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https://www.readbyqxmd.com/read/29323550/assessing-the-effect-of-weight-based-protocol-modifications-to-lower-dose-for-ct-guided-hepatic-and-renal-tumor-radiofrequency-ablations
#1
Supriya Gupta, Ronald S Arellano, Debra A Gervais, Dushyant V Sahani
OBJECTIVE: This study assessed radiation dose after CT-guided percutaneous radiofrequency ablations (RFAs) of hepatic and renal tumors and the effect of weight-based CT protocol modification for lowering overall dose in these procedures. MATERIALS AND METHODS: CT-guided RFA for renal and hepatic ablations performed from January 1, 2009, through December 31, 2009, were retrospectively reviewed (90 men and 48 women; age, 42-81 years). The radiation dose was recorded during each of the following steps: planning, performing, and postprocedure...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29315714/brain-abnormalities-in-cognition-anxiety-and-depression-regulatory-regions-in-adolescents-with-single-ventricle-heart-disease
#2
Nancy A Pike, Bhaswati Roy, Ritika Gupta, Sadhana Singh, Mary A Woo, Nancy J Halnon, Alan B Lewis, Rajesh Kumar
BACKGROUND: Single ventricle heart disease (SVHD) adolescents show cognitive impairments and anxiety and depressive symptoms, indicating the possibility of brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites in SVHD remains unclear. We examined brain tissue changes in SVHD compared to controls using T2-relaxometry procedures, which measure free water content and show tissue injury. METHODS: Proton-density and T2-weighted images, using a 3...
January 6, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29305791/utility-and-limitations-of-glycated-hemoglobin-hba1c-in-patients-with-liver-cirrhosis-as-compared-with-oral-glucose-tolerance-test-for-diagnosis-of-diabetes
#3
Tejasav Sehrawat, Anuraag Jindal, Paaras Kohli, Amit Thour, Jasbinder Kaur, Atul Sachdev, Yashdeep Gupta
INTRODUCTION: To study the utility of glycated hemoglobin (HbA1c) in the diagnosis of diabetes in patients with cirrhosis as compared to the gold standard oral glucose tolerance test (OGTT) and to see the effect of anemia and severity of cirrhosis on its performance. METHODS: Individuals (n = 100) with an established diagnosis of liver cirrhosis were recruited. The OGTT was performed as described by the World Health Organization (WHO). The severity of cirrhosis was calculated using the Child-Turcotte-Pugh (CTP) score...
January 5, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29258541/intravenous-iron-vs-blood-for-acute-post-partum-anaemia-iibappa-a-prospective-randomised-trial
#4
Seng Chua, Sarika Gupta, Jennifer Curnow, Beata Gidaszewski, Marjan Khajehei, Hayley Diplock
BACKGROUND: Acute post-partum anaemia can be associated with significant morbidity including a predisposition for postnatal depression. Lack of clear practice guidelines means a number of women are treated with multiple blood transfusions. Intravenous iron has the potential to limit the need for multiple blood transfusions but its role in the post-partum setting is unclear. METHODS/DESIGN: IIBAPPA is a multi-centre randomised non-inferiority trial. Women with a primary post-partum haemorrhage (PPH) >1000 mL and resultant haemoglobin (Hb) 5...
December 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29227424/effect-of-antiretroviral-therapy-on-growth-parameters-of-children-with-hiv-infection
#5
Anju Seth, Rajeev Kumar Malhotra, Rohini Gupta, Jagdish Chandra, Praveen Kumar, Sarita Singh, Garima Sharma
BACKGROUND: Children living with HIV (CLHIV) commonly experience growth failure. We report growth parameters in CLHIV at baseline and during 3 years of antiretroviral therapy (ART). METHODS: Records of CLHIV who had completed at least 3 years on ART were reviewed after excluding subjects who died, were lost to follow-up or developed treatment failure to assess impact of sustained administration of ART. Height-for-age (HFA) and body mass index for age (BFA) Z scores were calculated, and proportion of CLHIV with wasting and stunting estimated at baseline, 6, 12, 24 and 36 months after starting ART using the linear mixed model...
January 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29218903/coalitional-game-theory-as-a-promising-approach-to-identify-candidate-autism-genes
#6
Anika Gupta, Min Woo Sun, Kelley Marie Paskov, Nate Tyler Stockham, Jae-Yoon Jung, Dennis Paul Wall
Despite mounting evidence for the strong role of genetics in the phenotypic manifestation of Autism Spectrum Disorder (ASD), the specific genes responsible for the variable forms of ASD remain undefined. ASD may be best explained by a combinatorial genetic model with varying epistatic interactions across many small effect mutations. Coalitional or cooperative game theory is a technique that studies the combined effects of groups of players, known as coalitions, seeking to identify players who tend to improve the performance--the relationship to a specific disease phenotype--of any coalition they join...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29039247/high-throughput-in-silico-identification-and-characterization-of-plasmodium-falciparum-prl-phosphatase-inhibitors
#7
Rajan Pandey, Rakesh Kumar, Priya Gupta, Asif Mohmmed, Rita Tewari, Pawan Malhotra, Dinesh Gupta
Kinases and phosphatases are involved in many essential processes in Plasmodium life cycle. Among the identified 67 Plasmodium falciparum phosphatases, Phosphatase of Regenerating Liver (PRL) family protein homolog, PfPRL is an essential parasite tyrosine phosphatase. PfPRL is shown to be prenylated, secreted and involved in the host invasion process. In the present study, a structure based high throughput in-silico screening of PfPRL binders, using ChEMBL-NTD compounds lead to the identification of nine compounds based on binding energy, Lipinski rule of five and QED score...
