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Xiao Liu, Yan Chen, Yaohua Zhang, Juan Du, Yubao Lv, Shuming Mo, Yingchao Liu, Feng Ding, Jinfeng Wu, Ji Li
Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL)‑based cancer therapy offers promise as TRAIL can kill cancer cells without apparent toxicity towards normal cells. However, intrinsic or acquired resistance to TRAIL inseveral types of cancer cell has become a major challenge in TRAIL‑based cancer therapy. Juglone is a natural compound isolated from walnut trees. In the present study, it was demonstrated that juglone sensitized melanoma cells to TRAIL‑induced cytotoxicity by MTT and crystal violet assays...
October 17, 2017: Molecular Medicine Reports
S Abou-El-Karam, J Ratel, N Kondjoyan, C Truan, E Engel
Starting with an experiment to authenticate walnut oils based on GC-MS analysis of the volatolome, this paper aims to demonstrate the relevance of a two-step alignment-based strategy for the systematic research of VOC markers. The first step of the treatment consists of roughly reducing the time shifts with efficient, known warping techniques like COW (Correlation Optimized Warping). The second step relies on an accurate peak apex alignment in order to refine residual local misalignments and to enable further systematic marker research through univariate or multivariate data treatments...
October 23, 2017: Analytica Chimica Acta
Saida Haider, Zehra Batool, Saara Ahmad, Rafat Ali Siddiqui, Darakhshan Jabeen Haleem
The brain is highly susceptible to the damaging effects of oxidative reactive species. The free radicals which are produced as a consequence of aerobic respiration can cause cumulative oxygen damage which may lead to age-related neurodegeneration. Scopolamine, the anti-muscarinic agent induces amnesia and oxidative stress similar to that observed in the older age. Studies suggest that antioxidants derived from plant products may provide protection against oxidative stress. Therefore, the present study was designed to investigate the attenuation of scopolamine-induced memory impairment and oxidative stress by walnut supplementation in rats...
October 12, 2017: Metabolic Brain Disease
Mallikarjuna Aradhya, Dianne Velasco, Zakir Ibrahimov, Biimyrza Toktoraliev, David Maghradze, Mirza Musayev, Zviadi Bobokashvili, John E Preece
The distribution and survival of trees during the last glacial maximum (LGM) has been of interest to paleoecologists, biogeographers, and geneticists. Ecological niche models that associate species occurrence and abundance with climatic variables are widely used to gain ecological and evolutionary insights and to predict species distributions over space and time. The present study deals with the glacial history of walnut to address questions related to past distributions through genetic analysis and ecological modeling of the present, LGM and Last Interglacial (LIG) periods...
2017: PloS One
Qingyong Li, Xiaoyan Kang, Chuanchao Shi, Yujuan Li, Kaustav Majumder, Zhengxiang Ning, Jiaoyan Ren
In this study, walnut meal hydrolysates (WMH) and dephenolized walnut meal hydrolysates (DWMH) were found to effectively decrease the serum uric acid level and protect the renal function in potassium oxonate-induced hyperuricemic rats in vivo as well as inhibit xanthine oxidase in vitro. Two novel antihyperuricemic peptides including WPPKN (640.8 Da) and ADIYTE (710.7 Da) were purified from DWMH via Sephadex G-15 gel filtration and reverse-phase high-performance liquid chromatography and identified by LC-ESI-MS/MS...
October 11, 2017: Food & Function
Hong Sub Lee, Kwang Jae Lee
Background/Aims: The role of dietary factors in the pathogenesis of irritable bowel syndrome (IBS) is still unclear. The aim of this study was to compare IgG4 levels to common food antigens between patients with IBS and healthy controls. Methods: Thirty-two patients diagnosed as IBS according to the Rome III criteria (12 diarrhea subgroup; 20 non-diarrhea subgroup) and 32 sex and age-matched healthy controls participated in the study. Serum IgG4 titers to 90 common foods were measured in each subject...
October 30, 2017: Journal of Neurogastroenterology and Motility
Hamdollah Delaviz, Jamshid Mohammadi, Ghasem Ghalamfarsa, Bahram Mohammadi, Naser Farhadi
In recent years, the use of medicinal plants increased considerably; so that today, the use of traditional medicine, as well as medicinal plants is necessary for the aim of producing more effective drugs with fewer side effects and determining the effective doses. With the scientific name of Juglans regia, walnut plant is a medicinal plant with different properties that is considered less, despite having great therapeutic potential in the traditional medicine. The aim of this study was to review the dispersal of walnut plants, the chemical compounds, and therapeutic effects of walnuts on antioxidant activity, antidiabetic, hypolipidemic, antimicrobial, and antihypertensive activities, as well as liver protection...
