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lactate clearance

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https://www.readbyqxmd.com/read/29909577/population-pharmacokinetic-model-for-tumescent-lidocaine-in-women-undergoing-breast-cancer-surgery
#1
Camille Riff, Aurélie Bourgoin, Amelie Marsot, Laurent Allanioux, Marc Leone, Olivier Blin, Romain Guilhaumou
PURPOSE: Tumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocaine in a context of TLA during a unilateral mastectomy. The aim of this study was to describe lidocaine pharmacokinetics in elderly women undergoing breast cancer surgery after TLA and to explore the risk of the toxicity of this technique. METHODS: A prospective study was conducted to examine the pharmacokinetics of lidocaine in women undergoing TLA...
June 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29898629/a-retrospective-review-of-on-admission-factors-on-attainment-of-therapeutic-serum-concentrations-of-magnesium-sulfate-in-women-treated-for-a-diagnosis-of-preeclampsia
#2
Jarunee Leetheeragul, Dittakarn Boriboonhirunsarn, Kanit Reesukumal, Nusara Srisaimanee, Siriluck Horrasith, Tuangsit Wataganara
INTRODUCTION: There is little information on the effect of maternal characteristics and on-admission laboratory parameters to the therapeutic serum magnesium sulfate (MgSO4) levels in women with preeclampsia (PE). We sought to identify factors that may predict timely attainment of therapeutic serum magnesium levels after intravenous administration for seizure prophylaxis. MATERIALS AND METHODS: On-admission factors of 360 women with PE who received intravenous MgSO4 (4-g loading and 2-g/hr maintenance) for seizure prophylaxis were retrospectively reviewed...
June 13, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29881625/the-lactate-clearance-calculated-using-serum-lactate-level-6-h-after-is-an-important-prognostic-predictor-after-extracorporeal-cardiopulmonary-resuscitation-a-single-center-retrospective-observational-study
#3
Takashi Mizutani, Norio Umemoto, Toshio Taniguchi, Hideki Ishii, Yuri Hiramatsu, Koji Arata, Horagaito Takuya, Sho Inoue, Tsuyoshi Sugiura, Toru Asai, Michiharu Yamada, Toyoaki Murohara, Kiyokazu Shimizu
Background: Serum lactate level can predict clinical outcomes in some critical cases. In the clinical setting, we noted that patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) and with poor serum lactate improvement often do not recover from cardiopulmonary arrest. Therefore, we investigated the association between lactate clearance and in-hospital mortality in cardiac arrest patients undergoing ECPR. Methods: Serum lactate levels were measured on admission and every hour after starting ECPR...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29846099/insulin-metabolism-and-assessment-of-hepatic-insulin-extraction-during-liver-regeneration-a-study-in-a-rat-model
#4
Thomas Kotsis, Constantinos Nastos, Konstantinos Stamatis, Ioanna Chondroudaki, Agathi Pafiti, Mata Frangou, Vina Kotsovolou, Konstantinos Chondros, Vasileios Smirniotis, Alexios Fotopoulos
BACKGROUND: Liver regeneration is a complex procedure in which insulin metabolism has been implicated. The aim of this experimental study was to evaluate the role of insulin in rat hepatic regeneration following major hepatectomy (70%), employing an isolated perfused rat liver (IPRL) model to assess the extraction of insulin from the regenerating liver. METHODS: Eighty-six male rats were randomized in 9 groups. A group of rats was studied at postoperative day (POD) 1 having a sham operation while control rats had no operation...
