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S100B in children

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https://www.readbyqxmd.com/read/28612133/brain-specific-serum-biomarkers-predict-neurological-morbidity-in-diagnostically-diverse-pediatric-intensive-care-unit-patients
#1
Alicia K Au, Michael J Bell, Ericka L Fink, Rajesh K Aneja, Patrick M Kochanek, Robert S B Clark
BACKGROUND: Unexpected neurological morbidity in Pediatric Intensive Care Units (PICUs) remains high and is difficult to detect proactively. Brain-specific biomarkers represent a novel approach for early detection of neurological injury. We sought to determine whether serum concentrations of neuron-specific enolase (NSE), myelin basic protein (MBP), and S100B, specific for neurons, oligodendrocytes, and glia, respectively, were predictive of neurological morbidity in critically ill children...
June 13, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28605426/biomarkers-of-cerebral-injury-and-inflammation-in-pediatric-tuberculous-meningitis
#2
Ursula K Rohlwink, Katya Mauff, Katalin A Wilkinson, Nico Enslin, Emmanuel Wegoye, Robert J Wilkinson, Anthony A Figaji
Background: Tuberculous meningitis (TBM) leads to death or disability in half the affected individuals. Tools to assess severity and predict outcome are lacking. Neuro-specific biomarkers could serve as markers of the severity and evolution of brain injury, but have not been widely explored in TBM. We examined biomarkers of neurological injury (neuromarkers) and inflammation in pediatric TBM and their association with outcome. Methods: Blood and cerebrospinal fluid (CSF) of children with TBM and hydrocephalus taken on admission and over 3 weeks were analysed for neuromarkers S100B, neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP), and multiple inflammatory markers...
June 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28439892/cerebrospinal-fluid-cyto-chemokine-profile-during-acute-herpes-simplex-virus-induced-anti-n-methyl-d-aspartate-receptor-encephalitis-and-in-chronic-neurological-sequelae
#3
Kavitha Kothur, Deepak Gill, Melanie Wong, Shekeeb S Mohammad, Sushil Bandodkar, Susan Arbunckle, Louise Wienholt, Russell C Dale
AIM: To examine the cytokine/chemokine profile of cerebrospinal fluid (CSF) during acute herpes simplex virus-induced N-methyl-d-aspartate receptor (NMDAR) autoimmunity and in chronic/relapsing post-herpes simplex virus encephalitis (HSE) neurological syndromes. METHOD: We measured longitudinal serial CSF cyto-/chemokines (n=34) and a glial marker (calcium-binding astroglial protein, S100B) in one patient during acute HSE and subsequent anti-NMDAR encephalitis, and compared the results with those from two patients with anti-NMDAR encephalitis without preceding HSE...
April 25, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28202117/-value-of-serum-s100b-protein-and-neuron-specific-enolase-levels-in-predicting-the-severity-of-hand-foot-and-mouth-disease
#4
Jing Li, Rui-Hai Liu, Ruo-Bing Shan
OBJECTIVE: To study the value of serum S100B protein and neuron-specific enolase (NSE) levels in predicting the severity of hand, foot and mouth disease (HFMD). METHODS: Ninety children with HFMD were classified into three groups: common type, severe type, and critical type (n=30 each). Thirty healthy children were randomly selected as the control group. ELISA was used to measure serum levels of S100B protein and NSE before and at 7 days after treatment. The receiver operating characteristic (ROC) curve was used to evaluate the prediction efficiency of S100B protein and NSE for the severity of HFMD...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099628/elevated-plasma-concentrations-of-s100-calcium-binding-protein-b-and-tumor-necrosis-factor-alpha-in-children-with-autism-spectrum-disorders
#5
Selin Aktan Guloksuz, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F Leckman
Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28027282/role-of-rifampin-in-reducing-inflammation-and-neuronal-damage-in-childhood-bacterial-meningitis-a-pilot-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Lipi Uppal, Sunit Singhi, Pratibha Singhi, Ritu Aggarwal
BACKGROUND: Treatment of acute bacterial meningitis in children with bactericidal antibiotics causes cell wall lysis and a surge in inflammatory cascade, which in turn contributes to neuronal damage and morbidity. Pretreatment with a nonbacteriolytic antibiotic, such as rifampin, has been shown to attenuate the inflammatory response in experimental models of bacterial meningitis. In a pilot study, in children with bacterial meningitis, we have studied markers of inflammatory response and neuronal damage in 2 groups of children with bacterial meningitis; one group received rifampin pretreatment with ceftriaxone and the other group received ceftriaxone alone...
