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Puberty precocis

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https://www.readbyqxmd.com/read/28926827/one-year-follow-up-of-girls-with-precocious-puberty-and-their-mothers-do-psychological-assessments-change-over-time-or-with-treatment
#1
Melissa J Schoelwer, Kelly L Donahue, Paula Didrick, Erica A Eugster
BACKGROUND: To determine whether psychological characteristics of girls with variations of early puberty and their mothers change over time and with treatment in girls with central precocious puberty (CPP). METHODS: Girls with CPP, premature adrenarche (PA), and early normal puberty (ENP) completed psychological assessments at baseline and after 1 year along with their mothers. All girls with CPP were treated with GnRH analogs. Psychological effects of group and time were examined using 2 × 3 mixed ANOVAs...
September 19, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28919976/impacts-of-prenatal-nutrition-on-animal-production-and-performance-a-focus-on-growth-and-metabolic-and-endocrine-function-in-sheep
#2
REVIEW
Prabhat Khanal, Mette Olaf Nielsen
The concept of foetal programming (FP) originated from human epidemiological studies, where foetal life nutrition was linked to health and disease status later in life. Since the proposal of this phenomenon, it has been evaluated in various animal models to gain further insights into the mechanisms underlying the foetal origins of health and disease in humans. In FP research, the sheep has been quite extensively used as a model for humans. In this paper we will review findings mainly from our Copenhagen sheep model, on the implications of late gestation malnutrition for growth, development, and metabolic and endocrine functions later in life, and discuss how these implications may depend on the diet fed to the animal in early postnatal life...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28919321/clinicopathological-pattern-and-outcome-of-pediatric-malignant-ovarian-germ-cell-tumors-south-egypt-cancer-institute-experience
#3
Amany Ali, Heba Sayed, Mohamed Salem, Mohamed Hamdy, Amro Farok
BACKGROUND: Malignant ovarian germ cell tumors (MOGCTs) are rare and represent 1-1.5% of all cancers in children and adolescents. The aim of this study is to analyze the clinicopathological pattern at presentation and management and outcome of MOGCTs in children and adolescents. PATIENTS AND METHODS: Retrospective study included all girls diagnosed with MOGCTs between January 2005 and January 2015 in Pediatric and Surgical Oncology Departments at South Egypt Cancer Institute, Assiut University...
September 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28899882/chromosome-15-structural-abnormalities-effect-on-igf1r-gene-expression-and-function
#4
Rossella Cannarella, Teresa Mattina, Rosita A Condorelli, Laura M Mongioì, Giuseppe Pandini, Sandro La Vignera, Aldo E Calogero
Insulin-like growth factor 1 receptor (IGF1R), mapping on the 15q26.3 chromosome, is required for normal embryonic and postnatal growth. The aim of the present study was to evaluate the IGF1R gene expression and function in three unrelated patients with chromosome 15 structural abnormalities. We report two male patients with the smallest 15q26.3 chromosome duplication described so far, and a female patient with ring chromosome 15 syndrome. Patient one, with a 568 kb pure duplication, had overgrowth, developmental delay, mental and psychomotor retardation, obesity, cryptorchidism, borderline low testis volume, severe oligoasthenoteratozoospermia and gynecomastia...
October 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28894189/hypo-hydroxymethylation-of-rrna-genes-in-the-precocious-eriocheir-sinensis-testes-revealed-using-hmedip-seq
#5
Genliang Li, Hui Qian
Precocious puberty is a common phenomenon in crab breeding that seriously reduces the economic benefits for crab farmers. To address this problem, this study aimed to explore the potential functions of both methylation and hydroxymethylation of testis rRNA genes with respect to precocious puberty in Eriocheir sinensis. The results showed that the rRNA genes in normally developing testes of E. sinensis had low levels of methylation and high levels of hydroxymethylation; however, although methylation levels were similar, the level of hydroxymethylation in precocious testes was lower than normal...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891963/the-effect-of-bisphenol-a-on-puberty-a-critical-review-of-the-medical-literature
#6
REVIEW
Alberto Leonardi, Marta Cofini, Donato Rigante, Laura Lucchetti, Clelia Cipolla, Laura Penta, Susanna Esposito
Many scientific studies have revealed a trend towards an earlier onset of puberty and have disclosed an increasing number of children that display precocious puberty. As an explanation, some authors have considered the global socio-economic improvement across different populations, and other authors have considered the action of endocrine disrupting chemicals (EDCs). Among these, bisphenol A (BPA), an aromatic compound largely used worldwide as a precursor of some plastics and chemical additives, is well known for its molecular oestrogen-like and obesogenic actions...
