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Adverse childhood events type 1 diabetes

Renske J Kuppens, Nienke E Bakker, Elbrich P C Siemensma, Roderick F A Tummers-de Lind van Wijngaarden, Stephany H Donze, Dederieke A M Festen, Janielle A E M van Alfen-van der Velden, Theo Stijnen, Anita C S Hokken-Koelega
CONTEXT: Patients with Prader-Willi syndrome (PWS) are severely at risk to develop morbid obesity, diabetes mellitus type 2 and cardiovascular disease, leading to high mortality. They have an increased fat mass (FM) and decreased lean body mass (LBM). During childhood, growth hormone (GH) treatment counteracts the natural course of increasing obesity. Discontinuation of GH treatment at attainment of adult height (AH) might deteriorate their improved clinical condition, while continuation might benefit them...
August 23, 2016: Journal of Clinical Endocrinology and Metabolism
Tineke J Crawford, Caroline A Crowther, Jane Alsweiler, Julie Brown
BACKGROUND: Gestational diabetes, glucose intolerance with onset or first recognition during pregnancy, is a rising problem worldwide. Both non-pharmacological and pharmacological approaches to the prevention of gestational diabetes have been, and continue to be explored. Myo-inositol, an isomer of inositol, is a naturally occurring sugar commonly found in cereals, corn, legumes and meat. It is one of the intracellular mediators of the insulin signal and correlated with insulin sensitivity in type 2 diabetes...
December 17, 2015: Cochrane Database of Systematic Reviews
Louisa J Ells, Emma Mead, Greg Atkinson, Eva Corpeleijn, Katharine Roberts, Russell Viner, Louise Baur, Maria-Inti Metzendorf, Bernd Richter
BACKGROUND: Child and adolescent overweight and obesity have increased globally, and are associated with significant short and long term health consequences. OBJECTIVES: To assess the effects of surgical interventions for treating obesity in childhood and adolescence. SEARCH METHODS: We searched the Cochrane Library, MEDLINE, PubMed, EMBASE as well as LILACS, ICTRP Search Portal and (all from database inception to March 2015)...
June 24, 2015: Cochrane Database of Systematic Reviews
Tomoyuki Kawamura, Tatsuhiko Urakami, Shigetaka Sugihara, Hey Sook Kim, Mie Mochizuki, Shin Amamiya
The efficacy of continuous subcutaneous insulin infusion (CSII) of the rapid-acting insulin analogue, insulin aspart, was evaluated in 26 patients with childhood-onset type 1 diabetes aged between 6 and 18 yr who had been on basal-bolus therapy (multiple daily injection (MDI) of regular human insulin or rapid-acting insulin and intermediate/long-acting insulin). The glycemic control in the patients was evaluated based on changes in the clinical parameters and the patient quality of life (QOL) was evaluated by using the insulin therapy-related QOL questionnaire...
2008: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
Pakize Karakaya, Sebnem Yılmaz, Ozlem Tüfekçi, Mustafa Kır, Ece Böber, Gülersu Irken, Hale Oren
OBJECTIVE: Survival rates for childhood acute lymphoblastic leukemia (ALL) have significantly improved and late effects of therapy have been important in the follow-up of survivors. The objective of this study is to identify the endocrinological and cardiological late effects of ALL patients treated in our pediatric hematology unit. MATERIALS AND METHODS: Patients treated for ALL with BFM protocols after at least 5 years of diagnosis and not relapsed were included in the study...
September 2013: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Timothy Lawes, Victoria Franklin, George Farmer
OBJECTIVES: To explore the association between HbA1c 6 months after diagnosis (6 m-HbA1c) and long-term glycaemic control in children with type 1 diabetes, accounting for other bio-psychosocial determinants. METHODS: This retrospective cohort study, included 155 children (≤16 yr) from the North of Scotland, diagnosed between January 1993 and August 2011, and receiving care between November 2008 and August 2012. Multilevel analysis explored the relationships between 6 m-HbA1c, other persistent or dynamic variables, and HbA1c...
August 2014: Pediatric Diabetes
Akira Shimatsu, Shigeru Tai, Makoto Imori, Katsuichiro Ihara, Masanori Taketsuna, Jumpei Funai, Toshiaki Tanaka, Akira Teramoto, Minoru Irie, Kazuo Chihara
This large-scale observational study examined the long-term effectiveness and safety of growth hormone (GH) replacement therapy for adult GH deficiency (GHD) in Japanese clinical practice using the Hypopituitary Control and Complications Study database. The study included 402 GHD patients for safety analyses and a subset of 209 patients (149 adult-onset and 60 childhood-onset GHD patients) who had not previously received GH replacement therapy for the efficacy analyses. Data on clinical, metabolic, quality of life (QoL) characteristics, and all adverse events (AEs) were collected at baseline (start of GH treatment), 6 months, 1 year and 2 years...
