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Diabetes pediatric

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https://www.readbyqxmd.com/read/29652667/glycated-hemoglobin-a1c-as-a-screening-test-for-detecting-type-2-diabetes-mellitus-in-obese-children-and-adolescents
#1
Jong Seo Yoon, Cheol Hwan So, Hae Sang Lee, Jin Soon Hwang
BACKGROUND: The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far. METHODS: A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obese children and adolescents aged 4-17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results. RESULTS: A glycated hemoglobin (HbA1c) level of 6...
April 13, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29643888/spectrum-of-complications-of-severe-dka-in-children-in-pediatric-intensive-care-unit
#2
Qalab Abbas, Saba Arbab, Anwar Ul Haque, Khadija Nuzhat Humayun
Objectives: To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods: Retrospective review of the medical records of all children admitted with the diagnosis of severe DKA in Pediatric Intensive Care Unit (PICU) of the Aga Khan University Hospital, from January 2010 to December 2015 was done. Data was collected on a structured proforma and descriptive statistics were applied. Results: Total 37 children were admitted with complicated DKA (1...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29627577/role-of-neopterin-as-a-biochemical-marker-for-peripheral-neuropathy-in-pediatric-patients-with-type-1-diabetes-relation-to-nerve-conduction-studies
#3
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Rana Ahmed El-Hilaly, Fatma Salama Ahmed
BACKGROUND: Neopterin, a marker of inflammation and cellular immune response, is elevated in conditions of T-cell or macrophages activation. Diabetic peripheral neuropathy (DPN) is associated with inflammatory/immune processes and therefore, we hypothesized that neopterin could be used as a marker of neuropathy in type 1 diabetes mellitus (T1DM). AIM: To measure neopterin levels in children and adolescents with T1DM and assess its possible relation to DPN and nerve conduction studies (NCS)...
April 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29626585/the-better-diabetes-diagnosis-bdd-study-a-review-of-a-nationwide-prospective-cohort-study-in-sweden
#4
REVIEW
M Persson, C Becker, H Elding Larsson, Å Lernmark, G Forsander, S A Ivarsson, J Ludvigsson, U Samuelsson, C Marcus, A Carlsson
The incidence of type 1 diabetes (T1D) in Sweden is one of the highest in the world. However, the possibility of other types of diabetes must also be considered. In addition, individuals with T1D constitute a heterogeneous group. A precise classification of diabetes is a prerequisite for optimal outcome. For precise classification, knowledge on the distribution of genetic factors, biochemical markers and clinical features in individuals with new onset of diabetes is needed. The Better Diabetes Diagnosis (BDD), is a nationwide study in Sweden with the primary aim to facilitate a more precise classification and diagnosis of diabetes in order to enable the most adequate treatment for each patient...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29626282/development-and-validation-of-the-pediatric-diabetes-routines-questionnaire-for-adolescents
#5
Jessica S Pierce, Sara S Jordan, Randolph C Arnau
This study describes the development and psychometric evaluation of an adolescent self-report version of the Pediatric Diabetes Routines Questionnaire (PDRQ:A), a measure of diabetes-specific routines for youth with type 1 diabetes, and further validation of the parent-version (PDRQ:P) in an adolescent sample. Participants included 120 parent-adolescent dyads (ages 12-17) and an additional 24 parents who completed measures of diabetes-specific adolescent routines, general adolescent routines, diabetes self-care, and family support of youth diabetes care...
April 6, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29623593/efficacy-and-safety-of-rapid-acting-insulin-analogs-in-special-populations-with-type-1-diabetes-or-gestational-diabetes-systematic-review-and-meta-analysis
#6
REVIEW
Kirsten Nørgaard, Nithya Sukumar, Snorri B Rafnsson, Ponnusamy Saravanan
INTRODUCTION: To assess the efficacy and safety of three available rapid-acting insulin analogs (insulins lispro, aspart and glulisine, respectively) in pregnant women, children/adolescents and people using continuous subcutaneous insulin infusion (CSII) with type 1 diabetes. METHODS: PubMed, EMBASE and Cochrane Reviews were searched electronically, and their bibliographies examined to identify suitable studies for review and inclusion in a meta-analysis. Eligible studies were randomized controlled trials that reported data on relevant clinical outcomes...
