involvement-of-transient-receptor-potential-vanilloid-1-and-ankyrin-1-receptors
#17
Ádám Horváth, Valéria Tékus, Noémi Bencze, Nikolett Szentes, Bálint Scheich, Kata Bölcskei, Éva Szőke, Attila Mócsai, Éva Tóth-Sarudy, Péter Mátyus, Erika Pintér, Zsuzsanna Helyes
Semicarbazide-sensitive amine oxidase (SSAO) produces tissue irritants by deamination of primary amines, which activate transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors expressed predominantly on nociceptors. Since there are no data about its functions in pain, we studied the effects and mechanisms of action of our novel SSAO inhibitor and dual TRPA1/TRPV1 antagonist multi-target drug SZV 1287 in different pain models. Acute chemonociception was induced by TRPV1 and TRPA1 activation (resiniferatoxin and formalin, respectively), chronic arthritis by K/BxN serum transfer, traumatic mononeuropathy by sciatic nerve ligation...
February 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29425238/host-parasite-co-metabolic-activation-of-antitrypanosomal-aminomethyl-benzoxaboroles
#18
Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restricted by a lack of insight into mechanism of action (MoA) in pathogenic kinetoplastids. We adopted a multidisciplinary approach, combining a high-throughput forward genetic screen with functional group focused chemical biological, structural biology and biochemical analyses, to tackle the complex MoAs of benzoxaboroles in Trypanosoma brucei...
February 9, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29408313/tmt-based-quantitative-proteomics-analysis-reveals-the-response-of-camellia-sinensis-to-fluoride
#19
Yanli Liu, Dan Cao, Linlong Ma, Xiaofang Jin, Pingfang Yang, Fei Ye, Panpan Liu, Ziming Gong, Chaoling Wei
The tea plant is a fluoride hyperaccumulator, and fluoride accumulation in its leaves is closely related to human health. To dissect molecular mechanisms underlying fluoride accumulation/detoxification, the leaves of tea seedlings exposed to different fluoride treatments for 30 days were sampled for physiological and proteomics analyses. The results showed that fluoride had no adverse effects on the growth of tea seedlings in spite of high content fluoride accumulation in their leaves. Through TMT coupled with UPLC MS/MS, 189 differentially accumulated proteins were quantified, of which 41 and 148 were localized in the cell wall and cellular compartments respectively...
February 2, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29400049/ratiometric-near-infrared-fluorescent-probe-for-synergistic-detection-of-monoamine-oxidase-b-and-its-contribution-to-oxidative-stress-in-cell-and-mice-aging-models
#20
Rui Wang, Xiaoyue Han, Jin-Mao You, Fabiao Yu, Lingxin Chen
As new biomarkers, monoamine oxidases (MAOs) play important roles in maintaining the homeostasis of biogenic amines via catalyzing the oxidation of biogenic amines to corresponding aldehydes with the generation of reactive oxygen species (ROS). MAOs have two isoforms, MAO-A and MAO-B. MAO-A is considered to be a major factor of neuropsychiatric and depressive disorders. However, MAO-B is thought to be involved in several neurodegenerative diseases. Therefore, to explore their distinct roles in different diseases, the selective detection of MAOs is essential...
February 5, 2018: Analytical Chemistry
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