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https://www.readbyqxmd.com/read/29035549/water-as-a-probe-of-colloidal-properties-of-cement
#1
Francesca Ridi, Monica Tonelli, Emiliano Fratini, Sow-Hsin Chen, Piero Baglioni
Cement is produced by mixing mineral phases based on calcium silicates and aluminates with water. The hydration reaction of the mixture leads to a synthetic material with outstanding properties that can be used as a binder for construction applications. Despite the importance of cement in society, for a long time, the chemical reactions involved in its hydration remained poorly understood due to the complexity of hydration processes, nanostructure and transport phenomena. This feature article reviews the recently obtained results using water as "a probe" to detail the essential features in the setting process...
October 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29035173/one-year-in-review-2017-systemic-sclerosis
#2
REVIEW
Simone Barsotti, Cosimo Bruni, Martina Orlandi, Alessandra Della Rossa, Emiliano Marasco, Veronica Codullo, Serena Guiducci
Systemic sclerosis is a rare acquired systemic disease characterised by heterogeneous evolution and outcome. Each year novel insights into the pathogenesis, diagnosis and treatment of this severe disease have been published. We herewith provide our overview of the most significant literature contributions published over the last year.
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29027325/ecological-plant-epigenetics-evidence-from-model-and-non-model-species-and-the-way-forward
#3
Christina L Richards, Conchita Alonso, Claude Becker, Oliver Bossdorf, Etienne Bucher, Maria Colomé-Tatché, Walter Durka, Jan Engelhardt, Bence Gaspar, Andreas Gogol-Döring, Ivo Grosse, Thomas P van Gurp, Katrin Heer, Ilkka Kronholm, Christian Lampei, Vít Latzel, Marie Mirouze, Lars Opgenoorth, Ovidiu Paun, Sonja J Prohaska, Stefan A Rensing, Peter F Stadler, Emiliano Trucchi, Kristian Ullrich, Koen J F Verhoeven
Growing evidence shows that epigenetic mechanisms contribute to complex traits, with implications across many fields of biology. In plant ecology, recent studies have attempted to merge ecological experiments with epigenetic analyses to elucidate the contribution of epigenetics to plant phenotypes, stress responses, adaptation to habitat, and range distributions. While there has been some progress in revealing the role of epigenetics in ecological processes, studies with non-model species have so far been limited to describing broad patterns based on anonymous markers of DNA methylation...
October 12, 2017: Ecology Letters
https://www.readbyqxmd.com/read/29027198/shape-analysis-of-spatial-relationships-between-orbito-ocular-and-endocranial-structures-in-modern-humans-and-fossil-hominids
#4
Ana Sofia Pereira-Pedro, Michael Masters, Emiliano Bruner
The orbits and eyes of modern humans are situated directly below the frontal lobes and anterior to the temporal lobes. Contiguity between these orbital and cerebral elements could generate spatial constraints, and potentially lead to deformation of the eye and reduced visual acuity during development. In this shape analysis we evaluate whether and to what extent covariation exists between ocular morphology and the size and spatial position of the frontal and temporal areas in adult modern humans. Magnetic resonance imaging (MRI) was used to investigate patterns of variation among the brain and eyes, while computed tomography (CT) was used to compare cranial morphology in this anatomical region among modern humans, extinct hominids and chimpanzees...
October 13, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29024818/differential-cortical-contribution-of-syntax-and-semantics-an-fmri-study-on-two-word-phrasal-processing
#5
Marianne Schell, Emiliano Zaccarella, Angela D Friederici
Linguistic expressions consist of sequences of words combined together to form phrases and sentences. The neurocognitive process handling word combination is drawing increasing attention among the neuroscientific community, given that the underlying syntactic and semantic mechanisms of such basic combinations-although essential to the generation of more complex structures-still need to be consistently determined. The current experiment was conducted to disentangle the neural networks supporting syntactic and semantic processing at the level of two-word combinations...
September 20, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28994569/carbon-coated-self-expandable-stents-in-patients-with-atherosclerotic-iliac-artery-disease
#6
Nicola Troisi, Leonardo Ercolini, Emiliano Chisci, Pierfrancesco Frosini, Filippo Turini, Stefano Michelagnoli
BACKGROUND: Aim of this study was to evaluate the safety and effectiveness of carbon-coated self- expandable stents in the revascularization of atherosclerotic iliac artery lesions. METHODS: Between January 2012 and June 2016 54 carbon-coated self-expandable stents (Easy HiFlype and Easy Flype; manufactured by CID S.p.A., a member of Alvimedica Group, Istanbul, Turkey) in 40 patients were implanted in our Center. Early and 2-year outcomes have been evaluated in terms of major morbidity, mortality, primary patency, primary assisted patency, secondary patency, absence of target lesion restenosis (TLR), healing of the lesions/relief of symptoms, and limb salvage...
