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https://www.readbyqxmd.com/read/28430909/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#1
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28427582/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#2
REVIEW
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28424379/-risk-factors-of-eating-disorders-in-the-narratives-of-fashion-models
#3
Nikolett Bogár, Ferenc Túry
INTRODUCTION: The risk of eating disorders is high in populations who are exposed to slimness ideal, so among fashion models. The present qualitative study evaluates the risk factors of eating disorders in a group of fashion models with semistructured interview. Moreover, the aim of the study was to examine the impact of professional requirements on the health of models. METHODS: The study group was internationally heterogeneous. The models were involved by personal professional relationship...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/28392704/predictive-parameters-in-hypofractionated-whole-breast-3d-conformal-radiotherapy-according-to-the-ontario-canadian-trial
#4
Grazia Lazzari, Angela Terlizzi, Giuseppina Della Vittoria Scarpati, Francesco Perri, Vincenzo De Chiara, Barbara Turi, Giovanni Silvano
AIM: To evaluate the possible role of dosimetric parameters according Normal Tissue Complication Probability (NTCP) model as predictive of late toxicity and cosmesis in hypofractionated whole-breast three-dimensional conformal radiotherapy. PATIENTS AND METHODS: A retrospective analysis on 215 consecutive early breast cancer patients treated with breast conserving surgery and adjuvant hypofractionated whole-breast radiotherapy (according the Ontario Canadian trial), with a 6 years median follow-up was conducted...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28380203/determinants-of-outpatient-expenditure-within-primary-care-in-the-brazilian-national-health-system
#5
Bruna Camilo Turi, Jamile Sanches Codogno, Flávia Mori Sarti, Nana Kwame Anokye, Rômulo Araújo Fernandes, Henrique Luiz Monteiro
CONTEXT AND OBJECTIVE: One of the big challenges facing governments worldwide is the financing of healthcare systems. Thus, it is necessary to understand the factors and key components associated with healthcare expenditure. The aim here was to identify demographic, socioeconomic, lifestyle and clinical factors associated with direct healthcare expenditure within primary care, among adults attended through the Brazilian National Health System in the city of Bauru. DESIGN AND SETTING: Cross-sectional study conducted in five primary care units in Bauru (SP), Brazil...
April 3, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28352948/visual-information-from-observing-grasping-movement-in-allocentric-and-egocentric-perspectives-development-in-typical-children
#6
Francesca Tinelli, Giovanni Cioni, Giulio Sandini, Marco Turi, Maria Concetta Morrone
Development of the motor system lags behind that of the visual system and might delay some visual properties more closely linked to action. We measured the developmental trajectory of the discrimination of object size from observation of the biological motion of a grasping action in egocentric and allocentric viewpoints (observing action of others or self), in children and adolescents from 5 to 18 years of age. Children of 5-7 years of age performed the task at chance, indicating a delayed ability to understand the goal of the action...
March 28, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28330913/reconciling-evidence-from-ancient-and-contemporary-genomes-a-major-source-for-the-european-neolithic-within-mediterranean-europe
#7
Joana B Pereira, Marta D Costa, Daniel Vieira, Maria Pala, Lisa Bamford, Nourdin Harich, Lotfi Cherni, Farida Alshamali, Jiři Hatina, Sergey Rychkov, Gheorghe Stefanescu, Turi King, Antonio Torroni, Pedro Soares, Luísa Pereira, Martin B Richards
Important gaps remain in our understanding of the spread of farming into Europe, due partly to apparent contradictions between studies of contemporary genetic variation and ancient DNA. It seems clear that farming was introduced into central, northern, and eastern Europe from the south by pioneer colonization. It is often argued that these dispersals originated in the Near East, where the potential source genetic pool resembles that of the early European farmers, but clear ancient DNA evidence from Mediterranean Europe is lacking, and there are suggestions that Mediterranean Europe may have resembled the Near East more than the rest of Europe in the Mesolithic...
March 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28329411/tv-viewing-time-is-associated-with-increased-all-cause-mortality-in-brazilian-adults-independent-of-physical-activity
#8
Bruna Camilo Turi, Henrique Luiz Monteiro, Ítalo Ribeiro Lemes, Jamile Sanches Codogno, Kyle Robinson Lynch, Camila Angélica Asahi Mesquita, Rômulo Araújo Fernandes
The purpose of this study was to investigate the association between television (TV) viewing and all-cause mortality among Brazilian adults after six years of follow-up. This longitudinal study started in 2010 in the city of Bauru, SP, Brazil, and involved 970 adults aged ≥ 50 years. Mortality was reported by relatives and confirmed in medical records of the Brazilian National Health System. Physical activity (PA) and TV viewing were assessed by the Baecke questionnaire. Health status, sociodemographic and behavioural covariates were considered as potential confounders...
