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https://www.readbyqxmd.com/read/28811895/long-term-rearrangement-of-retinal-structures-in-a-novel-mutation-of-x-linked-retinoschisis
#1
Stefano Piermarocchi, Stefania Miotto, Davide Colavito, Elda Del Giudice, Alberta Leon, Veronica Maritan, Rita Piermarocchi, Alma Patrizia Tormene
The aim of the present study was to report a novel mutation in the retinoschisin 1 (RS1) gene in a Caucasian family affected by X-linked juvenile retinoschisis (XLRS) and to describe the long-term modification of retinal structure. Two brothers with an early onset maculopathy were diagnosed with XLRS. Fundus photography, fluorescein angiography, spectral domain optical coherence tomography and electroretinogram analyses were performed. Their sister was also examined. All subjects were screened for mutations in the RS1 gene...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28811281/multimorbidity-dementia-and-health-care-in-older-people-a-population-based-cohort-study
#2
Marcello Tonelli, Natasha Wiebe, Sharon Straus, Martin Fortin, Bruce Guthrie, Matthew T James, Scott W Klarenbach, Helen Tam-Tham, Richard Lewanczuk, Braden J Manns, Hude Quan, Paul E Ronksley, Peter Sargious, Brenda Hemmelgarn
BACKGROUND: Little is known about how multimorbidity, dementia and increasing age combine to influence health outcomes or utilization. Our objective was to examine the joint associations between age, dementia and burden of morbidity with mortality and other clinical outcomes. METHODS: We did a retrospective population-based cohort study of all adults aged 65 years and older residing in Alberta, Canada, between 2002 and 2013. We used validated algorithms applied to administrative and laboratory data from the provincial health ministry to assess the presence/absence of dementia and 29 other morbidities, and their associations with mortality (our primary outcome), other clinical outcomes (emergency department visits, all-cause hospital admissions) and a proxy for loss of independent living (discharge to long-term care)...
August 14, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28810259/reliability-reproducibility-and-prognostic-accuracy-of-the-alberta-stroke-program-early-ct-score-on-ct-perfusion-and-non-contrast-ct-in-hyperacute-stroke
#3
Jillian Naylor, Leonid Churilov, Ziyuan Chen, Miriam Koome, Neil Rane, Bruce C V Campbell
BACKGROUND: Alberta Stroke Program Early CT Score (ASPECTS) assesses early ischemic change on non-contrast CT (NCCT). We hypothesised that assessing ASPECTS regions on CT Perfusion (CTP) rather than NCCT would improve inter-rater agreement and prognostic accuracy, particularly in patients presenting early after stroke onset. METHODS: Ischemic stroke patients treated with intravenous alteplase from 2009 to 2014 at our institution were included in this study. Inter-rater agreement and prognostic accuracy of ASPECTS across modalities were analysed by the time between stroke onset and initial NCCT, dichotomized 1st quartile versus quartiles 2-4, referred to as epochs...
August 16, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28806917/study-protocol-pragmatic-randomized-control-trial-of-an-internet-based-intervention-my-tools-4-care-for-family-carers
#4
Wendy Duggleby, Jenny Ploeg, Carrie McAiney, Kathryn Fisher, Jenny Swindle, Tracey Chambers, Sunita Ghosh, Shelley Peacock, Maureen Markle-Reid, Jean Triscott, Allison Williams, Dorothy Forbes, Lori Pollard
BACKGROUND: Family carers of older persons with Alzheimer's' disease and related dementia (ADRD) and multiple chronic conditions (MCC) experience significant, complex, and distressing transitions such as changes to their environment, roles and relationships, physical health, and mental health. An online intervention (My Tools 4 Care) was developed for family carers of persons with ADRD and MCC living at home, with the aim of supporting these carers through transitions and increasing their self-efficacy, hope, and health related quality of life (HRQoL)...
