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https://www.readbyqxmd.com/read/28542601/the-epidemiology-of-staphylococcus-aureus-carriage-in-patients-attending-inner-city-sexually-transmitted-infections-and-community-clinics-in-calgary-canada
#1
Alejandra Ugarte Torres, Angel Chu, Ron Read, Judy MacDonald, Daniel Gregson, Thomas Louie, Johanna Delongchamp, Linda Ward, Joann McClure, Kunyan Zhang, John Conly
BACKGROUND: Although the nares represent the most common carriage site for traditional hospital-associated strains of Staphylococcus aureus (SA), the predominant site of carriage of SA in the community is less certain. METHODS: We conducted a cross-sectional study in 285 patients attending sexually transmitted diseases and inner-city clinics to evaluate the prevalence, body site colonisation and risk factors associated with carriage of methicillin susceptible SA (MSSA)...
2017: PloS One
https://www.readbyqxmd.com/read/28531149/changes-in-objectively-determined-walkability-and-physical-activity-in-adults-a-quasi-longitudinal-residential-relocation-study
#2
Gavin R McCormack, Lindsay McLaren, Grazia Salvo, Anita Blackstaffe
Causal evidence for the built environment's role in supporting physical activity is needed to inform land use and transportation policies. This quasi-longitudinal residential relocation study compared within-person changes in self-reported transportation walking, transportation cycling, and overall physical activity during the past 12 months among adults who did and did not move to a different neighbourhood. In 2014, a random sample of adults from 12 neighbourhoods (Calgary, AB, Canada) with varying urban form and socioeconomic status provided complete self-administered questionnaire data (n = 915)...
May 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28511683/acute-coronary-syndrome-patients-admitted-to-a-cardiology-vs-non-cardiology-service-variations-in-treatment-outcome
#3
Deirdre E O'Neill, Danielle A Southern, Colleen M Norris, Blair J O'Neill, Helen J Curran, Michelle M Graham
BACKGROUND: Specialized cardiology services have contributed to reduced mortality in acute coronary syndromes (ACS).  We sought to evaluate the outcomes of ACS patients admitted to non-cardiology services in Southern Alberta. METHODS: Retrospective chart review performed on all troponin-positive patients in the Calgary Health Region identified those diagnosed with ACS by their attending team. Patients admitted to non-cardiology and cardiology services were compared, using linked data from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) registry and the Strategic Clinical Network for Cardiovascular Health and Stroke...
May 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28506972/career-and-research-outcomes-of-the-physician-scientist-training-program-at-the-university-of-calgary-a-retrospective-cohort-study
#4
Jason T Bau, Alexandra D Frolkis, Nabeela Nathoo, Bryan G Yipp, Morley D Hollenberg, Paul L Beck
BACKGROUND: Physician-scientists are integral to medical research, with medical programs throughout Canada invested in training hybrid physician-scientists. Few data exist as to whether these programs are generating the diversity, gender equity and numbers of trainees essential for the future of medical research and teaching. We aimed to identify factors that contribute to research productivity, diversity and retention of individuals as physician-scientists. METHODS: We completed a retrospective cohort study, for the period 1973 to 2015, of the University of Calgary Leaders in Medicine Program in Calgary, Alberta...
May 15, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28503978/comparison-of-depression-symptoms-between-primary-depression-and-secondary-to-schizophrenia-depression
#5
Twana Rahim, Roshe Rashid
OBJECTIVES: This study exclusively aimed to clinically assess which symptom pattern discriminates primary depression from depression-secondary to-schizophrenia. METHODS: A total of 98 patients with primary depression and 71 patients with secondary-to-schizophrenia depression were assessed for identifying the clinical phenomena of depression. Diagnosis of schizophrenia was confirmed by Mini International Neuropsychiatric Interview. Each participant was, however, assessed by Patient Health Questionnaire-9 as well as Calgary Depression Scale for Schizophrenia (CDSS) for possible concurrent depressive symptoms...