March 22, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28301964/not-good-enough-further-comments-to-the-wording-meaning-and-the-conceptualization-of-internet-gaming-disorder
#9
Elfrid Krossbakken, Ståle Pallesen, Helge Molde, Rune Aune Mentzoni, Turi Reiten Finserås
In their commentary, Kuss, Griffiths, and Pontes (2016) criticize the use of the term "Internet" in the recently proposed diagnosis for Internet Gaming Disorder (IGD) and its use as one of the included diagnostic criteria. We agree with the exclusion of the term "Internet" in the diagnosis, but have some considerations to the comments regarding the nine criteria for IGD. Specifically, we discuss the meaning, the wording, and the importance of the criteria, as well as the importance of distress or functional impairment in the proposed diagnosis...
March 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28296003/a-multicenter-randomized-trial-comparing-the-effectiveness-and-safety-of-a-novel-vascular-closure-device-to-manual-compression-in-anticoagulated-patients-undergoing-percutaneous-transfemoral-procedures-the-celt-acd-trial
#10
Shing Chiu Wong, Michael Laule, Zoltan Turi, Wasiem Sanad, James Crowley, Hubertus Degen, Kathleen Bennett, Jim E Coleman, Geoffrey Bergman
OBJECTIVES: This study compared the performance of Celt ACD(®) , a novel stainless steel based vascular closure device versus manual compression (MC) for femoral arteriotomy site hemostasis in patients undergoing percutaneous coronary procedures. BACKGROUND: Optimal access site management after percutaneous transfemoral procedures remains controversial. METHODS: Patients enrolled in this multicenter, randomized open label trial underwent 6-F diagnostic or interventional procedures and were assigned 2:1 to Celt ACD(®) versus MC...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28278129/predicting-risk-of-type-2-diabetes-by-using-data-on-easy-to-measure-risk-factors
#11
Kedir N Turi, David M Buchner, Diana S Grigsby-Toussaint
INTRODUCTION: Statistical models for assessing risk of type 2 diabetes are usually additive with linear terms that use non-nationally representative data. The objective of this study was to use nationally representative data on diabetes risk factors and spline regression models to determine the ability of models with nonlinear and interaction terms to assess the risk of type 2 diabetes. METHODS: We used 4 waves of data (2005-2006 to 2011-2012) on adults aged 20 or older from the National Health and Nutrition Examination Survey (n = 5,471) and multivariate adaptive regression splines (MARS) to build risk models in 2015...
March 9, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28267102/association-between-costs-related-to-productivity-loss-and-modified-risk-factors-among-users-of-the-brazilian-national-health-system
#12
Monique Yndawe Castanho Araujo, Flávia Mori Sarti, Rômulo Araújo Fernandes, Henrique Luiz Monteiro, Bruna Camilo Turi, Nana Anokye, Jamile Sanches Codogno
OBJECTIVES: The aim of this study was to investigate the associations between costs related to productivity losses and its risk factors among users of the Brazilian National Health System. METHODS: The public cost associated with productivity losses of 342 adults has been estimated, taking into account a period of 18 months. Costs related to productivity loss were estimate using data provided by the Brazilian National Health System (disability retirements) and absenteeism...
March 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28253046/effect-of-moderate-intensity-exercise-on-inflammatory-markers-among-postmenopausal-women
#13
Eduardo Federighi Baisi Chagas, Mariana Rotta Bonfim, Bruna Camilo Turi, Nair Cristina Margarida Brondino, Henrique Luiz Monteiro
BACKGROUND: Declines in ovarian function in postmenopausal women may contribute to increase inflammatory cytokines, which can lead to chronic diseases. However, studies have shown that exercise interventions are important to manage inflammatory conditions. Thus, the objective of this study was to analyze the effect of exercise intervention on inflammatory markers among obese and postmenopausal women. METHODS: 70 women composed the sample (Exercise group [EG; n=35] and non-exercise group [nEG; n=35])...
