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James Buxbaum, Michael Quezada, Bradford Chong, Nikhil Gupta, Chung Yao Yu, Christianne Lane, Ben Da, Kenneth Leung, Ira Shulman, Stephen Pandol, Bechien Wu
OBJECTIVES: The Pancreatitis Activity Scoring System (PASS) has been derived by an international group of experts via a modified Delphi process. Our aim was to perform an external validation study to assess for concordance of the PASS score with high face validity clinical outcomes and determine specific meaningful thresholds to assist in application of this scoring system in a large prospectively ascertained cohort. METHODS: We analyzed data from a prospective cohort study of consecutive patients admitted to the Los Angeles County Hospital between March 2015 and March 2017...
March 15, 2018: American Journal of Gastroenterology
Rohit A Gupta, Meha N Motiwala, Ujawala N Mahajan, Sapna S Sabare
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Sesbania grandiflora (Linn) belonging to the family Fabaceae is commonly known as sesbania, agathi, and katurai. The plant is accredited for alleviating a spectrum of ailments including inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, bronchitis, convulsion and anxiety. It is also used as antitumour, anthelmintic, and laxatives in Ayurveda and Siddha system of Indian traditional medicine. AIM: To reveal protective effect of Sesbania grandiflora in acetic acid induced ulcerative colitis in mice...
March 9, 2018: Journal of Ethnopharmacology
Nupur Gupta, Jay B Wish
The US End Stage Renal Disease (ESRD) Program, which came into existence in 1973, was initially envisioned to provide needed financial coverage for about 50 000 patients through Medicare. Over the past 45 years the evolution of the ESRD program has been quite different, and it now serves over one half million dialysis and transplant patients. The Medicare Improvements for Patients and Providers Act (MIPPA) of 2008 Section 153(c) requires the Centers for Medicare and Medicaid Services (CMS) to develop and implement quality measures for dialysis patients as part of the ESRD Quality Incentive Program (QIP) beginning in payment year (PY) 2012...
February 26, 2018: Seminars in Dialysis
Alexandre Dumusc, Wan-Fai Ng, Katherine James, Bridget Griffiths, Elizabeth Price, Colin Pease, Paul Emery, Peter Lanyon, Adrian Jones, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, Monica Gupta, John McLaren, Annie Cooper, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Francesca Barone, Benjamin Fisher, Saaeha Rauz, Andrea Richards, Simon Bowman
OBJECTIVES: To assess the use of the Clinical EULAR Sjögren's Syndrome Disease Activity Index (ClinESSDAI), a version of the ESSDAI without the biological domain, for assessing potential eligibility and outcomes for clinical trials in patients with primary Sjögren's syndrome (pSS), according to the new ACR-EULAR classification criteria, from the UK Primary Sjögren's Syndrome Registry (UKPSSR). METHODS: A total of 665 patients from the UKPSSR cohort were analysed at their time of inclusion in the registry...
February 14, 2018: Swiss Medical Weekly
Anish Gupta, Deven Juneja, Omender Singh, Suneel Kumar Garg, Varun Arora, Desh Deepak
Objective: Chikungunya is generally a mild disease, rarely requiring Intensive Care Unit (ICU) admission. However, certain populations may develop organ dysfunction necessitating ICU admission. The purpose of the study was to assess the clinical profile and course of chikungunya patients admitted to the ICU, and to ascertain factors linked with poor outcome. Methods: All patients with chikungunya admitted to ICU were included in the study. Admission Acute Physiology and Chronic Health Evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score were calculated...
January 2018: Indian Journal of Critical Care Medicine
C S Manohar, Avneet Gupta, R Keshavamurthy, M Shivalingaiah, B R Sharanbasappa, Vinish Kumar Singh
Background: Testicular torsion is one of the causes of acute scrotum and it requires timely evaluation and surgical treatment. Color Doppler is considered investigation of choice, but it may delay treatment, as, many times, it may not be available for emergency situations. Barbosa et al. created Testicular Workup for Ischemia and Suspected Torsion (TWIST) score based on clinical parameters for clinical diagnosis of testicular torsion. We have evaluated this score in our population. Materials and Methods: We retrospectively calculated TWIST score in patients of acute scrotum admitted to tertiary teaching institute...
January 2018: Urology Annals
Shweta Gupta, Mohammad Javed Ali, Mohammad Hasnat Ali, Milind N Naik
PURPOSE: The objective of this study was to assess the quality of outcomes of mini-Monoka stent dilatation for punctal stenosis using the lacrimal symptom (Lac-Q) questionnaire. METHODS: Prospective interventional case series of 45 eyes of 25 consecutive patients who underwent mini-Monoka stent dilatation for primary punctal stenosis were included in the study. The stents were extubated at 4 weeks. The Lac-Q questionnaire was administered preoperatively and at 12 weeks and 24 weeks following the intervention...
