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https://www.readbyqxmd.com/read/28543857/vena-cava-responsiveness-to-controlled-isovolumetric-respiratory-efforts
#1
Anna Folino, Marco Benzo, Paolo Pasquero, Andrea Laguzzi, Luca Mesin, Alessandro Messere, Massimo Porta, Silvestro Roatta
OBJECTIVES: Respirophasic variation of inferior vena cava (IVC) size is affected by large variability with spontaneous breathing. This study aims at characterizing the dependence of IVC size on controlled changes in intrathoracic pressure. METHODS: Ten healthy subjects, in supine position, performed controlled isovolumetric respiratory efforts at functional residual capacity, attaining positive (5, 10, and 15 mmHg) and negative (-5, -10, and -15 mmHg) alveolar pressure levels...
May 22, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28536534/a-bio-realistic-finite-element-model-to-evaluate-the-effect-of-masticatory-loadings-on-mouse-mandible-related-tissues
#2
Alexander Tsouknidas, Lucia Jimenez-Rojo, Evangelos Karatsis, Nikolaos Michailidis, Thimios A Mitsiadis
Mice are arguably the dominant model organisms for studies investigating the effect of genetic traits on the pathways to mammalian skull and teeth development, thus being integral in exploring craniofacial and dental evolution. The aim of this study is to analyse the functional significance of masticatory loads on the mouse mandible and identify critical stress accumulations that could trigger phenotypic and/or growth alterations in mandible-related structures. To achieve this, a 3D model of mouse skulls was reconstructed based on Micro Computed Tomography measurements...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28535995/inflammation-associated-gene-expression-in-raw-264-7-macrophages-induced-by-toxins-from-fungi-common-on-damp-building-materials
#3
Thomas G Rand, Carolyn T Chang, David R McMullin, J David Miller
Most fungi that grow on damp building materials produce low molecular weight compounds, some of which are known to be toxic. In this study, we tested the hypothesis that exposure to some metabolites of fungi common on damp building materials would result in time-, dose-, and compound-specific responses in the production of various chemokines by RAW 264.7 cells. Cell cultures were exposed to a 10(-7)M or 10(-8)M metabolite dose for 2, 4, 12 or 24h. Metabolite concentrations used were based on those that might be expected in alveolar macrophages due to inhalation exposure from living or working in a damp building...
May 20, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28529749/chondroblastic-osteosarcoma-arising-in-the-maxilla-mimicking-the-radiographic-and-histological-characteristics-of-cemento-osseous-lesions-a-case-report
#4
Bin-Bin Li, Jian-Yun Zhang, Yan Gao
Osteosarcomas of the jaw are comparatively rare and represent only 2-10% of all osteosarcomas. We herein present a rare case of an osteosarcoma exhibiting the radiographic and histological characteristics of cemento-osseous lesions in the alveolar ridge of the maxilla. A 53-year-old male patient presented with the complaint of gradual swelling of the left maxilla over 4 years. Radiography revealed an ill-defined radioopaque mass, intimately associated with the apices of the involved teeth, without a periosteal reaction...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28523329/respiratory-bronchiolitis-associated-interstitial-lung-disease-an-unexpected-form-of-idiopathic-interstitial-pneumonia-in-a-young-male
#5
Claudia Lucia Toma, Elena Danteş, Diana Gabriela Leonte, Ariadna Petronela Fildan
Cigarette smoking is the most frequently encountered risk factor for chronic obstructive pulmonary disease and lung cancer. The latest American Thoracic Society÷European Respiratory Society classification of idiopathic interstitial pneumonia includes two entities related to smoking habits: respiratory bronchiolitis-associated interstitial lung disease and desquamative interstitial pneumonia. The new approach to diagnosis is to combine pathological pattern with clinical and radiological data. Lung biopsy is no longer considered the "gold standard" for diagnosis, but as a part of the diagnosis, which shall be set only after the pulmonologist, radiologist and pathologist reviewed all clinical, imaging and pathological aspects...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28512413/two-cases-of-nivolumab-re-administration-after-pneumonitis-as-immune-related-adverse-events
#6
Keisuke Imafuku, Koji Yoshino, Kei Yamaguchi, Satoshi Tsuboi, Kuniaki Ohara, Hiroo Hata
Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis, hepatitis, dermatitis, and thyroiditis. Prednisolone can effectively treat irAEs. However, it is unclear how or if nivolumab should be administered to patients after they have experienced an irAE. Herein, we show 2 patients who underwent pneumonitis as irAE. Case 1 demonstrated a cryptogenic organizing pneumonia pattern in the CT scan and case 2 had a diffuse alveolar damage (DAD) pattern...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28507378/case-series-of-rare-interstitial-lung-disease-ild
#7
Naveed Haroon Rashid, Saba Farooq, Mohammad Ahmed, Ali Bin Sarwar Zubairi
Pulmonary alveolar proteinosis (PAP) is a rare lung disease where periodic acid Schiff (PAS)-positive eosinophilic material accumulates in the alveoli of the lungs. Here we describe two cases of young males who presented with dynpnoea and weight loss. The HRCT scan of the chest in both cases showed the typical "crazy-paving" pattern and lung biopsies confirmed the diagnosis of PAP. They showed remarkable symptomatic improvement with therapeutic whole lung lavage.
