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https://www.readbyqxmd.com/read/28820061/renin-angiotensin-system-and-cytokines-in-chronic-kidney-disease-clinical-and-experimental-evidence
#1
Ariadna Andrade Saldanha Silva, Beranardo Bahia Finotti, Amanda Oliveira Lauar, Thiago Ruiz Rodrigues Prestes, Ana Cristina Simões E Silva
Chronic kidney disease (CKD) has become a major public health problem in Brazil and worldwide. There are many causes of CKD, being the congenital anomalies of the kidney and urinary tract and the glomerular diseases very common in pediatric patients, while diabetic nephropathy, CKD due to chronic arterial hypertension and glomerular diseases are predominant in adult patients. Many endogenous mediators have been related to the pathophysiology of CKD, being relevant the effects of the renin-angiotensin system (RAS) and the immune-inflammatory mediators including cytokines...
August 18, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28803331/impact-of-monitoring-health-related-quality-of%C3%A2-life-in-clinical-practice-in-children-with-type-1-diabetes-mellitus
#2
Marta Murillo, Joan Bel, Jacobo Pérez, Raquel Corripio, Gemma Carreras, Xavier Herrero, Josep-Maria Mengibar, Dolors Rodriguez-Arjona, Ulrike Ravens-Sieberer, Hein Raat, Luis Rajmil
PURPOSE: To test whether the systematic monitoring of health-related quality of life (HRQOL) in clinical practice in Spanish pediatric patients with T1DM helps improve their daily life in a multicenter longitudinal study. METHODS: One hundred thirty-six patients participated, recruited from five centers in Barcelona, Spain (72 girls, mean age 13.4 years). Complete data were collected for 119 patients (85%). Pediatricians were randomly assigned to the HRQOL intervention (n = 70), or control group (n = 49)...
August 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28800051/alternative-tests-versus-measurement-of-fasting-plasma-glucose-and-oral-glucose-tolerance-test-for-diagnosis-of-pediatric-type-2-pre-diabetes-a-systematic-review-protocol
#3
Dagmar Tučková, Miloslav Klugar, Tomasz Lasota, Jakub Lasák, Jared M Campbell, Zachary Munn
The gold standard for the diagnosis of pre-diabetes is the measurement of fasting plasma glucose and the oral glucose tolerance test. The objective of this systematic review is to identify all alternative tests currently in use for the diagnosis of type 2 pre-diabetes mellitus in children and establish their accuracy relative to this gold standard.
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28780619/evaluation-of-optic-disc-retinal-nerve-fiber-and-macular-ganglion-cell-layers-in-pediatric-diabetes
#4
Evre Pekel, Selda Ayça Altıncık, Gökhan Pekel
PURPOSE: Our aim was to compare optic disc parameters, retinal nerve fiber (RNFL) and macular ganglion cell layers between children and adolescents with diabetes mellitus (type 1) and healthy controls. METHODS: Sixty-three eyes of 63 pediatric diabetic patients without diabetic retinopathy and 44 eyes of 44 healthy controls were included in this cross-sectional and comparative study. Diabetic and control groups were similar in the aspect of age, gender and refractive error...
August 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28761657/improving-the-transition-from-pediatric-to-adult-diabetes-care-the-pediatric-care-provider-s-perspective-in-quebec-canada
#5
Meranda Nakhla, Lorraine E Bell, Sarah Wafa, Kaberi Dasgupta
OBJECTIVES: The transition from pediatric to adult care is a high-risk period for the emerging adult with diabetes. We aimed to determine adequacy of pediatric transition care structures and explore the pediatric diabetes care provider's perceptions of transition care. RESEARCH DESIGN AND METHODS: In-depth interviews with pediatric diabetes care providers from 12 diabetes centers in Quebec were conducted. We queried alignment with Got Transition's six core elements of healthcare transition, experiences, and barriers to transition care...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28760727/randomized-trial-comparing-the-electronic-composite-psychosocial-screener-youthchat-with-a-clinician-interview-assessment-for-young-people-a-study-protocol
#6
Hiran Thabrew, Arden Corter, Felicity Goodyear-Smith, Mary Goldfinch
BACKGROUND: Psychosocial problems such as depression, anxiety, and substance abuse are common and burdensome in young people, particularly those with long-term physical conditions such as asthma and diabetes. In New Zealand, "screening" for such problems is undertaken routinely only with Year 9 students in low-decile schools and opportunistically in pediatric settings using a nonvalidated and time-consuming clinician-administered Home, Education/employment, Eating, Activity, Drugs, Sexuality, Suicide/depression, Safety (HEEADSSS) interview...
