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S100B and general anaesthesia

Pablo Mesa Suárez, José Diego Santotoribio, Victoria Ramos Ramos, María Ángela González García, Santiago Pérez Ramos, David Portilla Huertas, Antonio Muñoz Hoyos
BACKGROUND AND OBJECTIVE: S100B protein is a serum marker of cerebral damage. The objective was to evaluate the brain damage caused by general anaesthesia, by determining the concentration of serum S100B protein before and after of general anaesthesia. PATIENTS AND METHOD: Patients with chronic adenotonsillar hypertrophy and indications for tonsillectomy were included. A venous blood sample was taken from the patients before general anaesthesia (basal sample). The patients were anaesthetised using the following intravenous anaesthetic drugs: midazolam, fentanyl and propofol; and inhaled sevoflurane...
May 6, 2016: Medicina Clínica
Berndt Arfvidsson, Torbjörn K Nilsson, Lars Norgren
BACKGROUND: Our aim was to test the hypothesis that metabolic and inflammatory responses of the brain perioperatively during carotid endarterectomy (CEA) might affect blood brain barrier (BBB) integrity. METHODS: Twenty patients with >70% stenosis of internal carotid artery (ICA) were prospectively included. Surgery was performed under general anaesthesia. Blood was sampled from ipsilateral internal jugular vein and radial artery: just before, during, and after ICA clamping S100B protein, glucose, lactate, 20 amino acids, and key cytokines were analysed...
January 2015: Clinical Chemistry and Laboratory Medicine: CCLM
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