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28507352/candidiasis-prevalence-and-resistance-profiling-in-a-tertiary-care-hospital-of-pakistan
#8
Bushra Jamil, Mohammad Tauseef Mukhtar Bokhari, Azhar Saeed, Mohammad Zahid Mukhtar Bokhari, Zakir Hussain, Tayyaba Khalid, Habib Bokhari, Mohammad Imran, Shahid Ahmad Abbasi
OBJECTIVE: To determine Candida colonisation/infection in renal transplant patients and to determine the resistance pattern against antifungal drugs. METHODS: This prospective, observational study was conducted at Al-Sayyed Hospital, Rawalpindi, Pakistan, from January to October 2014, in collaboration with the Microbiology and Public Health Laboratory's, Islamabad campus..The clinical specimens investigated included respiratory tract secretions, blood, urine, high vaginal swab, skin scrapings, and plastic devices samples...
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28489415/hepatic-steatosis-accompanies-pulmonary-alveolar-proteinosis
#9
Alan N Hunt, Anagha Malur, Tual Monfort, Pavlos Lagoudakis, Sumeet Mahajan, Anthony D Postle, Mary Jane Thomassen
Maintenance of tissue-specific organ lipid compositions characterises mammalian lipid homeostasis. Lung and liver synthesise mixed phosphatidylcholine (PC) molecular species subsequently "tailored" for function. Lungs progressively enrich disaturated PC (DSPC) directed to lamellar body (LB) surfactant stores prior to secretion. Liver accumulates polyunsaturated PC directed to VLDL assembly and secretion, or triglyceride stores. In each tissue, selective PC species enrichment mechanisms lie at the heart of effective homeostasis...
May 10, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28487307/aripiprazole-induced-hypersensitivity-pneumonitis
#10
Kulothungan Gunasekaran, Swetha Murthi, Jeffrey Jennings, Nazir Lone
Aripiprazole is an atypical antipsychotic agent commonly used in the management of schizophrenia. Aripiprazole has not been reported to have an association with interstitial lung disease. We describe a case of a 36-year-old woman who began to experience respiratory issues shortly after starting aripiprazole and presented to us 4 years later with progressive exertional shortness of breath. High-resolution CT of the chest showed a bilateral ground glass pattern. Video-assisted thoracoscopy with biopsy revealed alveolar septal thickening and an inflammatory infiltrate composed mainly of lymphocytes, suggestive of chronic hypersensitivity pneumonitis...
May 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28485753/morphometric-study-of-the-mylohyoid-bridging-in-dry-mandibles
#11
Silviya Y Nikolova, Diana H Toneva, Yordan A Yordanov, Nikolai E Lazarov
The mylohyoid bridging is a hyperostotic variation representing formation of bony bridges over the mylohyoid groove. The goals of this study were to establish the frequency of mylohyoid bridging in contemporary and medieval series from Bulgaria and to examine the changes in the prevalence through time, to assess and compare the different types of mylohyoid bridging, to establish the patterns of distribution with respect to laterality, sex and age and to accomplish a morphometric analysis. Materials and methods: The study was performed on a total of 448 intact dry mandibles of adult individuals from both sexes, grouped into contemporary male, medieval male and medieval female series from Bulgaria...