October 17, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28941736/a-prognostic-tool-to-predict-outcomes-in-children-undergoing-the-norwood-operation
#8
Punkaj Gupta, Avishek Chakraborty, Jeffrey M Gossett, Mallikarjuna Rettiganti
OBJECTIVES: To create and validate a prediction model to assess outcomes associated with the Norwood operation. METHODS: The public-use dataset from a multicenter, prospective, randomized single-ventricle reconstruction trial was used to create this novel prediction tool. A Bayesian lasso logistic regression model was used for variable selection. We used a hierarchical framework by representing discrete probability models with continuous latent variables that depended on the risk factors for a particular patient...
August 30, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28872226/prebiopsy-multiparametric-mri-based-risk-score-for-predicting-prostate-cancer-in-biopsy-naive-men-with-prostate-specific-antigen-between-4-10%C3%A2-ng-ml
#9
Durgesh Kumar Dwivedi, Rajeev Kumar, Alok Kumar Dwivedi, Girdhar S Bora, Sanjay Thulkar, Sanjay Sharma, Siddhartha Datta Gupta, Naranamangalam R Jagannathan
BACKGROUND: Risk calculators have traditionally utilized serum prostate-specific antigen (PSA) values in addition to clinical variables to predict the likelihood of prostate cancer (PCa). PURPOSE: To develop a prebiopsy multiparametric MRI (mpMRI)-based risk score (RS) and a statistical equation for predicting the risk of PCa in biopsy-naive men with serum PSA between 4-10 ng/mL that may help reduce unnecessary biopsies. STUDY TYPE: Prospective cross-sectional study...
September 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28797611/video-instruction-is-more-effective-than-written-instruction-in-improving-inhaler-technique
#10
Romil F Shah, Rakesh M Gupta
INTRODUCTION: Many patients with asthma use inhalers incorrectly. Better inhaler technique is associated with better asthma control. We tested the effectiveness of a computer-based video training solution versus traditional written instructions, both which may be used in a resource-limited setting, for teaching inhaler technique. We hypothesized that computer based training will provide a higher quality of instruction which will improve technique more effectively than written training...
October 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28729297/association-between-intracranial-atherosclerotic-calcium-burden-and-angiographic-luminal-stenosis-measurements
#11
H Baradaran, P Patel, G Gialdini, A Giambrone, M P Lerario, B B Navi, J K Min, C Iadecola, H Kamel, A Gupta
BACKGROUND AND PURPOSE: Calcification of the intracranial vasculature is an independent risk factor for stroke. The relationship between luminal stenosis and calcium burden in the intracranial circulation is incompletely understood. We evaluated the relationship between atherosclerotic calcification and luminal stenosis in the intracranial ICAs. MATERIALS AND METHODS: Using a prospective stroke registry, we identified patients who had both NCCT and CTA or MRA examinations as part of a diagnostic evaluation for ischemic stroke...
July 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28688017/what-factors-predict-conversion-to-tha-after-arthroscopy
#12
John M Redmond, Asheesh Gupta, Kevin Dunne, Ammar Humayun, Leslie C Yuen, Benjamin G Domb
BACKGROUND: Failure of hip preservation to alleviate symptoms potentially subjects the patient to reoperation or conversion surgery to THA, adding recovery time, risk, and cost. A risk calculator using an algorithm that can predict the likelihood that a patient who undergoes arthroscopic hip surgery will undergo THA within 2 years would be helpful, but to our knowledge, no such tool exists. QUESTIONS: (1) Are there preoperative and intraoperative variables at the time of hip arthroscopy associated with subsequent conversion to THA? (2) Can these variables be used to develop a predictive tool for conversion to THA? MATERIALS AND METHODS: All patients undergoing arthroscopy from January 2009 through December 2011 were registered in our longitudinal database...
October 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28584536/comparative-assessment-of-salivary-cotinine-level-and-psychological-dependence-among-tobacco-users
#13
Vrushali D Patel, Kiran B Jadhav, Vandana S Shah, Nidhi D Gupta
BACKGROUND: The aim of the study was to assess the correlation between salivary cotinine level and psychological dependence measured through Fagerstrom test for nicotine dependence (FTND) questionnaire among tobacco users. MATERIALS AND METHODS: This was a cross-sectional study, conducted on tobacco users. Participants with the present habit of tobacco chewing and smoking above the age of 16 years were included in the study. A standard questionnaire form of FTND revised version for smoking and smokeless form of tobacco were given to each participant...
