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https://www.readbyqxmd.com/read/28329750/optoelectronic-plethysmography-in-clinical-practice-and-research-a-review
#1
Carlo Massaroni, Elena Carraro, Andrea Vianello, Sandra Miccinilli, Michelangelo Morrone, Irisz K Levai, Emiliano Schena, Paola Saccomandi, Silvia Sterzi, John W Dickinson, Samantha Winter, Sergio Silvestri
BACKGROUND: Optoelectronic plethysmography (OEP) is a non-invasive motion capture method to measure chest wall movements and estimate lung volumes. OBJECTIVES: To provide an overview of the clinical findings and research applications of OEP in the assessment of breathing mechanics across populations of healthy and diseased individuals. METHODS: A bibliographic research was performed with the terms "opto-electronic plethysmography," "optoelectronic plethysmography," and "optoelectronic plethysmograph" in 50 digital library and bibliographic search databases resulting in the selection of 170 studies...
March 23, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28320948/highly-oriented-photosynthetic-reaction-centers-generate-a-proton-gradient-in-synthetic-protocells
#2
Emiliano Altamura, Francesco Milano, Roberto R Tangorra, Massimo Trotta, Omar Hassan Omar, Pasquale Stano, Fabio Mavelli
Photosynthesis is responsible for the photochemical conversion of light into the chemical energy that fuels the planet Earth. The photochemical core of this process in all photosynthetic organisms is a transmembrane protein called the reaction center. In purple photosynthetic bacteria a simple version of this photoenzyme catalyzes the reduction of a quinone molecule, accompanied by the uptake of two protons from the cytoplasm. This results in the establishment of a proton concentration gradient across the lipid membrane, which can be ultimately harnessed to synthesize ATP...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28320606/autoantibodies-with-beta-adrenergic-activity-from-chronic-chagasic-patients-induce-cardiac-arrhythmias-and-early-afterdepolarization-in-a-drug-induced-lqt2-rabbit-hearts
#3
Marco Antonio Vidal Jiménez, José H M Nascimento, Gustavo Monnerat, Leonardo Maciel, Claudia N Paiva, Roberto Coury Pedrosa, Antonio C Campos de Carvalho, Emiliano Medei
BACKGROUND: Cardiac arrhythmias are one of the main causes of death in ChCP and other dilated cardiomyopathies. Previous studies demonstrated that ventricular arrhythmias are associated with the presence of autoantibodies with beta-adrenergic activity, Ab-β. OBJECTIVES: The aim of this study was to investigate whether Ab-β, present in chronic chagasic patients (ChCP), induce cardiac arrhythmias in the pharmacological type-2 long QT syndrome model (LQTS-2). METHODS/RESULTS: The LQTS2 was established by perfusion of Tyrode saline solution with a potassium channel blocker E-4031 (5μM) in isolated rabbit hearts or in rabbit cardiac strips, in order to record ECG or action potential, respectively...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28320252/the-impact-of-laser-surgery-on-angiogenic-and-anti-angiogenic-factors-in-twin-twin-transfusion-syndrome-a-prospective-study
#4
Andrew H Chon, Emiliano R Chavira, Melissa L Wilson, Sue A Ingles, Arlyn Llanes, Ramen H Chmait
OBJECTIVE: To examine the effect of laser surgery on angiogenic and anti-angiogenic factors in patients with twin-twin transfusion syndrome (TTTS). METHODS: Cases of TTTS and uncomplicated monochorionic diamniotic twin pregnancies between 16-26 weeks' gestation were prospectively enrolled into the study. Maternal blood samples were obtained to measure angiogenic factors (vascular endothelial growth factor-A (VEGF), placental-derived growth factor (PlGF), endothelin) and anti-angiogenic factors (soluble fms-like tyrosine kinase (sFlt-1), soluble endoglin (sEng), sFlt-1/PlGF ratio)...