May 8, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28484089/xenogeneic-human-umbilical-cord-derived-mesenchymal-stem-cells-reduce-mortality-in-rats-with-acute-respiratory-distress-syndrome-complicated-by-sepsis
#12
Fan-Yen Lee, Kuan-Hung Chen, Christopher Glenn Wallace, Pei-Hsun Sung, Jiunn-Jye Sheu, Sheng-Ying Chung, Yung-Lung Chen, Hung-I Lu, Sheung-Fat Ko, Cheuk-Kwan Sun, Hsin-Ju Chiang, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
This study tested the hypothesis that xenogeneic human umbilical cord-derived mesenchymal stem cell (HUCDMSC) therapy would improve survival rates in rats with acute respiratory distress-syndrome (ARDS, induction by 48 h inhalation of 100% oxygen) and sepsis-syndrome (SS, induction by cecal-ligation and puncture) (ARDS-SS). Adult-male Sprague-Dawley rats were categorized into group 1 (sham-controls), group 2 (ARDS-SS), group 3 [ARDS-SS+HUCDMSC (1.2 x106 cells administered 1 h after SS-induction)], and group 4 [ARDS-SS+HUCDMSC (1...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28483274/predictive-factors-for-alveolar-fenestration-and-dehiscence
#13
A-M Grimoud, V E Gibbon, I Ribot
The purpose of this study was to evaluate the distribution and incidence of two forms of alveolar bone resorption known as fenestration and dehiscence across time and space. To accomplish this a Medieval French population was studied and the results were compared with other studies to examine incidence and distribution of alveolar bone resorption. Thus, 1175 teeth were analysed for 81 individuals, from an agropastoral Medieval (12th-14th century) archaeological site of Vilarnau located in the South of France...
March 22, 2017: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/28470471/expression-and-activity-of-breast-cancer-resistance-protein-bcrp-abcg2-in-human-distal-lung-epithelial-cells-in-vitro
#14
Sabrina Nickel, Mohammed Ali Selo, Juliane Fallack, Caoimhe G Clerkin, Hanno Huwer, Nicole Schneider-Daum, Claus-Michael Lehr, Carsten Ehrhardt
PURPOSE: Breast cancer resistance protein (BCRP/ABCG2) has previously been identified with high expression levels in human lung. The subcellular localisation and functional activity of the transporter in lung epithelia, however, remains poorly investigated. The aim of this project was to study BCRP expression and activity in freshly isolated human alveolar epithelial type 2 (AT2) and type 1-like (AT1-like) cells in primary culture, and to compare these findings with data obtained from the NCI-H441 cell line...
May 3, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28469930/early-extracellular-matrix-changes-are-associated-with-later-development-of-bronchiolitis-obliterans-syndrome-after-lung-transplantation
#15
Catharina Müller, Annika Andersson-Sjöland, Hans Henrik Schultz, Leif T Eriksson, Claus B Andersen, Martin Iversen, Gunilla Westergren-Thorsson
BACKGROUND: Chronic lung allograft dysfunction in the form of bronchiolitis obliterans syndrome (BOS) is the main cause of death beyond 1-year post-lung transplantation. The disease-initiating triggers as well as the molecular changes leading to fibrotic alterations in the transplanted lung are largely unknown. The aim of this study was to identify potential early changes in the extracellular matrix (ECM) in different compartments of the transplanted lung prior to the development of BOS...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28469724/simultaneous-presentation-of-two-noninflammatory-lung-diseases-in-an-hiv-infected-patient
#16
Rafael Martínez-Girón, Santiago Martínez-Torre
The simultaneous presentation of two noninflammatory pulmonary diseases, pulmonary alveolar proteinosis and Kaposi's sarcoma (Ks), in an HIV-infected patient, is described. A 29-year-old black race patient was admitted to the hospital because of general malaise, weight loss, dyspnea, chest pain, and cough with hemoptoic expectoration. Chest X-rays revealed a patchy bilateral alveolar pattern with a tendency toward the formation of condensations. The serological test revealed HIV positivity (CD4 counts of 393 cells/mm(3))...
