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https://www.readbyqxmd.com/read/28647947/continuous-glucose-monitoring-in-pediatrics-the-gap-between-potential-benefits-and-the-reality-of-utility
#1
Regina L Taddeo, Joanne T Moser, Pantea P Minnock
Continuous Glucose Monitoring (CGM) is rapidly becoming a standard of care in the management of Type 1 diabetes (T1D). Today's devices are nearly as accurate as home glucose meters. They provide glucose data every 5 minutes, alert to high and low blood glucose levels, and allow for remote monitoring of a user's glucose data and patterns. Use of CGM has many benefits including support for tighter glycemic control without increasing the risk for hypoglycemia. There is however emerging evidence of some negative aspects associated with using CGM, which may result in decreased utilization of the device as well as a decline in quality of life, especially in the pediatric population...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28647945/the-emerging-adult-with-diabetes-transitioning-from-pediatric-to-adult-care
#2
Jodi Krall, Ingrid Libman, Linda Siminerio
Transfer from pediatric to adult health care is a significant life event for youth with chronic medical conditions. Unfortunately, youth may not be well prepared to navigate the shift in health care services, increasing their risk for loss to follow up and poor health outcomes. This review explores transition in care through the lens of type 1 diabetes, highlighting current practices and guidelines and offering recommendations for future consideration. Limited evidence suggests that transition programs that focus on strategies to prepare youth developmentally and equip the health care system appropriately have positive impact on the hand off of care, and health outcomes...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28640379/comparative-and-correlative-assessments-of-cytokine-complement-and-antibody-patterns-in-pediatric-type-1-diabetes
#3
M Abdel-Latif, A A Abdel-Moneim, M H El-Hefnawy, R G Khalil
One of the most widespread and effective environmental factors is the infection with enteroviruses (EVs) which accelerate β - cell destruction in type 1 diabetes (T1D). This study represented a comparison between diabetic EV(+) and EV- children as well as correlation analysis between autoantibodies, T1D markers, cytokines, complement activation products and anti- coxsackievirus (CV) IgG. EV RNA was detected in Egyptian children with T1D (26.2%) and healthy controls (0%). Detection of anti - CV IgG in T1D - EV(+) resulted in 64% positivity...
June 22, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28639064/whole-lipid-profile-and-not-only-hdl-cholesterol-is-impaired-in-children-with-coexisting-type-1-diabetes-and-untreated-celiac-disease
#4
Silvana Salardi, Giulio Maltoni, Stefano Zucchini, Dario Iafusco, Angela Zanfardino, Santino Confetto, Sonia Toni, Maximiliano Zioutas, Marco Marigliano, Vittoria Cauvin, Roberto Franceschi, Ivana Rabbone, Barbara Predieri, Riccardo Schiaffini, Alessandro Salvatoni
AIMS: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes...
June 21, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28618748/evaluation-of-polyneuropathy-and-associated-risk-factors-in-children-with-type-1-diabetes-mellitus
#5
Hande Türkyilmaz, Orkide Güzel, Selvinaz Edizer, Aycan Ünalp
BACKGROUND/AIM: Diabetes mellitus (DM) is one of the most common metabolic diseases seen in the world today. Diabetic neuropathy (DN) is a chronic complication of the disease that is rarely reported in children, since it has a relatively longer latency period. Our main objective in this study is to determine the incidence rate of DN in pediatric DM patients and assess the risk factors associated with DN. MATERIALS AND METHODS: Data from 111 patients from January 2011 to May 2014 were reviewed in a retrospective manner...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28617187/retrospective-analysis-of-continuous-glucose-monitoring-data-with-the-surveillance-error-grid-supports-nonadjunctive-dosing-decisions
#6
John B Welsh, Tomas Walker, David Price
OBJECTIVE: The objective was to assess clinical risks of inaccurate continuous glucose monitoring (CGM) system readings as estimated by the surveillance error grid (SEG). METHODS: Values from Dexcom G4 Platinum system with an advanced algorithm (Software 505) were plotted on the SEG with temporally matched reference venous (YSI) values collected during clinic visits on days 1, 4, and 7 of sensor wear. Data from a pediatric study (N = 79, age [mean ± SD] 12.2 ± 4...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28615013/short-term-poor-glycemic-control-and-retinal-microvascular-changes-in-pediatric-type-1-diabetes-patients-in-singapore-a-pilot-study
#7
Ling-Jun Li, Ecosse Lamoureux, Tien Yin Wong, Ngee Lek
BACKGROUND: Poor glycemic control in Type 1 Diabetes (T1D) patients is strongly associated with an increased risk of diabetes-related microvascular complications later in life, but it is unclear whether short period of poor glycemic control in children with T1D can cause evident microvascular morphological changes long before any pathological manifestation. Our study aimed to investigate the longitudinal association between poor glycemic control and subsequent changes in retinal microvasculature, in a pilot study of 55 pediatric T1D patients from Singapore after a one-year follow-up...