July 31, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28755385/building-and-validating-a-prediction-model-for-pediatric-type-1-diabetes-risk-using-next-generation-targeted-sequencing-of-class-ii-hla-genes
#7
Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Eva Örtqvist, Chul-Woo Pyo, Hamid Bolouri, Michael Zhao, Wyatt C Nelson, Daniel E Geraghty, Åke Lernmark
AIM: It is of interest to predict possible lifetime risk of type diabetes (T1D) in young children for recruiting high-risk subjects into longitudinal studies of effective prevention strategies. METHODS: Utilizing a case-control study in Sweden, we applied a recently developed next generation targeted sequencing (NGTS) technology to genotype class II genes, and applied an object-oriented regression (OOR) to build and validate a prediction model for T1D. RESULTS: In the training set, estimated risk scores were significantly different between patients and controls (P=8...
July 29, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28751985/public-awareness-regarding-common-eye-diseases-among-saudi-adults-in-riyadh-city-a-quantitative-study
#8
Waleed A Al Rashed, Amro K Bin Abdulrahman, Ahmed A Zarban, Mohammed S Almasri, Abdulrahman S Mirza, Rajiv Khandekar
AIM: The current study aimed to evaluate the knowledge of eye disease and awareness of eye care among the Saudi adults and to explore existing eye-related misconceptions in the community. METHODS: A cross-sectional study was conducted in Riyadh city during May and June 2016. A self-administered anonymous online questionnaire was used to explore the most common misconceptions related to eye diseases and eye care. RESULTS: Out of 1000 individuals, only 711 (71...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28749844/effect-of-preserving-the-pituitary-stalk-during-resection-of-craniopharyngioma-in-children-on-the-diabetes-insipidus-and-relapse-rates-and-long-term-outcomes
#9
Jing Cheng, Yanqin Fan, Bo Cen
OBJECTIVE: The objective of this study was to investigate the effect of preserving an infiltrated pituitary stalk during the resection of craniopharyngioma of pituitary stalk origin on postoperative outcomes and thus provide a theoretical basis for microsurgical treatment and prognosis. METHODS: We screened the clinical data of all 103 pediatric patients with craniopharyngioma undergoing surgical treatment at our department between January 2006 and January 2013 and conducted a retrospective analysis of 82 patients with craniopharyngioma originating in the pituitary stalk...
July 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28749817/prednisolone-and-prednisone-pharmacokinetics-in-pediatric-renal-transplant-recipients-a-prospective-study
#10
Ragnhild Heier Skauby, Anna Bjerre, Ingjerd Sæves, Nils Tore Vethe, Sara Bremer, Anja Svarstad, Stein Bergan
BACKGROUND: Prednisolone is a standard component of immunosuppressive protocols in renal transplantation (Tx) and despite standardized treatment regimens, adverse side effects are still frequent. The aim of this study was to characterize the pharmacokinetics of prednisolone and prednisone in pediatric renal transplant recipients in the first 52 weeks post Tx, to describe the relationship between prednisolone and prednisone, and to investigate a possible relationship between the development of new onset diabetes after Tx (NODAT) and glucocorticoid exposure...
July 26, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28748894/collagenofibrotic-collagen-type-iii-glomerulopathy-in-association-with-diabetic-nephropathy
#11
Khaled O Alsaad, Burhan Edrees, Khawla A Rahim, Abdulkareem Alanazi, Muawia Ahmad, Noura Aloudah
Collagenofìbrotic (collagen type III) glomerulopathy (CG) is a rare nonimmune-mediated glomerular disease. It is characterized by massive deposition of organized collagen type III fibers, which is localized in the mesangial and subendothelial glomerular areas and associated with increased serum levels of procollagen type III peptide. Association with systemic diseases and malignancies is extremely rare. Herein, we present a case of a nine-year-old girl, known case of type I diabetes mellitus, who presented with fever, nephrotic range proteinuria, generalized edema, and hypertension...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28747349/outcomes-associated-with-a-pediatric-clinical-diabetes-network-in-ontario-a-population-based-time-trend-analysis
#12
Meranda Nakhla, Elham Rahme, Marc Simard, Astrid Guttmann
BACKGROUND: The Network of Ontario Pediatric Diabetes Programs was implemented in 2001. The objective of this study was to determine whether implementation of the network was associated with a decrease in the risk of acute diabetes-related complications and a reduction in the socioeconomic and geographic disparities in these outcomes. METHODS: We conducted a population-based time trend analysis of children (< 18 yr) with diabetes using health administrative databases in Ontario from 1996 to 2011...
July 24, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28745094/nich-at-its-best-for-diabetes-at-its-worst-texting-teens-and-their-caregivers-for-better-outcomes
#13
David V Wagner, Samantha A Barry, Maggie Stoeckel, Lena Teplitsky, Michael A Harris
BACKGROUND: There is growing evidence for the feasibility of text-based interventions for pediatric patients with type 1 diabetes (T1D). However, less is known regarding whether the use of personalized text messages with high-risk youth and their caregivers is associated with improvements in youth health. This study examines the use of diabetes-specific texts and associated health outcomes for participants of the Novel Interventions in Children's Healthcare (NICH) program. METHODS: Text messages sent to youth with T1D and their caregivers during NICH intervention were coded regarding diabetes relevance and adherence-related content...