April 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28467885/diving-and-pulmonary-physiology-surfactant-binding-protein-lung-fluid-and-cardiopulmonary-test-changes-in-professional-divers
#17
Zora Susilovic-Grabovac, Cristina Banfi, Denise Brusoni, Massimo Mapelli, Stefania Ghilardi, Ante Obad, Darija Bakovic-Kramaric, Zeljko Dujic, Piergiuseppe Agostoni
Alteration of breathing pattern ranging from an increase of respiratory rate to overt hyperventilation during and after SCUBA diving is frequently reported and is associated with intrathoracic fluid overload. This study was undertaken to assess breathing efficiency after diving and the association with damage of alveolar cells. Ventilation efficiency (VE/VCO2) during maximal cardiopulmonary exercise test (CPET) before and 2h after a standard protocol dive has been analyzed in twelve professional males divers (39...
April 30, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28464801/surfactant-protein-d-predicts-prognosis-of-interstitial-lung-disease-induced-by-anticancer-agents-in-advanced-lung-cancer-a-case-control-study
#18
Kota Nakamura, Motoyasu Kato, Takehito Shukuya, Keita Mori, Yasuhito Sekimoto, Hiroaki Ihara, Ryota Kanemaru, Ryo Ko, Rina Shibayama, Ken Tajima, Ryo Koyama, Naoko Shimada, Osamu Nagashima, Fumiyuki Takahashi, Shinichi Sasaki, Kazuhisa Takahashi
BACKGROUND: Interstitial lung diseases induced by anticancer agents (ILD-AA) are rare adverse effects of anticancer therapy. However, prognostic biomarkers for ILD-AA have not been identified in patients with advanced lung cancer. Our aim was to analyze the association between serum biomarkers sialylated carbohydrate antigen Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D), and clinical characteristics in patients diagnosed with ILD-AA. METHODS: Between April 2011 and March 2016, 1224 advanced lung cancer patients received cytotoxic agents and epidermal growth factor receptor tyrosine kinase inhibitors at Juntendo University Hospital and Juntendo University Urayasu Hospital...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28457418/histopathological-findings-associated-with-gastroesophageal-reflux-disease-and-aspiration-after-lung-transplantation-initial-brazilian-single-center-experience
#19
R M Carraro, E C T Nascimento, S Szachnowicz, P C L B Camargo, S V Campos, J E Afonso, M N Samano, P M Pêgo-Fernandes, M Dolhnikoff, R H O B Teixeiraa, A N Costa
BACKGROUND: Gastro-esophageal reflux disease (GERD) and broncho-aspiration (BA) are known to increase the risk for chronic lung allograft dysfunction (CLAD). However, specific lung injury mechanisms are not clearly known. The objective of the study was to describe histopathological findings in surveillance lung transbronchial biopsies that can be correlated with episodes of BA in the lung allograft. METHODS: This retrospective analysis of surveillance transbronchial biopsies was performed in lung transplant recipients, with available data of broncho-alveolar fluid (cultures and cytology), lung function parameters, and esophageal functional tests...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28449608/primary-pulmonary-myxoid-sarcoma-a-newly-described-entity-report-of-a-case-and-review-of-the-literature
#20
Carlos N Prieto-Granada, Rose B Ganim, Lei Zhang, Cristina Antonescu, James Mueller
Primary pulmonary myxoid sarcoma (PPMS) is a recently described, exceedingly rare low-grade lung sarcoma that tends to present in young females as an endobronchial mass and shows evidence of an EWSR1- CREB1 fusion. Herein, we present a case of PPMS with fluorescence in situ hybridization (FISH) analysis for EWSR1 and CREB1 rearrangements. An 80-year-old woman presented with an endobronchial, multinodular tumor exhibiting spindle, ovoid and epithelioid cells arranged in reticular/lattice-like and alveolar-like patterns in a myxoid background...
April 1, 2017: International Journal of Surgical Pathology
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