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https://www.readbyqxmd.com/read/29792920/inner-ear-drug-delivery-recent-advances-challenges-and-perspective
#1
Jinsong Hao, S Kevin Li
Effective and safe treatment of auditory and vestibular diseases has become increasingly dependent on inner ear drug delivery systems. This review highlights recent advances in inner ear drug delivery research and technologies. The focus is on strategies to overcome delivery barriers and to improve drug residence and targeting, with special attention to in vivo animal and human studies. The research in gene and stem cell delivery to the inner ear is briefly reviewed. Newly developed research tools to address experimental challenges and safety issues are discussed...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29792685/vertical-ultrafiltration-facilitated-dna-digestion-for-rapid-and-sensitive-uhplc-ms-ms-detection-of-dna-modifications
#2
Weiyi Lai, Cong Lyu, Hailin Wang
LC-MS/MS technologies provide important and powerful analytical tools for chemical structure-dependent identification and quantification of epigenetically crucial DNA modifications. To perform LC-MS/MS analysis, it is better to convert DNA to 2'-deoxynucleosides through enzymatic digestion. Here, we observed that inorganic cations Na+ and K+ and phosphate buffers, which were often found in various DNA solutions, significantly inhibited DNA digestion as catalyzed by typical set of DNase I, snake venom phosphodiesterase, and calf intestine alkaline phosphatase, leading to poor or varying performance on UHPLC-MS/MS analysis...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792560/acceleration-profile-of-an-acrobatic-act-during-training-and-shows-using-wearable-technology
#3
Leland Barker, Bryan Burnstein, John Mercer
The purpose of this study was to describe the mechanical characteristics of a trampoline circus act and its individual tracks performed in training and shows using a tri-axial accelerometer. A track is an artist's specific role within a choreographed act. Seven male acrobats performed their trampoline act during training and shows while wearing a triaxial accelerometer and reported ratings of perceived exertion (RPE) after each trial. Average acceleration (AVG), root mean square (RMS), root mean to the fourth (RM4), time spent in specific acceleration ranges and RPE were measured/recorded from training and show acts...
May 24, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29792424/comprehensive-investigation-into-luminescent-properties-of-ir-iii-complexes-an-integrated-computational-study-of-radiative-and-nonradiative-decay-processes
#4
Yu Wang, Peng Bao, Jian Wang, Ran Jia, Fu-Quan Bai, Hong-Xing Zhang
A comprehensive and concrete exploration into the deactivation mechanisms of luminescent materials is imperative, with the improvement of simulating and computing technology. In this study, an integrated calculation scheme is employed on five Ir(III) complexes for thorough investigation of their photophysical properties, including radiative ( kr ) and nonradiative ( knr ) decay rates. As a most famous Ir(III) complex with superior quantum efficiency, fac-Ir(ppy)3 herein serves as a reference relative to the other four β-diketonate complexes...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792416/phosphotriesterase-magnetic-nanoparticles-bioconjugates-with-improved-enzyme-activity-in-a-biocatalytic-membrane-reactor
#5
Abaynesh Yihdego Gebreyohannes, Rosalinda Mazzei, Mohamed Yahia Marei Abdelrahim, Giuseppe Vitola, Elena Porzio, Giuseppe Manco, Mihail Barboiu, Lidietta Giorno
The need to find alternative bioremediation solutions for organophosphate degradation pushed the research to develop technologies based on organophosphate degrading enzymes, such as phosphotriesterase. The use of free phosphotriesterase poses limits in terms of enzyme reuse, stability and process development. The heterogenization of enzyme on a support and their use in bioreactors implemented by membrane seems a suitable strategy, thanks to the ability of membranes to compartmentalize, to govern mass transfer and provide microenvironment with tuned physico-chemical and structural properties...
May 24, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29792326/common-principles-of-molecular-electronics-and-nanoscale-electrochemistry
#6
Paulo Roberto Bueno
The merging of nanoscale electronics and electrochemistry can potentially modernize the way electronic devices are currently engineered or constructed. It is well known that the greatest challenges will involve not only miniaturizing and improving the performance of mobile devices, but also manufacturing reliable electrical vehicles, and engineering more efficient solar panels and energy storage systems. These are just a few examples of how technological innovation is dependent on both electrochemical and electronic elements...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29791165/effect-of-polymer-chain-length-on-the-physical-stability-of-amorphous-drug-polymer-blends-at-ambient-pressure
#7
Justyna Pacułt, Marzena Rams-Baron, Beata Chrząszcz, Renata Jachowicz, Marian Paluch
Rational selection of polymers for amorphous drug stabilization is necessary for further successful development of solid dispersion technology. In this paper we investigated the effect of polymer chain length on the inhibition of amorphous drug recrystallization. To consider this problem we prepared a drug-polymer blends (in 10:1 drug to polymer ratio) containing bicalutamide (BIC) and polyvinylpyrrolidone (PVP) with different chain lengths K10, K30, K90. We applied broadband dielectric spectroscopy to compare the molecular dynamics of investigated samples and thoroughly recognize their crystallization tendencies from supercooled liquid state...
