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https://www.readbyqxmd.com/read/29452076/feasibility-of-eus-guided-nd-yag-laser-ablation-of-unresectable-pancreatic-adenocarcinoma
#1
Francesco Maria Di Matteo, Paola Saccomandi, Margareth Martino, Monica Pandolfi, Margherita Pizzicannella, Valerio Balassone, Emiliano Schena, Claudio Marcello Pacella, Sergio Silvestri, Guido Costamagna
BACKGROUND AND AIMS: Endoscopic ultrasound (EUS) has become an interventional technique in which a needle may be used as a vehicle to deliver therapeutic agents. Laser ablation (LA) has been used to treat many primary and secondary neoplasms. This study aimed to assess the feasibility of EUS-guided LA for unresectable (UR) pancreatic cancer. METHODS: Patients with a stage IIb-III pancreatic cancer underwent EUS-guided LA. All patients were unresponsive to previous chemo-radiotherapy...
February 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29447827/a-novel-approach-for-comparing-patterns-of-foreign-body-injuries-across-countries-a-case-study-comparing-european-countries-and-bosnia-and-herzegovina
#2
Giulia Lorenzoni, Sekib Umihanić, Danila Azzolina, Emiliano Manza, Fuad Brkić, Dario Gregori
OBJECTIVES: The present study aimed at analyzing the characteristics of FB injuries from Bosnia and Herzegovina (B&H), a rapidly growing newly industrialized country, and to compare them with cases from European countries. METHODS: The analysis is based on FB injury cases included in the Susy Safe registry. Cases from the Ear-Nose-Throat (ENT) Clinic, University Clinical Center of Tuzla (B&H) were compared with cases from European countries participating in the Susy Safe project...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447226/barriers-and-facilitators-to-antiretroviral-therapy-adherence-among-peruvian-adolescents-living-with-hiv-a-qualitative-study
#3
Jerome T Galea, Milagros Wong, Maribel Muñoz, Emiliano Valle, Segundo R Leon, Dayana Díaz Perez, Lenka Kolevic, Molly Franke
AIDS deaths among adolescents are increasing globally. This qualitative study investigated the barriers and facilitators to cART adherence among Peruvian adolescents living with HIV. Guided by a social ecological model, we analyzed transcripts from 24 psychosocial support groups for HIV-positive adolescents aged 13-17 years and 15 individual, in-depth interviews with cART providers and caregivers to identify the barriers and facilitators to cART adherence at the individual, family/caregiver and hospital levels...
2018: PloS One
https://www.readbyqxmd.com/read/29435256/specific-plasmid-patterns-and-high-rates-of-bacterial-co-occurrence-within-the-coral-holobiont
#4
Deborah C A Leite, Joana F Salles, Emiliano N Calderon, Jan D van Elsas, Raquel S Peixoto
Despite the importance of coral microbiomes for holobiont persistence, the interactions among these are not well understood. In particular, knowledge of the co-occurrence and taxonomic importance of specific members of the microbial core, as well as patterns of specific mobile genetic elements (MGEs), is lacking. We used seawater and mucus samples collected from Mussismilia hispida colonies on two reefs located in Bahia, Brazil, to disentangle their associated bacterial communities, intertaxa correlations, and plasmid patterns...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29434652/the-open-abdomen-in-trauma-and-non-trauma-patients-wses-guidelines
#5
REVIEW
Federico Coccolini, Derek Roberts, Luca Ansaloni, Rao Ivatury, Emiliano Gamberini, Yoram Kluger, Ernest E Moore, Raul Coimbra, Andrew W Kirkpatrick, Bruno M Pereira, Giulia Montori, Marco Ceresoli, Fikri M Abu-Zidan, Massimo Sartelli, George Velmahos, Gustavo Pereira Fraga, Ari Leppaniemi, Matti Tolonen, Joseph Galante, Tarek Razek, Ron Maier, Miklosh Bala, Boris Sakakushev, Vladimir Khokha, Manu Malbrain, Vanni Agnoletti, Andrew Peitzman, Zaza Demetrashvili, Michael Sugrue, Salomone Di Saverio, Ingo Martzi, Kjetil Soreide, Walter Biffl, Paula Ferrada, Neil Parry, Philippe Montravers, Rita Maria Melotti, Francesco Salvetti, Tino M Valetti, Thomas Scalea, Osvaldo Chiara, Stefania Cimbanassi, Jeffry L Kashuk, Martha Larrea, Juan Alberto Martinez Hernandez, Heng-Fu Lin, Mircea Chirica, Catherine Arvieux, Camilla Bing, Tal Horer, Belinda De Simone, Peter Masiakos, Viktor Reva, Nicola DeAngelis, Kaoru Kike, Zsolt J Balogh, Paola Fugazzola, Matteo Tomasoni, Rifat Latifi, Noel Naidoo, Dieter Weber, Lauri Handolin, Kenji Inaba, Andreas Hecker, Yuan Kuo-Ching, Carlos A Ordoñez, Sandro Rizoli, Carlos Augusto Gomes, Marc De Moya, Imtiaz Wani, Alain Chichom Mefire, Ken Boffard, Lena Napolitano, Fausto Catena
