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https://www.readbyqxmd.com/read/28738331/future-perspectives-in-sleep-medicine
#1
Leh-Kiong Anne Huon, Christian Guilleminault
"Sleep Medicine" is now a specialty in its own right. Currently, there is increasing recognition of the very negative impact sleep disorders have on learning, education, safety, and quality of life. Technological advances will help us to break down diagnoses (e.g., narcolepsy has now been subdivided into types 1 and 2, depending upon the hypocretin levels in the spinal fluid) and to discover relationships to other bodily systems (e.g., type 1 narcolepsy potentially being an autoimmune disorder). The modern lifestyle of many, as characterized by a shortening of sleep periods, shift work, jet lag, and the need to be constantly available, means that advances in sleep medicine may result in a major understanding of more balanced "work-rest lifestyle" modifications...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738313/high-throughput-phenotyping-to-accelerate-crop-breeding-and-monitoring-of-diseases-in-the-field
#2
REVIEW
Nadia Shakoor, Scott Lee, Todd C Mockler
Effective implementation of technology that facilitates accurate and high-throughput screening of thousands of field-grown lines is critical for accelerating crop improvement and breeding strategies for higher yield and disease tolerance. Progress in the development of field-based high throughput phenotyping methods has advanced considerably in the last 10 years through technological progress in sensor development and high-performance computing. Here, we review recent advances in high throughput field phenotyping technologies designed to inform the genetics of quantitative traits, including crop yield and disease tolerance...
July 21, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28738283/visual-and-reversible-carbon-dioxide-sensing-enabled-by-doctor-blade-coated-macroporous-photonic-crystals
#3
Yi-Han Lin, Shing-Yi Suen, Hongta Yang
With significant impacts of carbon dioxide on global climate change, carbon dioxide sensing is of great importance. However, most of the existing sensing technologies are prone to interferences from carbon monoxide, or suffer from the use of sophisticated instruments. This research reports the development of reproducible carbon dioxide sensor using roll-to-roll compatible doctor blade coated three-dimensional macroporous photonic crystals. The pores are functionalized with amine groups to allow the reaction with carbon dioxide in the presence of humidity...
July 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28736308/laminar-fmri-what-can-the-time-domain-tell-us
#4
REVIEW
Natalia Petridou, Jeroen C W Siero
The rapid developments in functional MRI (fMRI) acquisition methods and hardware technologies in recent years, particularly at high field (≥7 T), have enabled unparalleled visualization of functional detail at a laminar or columnar level, bringing fMRI close to the intrinsic resolution of brain function. These advances highlight the potential of high resolution fMRI to be a valuable tool to study the fundamental processing performed in cortical micro-circuits, and their interactions such as feedforward and feedback processes...
July 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28735883/permeability-modes-in-fluctuating-lipid-membranes-with-dna-translocating-pores
#5
REVIEW
L H Moleiro, M Mell, R Bocanegra, I López-Montero, P Fouquet, Th Hellweg, J L Carrascosa, F Monroy
Membrane pores can significantly alter not only the permeation dynamics of biological membranes but also their elasticity. Large membrane pores able to transport macromolecular contents represent an interesting model to test theoretical predictions that assign active-like (non-equilibrium) behavior to the permeability contributions to the enhanced membrane fluctuations existing in permeable membranes [Maneville et al. Phys. Rev. Lett. 82, 4356 (1999)]. Such high-amplitude active contributions arise from the forced transport of solvent and solutes through the open pores, which becomes even dominant at large permeability...
July 16, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28735487/targeted-next-generation-sequencing-of-acute-leukemia
#6
Eric Konnick, Christina M Lockwood, David Wu
Mutation profiling of acute leukemias is a valuable tool for identifying genetic mutations with prognostic, predictive, therapeutic, and diagnostic utility. Technological advances, such as massively parallel sequencing, have allowed laboratories to assess for variation across dozens or hundreds of genes simultaneously with relatively low cost per target.Here, we describe a procedure for designing and using a TruSeq Custom Amplicon assay targeting genes involved in acute leukemias. This method is a fully customizable, amplicon-based assay for targeted resequencing, allowing interrogation of selected genomic regions of interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28734678/improvement-of-adipose-tissue-derived-cells-by-low-energy-extracorporeal-shock-wave-therapy
#7
Eleni Priglinger, Christina M A P Schuh, Carolin Steffenhagen, Christoph Wurzer, Julia Maier, Sylvia Nuernberger, Wolfgang Holnthoner, Christiane Fuchs, Susanne Suessner, Dominik Rünzler, Heinz Redl, Susanne Wolbank
BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency...
July 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28734631/sexting-and-the-definition-issue
#8
REVIEW
Yara Barrense-Dias, André Berchtold, Joan-Carles Surís, Christina Akre
Sexting among youths has become a necessary topic of interest in research because of the negative consequences that this activity could create, especially when content is shared with others. Indeed, this loss of control could lead to humiliation, (cyber)bullying, or harassment. The development of new technologies, press coverage, and increase of prevalence rates could also explain the growth of interest in sexting. However, its definition is still a gray area. This review examines the different definitions of sexting used in the literature and its correlates...