July 2017: Pharmacognosy Reviews
Mareen R Datema, Ronald van Ree, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frédéric de Blay, Michael Clausen, Ruta Dubakiene, Cristina Fernández-Perez, Philipp Fritsche, David Gislason, Karin Hoffmann-Sommergruber, Monika Jedrzejczak-Czechowicz, Laurian Jongejan, André C Knulst, Marek Kowalski, Tanya Z Kralimarkova, Thuy-My Le, Jonas Lidholm, Nikolaos G Papadopoulos, Todor A Popov, Nayade Del Prado, Ashok Purohit, Isabel Reig, Suranjith L Seneviratne, Athanassios Sinaniotis, Serge A Versteeg, Stefan Vieths, A H Zwinderman, E N Clare Mills, Montserrat Fernández-Rivas, Barbara Ballmer-Weber
BACKGROUND: Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity. AIM: To analyze associations between severity and sensitization patterns, patient characteristics and clinical history, and to develop models to improve predictive accuracy. METHODS: Patients reporting hazelnut allergy (n=423) from 12 European cities were tested for IgE against individual hazelnut allergens...
October 7, 2017: Allergy
(no author information available yet)
In the article "Changes in Aerobic Plate and Escherichia coli-Coliform Counts and in Populations of Inoculated Foodborne Pathogens on Inshell Walnuts during Storage" by J. C. Frelka, G. R. Davidson, and L. J. Harris, Journal of Food Protection 79(7):1143-1153, 2016, doi:10.4315/0362-028X.JFP-15-553, the sentence beginning in line 11 of the Abstract should read as follows: "Populations declined by 2.86, 5.01, and 4.40 log CFU per nut for Salmonella, E. coli O157:H7, and L. monocytogenes, respectively, after drying and during the first 8 days of storage...
October 2017: Journal of Food Protection
Charlotte Bamberger, Andreas Rossmeier, Katharina Lechner, Liya Wu, Elisa Waldmann, Renée G Stark, Julia Altenhofer, Kerstin Henze, Klaus G Parhofer
Studies indicate a positive association between walnut intake and improvements in plasma lipids. We evaluated the effect of an isocaloric replacement of macronutrients with walnuts and the time point of consumption on plasma lipids. We included 194 healthy subjects (134 females, age 63 ± 7 years, BMI 25.1 ± 4.0 kg/m²) in a randomized, controlled, prospective, cross-over study. Following a nut-free run-in period, subjects were randomized to two diet phases (8 weeks each). Ninety-six subjects first followed a walnut-enriched diet (43 g walnuts/day) and then switched to a nut-free diet...
October 6, 2017: Nutrients
Wenzhi Li, Tiantian Zhao, Jianan Zhang, Jucai Xu, Dongxiao Sun-Waterhouse, Mouming Zhao, Guowan Su
A walnut protein hydrolysate (WPH) was prepared by using a mixture of pancreatin and viscozyme L from industrially available defatted walnut meal. The antioxidant effects of WPH were confirmed and quantified by reducing power, oxygen radical absorbance capacity, hydroxyl radical radical-scavenging activity and ABTS(+)· radical-scavenging activity assays. The protective effects of WPH on scopolamine-induced learning and memory deficits in mice were also evaluated based on in vivo behavioral tests. Results showed that WPH administration would lead to significantly decreased latencies while increased crossing times and target times in the spatial probe test, and increased escape latency and decreased error times in the step-down avoidance test for the scopolamine-induced dementia mice...
September 2017: Journal of Food Science and Technology
Jackson Audley, William E Klingeman, Albert Mayfield, Scott Myers, Adam Taylor
Thousand cankers disease, caused by the invasive bark beetle Pityophthorus juglandis Blackman and an associated fungal pathogen Geosmithia morbida M.Kolařík, E. Freeland, C. Utley, N. Tisserat, currently threatens the health of eastern black walnut (Juglans nigra L.) in North America. Both the beetle and pathogen have expanded beyond their native range via transport of infested walnut wood. Geosmithia morbida can develop in seedlings following inoculation, but the ability of P. juglandis to colonize young, small diameter trees has not been investigated...
May 1, 2017: Journal of Insect Science
Julio Retamales, Cristopher Segovia, Romina Alvarado, Pablo Nuñez, Javier Santander
Here, we report the draft genome sequence of Xanthomonas arboricola pv. juglandis J303, isolated from infected walnut trees in southern Chile. The size of the genome is 5,066,424 bp with a G+C content of 65.4%. X. arboricola pv. juglandis J303 has several genes related to virulence, antibiotic resistance, and copper resistance.
