keyword
MENU ▼
Read by QxMD icon Read
search

omega braun

keyword
https://www.readbyqxmd.com/read/24504445/a-randomized-phase-iii-study-comparing-pegylated-liposomal-doxorubicin-with-capecitabine-as-first-line-chemotherapy-in-elderly-patients-with-metastatic-breast-cancer-results-of-the-omega-study-of-the-dutch-breast-cancer-research-group-boog
#1
RANDOMIZED CONTROLLED TRIAL
C H Smorenburg, S M de Groot, A E van Leeuwen-Stok, M E Hamaker, A N Wymenga, H de Graaf, F E de Jongh, J J Braun, M Los, E Maartense, H van Tinteren, J W R Nortier, C Seynaeve
BACKGROUND: Prospective data on chemotherapy for elderly patients with metastatic breast cancer (MBC) remain scarce. We compared the efficacy and safety of first-line chemotherapy with pegylated liposomal doxorubicin (PLD) versus capecitabine in MBC patients aged ≥65 years in a multicentre, phase III trial. PATIENTS AND METHODS: Patients were randomized to six cycles of PLD (45 mg/m(2) every 4 weeks) or eight cycles of capecitabine (1000 mg/m(2) twice daily, day 1-14 every 3 weeks)...
March 2014: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/24314824/baseline-comprehensive-geriatric-assessment-is-associated-with-toxicity-and-survival-in-elderly-metastatic-breast-cancer-patients-receiving-single-agent-chemotherapy-results-from-the-omega-study-of-the-dutch-breast-cancer-trialists-group
#2
RANDOMIZED CONTROLLED TRIAL
M E Hamaker, C Seynaeve, A N M Wymenga, H van Tinteren, J W R Nortier, E Maartense, H de Graaf, F E de Jongh, J J Braun, M Los, J G Schrama, A E van Leeuwen-Stok, S M de Groot, C H Smorenburg
AIM: To evaluate the association between baseline comprehensive geriatric assessment (CGA) or the Groningen Frailty Indicator (GFI) and toxicity in elderly metastatic breast cancer (MBC) patients treated with first-line palliative chemotherapy. PATIENTS AND METHODS: MBC patients (≥65 years) were randomized between pegylated liposomal doxorubicine or capecitabine. CGA included instrumental activities of daily living (IADL), cognition using the mini-mental state examination (MMSE), mood using the geriatric depression scale (GDS), comorbidity using the Charlson index, polypharmacy and nutritional status using the body mass index...
February 2014: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/23423329/restoration-of-mannose-binding-lectin-complement-activity-is-associated-with-improved-outcome-in-patients-with-advanced-pancreatic-cancer-treated-with-gemcitabine-and-intravenous-%C3%AF-3-fish-oil
#3
Ali Arshad, Wen Chung, John Isherwood, William Steward, Matthew Metcalfe, Ashley Dennison
BACKGROUND: Pancreatic cancer has an extremely poor clinical outcome. Surrogate biomarkers for outcome are scarce. There is mixed evidence for the association of high mannose-binding lectin (MBL) complement activity with cancer outcomes, including reduced survival and increased infectious complications. ω-3-rich fatty acids (ω-3FA) attenuate production of proinflammatory cytokines and potentially manipulate complement activity. MATERIALS AND METHODS: As part of a single-arm phase II trial in a university hospital, patients with advanced pancreatic adenocarcinoma were treated with weekly ω-3FA-rich intravenous infusion (Lipidem [B...
February 2014: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/21477318/effects-of-an-omega-3-fatty-acid-enriched-lipid-emulsion-on-eicosanoid-synthesis-in-acute-respiratory-distress-syndrome-ards-a-prospective-randomized-double-blind-parallel-group-study
#4
Joan Sabater, Joan Ramon Masclans, Judit Sacanell, Pilar Chacon, Pilar Sabin, Mercè Planas
BACKGROUND: The use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. The type and quantity of the lipid emulsions used could modulate this response, which is mediated by the eicosanoids. This study investigates the use of omega-3 fatty acid-enriched lipid emulsions in ARDS patients and their effects on eicosanoid values. METHODS: Prospective, randomized, double-blind, parallel group study carried out at the Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain)...
