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https://www.readbyqxmd.com/read/28205426/a-study-of-hla-b-15-02-in-9-different-chinese-ethnics-implications-for-carbamazepine-related-sjs-ten
#1
G J Ou, J Wang, X Ji, H Yu, L Jiang, L Li, Q Chen, P C Su, Z Liu
BACKGROUND: HLA-B*15:02 is a known biomarker for carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations. The US FDA recommends B*15:02 screening for Asian and other populations with a high prevalence of B*15:02 prior to treatment with CBZ to prevent drug-related SJS/TEN. MATERIALS AND METHODS: A total of 1607 blood samples were collected from volunteer blood donors who were ethnic minorities living in the Yunnan province of southwestern China, including 153 Yi, 193 Naxi, 167 Miao, 156 Lisu, 166 Derung, 211 Bai, 184 Hani, 198 Dai, and 179 Zhuang...
February 15, 2017: HLA
https://www.readbyqxmd.com/read/28202065/alternative-transmission-routes-in-the-malaria-elimination-era-an-overview-of-transfusion-transmitted-malaria-in-the-americas
#2
Regina M Alho, Kim Vinícius Amaral Machado, Fernando F A Val, Nelson A Fraiji, Marcia A A Alexandre, Gisely C Melo, Judith Recht, André M Siqueira, Wuelton M Monteiro, Marcus V G Lacerda
BACKGROUND: Transfusion-transmitted (TT) malaria is an alternative infection route that has gained little attention from authorities, despite representing a life-threatening condition. There has been no systematic review of this health problem in American countries. The aim of this study was to describe the clinical and epidemiological characteristics of TT malaria in the Americas and identify factors associated with lethality based on the studies published in the literature. METHODS: Potentially relevant papers in all languages were retrieved from MEDLINE and LILACS...
February 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28194857/hepatitis-e-risks-pigs-or-blood-that-is-the-question
#3
Richard S Tedder, Samreen Ijaz, Alan Kitchen, Ines Ushiro-Lumb, Kate I Tettmar, Patricia Hewitt, Nick Andrews
BACKGROUND: Infection with hepatitis E virus (HEV) Genotype 3 is recognized as a food-borne zoonosis in developed countries where it usually causes a mild self-limited acute hepatitis. It may cause a persistent infection in the immunosuppressed human that can progress to cirrhosis. To protect the patient from transfusion-acquired HEV infection, steps have been taken in the United Kingdom to provide for at-risk patients only components from donors screened for HEV viremia. This strategy does not protect from dietary exposure and calls into question estimation of relative risk between blood transfusion and diet...
February 2017: Transfusion
https://www.readbyqxmd.com/read/28194856/the-association-of-elevated-alanine-aminotransferase-levels-with-hepatitis-e-virus-infections-among-blood-donors-in-china
#4
Meiyu Wang, Miao He, Binting Wu, Ling Ke, Tingting Han, Jingxing Wang, Hua Shan, Paul Ness, Nan Guo, Yu Liu, Kenrad E Nelson
BACKGROUND: Transfusion transmission of hepatitis E virus (HEV) is an emerging health risk, yet blood donors are rarely screened for this pathogen. Many blood centers instituted screening of blood donors for elevated levels of alanine aminotransferase (ALT) levels to prevent hepatitis C virus, which has continued in China. We evaluated whether elevated ALT levels were associated with HEV among blood donors in China. STUDY DESIGN AND METHODS: Blood samples were collected from 9069 qualified volunteer blood donors from four blood centers in China...
February 2017: Transfusion
https://www.readbyqxmd.com/read/28194799/relative-analytical-sensitivity-of-donor-nucleic-acid-amplification-technology-screening-and-diagnostic-real-time-polymerase-chain-reaction-assays-for-detection-of-zika-virus-rna
#5
Mars Stone, Marion C Lanteri, Sonia Bakkour, Xutao Deng, Susan A Galel, Jeffrey M Linnen, Jorge L Muñoz-Jordán, Robert S Lanciotti, Maria Rios, Pierre Gallian, Didier Musso, José E Levi, Ester C Sabino, Lark L Coffey, Michael P Busch
BACKGROUND: Zika virus (ZIKV) has spread rapidly in the Pacific and throughout the Americas and is associated with severe congenital and adult neurologic outcomes. Nucleic acid amplification technology (NAT) assays were developed for diagnostic applications and for blood donor screening on high-throughput NAT systems. We distributed blinded panels to compare the analytical performance of blood screening relative to diagnostic NAT assays. STUDY DESIGN AND METHODS: A 25-member, coded panel (11 half-log dilutions of a 2013 French Polynesia ZIKV isolate and 2015 Brazilian donor plasma implicated in transfusion transmission, and 3 negative controls) was sent to 11 laboratories that performed 17 assays with 2 to 12 replicates per panel member...
