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https://www.readbyqxmd.com/read/28303984/silent-killers-transfusion-transmissible-infections-tti-among-asymptomatic-population-of-pakistan
#1
Muhammad Saeed, Shahida Hussain, Farhan Rasheed, Maqsood Ahmad, Mizna Arif, Muhammad Tariq Hamid Rahmani
OBJECTIVE: To analyse transfusion transmissible infections in asymptomatic population. METHODS: This study was conducted at the Allama Iqbal Medical College and Jinnah Hospital, Lahore, Pakistan, from December 2014 to November 2015, and comprised healthy asymptomatic blood donors.Every sample was screened for the presence of antibodies/antigens of hepatitis C virus, human immunodeficiency virus, treponemapallidum, hepatitis B virus and malaria parasite through rapid immunochromatographic technique...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28302713/family-cord-blood-banking-for-sickle-cell-disease-a-twenty-year-experience-in-two-dedicated-public-cord-blood-banks
#2
Hanadi Rafii, Françoise Bernaudin, Helene Rouard, Valérie Vanneaux, Annalisa Ruggeri, Marina Cavazzana, Valerie Gauthereau, Aurélie Stanislas, Malika Benkerrou, Mariane De Montalembert, Christele Ferry, Robert Girot, Cecile Arnaud, Annie Kamdem, Joelle Gour, Claudine Touboul, Audrey Cras, Mathieu Kuentz, Claire Rieux, Fernanda Volt, Barbara Cappelli, Karina T Maio, Annalisa Paviglianiti, Chantal Kenzey, Jerome Larghero, Eliane Gluckman
Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks. Participants were pregnant women who had previous child diagnosed with homozygous sickle cell disease...
March 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28299162/sero-prevalence-of-hepatitis-b-surface-antigen-amongst-pregnant-women-attending-an-antenatal-clinic-volta-region-ghana
#3
Arnold Luuse, Sylvester Dassah, Sylvester Lokpo, Louise Ameke, Mark Noagbe, Peter Adatara, Oheneba Hagan, Fred Binka
Hepatitis B virus (HBV) infection remains a global challenge, although there is currently a safe and effective vaccine available. HBV prevalence in Ghana is not well documented, but vary regionally from 4.8% to 12.3% in the general population, 10.8% to 12.7% in blood donors and about 10.6% in pregnant women. This puts Ghana among the high endemic countries in Africa. The study objective was to determine the sero-prevalence of HBs antigen (Ag) and HBeAg among pregnant women in the Ho municipality. Two hundred and eigh participants (pregnant women), attending Ho Municipal antenatal clinic were enrolled into the study...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28295355/frequency-of-trypanosoma-cruzi-parasitemia-among-infected-blood-donors-with-a-potential-association-between-parasite-lineage-and-transfusion-transmission
#4
David A Leiby, Megan L Nguyen, Melanie C Proctor, Rebecca L Townsend, Susan L Stramer
BACKGROUND: Trypanosoma cruzi is endemic to the Americas where it demonstrates multiple lineages over a vast geographic range (i.e., United States to Argentina). These lineages possess divergent geographic and biologic characteristics, including variations in disease manifestations. Herein, we report the frequency of parasitemia among seropositive US blood donors and the potential association between parasite lineage and transfusion transmission. STUDY DESIGN AND METHODS: Blood donors identified as T...