July 19, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28733862/recommendations-for-systematic-statistical-computation-of-immunogenicity-cut-points
#9
Viswanath Devanarayan, Wendell C Smith, Rocco L Brunelle, Mary E Seger, Kim Krug, Ronald R Bowsher
Today, the assessment of immunogenicity is integral in nonclinical and clinical testing of new biotherapeutics and biosimilars. A key component in the risk-based evaluation of immunogenicity involves the detection and characterization of anti-drug antibodies (ADA). Over the past couple of decades, much progress has been made in standardizing the generalized approach for ADA testing with a three-tiered testing paradigm involving screening, confirmation, and quasi-quantitative titer assessment representing the typical harmonized scheme...
July 21, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28732554/microbial-ecology-and-process-technology-of-sourdough-fermentation
#10
Luc De Vuyst, Simon Van Kerrebroeck, Frédéric Leroy
From a microbiological perspective, sourdough is to be considered as a specific and stressful ecosystem, harboring yeasts and lactic acid bacteria (LAB), that is used for the production of baked goods. With respect to the metabolic impact of the sourdough microbiota, acidification (LAB), flavor formation (LAB and yeasts), and leavening (yeasts and heterofermentative LAB species) are most noticeable. Three distinct types of sourdough fermentation processes can be discerned based on the inocula applied, namely backslopped ones (type 1), those initiated with starter cultures (type 2), and those initiated with a starter culture followed by backslopping (type 3)...
2017: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/28732459/crispulator-a-discrete-simulation-tool-for-pooled-genetic-screens
#11
Tamas Nagy, Martin Kampmann
BACKGROUND: The rapid adoption of CRISPR technology has enabled biomedical researchers to conduct CRISPR-based genetic screens in a pooled format. The quality of results from such screens is heavily dependent on the selection of optimal screen design parameters, which also affects cost and scalability. However, the cost and effort of implementing pooled screens prohibits experimental testing of a large number of parameters. RESULTS: We present CRISPulator, a Monte Carlo method-based computational tool that simulates the impact of screen parameters on the robustness of screen results, thereby enabling users to build intuition and insights that will inform their experimental strategy...
July 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28732267/understanding-the-holobiont-the-interdependence-of-plants-and-their-microbiome
#12
REVIEW
Carmen Sánchez-Cañizares, Beatriz Jorrín, Philip S Poole, Andrzej Tkacz
The holobiont is composed by the plant and its microbiome. In a similar way to ecological systems of higher organisms, the holobiont shows interdependent and complex dynamics [1,2]. While plants originate from seeds, the microbiome has a multitude of sources. The assemblage of these communities depends on the interaction between the emerging seedling and its surrounding environment, with soil being the main source. These microbial communities are controlled by the plant through different strategies, such as the specific profile of root exudates and its immune system...
July 18, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28732117/identification-by-phenotypic-and-genetic-approaches-of-an-indigenous-saccharomyces-cerevisiae-wine-strain-with-high-desiccation-tolerance
#13
Marianna Zambuto, Rossana Romaniello, Nicoletta Guaragnella, Patrizia Romano, Sonia Votta, Angela Capece
During active dry yeast (ADY) production process, cells are exposed to multiple stresses, such as thermal, oxidative and hyperosmotic shock. Previously, by analyzing cells in exponential growth phase, we selected an indigenous Saccharomyces cerevisiae wine strain, namely CD-6Sc, for its higher tolerance to desiccation and higher expression of specific desiccation stress-related genes in comparison to other yeast strains. In this study, we performed a desiccation treatment on stationary phase cells by comparing the efficacy of two different methods: a "laboratory dry test" in a small-scale (mild stress) and a treatment by spray-drying (severe stress), one of the most appropriate preservation method for yeasts and other micro-organisms...
July 21, 2017: Yeast
https://www.readbyqxmd.com/read/28732074/who-uses-running-apps-and-sports-watches-determinants-and-consumer-profiles-of-event-runners-usage-of-running-related-smartphone-applications-and-sports-watches
#14
Mark Janssen, Jeroen Scheerder, Erik Thibaut, Aarnout Brombacher, Steven Vos
Individual and unorganized sports with a health-related focus, such as recreational running, have grown extensively in the last decade. Consistent with this development, there has been an exponential increase in the availability and use of electronic monitoring devices such as smartphone applications (apps) and sports watches. These electronic devices could provide support and monitoring for unorganized runners, who have no access to professional trainers and coaches. The purpose of this paper is to gain insight into the characteristics of event runners who use running-related apps and sports watches...