February 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28194794/mutations-of-the-klf1-gene-detected-in-japanese-with-the-in-lu-phenotype
#6
Miho Kawai, Kumi Obara, Takayuki Onodera, Takayuki Enomoto, Kenichi Ogasawara, Hatsue Tsuneyama, Makoto Uchikawa, Shoichi Inaba
BACKGROUND: In(Lu) is characterized by a reduced expression of antigens in the Lutheran blood group system as well as other blood group antigens. Mutations of the erythroid transcription factor, KLF1, have been reported to cause the In(Lu) phenotype, and we investigated Japanese In(Lu) to estimate the prevalence of the phenotype and KLF1 polymorphism. STUDY DESIGN AND METHODS: Blood samples were screened by monoclonal anti-CD44 and the In(Lu) phenotype was confirmed by tube tests including adsorption and elution tests using anti-Lu(a) and anti-Lu(b) ...
February 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28186642/higher-calcineurin-inhibitor-levels-predict-better-kidney-graft-survival-in-patients-with-de-novo-donor-specific-anti-hla-antibodies-a-cohort-study
#7
Marc-Antoine Béland, Isabelle Lapointe, Réal Noël, Isabelle Côté, Eric Wagner, Julie Riopel, Eva Latulippe, Olivier Désy, Stéphanie Béland, Ciara N Magee, Isabelle Houde, Sacha A De Serres
The development of de novo anti-HLA donor specific antibodies (dnDSA) is associated with poorer outcomes in kidney transplant recipients. Despite this, antibody screening post-transplant is not widespread, largely because the optimal management of patients with dnDSA remains undetermined. We hypothesized that in this population, calcineurin inhibitor blood levels would be an independent predictor of graft loss. We analyzed a cohort of unsensitized patients for whom anti-HLA antibody screening was performed prospectively post-transplant...
February 10, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28185828/the-role-of-molecular-typing-and-perfect-match-transfusion-in-sickle-cell-disease-and-thalassaemia-an-innovative-transfusion-strategy
#8
Rossana Putzulu, Nicola Piccirillo, Nicoletta Orlando, Giuseppina Massini, Maddalena Maresca, Fernando Scavone, Bianca Maria Ricerca, Gina Zini
Chronic red blood cell transfusions remain an essential part of supportive treatment in patients with thalassaemia and sickle cell disease (SCD). Red blood cell (RBC) transfusions expose patients to the risk of developing antibodies: RBC alloimmunization occurs when the immune system meets foreign antigens. We created a register of extensively genotyped donors to achieve a better matched transfusion in order to reduce transfusion alloimmunization. Extended RBC antigen typing was determined and confirmed by molecular biology techniques using Human Erythrocyte Antigen (HEA) BeadChip (BioArray Solutions Ltd...
January 23, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28185278/zika-virus-and-blood-transfusion-the-experience-of-french-polynesia
#9
Damien Bierlaire, Sylvie Mauguin, Julien Broult, Didier Musso
BACKGROUND: Between October 2013 and March 2014, French Polynesia experienced the largest Zika virus (ZIKV) outbreak ever described before the emergence of ZIKV in the Americas in 2015. As arbovirus transfusion-transmitted (TT) infections have been previously reported, we hypothesized that transfusion of blood products could also transmit ZIKV. STUDY DESIGN AND METHODS: Mitigation strategies to prevent ZIKV-TT infections included nonspecific measures and the implementation of a laboratory developed ZIKV-specific nucleic acid testing (NAT) assay...