March 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28293401/alloimmunization-in-patients-with-sickle-cell-disease-and-thalassemia-experience-of-a-single-centre-in-oman
#5
Salam Alkindi, Saba AlMahrooqi, Sumaiya AlHinai, Ali AlMarhoobi, Saif Al-Hosni, Shahina Daar, Naglaa Fawaz, Anil Pathare
BACKGROUND: Blood transfusion is an integral part of the supportive care for patients with sickle cell disease (SCD) and thalassaemia. The hazard of red cell alloimmunization, however, is one of the main complications of this therapy. OBJECTIVES: The aim of this study was to evaluate the prevalence of red cell alloimmunization in Omani patients with sickle cell anaemia and thalassemia. METHODS: This study included 262 patients whose historical transfusion records were available...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28292365/serum-neopterin-a-potential-marker-for-screening-blood-donors
#6
Ahsan Ashfaq, Ayesha Ejaz, Ghazanfar Abbas
OBJECTIVE: To determine serum neopterin levels in blood donors of local population and its association with transfusion transmitted infections. STUDY DESIGN: A cross-sectional observational study. PLACE AND DURATION OF STUDY: Department of Physiology, Liaquat National Hospital and Medical College (LNHMC) in collaboration with Basic Medical Sciences Institute (BMSI) and Jinnah Postgraduate Medical Centre (JPMC), Blood Bank, Karachi, Pakistan, from January to June 2015...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28291157/deceased-organ-donors-with-a-history-of-increased-risk-behavior-for-the-transmission-of-blood-borne-viral-infection-the-uk-experience
#7
Patrick B Trotter, Dominic M Summers, Matthew Robb, William Hulme, Ines Ushiro-Lumb, Christopher J E Watson, James Neuberger, Andrew J Bradley
BACKGROUND: Deceased organ donors are routinely screened for behaviors that increase the risk of transmissible blood borne viral (BBV) infection, but the impact of this information on organ donation and transplant outcome is not well documented. Our aim was to establish the impact of such behavior on organ donation and utilization, as well transplant recipient outcomes. METHODS: We identified all UK deceased organ donors from 2003-2015 with a disclosed history of increased risk behavior (IRB) including intravenous drug use (IVDU), imprisonment and increased risk sexual behavior...
March 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28288847/increased-frequency-and-vasculogenic-potential-of-endothelial-colony-forming-cells-in-patients-with-kaposi-s-sarcoma
#8
Francesca Calcaterra, Lucia Brambilla, Elena Colombo, Athanasia Tourlaki, Stefano Veraldi, Claudia Carenza, Domenico Mavilio, Silvia Della Bella
Kaposi's sarcoma (KS) is characterized by hyperproliferation of spindle cells that have an endothelial origin and assume their characteristic features upon infection with human herpesvirus-8 (HHV8), the causative agent for KS. The multifocal nature of KS suggests that spindle cells derive from circulating HHV8-infected precursors that yet lack identification. We investigated whether ECFCs obtained from KS patients may be putative precursors of spindle cells, by assessing whether their in vitro behavior may evoke the in vivo behavior of KS spindle cells...
March 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28287381/a-preliminary-evaluation-of-next-generation-sequencing-as-a-screening-tool-for-targeted-genotyping-of-erythrocyte-and-platelet-antigens-in-blood-donors
#9
Agnieszka Orzińska, Katarzyna Guz, Michał Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Monika Pelc-Kłopotowska, Jerzy Ostrowski, Ewa Brojer
BACKGROUND: Matching the compatibility of donor blood with the recipient's antigens prevents alloimmunisation. Next-generation sequencing (NGS) technology is a promising method for extensive blood group and platelet antigen genotyping of blood donors. It circumvents the limitations of detecting known alleles based on predefined polymorphisms and enables targeted sequencing on a massive scale. The aim of this study was to evaluate the NGS AmpliSeq application on the Ion Torrent platform as a screening tool for genotyping blood donors' erythrocyte/platelet antigens...