February 2018: Indian Journal of Ophthalmology
Kunwarpal Singh, Kamlesh Gupta, Sukhdeep Kaur
Aim of the study: High-resolution ultrasonography of the tibial nerve is a fast and non invasive tool for diagnosis of diabetic peripheral neuropathy. Our study was aimed at finding out the correlation of the cross sectional area and maximum thickness of nerve fascicles of the tibial nerve with the presence and severity of diabetic peripheral neuropathy. Material and methods: 75 patients with type 2 diabetes mellitus clinically diagnosed with diabetic peripheral neuropathy were analysed, and the severity of neuropathy was determined using the Toronto Clinical Neuropathy Score...
December 2017: Journal of Ultrasonography
Punkaj Gupta, Mallikarjuna Rettiganti, Andrew Wilcox, Mai-Anh Vuong-Dac, Jeffrey M Gossett, Michiaki Imamura, Avishek Chakraborty
OBJECTIVES: To empirically derive an inotrope score to predict real-time outcomes using the doses of inotropes after pediatric cardiac surgery. The outcomes evaluated included in-hospital mortality, prolonged hospital length of stay (LOS), and composite poor outcome (mortality and/or prolonged hospital LOS). METHODS: The study population included patients <18 years of age undergoing heart operations (with or without cardiopulmonary bypass) of varying complexity...
January 19, 2018: Seminars in Thoracic and Cardiovascular Surgery
Supriya Gupta, Ronald S Arellano, Debra A Gervais, Dushyant V Sahani
OBJECTIVE: This study assessed radiation dose after CT-guided percutaneous radiofrequency ablations (RFAs) of hepatic and renal tumors and the effect of weight-based CT protocol modification for lowering overall dose in these procedures. MATERIALS AND METHODS: CT-guided RFA for renal and hepatic ablations performed from January 1, 2009, through December 31, 2009, were retrospectively reviewed (90 men and 48 women; age, 42-81 years). The radiation dose was recorded during each of the following steps: planning, performing, and postprocedure...
January 11, 2018: AJR. American Journal of Roentgenology
Nancy A Pike, Bhaswati Roy, Ritika Gupta, Sadhana Singh, Mary A Woo, Nancy J Halnon, Alan B Lewis, Rajesh Kumar
BACKGROUND: Single ventricle heart disease (SVHD) adolescents show cognitive impairments and anxiety and depressive symptoms, indicating the possibility of brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites in SVHD remains unclear. We examined brain tissue changes in SVHD compared to controls using T2-relaxometry procedures, which measure free water content and show tissue injury. METHODS: Proton-density and T2-weighted images, using a 3...
January 6, 2018: Journal of Neuroscience Research
Tejasav Sehrawat, Anuraag Jindal, Paaras Kohli, Amit Thour, Jasbinder Kaur, Atul Sachdev, Yashdeep Gupta
INTRODUCTION: To study the utility of glycated hemoglobin (HbA1c) in the diagnosis of diabetes in patients with cirrhosis as compared to the gold standard oral glucose tolerance test (OGTT) and to see the effect of anemia and severity of cirrhosis on its performance. METHODS: Individuals (n = 100) with an established diagnosis of liver cirrhosis were recruited. The OGTT was performed as described by the World Health Organization (WHO). The severity of cirrhosis was calculated using the Child-Turcotte-Pugh (CTP) score...
January 5, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Seng Chua, Sarika Gupta, Jennifer Curnow, Beata Gidaszewski, Marjan Khajehei, Hayley Diplock
BACKGROUND: Acute post-partum anaemia can be associated with significant morbidity including a predisposition for postnatal depression. Lack of clear practice guidelines means a number of women are treated with multiple blood transfusions. Intravenous iron has the potential to limit the need for multiple blood transfusions but its role in the post-partum setting is unclear. METHODS/DESIGN: IIBAPPA is a multi-centre randomised non-inferiority trial. Women with a primary post-partum haemorrhage (PPH) >1000 mL and resultant haemoglobin (Hb) 5...