April 5, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29623580/management-and-consequences-of-postoperative-fluctuations-in-plasma-sodium-concentration-after-pediatric-brain-tumor-surgery-in-the-sellar-region-a-national-cohort-analysis
#7
R W J Kruis, A Y N Schouten-van Meeteren, M J J Finken, W Oostdijk, A S P van Trotsenburg, A M Boot, H L Claahsen-van der Grinten, E J van Lindert, K S Han, E W Hoving, E M C Michiels, H M van Santen
PURPOSE: Severe fluctuations in plasma sodium concentration and plasma osmolarity, including central diabetes insipidus (CDI), may have significant influence on postoperative morbidity and mortality after pediatric brain tumor surgery.The aim of this study was to describe the frequency, severity and neurological consequences of these fluctuations in pediatric brain tumor survivors. METHODS: A retrospective, multi-institutional chart review was conducted among all children who underwent brain tumor surgery in the sellar or suprasellar region in seven university hospitals in the Netherlands between January 2004 and December 2013...
April 5, 2018: Pituitary
https://www.readbyqxmd.com/read/29620642/in-hospital-mortality-and-morbidity-of-pediatric-scoliosis-surgery-in-japan-analysis-using-a-national-inpatient-database
#8
Yuki Taniguchi, Takeshi Oichi, Junichi Ohya, Hirotaka Chikuda, Yasushi Oshima, Yoshitaka Matsubayashi, Hiroki Matsui, Kiyohide Fushimi, Sakae Tanaka, Hideo Yasunaga
Several previous reports have elucidated the mortality and incidence of complications after pediatric scoliosis surgery using nationwide databases. However, all of these studies were conducted in North America. Hence, this study aimed to identify the incidence and risk factors for in-hospital mortality and morbidity in pediatric scoliosis surgery, utilizing the Diagnosis Procedure Combination database, a national inpatient database in Japan.We retrospectively extracted data for patients aged less than 19 years who were admitted between 01 June 2010 and 31 March 2013 and underwent scoliosis surgery with fusion...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29606327/evaluation-of-a-diabetes-coach-program-aimed-to-improve-the-care-of-children-and-youth-with-type-1-diabetes-and-with-compromised-control
#9
Paola Luca, Bodiel Haugrud, Allison Husband, Jonathan Dawrant, Danièle Pacaud
OBJECTIVE: To evaluate the impact of the Diabetes Coach Program (DCP) on glycated hemoglobin (A1C) levels in youth with type 1 diabetes. The youth were referred to and participated in the DCP between October 2011 and May 2016. METHODS: The Diabetes Coach visited families in their homes every 1 to 2 weeks and updated patients' diabetes teams regularly. A1C levels before the DCP were compared with A1C levels during and after discharge from the DCP. Six participating families completed satisfaction surveys via telephone...
January 31, 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29606015/avoidant-coping-moderates-the-relationship-between-paternal-involvement-in-the-child-s-type-1-diabetes-t1d-care-and-parenting-stress
#10
Ashley Teasdale, Christine Limbers
Fathers may experience greater parenting stress and anxiety when they are more involved in their child's type 1 diabetes (T1D) care. The present study evaluated whether seeking social support and avoidant coping strategies moderate the relationship between paternal involvement in the child's T1D care and parenting stress in an international sample. Two hundred forty-nine fathers of young children with T1D completed the Parenting Stress Index (PSI), Pediatric Inventory for Parents (PIP), Dads' Active Disease Support scale (DADS), COPE Inventory, Self-Care Inventory (SCI-R), and a demographic questionnaire online...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29603040/screening-for-childhood-adversity-the-what-and-when-of-identifying-individuals-at-risk-for-lifespan-health-disparities
#11
Kate Ryan Kuhlman, Theodore F Robles, Julienne E Bower, Judith E Carroll
Existing research on childhood adversity and health risk across the lifespan lacks specificity regarding which types of exposures to assess and when. The purpose of this study was to contribute to an empirically-supported framework to guide practitioners interested in identifying youth who may be at greatest risk for a lifelong trajectory of health disparities. We also sought to identify the point in childhood at which screening for adversity exposure would capture the largest group of at risk individuals for triage to prevention and intervention services...
