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Osteoporosis primary biliary cirrhosis

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https://www.readbyqxmd.com/read/27261902/metabolic-bone-disease-in-primary-biliary-cirrhosis
#1
REVIEW
Lisa M Glass, Grace Li-Chun Su
Primary biliary cirrhosis (PBC) is a liver-specific autoimmune disease that primarily affects women (female-to-male ratio, 10:1) between 40 and 60 years of age. Metabolic bone disease is a common complication of PBC, affecting 14% to 52% of patients, depending on the duration and severity of liver disease. The osteoporosis seen in PBC seems mainly due to low bone formation, although increased bone resorption may contribute. Treatment of osteoporosis consists primarily of antiresorptive agents. Additional large prospective, long-term studies in patients with PBC are needed to determine efficacy in improving bone density as well as reducing fracture risk...
June 2016: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/26842849/a-common-variant-in-cldn14-is-associated-with-primary-biliary-cirrhosis-and-bone-mineral-density
#2
Ruqi Tang, Yiran Wei, Zhiqiang Li, Haoyan Chen, Qi Miao, Zhaolian Bian, Haiyan Zhang, Qixia Wang, Zhaoyue Wang, Min Lian, Fan Yang, Xiang Jiang, Yue Yang, Enling Li, Michael F Seldin, M Eric Gershwin, Wilson Liao, Yongyong Shi, Xiong Ma
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone mineral density (BMD). These observations led us to investigate the genetic variants shared between PBC and BMD. We evaluated 72 genome-wide significant BMD SNPs for association with PBC using two European GWAS data sets (n = 8392), with replication of significant findings in a Chinese cohort (685 cases, 1152 controls)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26554665/a-case-of-severe-osteomalacia-caused-by-tubulointerstitial-nephritis-with-fanconi-syndrome-in-asymptomotic-primary-biliary-cirrhosis
#3
Shintaro Yamaguchi, Tatsuya Maruyama, Shu Wakino, Hirobumi Tokuyama, Akinori Hashiguchi, Shinichiro Tada, Koichiro Homma, Toshiaki Monkawa, James Thomas, Kazutoshi Miyashita, Isao Kurihara, Tadashi Yoshida, Konosuke Konishi, Koichi Hayashi, Matsuhiko Hayashi, Hiroshi Itoh
BACKGROUND: Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease, characterized by increased concentrations of serum IgM and the presence of circulating anti-mitochondrial antibodies. Although bone diseases such as osteoporosis or osteodystrophy are commonly associated with PBC, osteomalacia which is caused by abnormal vitamin D metabolism, mineralization defects, and phosphate deficiency has not been recognized as a complication of PBC. CASE PRESENTATION: We report the case of a 49-year-old Japanese woman who complained of multiple fractures...
2015: BMC Nephrology
https://www.readbyqxmd.com/read/26503873/-clinical-guidelines-for-bone-disease-in-primary-biliary-cirrhosis
#4
Hiromi Ishibashi, Atsumasa Komori
Primary biliary cirrhosis(PBC)is a chronic cholestatic liver disease and the association of osteoporosis is high. In this paper, the practical guidelines for PBC of Japan as well as those of America(AASLD)and Europe(EASL)are mentioned. Description of each guideline is essentially the same;taking sufficient calcium(1,000~1,200 mg/day)with vitamin D and weight-bearing exercise, and thereafter medication such as alendronate is recommended.
November 2015: Clinical Calcium
https://www.readbyqxmd.com/read/26503867/-bone-disease-in-primary-biliary-cirrhosis
#5
Hidetaka Shibata, Kazuhiko Nakao
Primary biliary cirrhosis(PBC)is a chronic autoimmune cholestatic liver disease. Metabolic bone disease is recognized in a complication of chronic liver disease, particularly in PBC. Bone disease in PBC includes osteoporosis and, osteomalacia which is more frequent in advanced liver disease. It is important that PBC occurs mainly in middle-aged women who are highest risk group in primary osteoporosis. In patients with PBC, the dysfunction in enterohepatic circulation of bile acids is associated with the impaired absorption of fats and fat soluble vitamins...
November 2015: Clinical Calcium
https://www.readbyqxmd.com/read/26503865/-bone-complications-in-chronic-liver-disease-hepatic-osteodystrophy
#6
REVIEW
Hisanori Suzuki
Bone complication occurs in patients with alcoholic hepatitis, chronic hepatitis C, primary biliary cirrhosis(PBC), primary sclerosing cholangitis(PSC)or post liver transplant. Prevalence of osteoporosis and fracture risk is high in these diseases. Nonalcoholic fatty liver disease(NAFLD)and non-alcoholic steatohepatitis(NASH)is increasing in prevalence. Relation of NAFLD/NASH with osteoporosis, however, is not well known, and further investigation is needed.
