keyword
https://read.qxmd.com/read/38533732/schwannoma-of-the-phrenic-nerve-a-case-report
#21
JOURNAL ARTICLE
Josef Chudacek, Tomas Bohanes, Marek Szkorupa, Martin Stasek, Jan Hanuliak, Daniela Skanderova, Dusan Klos
BACKGROUND: Neurogenic tumors are the third most common tumors occurring within the mediastinum. Predominantly completely asymptomatic, they are most often found in the posterior mediastinum, although they may also be located, albeit rarely, in the middle mediastinum. Thus, in the cases of tumors localized in the middle mediastinum, schwannomas of the phrenic nerve must always be considered. CASE REPORT: In this case, a male patient presented with a tumor of the middle mediastinum...
March 27, 2024: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/38533646/novel-bispecific-nanobody-mitigates-experimental-intestinal-inflammation-in-mice-by-targeting-tnf-%C3%AE-and-il-23p19-bioactivities
#22
JOURNAL ARTICLE
Jiewen Wang, Guangbo Kang, Huiying Lu, Ario de Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, Yuli Wang, Miao Zhang, Ping Wang, Yuanhang Feng, Zhanju Liu, Xiaocang Cao, He Huang
BACKGROUND: Inflammatory bowel diseases (IBDs) pose significant challenges in terms of treatment non-response, necessitating the development of novel therapeutic approaches. Although biological medicines that target TNF-α (tumour necrosis factor-α) have shown clinical success in some IBD patients, a substantial proportion still fails to respond. METHODS: We designed bispecific nanobodies (BsNbs) with the ability to simultaneously target human macrophage-expressed membrane TNF-α (hmTNF-α) and IL-23...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38533234/titanium-mesh-cranioplasty-for-cosmetically-disfiguring-cranio-facial-tumours-in-a-resource-limited-setting
#23
JOURNAL ARTICLE
C O Anele, S A Balogun, C O Ezeaku, T O Ajekwu, H E Omon, G O Ejembi, E O Komolafe
BACKGROUND: The aesthetic reconstruction of disfiguring cranio-facial defects after tumour excision can be quite challenging to the neurosurgeon with limited resources. The choice of cranioplasty implant, intraoperative technicalities and the patients' postoperative appearance are critical considerations in management. There are a number of synthetic materials available for cranioplasty, however, the customised implants are not readily available in our practice setup. They are also mostly constructed and contoured after the bony defect has been created or require sophisticated software construction pre-operatively...
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38533005/prognostic-correlation-between-specialized-capillary-endothelial-cells-and-lung-adenocarcinoma
#24
JOURNAL ARTICLE
Rongchang Zhao, Yan Ding, Rongbo Han, Rongjie Ding, Jun Liu, Chunrong Zhu, Dan Ding, Minhui Bao
BACKGROUND: In-depth analysis of the functional changes occurring in endothelial cells (ECs) involved in capillary formation can help to elucidate the mechanism of tumour vascular growth. METHODS: Appropriate datasets were retrieved from the GEO database to obtain single-cell data on LUAD samples and adjacent normal tissue samples. ECs were selected by an automatic annotation program in R and further subdivided based on reported EC marker genes. Functional changes in different types of capillary ECs were then visualized, and the concrete expression was classified by genetic data in the TCGA...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532697/identifying-the-best-candidate-for-primary-tumor-resection-in-patients-with-advanced-osteosarcoma
#25
JOURNAL ARTICLE
Zhengjiang Li, Xingyao Yang, Shuxing Xing
OBJECTIVES: Not all patients with stage III and IV osteosarcoma who undergo surgery to remove the primary tumor will benefit from surgery; therefore, we developed a nomogram model to test the hypothesis that only a subset of patients will benefit from surgery. METHODS: 412 patients were screened from the Surveillance, Epidemiology and End Results (SEER) database. Subsequently, 1:1 propensity score matching (PSM) was used to screen and balance confounders. We first made the hypothesis that patients who underwent the procedure would benefit more...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38532609/proton-pump-inhibitors-enhance-macropinocytosis-mediated-extracellular-vesicle-endocytosis-by-inducing-membrane-v-atpase-assembly
#26
JOURNAL ARTICLE
Xinliang Lu, Zhengbo Song, Jiayue Hao, Xianghui Kong, Weiyi Yuan, Yingying Shen, Chengyan Zhang, Jie Yang, Pengfei Yu, Yun Qian, Gensheng Zhang, Huajun Feng, Jianli Wang, Zhenzhai Cai, Zhijian Cai
Besides participating in diverse pathological and physiological processes, extracellular vesicles (EVs) are also excellent drug-delivery vehicles. However, clinical drugs modulating EV levels are still lacking. Here, we show that proton pump inhibitors (PPIs) reduce EVs by enhancing macropinocytosis-mediated EV uptake. PPIs accelerate intestinal cell endocytosis of autocrine immunosuppressive EVs through macropinocytosis, thereby aggravating inflammatory bowel disease. PPI-induced macropinocytosis facilitates the clearance of immunosuppressive EVs from tumour cells, improving antitumor immunity...