March 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28317645/the-biomarker-based-diagnosis-of-alzheimer-s-disease-2-lessons-from-oncology
#5
REVIEW
Marina Boccardi, Valentina Gallo, Yutaka Yasui, Paolo Vineis, Alessandro Padovani, Urs Mosimann, Panteleimon Giannakopoulos, Gabriel Gold, Bruno Dubois, Clifford R Jack, Bengt Winblad, Giovanni B Frisoni, Emiliano Albanese
Biomarkers for the diagnosis of Alzheimer's disease (AD) are not yet validated for use in clinical settings. We aim to provide a methodological framework for their systematic validation, by reference to that developed for oncology biomarkers. As for this discipline, the steps for the systematic validation of AD biomarkers need to target analytical validity, clinical validity, and clinical utility. However, the premises are different from oncology: the nature of disease (neurodegeneration vs. cancer), the purpose (improve diagnosis in clinically affected vs...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28317644/the-biomarker-based-diagnosis-of-alzheimer-s-disease-1-ethical-and-societal-issues
#6
REVIEW
Corinna Porteri, Emiliano Albanese, Charles Scerri, Maria C Carrillo, Heather M Snyder, Birgitta Martensson, Mark Baker, Ezio Giacobini, Marina Boccardi, Bengt Winblad, Giovanni B Frisoni, Samia Hurst
There is great interest in the use of biomarkers to assist in the timely identification of Alzheimer's disease (AD) in individuals with mild symptoms. However, the inclusion of AD biomarkers in clinical criteria poses socioethical challenges. The Geneva Task Force for the Roadmap of Alzheimer's Biomarkers was established to deliver a systematic strategic research agenda (aka roadmap) to promote efficient and effective validation of AD biomarkers and to foster their uptake in clinical practice. In this article, we summarize the workshop discussion of the Geneva Task Force "ethical and societal issues" working group, which comprised bioethicists, clinicians, health economists, and representatives of those affected by AD...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28317241/organogels-from-double-chained-vitamin-c-amphiphilic-derivatives
#7
Pierandrea Lo Nostro, Elia Tempestini, Martina Bucci, Vincenzo Mastromartino, Marianna Gori, Damiano Tanini, Moira Ambrosi, Emiliano Fratini, Antonella Capperucci
We report on the synthesis and physico-chemical characterization of double chained amphiphilic compounds obtained from vitamin C: Di-alkanoyl-5,6-O-ascorbic acid esters, Di-ASCn, with n = 8, 10 and 12. The acetyl-5-dodecanoyl-6-ascorbic acid ester was synthesized and investigated for comparison. These products are quite insoluble in water and in polar solvents, while they form homogeneous dispersions in cyclohexane. By cooling, these dispersions turn into a gel-like phase. DSC, FTIR, and SAXS/WAXS experiments were carried out to investigate the properties of the pure solids and of their liquid dispersions...
March 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28293868/engineering-s-equi-subsp-zooepidemicus-towards-concurrent-production-of-hyaluronic-acid-and-chondroitin-biopolymers-of-biomedical-interest
#8
Donatella Cimini, Ileana Dello Iacono, Elisabetta Carlino, Rosario Finamore, Odile F Restaino, Paola Diana, Emiliano Bedini, Chiara Schiraldi
Glycosaminoglycans, such as hyaluronic acid and chondroitin sulphate, are not only more and more required as main ingredients in cosmeceutical and nutraceutical preparations, but also as active principles in medical devices and pharmaceutical products. However, while biotechnological production of hyaluronic acid is industrially established through fermentation of Streptococcus spp. and recently Bacillus subtilis, biotechnological chondroitin is not yet on the market. A non-hemolytic and hyaluronidase negative S...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28287194/-modifiche-morfo-volumetriche-dopo-trattamento-emdr-in-pazienti-drug-na%C3%A3-ve-affetti-da-dpts
#9
Letizia Bossini, Emiliano Santarnecchi, Ilaria Casolaro, Despoina Koukouna, Claudia Caterini, Federica Cecchini, Valentina Fortini, Giampaolo Vatti, Daniela Marino, Isabel Fernandez, Alessandro Rossi, Andrea Fagiolini
RIASSUNTO. Introduzione. Esistono pochi studi che hanno indagato gli effetti di una psicoterapia ritenuta efficace sulle alterazioni strutturali delle regioni cerebrali associate al disturbo da stress post-traumatico (PTSD). Ci siamo, pertanto, proposti di valutare gli effetti neurobiologici della terapia EMDR su un gruppo di 19 pazienti con PTSD, senza cura farmacologica e senza alcuna comorbidità con altri disturbi psichiatrici, a confronto con un gruppo di controllo costituito da 19 soggetti sani non trattati...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28279731/precuneus-proportions-and-cortical-folding-a-morphometric-evaluation-on-a-racially-diverse-human-sample
#10
Emiliano Bruner, Ana Sofia Pereira-Pedro, Xu Chen, James K Rilling
Recent analyses have suggested that the size and proportions of the precuneus are remarkably variable among adult humans, representing a major source of geometrical difference in midsagittal brain morphology. The same area also represents the main midsagittal brain difference between humans and chimpanzees, being more expanded in our species. Enlargement of the upper parietal surface is a specific feature of Homo sapiens, when compared with other fossil hominids, suggesting the involvement of these cortical areas in recent modern human evolution...