2011: Nutrition & Metabolism
https://www.readbyqxmd.com/read/21364873/maternal-high-fat-diet-is-associated-with-decreased-plasma-n-3-fatty-acids-and-fetal-hepatic-apoptosis-in-nonhuman-primates
#5
Wilmon F Grant, Melanie B Gillingham, Ayesha K Batra, Natasha M Fewkes, Sarah M Comstock, Diana Takahashi, Theodore P Braun, Kevin L Grove, Jacob E Friedman, Daniel L Marks
To begin to understand the contributions of maternal obesity and over-nutrition to human development and the early origins of obesity, we utilized a non-human primate model to investigate the effects of maternal high-fat feeding and obesity on breast milk, maternal and fetal plasma fatty acid composition and fetal hepatic development. While the high-fat diet (HFD) contained equivalent levels of n-3 fatty acids (FA's) and higher levels of n-6 FA's than the control diet (CTR), we found significant decreases in docosahexaenoic acid (DHA) and total n-3 FA's in HFD maternal and fetal plasma...
2011: PloS One
https://www.readbyqxmd.com/read/21301768/laparoscopic-duodenojejunostomy-omega-loop-with-braun-anastomosis-as-a-treatment-for-superior-mesenteric-artery-syndrome
#6
Baraa K Alnabulsi, Jameel T Miro, Osama H Faidah, Mahmoud A Hamo
Superior mesenteric artery (SMA) syndrome is a rare clinical phenomenon caused by compression of the third portion of the duodenum by the overlying SMA, and can be easily misdiagnosed. We report a case of SMA syndrome treated with laparoscopic duodenojejunostomy omega loop with Braun anastomosis. A 24-year-old women with body mass index of 14.9 presented with a 4-year history of vague abdominal pain mainly at the epigastric region, radiating to the back associated with heartburn, repeated vomiting, and significant loss of weight during the previous 6 months...
February 2011: Saudi Medical Journal
https://www.readbyqxmd.com/read/21034003/streaked-radiography-measurements-of-convergent-ablator-performance-invited
#7
D G Hicks, B K Spears, D G Braun, R E Olson, C M Sorce, P M Celliers, G W Collins, O L Landen
The velocity and remaining ablator mass of an imploding capsule are critical metrics for assessing the progress toward ignition of an inertially confined fusion experiment. These and other ablator rocket parameters have been measured using a single streaked x-ray radiograph. A regularization technique has been used to determine the ablator density profile ρ(r) at each time step; moments of ρ(r) then provide the areal density, average radius, and mass of the unablated, or remaining, ablator material, with the velocity determined from the time derivative of the average radius...
October 2010: Review of Scientific Instruments
https://www.readbyqxmd.com/read/20547976/membrane-potential-dependent-inactivation-of-voltage-gated-ion-channels-in-alpha-cells-inhibits-glucagon-secretion-from-human-islets
#8
Reshma Ramracheya, Caroline Ward, Makoto Shigeto, Jonathan N Walker, Stefan Amisten, Quan Zhang, Paul R Johnson, Patrik Rorsman, Matthias Braun
OBJECTIVE: To document the properties of the voltage-gated ion channels in human pancreatic alpha-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS: Glucagon release was measured from intact islets. [Ca(2+)](i) was recorded in cells showing spontaneous activity at 1 mmol/l glucose. Membrane currents and potential were measured by whole-cell patch-clamping in isolated alpha-cells identified by immunocytochemistry. RESULT: Glucose inhibited glucagon secretion from human islets; maximal inhibition was observed at 6 mmol/l glucose...
