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Cognitive impairment in children

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https://www.readbyqxmd.com/read/28207506/higher-subcortical-and-white-matter-cerebral-blood-flow-in-perinatally-hiv-infected-children
#1
Charlotte Blokhuis, Henri J M M Mutsaerts, Sophie Cohen, Henriëtte J Scherpbier, Matthan W A Caan, Charles B L M Majoie, Taco W Kuijpers, Peter Reiss, Ferdinand W N M Wit, Dasja Pajkrt
This study aimed to evaluate cerebral blood flow (CBF) in pediatric human immunodeficiency virus (HIV)-infection, and its role in HIV-related cerebral injury and cognitive impairment.This cross-sectional observational study compared 28 perinatally HIV-infected children (8-18 years) to 34 healthy controls matched for age, sex, ethnicity, and socio-economic status. All participants underwent 3-Tesla magnetic resonance imaging, using arterial spin labeling to assess CBF in gray matter (GM), white matter (WM), basal ganglia, and thalamus...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28203113/the-influence-of-parenting-on-maladaptive-cognitive-schema-a-cross-sectional-research-on-a-group-of-adults
#2
Monica Pellerone, Calogero Iacolino, Giuseppe Mannino, Ivan Formica, Simona Maria Zabbara
BACKGROUND: The literature emphasizes the role of early interpersonal experiences in the development of cognitive vulnerability; in particular, interruptions in early family relationships, parental unavailability and dysfunctional parenting are potential evolutionary precursors to negative cognitive style and emotional disorders. MATERIALS AND METHODS: This study measured the relationship of retrospective ratings on parental bonding with cognitive patterns in a group of Italian adults...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28196142/moderate-injury-in-motor-sensory-cortex-causes-behavioral-deficits-accompanied-by-electrophysiological-changes-in-mice-adulthood
#3
Wei Ouyang, Qichao Yan, Yu Zhang, Zhiheng Fan
Moderate traumatic brain injury (TBI) in children often happen when there's a sudden blow to the frontal bone, end with long unconscious which can last for hours and progressive cognitive deficits. However, with regard to the influences of moderate TBI during children adulthood, injury-induced alterations of locomotive ability, long-term memory performance, and hippocampal electrophysiological firing changes have not yet been fully identified. In this study, lateral fluid percussion (LFP) method was used to fabricate moderate TBI in motor and somatosensory cortex of the 6-weeks-old mice...
2017: PloS One
https://www.readbyqxmd.com/read/28187370/language-comprehension-in-children-adolescents-and-adults-with-down-syndrome
#4
Bernadette Witecy, Martina Penke
BACKGROUND: There is conflicting evidence as to whether receptive language abilities of individuals with Down syndrome (DS) continue to improve into adulthood, reach a plateau in late adolescence, or even start to decline. AIM: The study aims to shed light on the question whether receptive syntactic skills change from childhood/adolescence to adulthood and provides a detailed qualitative analysis of the receptive abilities of adults with DS. METHODS: 58 individuals with DS participated in the study: 31 children/adolescents (aged: 4;6-19;0 years) and 27 adults (aged: 20;8-40;3 years)...
February 7, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28185206/what-you-don-t-know-can-hurt-you-the-risk-of-language-deprivation-by-impairing-sign-language-development-in-deaf-children
#5
Wyatte C Hall
A long-standing belief is that sign language interferes with spoken language development in deaf children, despite a chronic lack of evidence supporting this belief. This deserves discussion as poor life outcomes continue to be seen in the deaf population. This commentary synthesizes research outcomes with signing and non-signing children and highlights fully accessible language as a protective factor for healthy development. Brain changes associated with language deprivation may be misrepresented as sign language interfering with spoken language outcomes of cochlear implants...
February 9, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28177265/social-competence-at-2-years-following-child-traumatic-brain-injury
#6
Vicki Anderson, Miriam Helen Beauchamp, Keith Owen Yeates, Louise Crossley, Nicholas Peter Ryan, Stephen J C Hearps, Cathy Catroppa
Children with traumatic brain injury (TBI) are at risk of social impairment, but research is yet to document the trajectory of these skills post-injury and factors that may predict social problems. The study addressed these gaps in knowledge, reporting on findings from a prospective, longitudinal follow-up study which investigated social outcomes post injury and explored factors contributing to these outcomes at 2 years post-injury. The sample included 113 children, 74 with TBI and 39 typically developing (TD) controls...
February 8, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28173729/structural-and-functional-abnormalities-in-children-with-adhd-a-focus-on-subgenual-anterior-cingulate-cortex
#7
Chenyang Zhan, Yuhong Liu, Kai Wu, Yu Gao, Xiaobo Li
Attention-Deficit/Hyperactivity Disorder (ADHD), characterized by developmentally inappropriate inattention, hyperactivity/impulsivity, or a combination of both, is a major public health problem. Neuroimaging studies have revealed associations of these cognitive impairments with structural and functional deficits all over the brain. Existing findings are not fully consistent due to the heterogeneity of study samples and diversity of research techniques. In the current study, we propose to utilize a multi-modal MRI approach to study the structural and functional brain networks in children with ADHD-combined type (ADHD-C) with a focus on the subgenual anterior cingulate cortex (sgACC)...