June 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28606575/good-adherence-to-the-mediterranean-diet-reduces-the-risk-for-nash-and-diabetes-in-pediatric-patients-with-obesity-the-results-of-an-italian-study
#8
Claudia Della Corte, Antonella Mosca, Andrea Vania, Arianna Alterio, Salvatore Iasevoli, Valerio Nobili
OBJECTIVE: In the last decade, it was demonstrated that the Mediterranean diet (MD) represents an ideal diet for all age groups and has an important role in the prevention of metabolic and cardiovascular diseases, as well as nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to analyze the association between adherence to the MD and NAFLD, with laboratory and histologic evaluation, in a group of children and adolescents with obesity. METHODS: We enrolled 243 patients with obesity referred to our department from March 2014 to November 2015...
July 2017: Nutrition
https://www.readbyqxmd.com/read/28604760/developing-a-neonatal-acute-kidney-injury-research-definition-a-report-from-the-niddk-neonatal-aki-workshop
#9
Michael Zappitelli, Namasivayam Ambalavanan, David J Askenazi, Marva M Moxey-Mims, Paul L Kimmel, Robert A Star, Carolyn L Abitbol, Patrick D Brophy, Guillermo Hidalgo, Mina Hanna, Catherine M Morgan, Tonse N K Raju, Patricio Ray, Zayhara Reyes-Bou, Amani Roushdi, Stuart L Goldstein
Normal developmental changes during postnatal life hinder the development of an AKI definition and advancement of neonatal AKI research. This report summarizes the expert discussion at a National Institute of Diabetes and Digestive and Kidney Diseases sponsored neonatal AKI workshop, on knowledge gaps in defining neonatal AKI. The most important knowledge gaps and neonatal AKI definition research recommendations were agreed upon and defined. Several challenges were identified in defining neonatal AKI using serum creatinine (SCr) and urine output criteria applied in adults and children...
June 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28604759/markers-of-maternal-and-infant-metabolism-are-associated-with-ventricular-dysfunction-in-infants-of-obese-women-with-type-2-diabetes
#10
W Todd Cade, Philip T Levy, Rachel A Tinius, Mehgna D Patel, Swati Choudhry, Mark R Holland, Gautam K Singh, Alison G Cahill
BACKGROUND: To test the hypothesis that infants born to obese women with pregestational type 2 diabetes mellitus (IBDM) have ventricular dysfunction at one month that is associated with markers of maternal lipid and glucose metabolism. METHODS: In a prospective observational study of IBDM (OB+DM, n=25), echocardiography measures of septal, left (LV) and right ventricular (RV) function and structure were compared at one month of age to infants born to OB mothers without DM (OB, n=24), and non-OB without DM (Lean, n=23)...
June 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28598798/level-of-internet-use-among-greek-adolescents-with-type-1-diabetes
#11
Katerina Daniilidou, Panagiota Triantafyllou, Maria Resta, Meropi Dimitriadou, Athanasios Christoforidis
Background Compulsive Internet use has emerged as a contemporary addictive behavior. Our aim was to investigate the reasons for Greek adolescents with type 1 diabetes mellitus (T1DM) and their families to use the Internet and additionally to investigate the level of Internet use and its associations to demographic, socio-economic parameters and glycemic control. Methods Patients with T1DM, aged >12 years and their parents were recruited during their regular visits to the Pediatric Diabetes Clinic. A similar group of healthy children, age- and sex-matched served as a control group...
June 9, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28598410/pediatric-non-alcoholic-fatty-liver-disease
#12
REVIEW
Haley Bush, Pegah Golabi, Zobair M Younossi
Abstract: With the increase in the prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) has become among the leading causes of chronic liver disease in the pediatric age group. Once believed to be a "two-hit process", it is now clear that the actual pathophysiology of NAFLD is complex and involves multiple pathways. Moreover, NAFLD is not always benign, and patients with non-alcoholic steatohepatitis (NASH) are at increased risk of developing advanced stages of liver disease. It has also been shown that NAFLD is not only a liver disease, but is also associated with multiple extrahepatic manifestations, including cardiovascular diseases, type 2 diabetes, and low bone mineral density...