2013: Endocrine Journal
Thomas A Rasmussen, Martin R S Jørgensen, Stephanie Bjerrum, Søren Jensen-Fangel, Henrik Støvring, Lars Østergaard, Ole S Søgaard
OBJECTIVES: To predict the number of selected outcomes temporally associated but not caused by vaccination, to aid causality assessment of adverse events arising after mass immunisation in a paediatric population. DESIGN: Nationwide population based cohort study. SETTING: Denmark. PARTICIPANTS: All liveborn infants delivered after 1 January 1980. Study population was followed from date of birth until hospital admission for selected outcome diagnoses, death, first emigration, age 18 years, or 31 December 2009...
2012: BMJ: British Medical Journal
Julia K Townson, John W Gregory, David Cohen, Sue Channon, Nicola Harman, Justin H Davies, Justin Warner, Nicola Trevelyan, Rebecca Playle, Michael Robling, Kerenza Hood, Lesley Lowes
BACKGROUND: There is increased incidence of new cases of type 1 diabetes in children younger than 15 years. The debate concerning where best to manage newly diagnosed children continues. Some units routinely admit children to hospital whilst others routinely manage children at home. A Cochrane review identified the need for a large well-designed randomised controlled trial to investigate any significant differences in comprehensive short and long-term outcomes between the two approaches...
January 19, 2011: BMC Pediatrics
O Kordonouri, E Pankowska, B Rami, T Kapellen, R Coutant, R Hartmann, K Lange, M Knip, T Danne
AIMS/HYPOTHESIS: The value of managing children with type 1 diabetes using a combination of insulin pump and continuous glucose monitoring starting from diagnosis for improving subsequent glycaemic control and preserving residual beta cell function was determined. METHODS: A total of 160 children (aged 1-16 years, mean ± SD: 8.7 ± 4.4 years; 47.5% girls) were randomised to receive insulin pump treatment with continuous glucose monitoring or conventional self-monitoring blood glucose measurements...
December 2010: Diabetologia
Jyrki Korkeila, Jussi Vahtera, Katariina Korkeila, Mika Kivimäki, Markku Sumanen, Karoliina Koskenvuo, Markku Koskenvuo
BACKGROUND: Studies suggest that childhood adversities are important determinants of various types of later illnesses as well as poor health behaviour. However, few large-scale prospective studies have examined the associations between childhood adversities and cardiovascular disease. OBJECTIVE: To investigate whether childhood adversities are associated with increased risk of incident cardiovascular disease. DESIGN AND SETTING: Participants were 23 916 men and women in four age groups (20-24, 30-34, 40-44, and 50-54 years) from the Health and Social Support study, a longitudinal study on a random sample representative of the Finnish population...
February 2010: Heart: Official Journal of the British Cardiac Society
Marie L Misso, Kristine J Egberts, Matthew Page, Denise O'Connor, Jonathan Shaw
BACKGROUND: Type 1 diabetes is a metabolic disorder resulting from a defect in insulin secretion. Onset of type 1 diabetes mellitus may occur at any age and it is one of the most common chronic diseases of childhood and adolescence. Since there are no interventions known to prevent onset, it is vital that effective treatment regimes are available. Glycaemic control is maintained by replacement of insulin and may be in the form of 'conventional' insulin therapy (multiple injections per day) or continuous subcutaneous insulin infusion (CSII)...
2010: Cochrane Database of Systematic Reviews
J P Mullooly, J G Donahue, F DeStefano, J Baggs, E Eriksen
OBJECTIVES: To assess how well selected ICD-9-CM diagnosis codes predict adverse events; to model bias and power loss when vaccine safety analyses rely on unverified codes. METHODS: We extracted chart verification data for ICD-9-CM diagnosis codes from six Vaccine Safety Datalink (VSD) publications and modeled biases and power losses using positive predictive value (PPV) estimates and ranges of code sensitivity. RESULTS: Positive predictive values were high for type 1 diabetes (80%) in children, relative to WHO criteria, and intussusception (81%) in young children, relative to a standard published case definition...