May 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29790873/diversity-of-genetic-events-associated-with-mlh1-promoter-methylation-in-lynch-syndrome-families-with-heritable-constitutional-epimutation
#8
Julie Leclerc, Cathy Flament, Tonio Lovecchio, Lucie Delattre, Emilie Ait Yahya, Stéphanie Baert-Desurmont, Nelly Burnichon, Myriam Bronner, Odile Cabaret, Sophie Lejeune, Rosine Guimbaud, Gilles Morin, Jacques Mauillon, Philippe Jonveaux, Pierre Laurent-Puig, Thierry Frébourg, Nicole Porchet, Marie-Pierre Buisine
PurposeConstitutional epimutations are an alternative to genetic mutations in the etiology of genetic diseases. Some of these epimutations, termed secondary, correspond to the epigenetic effects of cis-acting genetic defects transmitted to the offspring following a Mendelian inheritance pattern. In Lynch syndrome, a few families with such apparently heritable MLH1 epimutations have been reported so far.MethodsWe designed a long-range polymerase chain reaction next-generation sequencing strategy to screen MLH1 entire gene and applied it to 4 French families with heritable epimutations and 10 additional patients with no proven transmission of their epimutations...
April 12, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29790856/surface-terminations-of-hematite-i-%C3%AE-i-fe-sub-2-sub-o-sub-3-sub-exposed-to-oxygen-hydrogen-or-water-dependence-on-the-dft-methodology
#9
Richard Baochang Wang, Anders Hellman
Hematite ($\alpha$-Fe$_2$O$_3$) is the most stable and abundant iron oxide
 in nature, and is used in many important environmental and industrial
 technologies, such as waste-water treatment, gas sensors, and
 photoelectrocatalysis. A clear understanding of
 the structure, composition, and chemistry of the hematite surface 
 is crucial for improving its function in these technologies. The (0001) 
 facet is reported to dominate under natural 
 conditions, while the specific terminations depend strongly on
 preparation conditions...
May 23, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29790639/silylarene-hydrogenation-a-strategic-approach-enabling-direct-access-to-versatile-silylated-saturated-carbo-and-heterocycles
#10
Mario Wiesenfeldt, Tobias Knecht, Christoph Schlepphorst, Frank Glorius
Any[Si]ng but flat! We report a method to convert readily available silylated arenes into silylated saturated carbo- and heterocycles by arene hydrogenation. The scope includes alkoxy and halosilyl substituents. Silyl groups can be derivatized into a plethora of functionalities and find application in organic synthesis, materials science, pharmaceutical, agrochemical, and fragrance research. Yet, silylated saturated (hetero- ) cycles are difficult to access with current technologies. The yield of the hydrogenation depends on the amount of the silica gel additive...
May 23, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29790042/orthopaedic-regenerative-tissue-engineering-en-route-to-the-holy-grail-disequilibrium-between-the-demand-and-the-supply-in-the-operating-room
#11
REVIEW
Ibrahim Fatih Cengiz, Hélder Pereira, Laura de Girolamo, Magali Cucchiarini, João Espregueira-Mendes, Rui L Reis, Joaquim Miguel Oliveira
Orthopaedic disorders are very frequent, globally found and often partially unresolved despite the substantial advances in science and medicine. Their surgical intervention is multifarious and the most favourable treatment is chosen by the orthopaedic surgeon on a case-by-case basis depending on a number of factors related with the patient and the lesion. Numerous regenerative tissue engineering strategies have been developed and studied extensively in laboratory through in vitro experiments and preclinical in vivo trials with various established animal models, while a small proportion of them reached the operating room...
May 22, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29789573/high-throughput-screening-of-prostate-cancer-risk-loci-by-single-nucleotide-polymorphisms-sequencing
#12
Peng Zhang, Ji-Han Xia, Jing Zhu, Ping Gao, Yi-Jun Tian, Meijun Du, Yong-Chen Guo, Sufyan Suleman, Qin Zhang, Manish Kohli, Lori S Tillmans, Stephen N Thibodeau, Amy J French, James R Cerhan, Li-Dong Wang, Gong-Hong Wei, Liang Wang
Functional characterization of disease-causing variants at risk loci has been a significant challenge. Here we report a high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) technology to simultaneously screen hundreds to thousands of SNPs for their allele-dependent protein-binding differences. This technology takes advantage of higher retention rate of protein-bound DNA oligos in protein purification column to quantitatively sequence these SNP-containing oligos. We apply this technology to test prostate cancer-risk loci and observe differential allelic protein binding in a significant number of selected SNPs...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29788319/participatory-design-in-gerontechnology-a-systematic-literature-review
#13
Sebastian Merkel, Alexander Kucharski
Purpose of the Study: Participatory design (PD) is widely used within gerontechnology but there is no common understanding about which methods are used for what purposes. This review aims to examine what different forms of PD exist in the field of gerontechnology and how these can be categorized. Design and Methods: We conducted a systematic literature review covering several databases. The search strategy was based on 3 elements: (1) participatory methods and approaches with (2) older persons aiming at developing (3) technology for older people...
