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Mary McGunigal, Jerry Liu, Tamara Kalir, Manjeet Chadha, Vishal Gupta
OBJECTIVES: High-risk histology including UPSC, CC, and high-grade (G3) endometrioid adenocarcinoma (EAC) have a worse prognosis compared to G1-2 EAC. It is unknown whether G3EAC outcomes are more similar to UPSC/CC or to G1-2 EAC. The purpose of this study was to compare overall survival (OS) among UPSC, CC, and G1-3 EAC, for International Federation of Gynecology and Obstetrics stages I to III. METHODS: The National Cancer Data Base was queried for patients diagnosed with International Federation of Gynecology and Obstetrics (1988 classification) Stage I-III UPSC, CC, and EAC from 1998 to 2012 who underwent surgery as definitive treatment...
October 18, 2016: International Journal of Gynecological Cancer
Prasenjit Das, Ramakant Rawat, Anil K Verma, Geetika Singh, Archana G Vallonthaiel, Rajni Yadav, Gaurav P S Gahlot, Amit K Dinda, Vineet Ahuja, Siddhartha Datta Gupta, Sanjay K Agarwal, Govind K Makharia
Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement in CeD, tissue blocks of patients with IgA nephropathies (IgAN), minimal change disease, membranous glomerulonephritis, membrano-proliferative glomerulonephritis, normal kidney, intestinal biopsies from CeD, tropical sprue, nonspecific duodenitis, and inflammatory bowel disease; liver biopsies from patients with chronic hepatitis B and C, acute liver failure (ALF), and CeD-associated liver diseases were retrieved and subjected to IHC staining for anti-tissue transglutaminase 2 enzyme...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Rajni Yadav, Saurav Chopra, Aayushi Garg, Brijnandan Gupta, Prateek Kinra, Siddhartha Datta Gupta, Prasenjit Das
BACKGROUND: Hepatocyte Paraffin 1 (Hep Par 1) was being extensively used to recognize the hepatocellular carcinomas, until recognition of its expression in tumors without hepatocellular differentiation. AIMS AND OBJECTIVES: The aim of this study was to analyze if Hep Par 1 stain can serve as a specific marker of the small intestinal (SI) adenocarcinomas, versus other gastrointestinal tract (GIT) primary tumors. MATERIALS AND METHODS: In this retrospective cross-sectional study, normal GIT mucosa (n - 60), corresponding adenocarcinomas (n - 60) and nodal metastatic foci (n - 60) from the same patients, including 10 cases each from the esophagus, stomach, SI periampullary region, colon, rectum, and gall bladder were included...
October 2016: Indian Journal of Pathology & Microbiology
Nobhojit Roy, Martin Gerdin, Eric Schneider, Deepa K Kizhakke Veetil, Monty Khajanchi, Vineet Kumar, Makhal Lal Saha, Satish Dharap, Amit Gupta, Göran Tomson, Johan von Schreeb
INTRODUCTION: In the Lower-Middle Income Country setting, we validate trauma severity scoring systems, namely Injury Severity Score (ISS), New Injury Severity Scale (NISS) score, the Kampala Trauma Score (KTS), Revised Trauma Score (RTS) score and the TRauma Injury Severity Score (TRISS) using Indian trauma patients. PATIENTS AND METHODS: From 1 September 2013 to 28 February 2015, we conducted a prospective multi-centre observational cohort study of trauma patients in four Indian university hospitals, in three megacities, Kolkata, Mumbai and Delhi...
September 20, 2016: Injury
Bill Pass, Maria Johnson, Elizabeth M A Hensor, Harun Gupta, Philip Robinson
OBJECTIVES: To evaluate quantitative sonoelastography of benign and malignant musculoskeletal soft tissue masses. METHODS: We conducted a prospective study of 50 patients from a specialist sarcoma center who had extremity soft tissue masses referred for biopsy. After consent, the quantitative shear wave velocity (meters per second) was measured in longitudinal and transverse planes (3 readings in each plane and mean calculated). All masses subsequently underwent biopsy, excision, or both, with the histologic diagnosis taken as the reference standard...
October 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Chakor S Vora, Niteen D Karnik, Vishal Gupta, Milind Y Nadkar, Jaimala V Shetye
INTODUCTION: An increasing number of patients require mechanical ventilation and there has been a proportional increase in patients needing prolonged mechanical ventilation (ventilated for ≥ 21 days, for atleast 6 hours per day). It accounts for about 10% of all mechanically ventilated patients. Although these patients represent a smaller proportion of intensive care unit (ICU) patients, they consume substantial ICU resources. We studied etiology, metabolic and clinical profile, complications and outcome of these patients...
