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https://www.readbyqxmd.com/read/29788937/seroprevalence-of-transfusion-transmissible-infections-hbv-hcv-syphilis-and-hiv-among-prospective-blood-donors-in-a-tertiary-health-care-facility-in-calabar-nigeria-an-eleven-years-evaluation
#1
Henshaw Uchechi Okoroiwu, Ifeyinwa Maryann Okafor, Enosakhare Aiyudubie Asemota, Dorathy Chioma Okpokam
BACKGROUND: Provision of constant and safe blood has been a public health challenge in Sub-Saharan Africa with high prevalence of transfusion-transmissible infections (TTIs). This study was aimed at determining the trend and seroprevalence of HBV, HCV, syphilis and HIV across the years within study among prospective blood donors at blood bank in University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria. METHODS: A retrospective analysis of blood donor data from January 2005 to December 2016 was conducted in Blood Bank/Donor Clinic of University of Calabar Teaching Hospital, Calabar, Nigeria...
May 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29765295/incentives-for-blood-donation-a-discrete-choice-experiment-to-analyze-extrinsic-motivation
#2
Andrew Sadler, Ling Shi, Susanne Bethge, Axel Mühlbacher
Background: Demographic trends affect size and age structure of populations. One of the consequences will be an increasing need for blood products to treat age-related diseases. Donation services rely on voluntariness and charitable motivation. It might be questioned whether there will be sufficient blood supply with voluntary donation. The present study focused on elicitation of preferences for incentives and aimed to contribute to the discussion on how to increase donation rates. Methods: A self-administered discrete choice experiment (DCE) was applied...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29762749/siemens-immulite-aspergillus-specific-igg-assay-for-chronic-pulmonary-aspergillosis-diagnosis
#3
Iain D Page, Malcolm D Richardson, David W Denning
Chronic pulmonary aspergillosis (CPA) complicates underlying lung disease, including treated tuberculosis. Measurement of Aspergillus-specific immunoglobulin G (IgG) is a key diagnostic step. Cutoffs have been proposed based on receiver operating characteristic (ROC) curve analyses comparing CPA cases to healthy controls, but performance in at-risk populations with underlying lung disease is unclear. We evaluated optimal cutoffs for the Siemens Immulite Aspergillus-specific IgG assay for CPA diagnosis in relation to large groups of healthy and diseased controls with treated pulmonary tuberculosis...
May 14, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29762364/seroprevalence-of-toxoplasma-gondii-infection-among-%C3%AE-thalassemia-major-pediatric-population-implications-for-transfusion-transmissible-toxoplasmosis
#4
Nora El-Tantawy, Ahmad Darwish, Eman Eissa
BACKGROUND: Children with β-thalassemia major who regularly receive blood transfusion are at risk of developing transfusion-transmitted infection. Toxoplasmosis is a common and a serious parasitic disease with high prevalence and could be transmitted through blood transfusion from healthy asymptomatic donors. However, screening Toxoplasma gondii before blood donation has not been considered. OBJECTIVE: To determine the prevalence of T. gondii antibodies among thalassemia children undergoing blood transfusion...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29757135/a-nationwide-retrospective-study-on-prevalence-of-hepatitis-e-virus-infection-in-italian-blood-donors
#5
Enea Spada, Simonetta Pupella, Giulio Pisani, Roberto Bruni, Paola Chionne, Elisabetta Madonna, Umbertina Villano, Matteo Simeoni, Sara Fabi, Giuseppe Marano, Cinzia Marcantonio, Patrizio Pezzotti, Anna R Ciccaglione, Giancarlo M Liumbruno
BACKGROUND: In Europe, hepatitis E virus (HEV) infection is mainly a food-borne zoonosis, but it can also be transmitted by blood transfusion. It is usually a mild and self-limited infection. However, immunocompromised persons, who are also those more likely to undergo blood transfusions, may develop chronic hepatitis and often cirrhosis. Since this is a potential threat to blood safety, we aimed to investigate HEV prevalence in Italian blood donors. MATERIALS AND METHODS: We used plasma donations collected during 2015-2016 by blood services (BS) scattered throughout the Italian regions and intended for the production of plasma-derived medicines...
