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Jorge E Mancini, Gustavo Ortiz, Constanza Potilinstki, Juan P Salica, Emiliano S Lopez, J Oscar Croxatto, Juan E Gallo
Background: Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, there is a constant ATP production and this rise of ATP leads to a persistent activation of purinergic receptors. Antagonists of these receptors are used to evaluate their inhibition effects. Recently, the P2X2 has been reported to have a neuroprotective role...
2018: Diabetology & Metabolic Syndrome
Francesca Mensitieri, Federica De Lise, Andrea Strazzulli, Marco Moracci, Eugenio Notomista, Valeria Cafaro, Emiliano Bedini, Matthew Howard Sazinsky, Marco Trifuoggi, Alberto Di Donato, Viviana Izzo
α-L-Rhamnosidases (α-RHAs, EC are glycosyl hydrolases (GHs) hydrolyzing terminal α-L-rhamnose residues from different substrates such as heteropolysaccharides, glycosylated proteins and natural flavonoids. Although the possibility to hydrolyze rhamnose from natural flavonoids has boosted the use of these enzymes in several biotechnological applications over the past decades, to date only few bacterial rhamnosidases have been fully characterized and only one crystal structure of a rhamnosidase of the GH106 family has been described...
April 17, 2018: Archives of Biochemistry and Biophysics
Emiliano F Fiorentini, Leticia B Escudero, Rodolfo G Wuilloud
A simple, highly efficient, batch, and centrifuge-less dispersive liquid-liquid microextraction method based on a magnetic ionic liquid (MIL-DLLME) and electrothermal atomic absorption spectrometry (ETAAS) detection was developed for ultra-trace Cd determination in honey. Initially, Cd(II) was chelated with ammonium diethyldithiophosphate (DDTP) at pH 0.5 followed by its extraction with the MIL trihexyl(tetradecyl)phosphonium tetrachloroferrate(III) ([P6,6,6,14 ]FeCl4 ) and acetonitrile as dispersant. The MIL phase containing the analyte was separated from the aqueous phase using only a magnet...
April 19, 2018: Analytical and Bioanalytical Chemistry
Emiliano Chisci, Linda Harris, Azzurra Guidotti, Angelica Pecchioli, Clara Pigozzi, Enrico Barbanti, Leonardo Ercolini, Stefano Michelagnoli
OBJECTIVES: The aim of this study was to define the safety and effectiveness of a contrast enhanced ultrasound (CEUS) based follow up for endovascular aortic repair (EVAR) surveillance at a mid-term period (4 years). METHODS: At the tertiary referral centre EVAR surveillance was based on plain abdominal radiograph and duplex ultrasound (CDU), with computed tomography angiography (CTA) reserved for any non-diagnostic imaging during the period 1999-2011 (Group A)...
April 17, 2018: European Journal of Vascular and Endovascular Surgery
Emiliano Schena, Daniele Tosi, Paola Saccomandi, Elfed Lewis, Taesung Kim
The author wishes to make the following correction to this paper [1], and to replace Figure 2:[...].
April 17, 2018: Sensors
Claudia N Paiva, Emiliano Medei, Marcelo T Bozza
The activation of macrophage respiratory burst in response to infection with Trypanosoma cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen species (ROS) in the elimination of T. cruzi was taken for granted, but recent evidence suggests parasite growth is stimulated in oxidative environments. It is still a matter of debate whether indeed oxidative environments provide ideal conditions (e.g., iron availability in macrophages) for T. cruzi growth and whether indeed ROS signals directly to stimulate growth...
April 2018: PLoS Pathogens
Christian Fisahn, Cameron Schmidt, Josh E Schroeder, Emiliano Vialle, Isador H Lieberman, Joseph R Dettori, Thomas A Schildhauer
Study Design: Systematic review. Objectives: Allogeneic blood transfusion-related immunomodulation may relatively suppress the immune system, heightening the risk of infection following spine surgery. This systematic review seeks to determine whether allogeneic blood transfusion increases the risk of postoperative infection and whether there are any factors that modify this association. Methods: PubMed, Cochrane Central Register of Controlled Trials, and reference lists from included studies were searched from inception to April 20, 2017 to identify studies examining the risk of infection following allogeneic blood transfusion in adult patients receiving surgery for degenerative spine disease...