October 10, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28987780/different-levels-of-visual-perceptual-skills-are-associated-with-specific-modifications-in-functional-connectivity-and-global-efficiency
#7
Sabrina Danti, Giacomo Handjaras, Luca Cecchetti, Helen Beuzeron-Mangina, Pietro Pietrini, Emiliano Ricciardi
The disembedding ability (i.e., the ability to identify a simple masked figure within a complex one) depends on attentional mechanisms, executive functions and working memory. Recent cognitive models ascribed different levels of disembedding task performance to the efficiency of the subtended mental processes engaged during visuo-spatial perception. Here we aimed at assessing whether different levels of the disembedding ability were associated to the functional signatures of neural efficiency, defined as a specific modulation in response magnitude and functional connectivity strength in task-related areas...
October 5, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28987037/hypnosis-and-osteopathic-manipulative-treatment-for-visual-disorders-during-pregnancy-a-case-report
#8
Giancarlo Russo, Alessandro Remonato, Roberto Remonato, Emiliano Zanier
Context • Pregnancy causes physiological alterations to the visual system, particularly in relation to retinal vascularization, with a consequent increase of intraocular pressure, and to the lacrimal fluid, with a consequent ocular dryness, which both can lead to a reduction in visual acuity. Numerous case reports refer to the employment of hypnotic treatment in cases of myopia, but the literature does not report any case of decreased visual acuity postpartum that was treated with hypnosis. Objective • For women with visual disorders that had appeared during pregnancy or were preexisting, the study intended to evaluate the benefits of treatment of the diaphragm by hypnotherapy and osteopathy to modify intracorporeal pressure and restore the women's visual function...
July 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28986522/mammalian-ape1-controls-mirna-processing-and-its-interactome-is-linked-to-cancer-rna-metabolism
#9
Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, Mikiei Tanaka, Chiara D'Ambrosio, Shiheng Zhang, Slobodanka Radovic, Emiliano Dalla, Yari Ciani, Andrea Scaloni, Mengxia Li, Silvano Piazza, Gianluca Tell
Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear. Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism. Through the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and stability via association with the DROSHA-processing complex during genotoxic stress...
October 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28985579/metformin-and-insulin-impact-on-clinical-outcome-in-patients-with-advanced-hepatocellular-carcinoma-receiving-sorafenib-validation-study-and-biological-rationale
#10
Andrea Casadei Gardini, Luca Faloppi, Serena De Matteis, Francesco Giuseppe Foschi, Nicola Silvestris, Francesco Tovoli, Vincenzo Palmieri, Giorgia Marisi, Oronzo Brunetti, Umberto Vespasiani-Gentilucci, Giuseppe Perrone, Martina Valgiusti, Anna Maria Granato, Giorgio Ercolani, Giulia Negrini, Emiliano Tamburini, Giuseppe Aprile, Alessandro Passardi, Daniele Santini, Stefano Cascinu, Giovanni Luca Frassineti, Mario Scartozzi
PURPOSE: In 2015, we published a study on a small series of patients with hepatocellular carcinoma (HCC) treated chronically with metformin for type II diabetes mellitus (DM2) who showed a poorer response to sorafenib. The aim of the present study was to validate the prognostic significance of metformin in HCC patients treated with sorafenib, providing a biological rationale for the mechanism of resistance to sorafenib in patients on chronic metformin therapy, and to clarify the role of sirtuin-3 (SIRT-3), a protein involved in metabolic diseases and acknowledged as a tumour suppressor in HCC, in this resistance...