September 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28890442/marked-geographic-patterns-in-the-incidence-of-idiopathic-central-precocious-puberty-a-nationwide-study-in-france
#7
Joëlle Le Moal, Annabel Rigou, Alain Le Tertre, Perrine Decrouy-Chanel, Juliane Leger, Jean-Claude Carel
OBJECTIVES: Precocious puberty seems to be increasing but epidemiological data are scarce. Our objective was to improve the epidemiologic knowledge on this disease, in the context of a suspected role of endocrine disruptor chemicals exposure. We analyzed the national incidence and spatial trends of idiopathic central precocious puberty in France in 2011-2013 in a cross-sectional descriptive study. DESIGN: We used an indicator based on treatment reimbursements recorded in the national insurance database, in boys less than 10 years and girls less than nine years old...
September 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28888750/primary-mediastinal-pure-seminomatous-germ-cell-tumor-germinoma-as-a-rare-cause-of-precocious-puberty-in-a-9-year-old-patient
#8
Alejandra Bravo-Balado, Lynda Torres Castellanos, Adriana Carrillo Rodríguez, Daniel Gómez Zapata, Juan Javier Lammoglia Hoyos, Rafael Andrade, Jaime Pérez Niño
Less than 5-7% of germ cell tumors (GCTs) are extragonadal, being the central nervous system (CNS) the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one third of these are pure seminomas (germinomas). We report the case of a 9 year-old boy with development of secondary sexual characteristics. Beta human chorionic gonadotropin (B-hCG) was elevated and a mediastinal mass was found. Final histology showed a pure seminomatous germ cell tumor (SGCT)...
September 6, 2017: Urology
https://www.readbyqxmd.com/read/28878739/precocious-puberty-or-premature-thelarche-analysis-of-a-large-patient-series-in-a-single-tertiary-center-with-special-emphasis-on-6-to-8-year-old-girls
#9
Tero Varimo, Heta Huttunen, Päivi Johanna Miettinen, Laura Kariola, Johanna Hietamäki, Annika Tarkkanen, Matti Hero, Taneli Raivio
INTRODUCTION: We describe the etiology, MRI findings, and growth patterns in girls who had presented with signs of precocious puberty (PP), i.e., premature breast development or early menarche. Special attention was paid to the diagnostic findings in 6- to 8-year-olds. MATERIALS AND METHODS: We reviewed the medical records of 149 girls (aged 0.7-10.3 years) who had been evaluated for PP in the Helsinki University Hospital between 2001 and 2014. RESULTS: In 6- to 8-year-old girls, PP was most frequently caused by idiopathic gonadotropin-releasing hormone (GnRH)-dependent PP (60%) and premature thelarche (PT; 39%)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28866322/advanced-bone-age-as-an-indicator-facilitates-the-diagnosis-of-precocious-puberty
#10
Yue-Qin Xu, Gui-Mei Li, Yan Li
OBJECTIVE: Diagnosis of central precocious puberty (CPP) has always been challenging in clinical practice. As an important method in the diagnosis of CPP, luteinizing hormone-releasing hormone (LHRH) stimulation test is complex and time-consuming. In many cases, clinical traits are inconsistent with LHRH stimulation test results, therefore not reliable for diagnosis. In this study, the authors intended to find an indicator that predicts the results of the LHRH stimulation test among subjects with early pubertal signs...
August 30, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28859283/plasma-anti-m%C3%A3-llerian-hormone-profile-in-heifers-from-birth-through-puberty-and-relationship-with-puberty-onset
#11
Hossam El-Sheikh Ali, Go Kitahara, Toru Takahashi, Shogo Mido, Mohammed Sadawy, Ikuo Kobayashi, Koichiro Hemmi, Takeshi Osawa
The current study aimed to define the plasma profile of anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH) in heifers during postnatal life until achieving puberty, as defined by plasma progesterone (P4) profile, to demonstrate a relationship between AMH and age of puberty onset. Blood samples collected from 11 Japanese Black female calves within 1 week after birth (W 0) and then biweekly until the sixth week after puberty (WP 6) were assayed for AMH, FSH, and P4. The heifers were classified into two groups based on age of puberty onset: ≤42 weeks (early puberty group; EP, n = 4) and ≥44 weeks (late puberty group; LP, n = 7)...
July 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28854950/prevalence-and-risk-factors-for-type-2-diabetes-mellitus-with-prader-willi-syndrome-a-single-center-experience
#12
Aram Yang, Jinsup Kim, Sung Yoon Cho, Dong-Kyu Jin
BACKGROUND: Prader-Willi syndrome (PWS) is often related to severe obesity and type-2 diabetes mellitus (T2DM). However, few studies, and none in Korea, have examined prevalence of T2DM and other variables in PWS. The aim of this study was to identify the prevalence and associated risk factors for T2DM in Korean patients with PWS. METHODS: We performed a retrospective cohort study of the 84 PWS patients aged 10 or over (10.3-35.8 years of age) diagnosed with PWS at Samsung Medical Center from 1994 to 2016...