April 2018: Global Spine Journal
Luisana Corsuto, Sandra Rother, Linda Koehler, Emiliano Bedini, Stephanie Moeller, Matthias Schnabelrauch, Vera Hintze, Chiara Schiraldi, Dieter Scharnweber
Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-β1 (TGF-β1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-β signaling. However, the impact of CS on keratinocytes is unknown. Especially biotechnological-chemical strategies are promising to replace animal-derived CS. Thus, this study aims to evaluate the effects of CS derivatives on the interaction with vascular endothelial growth factor-A (VEGF-A) and on keratinocyte response...
July 1, 2018: Carbohydrate Polymers
Alyne Mara Rodrigues de Carvalho, Leonardo Freire Vasconcelos, Nayrton Flávio Moura Rocha, Emiliano Ricardo Vasconcelos Rios, Marília Leite Dias, Marta Maria de França Fonteles, Danielle Macêdo Gaspar, José Maria Barbosa Filho, Stanley Juan Chavez Gutierrez, Francisca Cléa Florenço de Sousa
Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-α and IL-1β production and its histamine antagonism. The objective of this study was to evaluate the role of RipII in the pain process and the possible antinociceptive mechanisms involved, using classic models of nociception. Male Swiss mice were used in the assays. Determinate the acute toxicity according to the OECD 425 test guideline. The models used were the acetic acid-, formalin-, hot plate and glutamate-induced nociception...
April 12, 2018: Chemico-biological Interactions
Paolo Scimia, Erika Basso Ricci, Emiliano Petrucci, Astrid Ursula Behr, Franco Marinangeli, Pierfrancesco Fusco
Ultrasound (US)-guided transversalis fascia plane block (TFPB) was first described by Hebbard as a technique for blockade of T12-L1 nerves. Although this technique appears similar to the quadratus lumborum 1 block, the point of injection is more caudal and anterior, specifically targeting ilioinguinal and iliohypogastric nerves. There are only few published data on US-guided TFPB demonstrating effective postoperative analgesia in iliac crest bone graft harvesting. We report the use of US-guided TFPB in a patient undergoing inguinal herniorrhaphy...
April 15, 2018: A&A practice
Pietro Quaglio, Vahid Rostami, Emiliano Torre, Sonja Grün
Temporally, precise correlations between simultaneously recorded neurons have been interpreted as signatures of cell assemblies, i.e., groups of neurons that form processing units. Evidence for this hypothesis was found on the level of pairwise correlations in simultaneous recordings of few neurons. Increasing the number of simultaneously recorded neurons increases the chances to detect cell assembly activity due to the larger sample size. Recent technological advances have enabled the recording of 100 or more neurons in parallel...
April 12, 2018: Biological Cybernetics
Anna-Katharine Brem, Jessamy Norton-Ford Almquist, Karen Mansfield, Franziska Plessow, Francesco Sella, Emiliano Santarnecchi, Umut Orhan, James McKanna, Misha Pavel, Santosh Mathan, Nick Yeung, Alvaro Pascual-Leone, Roi Cohen Kadosh, On Behalf Of Honeywell Sharp Team Authors
It is debated whether cognitive training of specific executive functions leads to far transfer effects, such as improvements in fluid intelligence (Gf). Within this context, transcranial direct current stimulation and recently also novel protocols such as transcranial random noise and alternating current stimulation are being investigated with regards to their ability to enhance cognitive training outcomes. We compared the effects of four different transcranial electrical brain stimulation protocols in combination with nine daily computerized training sessions on Gf...
April 9, 2018: Neuropsychologia
Craig Parkinson, Kieran Foley, Philip Whybra, Robert Hills, Ashley Roberts, Chris Marshall, John Staffurth, Emiliano Spezi
BACKGROUND: Prognosis in oesophageal cancer (OC) is poor. The 5-year overall survival (OS) rate is approximately 15%. Personalised medicine is hoped to increase the 5- and 10-year OS rates. Quantitative analysis of PET is gaining substantial interest in prognostic research but requires the accurate definition of the metabolic tumour volume. This study compares prognostic models developed in the same patient cohort using individual PET segmentation algorithms and assesses the impact on patient risk stratification...