May 4, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29747680/first-report-of-cytauxzoon-sp-infection-in-domestic-cats-in-switzerland-natural-and-transfusion-transmitted-infections
#6
Alice Nentwig, Marina L Meli, Johanna Schrack, Iris M Reichler, Barbara Riond, Corinne Gloor, Judith Howard, Regina Hofmann-Lehmann, Barbara Willi
BACKGROUND: Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids. Cytauxzoon felis induces severe and often fatal disease in domestic cats. In Europe, clinical and subclinical infections caused by Cytauxzoon sp. are described. We report the first cases of Cytauxzoon sp. infection in domestic cats in Switzerland. METHODS: Clinical and laboratory data and results of PCR analyses were collected from Cytauxzoon sp. PCR-positive cats and the cats followed for up to 851 days...
May 10, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29743768/epidemiological-analysis-of-extended-spectrum-beta-lactamase-producing-bacterial-infections-in-adult-live-donor-liver-transplant-patients
#7
Ajeet Singh, Deepak Govil, Usha Krishan Baveja, Anand Gupta, Neha Tandon, Shrikanth Srinivasan, Sachin Gupta, Sweta J Patel, Sanjiv Saigal, Arvinder Singh Soin
Introduction: Bacterial infections are a leading cause of morbidity and mortality in patients receiving solid-organ transplants. Extended-spectrum beta-lactamases (ESBL) pathogens are the most important pathogenic bacteria infecting these patients. Aim: This study aims to evaluate for the incidence and characteristics of ESBL-positive organism, to look for the clinical outcomes in ESBL-positive infected cases, and to evaluate and draft the antibiotic policy in posttransplant patients during the first 28 days posttransplant...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29742375/investigational-testing-for-zika-virus-among-u-s-blood-donors
#8
MULTICENTER STUDY
Paula Saá, Melanie Proctor, Gregory Foster, David Krysztof, Colleen Winton, Jeffrey M Linnen, Kui Gao, Jaye P Brodsky, Ronald J Limberger, Roger Y Dodd, Susan L Stramer
BACKGROUND: Because of the potential severe clinical consequences of Zika virus (ZIKV) infection, the large numbers of asymptomatic travelers returning from ZIKV-active areas, the detection of ZIKV nucleic acid in blood, and reports of transmission of ZIKV through transfusion, in 2016 the Food and Drug Administration released recommendations for individual-unit nucleic acid testing to minimize the risk of transmission of ZIKV through blood transfusions. METHODS: The American Red Cross implemented investigational screening of donated blood for ZIKV RNA by means of transcription-mediated amplification (TMA)...
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29740429/rapid-flow-cytometry-based-test-for-the-diagnosis-of-lipopolysaccharide-responsive-beige-like-anchor-lrba-deficiency
#9
Laura Gámez-Díaz, Elena C Sigmund, Veronika Reiser, Werner Vach, Sophie Jung, Bodo Grimbacher
The diagnosis of lipopolysaccharide-responsive beige-like-anchor-protein (LRBA) deficiency currently relies on gene sequencing approaches that do not support a timely diagnosis and clinical management. We developed a rapid and sensitive test for clinical implementation based on the detection of LRBA protein by flow cytometry in peripheral blood cells after stimulation. LRBA protein was assessed in a prospective cohort of 54 healthy donors and 57 patients suspected of LRBA deficiency. Receiver operating characteristics analysis suggested an LRBA:MFI ratio cutoff point of 2...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29721197/backtracked-analysis-of-preleukemic-fusion-genes-and-dna-repair-foci-in-umbilical-cord-blood-of-children-with-acute-leukemia
#10
Milan Škorvaga, Matúš Durdík, Pavol Košík, Eva Marková, Marek Holop, Miroslav Kubeš, Judita Puškáčová, Alexandra Kolenová, Igor Belyaev