April 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38532566/analyses-of-tertiary-lymphoid-structures-observed-in-cases-of-merkel-cell-carcinoma-showing-spontaneous-regression
#27
JOURNAL ARTICLE
Motoki Nakamura, Maki Yoshimitsu, Tetsuya Magara, Shinji Kano, Hiroshi Kato, Akimichi Morita
Merkel cell carcinoma (MCC) is a high-grade skin cancer, but spontaneous regression is observed at a markedly higher frequency than in other carcinomas. Although spontaneous regression is a phenomenon that greatly impacts treatment planning, we still cannot predict it. We previously reported on the prognostic impact of the presence or absence of tertiary lymphoid structures (TLS) and of Merkel cell polyomavirus (MCPyV) infection. To learn more about the spontaneous regression of MCC, detailed analyses were performed focusing on spontaneous regression cases...
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38532497/robotic-portal-resection-for-mediastinal-tumours-a-prospective-observational-study
#28
JOURNAL ARTICLE
Wei Gan, Mu-Zi Yang, Zi-Hui Tan, Chu-Long Xie, Tian-Yu Sun, Hao-Xian Yang
BACKGROUND: To demonstrate the effectiveness and feasibility of robotic portal resection (RPR) for mediastinal tumour using a prospectively collected database. METHODS: Data from 73 consecutive patients with mediastinal tumours who underwent RPRs were prospectively collected from August 2018 to April 2023. All patients underwent chest and abdominal enhanced computed tomography (CT) and preoperative multidisciplinary team (MDT) discussion. The patients were stratified into two groups based on tumour size: Group A (tumour size < 4 cm) and Group B (tumour size ≥ 4 cm)...
March 26, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38532169/resection-status-and-margin-control-in-intraoperative-frozen-sectioning-analysis-of-oral-squamous-cell-carcinoma
#29
JOURNAL ARTICLE
Felix Neumann, Xenia Straub, Friedrich Mrosk, Kerstin Rubarth, Johanna Wolfsberg, Iris Piwonski, Christian Doll, Jan Voss, Max Heiland, Kilian Kreutzer, Steffen Koerdt
PURPOSE: Intraoperative frozen section analysis (IFSA) is a well-established procedure for determining the intraoperative soft tissue resection status in patients with oral squamous cell carcinoma (OSCC). Margin status is a major predictor of the patient´s outcome, histologically free margins of ≥ 5 mm are demanded. This study evaluates the accuracy of IFSA, the impact of margin status and the impact of intraoperative margin revision on disease-free survival (DFS) and overall survival (OS)...
March 27, 2024: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38532155/customised-pre-operative-cranioplasty-to-achieve-maximal-surgical-resection-of-tumours-with-osseous-involvement-a-case-series
#30
JOURNAL ARTICLE
Swati Jain, Adel Helmy, Thomas Santarius, Nicola Owen, Kirsty Grieve, Peter Hutchinson, Ivan Timofeev
PURPOSE: Surgical resection with bony margins would be the treatment of choice for tumours with osseous involvement such as meningiomas and metastasis. By developing and designing pre-operative customised 3D modelled implants, the patient can undergo resection of meningioma and repair of bone defect in the same operation. We present a generalisable method for designing pre-operative cranioplasty in patients to repair the bone defect after the resection of tumours. MATERIALS AND METHODS: We included six patients who presented with a tumour that was associated with overlying bone involvement...