March 10, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28285588/prevalence-and-molecular-characterization-of-canine-and-feline-hemotropic-mycoplasmas-hemoplasmas-in-northern-italy
#10
Silvia Ravagnan, Erika Carli, Eleonora Piseddu, Graziana Da Rold, Elena Porcellato, Claudia Zanardello, Antonio Carminato, Marta Vascellari, Gioia Capelli
BACKGROUND: Hemotropic mycoplasmas (hemoplasmas), the agents of infectious anemia, have been reported in dogs and cats. Little data are available on hemoplasma infections in Italy. The aim of this study was to evaluate the species of hemoplasmas and their prevalence in dogs and cats of northern Italy. METHODS: Blood samples were obtained from 117 candidate blood donor dogs, 278 free-roaming dogs and 227 free-roaming cats in 2014 and 2015. Samples were first screened for hemoplasmas with a SYBR green real time PCR...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28263168/red-blood-cell-components-time-to-revisit-the-sources-of-variability
#11
REVIEW
Rosemary L Sparrow
Quality and safety of red blood cell (RBC) components is managed by screening of donors and strict regulatory controls of blood collection, processing and storage procedures. Despite these efforts, variations in RBC component quality exist as exemplified by the wide range in storage-induced haemolysis. This article provides a brief overview of the variables that contribute or potentially contribute to the quality of stored RBC components, including blood collection, processing, and donor-related variables. Particular focus is made on donor health and lifestyle factors that are not specifically screened and may impact on the physicobiochemical properties of RBCs and their storability...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263141/use-of-blood-donor-screening-data-to-estimate-zika-virus-incidence-puerto-rico-april-august-2016
#12
Michelle S Chevalier, Brad J Biggerstaff, Sridhar V Basavaraju, M Cheryl Bañez Ocfemia, Jose O Alsina, Consuelo Climent-Peris, Robin R Moseley, Koo-Whang Chung, Brenda Rivera-García, Melissa Bello-Pagán, Lisa L Pate, Susan A Galel, Phillip Williamson, Matthew J Kuehnert
Puerto Rico has been heavily impacted by Zika virus, a mosquitoborne flavivirus that emerged in the Americas during 2015. Although most persons with Zika virus show no symptoms, the virus can cause neurologic and other complications, including fetal microcephaly. Local Zika virus transmission in Puerto Rico has been reported since December 2015. To prevent transfusion-associated transmission, local blood collection ceased in March 2016 but resumed in April 2016 after Zika virus screening of blood donations became available...
May 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28260472/anti-hla-antibody-levels-are-associated-with-the-risk-of-graft-failure-after-allogeneic-hematopoietic-stem-cell-transplant
#13
Bilkay Basturk, Mutlu Kasar, Mahmut Yeral, Miray Kavuzlu
OBJECTIVES: Allogeneic hematopoietic stem cell transplant provides a curative treatment for a considerable amount of hematologic diseases, and it is widely used today. Successful allogeneic stem cell transplant can be compromised by treatment-related toxicity, graft-versus-host disease, infectious complications, disease relapse, and graft failure. Primary graft failure is an important cause of hematopoietic stem cell transplant failure. Primary graft failure correlates with the level of complement-binding, donor-specific anti-HLA antibodies prior to transplant...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260439/kidney-swap-in-pakistan-experience-at-the-sindh-institute-of-urology-and-transplantation
#14
Naveeda Nizam, Farida Mazhar, Khawar Abbas, Tahir Aziz, Mirza Naqir Zafar, Rehan Mohsin, Bux Ali, Asad Shahzad, Mohammed Imran, Syed Adibul Hasan Rizvi
Kidney paired exchange is an established method of overcoming incompatibility in donor-recipient pairs and expanding the living-donor pool. It is infrequently performed in developing countries. We report the first kidney paired exchange in Pakistan, successfully performed at our center. One donor-recipient pair consisted of a 38-year-old female recipient (blood type, B positive) and her 40-year-old husband (A positive) as the potential donor. The second pair consisted of a 30-year-old male recipient (A positive) and his 30-year-old wife (B positive) as the potential donor...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28259182/an-unexpected-diagnosis-of-human-immunodeficiency-virus-2-infection-in-an-overseas-visitor-a-case-report
#15
Asma Sohail, Lyndal Van Leer, Natasha Holmes
BACKGROUND: Human immunodeficiency virus 2 infection is endemic in West Africa but is also found in parts of Europe, North and South America, and India where it is thought to have been introduced secondary to migration and commercial trade ties. It is less common than Human immunodeficiency virus 1, with differences in pathogenicity, lower rates of transmission, longer asymptomatic period and slower progression to acquired immunodeficiency syndrome. Human immunodeficiency virus 2 is also associated with diagnostic challenges given the lack of commercially available diagnostic tests, and management challenges given intrinsic resistance to many anti-retroviral therapies...