December 19, 2017: BMC Pregnancy and Childbirth
Anju Seth, Rajeev Kumar Malhotra, Rohini Gupta, Jagdish Chandra, Praveen Kumar, Sarita Singh, Garima Sharma
BACKGROUND: Children living with HIV (CLHIV) commonly experience growth failure. We report growth parameters in CLHIV at baseline and during 3 years of antiretroviral therapy (ART). METHODS: Records of CLHIV who had completed at least 3 years on ART were reviewed after excluding subjects who died, were lost to follow-up or developed treatment failure to assess impact of sustained administration of ART. Height-for-age (HFA) and body mass index for age (BFA) Z scores were calculated, and proportion of CLHIV with wasting and stunting estimated at baseline, 6, 12, 24 and 36 months after starting ART using the linear mixed model...
January 2018: Pediatric Infectious Disease Journal
Anika Gupta, Min Woo Sun, Kelley Marie Paskov, Nate Tyler Stockham, Jae-Yoon Jung, Dennis Paul Wall
Despite mounting evidence for the strong role of genetics in the phenotypic manifestation of Autism Spectrum Disorder (ASD), the specific genes responsible for the variable forms of ASD remain undefined. ASD may be best explained by a combinatorial genetic model with varying epistatic interactions across many small effect mutations. Coalitional or cooperative game theory is a technique that studies the combined effects of groups of players, known as coalitions, seeking to identify players who tend to improve the performance--the relationship to a specific disease phenotype--of any coalition they join...
2018: Pacific Symposium on Biocomputing
Rajan Pandey, Rakesh Kumar, Priya Gupta, Asif Mohmmed, Rita Tewari, Pawan Malhotra, Dinesh Gupta
Kinases and phosphatases are involved in many essential processes in Plasmodium life cycle. Among the identified 67 Plasmodium falciparum phosphatases, Phosphatase of Regenerating Liver (PRL) family protein homolog, PfPRL is an essential parasite tyrosine phosphatase. PfPRL is shown to be prenylated, secreted and involved in the host invasion process. In the present study, a structure based high throughput in-silico screening of PfPRL binders, using ChEMBL-NTD compounds lead to the identification of nine compounds based on binding energy, Lipinski rule of five and QED score...
October 17, 2017: Journal of Biomolecular Structure & Dynamics
Punkaj Gupta, Avishek Chakraborty, Jeffrey M Gossett, Mallikarjuna Rettiganti
OBJECTIVES: To create and validate a prediction model to assess outcomes associated with the Norwood operation. METHODS: The public-use dataset from a multicenter, prospective, randomized single-ventricle reconstruction trial was used to create this novel prediction tool. A Bayesian lasso logistic regression model was used for variable selection. We used a hierarchical framework by representing discrete probability models with continuous latent variables that depended on the risk factors for a particular patient...
August 30, 2017: Journal of Thoracic and Cardiovascular Surgery
Durgesh Kumar Dwivedi, Rajeev Kumar, Alok Kumar Dwivedi, Girdhar S Bora, Sanjay Thulkar, Sanjay Sharma, Siddhartha Datta Gupta, Naranamangalam R Jagannathan
BACKGROUND: Risk calculators have traditionally utilized serum prostate-specific antigen (PSA) values in addition to clinical variables to predict the likelihood of prostate cancer (PCa). PURPOSE: To develop a prebiopsy multiparametric MRI (mpMRI)-based risk score (RS) and a statistical equation for predicting the risk of PCa in biopsy-naive men with serum PSA between 4-10 ng/mL that may help reduce unnecessary biopsies. STUDY TYPE: Prospective cross-sectional study...
September 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
Romil F Shah, Rakesh M Gupta
INTRODUCTION: Many patients with asthma use inhalers incorrectly. Better inhaler technique is associated with better asthma control. We tested the effectiveness of a computer-based video training solution versus traditional written instructions, both which may be used in a resource-limited setting, for teaching inhaler technique. We hypothesized that computer based training will provide a higher quality of instruction which will improve technique more effectively than written training...
October 2017: Pulmonary Pharmacology & Therapeutics
H Baradaran, P Patel, G Gialdini, A Giambrone, M P Lerario, B B Navi, J K Min, C Iadecola, H Kamel, A Gupta
BACKGROUND AND PURPOSE: Calcification of the intracranial vasculature is an independent risk factor for stroke. The relationship between luminal stenosis and calcium burden in the intracranial circulation is incompletely understood. We evaluated the relationship between atherosclerotic calcification and luminal stenosis in the intracranial ICAs. MATERIALS AND METHODS: Using a prospective stroke registry, we identified patients who had both NCCT and CTA or MRA examinations as part of a diagnostic evaluation for ischemic stroke...
July 20, 2017: AJNR. American Journal of Neuroradiology
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