May 15, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28487577/nasal-swab-results-for-methicillin-resistant-staphylococcus-aureus-and-associated-infections
#6
Josée Rioux, Jenny Edwards, Lauren Bresee, Adrian Abu-Ulba, Stephen Yu, Deonne Dersch-Mills, Ben Wilson
BACKGROUND: Nasal-swab screening for methicillin-resistant Staphylococcus aureus (MRSA) has a quicker turnaround time than other bacterial culture methods, with results available within 24 h. Although MRSA nasal-swab screening is not intended to guide antimicrobial therapy, this method may give clinicians additional information for earlier tailoring of empiric antimicrobial agents. OBJECTIVE: To describe the diagnostic characteristics of nasal-swab screening in predicting MRSA infections in hospitalized patients receiving empiric treatment with IV vancomycin...
March 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28477398/individual-training-at-the-undergraduate-level-to-promote-competence-in-breaking-bad-news-in-oncology
#7
Alexandre Berney, Valérie Carrard, Marianne Schmid Mast, Raphael Bonvin, Friedrich Stiefel, Céline Bourquin
OBJECTIVE: Training medical students in breaking bad news (BBN) in oncology may be key to improve patient care in an area where many physicians tend to be uncomfortable. Given the lack of evidence in the literature, this study aimed to assess empirically the impact of two teaching strategies to prepare students for the task of BBN in oncology: one-to-one simulated patient (SP) training with individual feedback (intervention group) vs. small-group SP training with collective feedback (comparison group)...
May 5, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28468262/scalability-issues-for-remote-sensing-infrastructure-a-case-study
#8
Yang Liu, Sean Picard, Carey Williamson
For the past decade, a team of University of Calgary researchers has operated a large "sensor Web" to collect, analyze, and share scientific data from remote measurement instruments across northern Canada. This sensor Web receives real-time data streams from over a thousand Internet-connected sensors, with a particular emphasis on environmental data (e.g., space weather, auroral phenomena, atmospheric imaging). Through research collaborations, we had the opportunity to evaluate the performance and scalability of their remote sensing infrastructure...
April 29, 2017: Sensors
https://www.readbyqxmd.com/read/28446575/evaluation-of-strepb-select-chromagar-and-the-fast-track-diagnostics-group-b-streptococcus-gbs-real-time-polymerase-chain-reaction-assay-compared-to-routine-culture-for-detection-of-gbs-during-antepartum-screening
#9
Deirdre L Church, Heather Baxter, Tracie Lloyd, Oscar Larios, Daniel B Gregson
Life-threatening infection in neonates due to Group B Streptococcus (GBS) is preventable by screening near-term pregnant women and treatment at delivery. 295 vaginal-rectal swabs were collected from women attending antepartum clinics in Calgary. GBS colonization was detected by the standard culture method (Strep B Carrot broth subbed to blood agar with a neomycin disk), and compared to recovery using Strep Group B Broth (Dalynn Biologicals) subbed to StrepB Select chromagar (CA) (Bio-Rad Laboratories), and the Fast Track Diagnostics GBS real-time PCR (qPCR) assay (Phoenix Airmid Biomedical Corp...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28441250/a-comparison-of-survival-outcomes-in-advanced-serous-ovarian-cancer-patients-treated-with-primary-debulking-surgery-versus-neoadjuvant-chemotherapy
#10
Taymaa May, Robyn Comeau, Ping Sun, Joanne Kotsopoulos, Steven A Narod, Barry Rosen, Prafull Ghatage
OBJECTIVE: The management of women with advanced-stage serous ovarian cancer includes a combination of surgery and chemotherapy. The choice of treatment with primary debulking surgery or neoadjuvant chemotherapy varies by institution. The objective of this study was to report 5-year survival outcomes for ovarian cancer patients treated at a single institution with primary debulking surgery or neoadjuvant chemotherapy. METHODS: This study included a retrospective chart review of 303 patients with stage IIIC or IV serous ovarian carcinoma diagnosed in Calgary, Canada...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28418844/loss-of-tumour-specific-atm-protein-expression-is-an-independent-prognostic-factor-in-early-resected-nsclc
#11