September 2010: Diabetes
https://www.readbyqxmd.com/read/19590750/synthesis-of-novel-photochromic-pyrans-via-palladium-mediated-reactions
#9
Christoph Böttcher, Gehad Zeyat, Saleh A Ahmed, Elisabeth Irran, Thorben Cordes, Cord Elsner, Wolfgang Zinth, Karola Rueck-Braun
Photochromic pyrans for applications in material and life sciences were synthesized via palladium-mediated cyanation, carbonylation and Sonogashira cross-coupling starting from bromo-substituted naphthopyran 1 and benzopyrans 2a/b. A novel photoswitchable benzopyran-based omega-amino acid 6 for Fmoc-based solid-phase peptide synthesis is presented. The photochromic behaviour of the 3-cyano-substituted benzopyran 5a was investigated by time-resolved absorption spectroscopy in the picosecond time domain.
2009: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/19440689/somatostatin-release-electrical-activity-membrane-currents-and-exocytosis-in-human-pancreatic-delta-cells
#10
M Braun, R Ramracheya, S Amisten, M Bengtsson, Y Moritoh, Q Zhang, P R Johnson, P Rorsman
AIMS/HYPOTHESIS: The aim of this study was to characterise electrical activity, ion channels, exocytosis and somatostatin release in human delta cells/pancreatic islets. METHODS: Glucose-stimulated somatostatin release was measured from intact human islets. Membrane potential, currents and changes in membrane capacitance (reflecting exocytosis) were recorded from individual human delta cells identified by immunocytochemistry. RESULTS: Somatostatin secretion from human islets was stimulated by glucose and tolbutamide and inhibited by diazoxide...
August 2009: Diabetologia
https://www.readbyqxmd.com/read/18947396/effects-on-hemodynamics-and-gas-exchange-of-omega-3-fatty-acid-enriched-lipid-emulsion-in-acute-respiratory-distress-syndrome-ards-a-prospective-randomized-double-blind-parallel-group-study
#11
RANDOMIZED CONTROLLED TRIAL
Joan Sabater, Joan Ramon Masclans, Judit Sacanell, Pilar Chacon, Pilar Sabin, Merce Planas
INTRODUCTION: We investigated the effects on hemodynamics and gas exchange of a lipid emulsion enriched with omega-3 fatty acids in patients with ARDS. METHODS: The design was a prospective, randomized, double-blind, parallel group study in our Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain). We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men and 2 women; mean age: 58 +/- 13 years; APACHE II score: 17...
2008: Lipids in Health and Disease
https://www.readbyqxmd.com/read/18700010/duplications-and-functional-divergence-of-adp-glucose-pyrophosphorylase-genes-in-plants
#12
Nikolaos Georgelis, Edward L Braun, L Curtis Hannah
BACKGROUND: ADP-glucose pyrophosphorylase (AGPase), which catalyses a rate limiting step in starch synthesis, is a heterotetramer comprised of two identical large and two identical small subunits in plants. Although the large and small subunits are equally sensitive to activity-altering amino acid changes when expressed in a bacterial system, the overall rate of non-synonymous evolution is approximately 2.7-fold greater for the large subunit than for the small subunit. Herein, we examine the basis for their different rates of evolution, the number of duplications in both large and small subunit genes and document changes in the patterns of AGPase evolution over time...
2008: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/18390794/voltage-gated-ion-channels-in-human-pancreatic-beta-cells-electrophysiological-characterization-and-role-in-insulin-secretion
#13
Matthias Braun, Reshma Ramracheya, Martin Bengtsson, Quan Zhang, Jovita Karanauskaite, Chris Partridge, Paul R Johnson, Patrik Rorsman
OBJECTIVE: To characterize the voltage-gated ion channels in human beta-cells from nondiabetic donors and their role in glucose-stimulated insulin release. RESEARCH DESIGN AND METHODS: Insulin release was measured from intact islets. Whole-cell patch-clamp experiments and measurements of cell capacitance were performed on isolated beta-cells. The ion channel complement was determined by quantitative PCR. RESULTS: Human beta-cells express two types of voltage-gated K(+) currents that flow through delayed rectifying (K(V)2...