February 7, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28168619/pure-endoscopic-management-of-epileptogenic-hypothalamic-hamartomas
#8
S Chibbaro, H Cebula, J Scholly, J Todeschi, I Ollivier, A Timofeev, M Ganau, P Di Emidio, M P Valenti, A M Staack, T Bast, B J Steinhoff, E Hirsch, P Kehrli, F Proust
Hypothalamic hamartomas (HH) are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Their usual clinical presentation is characterized by gelastic/dacrystic seizures which often become pharmaco-resistant and progress to secondary focal/generalized intractable epilepsy causing mostly in children cognitive and behavioral problems (particularly in cases of progressive epileptic encephalopathy) and precocious puberty. Whereas gelastic seizures can be surgically controlled either by resection of the lesion or disconnection (tissue-destructive) procedures, aimed at functionally prevent the spreading of the epileptic burst; generalized seizures tend to respond better to HH excision rather than isolated neocortical resections, which generally fail to control them...
February 7, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28166549/prior-history-of-feeding-swallowing-difficulties-in-children-with-language-impairment
#9
Kathy Malas, Natacha Trudeau, Marie-Claude Giroux, Lisanne Gauthier, Simone Poulin, David H McFarland
Purpose: This study updated and extended our previous investigation (Malas et al., 2015) of feeding-swallowing difficulties and concerns (FSCs) in children with language impairments (LI) by using more stringent inclusion criteria and targeting children earlier in the care delivery pathway. Method: Retrospective analyses were performed on the clinical files of 29 children (average age: 60 months, SD = 9.0) diagnosed as having LI using standardized testing, nonstandardized testing and final speech-language pathologist judgment...
February 1, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28162033/high-density-electroencephalographic-recordings-during-sleep-in-children-and-adolescents-with-acquired-brain-injury
#10
Anne-Laure Mouthon, Andreas Meyer-Heim, Salome Kurth, Maya Ringli, Fiona Pugin, Hubertus J A van Hedel, Reto Huber
BACKGROUND: Acquired brain injuries (ABI) such as traumatic brain injury (TBI) or stroke can result in motor, language, or cognitive impairments. Although a considerable number of studies have investigated functional recovery, underlying brain reorganization remains poorly understood. Accumulating evidence indicates that plastic processes in the brain are linked to changes in electroencephalographic (EEG) slow wave activity (SWA) during deep sleep (EEG spectral power 1-4.5 Hz). OBJECTIVE: We investigated sleep SWA in children and adolescents with ABI...
February 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28160687/social-attention-in-children-with-epilepsy
#11
Judith Lunn, Tim Donovan, Damien Litchfield, Charlie Lewis, Robert Davies, Trevor Crawford
Children with epilepsy may be vulnerable to impaired social attention given the increased risk of neurobehavioural comorbidities. Social attentional orienting and the potential modulatory role of attentional control on the perceptual processing of gaze and emotion cues have not been examined in childhood onset epilepsies. Social attention mechanisms were investigated in patients with epilepsy (n=25) aged 8-18years old and performance compared to healthy controls (n=30). Dynamic gaze and emotion facial stimuli were integrated into an antisaccade eye-tracking paradigm...
February 1, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28158932/the-association-of-neonatal-morbidity-with-long-term-neurological-outcome-in-infants-who-were-growth-restricted-and-preterm-at-birth-secondary-analyses-from-truffle-trial-of-randomized-umbilical-and-fetal-flow-in-europe
#12
A G Van Wassenaer-Leemhuis, N Marlow, C Lees, H Wolf
OBJECTIVE: To study the relationship between neonatal morbidity (NNM) and two-year neurodevelopmental impairment (NDI) in surviving children after early fetal growth restriction (FGR). DESIGN: Secondary analysis of a European randomised trial (TRUFFLE) of delivery for very preterm fetuses dependent on venous Doppler or cardiotocographic criteria. SETTING: Tertiary perinatal centres, participants in TRUFFLE. POPULATION: 402 surviving children after early FGR...
February 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28157749/arterial-ischemic-stroke-in-children-and-young-adults
#13
Warren D Lo, Riten Kumar
PURPOSE OF REVIEW: This article reviews risk factors, recurrence risk, evaluation, management, and outcomes of arterial ischemic stroke in children and young adults. RECENT FINDINGS: The risk for recurrence and mortality appear to be low for neonatal and childhood stroke. Most children have relatively mild deficits, but those who have greater neurologic deficits, poststroke epilepsy, or strokes early in life are at risk for lower overall cognitive function. Stroke recurrence and long-term mortality after stroke in young adults are greater than originally thought...