March 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28584513/assessment-of-panc3-score-in-predicting-severity-of-acute-pancreatitis
#14
Avreen Singh Shah, Arun Kumar Gupta, Kulwant Singh Ded
INTRODUCTION: Acute pancreatitis is inflammatory process of the pancreas associated with local and systemic complications. At present, there are lots of scores (such as Ransons, APACHE II, bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission but these are time consuming or require complex calculation and are costly. MATERIAL AND METHODS: PANC3 Scoring System is one of the better systems because the three criteria used (hematocrit, body mass index, and pleural effusion) are simple, easy to assess, readily available, and economic...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/28577684/electronically-self-assessed-functional-capacity-and-exercise-testing-a-comparison-of-the-duke-activity-status-index-and-patient-reported-outcomes-measurement-information-system-tools
#15
COMPARATIVE STUDY
Ryan A Coute, Jesse M Ehrenfeld, Deepak K Gupta, Maxim A Terekhov, Jonathan P Wanderer
PURPOSE: Electronic screening tools, such as Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short-Form 12a (PF-SF12a), may aid in the assessment of functional capacity. However, PROMIS PF-SF12a has not been validated against exercise capacity, or compared with established questionnaires, including the Duke Activity Status Index (DASI). We compared the DASI and PROMIS PF-SF12a to the maximum metabolic equivalents (METs) achieved during exercise stress testing...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28373450/human-papilloma-virus-positive-oropharyngeal-squamous-cell-carcinoma-in-the-elderly
#16
Eesha Dave, William Su, Vishal Gupta, Brett Miles, Elizabeth Demicco, Theresa Soriano, Richard L Bakst
BACKGROUND/AIM: Elderly patients with HPV+ oropharyngeal cancer (OPC) represent an understudied cohort of the HPV epidemic. We aimed to investigate the clinical presentation, treatment tolerability and outcomes in patient's ≥65 years old with HPV+ OPC. PATIENTS AND METHODS: We identified all patients aged 65 and older treated at our Institution with HPV+ OPC and analyzed patient demographics, disease characteristics, treatment modalities, toxicities, treatment failures, and survival...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28346595/association-of-gastric-acid-suppression-with-recurrent-clostridium-difficile-infection-a-systematic-review-and-meta-analysis
#17
REVIEW
Raseen Tariq, Siddharth Singh, Arjun Gupta, Darrell S Pardi, Sahil Khanna
Importance: Gastric acid suppression has been associated with an increased risk of primary Clostridium difficile infection (CDI), but the risk of recurrent CDI in patients taking gastric acid suppressant medications is unclear. Objective: To perform a systematic review and meta-analysis to evaluate the association between gastric acid suppressants and recurrent CDI. Data Sources: MEDLINE, EMBASE, the Cochrane Central Register, the Cochrane Database, and Web of Science were searched from January 1, 1995, to September 30, 2015, for studies assessing the association between gastric acid suppressant exposure and recurrent CDI...
June 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28190702/analysis-of-low-appropriateness-score-exam-trends-in-decision-support-based-radiology-order-entry-system
#18
Supriya Gupta, Kandace Klein, Anand H Singh, James H Thrall
PURPOSE: Awareness of imaging utilization increased after implementation of Radiology Order Entry with decision support systems (ROE-DS). Our hypothesis is few exams with low Clinical Appropriateness Score (CAS) on ROE-DS are performed. Clinical indications of exams with CAS less than 3 (9-point scale) were re-reviewed and reports analyzed. MATERIALS AND METHODS: Structured Query Language-based query retrieved exams with CAS less than 3 in ROE-DS from January 2007 to December 2011...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28048293/su-f-t-605-implementation-of-the-conformity-gradient-index-cgi-to-intracranial-linac-based-stereotactic-plans-to-evaluate-possible-improvements-in-treatment-planning
#19
A Sandu, S Thompson, A Ayan, J Woollard, N Gupta
PURPOSE: To retrospectively evaluate the planning quality of a sample of intracranial, linac-based, dynamic arc MLC and VMAT stereotactic plans by calculating the effective gradient, Conformity Score (CGIc) and Gradient Score Index (CGIg), and determine if the Conformity/Gradient Index (CGI) may be a useful metric to guide our current treatment planning process. METHODS: We evaluated single lesion VMAT, single lesion dynamic arc, and single isocenter, 2-lesion linac-based, intracranial, VMAT treatment plans originally created in Eclipse™...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031730/improving-quality-of-home-based-postnatal-care-by-microteaching-of-multipurpose-workers-in-rural-and-urban-slum-areas-of-chandigarh-india-a-pilot-study
#20
Madhu Gupta, Jaya Prasad Tripathy, Limalemla Jamir, Ashutosh Sarwa, Smita Sinha, Chering Bhag
BACKGROUND: Microteaching is an efficient teaching tool to improve skills. Until now, its use is very limited in the health sector. A pilot study was carried out to improve the quality of home-based postnatal care by microteaching of health workers (HWs) and ascertain its feasibility for supportive supervision. METHODS: All (n=12) the HWs catering to a population of ~0.1 million were video recorded while performing home-based postnatal check up in Chandigarh from August 2013 to December 2014...
2017: Advances in Medical Education and Practice
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