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https://www.readbyqxmd.com/read/28650649/decoration-of-chondroitin-polysaccharide-with-threonine-synthesis-conformational-study-and-ice-recrystallization-inhibition-activity
#1
Antonio Laezza, Angela Casillo, Sandro Cosconati, Caroline I Biggs, Antonio Fabozzi, Luigi Paduano, Alfonso Iadonisi, Ettore Novellino, Matthew I Gibson, Antonio Randazzo, Maria Michela Corsaro, Emiliano Bedini
Several threonine (Thr)- and/or alanine (Ala)-rich antifreeze glycoproteins (AFGPs) and polysaccharides act in nature as ice recrystallization inhibitors. Among them, the Thr-decorated capsular polysaccharide (CPS) from the cold-adapted Colwellia psychrerythraea 34H bacterium was recently investigated for its cryoprotectant activity. A semi-synthetic mimic thereof was here prepared from microbial sourced chondroitin through a four step strategy, involving a partial protection of the chondroitin polysaccharide as a key step for gaining an unprecedented quantitative amidation of its glucuronic acid units...
June 26, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28647325/the-processing-of-semantic-relatedness-in-the-brain-evidence-from-associative-and-categorical-false-recognition-effects-following-transcranial-direct-current-stimulation-of-the-left-anterior-temporal-lobe
#2
Emiliano Díez, Carlos J Gómez-Ariza, Antonio M Díez-Álamo, María A Alonso, Angel Fernandez
A dominant view of the role of the anterior temporal lobe (ATL) in semantic memory is that it serves as an integration hub, specialized in the processing of semantic relatedness by way of mechanisms that bind together information from different brain areas to form coherent amodal representations of concepts. Two recent experiments, using brain stimulation techniques along with the Deese-Roediger-McDermott (DRM) paradigm, have found a consistent false memory reduction effect following stimulation of the ATL, pointing to the importance of the ATL in semantic/conceptual processing...
June 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28638339/nutritional-and-pharmacological-strategies-to-regulate-microglial-polarization-in-cognitive-aging-and-alzheimer-s-disease
#3
REVIEW
Emiliano Peña-Altamira, Sabrina Petralla, Francesca Massenzio, Marco Virgili, Maria L Bolognesi, Barbara Monti
The study of microglia, the immune cells of the brain, has experienced a renaissance after the discovery of microglia polarization. In fact, the concept that activated microglia can shift into the M1 pro-inflammatory or M2 neuroprotective phenotypes, depending on brain microenvironment, has completely changed the understanding of microglia in brain aging and neurodegenerative diseases. Microglia polarization is particularly important in aging since an increased inflammatory status of body compartments, including the brain, has been reported in elderly people...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28638147/sensitivity-of-human-pluripotent-stem-cells-to-insulin-precipitation-induced-by-peristaltic-pump-based-medium-circulation-considerations-on-process-development
#4
Diana Massai, Emiliano Bolesani, Diana Robles Diaz, Christina Kropp, Henning Kempf, Caroline Halloin, Ulrich Martin, Tudor Braniste, Giuseppe Isu, Vanessa Harms, Umberto Morbiducci, Gerald Dräger, Robert Zweigerdt
Controlled large-scale production of human pluripotent stem cells (hPSCs) is indispensable for their envisioned clinical translation. Aiming at advanced process development in suspension culture, the sensitivity of hPSC media to continuous peristaltic pump-based circulation, a well-established technology extensively used in hydraulically-driven bioreactors, was investigated. Unexpectedly, conditioning of low protein media (i.e. E8 and TeSR-E8) in a peristaltic pump circuit induced severe viability loss of hPSCs cultured as aggregates in suspension...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28635075/salts-influence-cathechins-and-flavonoids-encapsulation-in-liposomes-a-molecular-dynamics-investigation
#5
Emiliano Laudadio, Giovanna Mobbili, Cristina Minnelli, Luca Massaccesi, Roberta Galeazzi
Cathechins and flavonoids are responsible of numerous health benefits. Two of the most representatives' compounds for their antioxidant and therapeutic effects are Epigallocatechin 3-Gallate (EGCG), from green tea extracts, and morelloflavone (MF), from Garcinia dulcis. Here we explore, by atomistic Molecular Dynamics simulations, how EGCG and MF interact with lipid bilayers and we show the salts' influence on their encapsulation degree in neutral liposomes. As a result, we found out that EGCGs naturally bind to the hydrophilic regions of phospholipids, positioning themselves mostly at the interface between water and lipid phases...