August 30, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28845837/mazabraud-syndrome-associated-with-mccune-albright-syndrome-a-case-report-and-review-of-the-literature
#13
Alessio Biazzo, Andrea Di Bernardo, Antonina Parafioriti, Norberto Confalonieri
Mazabraud syndrome is a very rare benign disorder characterized by the association of monostotic or polyostotic fibrous dysplasia and one or multiple intramuscular myxomas. McCune -Albright syndrome is a rare benign disorder characterized by the association of polyostotic fibrous dysplasia, cafè-au-lait skin pigmentations and endocrine dysfunction, such as precocious puberty, diabetes mellitus, goiter and breast fibroadenomatosis. The association of Mazabraud syndrome and McCune-Albright in the same patient is an anecdotal event...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28791667/prevalence-of-vitamin-d-deficiency-in-girls-with-idiopathic-central-precocious-puberty
#14
Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors...
August 8, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28791047/central-precocious-puberty-and-response-to-gnrha-therapy-in-children-with-cerebral-palsy-and-moderate-to-severe-motor-impairment-data-from-a-longitudinal-case-control-multicentre-italian-study
#15
Patrizia Bruzzi, Maria Francesca Messina, Alessandra Bartoli, Barbara Predieri, Laura Lucaccioni, Simona Filomena Madeo, Alberto Verrotti, Filippo De Luca, Lorenzo Iughetti
BACKGROUND: Children affected by neurodevelopmental disability could experience early pubertal changes at least 20 times more than the general population. Limited data about central precocious puberty (CPP) among children affected by cerebral palsy (CP) are available. METHODS: This is a longitudinal, observational, retrospective, case-control study involving 22 children affected by CPP and CP (group A), 22 paired with CP but without CPP (group B), and 22 children with CPP without CP...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28748008/-precocious-puberty-in-a-little-girl-revealing-malignant-corticosurrenaloma
#16
Ayad Anass, Amina Kili
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28742520/growth-and-pubertal-patterns-in-young-survivors-of-childhood-acute-lymphoblastic-leukemia
#17
Sarah Elitzur, Revital Houri-Shtrecher, Michal Yackobovitz-Gavan, Galia Avrahami, Shlomit Barzilai, Gil Gilad, Yael Lebenthal, Moshe Phillip, Batia Stark, Isaac Yaniv, Shlomit Shalitin
BACKGROUND: Survivors of acute lymphoblastic leukemia (ALL) may experience endocrine dysfunction. This study evaluated growth and pubertal patterns in survivors of childhood ALL. METHODS: Longitudinal assessment of anthropometric measurements and pubertal status was performed in a retrospective cohort of survivors (n=183). Median age at last endocrine visit was 16.1 years (range 8.2-27.6); median follow-up time was 8.7 years (range 3-21.4). RESULTS: Treatment with chemotherapy+prophylactic cranial radiation (pCRT, n=29) was associated with lower mean height standard deviation score (SDS) than chemotherapy alone (n=154) (p=0...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28739555/serum-nesfatin-1-levels-in-girls-with-idiopathic-central-precocious-puberty
#18
Ayça Altıncık, Oya Sayın
OBJECTIVE: Nesfatin-1, which is defined as an anorexigenic neuropeptide, is expressed mainly in central nervous system and in some periferic tissues. The role of nesfatin-1 in energy balance has been investigated; however, data are limited on the role of nesfatin-1 in human puberty. METHODS: The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty; and ii) relationship between nesfatin-1 and anthropometric measures, gonadotropin levels in girls with idiopathic central precocious puberty (CPP)...
July 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28721217/an-fsh-and-tsh-pituitary-adenoma-presenting-with-precocious-puberty-and-central-hyperthyroidism
#19
Guadalupe Vargas, Lourdes-Josefina Balcazar-Hernandez, Virgilio Melgar, Roser-Montserrat Magriña-Mercado, Baldomero Gonzalez, Javier Baquera, Moisés Mercado
A 19-year-old woman with a history of isosexual precocious puberty and bilateral oophorectomy at age 10 years because of giant ovarian cysts, presents with headaches and mild symptoms and signs of hyperthyroidism. Hormonal evaluation revealed elevated FSH and LH levels in the postmenopausal range and free hyperthyroxinemia with an inappropriately normal TSH. Pituitary MRI showed a 2-cm macroadenoma with suprasellar extension. She underwent successful surgical resection of the pituitary tumor, which proved to be composed of two distinct populations of cells, each of them strongly immunoreactive for FSH and TSH, respectively...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28697822/-diagnostic-value-of-baseline-serum-luteinizing-hormone-level-for-central-precocious-puberty-in-girls
#20
Li-Xue Ou-Yang, Fan Yang
OBJECTIVE: To evaluate the diagnostic value of baseline serum luteinizing hormone (LH) level for central precocious puberty (CPP) in girls. METHODS: A total of 279 girls with precocious puberty were subjected to assessment of growth and development, bone age determination, baseline LH test, and follicle-stimulating hormone (FSH) test, gonadotropin-releasing hormone stimulation test, and other related examinations. Of the 279 patients, 175 were diagnosed with CPP and 104 with premature thelarche (PT)...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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