June 2008: Diabetes
https://www.readbyqxmd.com/read/18367584/estrogen-and-the-ca2-mobilizing-agonist-atp-evoke-acute-no-synthesis-via-distinct-pathways-in-an-individual-human-vascular-endothelium-derived-cell
#14
Jian-Zhong Sheng, Furqan Arshad, Janice E Braun, Andrew P Braun
In this study, we have systematically evaluated the signaling mechanisms underlying stimulated nitric oxide (NO) synthesis by estrogen (E2) and other vasoactive agents at the level of a single endothelium-derived cell. To do so, we have characterized and contrasted rapid E2-evoked NO synthesis with that of ATP using single-cell microfluorimetry and patch-clamp recordings to monitor stimulated changes in cellular NO synthesis (via 4-amino-5-methylamino-2',7'-difluorofluorescein), Ca2+ transients (via Fluo-3), and membrane hyperpolarization in cultured human EA...
June 2008: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/17614347/photochemical-z-e-isomerization-of-a-hemithioindigo-hemistilbene-omega-amino-acid
#15
Thorben Cordes, Björn Heinz, Nadja Regner, Christian Hoppmann, Tobias E Schrader, Wolfram Summerer, Karola Rück-Braun, Wolfgang Zinth
The molecule HTI, which combines hemithioindigo and hemistilbene molecular parts, allows reversible switching between two isomeric states. Photochromic behaviour of the HTI molecule is observed by irradiation with UV/Vis light. The photochemical reaction, a Z/E isomerization around the central double bond connecting the two molecular parts, is investigated by transient absorption and emission spectroscopy. For a special HTI molecule, namely, an omega-amino acid, the Z-->E isomerization process occurs on a timescale of 30 ps...
August 6, 2007: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/17358850/dielectron-production-in-12c-12c-collisions-at-2a-gev-with-the-hades-spectrometer
#16
G Agakichiev, C Agodi, H Alvarez-Pol, A Bałanda, D Bertini, J Bielcik, G Bellia, M Böhmer, H Bokemeyer, J L Boyard, P Braun-Munzinger, P Cabanelas, S Chernenko, T Christ, R Coniglione, L Cosentino, J Díaz, F Dohrmann, I Durán, T Eberl, W Enghardt, L Fabbietti, O Fateev, C Fernandez, P Finocchiaro, J Friese, I Fröhlich, B Fuentes, C Garabatos, J A Garzón, R Gernhäuser, C Gilardi, M Golubeva, D González-Díaz, E Grosse, F Guber, T Hennino, S Hlavac, R Holzmann, J Homolka, A Ierusalimov, I Iori, A Ivashkin, M Jaskuła, M Jurkovic, M Kagarlis, M Kajetanowicz, B Kämpfer, K Kanaki, T Karavicheva, A Kastenmüller, L Kidoń, P Kienle, I Koenig, W Koenig, H J Körner, B W Kolb, R Kotte, R Krücken, A Kugler, W Kühn, R Kulessa, A Kurepin, S Lang, S Lange, J Lehnert, E Lins, D Magestro, C Maiolino, A Malarz, J Markert, V Metag, J Mousa, M Münch, C Müntz, L Naumann, A Nekhaev, J Novotny, J Otwinowski, Y C Pachmayer, V Pechenov, T Pérez, P Piattelli, J Pietraszko, R Pleskac, M Płoskoń, V Pospísil, W Prokopowicz, W Przygoda, B Ramstein, A Reshetin, J Ritman, M Roy-Stephan, A Rustamov, A Sadovsky, B Sailer, P Salabura, M Sánchez, P Sapienza, A Schmah, H Schön, W Schön, C Schröder, E Schwab, R S Simon, V Smolyankin, L Smykov, S Spataro, B Spruck, H Ströbele, J Stroth, C Sturm, M Sudoł, M Suk, A Taranenko, P Tlusty, A Toia, M Traxler, H Tsertos, D Vassiliev, A Vázquez, V Wagner, W Waluś, M Wiśniowski, T Wójcik, J Wüstenfeld, Y Zanevsky, K Zeitelhack, D Zovinec, P Zumbruch et al.
