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https://www.readbyqxmd.com/read/28230346/high-strength-stereolithographic-3d-printed-nanocomposites-graphene-oxide-metastability
#1
Jill Z Manapat, Joey Dacula Mangadlao, Brylee David Buada Tiu, Grace C Tritchler, Rigoberto C Advincula
The weak thermomechanical properties of commercial 3D printing plastics have limited the technology's application mainly to rapid prototyping. In this report, we demonstrate a simple approach that takes advantage of the metastable, temperature-dependent structure of graphene oxide (GO) to enhance the mechanical properties of conventional 3D-printed resins produced by stereolithography (SLA). A commercially available SLA resin was reinforced with minimal amounts of GO nanofillers and thermally annealed at 50 °C and 100 °C for 12 hours...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28230154/compiler-aided-systematic-construction-of-large-scale-dna-strand-displacement-circuits-using-unpurified-components
#2
Anupama J Thubagere, Chris Thachuk, Joseph Berleant, Robert F Johnson, Diana A Ardelean, Kevin M Cherry, Lulu Qian
Biochemical circuits made of rationally designed DNA molecules are proofs of concept for embedding control within complex molecular environments. They hold promise for transforming the current technologies in chemistry, biology, medicine and material science by introducing programmable and responsive behaviour to diverse molecular systems. As the transformative power of a technology depends on its accessibility, two main challenges are an automated design process and simple experimental procedures. Here we demonstrate the use of circuit design software, combined with the use of unpurified strands and simplified experimental procedures, for creating a complex DNA strand displacement circuit that consists of 78 distinct species...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229023/toxgen-an-improved-reference-database-for-the-identification-of-type-b-trichothecene-genotypes-in-fusarium
#3
Tomasz Kulik, Kessy Abarenkov, Maciej Buśko, Katarzyna Bilska, Anne D van Diepeningen, Anna Ostrowska-Kołodziejczak, Katarzyna Krawczyk, Balázs Brankovics, Sebastian Stenglein, Jakub Sawicki, Juliusz Perkowski
Type B trichothecenes, which pose a serious hazard to consumer health, occur worldwide in grains. These mycotoxins are produced mainly by three different trichothecene genotypes/chemotypes: 3ADON (3-acetyldeoxynivalenol), 15ADON (15-acetyldeoxynivalenol) and NIV (nivalenol), named after these three major mycotoxin compounds. Correct identification of these genotypes is elementary for all studies relating to population surveys, fungal ecology and mycotoxicology. Trichothecene producers exhibit enormous strain-dependent chemical diversity, which may result in variation in levels of the genotype's determining toxin and in the production of low to high amounts of atypical compounds...
2017: PeerJ
https://www.readbyqxmd.com/read/28228632/physical-and-psychological-characteristics-of-the-community-dwelling-elderly-with-heart-disease
#4
Takeshi Kera, Hisashi Kawai, Hideyo Yoshida, Hirohiko Hirano, Motonaga Kojima, Yoshinori Fujiwara, Kazushige Ihara, Shuichi Obuchi
Objectives Although the survival rates of patients with heart diseases, such as myocardial infarction and heart failure, have increased, the incidence of heart disease in elderly individuals has also increased. We compared characteristics of the community-dwelling elderly with heart diseases (heart disease group) and without heart diseases (non-heart disease group).Methods A total of 758 elderly individuals participated in our survey ("Otassha-kensin") in 2014. The heart disease group (47 men, 28 women) and the non-heart disease group (263 men, 420 women) were selected from among these participants...
2017: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/28227909/neuromorphic-circuit-modeling-directional-selectivity-in-the-visual-cortex
#5
Saeid Barzegarjalali, Alice C Parker, Saeid Barzegarjalali, Alice C Parker, Alice C Parker, Saeid Barzegarjalali
We have designed a neuromorphic circuit that models directional selectivity in the visual cortex, where selected neurons fire depending on the direction of object motion, along with the size and orientation of the object. The neuromorphic circuit is biomimetic. It consists of neurons and synapses, and models biological mechanisms. Neurons (including the Axon Hillock and the Dendritic Arbor) are designed with CMOS technology and synapses (both excitatory and inhibitory) are designed with Carbon Nanotube Transistors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227803/ear-eeg-allows-extraction-of-neural-responses-in-challenging-listening-scenarios-a-future-technology-for-hearing-aids
#6
L Fiedler, J Obleser, T Lunner, C Graversen, L Fiedler, J Obleser, T Lunner, C Graversen, J Obleser, C Graversen, L Fiedler, T Lunner
Advances in brain-computer interface research have recently empowered the development of wearable sensors to record mobile electroencephalography (EEG) as an unobtrusive and easy-to-use alternative to conventional scalp EEG. One such mobile solution is to record EEG from the ear canal, which has been validated for auditory steady state responses and discrete event related potentials (ERPs). However, it is still under discussion where to place recording and reference electrodes to capture best responses to auditory stimuli...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227483/a-real-time-remote-video-streaming-platform-for-ultrasound-imaging
#7
Mehdi Ahmadi, Warren J Gross, Samuel Kadoury, Mehdi Ahmadi, Warren J Gross, Samuel Kadoury, Samuel Kadoury, Warren J Gross, Mehdi Ahmadi
