Mathilde Coquaz-Garoudet, Dominique Ploin, Robin Pouyau, Yoav Hoffmann, Julien-Frederic Baleine, Benoît Boeuf, Hugues Patural, Anne Millet, Marc Labenne, Renaud Vialet, Didier Pinquier, Marie Cotillon, Jérôme Rambaud, Etienne Javouhey
BACKGROUND: Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia and hyperleukocytosis up to 50 G/l, leading to multiple organ failure and death in 75% of cases. Leukodepletion may improve prognosis. A therapeutic strategy based on leukodepletion and extracorporeal life support (ECLS) according to different thresholds of leucocytes has been proposed by Rowlands and colleagues. We aimed at identifying factors associated with death and assess whether the respect of the Rowlands' strategy is associated with survival...
May 7, 2021: Annals of Intensive Care