March 6, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28274764/how-much-does-it-cost-to-look-like-a-pig-in-a-wild-boar-group
#11
Daniele Battocchio, Laura Iacolina, Antonio Canu, Emiliano Mori
Hybridization between domestic and wild species is known to widely occur and it is reported to be one of the major causes of the current biodiversity crisis. Despite this, poor attention has been deserved to the behavioural ecology of hybrids, in particular in relation to their social behaviour. We carried out a camera trap study to assess whether phenotypically anomalous colouration in wild boar, i.e. potentially introgressed with domestic pigs, affected the hierarchical structure of wild boar social groups...
March 6, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28264755/maternal-low-protein-diet-in-female-rat-heart-possible-protective-effect-of-estradiol
#12
G R F Braz, A S Emiliano, S M Sousa, A A S Pedroza, D F Santana, M P Fernandes, A I da Silva, C J Lagranha
Several studies have shown that maternal low-protein (LP) diet induces detrimental effects in cardiovascular system and oxidative stress in male animals. Additional studies suggested that female has lower incidence of cardiovascular disease. However until present data, the possible effects of estradiol on the undernutrition during gestational and lactation periods are not discussed. The present study was conducted to evaluate the effects of a maternal LP diet during gestational and lactation period on oxidative balance in the female rat hearts ventricles at two ages...
March 7, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28263221/torque-teno-virus-load-and-acute-rejection-after-orthotopic-liver-transplantation
#13
Federico Simonetta, Amandine Pradier, Stavroula Masouridi-Levrat, Christian van Delden, Emiliano Giostra, Isabelle Morard, Nicolas Müller, Beat Müllhaupt, Piero V Valli, Nasser Semmo, Jörg Seebach, Yves Chalandon, Laurent Kaiser, Eddy Roosnek
No abstract text is available yet for this article.
March 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28251649/evidence-for-purine-nucleoside-phosphorylase-pnp-release-from-rat-c6-glioma-cells
#14
Patricia Giuliani, Mariachiara Zuccarini, Silvana Buccella, Luis Emiliano Peña-Altamira, Elisabetta Polazzi, Marco Virgili, Barbara Monti, Alessandro Poli, Michel P Rathbone, Patrizia Di Iorio, Renata Ciccarelli, Francesco Caciagli
Intracellular purine turnover is mainly oriented to preserving the level of triphosphate nucleotides, fundamental molecules in vital cell functions that, when released outside cells, act as receptor signals. Conversely, high levels of purine bases and uric acid are found in the extracellular milieu, even in resting conditions. These compounds could derive from nucleosides/bases that, having escaped to cell reuptake, are metabolized by extracellular enzymes similar to the cytosolic ones. Focusing on purine nucleoside phosphorylase (PNP) that catalyzes the reversible phosphorolysis of purine (deoxy)-nucleosides/bases, we found that it is constitutively released from cultured rat C6 glioma cells into the medium, and has a molecular weight and enzyme activity similar to the cytosolic enzyme...
March 2, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28251044/chemically-selective-alternatives-to-photoferroelectrics-for-polarization-enhanced-photocatalysis-the-untapped-potential-of-hybrid-inorganic-nanotubes
#15
Joshua D Elliott, Emiliano Poli, Ivan Scivetti, Laura E Ratcliff, Lampros Andrinopoulos, Jacek Dziedzic, Nicholas D M Hine, Arash A Mostofi, Chris-Kriton Skylaris, Peter D Haynes, Gilberto Teobaldi
Linear-scaling density functional theory simulation of methylated imogolite nanotubes (NTs) elucidates the interplay between wall-polarization, bands separation, charge-transfer excitation, and tunable electrostatics inside and outside the NT-cavity. The results suggest that integration of polarization-enhanced selective photocatalysis and chemical separation into one overall dipole-free material should be possible. Strategies are proposed to increase the NT polarization for maximally enhanced electron-hole separation...
