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https://www.readbyqxmd.com/read/28094990/bridging-the-gap-between-dielectric-nanophotonics-and-the-visible-regime-with-effectively-lossless-gap-antennas
#1
Javier Cambiasso, Gustavo Grinblat, Yi Li, Aliaksandra Rakovich, Emiliano Cortés, Stefan A Maier
We present all-dielectric gallium phosphide (GaP) nanoantennas as an efficient nanophotonic platform for surface-enhanced second harmonic generation (SHG) and fluorescence (SEF), showing negligible losses in the visible range. Employing single GaP nanodisks, we observe an increase of more than three orders of magnitude in the SHG signal in comparison with the bulk. This constitutes an SHG efficiency as large as 0.0002%, which is, to the best of our knowledge, the highest yet achieved value produced by a single nano-object in the optical region...
January 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28077561/micrornas-stimulate-translation-initiation-mediated-by-hcv-like-ireses
#2
Chloé Mengardi, Taran Limousin, Emiliano P Ricci, Ricardo Soto-Rifo, Didier Decimo, Théophile Ohlmann
MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression by recognizing and hybridizing to a specific sequence generally located in the 3' untranslated region (UTR) of targeted mRNAs. miRNA-induced inhibition of translation occurs during the initiation step, most probably at the level of ribosome scanning. In this process, the RNA-induced silencing complex interacts both with PABP and the 43S pre-initiation complex to disrupt scanning of the 40S ribosome. However, in some specific cases, miRNAs can stimulate translation...
January 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28076841/clonal-evolution-in-therapy-related-neoplasms
#3
Emiliano Fabiani, Giulia Falconi, Luana Fianchi, Marianna Criscuolo, Tiziana Ottone, Laura Cicconi, Stefan Hohaus, Simona Sica, Massimiliano Postorino, Antonino Neri, Marta Lionetti, Giuseppe Leone, Francesco Lo-Coco, Maria Teresa Voso
Therapy-related myeloid neoplasms (t-MN) may occur as a late effect of cytotoxic therapy for a primary malignancy or autoimmune diseases in susceptible individuals. We studied the development of somatic mutations in t-MN, using a collection of follow-up samples from 14 patients with a primary hematologic malignancy, who developed a secondary leukemia (13 t-MN and 1 t-acute lymphoblastic leukemia), at a median latency of 73 months (range 18-108) from primary cancer diagnosis.Using Sanger and next generation sequencing (NGS) approaches we identified 8 mutations (IDH1 R132H, ASXL1 Y591*, ASXL1 S689*, ASXL1 R693*, SRSF2 P95H, SF3B1 K700E, SETBP1 G870R and TP53 Y220C) in seven of thirteen t-MN patients (54%), whereas the t-ALL patient had a t(4,11) translocation, resulting in the KMT2A/AFF1 fusion gene...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28065872/posterior-cervical-transfacet-fusion-with-facetal-spacer-for-the-treatment-of-single-level-cervical-radiculopathy-a-randomized-controlled-prospective-study
#4
Jacopo Lenzi, Antonio Nardone, Emiliano Passacantilli, Alessandro Caporlingua, Gennaro Lapadula, Federico Caporlingua
BACKGROUND: single level cervical radiculopathy may be treated conservatively with cervical tractions. Posterior cervical transfacet fusion with a facetal spacer is a viable option. The aim of the present study is to compare posterior cervical transfacet fusion to conservative physical treatment in single level cervical radiculopathy METHODS: 80 patients were randomized in 2 groups. A surgical group where patients were given posterior cervical transfacet fusion and a traction group where patients were treated conservatively with mechanical cervical tractions...
