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Jesús Millán-Núñez, Teresa Mantilla-Morató, Rocio Toro, Joaquin J Millán-Pérez, Alipio Mangas-Rojas
AIMS: High levels of plasma triglycerides (TG) are a risk factor for cardiovascular diseases often associated with anomalies in other lipids or lipoproteins. However, results from randomized trials, suggesting that low high density lipoprotein cholesterol (HDLc) might not cause cardiovascular disease, as originally thought, have generated renewed interest in increased concentrations of TG. The objective has been to determine the prevalence and factors associated with hypertrigliceridemia (HTG) and with low HDLc...
2016: Current Pharmaceutical Design
Danilo Di Bona, Angelo B Cefalù, Elisabetta Scirè, Giacomo M Lima, Claudia Maria Rizzo, Antonina Giammanco, Carlo M Barbagallo, Maurizio R Averna, Sergio Rizzo, Calogero Caruso
BACKGROUND: Chylomicronemia syndrome is a metabolic condition characterized by severe fasting hypertrigliceridemia (≥ 1000 mg/dL) and other clinical features including chronic abdominal pain and recurrent acute pancreatitis. In patients with acute or recurrent pancreatitis, plasma exchange (PEx) is indicated for the treatment of acute disease and prevention of recurrence. The use of plasma instead of albumin as replacement fluid has been suggested for its putative ability to replace the deficient enzyme possibly leading to better clinical improvement...
March 2016: Transfusion
Aleksandra Lučić Prokin, Agota Čuzdi, Zeljko Zivanović, Jelena Sekarić, Timea Kokai Zekić, Nemanja Popović, Jovanka Novaković Paro
AIM: Most of the studies proved association between some lipoprotein fractions and hypocholesterolemia as risk factors for primary intracerebral hemorrhage (ICH). However, there are studies that emphasize hypercholesterolemia (Hyper-Hol) as a risk factor. The present study aims at determining lipid fractions as risk factors for intracerebral hemorrhage in our region. METHODS: A retrospective study included 92 patients with primary ICH treated during one year at the Department of Neurology in the Clinical Centre of Vojvodina, Novi Sad...
February 2014: Medicinski Glasnik
V Ramistella, M Wasniewska, M Valenzise, D Corica, S Cantucci, E Pitrolo, M Romeo, F De Luca
UNLABELLED: Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is a rare and complex pediatric disorder. Children typically show ROHHAD after the first years of life with rapid weight gain and subsequently autonomic nervous system dysregulation (altered pain perception, pupillary dysfunction, hypothermia and bradycardia); alveolar hypoventilation with risk of cardiorespiratory arrest and hypothalamic dysfunction (central diabetes insipidus, hypothyroidism, growth hormone and corticotrophin deficiency)...
July 2013: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Ignacio Sola Galarza, Borja López López, Carlos Llorente Abarca
We define dyslipemia as the abnormally elevated presence of lipids in the blood. The main ones are hypercholesterolemia (cholesterol over 240 mg/dl), hypertrigliceridemia (triglicerides level over 200 mg/dl) and hipo-alphalipoproteinemia (High density lipoproteins,also called HDL Cholesterol, below 40 mg/dl). The presence of excessive lipids contributes to arteriosclerosis and they are an independent cardiovascular risk factor. It may be primary, if they have genetic origin and they are not associated with other diseases, but in most cases they are secondary to other pathological entities such as diabetes, hypothyroidism, obesity and metabolic syndrome (MS)...
September 2013: Archivos Españoles de Urología
Rosane Aparecida Ribeiro, Sandra Lucinei Balbo, Letícia Prates Roma, Rafael Ludemann Camargo, Luiz Felipe Barella, Emerielle Cristine Vanzela, Paulo Cesar de Freitas Mathias, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Maria Lúcia Bonfleur
Monosodium glutamate-obese rats are glucose intolerant and insulin resistant. Their pancreatic islets secrete more insulin at increasing glucose concentrations, despite the possible imbalance in the autonomic nervous system of these rats. Here, we investigate the involvement of the cholinergic/protein kinase (PK)-C and PKA pathways in MSG β-cell function. Male newborn Wistar rats received a subcutaneous injection of MSG (4 g/kg body weight (BW)) or hyperosmotic saline solution during the first 5 days of life...
July 2013: Molecular Biology Reports
Claudio Annaloro, Lorena Airaghi, Giorgia Saporiti, Francesco Onida, Agostino Cortelezzi, Giorgio Lambertenghi Deliliers
The term metabolic syndrome (MS) defines a clustering of cardiovascular risk factors, formerly known as syndrome X. There is some debate about the diagnostic criteria; but the most widely accepted framework is that defined by the National Cholesterol Education Program Adult Treatment Panel III, which requires the simultaneous occurrence of at least three of abdominal obesity, arterial hypertension, hyperglycemia, hypertrigliceridemia and low high-density lipoprotein cholesterol (HDL-C). The prevalence of MS increases with age and varies depending on genetic factors...