October 2015: Journal of the Association of Physicians of India
Davide Bellini, Sonia Gupta, Juan Carlos Ramirez-Giraldo, Wanyi Fu, Sandra S Stinnett, Bhavik Patel, Achille Mileto, Daniele Marin
PURPOSE: To investigate the impact of a second-generation noise-optimized monoenergetic algorithm on selection of the optimal energy level, image quality, and effect of patient body habitus for dual-energy multidetector computed tomography of the pancreas. MATERIALS AND METHODS: Fifty-nine patients (38 men, 21 women) underwent dual-energy multidetector computed tomography (80/Sn140 kV) in the pancreatic parenchymal phase. Image data sets, at energy levels ranging from 40 to 80 keV (in 5-keV increments), were reconstructed using first-generation and second-generation noise-optimized monoenergetic algorithm...
August 25, 2016: Journal of Computer Assisted Tomography
Rita D Page, Sumeet K Gupta, Thomas L Jenkins, Zeynel A Karcioglu
PURPOSE: The aim of this study was to identify the risk factors that are predictive of poor outcomes in penetrating globe trauma. PATIENTS AND METHODS: This retrospective case series evaluated 103 eyes that had been surgically treated for an open-globe injury from 2007 to 2010 at the eye clinic of the University of Virginia. A total of 64 eyes with complete medical records and at least 6 months of follow-up were included in the study. Four risk factors (preoperative best-corrected visual acuity [pre-op BCVA], ocular trauma score [OTS], zone of injury [ZOI], and time lapse [TL] between injury and primary repair) and three outcomes (final BCVA, monthly rate of additional surgeries [MRAS], and enucleation) were identified for analysis...
2016: Clinical Ophthalmology
Bryan M Saltzman, Brandon J Erickson, Joshua D Harris, Anil K Gupta, Mark Mighell, Anthony A Romeo
BACKGROUND: Proximal humerus fractures are common problems plaguing the elderly population. PURPOSE: The purposes of this study were to determine the outcomes of fibular strut allografts in treatment of proximal humerus fractures with open reduction internal fixation (ORIF) and to present the authors' preferred surgical technique. The hypothesis was that the use of fibular strut allografts in treating proximal humerus fractures with ORIF will provide low reoperation rates with acceptable outcomes...
July 2016: Orthopaedic Journal of Sports Medicine
Sameer Raghuwanshi, Rajesh Gupta, Mahendra Mohan Vyas, Rakesh Sharma
INTRODUCTION: Pancreatitis is one of most complex and clinically challenging of all abdominal disorders. USG and abdominal CT are the most commonly used diagnostic imaging modalities for the evaluation of pancreas. Computed Tomography (CT) is highly accurate and sensitive than USG in both diagnosing as well as demonstrating the extent. Early assessment of the cause and severity of acute pancreatitis is of utmost importance for prompt treatment and close monitoring of patient with severe disease...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Jason A Hugentobler, Resmi Gupta, Robert Slater, Mark V Paterno, Michael A Riley, Catherine Quatman-Yates
OBJECTIVE: To examine the influence of age, sex, attention-deficit hyperactivity disorder (ADHD) status, previous history of concussion, and days since injury on postconcussion postural control assessment in adolescents who have suffered a concussion. DESIGN: Prospective cohort study. SETTING: Hospital-based outpatient clinic. PARTICIPANTS: Seventy-one participants (42 males; 29 females) with mean age 14.14 ± 2.44. INDEPENDENT VARIABLES: Age, sex, previous concussion history, ADHD status, total and severity of postconcussion symptoms, and days since injury...
June 22, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Sounak Gupta, Jun Zhang, Michael Rivera, Lori A Erickson
Paragangliomas of the urinary bladder can arise sporadically or as a part of hereditary syndromes including those with underlying mutations in the succinate dehydrogenase (SDH) genes, which serve as tumor suppressors. SDH deficiency can be screened for by absence of immunohistochemical detection of SDHB. In this study of 11 cases, clinical follow-up was available for 9/11 cases. The cases were reviewed and graded based on the grading system for adrenal pheochromocytomas and paragangliomas (GAPP) criteria. Immunohistochemistry was performed for Ki67 and SDHB...
September 2016: Endocrine Pathology
Vishal Gupta, Madhu Mati Goel, Abhijit Chandra, Parul Gupta, Saket Kumar, Jaya Nigam
BACKGROUND: Clinical significance of survivin (antiapoptosis protein) in gallbladder cancer is not yet established. AIMS: This study was performed to assess the expression pattern of survivin in benign and malignant gallbladder lesions using immunohistochemistry (IHC), and to assess its clinicopathological significance. SETTINGS AND DESIGN: Prospective study from July 2012 to July 2014 was performed as a part of intramural research project...