2008: Methods of Information in Medicine
Katrina Bolar, Andrew R Hoffman, Thomas Maneatis, Barbara Lippe
CONTEXT: Turner syndrome (TS) affects more than 50,000 girls and women in the United States. The National Cooperative Growth Study (NCGS) has collected efficacy and safety data for 5220 TS children treated with recombinant human GH (rhGH) during the last 20 yr. OBJECTIVES: Our objective was to determine frequencies of specific targeted adverse events (AEs) and additional AEs of interest in TS patients. Corresponding safety data in non-TS patients or normal populations were compared for selected AEs...
February 2008: Journal of Clinical Endocrinology and Metabolism
Noel K Maclaren, Sahil Gujral, Svetlana Ten, Roja Motagheti
Insulin resistance (IR) in childhood has importance to the understanding and prevention of the growing epidemic of insulin resistance syndrome (IRS) in adults with attendant obesity, type 2 diabetes (T2DM), atherosclerotic diseases, hypertension, gout, non-alcoholic, steato-hepatitis (NASH), gall bladder disease, nephropathy, polycystic ovarian disease (PCOS), infertility and premature senility. The severity of IR and its' complications in children unfortunately and usually progresses in their pubertal transition to adulthood; affected young children are more likely than adults to have underlying causal monogenic disorders; the sequence of natural history and events give insights into disease pathogeneses, and optimal life style choices that last are best made during the early formative years...
2007: Cell Biochemistry and Biophysics
Cosimo Giannini, A Mohn, Francesco Chiarelli
Active life and physical fitness may represent the most effective strategies to prevent chronic diseases and to improve growth and development for children, including those with diabetes. Observational studies have demonstrated the association between life style and prevention of chronic diseases in the general population. These studies have been showed a reduction of morbidity for vascular diseases in trained subjects who present adequate cardiovascular fitness and practise regular exercise. The exercise-related protective effects may be mediated in part through components of the metabolic syndrome: improved insulin sensitivity, decreased weight and visceral fat accumulation, reduced low density lipoprotein (LDL) and triglycerides, increased high density lipoprotein (HDL), decreased blood pressure...
2006: Acta Bio-medica: Atenei Parmensis
B Milton, P Holland, M Whitehead
BACKGROUND: The incidence of childhood-onset (Type 1) diabetes is high, and increasing, particularly among the very young. The aim of this review was to determine the longer-term social consequences of having diabetes as a child and to determine whether adverse consequences are more severe for disadvantaged children. METHODS: Results from published and unpublished studies were synthesized narratively to examine the impact of diabetes on education, employment and income in adulthood...
August 2006: Diabetic Medicine: a Journal of the British Diabetic Association
E M Hodson, J F Knight, N S Willis, J C Craig
BACKGROUND: In nephrotic syndrome protein leaks from the blood to the urine through the glomeruli resulting in hypoproteinaemia and generalised oedema. Children with untreated nephrotic syndrome frequently die from infections. The majority of children with nephrotic syndrome respond to corticosteroids. However about 70% of children experience a relapsing course with recurrent episodes of oedema and proteinuria. Corticosteroid usage has reduced the mortality rate in childhood nephrotic syndrome to around 3%, with infection remaining the most important cause of death...
2004: Cochrane Database of Systematic Reviews
Thao P Bui, George A Werther, Fergus J Cameron
The number of episodes of diabetic ketoacidosis (DKA) is a significant outcome measure for diabetes care. We ascertained patterns of admission due to DKA over 15 yr to determine whether this indicator of diabetes care had improved in parallel with clinical practices. Between 1 January 1985 and 31 December 1999, 630 admissions were reviewed. We subanalyzed these admissions according to whether the patient was newly diagnosed, had infrequent episodes of DKA (non-relapsers) or had frequent (> or = 2/yr) episodes of DKA (relapsers)...
June 2002: Pediatric Diabetes
J N Harvey, B Allagoa
AIMS: To quantify the influence of childhood onset on long-term renal and retinal outcome in Type 1 diabetes. METHODS: We used a population-based diabetes register to identify all Type 1 patients diagnosed before age 15 from 1960 to 1982 and resident in a defined catchment area in 1999. Those diagnosed before age 5, aged 5-9 and 10-14 years were compared with a reference group diagnosed at age 21-25 years over the same period. RESULTS: Compared with adult-onset controls, proteinuria occurred earlier (P = 0...
January 2004: Diabetic Medicine: a Journal of the British Diabetic Association
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