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28152334/a-comparison-of-the-efficacy-of-weight-shift-vs-joystick-control-of-a-robotic-mobility-device-by-infants-ages-5-to-10-months
#14
Sharon Stansfield, Carole Dennis, Rachel Altman, Janelle Smith, Hélène Larin
The onset of crawling in infants contributes to cognitive, perceptual, social, and emotional development. Conversely, infants with motor impairment that delays or prevents autonomous mobility often have associated developmental delays. Evidence suggests that providing mobility may have positive developmental outcomes, however powered wheelchairs may not be recommended for very young children, due to safety concerns and the child's level of cognitive maturity. The WeeBot is a mobility device controlled by infant weight shifting while seated; infants as young as 5 months have learned to use it...
February 2, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28148630/dysarthria-and-broader-motor-speech-deficits-in-dravet-syndrome
#15
Samantha J Turner, Amy Brown, Marta Arpone, Vicki Anderson, Angela T Morgan, Ingrid E Scheffer
OBJECTIVE: To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS: Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS: Speech was characterized by imprecise articulation, abnormal nasal resonance, voice, and pitch, and prosody errors. Half of verbal patients had moderate to severely impaired conversational speech intelligibility...
February 1, 2017: Neurology
https://www.readbyqxmd.com/read/28145624/severe-intellectual-disability-is-not-a-contraindication-to-kidney-transplantation-in-children
#16
Ashton Chen, Alan Farney, Gregory B Russell, Linda Nicolotti, Robert Stratta, Jeffrey Rogers, Jen-Jar Lin
Renal transplantation in children with ID is controversial. Acceptability of these children as candidates varies between programs. Limited outcome data in pediatric renal TXP recipients with cognitive impairment diminish their access to TXP. A retrospective chart review was performed of all children who underwent renal transplantation between January 1, 2002 and June 30, 2012 (N=72). Patients were divided into two groups, those with ID prior to transplantation (n=10) and those without (non-ID; n=62). Graft survival and BPAR episodes were compared between the two groups using Kaplan-Meier estimates...
February 1, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28141740/preventing-cognitive-impairment-in-children-with-epilepsy
#17
Kees P J Braun
PURPOSE OF REVIEW: Cognitive impairments are common in children with epilepsy. They may already be present before the onset of epilepsy or occur - and even progress - during its course. Many variables contribute to cognitive dysfunction. Those that can be targeted to prevent (further) cognitive impairment will be highlighted in this review. RECENT FINDINGS: Ideally, but not yet realistically, epileptogenesis is prevented to avert seizures and cognitive impairments in high-risk patients...
January 30, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28141739/improving-cognitive-outcomes-for-pediatric-stroke
#18
Mardee Greenham, Vicki Anderson, Mark T Mackay
PURPOSE OF REVIEW: The past 20 years have seen a 35% increase in prevalence of pediatric stroke. Contrary to widely held views, children do not recover better than adults. This review explores the impact of pediatric stroke on cognitive domains, including intellectual and executive functions, memory and behavior, and the influence of age, lesion characteristics, and comorbidities on outcome. RECENT FINDINGS: Cognitive problems occur in up to half of ischemic and hemorrhagic stroke survivors...
January 30, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28132125/does-the-presence-of-anxiety-and-adhd-symptoms-add-to-social-impairment-in-children-with-autism-spectrum-disorder
#19
Reina S Factor, Sarah M Ryan, Julee P Farley, Thomas H Ollendick, Angela Scarpa
Children with autism spectrum disorder (ASD) experience internalizing and externalizing problems at higher rates than typically developing children, which could worsen social impairment. The present study compared impairment scores (social responsiveness scale, 2nd edition; SRS-2 scores) in 57 children (3-17 years, 82.5% male) with ASD, either with or without heightened levels of anxiety or ADHD symptoms, all per parent report. Children with heightened anxiety problems showed higher scores on four SRS-2 subscales (Social Cognition, Social Communication, Social Motivation, and Restricted Interests and Repetitive Behavior)...
January 28, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28130818/neurocognitive-outcomes-among-children-who-experienced-seizures-during-treatment-for-acute-lymphoblastic-leukemia
#20
Stephanie L Nassar, Heather M Conklin, Yinmei Zhou, Jason M Ashford, Wilburn E Reddick, John O Glass, Fred H Laningham, Sima Jeha, Cheng Cheng, Ching-Hon Pui
BACKGROUND: Limited information is available regarding neurocognitive outcomes of children who experience seizures during treatment for acute lymphoblastic leukemia (ALL). Accordingly, the main objectives of this study were to determine the incidence and risk factors for treatment-related seizures among children with ALL, and the neurocognitive outcomes associated with treatment-related seizures. PROCEDURE: Prospective neuropsychological assessment and magnetic resonance imaging (MRI) were planned for all 498 patients with newly diagnosed ALL enrolled on the St...
January 28, 2017: Pediatric Blood & Cancer
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