October 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28984095/the-addition-of-continuous-wound-infusion-of-local-anaesthetics-to-local-infiltration-in-the-management-of-postoperative-pain-and-rehabilitation-after-total-hip-arthroplasty-a-double-blind-randomized-controlled-trial
#11
Pierfrancesco Fusco, Vincenza Cofini, Emiliano Petrucci, Paolo Scimia, Maurizio Fiorenzi, Giuseppe Paladini, Astrid U Behr, Battista Borghi, Stefano Flamini, Renzo Pizzoferrato, Olivo Colafarina, Alexander DI Francesco, Tito Tabacco, Stefano Necozione, Franco Marinangeli
BACKGROUND: Total hip arthroplasty is one of the most common procedures in orthopaedic surgery. We hypothesized that local infiltration of analgesia and continuous wound infusion of anaesthetics in the first 72 h after surgery could provide more effective postoperative analgesia with better rehabilitation. METHODS: A double-blind, randomized, controlled study was conducted with 96 patients who underwent total hip arthroplasty. The patients were randomized to receive either a local infiltration analgesia and continuous wound infusion of anaesthetics or a local infiltration analgesia and continuous wound infusion of saline solution...
October 4, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28980099/prevalence-of-schizophrenia-spectrum-disorders-in-average-iq-adults-with-autism-spectrum-disorders-a-meta-analysis
#12
Jorge Lugo Marín, Montserrat Alviani Rodríguez-Franco, Vinita Mahtani Chugani, María Magán Maganto, Emiliano Díez Villoria, Ricardo Canal Bedia
Since their separation as independent diagnostics, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) have been conceptualized as mutually exclusive disorders. Similarities between both disorders can lead to misdiagnosis, especially when it comes to average-IQ adults who were not identified during childhood. The aim of this review was to examine the occurrence of SSD in average-IQ adults with ASD. Electronic and manual searches identified a total of 278 references, of which 10 were included in a meta-analysis...
October 4, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28978043/gtse1-a-novel-tead4-e2f1-target-gene-involved-in-cell-protrusions-formation-in-triple-negative-breast-cancer-cell-models
#13
Debora Stelitano, Yamila Peche Leticia, Emiliano Dalla, Martin Monte, Silvano Piazza, Claudio Schneider
GTSE1 over-expression has been reported as a potential marker for metastasis in various types of malignancies, including breast cancer. Despite this, the transcriptional regulation of this protein and the causes of its misregulation in tumors remain largely unknown. The aims of this work were to elucidate how GTSE1 is regulated at the transcriptional level and to clarify the mechanism underlying GTSE1-dependent cell functions in triple-negative breast cancer (TNBC). Here, we identified GTSE1 as a novel target gene of the TEAD4 transcription factor, highlighting a role for the YAP and TAZ coactivators in the transcriptional regulation of GTSE1...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967023/grape-pomace-reduced-reperfusion-arrhythmias-in-rats-with-a-high-fat-fructose-diet
#14
Diahann J Perdicaro, Cecilia Rodriguez Lanzi, Ariel R Fontana, Andrea Antoniolli, Patricia Piccoli, Roberto M Miatello, Emiliano R Diez, Marcela A Vazquez Prieto
Metabolic syndrome (MetS) is a risk factor for sudden cardiac death in humans, but animal models are needed for the study of this association. Grape pomace (GP), obtained from the winemaking process, contains phenolic compounds with potential cardioprotective effects. The aim of this study was to evaluate if a high-fat-fructose (HFF) diet facilitates the occurrence of arrhythmias during the reperfusion, and if a GP supplementation could counteract these effects. Wistar rats were fed with control (Ctrl), HFF diet and HFF plus GP (1 g kg(-1) day(-1)) for six weeks...
October 2, 2017: Food & Function
https://www.readbyqxmd.com/read/28963288/adiposity-measures-and-arterial-stiffness-in-primary-care-the-mark-prospective-observational-study
#15
Leticia Gomez-Sanchez, Luis Garcia-Ortiz, Maria C Patino-Alonso, Jose I Recio-Rodriguez, Fernando Rigo, Ruth Martí, Cristina Agudo-Conde, Emiliano Rodriguez-Sanchez, Jose A Maderuelo-Fernandez, Rafel Ramos, Manuel A Gomez-Marcos
BACKGROUND: The cardiovascular risk of obesity is potentially increased by arterial stiffness. OBJECTIVE: To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk. SETTING: Six Spanish health centres. PARTICIPANTS: We enrolled 2354 adults (age range, 35-74 years; mean age, 61.4±7.7 years, 61.9% male). METHODS: This is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28958330/genetically-confirmed-familial-hypercholesterolemia-in-patients-with-acute-coronary-syndrome
#16
Almudena Amor-Salamanca, Sergio Castillo, Emiliano Gonzalez-Vioque, Fernando Dominguez, Lucía Quintana, Carla Lluís-Ganella, Juan Manuel Escudier, Javier Ortega, Enrique Lara-Pezzi, Luis Alonso-Pulpon, Pablo Garcia-Pavia
BACKGROUND: Genetic screening programs in unselected individuals with increased levels of low-density lipoprotein cholesterol (LDL-C) have shown modest results in identifying individuals with familial hypercholesterolemia (FH). OBJECTIVES: This study assessed the prevalence of genetically confirmed FH in patients with acute coronary syndrome (ACS) and compared the diagnostic performance of FH clinical criteria versus FH genetic testing. METHODS: Genetic study of 7 genes (LDLR, APOB, PCSK9, APOE, STAP1, LDLRAP1, and LIPA) associated with FH and 12 common alleles associated with polygenic hypercholesterolemia was performed in 103 patients with ACS, age ≤65 years, and LDL-C levels ≥160 mg/dl...
