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https://www.readbyqxmd.com/read/29733679/infant-viral-respiratory-infection-nasal-immune-response-patterns-and-their-association-with-subsequent-childhood-recurrent-wheeze
#1
Kedir N Turi, Jyoti Shankar, Larry J Anderson, Devi Rajan, Kelsey Gaston, Tebeb Gebretsadik, Suman R Das, Cosby Stone, Emma K Larkin, Christian Rosas-Salazar, Steven M Brunwasser, Martin L Moore, R Stokes Peebles, Tina V Hartert
RATIONALE: Recurrent wheeze and asthma are thought to result from alterations in early life immune development following RSV infection, however, prior studies of the nasal immune-response to infection have assessed only individual cytokines, which doesn't capture the whole spectrum of response to infection. OBJECTIVE: To identify nasal immune phenotypes in response to RSV infection and their association with recurrent wheeze. METHODS: A birth cohort of term healthy infants born June-December were recruited and followed to capture the first infant RSV infection...
May 7, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29677587/effects-of-chronic-exposure-to-cadmium-and-temperature-alone-or-combined-on-the-threespine-stickleback-gasterosteus-aculeatus-interest-of-digestive-enzymes-as-biomarkers
#2
Younes Mohamed Ismail Hani, Cyril Turies, Olivier Palluel, Laurence Delahaut, Véronique Gaillet, Anne Bado-Nilles, Jean-Marc Porcher, Alain Geffard, Odile Dedourge-Geffard
The development of predictive, sensitive and reliable biomarkers is of crucial importance for aquatic biomonitoring to assess the effects of chemical substances on aquatic organisms, especially when it comes to combined effects with other stressors (e.g. temperature). The first purpose of the present study was to evaluate the single and combined effects of 90 days of exposure to an environmental cadmium concentration (0.5 μg L-1 ) and two water temperatures (16 and 21 °C) on different parameters. These parameters are involved in (i) the antioxidant system (superoxide dismutase activity -SOD- and total glutathione levels -GSH-), (ii) the energy metabolism, i...
April 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29672569/on-ways-to-overcome-the-magical-capacity-limit-of-working-memory
#3
Zsolt Turi, Ivan Alekseichuk, Walter Paulus
The ability to simultaneously process and maintain multiple pieces of information is limited. Over the past 50 years, observational methods have provided a large amount of insight regarding the neural mechanisms that underpin the mental capacity that we refer to as "working memory." More than 20 years ago, a neural coding scheme was proposed for working memory. As a result of technological developments, we can now not only observe but can also influence brain rhythms in humans. Building on these novel developments, we have begun to externally control brain oscillations in order to extend the limits of working memory...
April 19, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29664908/a-new-model-of-wheezing-severity-in-young-children-using-the-validated-isaac-wheezing-module-a-latent-variable-approach-with-validation-in-independent-cohorts
#4
Steven M Brunwasser, Tebeb Gebretsadik, Diane R Gold, Kedir N Turi, Cosby A Stone, Soma Datta, James E Gern, Tina V Hartert
BACKGROUND: The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) consortium. However, there is no consensus model for operationalizing wheezing severity with this instrument in explanatory research studies. Severity is typically measured using coarsely-defined categorical variables, reducing power and potentially underestimating etiological associations...