February 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28168852/hemoglobin-screening-in-blood-donors-a-prospective-study-assessing-the-value-of-an-invasive-and-a-noninvasive-point-of-care-device-for-donor-safety
#10
Dorien De Clippel, Leen Van Heddegem, Giovani Vandewalle, Philippe Vandekerckhove, Veerle Compernolle
BACKGROUND: Low hemoglobin (Hb) levels are a common reason for whole blood donor deferral. As some of the deferred donors do not return to donate blood later, the development of accurate tools to reliably detect low Hb levels is therefore important for donor safety and retention. STUDY DESIGN AND METHODS: In a prospective study, 1483 whole blood donors were enrolled in three study arms. In each study arm the Hb results measured with a point-of-care testing device were compared with the venous Hb results obtained in our central laboratory...
February 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28164536/development-of-real-time-pcr-and-melting-curve-analysis-for-the-rapid-detection-of-del-with-rhd-c-1222t-c-or-rhd-c-1227g-a
#11
Yun Ji Hong, Hyungsuk Kim, Eun Young Song, Duck Cho, Kyoung Un Park, Kyou-Sup Han
BACKGROUND: DEL, a variant of RhD, is difficult to detect in routine blood bank testing owing to its extremely low levels of D antigen expression. However, DEL is capable of alloimmunizing a patient when transfused into RhDnegative individuals. METHODS: In this study, we developed real-time PCR and melting curve analysis for the rapid detection of the DEL phenotype. RESULTS: Of the 325 serologically RhD-negative individuals involved in the study, 56 (17...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164494/the-blood-bank-for-diabetes-screening-a-feasible-alternative
#12
Mauren I Anghebem-Oliveira, Claudia D Costa, Giorgio R Baldanzi, Juliane C Schmitt-Mansur, Geraldo Picheth, Fabiane G M Rego
BACKGROUND: Vascular complications of diabetes mellitus (DM) are associated with 5% of deaths globally every year. Early diagnosis and treatment could reduce this figure. The aim of this project was to investigate the frequency of undiagnosed DM among blood donors and the possibility of blood banks participating in DM screening. METHODS: Of the approximate 5,600 candidates for blood donation who were evaluated, 4,601 were considered suitable. Candidates with any type of DM, hypertension, thyroid disease, and/or continuous use of any drugs were excluded, resulting in the participation of 635 donors aged 18 - 69 years...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28164313/the-characteristics-of-hepatitis%C3%A2-b-surface-antigen-hbsag-negative-hepatitis%C3%A2-b-virus-hbv-infection-in-chinese-blood-donors-a-follow-up-study-of-donors-tested-negative-for-hbsag-and-reactive-for-simultaneous-nucleic-acid-testing-of-hbv-hepatitis%C3%A2-c-virus-and
#13
Zhaofu Guo, Ping Fu, Yijin Yin, Funeng Wang, Yiqing Yin, Jingxing Wang, Yu Liu
BACKGROUND: The real infection status of hepatitis B virus (HBV) of hepatitis B surface antigen (HBsAg)-negative yet nucleic acid test (NAT)-positive blood donors is difficult to clarify. Detailed follow-up study is needed for analyzing the infectivity of these blood donors. STUDY DESIGN AND METHODS: Blood donors who screened negative for HBsAg and reactive for simultaneous NAT of HBV, hepatitis C virus (HCV), and human immunodeficiency virus (HIV) were included in a follow-up epidemiologic questionnaire survey and contributed follow-up samples for further testing...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28164310/first-zika-positive-donations-in-the-continental-united-states
#14
Susan A Galel, Phillip C Williamson, Michael P Busch, Danielle Stanek, Sonia Bakkour, Mars Stone, Kai Lu, Scott Jones, Susan N Rossmann, Lisa Lee Pate
BACKGROUND: Zika virus (ZIKV) has spread in the Americas, including parts of the southern United States, and infection can be associated with serious complications, including congenital brain abnormalities. Probable transfusion transmission of ZIKV has been documented in Brazil. STUDY DESIGN AND METHODS: Preemptive testing of blood donations for ZIKV RNA was implemented in southern US states at risk of local transmission using a test approved under a Food and Drug Administration (FDA) investigational new drug application, cobas Zika...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28159698/serum-immune-response-of-pearl-oyster-pinctada-fucata-to-xenografts-and-allografts
#15
Jinfen Wei, Baosuo Liu, Sigang Fan, Bo Zhang, Jiaqi Su, Dahui Yu
The mantle piece from the donor pearl oyster would be rejected by the immune system of recipient oyster in pearl culture practice, especially in the case that the donor and receptor are different species. Thus, investigation of the immune response of recipient oyster to grafted mantle pieces, particularly to xenografts, is of importance in creating xenograft transplantation technology for pearl culture industry. The humoral immune responses of P. fucata to allograft (mantle piece of P. fucata) and xenografts (mantle pieces of P...