October 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28949513/how-water-s-properties-are-encoded-in-its-molecular-structure-and-energies
#17
Emiliano Brini, Christopher J Fennell, Marivi Fernandez-Serra, Barbara Hribar-Lee, Miha Lukšič, Ken A Dill
How are water's material properties encoded within the structure of the water molecule? This is pertinent to understanding Earth's living systems, its materials, its geochemistry and geophysics, and a broad spectrum of its industrial chemistry. Water has distinctive liquid and solid properties: It is highly cohesive. It has volumetric anomalies-water's solid (ice) floats on its liquid; pressure can melt the solid rather than freezing the liquid; heating can shrink the liquid. It has more solid phases than other materials...
October 11, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28948018/ultraviolet-light-c-increases-antioxidant-capacity-of-the-strawberry-fragaria-x-ananassa-in-vitro-and-in-high-fat-diet-induced-obese-rats
#18
Cecilia I Oviedo-Solís, Cuauhtémoc Sandoval-Salazar, Edmundo Lozoya-Gloria, Genaro A Maldonado-Aguilera, Herlinda Aguilar-Zavala, Vicente Beltrán-Campos, Victoriano Pérez-Vázquez, Joel Ramírez-Emiliano
Flavonoids and polyphenols from the strawberry and other fruits have been proposed to reduce the oxidative stress produced by the obesity and her complications. Moreover, it has been proposed that irradiation with UV-C to strawberry may increase the antioxidant capacity of this fruit. The aim of the present study was to explore the effects of the UV-C on antioxidant capacity of strawberry in vitro and in vivo. Strawberry slices were irradiated with ultraviolet light-C (UV-C) at 1.2 W/m(2)/16.5 min; then, the power antioxidant was isolated from the nonirradiated and irradiated strawberry slices into an organic phase, which was lyophilized to finally producing a nonirradiated strawberry extract (NSE) and UV-irradiated strawberry extract (UViSE) powder...
September 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28942896/visuo-spatial-orienting-during-active-exploratory-behavior-processing-of-task-related-and-stimulus-related-signals
#19
Emiliano Macaluso, Akitoshi Ogawa
Functional imaging studies have associated dorsal and ventral fronto-parietal regions with the control of visuo-spatial attention. Previous studies demonstrated that the activity of both the dorsal and the ventral attention systems can be modulated by many different factors, related both to the stimuli and the task. However, the vast majority of this work utilized stereotyped paradigms with simple and repeated stimuli. This is at odd with any real life situation that instead involve complex combinations of different types of co-occurring signals, thus raising the question of the ecological significance of the previous findings...
September 5, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28934484/regulation-of-hur-structure-and-function-by-dihydrotanshinone-i
#20
Preet Lal, Linda Cerofolini, Vito Giuseppe D'Agostino, Chiara Zucal, Carmelo Fuccio, Isabelle Bonomo, Erik Dassi, Stefano Giuntini, Danilo Di Maio, Vikalp Vishwakarma, Ranjan Preet, Sha Neisha Williams, Max S Fairlamb, Rachel Munk, Elin Lehrmann, Kotb Abdelmohsen, Saioa R Elezgarai, Claudio Luchinat, Ettore Novellino, Alessandro Quattrone, Emiliano Biasini, Leonardo Manzoni, Myriam Gorospe, Dan A Dixon, Pierfausto Seneci, Luciana Marinelli, Marco Fragai, Alessandro Provenzani
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. Here, we report the structural determinants of the interaction between DHTS and HuR and the impact of DHTS on HuR binding to target mRNAs transcriptome-wide...
September 19, 2017: Nucleic Acids Research
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