August 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28806554/metal-bioaccumulation-and-biomarkers-of-effects-in-caged-mussels-exposed-in-the-athabasca-oil-sands-area
#5
M Pilote, C André, P Turcotte, F Gagné, C Gagnon
The Athabasca oil sands deposit is the world's largest known reservoir of crude bitumen and the third-largest proven crude oil reserve. Mining activity is known to release contaminants, including metals, and to potentially impact the aquatic environment. The purpose of this study was to determine the impacts of oil sands mining on water quality and metal bioaccumulation in mussels from the Fort McMurray area in northern Alberta, Canada. The study presents two consecutive years of contrasting mussel exposure conditions (low and high flows)...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28803427/unknown-onset-ischemic-strokes-in-patients-last-seen-well-4-5%C3%A2-h-differences-between-wake-up-and-daytime-unwitnessed-strokes
#6
Luuk Dekker, Hajo Hund, Robin Lemmens, Jelis Boiten, Ido van den Wijngaard
Patients with unknown time of stroke onset (UOS) represent around one-third of ischemic stroke patients. These are patients with wake-up stroke (WUS) or daytime-unwitnessed stroke (DUS), often presenting outside the time-window for reperfusion therapy. UOS patients presenting between 4.5 and 12 h after time of last-seen-well were included. Clinical and imaging characteristics were compared between WUS and DUS patients. Good functional outcome was defined as a modified Rankin scale of ≤2 at follow-up. Sixty-one UOS patients were included: 42 WUS and 19 DUS patients...
August 12, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28803139/the-effect-of-age-on-the-manifestations-and-outcomes-of-invasive-pneumococcal-disease-in-adults
#7
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: While a considerable amount is known about the effect of age on the manifestations and outcomes of pneumonia, the same is not true for invasive pneumococcal disease . METHODS: This was a prospective, observational study of all cases (2435) of invasive pneumococcal disease in adults in Northern Alberta from 2000 to 2014. Rates of invasive pneumococcal disease/100,000, sociodemographic variables, clinical characteristics, and invasive pneumococcal disease -related outcomes were compared for the following age groups - 17 to 54, 55 -64, 65 to 74 and 75 years and over...
August 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28799798/abstracts-from-dietetic-research-event-june-8-and-9-2017
#8
(no author information available yet)
St John's, Newfoundland was the host city of the 2017 Dietitians of Canada Annual Conference. Through the support of Dietitians of Canada and CFDR, the 2017 event was both an exciting and informative exchange of research and experience-sharing efforts that inspired attendees. The submissions for this year's Canadian Foundation for Dietetic Research (CFDR) event represented the diversity of dietetic research conducted within Canada. The topics highlighted from this year's abstracts included: Clinical Research; Community-based Nutritional Care; Determinants of Food Choice; Dietary Intake; Dietetic Practice and Education; Food Security; Nutrition and Health Education; Nutritional Assessment and Therapy; Nutrition Attitudes; Nutrition Strategy Development Patient Services; Professional Development; Vulnerable Groups and their Nutritional Needs; and, Wellness and Public Health...
September 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/28799050/environmental-building-policy-by-the-use-of-microalgae-and-decreasing-of-risks-for-canadian-oil-sand-sector-development
#9
Armen B Avagyan
Environmental building recommendations aimed towards new environmental policies and management-changing decisions which as example demonstrated in consideration of the problems of Canadian oil sands operators. For the implementation of the circular economic strategy, we use an in-depth analysis of reported environmental after-consequence on all stages of the production process. The study addressed the promotion of innovative solutions for greenhouse gas emission, waste mitigation, and risk of falling in oil prices for operators of oil sands with creating market opportunities...
August 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28799035/effect-of-heat-stress-on-protein-utilization-and-nutrient-transporters-in-meat-type-chickens
#10
Walid S Habashy, Marie C Milfort, Alberta L Fuller, Youssef A Attia, Romdhane Rekaya, Samuel E Aggrey
The aim of this study was to investigate the effect of heat stress (HS) on digestibility of protein and fat and the expression of nutrient transporters in broilers. Forty-eight male Cobb500 chicks were used in this study. At day 14, birds were randomly divided into two groups and kept under either constant normal temperature (25 °C) or high temperature (35 °C) in individual cages. Five birds per treatment at 1 and 12 days post-treatment were euthanized, and Pectoralis major (P. major) and ileum were sampled for gene expression analysis...