March 27, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38531998/is-there-an-advantage-to-delayed-molar-implant-placement-in-those-with-chronic-apical-periodontitis
#31
JOURNAL ARTICLE
Rabab Ahmad
DESIGN: This paper is a single-centre, double-blinded, prospective randomised control trial, comparing immediate vs delayed implant placement clinically and radiographically in patients with chronic periodontitis, specifically assessing the molar region. Seventy-four patients were recruited to the study over a one-year period, all of whom returned for follow up throughout the study. STUDY SELECTION: The study adhered to the principles outlined in the Declaration of Helsinki and obtained ethical approval from the affiliated University Hospital of Qingdao...
March 26, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38531846/usp3-promotes-osteosarcoma-progression-via-deubiquitinating-epha2-and-activating-the-pi3k-akt-signaling-pathway
#32
JOURNAL ARTICLE
Anan Li, Shijiang Wang, Jiangbo Nie, Shining Xiao, Xinsheng Xie, Yu Zhang, Weilai Tong, Geliang Yao, Ning Liu, Fan Dan, Zhiguo Shu, Jiaming Liu, Zhili Liu, Feng Yang
Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly understood. The aim of this study was to explore the biological function of USP3 in OS and the underlying molecular mechanism. We found that OS had higher USP3 expression compared with that of normal bone tissue, and high expression of USP3 was associated with poor prognosis in patients with OS. Overexpression of USP3 significantly increased OS cell proliferation, migration, and invasion...
March 26, 2024: Cell Death & Disease
https://read.qxmd.com/read/38531626/extent-of-investigation-and-management-of-cases-of-unexplained-mismatch-repair-deficiency-u-dmmr-a-uk-cancer-genetics-group-consensus
#33
JOURNAL ARTICLE
Terri Patricia McVeigh, Kevin J Monahan, Joseph Christopher, Nick West, Malcolm Scott, Jennie Murray, Helen Hanson
BACKGROUND: Mismatch repair deficiency (dMMR) is a characteristic feature of cancers linked to Lynch syndrome. However, in most cases, it results from sporadic somatic events rather than hereditary factors. The term 'Lynch-like syndrome' (LLS) has been used to guide colorectal cancer surveillance for relatives of individuals with a dMMR tumour when somatic and germline genomic testing is uninformative. As the assessment of mismatch repair through immunohistochemistry and/or microsatellite instability is increasingly applied across various tumour types for treatment planning, dMMR is increasingly detected in tumours where suspicion of hereditary aetiology is low...
March 26, 2024: Journal of Medical Genetics
https://read.qxmd.com/read/38531576/efficacy-and-safety-of-natural-killer-cells-injection-combined-with-xelox-chemotherapy-in-postoperative-patients-with-stage-iii-colorectal-cancer-in-china-a-prospective-randomised-controlled-clinical-trial-study-protocol
#34
JOURNAL ARTICLE
Shan Geng, Xingrui Yu, Shaohong Yu
BACKGROUND: Colorectal cancer (CRC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in China. However, resistance to multiple chemotherapeutics after surgery leads to failure of the main therapy to CRC. Natural killer (NK) cells are innate cytotoxic lymphocytes that exhibit strong cytotoxic activity against tumour cells. NK cell-based therapy, either alone or in combination with chemotherapy, has achieved favourable results and holds promise for addressing recurrence and metastasis in CRC patients after surgery...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531570/precise-infliximab-exposure-and-pharmacodynamic-control-to-achieve-deep-remission-in-paediatric-crohn-s-disease-remodel-cd-study-protocol-for-a-multicentre-open-label-pragmatic-clinical-trial-in-the-usa
#35
JOURNAL ARTICLE
Phillip Paul Minar, Ruben J Colman, Nanhua Zhang, Tomoyuki Mizuno, Alexander A Vinks
INTRODUCTION: The only biologic therapy currently approved to treat moderate to severe Crohn's disease in children (<18 years old) are those that antagonise tumour necrosis factor-alpha (anti-TNF). Therefore, it is critically important to develop novel strategies that maximise treatment effectiveness in this population. There is growing evidence that rates of sustained corticosteroid-free clinical remission, endoscopic healing and drug durability considerably improve when patients receive early anti-TNF dose optimisations guided by reactive or proactive therapeutic drug monitoring and pharmacodynamic monitoring...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531555/spontaneous-eruptive-disseminated-lobular-capillary-haemangioma
#36
JOURNAL ARTICLE
Varshini Neelathalli Ramachandraiah, Murali Narasimhan, Rashmi Rithusha Venugopal, Venugopal Vakati
Lobular capillary haemangioma (LCH), previously known as pyogenic granuloma, is a benign vascular tumour of the skin or mucosa. We report a patient with spontaneous eruption of LCH, a rare occurrence, which resolved probably due to reverse koebnerisation.