June 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27847933/the-role-of-s100b-protein-as-a-potential-marker-in-affective-disorders
#7
REVIEW
Aleksandra Rajewska-Rager, Magdalena Pawlaczyk
INTRODUCTION: Both recurrent depressive disorders and affective bipolar disorders are characterized by the changes in glial tissue. S100B protein is a calcium-binding molecule, mainly secreted by glial cells, which, depending on its concentration, has a trophic or toxic effect on neuronal cells. In the recent years, due to the postulated glial hypothesis of affective disorders and the ideas concerning brain neuroplasticity, there has been a growing interest in S100B protein and its role in affective disorders...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27319802/serum-concentrations-of-ubiquitin-c-terminal-hydrolase-l1-and-glial-fibrillary-acidic-protein-after-pediatric-traumatic-brain-injury
#8
Stefania Mondello, Firas Kobeissy, Annarita Vestri, Ronald L Hayes, Patrick M Kochanek, Rachel P Berger
Objective reliable markers to assess traumatic brain injury (TBI) and predict outcome soon after injury are a highly needed tool for optimizing management of pediatric TBI. We assessed serum concentrations of Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in a cohort of 45 children with clinical diagnosis of TBI (Glasgow Coma Scale [GCS] 3-15) and 40 healthy subjects, evaluated their associations with clinical characteristics and outcomes, and compared their performance to previously published data on two well-studied blood biomarkers, S100B and MBP...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27272973/perioperative-risk-factors-for-impaired-neurodevelopment-after-cardiac-surgery-in-early-infancy
#9
Julia K Gunn, John Beca, Rodney W Hunt, Michelle Goldsworthy, Christian P Brizard, Kirsten Finucane, Susan Donath, Lara S Shekerdemian
OBJECTIVE: Historical cohort studies have reported adverse neurodevelopment following cardiac surgery during early infancy. Advances in surgical techniques and perioperative care have coincided with updating of neurodevelopmental assessment tools. We aimed to determine perioperative risk factors for impaired neurodevelopment at 2 years following surgery for congenital heart disease (CHD) in early infancy. DESIGN AND PATIENTS: We undertook a prospective longitudinal study of 153 full-term infants undergoing surgery for CHD before 2 months of age...
November 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27160122/mir-221-and-mir-222-simultaneously-target-arid1a-and-enhance-proliferation-and-invasion-of-cervical-cancer-cells
#10
Y Yang, X Zhao, H-X Li
OBJECTIVE: To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis. PATIENTS AND METHODS: 28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27160117/expression-level-of-nse-s100b-and-npy-in-children-with-acute-miliary-phthisis-and-secondary-tubercular-meningitis
#11
C-X Zhang, D-J Zhang, Y-L Wang, W Han, G-C Shi, H-Q Zhang
OBJECTIVE: To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis. PATIENTS AND METHODS: 28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26710878/elevated-levels-of-cerebrospinal-fluid-s100b-are-associated-with-brain-injury-and-unfavorable-outcomes-in-children-with-central-nervous-system-infections
#12
Qiong-Ling Peng, Shao-Hua Tao, Nan Yu, Xi-Zhong Zhou, Yong-Zheng Peng, Ning Fu
PURPOSE: This work aimed to assess whether elevated levels of cerebrospinal fluid (CSF) S100B are associated with brain injury and unfavorable outcomes at discharge in children with central nervous system (CNS) infections. METHODS: CSF S100B and associated clinical parameters were retrospectively analyzed in 83 children with CNS infections and 88 children without neurological pathology served as controls. Children with CNS infections were divided into an infectious encephalitis group and an infectious meningitis group based on whether cerebral parenchyma was involved, and CSF S100B levels in different age subgroups between the two groups were compared...
January 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26502808/acute-s100b-in-serum-is-associated-with-cognitive-symptoms-and-memory-performance-4-months-after-paediatric-mild-traumatic-brain-injury
#13
Martina Studer, Barbara Goeggel Simonetti, Theda Heinks, Maja Steinlin, Alexander Leichtle, Steffen Berger, Alexander Joeris
OBJECTIVE: This study explored whether acute serum marker S100B is related with post-concussive symptoms (PCS) and neuropsychological performance 4 months after paediatric mild traumatic brain injury (mTBI). RESEARCH DESIGN AND METHODS: This prospective short-term longitudinal study investigated children (aged 6-16 years) with mTBI (n = 36, 16 males) and children with orthopaedic injuries (OI, n = 27, 18 males) as a control group. S100B in serum was measured during the acute phase and was correlated with parent-rated PCS and neuropsychological performance 4 months after the injury...
2015: Brain Injury: [BI]
https://www.readbyqxmd.com/read/26479347/preanalytical-analytical-gestational-and-pediatric-aspects-of-the-s100b-immuno-assays
#14
Damien Bouvier, Thomas Duret, Paul Rouzaire, Matthieu Jabaudon, Marion Rouzaire, Céline Nourrisson, Céline Bourgne, Bruno Pereira, Bertrand Evrard, Vincent Sapin
BACKGROUND: Traumatic brain injury management is a tricky issue in children and pregnant women (due to adverse effects of computer tomography). To facilitate management, we report the main analytical performances and reference ranges for blood tests for the well-established S100B biomarker in under-16 children on a DiaSorin® Liaison XL analyzer and in pregnant women on DiaSorin® Liaison XL and Roche Diagnostics® Cobas e411 analyzers. METHODS: Serum S100B concentrations were determined by chemiluminescent immunoassay on a DiaSorin® analyzer in a population of 409 healthy children aged 0-16 years and on DiaSorin®/Roche Diagnostics® instruments in a population of 50 pregnant women (one blood sample for each trimester)...