August 2012: Expert Review of Hematology
Aldo Ferreira Hermosillo, Guadalupe Vargas Ortega, Baldomero González Virla, Moisés Mercado Atri, Mario Molina Ayala
BACKGROUND: Double diabetes is the association between type 1 diabetes mellitus (DM1) and metabolic syndrome (MS). The prevalence of hypertension, dyslipidemia, central obesity and macrovascular complications has increased in DM1 patients, regardless glycemic control. OBJECTIVE: To determine the prevalence of MS in patients with DM1. METHODS: We performed a descriptive cross-sectional study of clinical characteristics of DM1 patients. Biochemical and anthropometric parameters were determined and the presence of hypertension, dyslipidemia and central obesity were assessed...
March 2012: Gaceta Médica de México
Chiara Giannarelli, Robert S Klein, Juan J Badimon
Cardiovascular disease (CVD) is currently the second most frequent cause of death (after cancer) among HIV-positive subjects. The clinical use of highly active antiretroviral therapy (HAART) has dramatically reduced mortality and morbidity in HIV-positive population, leading to prolonged and improved quality of life. However, as mortality and morbidity from AIDS-related conditions improve, CVD assumes increasing magnitude. It is estimated that by 2015 more than 50% of HIV-positive patients will be older than 50 years...
December 2011: Atherosclerosis
Edgar Navarro, Volga Mijac, Hermes Flórez y Elena Ryder
Abdominal obesity and specifically intrabdominal adiposity leads to increase in cardiometabolic risk factors (CMR), independently of body mass index (BMI). In order to examine CMR factors associated with the presence of visceral fat (VF) in individuals with different degrees of overweight/obesity, 154 men, 20 to 60 years of age, attending a at an Industrial Clinic in Venezuela, were evaluated. Ultrasound was used to establish the presence and amount of VF. As expected, VF values were higher as the BMI increased...
June 2010: Archivos Latinoamericanos de Nutrición
Pedro Valdivielso, Xavier Pintó, Rocio Mateo-Gallego, Lluis Masana, Luis Alvarez-Sala, Estíbaliz Jarauta, Manuel Suárez, Carlota García-Arias, Nuria Plana, Fernando Laguna
BACKGROUND AND OBJECTIVE: to show clinical features of subjects with hypertriglyceridemia (HTG) referred to the Lipid Units associated to Spanish Arteriosclerosis Society (ULSEA). PATIENTS AND METHOD: it is a prospective, cross-sectional, multicentric study of patients with serum Tgs > 200mg/dL, recruited from January 2007 to December 2008. Demographic, drug therapies, anthropometrical, main diagnosis and biochemical parameters were registered. RESULTS: We included 1,033 men and 361 women, 50±12 years-old...
March 12, 2011: Medicina Clínica
Gordana Jakovljević, Ika Kardum-Skelin, Srdan Rogosić, Srdana Culić, Jasminka Stepan, Alenka Gagro, Ivancica Skarić, Lili Mikecin, Aleksandra Bonevski, Ingeborg Barisić, Melita Nakić
Familial hemophagocytic lymphohistiocytosis (FLH) is an autosomal recessively inherited multisystem disease. This defect in cellular cytotoxicity is a life threatening condition characterized by fever, rash, splenomegaly, cytopenias and neurologic manifestations. PRF1, UNC13D and STX11 gene defects underlie in about 40-50% of primary cases. Chemoimmunotherapy followed by hematopoietic stem cell transplantation improved disease outcome. We report a case of a 6-week-old boy who presented with a fever, diffuse rash, disseminated intravascular coagulation, hypofibrinogenemia, hypertrigliceridemia, hepatosplenomegaly, leukocytosis with 90% of lymphocytes, granulocytopenia, anemia, trombocytopenia, hyperferritinemia and pathological findings in cerebrospinal fluid...
June 2010: Collegium Antropologicum
M Di Capua, M N D Di Minno, A Guida, M Loffredo, C Cuccaro, A Coppola, R Izzo, N Macarone Palmieri, A Crispo, A M Cerbone, G Di Minno
Forty-five consecutive subjects (26M, 19F; mean age 54 ± 14 yrs) with a diagnosed retinal vein occlusion (RVO), were followed-up for 8 yrs. As many as 145 sex-age- and blood pressure-matched individuals (78M, 67F; mean age 54.4 ± 13.5 yrs), that did not experience any vascular event, served as controls. At the time of the RVO, controls and subjects did not differ as to hypercholesterolemia, hypertrigliceridemia, diabetes mellitus, smoking habits, inherited/acquired thrombophilia. At the follow-up completion, they differed as to statin consumption (p = 0...