January 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28064079/tacrine-resveratrol-fused-hybrids-as-multi-target-directed-ligands-against-alzheimer-s-disease
#5
Jakub Jeřábek, Elisa Uliassi, Laura Guidotti, Jan Korábečný, Ondřej Soukup, Vendula Sepsova, Martina Hrabinova, Kamil Kuča, Manuela Bartolini, Luis Emiliano Peña-Altamira, Sabrina Petralla, Barbara Monti, Marinella Roberti, Maria Laura Bolognesi
Multi-target drug discovery is one of the most followed approaches in the active central nervous system (CNS) therapeutic area, especially in the search for new drugs against Alzheimer's disease (AD). This is because innovative multi-target-directed ligands (MTDLs) could more adequately address the complexity of this pathological condition. In a continuation of our efforts aimed at a new series of anti-AD MTDLs, we combined the structural features of the cholinesterase inhibitor drug tacrine with that of resveratrol, which is known for its purported antioxidant and anti-neuroinflammatory activities...
December 26, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28061762/the-effectiveness-of-daclatasvir-based-therapy-in-european-patients-with-chronic-hepatitis-c-and-advanced-liver-disease
#6
Jim Young, Nina Weis, Harald Hofer, William Irving, Ola Weiland, Emiliano Giostra, Juan Manuel Pascasio, Lluis Castells, Martin Prieto, Roelien Postema, Cinira Lefevre, David Evans, Heiner C Bucher, Jose Luis Calleja
BACKGROUND: There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatitis C, a life expectancy of less than 12 months and no other treatment options. METHODS: A retrospective multi-country cohort of patients with chronic hepatitis C who received daclatasvir as part of the Named Patient Program in Austria, Denmark, Spain, Sweden, Switzerland and the United Kingdom...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28060735/the-natural-compound-fucoidan-from-new-zealand-undaria-pinnatifida-synergizes-with-the-erbb-inhibitor-lapatinib-enhancing-melanoma-growth-inhibition
#7
Varsha Thakur, Jun Lu, Giuseppe Roscilli, Luigi Aurisicchio, Manuela Cappelletti, Emiliano Pavoni, William Lindsey White, Barbara Bedogni
Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28054621/scientists-in-germany-peru-and-taiwan-to-lose-access-to-elsevier-journals
#8
Quirin Schiermeier, Emiliano Rodríguez Mega
No abstract text is available yet for this article.
December 23, 2016: Nature
https://www.readbyqxmd.com/read/28054512/the-effect-of-reactions-on-the-formation-and-readout-of-the-gradient-of-bicoid
#9
Emiliano Perez Ipiña, Silvina Ponce Dawson
During early development, the establishment of gradients of transcriptional factors determines the patterning of cell fates. The case of Bicoid (Bcd) in <i>Drosophila melanogaster</i> embryos is well documented and studied. There are still controversies as to whether <i> SDD</i> models in which Bcd is <i>Synthesized</i> at one end, then <i>Diffuses</i> and is <i>Degraded</i> can explain the gradient formation within the timescale observed experimentally...
January 5, 2017: Physical Biology
https://www.readbyqxmd.com/read/28050544/influence-of-mononuclear-cell-therapy-on-disc-degeneration-in-rabbits
#10
Rodrigo Caldonazzo Fávaro, André de Oliveira Arruda, Luiz Roberto Gomes Vialle, Emiliano Neves Vialle
OBJECTIVE: The objective of this research was to evaluate the influence of autologous mononuclear stem cells injections on histological changes of collagen in the fibrous annulus of the intervertebral disk after experimental injury. METHODS: 32 New Zealand rabbits were submitted to intervertebral disk puncture, followed by intradiscal injection of mononuclear cells from the iliac crest versus saline injection in the following time periods: two months after the injury (SC2M and SS2M), two weeks (SC2W and SS2W) immediately after injury (SCCP and SSCP), and without inducing degeneration (SCSP and SSSP)...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28043049/quality-changes-in-refrigerated-stored-minced-pork-wrapped-with-plastic-cling-film-and-the-effect-of-glucose-supplementation
#11
Alba Del Blanco, Irma Caro, Emiliano J Quinto, Javier Mateo
Meat spoilage greatly depends on meat composition and storage conditions. Microbial and biochemical changes in minced pork (100-g portions) wrapped with a polyvinyl chloride film during a 4-day refrigerated storage were studied. As glucose is the first substrate used by spoilage bacteria and when it is depleted bacteria could generate undesirable volatiles, the effect of the addition of glucose to minced meat was also studied. Three treatments were used: control (C), without added glucose, and low and high glucose concentration (L and H), 150mg and 750mg of glucose in 100g of meat, respectively...