March 30, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29602408/an-update-on-hypertension-in-children-with-type-1-diabetes
#12
REVIEW
Mallory L Downie, Emma H Ulrich, Damien G Noone
The prevalence of hypertension in children with type 1 diabetes is reported to be between 6% and 16%. This potentially modifiable cardiovascular risk factor may go undiagnosed and undertreated, particularly in children with type 1 diabetes. Recent updated Canadian clinical practice guidelines recommend blood pressure screening every 2 years in children with type 1 diabetes as well as routine use of ambulatory blood pressure monitoring. Risk factors for hypertension in type 1 diabetes include poor glycemic control, overweight and obesity and genetic predisposition for hypertension...
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29600905/therapeutic-outcomes-of-transsphenoidal-surgery-in-pediatric-patients-with-craniopharyngiomas-a-single-center-study
#13
Shozo Yamada, Noriaki Fukuhara, Mitsuo Yamaguchi-Okada, Hiroshi Nishioka, Akira Takeshita, Yasuhiro Takeuchi, Naoko Inoshita, Junko Ito
OBJECTIVE The aim of this study was to analyze the outcomes of transsphenoidal surgery (TSS) in a single-center clinical series of pediatric craniopharyngioma patients treated with gross-total resection (GTR). METHODS The authors retrospectively reviewed the surgical outcomes for 65 consecutive patients with childhood craniopharyngiomas (28 girls and 37 boys, mean age 9.6 years) treated with TSS (45 primary and 20 repeat surgeries) between 1990 and 2015. Tumors were classified as subdiaphragmatic or supradiaphragmatic...
March 30, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29597246/importance-of-patient-provider-communication-to-adherence-in-adolescents-with-type-1-diabetes
#14
REVIEW
Niral J Patel, Karishma A Datye, Sarah S Jaser
Effective communication between pediatric diabetes patients and their providers has the potential to enhance patient satisfaction and health outcomes, as well as improve diabetes-related self-management. In this review, we highlight the importance of communication between patients and providers, focusing on the effect of communication on adherence in the high-risk population of adolescents with type 1 diabetes. We synthesize the literature describing patient-provider communication in pediatric populations and provide implications for practice that focus on the most relevant, modifiable factors for improving self-management in adolescents with type 1 diabetes...
March 28, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29596053/the-adipose-tissue-expandability-hypothesis-a-potential-mechanism-for-insulin-resistance-in-obese-youth
#15
REVIEW
Sonia Caprio, Bridget Pierpont, Romy Kursawe
Obesity has become a major global health challenge of the 21st century, as it is associated with the onset of type 2 diabetes (T2D) and cardiovascular complications, even at a very early age in life. The root causes of pediatric obesity remain incompletely understood. The obesity epidemic together with the relationship of obesity to the growing population burden of chronic disease presents unprecedented research opportunities and challenges. Decades of obesity-related research funded by governments around the world have yielded many important discoveries about both etiological pathways and preventive or therapeutic interventions...
March 29, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29594922/intensification-of-induction-therapy-and-prolongation-of-maintenance-therapy-did-not-improve-the-outcome-of-pediatric-langerhans-cell-histiocytosis-with-single-system-multifocal-bone-lesions-results-of-the-japan-langerhans-cell-histiocytosis-study-group-02
#16
Akira Morimoto, Yoko Shioda, Toshihiko Imamura, Kazuko Kudo, Toshiyuki Kitoh, Hiroshi Kawaguchi, Hiroaki Goto, Yoshiyuki Kosaka, Yukiko Tsunematsu, Shinsaku Imashuku
Langerhans cell histiocytosis (LCH) with single-system (SS) multifocal bone (MFB) lesions is rarely fatal, but patients may experience relapses and develop LCH-associated sequelae. To evaluate effect on outcomes of pediatric multifocal LCH, we tested a treatment protocol modified from the Japan Langerhans Cell Histiocytosis Study Group (JLSG)-96 study. We assessed the outcomes of all consecutive newly diagnosed pediatric patients with LCH with SS-MFB lesions who were treated with JLSG-02 protocol in 2002-2009...