February 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28249719/ionic-liquid-assisted-separation-and-determination-of-selenium-species-in-food-and-beverage-samples-by-liquid-chromatography-coupled-to-hydride-generation-atomic-fluorescence-spectrometry
#16
Alexander Castro Grijalba, Emiliano F Fiorentini, Rodolfo G Wuilloud
Different ionic liquids (ILs) were assayed as mobile phase modifiers for the separation and determination of selenite [Se(IV)], selenate [Se(VI)], selenomethionine (SeMet) and Se-methylselenocysteine (SeMeSeCys) by reversed-phase high-performance liquid chromatography coupled to hydride generation atomic fluorescence spectrometry (RP-HPLC-HG-AFS). The use of several ILs: 1-butyl-3-methylimidazolium chloride, 1-hexyl-3-methylimidazolium chloride ([C6mim]Cl), 1-octyl-3-methylimidazolium chloride, 1-dodecyl-3-methylimidazolium bromide, 1-hexadecyl-3-methylimidazolium bromide and tributyl(methyl)phosphonium methylsulphate was evaluated...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28235644/down-regulation-of-the-mitochondrial-aspartate-glutamate-carrier-isoform-1-agc1-inhibits-proliferation-and-n-acetylaspartate-synthesis-in-neuro2a-cells
#17
Emanuela Profilo, Luis Emiliano Peña-Altamira, Mariangela Corricelli, Alessandra Castegna, Alberto Danese, Gennaro Agrimi, Sabrina Petralla, Giulia Giannuzzi, Vito Porcelli, Luigi Sbano, Carlo Viscomi, Francesca Massenzio, Erika Mariana Palmieri, Carlotta Giorgi, Giuseppe Fiermonte, Marco Virgili, Luigi Palmieri, Massimo Zeviani, Paolo Pinton, Barbara Monti, Ferdinando Palmieri, Francesco Massimo Lasorsa
The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) catalyzes a Ca(2+)-stimulated export of aspartate to the cytosol in exchange for glutamate, and is a key component of the malate-aspartate shuttle which transfers NADH reducing equivalents from the cytosol to mitochondria. By sustaining the complete glucose oxidation, AGC1 is thought to be important in providing energy for cells, in particular in the CNS and muscle where this protein is mainly expressed. Defects in the AGC1 gene cause AGC1 deficiency, an infantile encephalopathy with delayed myelination and reduced brain N-acetylaspartate (NAA) levels, the precursor of myelin synthesis in the CNS...
February 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28231477/effects-of-tdcs-on-motor-learning-and-memory-formation-a-consensus-and-critical-position-paper
#18
REVIEW
Ethan R Buch, Emiliano Santarnecchi, Andrea Antal, Jan Born, Pablo A Celnik, Joseph Classen, Christian Gerloff, Mark Hallett, Friedhelm C Hummel, Michael A Nitsche, Alvaro Pascual-Leone, Walter J Paulus, Janine Reis, Edwin M Robertson, John C Rothwell, Marco Sandrini, Heidi M Schambra, Eric M Wassermann, Ulf Ziemann, Leonardo G Cohen
Motor skills are required for activities of daily living. Transcranial direct current stimulation (tDCS) applied in association with motor skill learning has been investigated as a tool for enhancing training effects in health and disease. Here, we review the published literature investigating whether tDCS can facilitate the acquisition, retention or adaptation of motor skills. Work in multiple laboratories is underway to develop a mechanistic understanding of tDCS effects on different forms of learning and to optimize stimulation protocols...
April 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28231093/identification-of-the-geographic-origin-of-parmigiano-reggiano-p-d-o-cheeses-deploying-non-targeted-mass-spectrometry-and-chemometrics
#19
Bert Popping, Emiliano De Dominicis, Mario Dante, Marco Nocetti
Parmigiano Reggiano is an Italian product with a protected designation of origin (P.D.O.). It is an aged hard cheese made from raw milk. P.D.O. products are protected by European regulations. Approximately 3 million wheels are produced each year, and the product attracts a relevant premium price due to its quality and all around the world well known typicity. Due to the high demand that exceeds the production, several fraudulent products can be found on the market. The rate of fraud is estimated between 20% and 40%, the latter predominantly in the grated form...
February 16, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28225783/heart-and-skeletal-muscle-inflammation-hsmi-disease-diagnosed-on-a-british-columbia-salmon-farm-through-a-longitudinal-farm-study
#20
Emiliano Di Cicco, Hugh W Ferguson, Angela D Schulze, Karia H Kaukinen, Shaorong Li, Raphaël Vanderstichel, Øystein Wessel, Espen Rimstad, Ian A Gardner, K Larry Hammell, Kristina M Miller
Heart and skeletal muscle inflammation (HSMI) is an emerging disease of marine-farmed Atlantic Salmon (Salmo salar), first recognized in 1999 in Norway, and later also reported in Scotland and Chile. We undertook a longitudinal study involving health evaluation over an entire marine production cycle on one salmon farm in British Columbia (Canada). In previous production cycles at this farm site and others in the vicinity, cardiac lesions not linked to a specific infectious agent or disease were identified. Histologic assessments of both live and moribund fish samples collected at the farm during the longitudinal study documented at the population level the development, peak, and recovery phases of HSMI...
2017: PloS One
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