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28745034/transglutaminase-antibodies-and-celiac-disease-in-children-with-type-1-diabetes-and-in-their-family-members
#14
Anna Parkkola, Taina Härkönen, Samppa J Ryhänen, Raivo Uibo, Jorma Ilonen, Mikael Knip
OBJECTIVES: We set out to determine the prevalence of tissue transglutaminase antibodies (anti-tTG) and celiac disease (CD) in children with newly diagnosed type 1 diabetes (T1D) and their first-degree relatives (FDR). The hypothesis was that the individuals with both diabetes and CD form a distinct subgroup in terms of human leukocyte antigen (HLA) class II genetics, islet autoantibodies, and clinical characteristics at diabetes diagnosis. SUBJECTS AND METHODS: This population-based observational study included 745 index children with T1D and their 2692 FDR from the Finnish Pediatric Diabetes Register...
July 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28744992/the-effect-of-12-weeks-carnosine-supplementation-on-renal-functional-integrity-and-oxidative-stress-in-pediatric-patients-with-diabetic-nephropathy-a-randomized-placebo-controlled-trial
#15
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Abdel Rahman El-Naggar, Mahitab Hany Hamouda, Manal El-Hamamsy
BACKGROUND AND OBJECTIVES: Oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. Carnosine is a natural radical oxygen species scavenger. We investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion (UAE), the tubular damage marker alpha 1-microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy. METHODS: This randomized placebo-controlled trial included 90 patients with diabetic nephropathy, despite oral angiotensin-converting enzyme inhibitors (ACE-Is), who were randomly assigned to receive either 12 weeks of carnosine 1 g/day (n = 45), or matching placebo (n = 45)...
July 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28742518/severe-hypertriglyceridemia-at-new-onset-type-1-diabetes-mellitus
#16
Tyler Fick, Julie Jack, Amy L Pyle-Eilola, Rohan K Henry
BACKGROUND: Severe hypertriglyceridemia (HTG) as well as diabetic ketoacidosis (DKA) are complications of type 1 diabetes (T1DM). HTG is an exceedingly rare complication in the pediatric population and herein we report a case of HTG at new-onset T1DM in DKA and discuss management and potential complications. CASE PRESENTATION: An 11-year-old previously well patient with a history of fatigue and weight loss presented with: glucose >600 mg/dL, venous blood gas: pH 7...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28739653/the-metabolic-syndrome-in-children-and-adolescents-shifting-the-focus-to-cardiometabolic-risk-factor-clustering
#17
Sheela N Magge, Elizabeth Goodman, Sarah C Armstrong
Metabolic syndrome (MetS) was developed by the National Cholesterol Education Program Adult Treatment Panel III, identifying adults with at least 3 of 5 cardiometabolic risk factors (hyperglycemia, increased central adiposity, elevated triglycerides, decreased high-density lipoprotein cholesterol, and elevated blood pressure) who are at increased risk of diabetes and cardiovascular disease. The constellation of MetS component risk factors has a shared pathophysiology and many common treatment approaches grounded in lifestyle modification...
July 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28737859/association-between-dietary-glycemic-load-and-metabolic-syndrome-in-obese-children-and-adolescents
#18
Angela Cornejo-Monthedoro, Isel Negreiros-Sánchez, Carlos Del Águila, Marlit Ysla-Marquillo, Percy Mayta-Tristán
OBJETIVE: To study the association between the metabolic syndrome (MS) and the glycemic load (GL) of food intake among obese children and adolescents seen in consultation by the endocrinology team in a pediatric referral hospital in Lima, Peru. POPULATION AND METHOD: Cross-sectional study among obese children and adolescents (body mass index ≥ 95 percentile), 10-15 years old. The MS was classified according to criteria of the International Diabetes Federation...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737266/nephrolithiasis-a-complication-of-pediatric-diabetic-ketoacidosis
#19
Sungeeta Agrawal, Robin Kremsdorf, Serife Uysal, Meghan E Fredette, Lisa Swartz Topor
OBJECTIVE: To determine the frequency of nephrolithiasis as a complication of diabetic ketoacidosis (DKA) in pediatrics. METHODS: We performed a retrospective chart review of patients with DKA admitted to a pediatric hospital between January 2009 and July 2016. We identified patients with nephrolithiasis during admission for DKA. RESULTS: We identified 395 episodes of DKA over 7.5 years. Nephrolithiasis developed as a complication of DKA in 3 of those admissions (0...
July 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28731931/renal-function-and-its-association-with-blood-pressure-in-middle-eastern-immigrants-and-native-swedes
#20
Christopher Nilsson, Anders Christensson, Peter M Nilsson, Louise Bennet
BACKGROUND: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicities in renal function as a possible explanation to the paradox. METHODS: A population-based, cross-sectional study of men and women, born in Iraq or Sweden, aged 30-75 years was conducted in Malmö, Sweden, from 2010 to 2012...
July 20, 2017: Journal of Hypertension
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