March 2, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28240955/pharmacokinetics-and-pharmacodynamics-of-buprenorphine-and-sustained-release-buprenorphine-after-administration-to-adult-alpacas
#14
S Bryce Dooley, Turi K Aarnes, Jeffrey Lakritz, Phillip Lerche, Richard M Bednarski, John A E Hubbell
OBJECTIVE To determine pharmacokinetics and pharmacodynamics of buprenorphine after IV and SC administration and of sustained-release (SR) buprenorphine after SC administration to adult alpacas. ANIMALS 6 alpacas. PROCEDURES Buprenorphine (0.02 mg/kg, IV and SC) and SR buprenorphine (0.12 mg/kg, SC) were administered to each alpaca, with a 14-day washout period between administrations. Twenty-one venous blood samples were collected over 96 hours and used to determine plasma concentrations of buprenorphine. Pharmacokinetic parameters were calculated by use of noncompartmental analysis...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28230817/common%C3%A2-chemical%C3%A2-inductors%C3%A2-of%C3%A2-replication%C3%A2-stress-%C3%A2-focus%C3%A2-on%C3%A2-cell-based%C3%A2-studies
#15
REVIEW
Eva Vesela, Katarina Chroma, Zsofia Turi, Martin Mistrik
DNA replication is a highly demanding process regarding the energy and material supply and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or stalling of DNA synthesis and/or replication forks is referred to as replication stress (RS). Owing to the complexity and requirements of replication, a plethora of factors may interfere and challenge the genome stability, cell survival or affect the whole organism. This review outlines chemical compounds that are known inducers of RS and commonly used in laboratory research...
February 21, 2017: Biomolecules
https://www.readbyqxmd.com/read/28216687/effect-of-pre-warming-on-perioperative-hypothermia-and-anesthetic-recovery-in-small-breed-dogs-undergoing-ovariohysterectomy
#16
Turi K Aarnes, Richard M Bednarski, Phillip Lerche, John A E Hubbell
This study compared perianesthetic body temperatures and times to recovery from general anesthesia in small dogs that were either warmed for 20 minutes prior to anesthesia or not warmed. Twenty-eight client-owned dogs that were presented for ovariohysterectomy were included in the study. Small (<10 kg body weight) dogs with normal circulatory status were randomly assigned to receive pre-warming for 20 minutes or no treatment. Body temperature was measured during the procedure using a calibrated rectal probe...
February 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28160619/ensemble-perception-of-emotions-in-autistic-and-typical-children-and-adolescents
#17
Themelis Karaminis, Louise Neil, Catherine Manning, Marco Turi, Chiara Fiorentini, David Burr, Elizabeth Pellicano
Ensemble perception, the ability to assess automatically the summary of large amounts of information presented in visual scenes, is available early in typical development. This ability might be compromised in autistic children, who are thought to present limitations in maintaining summary statistics representations for the recent history of sensory input. Here we examined ensemble perception of facial emotional expressions in 35 autistic children, 30 age- and ability-matched typical children and 25 typical adults...
January 16, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28132825/in%C3%A2-vivo-imaging-of-dentate-gyrus-mossy-cells-in-behaving-mice
#18
Nathan B Danielson, Gergely F Turi, Max Ladow, Spyridon Chavlis, Panagiotis C Petrantonakis, Panayiota Poirazi, Attila Losonczy
Mossy cells in the hilus of the dentate gyrus constitute a major excitatory principal cell type in the mammalian hippocampus; however, it remains unknown how these cells behave in vivo. Here, we have used two-photon Ca(2+) imaging to monitor the activity of mossy cells in awake, behaving mice. We find that mossy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning during head-fixed spatial navigation, and undergo robust remapping of their spatial representations in response to contextual manipulation...
February 8, 2017: Neuron
https://www.readbyqxmd.com/read/28132542/-atypical-complaint-in-myocardial-ischaemia-belching
#19
Nóra Turi-Kováts, Hrisula Arabadzisz, András Zsoldos, János Tomcsányi
While educating non-medical personnel on acute coronary syndrome we often emphasize the importance of early recognition and urgent transfer to acute cardiac center of patients with acute myocardial infarction. Aside from typical symptoms of chest tightness and pain radiating to shoulder, arm and jaw, angina often presents with atypical, non-cardiac complaints. These symptoms, often suggesting gastrointestinal problems, can sometimes mislead even the most experienced physicians. We would like to present the case of an 83-year-old woman with several decades long history of ischaemic heart disease, who recently developed a new anginal symptom: lound, uncontrollable belching...
February 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28112207/placebo-intervention-enhances-reward-learning-in-healthy-individuals
#20
Zsolt Turi, Matthias Mittner, Walter Paulus, Andrea Antal
According to the placebo-reward hypothesis, placebo is a reward-anticipation process that increases midbrain dopamine (DA) levels. Reward-based learning processes, such as reinforcement learning, involves a large part of the DA-ergic network that is also activated by the placebo intervention. Given the neurochemical overlap between placebo and reward learning, we investigated whether verbal instructions in conjunction with a placebo intervention are capable of enhancing reward learning in healthy individuals by using a monetary reward-based reinforcement-learning task...
January 23, 2017: Scientific Reports
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