September 28, 2017: Genome Announcements
William E Klingeman, Alicia M Bray, Jason B Oliver, Christopher M Ranger, Debra E Palmquist
Knowledge about which bark and ambrosia beetle species are active and at what heights in black walnut canopies is not well understood. Neither is the role of these beetles in spreading Thousand Cankers Disease. To assist with future planned research, which will assess the extent to which these beetle species are associated with Geosmithia morbida Kolařík, Freeland, Utley, and Tisserat (Ascomycota: Hypocreales: Bionectriaceae), experiments were undertaken to monitor bark and ambrosia beetles in urban landscapes and parks in Tennessee between 2011 and 2013...
September 7, 2017: Environmental Entomology
Zhong-Mei Wen, Jing Jie, Yuan Zhang, Han Liu, Li-Ping Peng
Lung cancer is a leading cause of cancer-associated mortality worldwide, which has a low survival rate. Multidrug resistance (MDR) is a major obstacle that hinders the treatment of lung cancer. Doxorubicin (DOX) is an anthracycline glycoside antibiotic, having a broad spectrum of anticancer activity against various solid tumors. Juglanin is a natural production, mainly extracted from green walnut husks of Juglans mandshurica, exhibiting various bioactivities. Here, we demonstrated that the combination of drug, gene and nanoparticle overcame MDR, inhibiting lung cancer progression...
September 25, 2017: Biochemical and Biophysical Research Communications
Somayeh Hosseinpour-Niazi, Shabnam Hosseini, Parvin Mirmiran, Fereidoun Azizi
This study aimed to assess the association of various types of nut per se, and total nut consumption with the incidence of metabolic syndrome (MetS). A 6.2 ± 0.7-year population-based prospective study was conducted among 1265 adults, aged 19-74 years, participants of the Tehran Lipid and Glucose Study. A 168-item semi-quantitative food frequency questionnaire was used to collect information on nut consumption. MetS was defined according to the Joint Interim Statement guidelines and 276 new cases of MetS were identified...
September 23, 2017: Nutrients
Shuang Song, Ling-Zhi Cheong, Hui Wang, Qing-Qing Man, Shao-Jie Pang, Yue-Qi Li, Biao Ren, Zhu Wang, Jian Zhang
Nuts, a class of fatty natural food, are associated with a series of health benefit. Lipid, which is the most abundant nutrient in nuts, could be one of the major contributors to many beneficial effects. In previous studies, only the composition of fatty acids was investigated. To better understand the nutritional value of nuts, phospholipids (PLs), with widely confirmed bioactivities, should be profiled as well. In this work, a HILIC-ESI-IT-TOF-MS system is applied to characterize PL profiles in six kinds of nut, including almonds, cashews, pecans, pistachios, walnuts and peanuts...
February 1, 2018: Food Chemistry
Wilman Carrillo, José Angel Gómez-Ruiz, Ana Lucia Ruiz, Jõao Ernesto Carvalho
Proteins from Juglans regia L. were isolated. Then, proteins were hydrolyzed with different enzymes. Antiproliferative activity of proteins and of the protein hydrolysates of J. regia L. were evaluated using the sulforhodamine B method. Glutelin and prolamin proteins presented a high antiproliferative activity against cancer cells PC-3 (prostate) and K-562 (leukemia) with values of 43.9 and 84.4 μg/mL, respectively. The highest inhibitory effect observed was 50% at 0.25 μg/mL concentration in gastrointestinal digestion with pepsin and corolase pp in a dose-dependent manner against cancer cell UACC62 (melanoma)...
September 25, 2017: Journal of Medicinal Food
Beatrycze Nowicka, Andrzej Żądło, Bartosz Pluciński, Jerzy Kruk, Paulina Kuczyńska
Allelopathy is a phenomenon, where one species releases compounds able to inhibit the growth of other species. Juglone, 5-hydroxy-1,4-naphtoquinone, is an allelochemical produced by walnut trees. The main mode of juglone toxicity is the formation of semiquinone radicals, able to reduce O2 to superoxide. Prenyllipid antioxidants such as tocopherol and plastoquinone are important for antioxidant defense in photosynthetic organisms. Here we assess their participation in the response to juglone. The impact of 20 μM juglone on the content of photosynthetic pigments and prenyllipid antioxidants in green microalga Chlamydomonas reinhardtii was measured over an incubation period of 7...
September 21, 2017: Phytochemistry
Emanuel Sarinho, Maria das Graças Moura Lins
OBJECTIVES: To guide the diagnostic and therapeutic management of severe forms of food allergy. DATA SOURCES: Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten years, searching in the title, abstract, or keyword fields. SUMMARY OF DATA: Food allergy can be serious and life-threatening...
September 21, 2017: Jornal de Pediatria
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