May 30, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29770219/determinants-and-prognosis-of-high-sensitivity-cardiac-troponin-t-peak-plasma-concentration-in-patients-hospitalized-for-non-cardiogenic-shock
#5
Marie Caujolle, Jerome Allyn, Caroline Brulliard, Dorothée Valance, David Vandroux, Olivier Martinet, Nicolas Allou
Purpose: The aim of this study was to assess the determinants and prognostic value of high-sensitivity cardiac troponin T peak plasma concentration in intensive care unit patients with non-cardiogenic shock. Material and methods: A prospective observational cohort study was conducted in a single intensive care unit between November 2014 and December 2015. Results: During the study period, 206 patients were hospitalized in the intensive care unit for non-cardiogenic shock and the median peak high-sensitivity cardiac troponin T was 55...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29761830/itc-commentary-on-metformin-clinical-drug-drug-interaction-study-design-that-enables-an-efficacy-and-safety-based-dose-adjustment-decision
#6
Maciej J Zamek-Gliszczynski, Xiaoyan Chu, Jack A Cook, Joseph M Custodio, Aleksandra Galetin, Kathleen M Giacomini, Caroline A Lee, Mary F Paine, Adrian S Ray, Joseph A Ware, Matthias B Wittwer, Lei Zhang
Metformin drug-drug interaction (DDI) studies are conducted during development of drugs that inhibit organic cation transporters and/or multidrug and toxin extrusion proteins (OCTs/MATEs). Monitoring solely changes in systemic exposure, the typical DDI study endpoint appears inadequate for metformin, which is metabolically stable, has poor passive membrane permeability, and undergoes transporter-mediated tissue distribution and clearance. Evaluation of renal clearance, antihyperglycemic effects, and potentially lactate as an exploratory safety marker, can support rational metformin dose adjustment...
May 15, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29754310/the-ten-pitfalls-of-lactate-clearance-in-sepsis
#7
Glenn Hernandez, Rinaldo Bellomo, Jan Bakker
No abstract text is available yet for this article.
May 12, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29747290/-the-relationship-between-arterial-blood-lactate-clearance-prognosis-and-myocardial-damage-in-patients-with-septic-shock-after-early-goal-directed-therapy
#8
X L Shang, D W Liu, X T Wang, H W He, H M Zhang, L X Su, P Pan
Objective: To evaluate the prognostic value of arterial blood lactate clearance based on central venous oxygen saturation and perfusion index in patients with septic shock related myocardial injury after early goal-directed therapy. Methods: One hundred and fifty-seven patients with septic shock after early resuscitation were enrolled from August 2013 to July 2016 in ICU at Peking Union Medical College Hospital. Parameters indicating early resuscitation included central venous pressure (CVP) 8-12 mmHg (1 mmHg=0...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29742750/a-systematic-review-on-the-effectiveness-of-active-recovery-interventions-on-athletic-performance-of-professional-collegiate-and-competitive-level-adult-athletes
#9
Robert O Ortiz, Amanda J Sinclair Elder, Craig L Elder, J Jay Dawes
OrtizJr, RO, Sinclair Elder, AJ, Elder, CL, and Dawes, JJ. A systematic review on the effectiveness of active recovery interventions on athletic performance of professional-, collegiate-, and competitive-level adult athletes. J Strength Cond Res XX(X): 000-000, 2018-Active recovery (AR) is a popular approach to enhancing athlete recovery from participation through physical action, and it has a perceived benefit in the recovery of athletes' enhancement of postexertional physiological status; however, it is unclear whether these recovery techniques enhance athletic performance...
May 8, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29733485/prednisone-pharmacokinetics-during-pregnancy-and-lactation
#10
Rachel J Ryu, Thomas R Easterling, Steve N Caritis, Raman Venkataramanan, Jason G Umans, Mahmoud S Ahmed, Shannon Clark, Ira Kantrowitz-Gordon, Karen Hays, Brooke Bennett, Matthew T Honaker, Kenneth E Thummel, Danny D Shen, Mary F Hebert
To evaluate the steady-state pharmacokinetics of prednisone and its metabolite prednisolone in pregnant and lactating female subjects, 19 subjects received prednisone (4-40 mg/day orally) in early (n = 3), mid (n = 9), and late (n = 13) pregnancy as well as postpartum with (n = 2) and without (n = 5) lactation. Serial blood and urine samples were collected over 1 dosing interval. Prednisone and its metabolite, prednisolone, steady-state noncompartmental pharmacokinetic parameters were estimated. During pregnancy, prednisone apparent oral clearance increased with dose (35...