May 19, 2018: Gerontologist
https://www.readbyqxmd.com/read/29788179/normative-data-for-the-btracks-balance-test-of-postural-sway-results-from-16-357-community-dwelling-individuals-who-were-5-to-100-years-old
#14
Daniel J Goble, Harsimran S Baweja
Background: Postural sway is routinely assessed because increased postural sway is associated with poorer performance of activities of daily living, higher rates of residential care, and increased risk of falling. Force plate technology is one of the most sensitive and objective means of assessing postural sway in the clinic. Objective: The aim of this study was to provide the first set of normative data for the BTrackS Balance Test (BBT) of postural sway. Design: The design was descriptive and population based...
May 17, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29787568/using-discursis-to-enhance-the-qualitative-analysis-of-hospital-pharmacist-patient-interactions
#15
Bernadette A M Chevalier, Bernadette M Watson, Michael A Barras, William N Cottrell, Daniel J Angus
INTRODUCTION: Pharmacist-patient communication during medication counselling has been successfully investigated using Communication Accommodation Theory (CAT). Communication researchers in other healthcare professions have utilised Discursis software as an adjunct to their manual qualitative analysis processes. Discursis provides a visual, chronological representation of communication exchanges and identifies patterns of interactant engagement. AIM: The aim of this study was to describe how Discursis software was used to enhance previously conducted qualitative analysis of pharmacist-patient interactions (by visualising pharmacist-patient speech patterns, episodes of engagement, and identifying CAT strategies employed by pharmacists within these episodes)...
2018: PloS One
https://www.readbyqxmd.com/read/29787513/real-time-ultrasound-assisted-gluteal-fat-grafting
#16
Alvaro Luiz Cansancao, Alexandra Condé-Green, Rafael A Vidigal, Ricardo Luis Rodriguez, Richard A D'Amico
BACKGROUND: Outcomes in primary breast augmentation depend on careful preoperative planning and clear communication between patient and surgeon. Three-dimensional imaging with computer simulation is an evolving technology with the potential to enhance the preoperative consultation for patients considering primary breast augmentation. The purpose of this study was to prospectively evaluate the impact of three-dimensional imaging with computer simulation on patient-reported and objective, mammometric outcomes in women undergoing primary breast augmentation...
May 16, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29787414/perioperative-peripheral-nerve-injury-after-general-anesthesia-a-qualitative-systematic-review
#17
Jason Chui, John M Murkin, Karen L Posner, Karen B Domino
Perioperative peripheral nerve injury (PNI) is a well-recognized complication of general anesthesia that continues to result in patient disability and malpractice claims. However, the multifactorial etiology of PNI is often not appreciated in malpractice claims given that most PNI is alleged to be due to errors in patient positioning. New advances in monitoring may aid anesthesiologists in the early detection of PNI. This article reviews recent studies of perioperative PNI after general anesthesia and discusses the epidemiology and potential mechanisms of injury and preventive measures...
May 21, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29786789/protocols-for-tissue-microarrays-in-prostate-cancer-studies
#18
Tatjana Vlajnic, Serenella Eppenberger-Castori, Lukas Bubendorf
Tissue microarray (TMA) technology is a method for high-throughput analysis of tissue biomarkers, commonly used in translational cancer research. TMAs allow performing a variety of in situ applications on hundreds of tissue samples simultaneously using the same protocols as for conventional slides. Thereby, precious material from patient samples remains largely preserved while costs in resources and time in laboratory processing decrease. Therefore, a TMA is a powerful tool to identify and study biomarkers that may have a potential diagnostic, prognostic, and predictive value...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29786632/influences-of-playing-position-and-quality-of-opposition-on-standardized-relative-distance-covered-in-domestic-women-s-field-hockey-implications-for-coaches
#19
Don Vinson, Nicola Gerrett, David V B James
Vinson, D, Gerrett, N, and James, DVB. Influences of playing position and quality of opposition on standardized relative distance covered in domestic women's field hockey: Implications for coaches. J Strength Cond Res 32(6): 1770-1777, 2018-The purpose of this study was to compare the standardized relative distance covered by the various playing positions (defenders, midfielders, and forwards) against different quality of opponents in domestic women's field hockey. Data were collected from 13 individuals competing for 1 team in the English Premier League across an 18-game season...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786562/application-of-hepatocyte-like-cells-to-enhance-hepatic-safety-risk-assessment-in-drug-discovery
#20
REVIEW
Dominic P Williams
Hepatic stress and injury from drugs continues to be a major concern within the pharmaceutical industry, leading to preclinical and clinical attrition precautionary warnings and post-market withdrawal of drugs. There is a requirement for more predictive and mechanistically accurate models to aid risk assessment. Primary human hepatocytes, subject to isolation stress, cryopreservation, donor-to-donor variation and a relatively short period of functional capability in two-dimensional cultures, are not suitable for high-throughput screening procedures...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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