Lars F Petersen, Alexander C Klimowicz, Shannon Otsuka, Anifat A Elegbede, Stephanie K Petrillo, Tyler Williamson, Chris T Williamson, Mie Konno, Susan P Lees-Miller, Desiree Hao, Don Morris, Anthony M Magliocco, D Gwyn Bebb
Ataxia-telangiectasia mutated (ATM) is critical in maintaining genomic integrity. In response to DNA double-strand breaks, ATM phosphorylates downstream proteins involved in cell-cycle checkpoint arrest, DNA repair, and apoptosis. Here we investigate the frequency, and influence of ATM deficiency on outcome, in early-resected non-small cell lung cancer (NSCLC). Tissue microarrays, containing 165 formalin-fixed, paraffin-embedded resected NSCLC tumours from patients diagnosed at the Tom Baker Cancer Centre, Calgary, Canada, between 2003 and 2006, were analyzed for ATM expression using quantitative fluorescence immunohistochemistry...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416501/protocol-for-a-placebo-controlled-within-participants-crossover-trial-evaluating-the-efficacy-of-intranasal-oxytocin-to-improve-pain-and-function-among-women-with-chronic-pelvic-musculoskeletal-pain
#12
Joshua A Rash, Kirsti Toivonen, Magali Robert, Maryam Nasr-Esfahani, John F Jarrell, Tavis S Campbell
INTRODUCTION: This protocol presents the rationale and design for a trial evaluating the efficacy of intranasal oxytocin in improving pain and function among women with chronic pelvic musculoskeletal pain. Oxytocin is a neuropeptide traditionally recognised for involvement in labour, delivery and lactation. Novel evidence suggests that oxytocin decreases pain sensitivity in humans. While oxytocin administration has been reported to lower pain sensitivity among patients experiencing chronic back pain, headache, constipation and colon pain, no research has evaluated the association between intranasal oxytocin and chronic pelvic musculoskeletal pain...
April 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28416295/depressive-symptoms-in-schizophrenia-and-dopamine-and-serotonin-gene-polymorphisms
#13
Vjekoslav Peitl, Mario Štefanović, Dalibor Karlović
Although depressive symptoms seem to be frequent in schizophrenia they have received significantly less attention than other symptom domains. As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. Other objectives of this study were to closely examine schizophrenia symptom domains by performing factor analysis of the two most used instruments in this setting (Positive and negative syndrome scale - PANSS and Calgary depression rating scale - CDSS) and to examine the influence of investigated gene polymorphisms on the schizophrenia symptom domains, focusing on depressive scores...
April 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28414583/improved-depressive-symptoms-in-adults-with-schizophrenia-during-a-smoking-cessation-attempt-with-varenicline-and-behavioral-therapy
#14
Corinne Cather, Susanne Hoeppner, Gladys Pachas, Sarah Pratt, Eric Achtyes, Kristina M Cieslak, A Eden Evins
OBJECTIVE: Smoking prevalence rates are elevated in individuals with schizophrenia spectrum disorders (SSD) compared with the general population, with attendant disproportionate smoking-related morbidity and mortality. Pharmacotherapies that improve abstinence rates in this population are underutilized, partly due to concerns about neuropsychiatric safety, particularly for those with comorbid depression or prior suicide attempt. Prospective assessment of the psychiatric safety profile of varenicline in those with SSD is needed...
April 17, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28404475/exploring-the-short-term-impact-of-community-water-fluoridation-cessation-on-children-s-dental-caries-a-natural-experiment-in-alberta-canada
#15
L McLaren, S Patterson, S Thawer, P Faris, D McNeil, M L Potestio, L Shwart
OBJECTIVES: Dental caries (tooth decay) is common and can be serious. Dental caries is preventable, and community water fluoridation is one means of prevention. There is limited current research on the implications of fluoridation cessation for children's dental caries. Our objective was to explore the short-term impact of community water fluoridation cessation on children's dental caries, by examining change in caries experience in population-based samples of schoolchildren in two Canadian cities, one that discontinued community water fluoridation and one that retained it...
