Ji Eun Kim, Ayun Seol, Yun Ju Choi, Su Jin Lee, You Jeong Jin, Yu Jeong Roh, Hee Jin Song, Jin Tae Hong, Dae Youn Hwang
CRISPR-Cas9-mediated leptin (Lep) knockout (KO) mice exhibited prominent phenotypes for constipation, even though they were not compared with other model animals. This study compared the stool excretion, gastrointestinal motility, histological structure, mucin secretion, and enteric nerve function in Lep KO and high fat diet (HFD)-treated mice to determine if there were differences in their phenotypes for constipation. Most obesity phenotypes, including fat weight, adipocyte size, expression of lipolytic proteins (HSL, perilipin, and ATGL), and glucose concentrations, were detected similarly in the Lep KO and HFD-treated mice...
2022: PloS One