June 21, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28632678/transversus-abdominis-plane-block-as-analgesic-technique-for-postoperative-pain-management-after-cesarean-section-no-more
#6
Pierfrancesco Fusco, Paolo Scimia, Emiliano Petrucci, Stefano Di Carlo, Giuseppe Paladini, Franco Marinangeli
No abstract text is available yet for this article.
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28631525/polyphenol-profile-by-uhplc-ms-ms-anti-glycation-antioxidant-and-cytotoxic-activities-of-several-samples-of-propolis-from-the-northeastern-semi-arid-region-of-brazil
#7
Jadriane de Almeida Xavier, Iara Barros Valentim, Fabiana O S Camatari, Alberto M M de Almeida, Henrique Fonseca Goulart, Jamylle Nunes de Souza Ferro, Emiliano de Oliveira Barreto, Bruno Coelho Cavalcanti, Carla B G Bottoli, Marília Oliveira Fonseca Goulart
CONTEXT: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil - sample A from Ribeira do Pombal and B, from Tucano - were investigated, with new information regarding their biological activities. OBJECTIVE: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. MATERIAL AND METHODS: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH(•), FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28631459/could-the-new-ultrasound-guided-erector-spinae-plane-block-be-a-valid-alternative-to-paraverteral-block-in-chest-chronic-pain-syndromes
#8
Pierfrancesco Fusco, Stefano DI Carlo, Paolo Scimia, Antonio Luciani, Emiliano Petrucci, Franco Marinangeli
No abstract text is available yet for this article.
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28625637/a-randomized-phase-2-evaluation-of-the-chk1-inhibitor-ly2603618-administered-in-combination-with-pemetrexed-and-cisplatin-in-patients-with-advanced-nonsquamous-non-small-cell-lung-cancer
#9
Thomas Wehler, Michael Thomas, Christian Schumann, Joaquim Bosch-Barrera, Nuria Viñolas Segarra, Nicolas J Dickgreber, Klaus Dalhoff, Martin Sebastian, Jesus Corral Jaime, Miriam Alonso, Scott M Hynes, Ji Lin, Karla Hurt, Aimee Bence Lin, Emiliano Calvo, Luis Paz-Ares
This phase 2 portion of a phase 1/2 study examined the efficacy and safety of LY2603618, a selective checkpoint kinase 1 inhibitor, combined with pemetrexed and cisplatin (LY+Pem+Cis) in patients with advanced nonsquamous non-small cell lung cancer (NSCLC). This multicenter, randomized, controlled, open-label study (NCT01139775) enrolled patients with stage IV nonsquamous NSCLC and an Eastern Cooperative Oncology Group performance status ≤1. Patients were randomized (2:1) to LY+Pem+Cis or pemetrexed and cisplatin (Pem+Cis)...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28624661/targeting-human-liver-cancer-cells-with-lactobionic-acid-g-4-pamam-fitc-sorafenib-loaded-dendrimers
#10
Iacobazzi Rosa Maria, Porcelli Letizia, Lopedota Angela Assunta, Laquintana Valentino, Lopalco Antonio, Cutrignelli Annalisa, Altamura Emiliano, Di Fonte Roberta, Azzariti Amalia, Franco Massimo, Denora Nunzio
Reported here is the synthesis and biological evaluation of the asialoglycoprotein receptor (ASGP-R) targeted fourth generation poliamidoamine dendrimer (G(4)-PAMAM) loaded with sorafenib. The ASGP-R targeted dendrimer was obtained by conjugation of Lactobionic acid (La) to the G(4)-PAMAM dendrimer, followed by acetylation (Ac) of the free amino groups in order to reduce the non-specific interactions with the cell membrane. Moreover, by additionally grafting fluorescein (FITC), it was easy to characterize the internalization pathway and the intracellular fate of the targeted dendrimer Ac-La-G(4)-PAMAM-FITC...