April 2016: Indian Journal of Pathology & Microbiology
Mamta Gupta, Ana Babic, Andrew H Beck, Kathryn Terry
Inflammatory cytokines, like tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), are elevated in ovarian cancer. Differences in cytokine expression by histologic subytpe or ovarian cancer risk factors can provide useful insight into ovarian cancer risk and etiology. We used ribonucleic acid in situ hybridization to assess TNF-α and IL-6 expression on tissue microarray slides from 78 epithelial ovarian carcinomas (51 serous, 12 endometrioid, 7 clear cell, 2 mucinous, 6 other) from a population-based case-control study...
August 2016: Human Pathology
Richard Hostin, Chessie Robinson, Michael O'Brien, Christopher Ames, Frank Schwab, Justin S Smith, Virginie Lafage, Munish Gupta, Robert Hart, Douglas Burton, Shay Bess, Christopher Schaffrey, Ian McCarthy
STUDY DESIGN: Multicenter, retrospective analysis, prospective database, consecutive case series. OBJECTIVE: This study examines multicenter variability in patient-level surgical resource use, including implants, biologics, and length of stay (LOS), alongside health-related quality-of-life (HRQoL) improvements after adult spinal deformity (ASD) surgery. SUMMARY OF BACKGROUND DATA: Efficiency in surgical resource use is critical to high-value health care...
April 2016: Spine
Himanshu Sekhar Mahapatra, Yadunanandan Prasad Gupta, Neera Sharma, Gurdeep Buxi
Chronic kidney disease (CKD) has attained epidemic proportions in India due to increased incidence of diabetes and hypertension (HTN). It was surmised that identification of only high-risk groups (HRGs) through a questionnaire would be sufficient to identify cases of kidney damage (KD). The study attempted to device a questionnaire to classify the subjects in to HRG and low-risk group (LRG) and assess the extent of early KD. The central government employees were classified into HRG and LRG based on "SCreening for Occult REnal Disease (SCORED)" and "EXTENDED" questionnaire formulated after addition of 10 more parameters apart from diabetes and HTN...
March 2016: Saudi Journal of Kidney Diseases and Transplantation
Ram Kumar Solanki, Ashok Kumar, Yogesh Satija, Suresh Gupta, Paramjeet Singh
CONTEXT: Multiple vulnerability genes interact with environmental factors to develop a range of phenotypes in the schizophrenia spectrum. Endophenotypes can help characterize the impact of risk genes by providing genetically relevant traits that are more complaisant than the behavioral symptoms that classify mental illness. AIMS: We aimed to investigate the neurocognitive endophenotypic markers for schizophrenia in Indian population. SETTINGS AND DESIGN: In a cross-sectional study, we assessed neurocognitive functioning in 40 unaffected first-degree relatives (FDR) of schizophrenia patients with an equal number of healthy controls...
January 2016: Indian Journal of Psychiatry
Sarvjeet Kaur, Kewal Krishan Gupta, Amanjot Singh, Sunita, Naresh Baghla
BACKGROUND AND AIM: Dexmedetomidine and clonidine are commonly used drugs for sedation during regional anesthesia. However, data regarding arousal time from sedation with these drugs is sparse. Hence, we designed a study to compare arousal time from sedation with dexmedetomidine and clonidine during spinal anesthesia. We also tried to find out the correlation between clinical and objective method used for assessing the depth of sedation. MATERIALS AND METHODS: In this study, 120 patients were randomly assigned in two groups to receive either dexmedetomidine (Group DE, n = 60) or Clonidine (Group CL, n = 60)...
January 2016: Anesthesia, Essays and Researches
Deepak K Gupta, Raghav Singla, Shashank S Kale, Bhawani S Sharma
CONTEXT: Traumatic brain injury (TBI) remains a major cause of morbidity and mortality worldwide. Largely, the prognosis is dependent on the nonmodifiable factors such as severity of the initial injury, Glasgow coma scale score, pupillary response, age, and presence of additional physiological derangements such as hypoxia or hypotension. However, secondary insults continue to take place after the initial injury and resuscitation. The study hypothesis in the present research article was that hypoglycemia is an independent outcome prognosticator in severe traumatic brain injury...
March 2016: Neurology India
Rupjyoti Talukdar, Sundeep Lakhtakia, D Nageshwar Reddy, G Venkat Rao, Rebala Pradeep, Rupa Banerjee, Rajesh Gupta, Mohan Ramchandani, Manu Tandan, H Vivekananda Murthy
BACKGROUND AND AIM: The aim of this study was to evaluate the effect of antioxidant-pregabalin combination on pain recurrence in patients with chronic calcific pancreatitis. METHODS: In this randomized, double-blind, placebo-controlled trial, chronic calcific pancreatitis patients with pain recurrence following pancreatic ductal clearance of stones received either antioxidant-pregabalin combination or matching placebo for 2 months followed by open-label antioxidants for the next 4 months in both groups...
September 2016: Journal of Gastroenterology and Hepatology
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