The first event in origination of many childhood leukemias is a specific preleukemic fusion gene (PFG) that arises, often in utero, in hematopoietic stem/progenitor cells (HSPC) from misrepaired DNA double strand break (DSB). An immanently elevated level of DSB and impaired apoptosis may contribute to origination and persistence of PFG and donor cell-derived leukemia in recipients of allogeneic transplantation of umbilical cord blood (UCB). We investigated DSB, apoptosis and PFG in the backtracked UCB cells of leukemic patients...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29709983/low-seroprevalence-of-severe-fever-with-thrombocytopenia-syndrome-virus-antibodies-in-individuals-living-in-an-endemic-area-of-japan
#11
Mutsuyo Gokuden, Shuetsu Fukushi, Masayuki Saijo, Fumiko Nakadouzono, Yuka Iwamoto, Mami Yamamoto, Nodoka Hozumi, Kouichiro Nakayama, Kanji Ishitani, Nobuyuki Nishi, Mitsuhiro Ootsubo
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease with a high rate of mortality. It is caused by the SFTS virus (SFTSV). SFTS is endemic to western Japan, including the Kagoshima prefecture. Here, healthy persons living in Kagoshima prefecture were examined to assess the anti-SFTSV seroprevalence. An initial study was performed using serum samples collected from a total of 646 persons living in Kagoshima. At the same time, a questionnaire was used to collect information (occupation and history of being bitten by tick)...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29707799/granulocyte-antibodies-in-male-blood-donors-can-they-trigger-transfusion-related-acute-lung-injury
#12
Xuan-Duc Nguyen, Torsten J Schulze, Peter Bugert, Stephanie Lauber-Härtl, Monika Schulz-Linkholt, Karen González-Schulze, Angelika Reil, Thomas Dengler, Simon Panzer, Erhard Seifried
BACKGROUND: White blood cell-associated antibodies can lead to transfusion-related acute lung injury (TRALI). Female donors with a history of pregnancies have been identified as a main cause for these antibodies. Male or female donors without a history of pregnancy are considered as safe donors. STUDY DESIGN AND METHODS: Following the identification of two TRALI cases associated with blood products from male donors, we investigated the frequency of granulocyte-specific and human leukocyte antigen (HLA) antibodies in the entire blood donor population using a high throughput automated flow-cytometry-based granulocyte immunofluorescence test (Flow-GIFT)...
April 29, 2018: Transfusion
https://www.readbyqxmd.com/read/29707521/evaluation-by-flow-cytometry-of-mature-monocyte-subpopulations-for-the-diagnosis-and-follow-up-of-chronic-myelomonocytic-leukemia
#13
Tiphanie Picot, Carmen Mariana Aanei, Pascale Flandrin Gresta, Pauline Noyel, Sylvie Tondeur, Emmanuelle Tavernier Tardy, Denis Guyotat, Lydia Campos Catafal
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis and dysplasia in at least one myeloid cell lineage. This persistent monocytosis should be distinguished from the reactive monocytosis which is sometimes observed in a context of infections or solid tumors. In 2015, Selimoglu-Buet et al. observed an increased percentage of classical monocytes (CD14+ /CD16- >94%) in the peripheral blood (PB) of CMML patients. In this study, using multiparametric flow cytometry (MFC), we assessed the monocytic distribution in PB samples and in bone marrow aspirates from 63 patients with monocytosis or CMML suspicion, and in seven follow-up blood samples from CMML patients treated with hypomethylating agents (HMA)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29705241/hepatitis-e-blood-donor-screening-more-than-a-mere-drop-in-the-ocean
#14
Beat Mullhaupt, Christoph Niederhauser
No abstract text is available yet for this article.
April 26, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29703711/the-prevalence-of-transfusion-transmitted-infections-and-nucleic-acid-testing-among-blood-donors-in-majmaah-saudi-arabia
#15
Mohammed Alaidarous, Ranjay K Choudhary, Mohamed I Waly, Shabir Mir, Abdulaziz Bin Dukhyil, Saeed S Banawas, Bader M Alshehri
BACKGROUND: Few studies discussed the prevalence of TTIs in Saudi donor blood samples. Thus, this study investigated the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), syphilis and malaria in such samples to determine the efficacy of conducting serological and NATs on blood donors at King Khalid General Hospital in Majmaah, Saudi Arabia. METHODS: A total of 3028 donated blood units were collected from August 2015 to March 2017...