May 7, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29722335/role-of-combining-peripheral-with-sublingual-perfusion-on-evaluating-microcirculation-and-predicting-prognosis-in-patients-with-septic-shock
#11
Pan Pan, Da-Wei Liu, Long-Xiang Su, Huai-Wu He, Xiao-Ting Wang, Chao Yu
Background: Measurement of general microcirculation remains difficult in septic shock patients. The peripheral perfusion index (PI) and sublingual microcirculation monitoring are thought to be possible methods. This study was performed to determine whether assessing microcirculation by PI and a new parameter, proportion of perfusion vessel change rate (△PPV) from sublingual microcirculation monitoring, can be associated with patients' outcome. Methods: A prospective observational study was carried out, including 74 patients with septic shock in a mixed intensive care unit...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29695623/tracking-polymicrobial-metabolism-in-cystic-fibrosis-airways-pseudomonas-aeruginosa-metabolism-and-physiology-are-influenced-by-rothia-mucilaginosa-derived-metabolites
#12
Bei Gao, Tara Gallagher, Ying Zhang, Mona Elbadawi-Sidhu, Zijuan Lai, Oliver Fiehn, Katrine L Whiteson
Due to a lack of effective immune clearance, the airways of cystic fibrosis patients are colonized by polymicrobial communities. One of the most widespread and destructive opportunistic pathogens is Pseudomonas aeruginosa ; however, P. aeruginosa does not colonize the airways alone. Microbes that are common in the oral cavity, such as Rothia mucilaginosa , are also present in cystic fibrosis patient sputum and have metabolic capacities different from those of P. aeruginosa Here we examine the metabolic interactions of P...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29690538/adipose-tissue-lactate-clearance-but-not-blood-lactate-clearance-is-associated-with-clinical-outcome-in-sepsis-or-septic-shock-during-the-post-resuscitation-period
#13
Ioannis Ilias, Sofia Apollonatou, Dimitra-Argyro Vassiliadi, Nikitas Nikitas, Maria Theodorakopoulou, Argyris Diamantakis, Anastasia Kotanidou, Ioanna Dimopoulou
No study has directly measured tissue lactate clearance in patients with sepsis during the post-resuscitation period. In this study we aimed to assess in ICU patients with sepsis ( n = 32) or septic shock ( n = 79)—during the post-resuscitation phase—the relative kinetics of blood/tissue lactate clearances and to examine whether these are associated with outcome. We measured serially—over a 48-h period—blood and adipose tissue interstitial fluid lactate levels (with microdialysis) and we calculated lactate clearance...
April 21, 2018: Metabolites
https://www.readbyqxmd.com/read/29686889/increases-in-heart-rate-variability-signal-improved-outcomes-in-rapid-response-team-consultations-a-cohort-study
#14
Nawal Salahuddin, Azam Shafquat, Qussay Marashly, Khaled Juan Zaza, Moh'd Sharshir, Moazzum Khurshid, Zeeshan Ali, Melissa Malgapo, Mouhamad Ghyath Jamil, Mohamed Shoukri, Mohammed Hijazi, Bandar Al-Ghamdi
Background: Reduced heart rate variability (HRV) indicates dominance of the sympathetic system and a state of "physiologic stress." We postulated that, in patients with critical illness, increases in HRV might signal successful resuscitation and improved prognosis. Methods: We carried out a prospective observational study of HRV on all patients referred to the rapid response team (RRT) and correlated with serial vital signs, lactate clearance, ICU admission, and mortality...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29625388/crocin-reverses-unilateral-renal-ischemia-reperfusion-injury-induced-augmentation-of-oxidative-stress-and-toll-like-receptor-4-activity
#15
Hadeer O Abou-Hany, Hoda Atef, Eman Said, Hassan A Elkashef, Hatem A Salem
Renal Ischemia (RI) usually develops as a secondary manifestation of hypertension, various cardiovascular disorders and renal transplantation. It exerts hypoxic oxidative stress to kidneys, together with stimulation of several immune-mediated inflammatory cascades. Such events eventually damage renal tubules and glomeruli, driving acute kidney injury (AKI) and ultimately, renal failure. Crocin; the main bioactive constituent of Crocus sativus extract has been reported to demonstrate numerous pharmacological merits...