August 10, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28798267/pretreatment-predictors-of-malignant-evolution-in-patients-with-ischemic-stroke-undergoing-mechanical-thrombectomy
#11
Alessandro Davoli, Caterina Motta, Giacomo Koch, Marina Diomedi, Simone Napolitano, Angela Giordano, Marta Panella, Daniele Morosetti, Sebastiano Fabiano, Roberto Floris, Roberto Gandini, Fabrizio Sallustio
BACKGROUND: Few data exist on malignant middle cerebral artery infarction (MMI) among patients with acute ischemic stroke (AIS) after endovascular treatment (ET). Numerous predictors of MMI evolution have been proposed, but a comprehensive research of patients undergoing ET has never been performed. Our purpose was to find a practical model to determine robust predictors of MMI in patients undergoing ET. METHODS: Patients from a prospective single-center database with AIS secondary to large intracranial vessel occlusion of the anterior circulation, treated with ET, were retrospectively analyzed...
August 10, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28793946/training-primary-care-providers-in-the-use-of-motivational-interviewing-for-youth-behavior-change
#12
Monique K Vallabhan, Alberta S Kong, Elizabeth Yakes Jimenez, Linda C Summers, Conni J DeBlieck, Sarah W Feldstein Ewing
BACKGROUND AND PURPOSE: Adolescent obesity is a global epidemic. Motivational interviewing (MI) is a promising strategy to address adolescent obesity risk behaviors. However, primary care providers (PCPs) tend to express discomfort with learning and adopting MI practices and with addressing patient weight issues. PCP proficiency in using MI to discuss body mass index, health screening results, and nutrition and physical activity behaviors after receiving training and coaching from an MI expert and practicing the technique was evaluated...
August 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28793890/network-analysis-of-inter-organizational-relationships-and-policy-use-among-active-living-organizations-in-alberta-canada
#13
Christina C Loitz, Jodie A Stearns, Shawn N Fraser, Kate Storey, John C Spence
BACKGROUND: Coordinated partnerships and collaborations can optimize the efficiency and effectiveness of service and program delivery in organizational networks. However, the extent to which organizations are working together to promote physical activity, and use physical activity policies in Canada, is unknown. This project sought to provide a snapshot of the funding, coordination and partnership relationships among provincial active living organizations (ALOs) in Alberta, Canada. Additionally, the awareness, and use of the provincial policy and national strategy by the organizations was examined...
August 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28783816/association-of-dissemination-of-an-educational-communication-tool-with-docusate-administration
#14
Darren Pasay, Micheal Guirguis, Rhonda Shkrobot, Jeremy Slobodan, Lauren Bresee
Importance: A clear message and call to action can affect the use of a medication with limited efficacy. Objectives: To assess the association of the dissemination of an educational document about the lack of efficacy of docusate with docusate administration and whether changing docusate administration was associated with a change in administration of comparable laxatives. Design, Setting, and Participants: In this quasi-experimental, pre-post study of all acute care and continuing care facilities serviced by Alberta Health Services in Alberta, Canada, an interrupted time series analysis was performed to examine the association of an educational communication tool with docusate administration from June 1, 2014, through May 31, 2016...
August 7, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28783797/nitrous-oxide-emitted-from-soil-receiving-anaerobically-digested-solid-cattle-manure
#15
Ben W Thomas, Xiying Hao
Limited information is available about soil nitrous oxide (NO) fluxes, NO emission factors (EFs), and yield-scaled NO emissions for biogas residues used to fertilize crops in semiarid regions. To address this knowledge gap, a 4-yr field experiment was conducted in a semiarid climate to determine growing season NO fluxes from soil receiving (i) anaerobically digested solid beef cattle manure (digestate), (ii) separated solids from the digestate (separated solids), and (iii) undigested solid beef cattle manure (cattle manure) applied to target one and two times the recommended rates (200 and 400 kg total N ha) for barley ( L...