May 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/26417594/circulating-s100b-and-adiponectin-in-children-who-underwent-open-heart-surgery-and-cardiopulmonary-bypass
#15
Alessandro Varrica, Angela Satriano, Alessandro Frigiola, Alessandro Giamberti, Guido Tettamanti, Luigi Anastasia, Erika Conforti, Antonio D W Gavilanes, Luc J Zimmermann, Hans J S Vles, Giovanni Li Volti, Diego Gazzolo
BACKGROUND: S100B protein, previously proposed as a consolidated marker of brain damage in congenital heart disease (CHD) newborns who underwent cardiac surgery and cardiopulmonary bypass (CPB), has been progressively abandoned due to S100B CNS extra-source such as adipose tissue. The present study investigated CHD newborns, if adipose tissue contributes significantly to S100B serum levels. METHODS: We conducted a prospective study in 26 CHD infants, without preexisting neurological disorders, who underwent cardiac surgery and CPB in whom blood samples for S100B and adiponectin (ADN) measurement were drawn at five perioperative time-points...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26356618/-biomarkers-in-children-with-traumatic-brain-injury
#16
V G Pinelis, E G Sorokina, J B Semenova, O V Karaseva, S V Mescheryakov, T A Chernisheva, E N Arsenieva, L M Roshal
OBJECTIVE: to study the content of biomarkers of diagnostic and prognostic value in the assessment of traumatic brain injury (TBI) severity in children. MATERIAL AND METHODS: Authors determined the levels of glial protein S100B, neuronspecific enolase (NSE), autoantibodies (aAb) to glutamate receptors and natural autoantibodies (nAb) to S100B and brain-derived neurotrophic factor (BDNF) in serum/plasma of children with different outcomes of TBI. All parameters were analyzed in the 1-3rd, 7-8th, 14-15th and 20-23rd days after TBI, and, in some cases of severe brain injury and long stay patients in hospital, in 11-12 months after TBI...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26316432/evaluation-of-pre-treatment-and-post-treatment-s100b-oxidant-and-antioxidant-capacity-in-children-with-diabetic-ketoacidosis
#17
Cemil Kaya, Ali Ataş, Nurten Aksoy, Esra Celen Kaya, Mahmut Abuhandan
OBJECTIVE: The study aimed to evaluate the pre-treatment and post-treatment oxidant capacity, antioxidant capacity and S100B protein levels in cases of diabetic ketoacidosis (DKA). METHODS: The study included 49 pediatric patients diagnosed with DKA and a control group comprising 49 healthy children. Blood samples were obtained after confirmation of the DKA diagnosis and also after treatment. S100B, total oxidant (TOL) and total antioxidant levels (TAL) were measured and the oxidative stress index (OSI) was calculated...
June 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26283067/diagnostic-performance-of-s100b-protein-serum-measurement-in-detecting-intracranial-injury-in-children-with-mild-head-trauma
#18
MULTICENTER STUDY
Sergio Manzano, Iris Bachmann Holzinger, Christian J Kellenberger, Laurence Lacroix, Dagmar Klima-Lange, Martin Hersberger, Giorgio La Scala, Stefan Altermatt, Georg Staubli
OBJECTIVE: To assess the accuracy of S100B serum level to detect intracranial injury in children with mild traumatic brain injury. METHODS: A multicenter prospective cohort study was carried out in the paediatric emergency departments of three tertiary hospitals in Switzerland between January 2009 and December 2011. Participants included children aged <16 years with a mild traumatic brain injury (GCS ≥13) for whom a head CT was requested by the attending physician...
January 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/26254728/levels-of-s100b-in-brain-and-blood-of-rats-with-diabetic-ketoacidosis
#19
Nicole Glaser, Weei Lo, Daniel Tancredi, Myra Orgain, Vikram Puvenna, Damir Janigro, Martha O'Donnell
Diabetic ketoacidosis (DKA) frequently causes subtle brain injuries in children. Rarely, these injuries can be severe and life threatening. The physiological processes leading to brain injury during DKA are poorly understood. S100B is a calcium-binding protein secreted by astrocytes. Elevated serum S100B levels are documented in several types of brain injuries. S100B may have either neuroprotective or neurotoxic effects, depending upon the concentration. We undertook the current studies to measure alterations in S100B production and secretion during DKA...
October 22, 2015: Brain Research
https://www.readbyqxmd.com/read/26082978/plasma-biomarkers-of-brain-injury-as-diagnostic-tools-and-outcome-predictors-after-extracorporeal-membrane-oxygenation
#20
Melania M Bembea, Nicole Rizkalla, James Freedy, Noah Barasch, Dhananjay Vaidya, Peter J Pronovost, Allen D Everett, Gregory Mueller
OBJECTIVE: To determine if elevations in plasma brain injury biomarkers are associated with outcome at hospital discharge in children who require extracorporeal membrane oxygenation. DESIGN: Prospective observational study. SETTING: Single tertiary-care academic center. PARTICIPANTS: Eighty children who underwent extracorporeal membrane oxygenation between June 2010 and December 2013. INTERVENTIONS: None...
October 2015: Critical Care Medicine
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