November 2015: Clinical Calcium
https://www.readbyqxmd.com/read/25972904/the-impact-of-fragility-fractures-on-health-related-quality-of-life-in-patients-with-primary-sclerosing-cholangitis
#7
Joanna Raszeja-Wyszomirska, Robert Kucharski, Marta Zygmunt, Krzysztof Safranow, Tomasz Miazgowski
BACKGROUND: Osteoporosis occurs frequently in patients with chronic cholestatic liver diseases, yet data are scarce regarding the prevalence of osteoporosis and fragility fractures and their impact on Health-Related Quality of Life (HRQoL) in Primary Sclerosing Cholangitis (PSC). OBJECTIVES: We aimed to assess Bone Mineral Density (BMD), physical activity and incidence of fragility fractures in patients with PSC. We also sought associations between prior fractures and HRQoL...
April 2015: Hepatitis Monthly
https://www.readbyqxmd.com/read/25954476/primary-biliary-cirrhosis-pathophysiology-clinical-presentation-and-therapy
#8
REVIEW
Treta Purohit, Mitchell S Cappell
Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver disease characterized by a triad of chronic cholestasis, circulating anti-mitochondrial antibodies (AMA), and characteristic liver biopsy findings of nonsuppurative destructive cholangitis and interlobular bile duct destruction. About 10% of PBC patients, however, lack AMA. A variant, called PBC-autoimmune hepatitis (AIH) overlap, is characterized by the above findings of PBC together with findings of elevated serum alanine aminotransferase, elevated serum immunoglobulin G, and circulating anti-smooth muscle antibodies, with liver biopsy demonstrating periportal or periseptal, lymphocytic, piecemeal necrosis...
May 8, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25568651/hepatic-osteodystrophy
#9
REVIEW
Angelo Gatta, Alberto Verardo, Marco Di Pascoli, Sandro Giannini, Massimo Bolognesi
Metabolic disturbances of bone are frequent in patients with chronic liver disease. The prevalence of osteoporosis among patients with advanced chronic liver disease is reported between 12% and 55%; it is higher in primary biliary cirrhosis. All patients with advanced liver disease should be screened for osteoporosis with a densitometry, especially if the etiology is cholestatic and in the presence of other risk factors. Clinical relevance of hepatic osteodystrophy increases after liver transplantation. After liver transplant, a rapid loss of bone mineral density can be detected in the first 6 months, followed by stabilization and slight improvement of the values...
September 2014: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/25061487/osteoporosis-in-primary-biliary-cirrhosis-of-the-liver
#10
REVIEW
Joanna Raszeja-Wyszomirska, Tomasz Miazgowski
Osteoporosis is a metabolic bone disease associated with a reduction in bone mass and deterioration of bone architecture, leading to increased fragility and subsequent low-trauma fractures in the vertebral column, hip, forearm and other bones. In literature, metabolic bone diseases such as osteoporosis and osteomalacia have been recognised as a complication of chronic liver disease, although the mechanisms of this association remain unclear. An increasing body of research data indicates a strong relationship between osteoporosis and primary biliary cirrhosis (PBC), which mainly results from early diagnosis of the disease, usually when it is still asymptomatic...
2014: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/25057957/old-and-novel-therapies-for-primary-biliary-cirrhosis
#11
REVIEW
Albert Parés
Despite the presumed immunological pathogenesis of primary biliary cirrhosis, no clear or even harmful consequences resulted from some specific treatments addressed to modify the immunological condition. However, ursodeoxycholic acid (UDCA; 13-16 mg/kg/d) has clear favorable effects not only by improving biochemical cholestasis, but also by delaying the histological progression. Long -term treatment with UDCA is associated with excellent survival, free of transplantation in cases showing biochemical response at one year...
August 2014: Seminars in Liver Disease
https://www.readbyqxmd.com/read/24969292/primary-sclerosing-cholangitis
#12
REVIEW
Kate D Williamson, Roger W Chapman
Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. It is a progressive disorder which can ultimately lead to biliary cirrhosis, portal hypertension and hepatic failure. PSC is a complex genetic disorder with male predominance. Environmental predisposing factors include non-smoking. It is closely associated with inflammatory bowel disease (IBD), particularly ulcerative colitis, which occurs in about two thirds of PSC cases...
2014: Digestive Diseases
https://www.readbyqxmd.com/read/23959535/strengthening-the-bones-in-primary-biliary-cirrhosis
#13
EDITORIAL
Paul Angulo
No abstract text is available yet for this article.
December 2013: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/23686738/randomized-trial-comparing-monthly-ibandronate-and-weekly-alendronate-for-osteoporosis-in-patients-with-primary-biliary-cirrhosis
#14
RANDOMIZED CONTROLLED TRIAL
Núria Guañabens, Anna Monegal, Dacia Cerdá, África Muxí, Laia Gifre, Pilar Peris, Albert Parés
UNLABELLED: Osteoporosis resulting in bone fractures is a complication in patients with primary biliary cirrhosis (PBC). Once-weekly alendronate improves bone mass and is well tolerated in these patients, but there is a concern because of poor compliance. Therefore, the efficacy, adherence, and safety of monthly ibandronate (150 mg) with weekly alendronate (70 mg) were compared in a randomized, 2-year study in 42 postmenopausal women with PBC and osteoporosis. Bone mineral density (BMD) of the lumbar spine and proximal femur (by DXA), liver function, and bone markers were measured at entry and every 6 months over 2 years...