2017: PloS One
https://www.readbyqxmd.com/read/28732059/ecis-technology-reveals-that-monocytes-isolated-by-cd14-ve-selection-mediate-greater-loss-of-bbb-integrity-than-untouched-monocytes-which-occurs-to-a-greater-extent-with-il-1%C3%AE-activated-endothelium-in-comparison-to-tnf%C3%AE
#15
Dan Ting Kho, Rebecca Johnson, Laverne Robilliard, Elyce du Mez, Julie McIntosh, Simon J O'Carroll, Catherine E Angel, E Scott Graham
BACKGROUND: We have previously shown that TNFα and IL-1β differentially regulate the inflammatory phenotype of human brain endothelial cells (hCMVECs). In this regard, IL-1β treatment was considerably more potent than TNFα at increasing expression of inflammatory chemokines and leukocyte adhesion molecules. We therefore hypothesised that interaction of the hCMVECs with human monocytes would also be dependent on the activation status of the endothelium. Therefore, the primary aim of this study was to assess whether brain endothelial cells activated by IL-1β or TNFα differed in their interaction with monocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28731614/economic-injury-levels-and-economic-thresholds-for-leptoglossus-zonatus-dallas-hemiptera-coreidae-infesting-seed-maize
#16
Josemar Foresti, Cristina S Bastos, Flávio L Fernandes, Paulo R da Silva
BACKGROUND: Although Leptoglossus zonatus is considered a secondary pest of maize grown for grain, when grown for seed, this pest can cause significant economic damage. There are no records of management recommendations for this pest. The objectives of this work were to quantify losses caused by L. zonatus to different genotypes used for seed maize production and to estimate the acute toxicity of select insecticides to L. zonatus using different application technologies. The ultimate goal was to calculate economic injury levels (EILs) and develop economic thresholds (ETs) for L...
July 21, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28731355/luminescent-fire-resistant-and-water-proof-ultralong-hydroxyapatite-nanowire-based-paper-for-multimode-anticounterfeiting-applications
#17
Ri-Long Yang, Ying-Jie Zhu, Fei-Fei Chen, Li-Ying Dong, Zhi-Chao Xiong
Counterfeiting of valuable certificates, documents, and banknotes is a serious issue worldwide. As a result, the need for developing novel anticounterfeiting materials is greatly increasing. Herein, we report a new kind of ultralong hydroxyapatite nanowire (HAPNW)-based paper with luminescence, fire resistance, and waterproofness properties that may be exploited for anticounterfeiting applications. In this work, lanthanide-ion-doped HAPNWs (HAPNW:Ln(3+)) with lengths over 100 μm have been synthesized and used as a raw material to fabricating a free-standing luminescent, fire-resistant, water-proof paper through a simple vacuum filtration process...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28730811/atomic-mechanism-of-hybridization-dependent-surface-reconstruction-with-tailored-functionality-in-hexagonal-multiferroics
#18
Shiqing Deng, Shaobo Cheng, Changsong Xu, Binghui Ge, Xuefeng Sun, Rong Yu, Wenhui Duan, Jing Zhu
The broken symmetry along with anomalous defect structures and charging conditions at multiferroics surface can alter both crystal structures and electronic configurations, bringing in emergent physical properties. Extraordinary surface states are induced into original mutually-coupled order parameters in such strongly correlated oxides, which flourish in diverse properties, however remain less explored. Here, we report the peculiar surface ferroelectric states and reconfigurable functionalities driven by the relaxation of surface and consequent changes in O-2p and Y-4d orbital (p-d) hybridization within a representative hexagonal multiferroics YMnO3...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28729521/influence-of-block-copolymer-feature-size-on-reactive-ion-etching-pattern-transfer-into-silicon
#19
Masoud Dialameh, Federico Ferrarese Lupi, Dario Imbraguglio, Fabio Zanenga, Alessio Lamperti, Davide Martella, Gabriele Seguini, Michele Perego, Andrea Mario Rossi, Natascia De Leo, Luca Boarino
A successful realization of sub 20 nm features on silicon is becoming the focus of many technological studies, strongly influencing the future performance of modern integrated circuits. Although reactive ion etching (RIE), at both micrometric and nanometric scale has already been the target of many studies, a better understanding of the different mechanisms involved at sub 20 nm size etching is still required. In this work, we investigated the influence of the feature size on etch rate of silicon, performed by Cryogenic RIE process through cylinder-forming polystyrene-block-polymethilmetacrhlate (PS-b-PMMA) DiBlock Copolymers (DBCs) masks with diameter ranging between 19 and 13 nm...
July 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28729303/amotosalen-uva-pathogen-inactivation-technology-reduces-platelet-activatability-induces-apoptosis-and-accelerates-clearance
#20
Simona Stivala, Sara Gobbato, Laura Infanti, Martin F Reiner, Nicole Bonetti, Sara C Meyer, Giovanni G Camici, Thomas F Lüscher, Andreas Buser, Jürg H Beer
Amotosalen and ultraviolet A photochemical-based pathogen reduction using the InterceptTM Blood System is an effective and established technology for platelet and plasma components, which is adopted in more than 40 countries worldwide. Several reports point towards a reduced platelet function after Amotosalen/UVA exposure. The current study was undertaken to identify the mechanisms responsible for the early impairment of platelet function by the InterceptTM Blood System. Twenty-five platelet apheresis units were collected from healthy volunteers following standard procedures and split into 2 components, one untreated and the other treated with Amotosalen/UVA...
July 20, 2017: Haematologica
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