December 18, 2016: Meat Science
https://www.readbyqxmd.com/read/28035548/peribiliary-gland-dilatation-in-cirrhosis-relationship-with-liver-failure-and-stem-cell-proliferation-markers
#12
Nicolas Goossens, Romain Breguet, Claudio De Vito, Sylvain Terraz, Nathalie Lin-Marq, Emiliano Giostra, Laura Rubbia-Brandt, Laurent Spahr
BACKGROUND AND AIMS: Dilated peribiliary glands (PBG) in patients with cirrhosis are often an incidental finding although their significance and physiopathology remain unclear. We aimed to identify clinical factors associated with dilated PBG and to perform a detailed morphometric assessment of dilated PBG in cirrhotic patients undergoing liver transplantation (LT). METHODS: All consecutive cirrhotic patients undergoing LT at our institution between October 2006 and October 2011 were assessed for inclusion...
December 29, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28032857/heme-oxygenase-1-in-the-forefront-of-a-multi-molecular-network-that-governs-cell-cell-contacts-and-filopodia-induced-zippering-in-prostate-cancer
#13
Alejandra V Paez, Carla Pallavicini, Federico Schuster, Maria Pia Valacco, Jimena Giudice, Emiliano G Ortiz, Nicolás Anselmino, Estefania Labanca, Maria Binaghi, Marcelo Salierno, Marcelo A Martí, Javier H Cotignola, Anna Woloszynska-Read, Luciana Bruno, Valeria Levi, Nora Navone, Elba S Vazquez, Geraldine Gueron
Prostate cancer (PCa) cells display abnormal expression of cytoskeletal proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown that heme oxygenase 1 (HO-1) is implicated in cell morphology regulation in PCa. Here, through a multi 'omics' approach we define the HO-1 interactome in PCa, identifying HO-1 molecular partners associated with the integrity of the cellular cytoskeleton. The bioinformatics screening for these cytoskeletal-related partners reveal that they are highly misregulated in prostate adenocarcinoma compared with normal prostate tissue...
December 29, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/28031779/brain-derived-neurotrophic-factor-plasma-levels-and-premature-cognitive-impairment-dementia-in-type-2-diabetes
#14
Blanca Murillo Ortíz, Joel Ramírez Emiliano, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara
AIM: To assess the relationship of brain-derived neurotrophic factor (BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS: The study included 40 patients with diabetes mellitus type 2 (DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy (HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment. RESULTS: The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment...
December 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/28031257/sexual-pheromone-modulates-the-frequency-of-cytosolic-ca2-bursts-in-saccharomyces-cerevisiae
#15
Natalia Carbó, Nahuel Tarkowski, Emiliano Perez Ipiña, Silvina Ponce Dawson, Pablo S Aguilar
Transient and highly regulated elevations of cytosolic Ca(2+) control a variety of cellular processes. Bulk measurements using radioactive Ca(2+) and the luminescent sensor aequorin have shown that in response to pheromone, budding yeast cells experience a rise of cytosolic Ca(2+) that is mediated by two import systems composed by the Mid1-Cch1-Ecm7 protein complex, and the Fig 1 protein. Although this response has been largely studied, there is no report on Ca(2+) dynamics at the single cell level. Here, using protein calcium indicators we show that both vegetative and pheromone-treated yeast cells exhibit discrete and asynchronous Ca(2+) bursts...