2018: PloS One
https://www.readbyqxmd.com/read/29614133/digestive-enzymes-and-gut-morphometric-parameters-of-threespine-stickleback-gasterosteus-aculeatus-influence-of-body-size-and-temperature
#5
Younes Mohamed Ismail Hani, Adrien Marchand, Cyril Turies, Elodie Kerambrun, Olivier Palluel, Anne Bado-Nilles, Rémy Beaudouin, Jean-Marc Porcher, Alain Geffard, Odile Dedourge-Geffard
Determining digestive enzyme activity is of potential interest to obtain and understand valuable information about fish digestive physiology, since digestion is an elementary process of fish metabolism. We described for the first time (i) three digestive enzymes: amylase, trypsin and intestinal alkaline phosphatase (IAP), and (ii) three gut morphometric parameters: relative gut length (RGL), relative gut mass (RGM) and Zihler's index (ZI) in threespine stickleback (Gasterosteus aculeatus), and we studied the effect of temperature and body size on these parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29583048/pharmacokinetics-and-pharmacodynamics-after-oral-administration-of-tapentadol-hydrochloride-in-dogs
#6
James Howard, Turi K Aarnes, Jonathan Dyce, Phillip Lerche, Larry W Wulf, Johann F Coetzee, Jeffrey Lakritz
OBJECTIVE To evaluate pharmacokinetic and pharmacodynamic characteristics of 3 doses of tapentadol hydrochloride orally administered in dogs. ANIMALS 6 healthy adult mixed-breed dogs. PROCEDURES In a prospective, randomized crossover study, dogs were assigned to receive each of 3 doses of tapentadol (10, 20, and 30 mg/kg, PO); there was a 1-week washout period between subsequent administrations. Plasma concentrations and physiologic variables were measured for 24 hours. Samples were analyzed by use of high-performance liquid chromatography-tandem mass spectrometry...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29569997/patterns-of-physical-activity-and-screen-time-among-brazilian-children
#7
Lia Grego Muniz de Araújo, Bruna Camilo Turi, Bruna Locci, Camila Angélica Asahi Mesquita, Natália Bonicontro Fonsati, Henrique Luiz Monteiro
OBJECTIVE: To investigate the patterns of physical activity (PA) and screen time among children and adolescents attended by the Brazilian National Health System. METHODS: This cross-sectional study was conducted in the city of Bauru, São Paulo, Brazil. The sample was composed of 270 children and adolescents attending 5 basic health care units. PA and screen time were assessed through a questionnaire. Economic status, sex, and body composition variables were used as covariates...
March 23, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29569996/adults-engaged-in-sports-in-early-life-have-higher-bone-mass-than-their-inactive-peers
#8
Alessandra Madia Mantovani, Manoel Carlos Spiguel de Lima, Luis Alberto Gobbo, Enio Ricardo Vaz Ronque, Marcelo Romanzini, Bruna Camilo Turi-Lynch, Jamile Sanches Codogno, Rômulo Araújo Fernandes
PURPOSE: To analyze the relationship between engagement in sports in early life and bone variables among adults of both sexes. METHODS: The sample was composed of 225 men and women. Demographic data were collected, and dual-energy X-ray absorptiometry was used to assess bone mineral density, bone mineral content, and lean soft tissue. Sports participation in early life was assessed by an interview including childhood and adolescence. Consumption of tobacco and alcohol was also assessed by interview and the habitual physical activity level by a pedometer...
March 23, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29542712/sex-power-and-ancient-dna
#9
Turi King
No abstract text is available yet for this article.
March 15, 2018: Nature
https://www.readbyqxmd.com/read/29506652/pupillometry-reveals-perceptual-differences-that-are-tightly-linked-to-autistic-traits-in-typical-adults
#10
Marco Turi, David Charles Burr, Paola Binda
The pupil is primarily regulated by prevailing light levels but is also modulated by perceptual and attentional factors. We measured pupil-size in typical adult humans viewing a bistable-rotating cylinder, constructed so the luminance of the front surface changes with perceived direction of rotation. In some participants, pupil diameter oscillated in phase with the ambiguous perception, more dilated when the black surface was in front. Importantly, the magnitude of oscillation predicts autistic traits of participants, assessed by the Autism-Spectrum Quotient AQ...
March 6, 2018: ELife
https://www.readbyqxmd.com/read/29497727/high-efficiency-two-photon-uncaging-coupled-by-the-correction-of-spontaneous-hydrolysis
#11
Dénes Pálfi, Balázs Chiovini, Gergely Szalay, Attila Kaszás, Gergely F Turi, Gergely Katona, Péter Ábrányi-Balogh, Milán Szőri, Attila Potor, Orsolya Frigyesi, Csilla Lukácsné Haveland, Zoltán Szadai, Miklós Madarász, Anikó Vasanits-Zsigrai, Ibolya Molnár-Perl, Béla Viskolcz, Imre G Csizmadia, Zoltán Mucsi, Balázs Rózsa
Two-photon (TP) uncaging of neurotransmitter molecules is the method of choice to mimic and study the subtleties of neuronal communication either in the intact brain or in slice preparations. However, the currently available caged materials are just at the limit of their usability and have several drawbacks. The local and focal nature of their use may for example be jeopardized by a high spontaneous hydrolysis rate of the commercially available compounds with increased photochemical release rate. Here, using quantum chemical modelling we show the mechanisms of hydrolysis and two-photon activation, and synthesized more effective caged compounds...