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a "planned second-look" laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29424447/behavioural-intervention-to-reduce-resistance-in-those-attending-adult-day-care-centers-procendias-study-protocol-for-a-randomized-clinical-trial
#6
Emiliano Rodriguez-Sánchez, Olaya Tamayo-Morales, Jesús González-Sanchez, Sara Mora-Simón, Andrés Losada-Baltar, Jaime Unzueta-Arce, María C Patino-Alonso, Elena De Dios-Rodríguez, Manuel A Gómez-Marcos, Luis García-Ortiz
AIM: This study evaluates the effectiveness of a behavioural intervention program aimed at reducing the reluctance of dependent people to attend Adult Day Care Centres. We hope that reducing resistance will have a positive influence on the mental health of caregivers. BACKGROUND: Care centres offer important relief and rest services for family caregivers. Some caregivers report being affected by behavioural and psychological symptoms of dementia when they prepare dependents for the Care Centres, especially when these have dementia...
February 9, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29420521/los-polifenoles-de-la-fresa-disminuyen-el-estr%C3%A3-s-oxidativo-en-enfermedades-cr%C3%A3-nicas
#7
Cecilia Isabel Oviedo-Solís, Sinthia Cornejo-Manzo, Blanca Olivia Murillo-Ortiz, Michelle Montserrat Guzmán-Barrón, Joel Ramírez-Emiliano
El consumo de dietas hipercalóricas conlleva al aumento de ácidos grasos libres (AGL), citocinas proinflamatorias y producción de especies reactivas de oxígeno y de nitrógeno. Estas alteraciones inducen estrés oxidativo y nitrosativo que daña a los tejidos causando disfunción de los mismos y en consecuencia se pueden desarrollar enfermedades crónicas. Por lo tanto, es importante disminuir el estrés oxidativo y con ello prevenir el desarrollo de estas enfermedades. La fresa es un fruto rico en vitamina C y polifenoles, compuestos con excelentes propiedades antioxidantes, por lo que puede ser una opción para la disminución del estrés oxidativo y por lo tanto, para prevenir el desarrollo de algunas enfermedades...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29420467/her-kinase-inhibition-in-patients-with-her2-and-her3-mutant-cancers
#8
David M Hyman, Sarina A Piha-Paul, Helen Won, Jordi Rodon, Cristina Saura, Geoffrey I Shapiro, Dejan Juric, David I Quinn, Victor Moreno, Bernard Doger, Ingrid A Mayer, Valentina Boni, Emiliano Calvo, Sherene Loi, Albert C Lockhart, Joseph P Erinjeri, Maurizio Scaltriti, Gary A Ulaner, Juber Patel, Jiabin Tang, Hannah Beer, S Duygu Selcuklu, Aphrothiti J Hanrahan, Nancy Bouvier, Myra Melcer, Rajmohan Murali, Alison M Schram, Lillian M Smyth, Komal Jhaveri, Bob T Li, Alexander Drilon, James J Harding, Gopa Iyer, Barry S Taylor, Michael F Berger, Richard E Cutler, Feng Xu, Anna Butturini, Lisa D Eli, Grace Mann, Cynthia Farrell, Alshad S Lalani, Richard P Bryce, Carlos L Arteaga, Funda Meric-Bernstam, José Baselga, David B Solit
Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically uncharacterized. Here we define the biological and therapeutic importance of known oncogenic HER2 and HER3 mutations and variants of unknown biological importance by conducting a multi-histology, genomically selected, 'basket' trial using the pan-HER kinase inhibitor neratinib (SUMMIT; clinicaltrials...
February 8, 2018: Nature
https://www.readbyqxmd.com/read/29420390/specific-adaptations-in-performance-and-muscle-architecture-after-weighted-jump-squat-vs-body-mass-squat-jump-training-in-recreational-soccer-players
#9
Giuseppe Coratella, Marco Beato, Chiara Milanese, Stefano Longo, Eloisa Limonta, Susanna Rampichini, Emiliano Cè, Angela Valentina Bisconti, F Schena, F Esposito
The aim of the present study was to compare the effects of weighted jump squat (WJST) vs body mass squat jump training (BMSJT) on quadriceps muscle architecture, lower-limb lean-mass (LM) and muscle strength, performance in change of direction (COD), sprint and jump in recreational soccer-players. Forty-eight healthy soccer-players participated in an off-season randomized controlled-trial. Before and after an eight-week training intervention, vastus lateralis pennation angle, fascicle length, muscle thickness, LM, squat 1-RM, quadriceps and hamstrings isokinetic peak-torque, agility T-test, 10 and 30m sprint and squat-jump (SJ) were measured...
