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https://www.readbyqxmd.com/read/29439722/tomatidine-and-analog-fc04-100-possess-bactericidal-activities-against-listeria-bacillus-and-staphylococcus-spp
#1
Isabelle Guay, Simon Boulanger, Charles Isabelle, Eric Brouillette, Félix Chagnon, Kamal Bouarab, Eric Marsault, François Malouin
BACKGROUND: Tomatidine (TO) is a plant steroidal alkaloid that possesses an antibacterial activity against the small colony variants (SCVs) of Staphylococcus aureus. We report here the spectrum of activity of TO against other species of the Bacillales and the improved antibacterial activity of a chemically-modified TO derivative (FC04-100) against Listeria monocytogenes and antibiotic multi-resistant S. aureus (MRSA), two notoriously difficult-to-kill microorganisms. METHODS: Bacillus and Listeria SCVs were isolated using a gentamicin selection pressure...
February 13, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29438295/patient-centered-communication
#2
Cynthia A Naughton
As the population ages, morbidity and mortality associated with chronic disease will increase. Some patient-centered improvements have been made in health care services, but optimal health has not been fully realized. Only when pharmacists have a holistic understanding of an individual patient, including their experience of illness and medication, can they effectively assess appropriateness, safety, efficacy, and adherence to medications and develop realistic treatment plans. When patients are involved in their care, they are better able to manage complex chronic conditions by understanding and adhering to their plan of care...
February 13, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29421173/effects-of-chlorpromazine-on-sleep-quality-clinical-and-emotional-measures-among-patients-with-schizophrenia
#3
Qingli Meng, Rongqin Li, Feng Hou, Qiulan Zhang
OBJECTIVES: The present study was aimed to examine the effects of chlorpromazine on sleep quality, clinical and emotional measures in people suffering from schizophrenia. PATIENTS AND METHODS: Twenty-five patients with schizophrenia or schizoaffective disorder were enrolled in this study. Our study included a one-week running-in no-treatment period and two-month experimental period. Patients received chlorpromazine during the experimental period. The baseline and treatment outcome were recorded...
February 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29417623/serum-levels-of-interleukin-6-in-schizophrenic-patients-during-treatment-augmentation-with-sarcosine-results-of-the-pulsar-study
#4
Dominik Strzelecki, Małgorzata Urban-Kowalczyk, Adam Wysokiński
OBJECTIVE: Augmentation of sarcosine, a natural inhibitor of the glycine transporter type I, normalizes glutamatergic neurotransmission, having beneficial impact on primary negative symptoms in schizophrenia and may also influence immune system and interleukin 6 (IL-6) levels. AIM: Finding a relationship between initial IL-6 serum concentrations or its changes and severity of symptoms as a result of sarcosine addition to stable antipsychotic treatment. METHOD: Fifity-eight individuals with schizophrenia with predominantly negative symptoms completed a 6-month randomized, double-blind placebo-controlled prospective study...
February 7, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29415769/incidence-of-acute-lymphocytic-leukemia-in-calgary-alberta-canada-a-retrospective-cohort-study
#5
Rayven Snodgrass, Leonard T Nguyen, Maggie Guo, Marcus Vaska, Christopher Naugler, Fariborz Rashid-Kolvear
OBJECTIVE: Acute lymphocytic leukemia (ALL) is a rare malignant neoplasm that develops from abnormal lymphoid stem cells. ALL incidence is highest among children and declines towards adolescence. There is limited data on the epidemiology of ALL, especially in Canada. This retrospective cohort study used patient data from the Calgary Laboratory Services Cancer Cytogenetics Laboratory to report the incidence rate of ALL in Calgary, Alberta, Canada. New cases of ALL were identified for the 5-year period of January 1, 2011 until December 31, 2015...
February 7, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29415564/plate-alone-versus-plate-and-lag-screw-for-lapidus-arthrodesis-a-biomechanical-comparison-of-compression
#6
Peter Kameel Garas, Steven Thomas DiSegna, Abhay R Patel
BACKGROUND: Arthrodesis of the first tarsal metatarsal joint can be accomplished in many ways. The compressive force attained between various constructs remains unclear. This study compares compression achieved through a locking/compression Lapidus plate both with and without the addition of a lag screw. METHODS: A dorsal medial Lapidus/locking compression plate (Total Compression Plate System, OrthoPro, Salt Lake City, UT, now Wright Medical) was applied to one cadaveric limb, while the same plate with the addition of a 4...
February 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29402096/collaborative-and-participatory-approaches-to-building-community-capacity-for-palliative-and-end-of-life-care
#7
Martin LaBrie
People living in rural and smaller urban areas near Calgary experience difficulty accessing palliative care services which are concentrated in metropolitan areas. The Cumming School of Medicine, Alberta Health Services and community hospice palliative care societies in two rural communities have been working to develop a partnership that incorporates local health system resources and community initiatives in supporting individuals and families living with progressive, life-limiting illnesses. This presentation will provide an understanding of how academic institutions and health services can collaborate with community members to enhance capacity for end of life care, and enrich communities in the process...