March 14, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29493635/non-persistence-risk-and-health-care-resource-utilization-of-italian-patients-with-non-valvular-atrial-fibrillation
#12
Nazarena Cataldo, Valeria Pegoraro, Claudio Ripellino, Valentino Bertasi, Roberta Di Turi, Maurizio Pastorello, Marco Gambera
The aim of this study is to compare discontinuation risk and health care resource utilization between vitamin K antagonists (VKAs) and non-vitamin K antagonist oral anticoagulants (NOACs) in newly treated patients with non-valvular atrial fibrillation (NVAF). Based on administrative databases of five Italian Local Healthcare Units, all patients with a discharge diagnosis of NVAF between 2011 and 2014 were selected. Among them, the incident users of NOACs and VKAs in 2014 were followed-up to from the first prescription date to the occurrence of anyone of the following events: a 90-day gap in therapy, switch to a different molecule or add-on of a different molecule into the regimen, death of patient, end of follow-up (December 2015)...
February 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29475799/reprint-of-investigating-ensemble-perception-of-emotions-in-autistic-and-typical-children-and-adolescents
#13
Themelis Karaminis, Louise Neil, Catherine Manning, Marco Turi, Chiara Fiorentini, David Burr, Elizabeth Pellicano
Ensemble perception, the ability to assess automatically the summary of large amounts of information presented in visual scenes, is available early in typical development. This ability might be compromised in autistic children, who are thought to present limitations in maintaining summary statistics representations for the recent history of sensory input. Here we examined ensemble perception of facial emotional expressions in 35 autistic children, 30 age- and ability-matched typical children and 25 typical adults...
January 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29460407/clip-versus-suture-toe-to-toe-perspectives-on-and-beyond-the-evidence-base
#14
EDITORIAL
Zoltan G Turi
The evidence that StarClose is associated with a higher complication rate than Perclose is reasonable if less than robust. Closure results are affected by access technique. The rationale for using closure devices in small hole puncture is questionable both from a clinical as well as financial standpoint.
February 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29317186/perturbation-of-theta-gamma-coupling-at-the-temporal-lobe-hinders-verbal-declarative-memory
#15
Gabriel Amador de Lara, Ivan Alekseichuk, Zsolt Turi, Albert Lehr, Andrea Antal, Walter Paulus
BACKGROUND: Phase-amplitude cross-frequency coupling (PAC) is characterized by the modulation of the power of a fast brain oscillation (e.g., gamma) by the phase of a slow rhythm (e.g., theta). PAC in different sub- and neocortical regions is known to underlie effective neural communication and correlates with successful long-term memory formation. OBJECTIVE/HYPOTHESIS: The present work aims to extend earlier observational data, by probing the functional role of theta-gamma PAC in the left temporal cortex in humans during verbal long-term memory encoding...
December 25, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29314636/moving-beyond-seldinger-a-vascular-access-and-closure-smorgasbord-safe-zone-or-not
#16
EDITORIAL
Zoltan G Turi
This paper describes a quality improvement initiative featuring the adoption of multiple access and closure techniques to assess "real world" outcomes. Although the study does not provide a scientific evidence base, it does highlight the changing platforms being adopted. Radial, micropuncture, and image guided access will hopefully become near universal in the coming decade.