The invariant-mass spectrum of e+e- pairs produced in 12C+12C collisions at an incident energy of 2 GeV per nucleon has been measured for the first time. The measured pair production probabilities span over 5 orders of magnitude from the pi(0)-Dalitz to the rho/omega invariant-mass region. Dalitz decays of pi(0) and eta account for all the yield up to 0.15 GeV/c(2), but for only about 50% above this mass. A comparison with model calculations shows that the excess pair yield is likely due to baryon-resonance and vector-meson decays...
February 2, 2007: Physical Review Letters
https://www.readbyqxmd.com/read/17318052/laparoscopic-conversion-of-an-omega-in-a-roux-en-y-reconstruction-after-mini-invasive-total-gastrectomy-for-cancer-a-technical-report
#17
Gianluca Rossetti, Gianmattia del Genio, Vincenzo Maffettone, Vincenzo Napolitano, Luigi Brusciano, Gianluca Russo, Paolo Limongelli, Irene Fiume, Francesco Pizza, Alberto del Genio
INTRODUCTION: Few cases of laparoscopic total gastrectomy have been published. Reconstruction of the digestive tract was generally accomplished with a Roux-en-y esophagojejunal mechanical anastomosis. Here we report the first 2 cases of laparoscopic conversion of an omega in a Roux-en-y reconstruction due to the occurrence of a severe alkaline esophagitis after mini-invasive total gastrectomy for cancer. MATERIALS AND METHODS: Two male patients presented in 2004...
February 2007: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/17267422/the-evolution-of-seminal-ribonuclease-pseudogene-reactivation-or-multiple-gene-inactivation-events
#18
Slim O Sassi, Edward L Braun, Steven A Benner
Two approaches, one novel, are applied to analyze the divergent evolution of ruminant seminal ribonucleases (RNases), paralogs of the well-known pancreatic RNases of mammals. Here, the goal was to identify periods of divergence of seminal RNase under functional constraints, periods of divergence as a pseudogene, and periods of divergence driven by positive selection pressures. The classical approach involves the analysis of nonsynonymous to synonymous replacements ratios (omega) for the branches of the seminal RNase evolutionary tree...
April 2007: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/17202435/supplementation-of-omega-3-fatty-acids-in-parenteral-nutrition-beneficially-alters-phospholipid-fatty-acid-pattern
#19
RANDOMIZED CONTROLLED TRIAL
Metin Senkal, Bruno Geier, Martin Hannemann, Thomas Deska, Jakob Linseisen, Günther Wolfram, Michael Adolph
BACKGROUND: The clinical safety and the uptake of omega-3 polyunsaturated fatty acids (PUFA) into the serum phospholipids and erythrocyte membranes after administration of fish-oil-supplemented parenteral nutrition (PN) was investigated in colorectal surgical patients. METHODS: Forty patients undergoing colorectal surgery (n = 40) and with an indication for PN were enrolled in a prospective, double-blind, randomized study to receive an omega-3 PUFA-supplemented 20% lipid emulsion (Lipoplus; B...
January 2007: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/16698551/structure-of-the-mammalian-nos-regulator-dimethylarginine-dimethylaminohydrolase-a-basis-for-the-design-of-specific-inhibitors
#20
Daniel Frey, Oliver Braun, Christophe Briand, Milan Vasák, Markus G Grütter
Dimethylarginine dimethylaminohydrolase (DDAH) is involved in the regulation of nitric oxide synthase (NOS) by metabolizing the free endogenous arginine derivatives N(omega)-methyl-L-arginine (MMA) and N(omega),N(omega)-dimethyl-L-arginine (ADMA), which are competitive inhibitors of NOS. Here, we present high-resolution crystal structures of DDAH isoform 1 (DDAH-1) isolated from bovine brain in complex with different inhibitors, including S-nitroso-L-homocysteine and Zn2+, a regulator of this mammalian enzyme...
May 2006: Structure
keyword
keyword
88192
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"