February 7, 2017: Public Health
https://www.readbyqxmd.com/read/28401142/comprehensive-survey-of-household-radon-gas-levels-and-risk-factors-in-southern-alberta
#16
Fintan K T Stanley, Siavash Zarezadeh, Colin D Dumais, Karin Dumais, Renata MacQueen, Fiona Clement, Aaron A Goodarzi
BACKGROUND: The inhalation of naturally occurring radon (222Rn) gas from indoor air exposes lung tissue to α-particle bombardment, a highly mutagenic form of ionizing radiation that damages DNA and increases the lifetime risk of lung cancer. We analyzed household radon concentrations and risk factors in southern Alberta, including Calgary, the third-largest Canadian metropolis. METHODS: A total of 2382 residential homes (2018 in Calgary and 364 in surrounding townships) from an area encompassing 82% of the southern Alberta population were tested for radon, per Health Canada guidelines, for at least 90 days (median 103 d) between 2013 and 2016...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28389911/the-effects-of-integrated-nursing-education-on-quality-of-life-and-health-related-outcomes-among-obstructive-sleep-apnea-patients-receiving-continuous-positive-airway-pressure-therapy
#17
Shui-Tao Hu, Chung-Chieh Yu, Chieh-Yu Liu, Lee-Ing Tsao
PURPOSE: This study sought to examine the effects of a nursing education program on quality of life and sleep disturbance among obstructive sleep apnea (OSA) patients receiving continuous positive airway pressure (CPAP) therapy. METHODS: This study was a randomized controlled trial with an intervention group consisting of a nursing education program. The intervention group received the instruction of the CPAP nursing education program, and the control group received routine care...
April 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28389889/nicotine-dependence-is-associated-with-depression-and-childhood-trauma-in-smokers-with-schizophrenia-results-from-the-face-sz-dataset
#18
Romain Rey, Thierry D'Amato, Laurent Boyer, Lore Brunel, Bruno Aouizerate, Fabrice Berna, Delphine Capdevielle, Isabelle Chereau, Gabrielle Chesnoy-Servanin, Hélène Denizot, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Franck Gabayet, Christophe Lancon, Jasmina Mallet, David Misdrahi, Christine Passerieux, Aurélie Schandrin, Franck Schürhoff, Mathieu Urbach, Pierre Vidailhet, Pierre-Michel Llorca, Guillaume Fond
In a perspective of personalized care for smoking cessation, a better clinical characterization of smokers with schizophrenia (SZ) is needed. The objective of this study was to determine the clinical characteristics of SZ smokers with severe nicotine (NIC) dependence. 240 stabilized community-dwelling SZ smokers (mean age = 31.9 years, 80.4% male gender) were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and assessed with validated scales. Severe NIC dependence was defined by a Fagerstrom questionnaire score ≥ 7...
April 7, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28360244/evaluation-of-an-alternative-care-provider-clinic-for-severe-sleep-disordered-breathing-a-study-protocol-for-a-randomised-controlled-trial
#19
Ada Ip-Buting, Jenny Kelly, Maria J Santana, Erika D Penz, W Ward Flemons, Willis H Tsai, Kristin L Fraser, Patrick J Hanly, Sachin R Pendharkar
INTRODUCTION: Despite the high prevalence of sleep-disordered breathing (SDB) and the significant health consequences associated with untreated disease, access to diagnosis and treatment remains a challenge. Even patients with severe SDB (severe obstructive sleep apnoea or hypoventilation), who are at particularly high risk of adverse health effects, are subject to long delays. Previous research has demonstrated that, within a sleep clinic, management by alternative care providers (ACPs) is effective for patients with milder forms of SDB...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28351063/from-communication-skills-to-skillful-communication-a-longitudinal-integrated-curriculum-for-critical-care-medicine-fellows
#20
Amanda L Roze des Ordons, Christopher J Doig, Philippe Couillard, Jason Lord
PROBLEM: Communication with patients and families in critical care medicine (CCM) can be complex and challenging. A longitudinal curricular model integrating multiple techniques within classroom and clinical milieus may facilitate skillful communication across diverse settings. APPROACH: In 2014-2015, the authors developed and implemented a curriculum for CCM fellows at the Cumming School of Medicine, University of Calgary, to promote the longitudinal development of skillful communication...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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