January 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29258400/evaluation-of-apoe-genotype-and-ability-to-perform-activities-of-daily-living-following-aneurysmal-subarachnoid-hemorrhage
#17
Lacey Wright Heinsberg, Eleanor Turi, Dianxu Ren, Elizabeth Crago, Sheila Alexander, Ansley Grimes Stanfill, Yvette Perry Conley
Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the central nervous system and to moderate the inflammatory response, making functional variations in this gene likely candidate biomarkers to predict outcomes following aSAH. In the present work, we examined the relationship between APOE genotype and the ability to perform activities of daily living as measured by the Barthel Index (BI) score at 3 months ( n = 298) and 12 months ( n = 288) following aSAH...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29211715/alcohol-abuse-drug-disulfiram-targets-cancer-via-p97-segregase-adaptor-npl4
#18
Zdenek Skrott, Martin Mistrik, Klaus Kaae Andersen, Søren Friis, Dusana Majera, Jan Gursky, Tomas Ozdian, Jirina Bartkova, Zsofia Turi, Pavel Moudry, Marianne Kraus, Martina Michalova, Jana Vaclavkova, Petr Dzubak, Ivo Vrobel, Pavla Pouckova, Jindrich Sedlacek, Andrea Miklovicova, Anne Kutt, Jing Li, Jana Mattova, Christoph Driessen, Q Ping Dou, Jørgen Olsen, Marian Hajduch, Boris Cvek, Raymond J Deshaies, Jiri Bartek
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also known by the trade name Antabuse), an old alcohol-aversion drug that has been shown to be effective against diverse cancer types in preclinical studies. Our nationwide epidemiological study reveals that patients who continuously used disulfiram have a lower risk of death from cancer compared to those who stopped using the drug at their diagnosis...
December 14, 2017: Nature
https://www.readbyqxmd.com/read/29143558/perturbation-of-rna-polymerase-i-transcription-machinery-by-ablation-of-heatr1-triggers-the-rpl5-rpl11-mdm2-p53-ribosome-biogenesis-stress-checkpoint-pathway-in-human-cells
#19
Zsofia Turi, Marketa Senkyrikova, Martin Mistrik, Jiri Bartek, Pavel Moudry
Ribosome biogenesis is an energy consuming process which takes place mainly in the nucleolus. By producing ribosomes to fuel protein synthesis, it is tightly connected with cell growth and cell cycle control. Perturbation of ribosome biogenesis leads to the activation of p53 tumor suppressor protein promoting processes like cell cycle arrest, apoptosis or senescence. This ribosome biogenesis stress pathway activates p53 through sequestration of MDM2 by a subset of ribosomal proteins (RPs), thereby stabilizing p53...
2018: Cell Cycle
https://www.readbyqxmd.com/read/29122431/nonsurgical-strategies-to-reduce-mortality-in-patients-undergoing-cardiac-surgery-an-updated-consensus-process
#20
Giovanni Landoni, Vladimir Lomivorotov, Simona Silvetti, Caetano Nigro Neto, Antonio Pisano, Gabriele Alvaro, Ludmilla Abrahao Hajjar, Gianluca Paternoster, Hynek Riha, Fabrizio Monaco, Andrea Szekely, Rosalba Lembo, Nesrin A Aslan, Giovanni Affronti, Valery Likhvantsev, Cristiano Amarelli, Evgeny Fominskiy, Martina Baiardo Redaelli, Alessandro Putzu, Massimo Baiocchi, Jun Ma, Giuseppe Bono, Valentina Camarda, Remo Daniel Covello, Nora Di Tomasso, Miriam Labonia, Carlo Leggieri, Rosetta Lobreglio, Giacomo Monti, Paolo Mura, Anna Mara Scandroglio, Daniela Pasero, Stefano Turi, Agostino Roasio, Carmine D Votta, Emanuela Saporito, Claudio Riefolo, Chiara Sartini, Luca Brazzi, Rinaldo Bellomo, Alberto Zangrillo
OBJECTIVE: A careful choice of perioperative care strategies is pivotal to improve survival in cardiac surgery. However, there is no general agreement or particular attention to which nonsurgical interventions can reduce mortality in this setting. The authors sought to address this issue with a consensus-based approach. DESIGN: A systematic review of the literature followed by a consensus-based voting process. SETTING: A web-based international consensus conference...
February 2018: Journal of Cardiothoracic and Vascular Anesthesia
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