March 25, 2024: BMJ Case Reports
https://read.qxmd.com/read/38531534/comprehensive-assessment-of-risk-factors-and-pathogenic-characteristics-of-wound-infections-following-thoracoscopic-radical-resection-for-lung-cancer
#37
JOURNAL ARTICLE
Jian Xu, Jianhua Zhu
Lung cancer remains a leading cause of cancer-related mortality, with surgical resection as a primary treatment modality. However, postoperative wound infections (PWIs) pose significant risks following thoracoscopic radical resection. This study aims to identify the risk factors and pathogenetic characteristics associated with PWIs in lung cancer surgery. A comprehensive retrospective study was conducted from August 2021 to June 2023 at our institution. The study included 30 patients who developed PWIs and 60 controls who did not, following thoracoscopic radical resection for lung cancer...
April 2024: International Wound Journal
https://read.qxmd.com/read/38531329/treatment-and-long-term-safety-outcomes-of-peptide-receptor-radionuclide-therapy-for-metastatic-neuroendocrine-tumours-an-asian-experience
#38
JOURNAL ARTICLE
Wei Ying Tham, Hian Liang Huang, David Wai Meng Tai, John C Allen, Jacqueline S G Hwang, Lih Ming Loh, Brian K P Goh, Simon Y K Ong, Peng Chin Kek, Damien M Y Tan, David C E Ng, Kelvin S H Loke
Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population...
March 26, 2024: Neuroendocrinology
https://read.qxmd.com/read/38531232/staging-laparoscopy-in-gastric-cancer-patients-from-a-dutch-nationwide-delphi-consensus-towards-a-standardized-protocol
#39
JOURNAL ARTICLE
Karen van der Sluis, Niels A D Guchelaar, Lianne Triemstra, Ron H J Mathijssen, Jelle P Ruurda, Bas P L Wijnhoven, Johanna W van Sandick
BACKGROUND: Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. METHODS: All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The study involved an initial questionnaire with a 3-point Likert scale, an online consensus meeting, and a second questionnaire using a 2-point Likert scale (agree/disagree)...
March 19, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38530585/low-cubilin-myeloperoxidase-ratio-as-a-promising-biomarker-for-prognosis-of-high-grade-t1-bladder-cancer
#40
JOURNAL ARTICLE
Mariana Silva Medeiros, Luís André Botelho de Carvalho, Marta Alves, Ana Papoila, Hugo Miguel Baptista Carreira Dos Santos, José-Luis Capelo-Martínez, Luís Manuel Viegas de Campos Pinheiro
PURPOSE: T1 bladder cancer is known for its high progression and recurrence rates. Identifying aggressive tumours at the non-muscle-invasive stage is crucial to allow early interventions and subsequently increase patient survival. This study aimed to investigate the potential of the cubilin/myeloperoxidase (CUBN/MPO) ratio as a high-grade T1 bladder cancer biomarker. METHODS: Urine samples were collected from 30 patients who underwent transurethral resection of the tumour with high-grade T1 bladder cancer (June 2015 to December 2019) before surgery...
March 26, 2024: International Urology and Nephrology
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