January 2012: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Simón Barquera, Ismael Campos-Nonato, Citlali Carrión-Rábago, Salvador Villalpando, Ruy López-Ridaura, Rosalba Rojas, Carlos A Aguilar-Salinas
OBJECTIVE: To describe: a) the methods used to quantify biochemical indicators of Type 2 Diabetes (T2D), and other cardiovascular risk indicators in the Mexican National Health and Nutrition Survey 2006 (ENSANUT 2006) and b) compare the sub-sample with the non-selected participants in diverse socio-demographic, anthropometric and health characteristics. MATERIAL AND METHODS: A sub-sample of 6 021 fasting adult participants was randomly selected from the total fasting participants (n=39 425)...
2010: Salud Pública de México
Carla Yamashita, Renata Damião, Rita Chaim, Helena Aiko Harima, Mário Kikuchi, Laércio J Franco, Sandra Roberta G Ferreira
OBJECTIVE: Interethnic marriage between nikkey Brazilians and non-nikkey Brazilians may favor the westernization of diet. Dietary consumption, clinical data and frequencies of metabolic diseases were compared in a Japanese-Brazilian population, with intraethnic or interethnic marriage. METHODS: T test, Mann-Whitney, chi-square and Person coefficient were used. RESULTS: Among 1009 Japanese-Brazilians there were 18.9% of interethnic marriage, being more frequent among nikkey men...
July 2009: Arquivos Brasileiros de Endocrinologia e Metabologia
María Elena Romero-Lbargüengoitia, Israel Lerman-Garber, Miguel Francisco Herrera-Hernández, Juan Pablo-Pantoja, Mauricio Sierra-Salazar, Federico López-Rosales, Margarita Zamora-Barrón, Angeles Vargas-Martínez, Eduardo García-García
INTRODUCTION: Morbid obesity is a serious health problem associated to a significant reduction in life expectancy. OBJECTIVE: To evaluate the anthropometric and metabolic changes observed in obese patients, 3, 6 and 12 months after laparoscopic Roux-en-Y gastric bypass surgery and the complications associated with the procedure. MATERIAL AND METHODS: Retrospective study that included 128 consecutive obese patients submitted for bariatric surgery at the INCMNSZ (2004-2006)...
May 2009: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
V V Ambroskina, T A Kriachok, O P Larionov, V V Bratus', T V Talaieva
The aim of the study was to investigate the pattern of lipid and lipoprotein metabolism disturbances in patients with manifested clinical signs of coronary atherosclerosis. There was determined the significance of hypertrigliceridemia as the marker of these disturbances and its connection with other most important factors of atherogenesis such as insulin resistance, systemic inflammation, and oxidative stress, blood lipoprotein modification. The role of excessive alimentary lipid consumption as a factor, which initiates the hypertrigliceridemia development and accompanying activation of the other proatherogenic factors was determined with the use of acute lipid loading...
2008: Fiziolohichnyĭ Zhurnal
José L Llisterri Caro, José L Gorriz Teruel, Francisco J Alonso Moreno, María J Manzanera Escribano, Gustavo C Rodríguez Roca, Vivencio Barrios Alonso, Salvador Lou Arnal, José R Banegas Banegas, Arantxa Matalí Gilarranz et al.
BACKGROUND AND OBJECTIVE: Information about the prevalence of chronic kidney disease (CKD) in population treated in primary care (PC) is scarce. The aim of this study was to determine undetected CKD prevalence in dyslipidemic population measuring creatinine clearance according to the Cockcroft-Gault equation corrected for surface area. PATIENTS AND METHOD: Cross-sectional study including patients with diagnosis of dyslipidemia selected by consecutive sampling in PC...
February 9, 2008: Medicina Clínica
Ernesto P de Oliveira, Maria das Dores A v Lima, Mirabeau Levi A de Souza
The diagnosis of the metabolic syndrome (MS) according to the National Cholesterol Education Program Adult Treatment Panel III does not reflect necessarily the presence of insulin resistance (IR), a potential therapeutical target for type 2 diabetes and cardiovascular disease prevention. Based on previous prevalence data, a cross-sectional study was conducted to determine the HOMA-IR relationship to the MS and some associated abnormalities. HOMA-IR > was higher in individuals with the MS (2.8+/-1.6 vs. 1...
December 2007: Arquivos Brasileiros de Endocrinologia e Metabologia
Milica Pesić, Slobodan Antić, Radivoj Kocić, Danijela Radojković, Sasa Radenković
BACKGROUND/AIMS: Overt hypothyroidism is disease associated with accelerated arteriosclerosis and coronary heart disease. Whether subclinical hypothyroidism (SH) is associated with increased cardiovascular risk is contraversial. As SH is a high prevalence thyroid dysfunction, specially in older women, it is important to evaluate cardiovascular risk factors in these patients and that was the aim of this study. METHODS: We examined 30 patients with SH and 20 healthy controls...
November 2007: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
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