June 9, 2017: Children
https://www.readbyqxmd.com/read/28597949/primary-islet-autoantibody-at-initial-seroconversion-and-autoantibodies-at-diagnosis-of-type-1-diabetes-as-markers-of-disease-heterogeneity
#13
Jorma Ilonen, Johanna Lempainen, Anna Hammais, Antti-Pekka Laine, Taina Härkönen, Jorma Toppari, Riitta Veijola, Mikael Knip
OBJECTIVE: The relationship between patterns of islet autoantibodies at diagnosis and specificity of the first islet autoantibody at the initiation of autoimmunity was analyzed with the aim of identifying patterns informative of the primary autoantibodies. METHODS: Information about a single first autoantibody at seroconversion and autoantibody data at diagnosis were available for 128 children participating in the follow-up cohort of the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study...
June 9, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28592005/-type-2-diabetes-in-the-child-and-adolescent-consensus-in-china
#14
(no author information available yet)
No abstract text is available yet for this article.
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28590880/development-and-validation-of-a-measure-assessing-child-diabetes-behavior-the-diabetes-behavior-checklist
#15
Aditi Lohan, Alina Morawska, Amy E Mitchell
Previous research in pediatric diabetes management has focused on general child behavior, which is linked with treatment adherence and health outcomes in children with type 1 diabetes. Little is known about child diabetes behavior problems specifically. The current study aimed to develop and validate a measure of diabetes-specific child behavior problems, and parents' confidence in managing these behaviors. Participants were a community sample of 186 parents of children aged 2-10 years with type 1 diabetes, recruited via online parenting forums and advertisements placed in school and childcare newsletters throughout Australia...
June 7, 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/28585878/practical-considerations-on-the-use-of-continuous-glucose-monitoring-in-pediatrics-and-older-adults-and-nonadjunctive-use
#16
Gregory P Forlenza, Nicholas B Argento, Lori M Laffel
Clinical use of continuous glucose monitoring (CGM) devices has grown over the past 15 years from a niche concept to becoming standard of care for patients with type 1 diabetes (T1D). With the December 2016 Food and Drug Administration approval for diabetes treatment decisions directly from CGM values (nonadjunctive use) without finger-stick confirmation, the uptake and scope of CGM use will likely further expand. With this expansion, it is important to consider the role and impact of CGM technology in specific settings and high-risk populations, such as the young and the elderly...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28575100/prevalence-of-microalbuminuria-and-its-associated-cardiometabolic-risk-factors-in-korean-youth-data-from-the-korea-national-health-and-nutrition-examination-survey
#17
Heeyeon Cho, Jae Hyun Kim
BACKGROUND: Microalbuminuria is a known early predictive factor for renal and cardiovascular diseases, not only for patients with diabetes mellitus or hypertension but also in the general population. However, the prevalence and risk factors associated with microalbuminuria in Korean youth are unknown. OBJECTIVES: The aims of this study are to evaluate the prevalence of microalbuminuria and the association between microalbuminuria and obesity or cardiometabolic risk factors in Korean children and adolescents without diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28573535/long-term-outcome-of-bariatric-surgery-in-morbidly-obese-adolescents-a-systematic-review-and-meta-analysis-of-950-patients-with-a-minimum-of-3%C3%A2-years-follow-up
#18
Saeed Shoar, Habibollah Mahmoudzadeh, Mohammad Naderan, Shahram Bagheri-Hariri, Catherine Wong, Ahmad Shahabeddin Parizi, Nasrin Shoar
BACKGROUND: Obesity in pediatric and adolescent population has reached a universal pandemic. This study aimed to summarize the literature on the longest available outcome of bariatric surgery in morbidly obese adolescents. METHODS: A systematic review was conducted to pool available data on the longest available (>3 years) weight loss and comorbidity resolution outcome in adolescent bariatric surgery. RESULTS: A total of 14 studies reporting the result of bariatric surgery after 3 years in 950 morbidly obese adolescents were included...
June 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28565750/myocardial-fibrosis-in-congenital-and-pediatric-heart-disease
#19
Jing Tian, Xinjiang An, Ling Niu
Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying cause of fibrotic heart disease. There are four different types of cardiac fibrosis, including, reactive interstitial fibrosis, replacement fibrosis, infiltrative interstitial fibrosis and endomyocardial fibrosis...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28556755/effects-of-exercise-training-alone-on-depot-specific-body-fat-stores-in-youth-review-of-recent-literature
#20
YoonMyung Kim
The prevalence of childhood obesity has increased at an alarming rate. The increased obesity rate in pediatrics parallels the increased risks for developing metabolic abnormalities such as insulin resistance, type 2 diabetes (T2DM), and non-alcoholic fatty liver disease (NAFLD). In particular, the strong relationship between obesity and such health consequences are well explained by the excessive accumulation of depot-specific body adiposity such as visceral adipose tissue (VAT), intrahepatic lipid content, intermuscular AT (IMAT), and/or intramyocellular lipid (IMCL) content...
May 30, 2017: Pediatric Exercise Science
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