April 24, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29699477/effects-of-bacterial-translocation-on-hemodynamic-and-coagulation-parameters-during-living-donor-liver-transplant
#16
Heba A Moharem, Fawzia Aboul Fetouh, Hamed M Darwish, Doaa Ghaith, Mohamed Elayashy, Amr Hussein, Riham Elsayed, Mohammad M Khalil, Amr Abdelaal, Mahmoud ElMeteini, Ahmed Mukhtar
BACKGROUND: Bacterial translocation (BT) has been proposed as a trigger for stimulation of the immune system with consequent hemodynamic alteration in patients with liver cirrhosis. However, no information is available regarding its hemodynamic and coagulation consequences during liver transplantation. METHODS: We screened 30 consecutive adult patients undergoing living-donor liver transplant for the presence of BT. Bacterial DNA, Anti factor Xa (aFXa), thromboelastometry, tumor necrosis factor-α TNF-α, and interleukin-17 (IL-17) values were measured in sera before induction of anesthesia...
April 25, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29691150/molecular-genotyping-of-indian-blood-group-system-antigens-in-indian-blood-donors
#17
Harita Gogri, Pranali Pitale, Manisha Madkaikar, Swati Kulkarni
BACKGROUND: Haemagglutination has been the gold standard for defining the blood group status. However, these tests depend upon the availability of specific and reliable antisera. Potent antisera for extended phenotyping are very costly, weakly reacting or available in limited stocks and unavailable for some blood group systems like Indian, Dombrock, Coltan, Diego etc. The Indian blood group system consists of two antithetical antigens, Ina and Inb . The Ina /Inb polymorphism arises from 252C > G missense mutation in the CD44 gene...
April 11, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29684155/identification-of-elite-blood-donors-with-broad-and-potent-neutralizing-activity-against-the-human-cytomegalovirus
#18
Jessica Julia Falk, Martina Winkelmann, Dagmar Stöhr, Mira Alt, Hubert Schrezenmeier, Adalbert Krawczyk, Ramin Lotfi, Christian Sinzger
To improve the potency of anti-human cytomegalovirus (HCMV) immunoglobulin preparations, we intended to find elite neutralizers among 9000 HCMV-seropositive blood donors. We identified 2.6 % top neutralizers using a high throughput screening and further analyzed the 80 most effective plasmas for strain-independent activity. Of those, 58 were broadly neutralizing towards various HCMV strains and hence regarded "elite" neutralizers. All elite neutralizers were then analyzed concerning their effect on individual virus particles during entry...
April 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29675950/risk-factors-for-red-blood-cell-alloimmunization-in-the-recipient-epidemiology-and-donor-evaluation-study-reds-iii-database
#19
Matthew S Karafin, Matt Westlake, Ronald G Hauser, Christopher A Tormey, Philip J Norris, Nareg H Roubinian, Yanyun Wu, Darrell J Triulzi, Steve Kleinman, Jeanne E Hendrickson
Despite the significance of red blood cell (RBC) alloimmunization, the lack of standardized registries in the US has prevented the completion of large studies. Data from 3·5 years of the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) recipient database, containing information from 12 hospitals, were studied. A RBC alloantibody responder had an antibody identified at any point during the study, and a non-responder had a negative antibody screen at least 15 days post-RBC transfusion. Demographics, blood type, ICD9/10 codes, and other potential correlates were evaluated...
April 19, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29668135/-costs-of-chagas-disease-screening-test-in-blood-donors-in-two-colombian-blood-banks-2015
#20
Nelson José Alvis, Diana Patricia Díaz, Liliana Castillo, Nelson Rafael Alvis, María Isabel Bermúdez, Olga Maritza Berrío, Mauricio Beltrán, Carlos Andrés Castañeda-Orjuela
INTRODUCTION: Transfusion is a mechanism of transmission of Chagas' disease. There are no studies on the costs of the screening test in Colombian blood banks. OBJECTIVE: To estimate the costs of the screening test for Chagas' disease among blood donors in two Colombian blood banks, 2015. MATERIALS AND METHODS: We conducted a micro-costing study from the perspective of the health care provider to estimate the cost of Chagas' disease testing in two blood banks, Banco de Sangre de la Cruz Roja, Seccional Bolívar, and Banco de Sangre del Hospital de Yopal, Casanare, taking into account four cost categories: 1) Administrative costs: public services and insurance costs were calculated based on the blood bank area in square meters; 2) capital costs: building and equipment costs that were annualized using a 3% discount rate and a lifespan of 20 years for building and five for equipment; 3) costs of Chagas' disease test materials and reagents adjusted by blood bank production level, and 4) costs of staff in charge of Chagas' disease test processing...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
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