April 11, 2018: EJNMMI Research
Paolo Scimia, Carolina Giordano, Erika Basso Ricci, Emiliano Petrucci, Pierfrancesco Fusco
No abstract text is available yet for this article.
April 5, 2018: Minerva Anestesiologica
Davide Tassinari, Chiara Cherubini, Britt Roudnas, Emiliano Tamburini, Fabrizio Drudi, Emanuela Bianchi, Manuela Fantini, Francesco Montanari, Sergio Sartori
INTRODUCTION: To compare the efficacy of abiraterone acetate, enzalutamide, cabazitaxel and Radium-223 in the treatment of castration-resistant, docetaxel-resistant metastatic prostate cancer. METHODS: An indirect comparison of overall survival (OS) and time to PSA progression among abiraterone acetate, enzalutamide, cabazitaxel and Radium-223 was performed with a network meta-analysis. OS in the entire population of patients was the primary end point. OS in ECOG 0-1/2, BPI-SF≤4/>4, pretreated with 1 or 2 courses of chemotherapy, age≤65/>65 patients, patients with only bone metastases or bone and visceral metastases, and time to PSA progression were the secondary end points...
April 4, 2018: Reviews on Recent Clinical Trials
Diorney Luiz Souza Gran da Silva, Mariana Lopes de Freitas, Gustavo Monnerat Cahil, Vitória Santório de São José, Felippe Mousovich Neto, Ricardo Cortez Cardoso, Vânia Maria Correa da Costa, Rodrigo Soares Fortunato, Denise Pires de Carvalho, Emiliano Horácio Medei, Andrea Claudia Freitas Ferreira
Cell therapy with mesenchymal stem cells (MSC) has been proposed for the treatment of diabetes mellitus (DM). It is known that the prevalence of thyroid disease is higher among diabetic patients than in general population. Therefore, our aim was to investigate the effect of the treatment with MSC on thyroid function and ROS generation in an experimental model of type 1 DM. Adult male Wistar rats were divided into the following groups: control, DM (80 mg/kg BW streptozotocin, iv.) and DM+MSC. MSC treatment occurred 4 weeks after DM induction and the animals were euthanized 4 weeks after MSC administration...
April 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Louis J Cohen, Daria Esterhazy, Seong-Hwan Kim, Christophe Lemetre, Rhiannon R Aguilar, Emma A Gordon, Amanda J Pickard, Justin R Cross, Ana B Emiliano, Sun M Han, John Chu, Xavier Vila-Farres, Jeremy Kaplitt, Aneta Rogoz, Paula Y Calle, Craig Hunter, J Kipchirchir Bitok, Sean F Brady
This corrects the article DOI: 10.1038/nature23874.
April 4, 2018: Nature
Michele Emiliano, Barbara Valenzano, Giammarco Surico, Prisco Piscitelli, Eduardo Missoni
No abstract text is available yet for this article.
February 2018: Lancet. Planetary Health
Jianling Xiao, Hanlin Fang, Rongbin Su, Kezheng Li, Jindong Song, Thomas F Krauss, Juntao Li, Emiliano R Martins
It is now well established that light trapping is an essential element of thin film solar cell design. Numerous light trapping geometries have already been applied to thin film cells, especially to silicon-based devices. Less attention has been paid to light trapping in GaAs thin film cells, mainly because light trapping is considered less attractive due to the material's direct bandgap and the fact that GaAs suffers from strong surface recombination, which particularly affects etched nanostructures. Here, we study light trapping structures that are implemented in a high-bandgap material on the back of the GaAs active layer, thereby not perturbing the integrity of the GaAs active layer...
March 19, 2018: Optics Express
Mario Muto, Giulia Frauenfelder, Rossana Senese, Fabio Zeccolini, Emiliano Schena, Francesco Giurazza, Hans Rolf Jäger
In the original publication of the article, the name of the last author was incorrect. The correct name should read as given below.
March 31, 2018: La Radiologia Medica
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