June 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28622565/a-shear-induced-network-of-aligned-wormlike-micelles-in-a-sugar-based-molecular-gel-from-gelation-to-biocompatibility-assays
#11
Juliette Fitremann, Barbara Lonetti, Emiliano Fratini, Isabelle Fabing, Bruno Payré, Christelle Boulé, Isabelle Loubinoux, Laurence Vaysse, Luis Oriol
A new low molecular weight hydrogelator with a saccharide (lactobionic) polar head linked by azide-alkyne click chemistry was prepared in three steps. It was obtained in high purity without chromatography, by phase separation and ultrafiltration of the aqueous gel. Gelation was not obtained reproducibly by conventional heating-cooling cycles and instead was obtained by shearing the aqueous solutions, from 2 wt% to 0.25 wt%. This method of preparation favored the formation of a quite unusual network of interconnected large but thin 2D-sheets (7nm-thick) formed by the association side-by-side of long and aligned 7nm diameter wormlike micelles...
June 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28613812/role-of-oxygen-deposition-pressure-in-the-formation-of-ti-defect-states-in-tio2-001-anatase-thin-films
#12
Benoit Gobaut, Pasquale Orgiani, Alessia Sambri, Emiliano di Gennaro, Carmela Aruta, Francesco Borgatti, Valerio Lollobrigida, Denis Céolin, Jean-Pascal Rueff, Regina Ciancio, Chiara Bigi, Pranab Kumar Das, Jun Fujii, Damjan Krizmancic, Piero Torelli, Ivana Vobornik, Giorgio Rossi, Fabio Miletto Granozio, Umberto Scotti di Uccio, Giancarlo Panaccione
We report the study of anatase TiO2(001)-oriented thin films grown by pulsed laser deposition on LaAlO3(001). A combination of in situ and ex situ methods has been used to address both the origin of the Ti(3+)-localized states and their relationship with the structural and electronic properties on the surface and the subsurface. Localized in-gap states are analyzed using resonant X-ray photoelectron spectroscopy and are related to the Ti(3+) electronic configuration, homogeneously distributed over the entire film thickness...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28613248/laser-ablation-for-cancer-past-present-and-future
#13
REVIEW
Emiliano Schena, Paola Saccomandi, Yuman Fong
Laser ablation (LA) is gaining acceptance for the treatment of tumors as an alternative to surgical resection. This paper reviews the use of lasers for ablative and surgical applications. Also reviewed are solutions aimed at improving LA outcomes: hyperthermal treatment planning tools and thermometric techniques during LA, used to guide the surgeon in the choice and adjustment of the optimal laser settings, and the potential use of nanoparticles to allow biologic selectivity of ablative treatments. Promising technical solutions and a better knowledge of laser-tissue interaction should allow LA to be used in a safe and effective manner as a cancer treatment...
June 14, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28599628/tribe-2-a-phase-iii-randomized-open-label-strategy-trial-in-unresectable-metastatic-colorectal-cancer-patients-by-the-gono-group
#14
Chiara Cremolini, Federica Marmorino, Fotios Loupakis, Gianluca Masi, Carlotta Antoniotti, Lisa Salvatore, Marta Schirripa, Luca Boni, Vittorina Zagonel, Sara Lonardi, Giuseppe Aprile, Emiliano Tamburini, Vincenzo Ricci, Monica Ronzoni, Filippo Pietrantonio, Chiara Valsuani, Gianluca Tomasello, Alessandro Passardi, Giacomo Allegrini, Samantha Di Donato, Daniele Santini, Alfredo Falcone
BACKGROUND: Chemotherapy plus bevacizumab is a standard first-line treatment for unresectable metastatic colorectal cancer patients. Different chemotherapy backbones may be chosen, including one to three drugs, based on patients' general conditions and comorbidities, treatments' objectives, and disease characteristics. TRIBE trial demonstrated a significant advantage in terms of progression-free survival and overall survival for FOLFOXIRI plus bevacizumab as compared with FOLFIRI plus bevacizumab...