Ultrasound is a viable imaging technology in remote and resources-limited areas. Ultrasonography is a user-dependent skill which depends on a high degree of training and hands-on experience. However, there is a limited number of skillful sonographers located in remote areas. In this work, we aim to develop a real-time video streaming platform which allows specialist physicians to remotely monitor ultrasound exams. To this end, an ultrasound stream is captured and transmitted through a wireless network into remote computers, smart-phones and tablets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227140/map-reduce-for-optimizing-a-large-scale-dynamic-network-the-internet-of-hearts
#8
Chen Kan, Fabio M Leonelli, Hui Yang, Chen Kan, Fabio M Leonelli, Hui Yang, Hui Yang, Chen Kan, Fabio M Leonelli
Rapid advancements of sensing and mobile technology provide an unprecedented opportunity to empower smart and connected healthcare. Realizing the full potential of connected care depends, however, to a great extent on the capability of data analytics. Our previous study proposed a next-generation mobile health system, namely, the Internet of Heart (IoH). The IoH embeds patients into a dynamic network, where the distance between network nodes is determined by the dissimilarity of patients' conditions. Dynamics of the network reveal the change of clinical status of patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226891/an-implantable-microelectrode-array-for-dopamine-and-electrophysiological-recordings-in-response-to-l-dopa-therapy-for-parkinson-s-disease
#9
Song Zhang, Yilin Song, Jun Jia, Guihua Xiao, Lili Yang, Min Sun, Mixia Wang, Xinxia Cai, Song Zhang, Yilin Song, Jun Jia, Guihua Xiao, Lili Yang, Min Sun, Mixia Wang, Xinxia Cai, Xinxia Cai, Lili Yang, Guihua Xiao, Mixia Wang, Yilin Song, Song Zhang, Min Sun, Jun Jia
Dual-mode multielectrode recordings have become routine in rodent neuroscience research. However, robust and reliable application of acute, multielectrode recording methods in brain especially for in vivo research remains a challenge. In patients with Parkinson's disease (PD), the efficacy of L-dopa therapy depends on its ability to restore Dopamine (DA) neurotransmission in the striatum. In this paper, We describe a low cost thin film 16 sites implantable microelectrode array (MEA) chip fabricated by standard lithography technology for in vivo test...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226851/transcranial-focused-ultrasound-for-bold-fmri-signal-modulation-in-humans
#10
Leo Ai, Jerel K Mueller, Andrea Grant, Yigitcan Eryaman, Wynn Legon, Leo Ai, Jerel K Mueller, Andrea Grant, Yigitcan Eryaman, Wynn Legon, Andrea Grant, Wynn Legon, Yigitcan Eryaman, Leo Ai, Jerel K Mueller
Transcranial focused ultrasound (tFUS) is an emerging form of non-surgical human neuromodulation that confers advantages over existing electro and electromagnetic technologies by providing a superior spatial resolution on the millimeter scale as well as the capability to target sub-cortical structures non-invasively. An examination of the pairing of tFUS and blood oxygen level dependent (BOLD) functional MRI (fMRI) in humans is presented here.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226459/a-simple-method-for-micropatterning-nanofibrous-hydrogel-film
#11
K Higashi, N Miki, K Higashi, N Miki, K Higashi, N Miki
This paper propose a new fabrication process for micropatterning a nanofibrous thin film made of bacterial cellulose(BC). BC is a hydrogel produced by specific bacteria and composed of pure cellulosic nanoflbers exhibiting 3D network structure. Such nanofibrous structure is found to be appropriate for adhesion of anchorage-dependent cells. Furthermore, BC shows high biocompatibility and mechanical toughness. Thus, the microfabrication technique for BC broadens potentials for applications. In this study, we report a new method for micropatterning BC film with feature resolution comparable with photolithography technology...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226236/new-strategies-and-tools-in-quantitative-genetics-how-to-go-from-the-phenotype-to-the-genotype
#12
C Bazakos, M Hanemian, C Trontin, J M Jiménez-Gómez, O Loudet
Quantitative genetics has a long history in plants: It has been used to study specific biological processes, identify the factors important for trait evolution, and breed new crop varieties. These classical approaches to quantitative trait locus mapping have naturally improved with technology. In this review, we show how quantitative genetics has evolved recently in plants and how new developments in phenotyping, population generation, sequencing, gene manipulation, and statistics are rejuvenating both the classical linkage mapping approaches (for example, through nested association mapping) as well as the more recently developed genome-wide association studies...
February 6, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/28226210/real-time-nanoscale-open-circuit-voltage-dynamics-of-perovskite-solar-cells
#13
Joseph L Garrett, Elizabeth M Tennyson, Miao Hu, Jinsong Huang, Jeremy N Munday, Marina S Leite
Hybrid organic-inorganic perovskites based on methylammonium lead iodide (MAPbI3) are an emerging material with great potential for high-performance and low-cost photovoltaics. However, for perovskites to become a competitive and reliable solar cell technology, their instability and spatial variation must be understood and controlled. While the macroscopic characterization of the devices as a function of time is very informative, a nanoscale identification of their real-time local optoelectronic response is still missing...