December 28, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28030568/space-use-and-movement-of-a-neotropical-top-predator-the-endangered-jaguar
#16
Ronaldo G Morato, Jared A Stabach, Chris H Fleming, Justin M Calabrese, Rogério C De Paula, Kátia M P M Ferraz, Daniel L Z Kantek, Selma S Miyazaki, Thadeu D C Pereira, Gediendson R Araujo, Agustin Paviolo, Carlos De Angelo, Mario S Di Bitetti, Paula Cruz, Fernando Lima, Laury Cullen, Denis A Sana, Emiliano E Ramalho, Marina M Carvalho, Fábio H S Soares, Barbara Zimbres, Marina X Silva, Marcela D F Moraes, Alexandre Vogliotti, Joares A May, Mario Haberfeld, Lilian Rampim, Leonardo Sartorello, Milton C Ribeiro, Peter Leimgruber
Accurately estimating home range and understanding movement behavior can provide important information on ecological processes. Advances in data collection and analysis have improved our ability to estimate home range and movement parameters, both of which have the potential to impact species conservation. Fitting continuous-time movement model to data and incorporating the autocorrelated kernel density estimator (AKDE), we investigated range residency of forty-four jaguars fit with GPS collars across five biomes in Brazil and Argentina...
2016: PloS One
https://www.readbyqxmd.com/read/28017743/embolization-of-dural-arteriovenous-fistula-of-the-cavernous-sinus-through-percutaneous-ultrasound-guided-puncture-of-the-facial-vein
#17
Andrea M Alexandre, Emiliano Visconti, Emilio Lozupone, Francesco D'Argento, Alessandro Pedicelli
No abstract text is available yet for this article.
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28011399/graphene-oxide-alginate-beads-as-adsorbents-influence-of-the-load-and-the-drying-method-on-their-physicochemical-mechanical-properties-and-adsorptive-performance
#18
Emiliano Platero, Maria Emilia Fernandez, Pablo Ricardo Bonelli, Ana Lea Cukierman
Graphene oxide/alginate beads were prepared from lab-synthesized graphene oxide, varying its content within the beads (0.05, 0.125, and 0.25wt.%). Ethanol-drying and lyophilization were compared as drying methods to obtain suitable adsorbents which were later tested to the removal of a model organic molecule (methylene blue). The morphological and textural properties of all the beads were characterized by scanning electron microscopy and N2 adsorption/desorption isotherms at -196°C, respectively. Limited porosity was obtained for all cases (SBET<60m(2)/g)...
December 11, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28008755/an-exploratory-analysis-of-the-association-between-levels-of-hormones-implied-in-steroid-biosynthesis-and-activity-of-abiraterone-in-patients-with-metastatic-castration-resistant-prostate-cancer
#19
Valentina Bertaglia, Marcello Tucci, Francesca Vignani, Consuelo Buttigliero, Emiliano Aroasio, Alfredo Berruti, Giorgio V Scagliotti, Massimo DI Maio
BACKGROUND: Abiraterone acetate, approved for patients with metastatic castration-resistant prostate cancer (mCRPC), blocks androgen byosinthesis. We aimed to describe changes determined by abiraterone in hormones implied in steroid biosynthesis, exploring association between hormonal levels and drug activity. METHODS: Patients with mCRPC, receiving standard abiraterone + prednisone after docetaxel failure, were studied. We determined serum levels of progesterone, 17OH-progesterone, cortisol, ACTH, DHEA-sulphate, androstenedione, testosterone, sex hormone-binding globulin, aldosterone, plasma renin activity, and cholesterol, baseline and every 12 weeks...
December 22, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28007880/residual-syntax-score-following-coronary-artery-bypass-grafting%C3%A2
#20
Giovanni Melina, Emiliano Angeloni, Simone Refice, Cristian Benegiamo, Andrea Lechiancole, Maria Matteucci, Antonino Roscitano, Roberto Bianchini, Fabio Capuano, Cosimo Comito, Pietro Spitaleri, Euclide Tonelli, Giulio Speciale, Christian Pristipino, Francesco Monti, Roberto Serdoz, Francesco Paneni, Riccardo Sinatra
OBJECTIVES: To quantify residual coronary artery disease measured using the SYNTAX score (SS) and its relation to outcomes after coronary artery bypass grafting (CABG). METHODS: We conducted a retrospective analysis on a consecutive series of 1608 patients [mean age 68 years, standard deviation (SD): 7, F:M, 242:1366] undergoing first-time isolated CABG from 2004 to 2015. The baseline SS was retrospectively determined from preoperative angiograms, and the residual SS (rSS) was measured during assessment of the actual operative report for each patient after CABG...
December 22, 2016: European Journal of Cardio-thoracic Surgery
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