June 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28596729/detection-and-evaluation-of-spatio-temporal-spike-patterns-in-massively-parallel-spike-train-data-with-spade
#15
Pietro Quaglio, Alper Yegenoglu, Emiliano Torre, Dominik M Endres, Sonja Grün
Repeated, precise sequences of spikes are largely considered a signature of activation of cell assemblies. These repeated sequences are commonly known under the name of spatio-temporal patterns (STPs). STPs are hypothesized to play a role in the communication of information in the computational process operated by the cerebral cortex. A variety of statistical methods for the detection of STPs have been developed and applied to electrophysiological recordings, but such methods scale poorly with the current size of available parallel spike train recordings (more than 100 neurons)...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28580545/polymer-nanoparticles-containing-essential-oils-new-options-for-mosquito-control
#16
Jorge Omar Werdin González, Emiliano Nicolás Jesser, Cristhian Alan Yeguerman, Adriana Alicia Ferrero, Beatriz Fernández Band
Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, two different essential oils (EO) (geranium, Geranium maculatum, and bergamot, Citrus bergamia) loaded polymeric nanoparticle (PN) were elaborated using polyethylene glycol (PEG) and chitosan (Qx) as the polymeric matrix/coating...
June 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28577667/clinical-syntax-score-predicts-outcomes-of-patients-undergoing-coronary-artery-bypass-grafting
#17
Giovanni Melina, Emiliano Angeloni, Simone Refice, Francesco Monti, Roberto Serdoz, Stefano Rosato, Fulvia Seccareccia, Furio Colivicchi, Roberta Serdoz, Francesco Paneni, Riccardo Sinatra
BACKGROUND: The SYNTAX score (SS) is a determinant of outcome in patients undergoing percutaneous coronary intervention. In addition, it has been recently shown that the clinical SYNTAX score (cSS), obtained by adding clinical variables to the SS, improves the predictive power of the resulting risk model. We assessed the hypothesis that the use of the cSS may predict outcomes of patients undergoing coronary artery bypass grafting (CABG). METHODS: We measured the SYNTAX score in 874 patients undergoing isolated first time on-pump CABG...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28573741/patterns-of-morphological-integration-between-parietal-and-temporal-areas-in-the-human-skull
#18
Emiliano Bruner, Ana Sofia Pereira-Pedro, Markus Bastir
Modern humans have evolved bulging parietal areas and large, projecting temporal lobes. Both changes, largely due to a longitudinal expansion of these cranial and cerebral elements, were hypothesized to be the result of brain evolution and cognitive variations. Nonetheless, the independence of these two morphological characters has not been evaluated. Because of structural and functional integration among cranial elements, changes in the position of the temporal poles can be a secondary consequence of parietal bulging and reorientation of the head axis...
June 2, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28572056/effects-of-exercise-on-depressive-behavior-and-striatal-levels-of-norepinephrine-serotonin-and-their-metabolites-in-sleep-deprived-mice
#19
Thiago Medeiros da Costa Daniele, Pedro Felipe Carvalhedo de Bruin, Emiliano Ricardo Vasconcelos Rios, Veralice Meireles Sales de Bruin
Exercise is a promising adjunctive therapy for depressive behavior, sleep/wake abnormalities, cognition and motor dysfunction. Conversely, sleep deprivation impairs mood, cognition and functional performance. The objective of this study is to evaluate the effects of exercise on anxiety and depressive behavior and striatal levels of norepinephrine (NE), serotonin and its metabolites in mice submitted to 6h of total sleep deprivation (6h-TSD) and 72h of Rapid Eye Movement (REM) sleep deprivation (72h-REMSD). Experimental groups were: (1) mice submitted to 6h-TSD by gentle handling; (2) mice submitted to 72h-REMSD by the flower pot method; (3) exercise (treadmill for 8 weeks); (4) exercise followed by 6h-TSD; (5) exercise followed by 72h-REMSD; (6) control (home cage)...
May 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28570912/current-suicidal-ideation-in-treatment-seeking-individuals-in-the-united-kingdom-with-gambling-problems
#20
Silvia Ronzitti, Emiliano Soldini, Neil Smith, Marc N Potenza, Massimo Clerici, Henrietta Bowden-Jones
BACKGROUND: Studies show higher lifetime prevalence of suicidality in individuals with pathological gambling. However, less is known about the relationship between pathological gambling and current suicidal ideation. OBJECTIVES: We investigated socio-demographic, clinical and gambling-related variables associated with suicidality in treatment-seeking individuals. METHODS: Bivariate analyses and logistic regression models were generated on data from 903 individuals to identify measures associated with aspects of suicidality...
May 24, 2017: Addictive Behaviors
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