Yan Ning, Xinyue Dou, Zhichao Wang, Kao Shi, Zeping Wang, Chuan Ding, Xianan Sang, Xiang Zhong, Meiyu Shao, Xin Han, Gang Cao
Sirtuin3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+ )-dependent protein deacetylase located in the mitochondria, which mainly regulates the acetylation of mitochondrial proteins. In addition, SIRT3 is involved in critical biological processes, including oxidative stress, inflammation, DNA damage, and apoptosis, all of which are closely related to the progression of liver disease. Liver fibrosis characterized by the deposition of extracellular matrix is a result of long termed or repeated liver damage, frequently accompanied by damaged hepatocytes, the recruitment of inflammatory cells, and the activation of hepatic stellate cells...
March 30, 2024: Pharmacology & Therapeutics