January 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29393575/where-is-in-2017-the-evo-in-evo-devo-evolutionary-developmental-biology
#8
Rui Diogo
After the inaugural Pan-American-Evo-Devo meeting (2015, Berkeley), I showed how major concerns about evo-devo (Evolutionary Developmental Biology) research were demonstrated by a simple, non-biased quantitative analysis of the titles/abstracts of that meeting's talks. Here, I apply the same methodology to the titles/abstracts of the recent Pan-American-Evo-Devo meeting (2017, Calgary). The aim is to evaluate if the concerns raised by me in that paper and by other authors have been addressed and/or if there are other types of differences between the two meetings that may reflect trends within the field of evo-devo...
February 2, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29390164/the-effect-of-melatonin-on-antifungal-susceptibility-in-planktonic-and-biofilm-forms-of-candida-strains-isolated-from-clinical-samples
#9
Özge Kilinçel, Emel Çaliskan, Idris Sahin, Cihadiye Elif Öztürk, Nida Kiliç, Sükrü Öksüz
In recent years, the significant increase in the isolation of antifungal resistant Candida species in presence of biofilm, have made it necessary to develop alternative agents for the treatment of these infections. In this study, the effect of antifungal susceptibility of melatonin were investigated in planktonic and biofilm forms of Candida strains isolated from the clinical samples sent to our laboratory. Biofilm formation was determined by modified microplate method. In order to determine antifungal susceptibility in biofilm-forming strains, MIC was determined by broth microdilution method in planktonic form, and MBEC values by Calgary biofilm method in biofilm form...
January 29, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29363165/lower-bone-density-impaired-microarchitecture-and-strength-predict-future-fragility-fracture-in-postmenopausal-women-5-year-follow-up-of-the-calgary-camos-cohort
#10
Lauren A Burt, Sarah L Manske, David A Hanley, Steven K Boyd
The aim of this prospective study was to use high-resolution peripheral quantitative computed tomography (HR-pQCT) to determine if baseline skeletal parameters can predict incident fragility fracture in women and, secondly, to establish if women that fracture lose bone at a faster rate than those who do not fracture. Women older than 60 years who experienced a fragility fracture during the 5-year follow-up period (incident fracture group, n = 22) were compared with those who did not experience a fragility fracture during the study (n = 127)...
January 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29362215/burns-from-illegal-cannabis-oil-manufacturing-a-case-series
#11
Sarthak Sinha, Kyle Ricord, Patricia Harasym, Jeff A Biernaskie, Duncan Nickerson, Vincent A Gabriel
BACKGROUND: The increasing consideration of cannabis legalization in Canada and the United States has motivated physicians to assess its prospective impact on the health care system. Health care providers in the burns community are concerned about injuries sustained as a result of the illegal manufacturing of cannabis oil because it involves highly flammable reagents. METHODS: We report a retrospective case series of patients with cannabis oil burns (identified by evidence of combustion during cannabis oil manufacturing) treated from April 2012 to March 2014 at the Foothills Medical Centre in Calgary, Alberta, Canada...
January 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29353151/the-association-between-recreational-physical-activity-sedentary-time-and-colorectal-polyps-in-a-population-screened-for-colorectal-cancer
#12
Darren R Brenner, Eileen Shaw, Demetra H Yannitsos, Matthew T Warkentin, Nigel T Brockton, S Elizabeth McGregor, Susanna Town, Robert J Hilsden
PURPOSE: Regular recreational moderate to vigorous physical activity (rMVPA) has been previously associated with a reduced risk of colorectal cancer (CRC), however, few studies have examined the association of rMVPA with colorectal polyps, the pre-malignant precursor lesions. The objective of this study was to examine the associations between physical activity and sitting time and polyps at the time of screening. METHODS: We conducted a cross-sectional study of 2496 individuals undergoing screening-related colonoscopy in Calgary, Alberta, Canada...
January 17, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29352021/proportion-of-women-presenters-at-medical-grand-rounds-at-major-academic-centres-in-canada-a-retrospective-observational-study
#13
Danielle Buell, Brenda R Hemmelgarn, Sharon E Straus
OBJECTIVE: To assess the proportion of women who presented research or medical grand rounds at five major academic hospitals in Canada. DESIGN: A cross-sectional study. SETTING: Five major university-affiliated hospitals in Toronto and Calgary. RESULTS: Overall, at all sites and types of academic rounds, there were an average of 17% fewer women presenting than men (P<0.001). There were an average of 32% and 21% more men presenting at the city-wide grand rounds in cities A and B, respectively (P<0...