December 2013: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/22988822/celiac-disease-arthropathy-and-autoimmunity-study
#15
Tariq Iqbal, Mukarram A Zaidi, George A Wells, Jacob Karsh
BACKGROUND AND AIM: To evaluate presence of sero-negative spondyloarthritis (SpA) in celiac disease (CD) patients, and whether compliance with a gluten free diet (GFD) improved arthritis manifestations in these patients. METHODS: We undertook a prospective, questionnaire based, cross-sectional cohort study to evaluate the presence or absence of SpA simultaneously in both CD and non-CD cohorts. RESULTS: 356/590 (60.3%) patients with CD participated in this study...
January 2013: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/22841194/prevalence-and-characteristics-of-bone-disease-in-cirrhotic-patients-under-evaluation-for-liver-transplantation
#16
A Alcalde Vargas, J M Pascasio Acevedo, I Gutiérrez Domingo, R García Jiménez, J M Sousa Martín, M T Ferrer Ríos, M Sayago Mota, A Giráldez Gallego, M A Gómez Bravo
BACKGROUND: We performed a retrospective study to examine the prevalence of bone disease (BD) among cirrhotic patients being evaluated for liver transplantation (OLT) using bone densitometry dual-energy x-ray absorptiometry in the hip/femoral neck and lumbar spine. The associations of BD with demographic and clinical data, disease etiology and liver function were studied by univariate and multivariate logistic regression analyses. Osteopenia and osteoporosis were defined by World Health Organization criteria...
July 2012: Transplantation Proceedings
https://www.readbyqxmd.com/read/22216370/hepatic-osteodystrophy-an-important-matter-for-consideration-in-chronic-liver-disease
#17
Germán López-Larramona, Alfredo J Lucendo, Sonia González-Castillo, José M Tenias
Hepatic osteodystrophy (HO) is the generic term defining the group of alterations in bone mineral metabolism found in patients with chronic liver disease. This paper is a global review of HO and its main pathophysiological, epidemiological and therapeutic aspects. Studies examining the most relevant information concerning the prevalence, etiological factors, diagnostic and therapeutic aspects involved in HO were identified by a systematic literature search of the PubMed database. HO generically defines overall alterations in bone mineral density (BMD) (osteoporosis or osteopenia) which appear as a possible complication of chronic liver disease...
December 27, 2011: World Journal of Hepatology
https://www.readbyqxmd.com/read/22161447/hormone-replacement-for-osteoporosis-in-women-with-primary-biliary-cirrhosis
#18
REVIEW
Jelena S Rudic, Goran Poropat, Miodrag N Krstic, Goran Bjelakovic, Christian Gluud
BACKGROUND: Women with primary biliary cirrhosis often suffer from postmenopausal osteoporosis due to their age, or osteoporosis secondary to their liver disease, or treatments provided for their liver disease. Hormone replacement increases bone mineral density and reduces fractures in postmenopausal women. On the other hand, hormone replacement increases the risk of various adverse events. We could not identify any meta-analyses or systematic reviews on hormone replacement in women with primary biliary cirrhosis...
2011: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22161446/bisphosphonates-for-osteoporosis-in-primary-biliary-cirrhosis
#19
REVIEW
Jelena S Rudic, Vanja Giljaca, Miodrag N Krstic, Goran Bjelakovic, Christian Gluud
BACKGROUND: Bisphosphonates are widely used for treatment of postmenopausal osteoporosis. Patients with primary biliary cirrhosis often have osteoporosis - either postmenopausal or secondary to the liver disease. No systematic review or meta-analysis has assessed the effects of bisphosphonates for osteoporosis in patients with primary biliary cirrhosis. OBJECTIVES: To assess the beneficial and harmful effects of bisphosphonates for osteoporosis in primary biliary cirrhosis...
2011: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22120908/de-novo-autoimmune-hepatitis-associated-with-pth-1-34-and-pth-1-84-administration-for-severe-osteoporosis-in-a-liver-transplant-patient
#20
P Anagnostis, Z A Efstathiadou, E Akriviadis, P Hytiroglou, M Kita
De novo autoimmune hepatitis (AIH) is a rare graft dysfunction occurring in patients having undergone liver transplantation (LT) for causes other than AIH. We describe for the first time a case of de novo AIH associated with the administration of parathyroid hormone 1-34 [PTH(1-34)] and PTH(1-84) for severe osteoporosis. A 61-year-old woman was referred to our metabolic bone clinic due to severe osteoporosis, 3 years after LT for primary biliary cirrhosis. Initial treatment with PTH(1-34) led to asymptomatic hypertransaminasemia (two-fold the upper limit of normal), which normalized after drug discontinuation...
September 2012: Osteoporosis International
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