February 6, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29416049/protective-effect-of-group-b-streptococcus-type-iii-polysaccharide-conjugates-against-maternal-colonization-ascending-infection-and-neonatal-transmission-in-rodent-models
#10
Emiliano Chiarot, Angela Spagnuolo, Silvia Maccari, Eleonora Naimo, Alessandra Acquaviva, Raffaella Cecchi, Bruno Galletti, Monica Fabbrini, Elena Mori, Paolo Ruggiero, Guido Grandi, Maria Rita Fontana, Giuliano Bensi, Immaculada Margarit
Group B Streptococcus (GBS) is a normal inhabitant of recto-vaginal mucosae in up to 30% of healthy women. Colonization is a major risk factor for perinatal infection which can lead to severe complications such as stillbirth and neonatal invasive disease. Intra-partum antibiotic prophylaxis in colonized women is a safe and cost-effective preventive measure against early-onset disease in the first days of life, but has no effect on late-onset manifestations or on early maternal infection. Maternal immunization with capsular polysaccharide-based vaccines shows promise for the prevention of both early-onset and late-onset neonatal infections, although ability to prevent maternal colonization and ascending infection has been less studied...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29409715/hydration-dependent-dynamics-of-water-in-calcium-silicate-hydrate-a-qens-study-by-global-model
#11
Peisi Le, Emiliano Fratini, Sow-Hsin Chen
HYPOTHESIS: In a saturated cement paste, there are three different types of water: the structural water chemically reacted with cement, the constrained water absorbed to the surface of the pores, and the free water in the center of the pores. Each type has different physicochemical state and unique relation to cement porosity. The different water types have different dynamics which can be detected using quasi-elastic neutron scattering (QENS). Since the porosity of a hardened cement paste is impacted strongly by the water to cement ratio (w/c), it should be possible to extract the hydration dependence of the pores by exploiting the dynamical parameters of the confined water...
February 2, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29407156/chlorophyll-a-in-cyclodextrin-supramolecular-complexes-as-a-natural-photosensitizer-for-photodynamic-therapy-pdt-applications
#12
Paola Semeraro, Guglielmina Chimienti, Emiliano Altamura, Paola Fini, Vito Rizzi, Pinalysa Cosma
Chlorophyll a (Chl a), an amphipathic porphyrin, was employed as natural photosensitizer for photodynamic therapy applications. Due to its lacking solubility in water and high tendency to aggregate, Chl a was included into different modified cyclodextrins (CDs) to form stable water-soluble supramolecular complexes. To achieve this aim, 2-Hydroxypropyl-β-cyclodextrin (2-HP-β-CD), 2-Hydroxypropyl-γ-cyclodextrin (2-HP-γ-CD), Heptakis(2,6-di-o-methyl)-β-cyclodextrin (DIMEB) and Heptakis(2,3,6-tri-o-methyl)-β-cyclodextrin (TRIMEB) were used...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29405036/structural-modeling-of-altered-clcn1-conformation-following-a-novel-mutation-in-a-patient-affected-by-autosomal-dominant-myotonia-congenita-thomsen-disease
#13
Rosangela Ferese, Veronica Albano, Mattia Falconi, Federico Iacovelli, Rosa Campopiano, Simona Scala, Anna Maria Griguoli, Anderson Gaglione, Emiliano Giardina, Stefania Zampatti, Marianna Storto, Francesco Fornai, Carmelo D'Alessio, Giuseppe Novelli, Stefano Gambardella
No abstract text is available yet for this article.
December 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29405028/next-generation-sequencing-and-als-known-genes-different-phenotyphes
#14
Rosa Campopiano, Larisa Ryskalin, Emiliano Giardina, Stefania Zampatti, Carla L Busceti, Francesca Biagioni, Rosangela Ferese, Marianna Storto, Stefano Gambardella, Francesco Fornai
Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease clinically characterized by upper and lower motor neuron dysfunction resulting in rapidly progressive paralysis and death from respiratory failure. Most cases appear to be sporadic, but 5-10 % of cases have a family history of the disease, and over the last decade, identification of mutations in about 20 genes predisposing to these disorders has provided the means to better understand their pathogenesis. Next Generation sequencing (NGS) is an advanced high-throughput DNA sequencing technology which have rapidly contributed to an acceleration in the discovery of genetic risk factors for both familial and sporadic neurological and neurodegenerative diseases...