April 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29618747/arteriovenous-blood-metabolomics-an-efficient-method-to-determine-the-key-metabolic-pathway-for-milk-synthesis-in-the-intra-mammary-gland
#16
Bing Wang, Huizeng Sun, Xuehui Wu, Linshu Jiang, Le Luo Guan, Jianxin Liu
The present study aimed to identify metabolic signature changes of the arteriovenous metabolome and the new metabolites that involved in mammary biological process during milk synthesis. GC/MS-based metabolomics profiling of arteriovenous plasma from 30 lactating dairy cows fed three diets identified a total of 144 metabolites. Phenylalanine and tyrosine, involved in aminoacyl-tRNA biosynthesis and phenylalanine metabolism, were shown higher expression in the artery than in the vein based on both GC/MS and targeted analysis for cows fed both alfalfa hay diet and rice straw diet...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608551/early-lactate-values-after-out-of-hospital-cardiac-arrest-associations-with-one-year-outcome
#17
Johanna Laurikkala, Markus B Skrifvars, Minna Bäcklund, Marjaana Tiainen, Stepani Bendel, Jaana Karhu, Tero Varpula, Jukka Vaahersalo, Ville Pettilä, Erika Wilkman
BACKGROUND: Previous studies have shown associations between high admission serum lactate, lower lactate clearance and increased short-term mortality after out-hospital cardiac arrest (OHCA). We studied whether lactate levels predict long- term outcome after OHCA. METHODS: We included 458 OHCA patients with lactate measurements during intensive care unit (ICU) stay from the prospective FINNRESUSCI study. We evaluated thresholds for time-weighted (TW) mean lactate values for the first 24, 48 and 72 hours...
March 30, 2018: Shock
https://www.readbyqxmd.com/read/29564205/from-gut-feeling-to-objectivity-machine-preservation-of-the-liver-as-a-tool-to-assess-organ-viability
#18
REVIEW
Christopher J E Watson, Ina Jochmans
Purpose of Review: The purpose of this review was to summarise how machine perfusion could contribute to viability assessment of donor livers. Recent Findings: In both hypothermic and normothermic machine perfusion, perfusate transaminase measurement has allowed pretransplant assessment of hepatocellular damage. Hypothermic perfusion permits transplantation of marginal grafts but as yet has not permitted formal viability assessment. Livers undergoing normothermic perfusion have been investigated using parameters similar to those used to evaluate the liver in vivo...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29557342/characterization-of-plasmodium-lactate-dehydrogenase-and-histidine-rich-protein-2-clearance-patterns-via-rapid-on-bead-detection-from-a-single-dried-blood-spot
#19
Christine F Markwalter, Lauren E Gibson, Lwiindi Mudenda, Danielle W Kimmel, Saidon Mbambara, Philip E Thuma, David W Wright
A rapid, on-bead enzyme-linked immunosorbent assay for Plasmodium lactate dehydrogenase ( p LDH) and Plasmodium falciparum histidine-rich protein 2 (HRP2) was adapted for use with dried blood spot (DBS) samples. This assay detected both biomarkers from a single DBS sample with only 45 minutes of total incubation time and detection limits of 600 ± 500 pM ( p LDH) and 69 ± 30 pM (HRP2), corresponding to 150 and 24 parasites/μL, respectively. This sensitive and reproducible on-bead detection method was used to quantify p LDH and HRP2 in patient DBS samples from rural Zambia collected at multiple time points after treatment...
May 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29546618/led-session-prior-incremental-step-test-enhance-vo-2max-in-running
#20
Paulo V Mezzaroba, Dalton M Pessôa Filho, Alessandro M Zagatto, Fabiana Andrade Machado
This study aimed to investigate the effect of prior LED sessions on the responses of cardiorespiratory parameters during the running incremental step test. Twenty-six healthy, physically active, young men, aged between 20 and 30 years, took part in this study. Participants performed two incremental load tests after placebo (PLA) and light-emitting diode application (LED), and had their gas exchange, heart rate (HR), blood lactate, and rating of perceived exertion (RPE) monitored during all tests. The PLA and LED conditions were compared using the dependent Student t test with significance set at 5%...
March 15, 2018: Lasers in Medical Science
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