January 31, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28153706/gene-analysis-of-two-cases-with-cisab-b-blood-subgroup
#16
Li-Xin Jiao, Jiang-Hong Yu, Xiao-Li Yu, Lin Chen, Yu Han, Fan Yang
OBJECTIVE: To identify the precise ABO blood type subgroups with genotyping. METHOD: We screened ABO blood type from voluntary blood donors in our blood collection center. Samples were first examined with a routine serological method. Samples with ambiguous results were further examined with genotyping to identify ABO subgroups. RESULTS: Two samples identified as AweakB by serology were considered to be A/B and B/B by PCR-SSP. However, the gene sequencing results revealed the precise subgroup to be CisAB01/B101 and CisAB05/B101, respectively...
December 21, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28151391/variant-creutzfeldt-jakob-disease-deferral-in-canada-impact-of-stop-dates
#17
Sheila F O'brien, Wenli Fan, Qi-Long Yi, Samra Uzicanin, Lori Osmond, Mindy Goldman
BACKGROUND: To reduce the risk of variant Creutzfeldt-Jakob disease (vCJD) transmission via blood transfusion in Canada, potential donors who spent a cumulative time in the United Kingdom, Western Europe or Saudi Arabia are deferred. "Stop dates" for accumulated time were later implemented for 3 months spent in the United Kingdom or France (1980-1996) and for 5 years elsewhere in Western Europe (1980-2007); Saudi Arabia deferral was implemented with the "stop date" (1980-1996). We evaluated the long-term impact of these deferrals and "stop dates", as well as the consistency of donors' answers to post-implementation screening questions...
December 15, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28150363/blood-donation-and-testosterone-replacement-therapy
#18
Benjamin Chin-Yee, Alejandro Lazo-Langner, Terrie Butler-Foster, Cyrus Hsia, Ian Chin-Yee
BACKGROUND: Polycythemia is the most common adverse effect of testosterone replacement therapy (TRT) and may predispose patients to adverse vascular events. Current Canadian guidelines recommend regular laboratory monitoring and discontinuing TRT or reducing the dose if the hematocrit exceeds 54% (hemoglobin ≥180 g/L). This threshold has been interpreted by some physicians and patients to indicate the need for phlebotomy or blood donation while on TRT. STUDY DESIGN AND METHODS: We reviewed all male blood donors in Southwestern Ontario at Canadian Blood Services from December 2013 to March 2016 who self-identified or were found on donor screening to be on TRT...
February 1, 2017: Transfusion
https://www.readbyqxmd.com/read/28144956/cost-effectiveness-of-the-screening-of-blood-donations-for-hepatitis-e-virus-in-the-netherlands
#19
Anneke S de Vos, Mart P Janssen, Hans L Zaaijer, Boris M Hogema
BACKGROUND: The incidence of hepatitis E virus (HEV) has increased substantially in Europe recently, thereby threatening blood safety. A cost-effectiveness analysis for HEV screening of blood donations in the Netherlands was performed. STUDY DESIGN AND METHODS: A simulation model was developed to mimic the process of donation, infections in the donor population, donation testing, and transmission to transfusion recipients. The variability of viral loads among donors was modeled using observed loads...
January 31, 2017: Transfusion
https://www.readbyqxmd.com/read/28137274/seroprevalence-and-geographical-distribution-of-human-t-lymphotropic-virus-type-1-among-volunteer-blood-donors-in-endemic-areas-of-iran
#20
Gharib Karimi, Maryam Zadsar, Ali Akbar Pourfathollah
BACKGROUND: Human T-cell lymphotrophic virus type 1 (HTLV-1) has a worldwide distribution and it is endemic in some regions of Iran. One of the most important routes of HTLV-1 transmission is via transfusion of contaminated blood components. The risk of transmission through asymptomatic blood donors, particularly in endemic areas should be considered and appropriately managed. The main objective of this study was to determine the seroprevalence and description the geographic distribution of HTLV-1 among voluntary blood donors in Iran...
January 30, 2017: Virology Journal
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