July 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28782304/primary-treatment-for-oropharyngeal-squamous-cell-carcinoma-in-alberta-canada-a-population-based-study
#16
Amy J Hobbs, Nigel T Brockton, T Wayne Matthews, Shamir P Chandarana, Pinaki Bose, Kelly Guggisberg, Gordon H Fick, Joseph C Dort
BACKGROUND: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is increasing and has better survival than non-HPV related oropharyngeal SCC. This study compared surgical to nonsurgical treatments and demographic, clinical, and survival differences in patients with oropharyngeal SCC, stratified by p16 status. METHODS: We assembled a cohort of adult patients with oropharyngeal SCC diagnosed between 2000 and 2008 in Alberta...
August 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28781847/management-of-common-variable-immunodeficiency-by-subcutaneous-igg-self-administration-during-pregnancy-a-case-report
#17
Carolina Marasco, Alberta Venturelli, Luigia Rao, Angelo Vacca, Maria Rosaria Carratù
Patients with common variable immunodeficiency are prone to infections, and this poses a particular challenge during pregnancy, when the requirement for immunoglobulin (Ig) replacement therapy is even more demanding so as to achieve an effective protection also of the fetus. This case report highlights the benefits observed with subcutaneous IgG self-administration in the management of common variable immunodeficiency (CVID) during pregnancy, in terms of efficacy and safety.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28781051/an-exceptionally-preserved-three-dimensional-armored-dinosaur-reveals-insights-into-coloration-and-cretaceous-predator-prey-dynamics
#18
Caleb M Brown, Donald M Henderson, Jakob Vinther, Ian Fletcher, Ainara Sistiaga, Jorsua Herrera, Roger E Summons
Predator-prey dynamics are an important evolutionary driver of escalating predation mode and efficiency, and commensurate responses of prey [1-3]. Among these strategies, camouflage is important for visual concealment, with countershading the most universally observed [4-6]. Extant terrestrial herbivores free of significant predation pressure, due to large size or isolation, do not exhibit countershading. Modern predator-prey dynamics may not be directly applicable to those of the Mesozoic due to the dominance of very large, visually oriented theropod dinosaurs [7]...
July 31, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28780314/a-high-definition-video-teaching-module-for-thyroidectomy-surgery
#19
Amr F Hamour, Adrian I Mendez, Jeffrey R Harris, Vincent L Biron, Hadi Seikaly, David W J Côté
OBJECTIVE: With the changing landscape of postgraduate surgical education to competency-based curricula, there emerges a need for alternative forms of training. Video teaching modules have been shown to be effective tools in surgical education, complementing traditional postgraduate curricula. There is a lack of validated modules described in the literature, specifically for teaching thyroidectomy. The primary objective of this study was to develop and validate a high definition video-based teaching module instructing thyroidectomy surgery to Otolaryngology-Head and Neck Surgery trainees...
August 2, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28780061/comparative-histories-of-polycyclic-aromatic-compound-accumulation-in-lake-sediments-near-petroleum-operations-in-western-canada
#20
Joshua R Thienpont, Cyndy M Desjardins, Linda E Kimpe, Jennifer B Korosi, Steven V Kokelj, Michael J Palmer, Derek C G Muir, Jane L Kirk, John P Smol, Jules M Blais
We examined the historical deposition of polycyclic aromatic compounds (PACs) recorded in radiometrically-dated lake sediment cores from a small, conventional oil and gas operation in the southern Northwest Territories (Cameron Hills), and placed these results in the context of previously published work from three other important regions of western Canada: (1) the Athabasca oil sands region in Alberta; (2) Cold Lake, Alberta; and (3) the Mackenzie Delta, NT. Sediment PAC records from the Cameron Hills showed no clear changes in either source or concentrations coincident with the timing of development in these regions...
August 3, 2017: Environmental Pollution
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