March 28, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29594260/endocrine-disorders-in-primary-mitochondrial-disease
#17
Iman S Al-Gadi, Richard H Haas, Marni J Falk, Amy Goldstein, Shana E McCormack
Context: Endocrine disorders are common in individuals with mitochondrial disease. To develop evidence-based screening practices in this high-risk population, updated age-stratified estimates of the prevalence of endocrine conditions are needed. Objective: To measure the point prevalence of selected endocrine disorders in individuals with mitochondrial disease. Design Setting and Patients: The North American Mitochondrial Disease Consortium Patient Registry is a large, prospective, physician-curated cohort study of individuals with mitochondrial disease...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29582520/pediatric-endocrine-society-survey-of-diabetes-practices-in-the-united-states-what-is-the-current-state
#18
Ines Guttmann-Bauman, Paul Thornton, Soumya Adhikari, Kent Reifschneider, Michael A Wood, Tyler Hamby, Karen Rubin
The Practice Management Committee (PMC) of the Pediatric Endocrine Society (PES) conducted a survey of its membership in February/March 2016 to assess the current state of pediatric diabetes care delivery across multiple practice types in the United States. RESEARCH DESIGN AND METHODS: The PES distributed an anonymous electronic survey (Survey Monkey) via email to its membership and requested that only one survey be completed for each practice. RESULTS: Ninety-three unique entries from the US were entered into analysis...
March 26, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29581480/late-cardiovascular-morbidity-and-mortality-following-pediatric-allogeneic-hematopoietic-cell-transplantation
#19
Christine N Duncan, Ruta Brazauskas, Jiaxing Huang, Bronwen E Shaw, Navneet S Majhail, Bipin N Savani, Mary E D Flowers, Minoo Battiwalla, Kristen Beebe, Andrew C Dietz, Christopher C Dvorak, Roger Giller, David A Jacobsohn, Morris Kletzel, Paul L Martin, Eneida R Nemecek, Brandon Nuechterlein, Julie-An Talano, Michael A Pulsipher, K Scott Baker
We analyzed late cardiovascular outcomes of 661 patients who survived at least 2 years from hematopoietic cell transplantation for childhood hematologic malignancy between 1995 and 2008. Center for International Blood and Marrow Transplant Research data was supplemented with surveys focused on cardiotoxicity and potential risk factors. The median duration of follow-up was 97 months (range 24-230). 4.2% of survivors experienced at least one of the primary outcomes including coronary artery disease (0.2%), cerebrovascular accident (0...
March 26, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29577538/family-adjustment-to-diabetes-diagnosis-in-children-can-participation-in-a-study-on-type-1-diabetes-genetic-risk-be-helpful
#20
Laura B Smith, Xiang Liu, Suzanne Bennett Johnson, Roy Tamura, Helena Elding Larsson, Simi Ahmed, Riitta Veijola, Michael J Haller, Beena Akolkar, William A Hagopian, Marian J Rewers, Jeffrey Krischer, Andrea K Steck
BACKGROUND AND OBJECTIVES: Diagnosis of type 1 diabetes often causes a negative psychological impact on families. We examined whether parents and children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study differ in their psychological adjustment to diabetes diagnosis compared to children diagnosed with diabetes in the community. SUBJECTS AND METHODS: TEDDY follows 8,676 children at genetic risk for type 1 diabetes from birth. Fifty-four TEDDY children diagnosed with diabetes and 54 age-matched community control children diagnosed with diabetes were enrolled...
March 26, 2018: Pediatric Diabetes
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