March 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28255771/amniotic-membrane-in-ophthalmology-properties-preparation-storage-and-indications-for-grafting-a-review
#16
REVIEW
Katerina Jirsova, Gary L A Jones
The use of amniotic membrane in ophthalmic surgery and other surgical procedures in the fields of dermatology, plastic surgery, genitourinary medicine and otolaryngology is on the increase. Furthermore, amniotic membrane and its epithelial and mesenchymal cells have broad use in regenerative medicine and hold great promise in anticancer treatment. Amniotic membrane is a rich source of biologically active factors and as such, promotes healing and acts as an effective material for wound dressing. Amniotic membrane supports epithelialization and exhibits anti-fibrotic, anti-inflammatory, anti-angiogenic and anti-microbial features...
March 2, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28252206/analysis-of-htlv-1-proviral-load-pvl-and-antibody-detected-with-various-kinds-of-tests-in-japanese-blood-donors-to-understand-the-relationship-between-pvl-and-antibody-level-and-to-gain-insights-towards-better-antibody-testing
#17
Chieko Matsumoto, Yasuko Sagara, Rieko Sobata, Yukiko Inoue, Maiko Morita, Shigeharu Uchida, Hiroyuki Kiyokawa, Masahiro Satake, Kenji Tadokoro
Adult T-cell leukemia/lymphoma (ATL) occurs in approximately 5% of individuals infected with human T-cell leukemia virus type 1 (HTLV-1). A high proviral load (PVL; more than 4 copies per 100 peripheral blood mononuclear cells (PBMCs) or 1.6 copies per 100 blood leukocytes) and being male are risk factors for ATL development. Whether anti-HTLV-1 antibody level is related to such risk is unknown. Here, PVL and antibody levels were examined using real-time PCR and other tests in 600 HTLV-1 positive screened Japanese blood donors to understand the relationship between PVL and antibody level in asymptomatic carriers and to gain insights towards better antibody testing for HTLV-1 infection...
March 2, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28244600/a-mathematical-model-for-estimating-residual-transmission-risk-of-occult-hepatitis-b-virus-infection-with-different-blood-safety-scenarios
#18
Jos Weusten, Harry van Drimmelen, Marion Vermeulen, Nico Lelie
BACKGROUND: If anti-hepatitis B core antibody testing is not mandated blood donors with occult hepatitis B infection (OBI) may transmit hepatitis B virus (HBV) to a recipient in spite of the use of nucleic acid amplification technology (NAT) or pathogen inactivation (PI). STUDY DESIGN AND METHODS: We developed a model to estimate OBI transmission risk based on three components: the probability distribution of the viral load (VL) in a randomly selected OBI donor, the probability that a given VL remains undetected, and the probability that this VL causes infection in the recipient...
February 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28231025/rabit-ii-implementation-of-a-high-throughput-micronucleus-biodosimetry-assay-on-commercial-biotech-robotic-systems
#19
Mikhail Repin, Sergey Pampou, Charles Karan, David J Brenner, Guy Garty
We demonstrate the use of high-throughput biodosimetry platforms based on commercial high-throughput/high-content screening robotic systems. The cytokinesis-block micronucleus (CBMN) assay, using only 20 μl whole blood from a fingerstick, was implemented on a PerkinElmer cell::explorer and General Electric IN Cell Analyzer 2000. On average 500 binucleated cells per sample were detected by our FluorQuantMN software. A calibration curve was generated in the radiation dose range up to 5.0 Gy using the data from 8 donors and 48,083 binucleated cells in total...
February 23, 2017: Radiation Research
https://www.readbyqxmd.com/read/28230309/evaluation-of-positive-and-false-positive-results-in-syphilis-screening-of-blood-donors-in-rio-de-janeiro-brazil
#20
V S Sandes, S G C Silva, I J F Motta, L G C Velarde, S R de Castilho
OBJECTIVES: We propose to analyse the positive and false-positive results of treponemal and nontreponemal tests in blood donors from Brazil and to evaluate possible factors associated with the results of treponemal tests. BACKGROUND: Treponemal tests have been used widely for syphilis screening in blood banks. The introduction of these tests in donor screening has caused an impact and a loss of donors who need to be assessed. METHODS: This was a retrospective cross-sectional study of syphilis screening and confirmatory test results of blood donors that were obtained before and after adopting a chemiluminescent immunoassay (CLIA)...
February 23, 2017: Transfusion Medicine
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