January 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/29346698/procedural-knowledge-and-skills-of-residents-entering-canadian-family-medicine-programs-in-alberta
#14
Juan Antonio Garcia-Rodriguez, James A Dickinson, Grace Perez, David Ross, Lilian Au, Shelley Ross, Oksana Babenko, Ian Johnston
BACKGROUND AND OBJECTIVES: Incoming family medicine (FM) residents start residency with different levels of procedural training. Understanding their baseline skill level is necessary to plan the educational experiences and teaching methods that will provide the desired knowledge, skills, and attitudes related to performing medical procedures. METHODS: A survey of 69 procedures based on the core list issued by the College of Family Physicians of Canada was administered to incoming residents in Alberta (Calgary and Edmonton FM programs)...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29336090/microsphere-assemblies-via-phosphonate-monoester-coordination-chemistry
#15
Kamila J Bladek, Margaret E Reid, Hirotomo Nishihara, Farid Akhtar, Benjamin S Gelfand, George K H Shimizu
By complexing a bent phosphonate monoester ligand with cobalt(II), coupled with in situ ester hydrolysis, coordination microspheres (CALS=CALgary Sphere) are formed whereas the use of the phosphonic acid directly resulted in a sheet-like structure. Manipulation of the synthetic conditions gave spheres with different sizes, mechanical stabilities, and porosities. Time-dependent studies determined that the sphere formation likely occurred through the formation of a Co2+ and ligand chain that propagates in three dimensions through different sets of interactions...
January 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334657/relationship-of-obsessive-compulsive-symptoms-to-clinical-variables-and-cognitive-functions-in-individuals-at-ultra-high-risk-for-psychosis
#16
Ahmet Zihni Soyata, Selin Akışık, Damla İnhanlı, Handan Noyan, Alp Üçok
Few studies have investigated the relationship between obsessive-compulsive symptoms (OCS) and clinical variables, and cognition in individuals at ultra high-risk (UHR) for psychosis. The aim of this study was to evaluate the frequency of OCS and their relationship with clinical variables and cognitive functions in individuals at UHR. Eighty-four individuals at UHR for psychosis were administered the Brief Psychiatric Rating Scale, the Yale-Brown Obsession Compulsion Symptom Check List and, the Calgary Depression Scale for Schizophrenia...
January 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29330780/safety-in-mixed-martial-arts-a-7-year-review-of-cancelled-mma-bouts-in-calgary-alberta-during-the-pre-bout-medical-examination-period
#17
Gwynn Curran-Sills
BACKGROUND: Presently, there is no literature that examines the reasons for the cancellation of amateur or professional mixed martial arts (MMA) bouts. The purpose of this study was to review the circumstances that lead to the cancellation of MMA bouts by Calgary ringside physicians during the pre-bout examination period and to identify any emerging patterns that may guide the regulatoin of this sport. METHODS: The case-series  was constructed from the Calgary Combative Sports Commission pre-bout examination records and the medical records submitted by each athlete from January 2010 to December 2016...
January 12, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29311263/an-interview-with-cliff-tabin
#18
Aidan Maartens
Cliff Tabin is George Jacob and Jacqueline Hazel Leder Professor and Chairman of the Department of Genetics at Harvard Medical School. His lab aims to understand the genetic control of morphogenesis during embryonic development and its change over evolutionary time. We met Cliff at the Pan-American Society for Evolutionary Developmental Biology's second biennial meeting, held in Calgary in August 2017, and heard about how he got into development, how a long-standing interest in the limb has been complemented by ventures into new models and why he thinks we are in a golden age for evo-devo...
January 8, 2018: Development
https://www.readbyqxmd.com/read/29310636/sociodemographic-correlates-of-urine-culture-test-utilization-in-calgary-alberta
#19
Thomas P Griener, Christopher Naugler, Wilson W Chan, Deirdre L Church
BACKGROUND: Many clinical practice guidelines encourage diagnosis and empiric treatment of lower urinary tract infection without laboratory investigation; however, urine culture testing remains one of the largest volume tests in the clinical microbiology laboratory. In this study, we sought to determine if there were specific patient groups to which increased testing was directed. To do so, we combined laboratory data on testing rates with Census Canada sociodemographic data. METHODS: Urine culture testing data was obtained from the Calgary Laboratory Services information system for 2011...
January 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29305544/evaluation-of-simplexa%C3%A2-group-a-strep-direct-kit-compared-to-hologic%C3%A2-group-a-streptococcal-direct-assay-for-detection-of-group-a-streptococcus-gas-in-throat-swabs
#20
Deirdre L Church, Tracie Lloyd, Oscar Larios, Daniel B Gregson
Diagnosis of bacterial pharyngitis is confirmed by detection of Group A Streptococcus (GAS) in patient throat samples. Testing of throat samples has historically relied on culture but new molecular methods allow much faster test turnaround time (i.e., same day vs. 48-72h for culture). Our laboratory uses the Hologic® GAS Direct (GASD) assay for screening more than 125,000 throat samples per annum. Simplexa™ GAS Direct is a new real-time PCR (qPCR) assay that does not require initial DNA extraction. Performance of Simplexa qPCR was compared to GASD...
January 5, 2018: Journal of Clinical Microbiology
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