December 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29402309/embryonic-stem-cell-derived-cardiomyocytes-for-the-treatment-of-doxorubicin-induced-cardiomyopathy
#15
Danúbia Silva Dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho, Regina Coeli Dos Santos Goldenberg
BACKGROUND: Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic stem cells (CM-mESCs) in the treatment of Dox-induced cardiomyopathy (DIC) in mice. METHODS: The mouse embryonic stem cell (mESC) line E14TG2A was characterized by karyotype analysis, gene expression using RT-PCR and immunofluorescence. Cells were transduced with luciferase 2 and submitted to cardiac differentiation...
February 5, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29401262/novel-insights-by-4d-flow-imaging-on-aortic-flow-physiology-after-valve-sparing-root-replacement-with-or-without-neosinuses
#16
Nicola Galea, Filippo Piatti, Francesco Sturla, Jonathan W Weinsaft, Christopher Lau, Ilaria Chirichilli, Iacopo Carbone, Emiliano Votta, Carlo Catalano, Ruggero De Paulis, Leonard N Girardi, Alberto Redaelli, Mario Gaudino
OBJECTIVES: This study was undertaken to evaluate the flow dynamics in the aortic root after valve-sparing root replacement with and without neosinuses of Valsalva reconstruction, by exploiting the capability of 4D Flow imaging to measure in vivo blood velocity fields and 3D geometric flow patterns. METHODS: Ten patients who underwent valve-sparing root replacement utilizing grafts with neosinuses or straight tube grafts (5 cases each) were evaluated by 4D Flow imaging at a mean of 46...
February 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29400465/correction-to-connecting-metallic-nanoparticles-by-optical-printing
#17
Julián Gargiulo, Santiago Cerrotta, Emiliano Cortés, Ianina L Violi, Fernando D Stefani
No abstract text is available yet for this article.
February 5, 2018: Nano Letters
https://www.readbyqxmd.com/read/29396431/game-changing-restraint-of-ros-damaged-phenylalanine-upon-tumor-metastasis
#18
Geraldine Gueron, Nicolás Anselmino, Paula Chiarella, Emiliano G Ortiz, Sofia Lage Vickers, Alejandra V Paez, Jimena Giudice, Mario D Contin, Daiana Leonardi, Felipe Jaworski, Verónica Manzano, Ariel Strazza, Daniela R Montagna, Estefania Labanca, Javier Cotignola, Norma D Accorso, Anna Woloszynska-Read, Nora Navone, Roberto P Meiss, Raúl Ruggiero, Elba Vazquez
An abrupt increase in metastatic growth as a consequence of the removal of primary tumors suggests that the concomitant resistance (CR) phenomenon might occur in human cancer. CR occurs in murine tumors and ROS-damaged phenylalanine, meta-tyrosine (m-Tyr), was proposed as the serum anti-tumor factor primarily responsible for CR. Herein, we demonstrate for the first time that CR happens in different experimental human solid tumors (prostate, lung anaplastic, and nasopharyngeal carcinoma). Moreover, m-Tyr was detected in the serum of mice bearing prostate cancer (PCa) xenografts...
February 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29394874/alcoholic-monoterpenes-found-in-essential-oil-of-aromatic-spices-reduce-allergic-inflammation-by-the-modulation-of-inflammatory-cytokines
#19
Lícia T S Pina, Jamylle N S Ferro, Thallita K Rabelo, Marlange A Oliveira, Luciana Scotti, Marcus Tullius Scotti, Cristiani Isabel Bandero Walker, Emiliano O Barreto, Lucindo J Quintans Júnior, Adriana G Guimarães
Allergic inflammation is a response of the body against pathogens by cytokine release and leucocyte recruitment. Recently, there was an increase in morbimortality associated with allergic inflammation, especially asthma. The treatment has many adverse effects, requiring the search for new therapies. Monoterpenes are natural products with anti-inflammatory activity demonstrated in several studies and can be an option to inflammation management. Thus, we investigated the effects of citronellol, α-terpineol and carvacrol on allergic inflammation...
February 2, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29393623/correction-to-accuracy-and-mechanistic-details-of-optical-printing-of-single-au-and-ag-nanoparticles
#20
Julián Gargiulo, Ianina L Violi, Santiago Cerrotta, Lukáš Chvátal, Emiliano Cortés, Eduardo Perassi, Fernando Diaz, Pavel Zemánek, Fernando D Stefani
No abstract text is available yet for this article.
February 2, 2018: ACS Nano
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