February 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28225893/lncrna-snhg12-promotes-cell-growth-and-inhibits-cell-apoptosis-in-colorectal-cancer-cells
#14
J Z Wang, C L Xu, H Wu, S J Shen
Several long non-coding RNA (lncRNA) might be correlated with the prognosis of colorectal cancer (CRC) and serve as a diagnostic and prognostic biomarker. However, the exact expression pattern of small nucleolar RNA host gene 12 (SNHG12) in colorectal cancer and its clinical significance remains unclear. The level of SNHG12 was detected by qRT-PCR in CRC tissues and CRC cells. MTT assay and colony formation assay were performed to examine the cell proliferation of CRC cells transfected with pcDNA-SNHG12 or si-SNHG12...
February 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28225447/environmental-market-factors-associated-with-electronic-health-record-adoption-among-cancer-hospitals
#15
Will L Tarver, Nir Menachemi
BACKGROUND: Although recent literature has explored the relationship between various environmental market characteristics and the adoption of electronic health records (EHRs) among general, acute care hospitals, no such research currently exists for specialty hospitals, including those providing cancer care. PURPOSE: The aim of the study was to examine the relationship between market characteristics and the adoption of EHRs among Commission on Cancer (CoC)-accredited hospitals...
February 22, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28225056/comparative-rna-seq-analysis-of-transcriptome-dynamics-during-petal-development-in-rosa-chinensis
#16
Yu Han, Huihua Wan, Tangren Cheng, Jia Wang, Weiru Yang, Huitang Pan, Qixiang Zhang
The developmental process that produces the ornate petals of the China rose (Rosa chinensis) is complex and is thought to depend on the balanced expression of a functionally diverse array of genes; however, the molecular basis of rose petal development is largely unknown. Here, petal growth of the R. chinensis cultivar 'Old Blush' was divided into four developmental stages, and RNA-seq technology was used to analyse the dynamic changes in transcription that occur as development progresses. In total, 598 million clean reads and 61,456 successfully annotated unigenes were obtained...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223856/uncertainties-around-incretin-based-therapies-a-literature-review
#17
REVIEW
Bader Al Tulaihi, Samia Alhabib
Background: Diabetes mellitus is a chronic debilitating and non-communicable disease. It has several long-term outcomes that are associated with various end organ damage, mainly the heart, blood vessels, eyes, nerves, and kidneys. There are different modalities of treatment of diabetes. The recent incretin-based therapies provided an innovative class of drugs including GLP-1 receptor agonists and DPP-4 inhibitors. This review aims to summarize the available evidence of their effectiveness. Method: This is a narrative review...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28223488/large-nonsaturating-magnetoresistance-and-signature-of-nondegenerate-dirac-nodes-in-zrsis
#18
Ratnadwip Singha, Arnab Kumar Pariari, Biswarup Satpati, Prabhat Mandal
Whereas the discovery of Dirac- and Weyl-type excitations in electronic systems is a major breakthrough in recent condensed matter physics, finding appropriate materials for fundamental physics and technological applications is an experimental challenge. In all of the reported materials, linear dispersion survives only up to a few hundred millielectronvolts from the Dirac or Weyl nodes. On the other hand, real materials are subject to uncontrolled doping during preparation and thermal effect near room temperature can hinder the rich physics...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223461/identification-of-a-pseudomonas-aeruginosa-pao1-dna-methyltransferase-its-targets-and-physiological-roles
#19
Sebastian Doberenz, Denitsa Eckweiler, Olga Reichert, Vanessa Jensen, Boyke Bunk, Cathrin Spröer, Adrian Kordes, Emanuela Frangipani, Khai Luong, Jonas Korlach, Stephan Heeb, Jörg Overmann, Volkhard Kaever, Susanne Häussler
DNA methylation is widespread among prokaryotes, and most DNA methylation reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction-modification (R-M) systems. R-M systems are known for their role in the defense against foreign DNA; however, DNA methyltransferases also play functional roles in gene regulation. In this study, we used single-molecule real-time (SMRT) sequencing to uncover the genome-wide DNA methylation pattern in the opportunistic pathogen Pseudomonas aeruginosa PAO1...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28222879/evaluation-of-die-trim-morphology-made-by-cad-cam%C3%A2-technology
#20
Pratiksha Agrawal, Geoffrey Thompson, Seok-Hwan Cho, Gerald J Ziebert
STATEMENT OF PROBLEM: The die contour can affect the emergence profile of prosthetic restorations. However, little information is available regarding the congruency between a stereolithographic (SLA) die and its corresponding natural tooth. PURPOSE: The purpose of this vitro study was to evaluate the shapes of SLA die in comparison with the subgingival contour of a prepared tooth to be restored with a ceramic crown. MATERIAL AND METHODS: Twenty extracted human teeth, 10 incisors, and 10 molars, were disinfected and mounted in a typodont model...
February 17, 2017: Journal of Prosthetic Dentistry
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