keyword
https://read.qxmd.com/read/38528739/cognitive-and-emotional-impairment-in-stroke-survivors-insights-from-a-multi-center-study-on-inpatient-rehabilitation-therapy
#21
JOURNAL ARTICLE
Lihua Jin, Ying Zhao, Ting Ye, Ying He, Liqing Yao
BACKGROUND: Individuals recovering from stroke often experience cognitive and emotional impairments, but rehab programs tend to focus on motor skills. The aim of this investigation is to systematically assess the change of magnitude of cognitive and emotional function subsequent to a conventional rehabilitative protocol administered to stroke survivors within a defined locale in China. METHODS: This is a multicenter study; a total of 1884 stroke survivors who received in-hospital rehabilitation therapy were assessed on admission (T0) and discharge (T1)...
March 25, 2024: Brain Injury
https://read.qxmd.com/read/38528668/investigating-the-safety-profiles-of-exogenous-melatonin-and-associated-adverse-events-a-pharmacovigilance-study-using-who-vigibase
#22
JOURNAL ARTICLE
Minyoung Ha, Dongwon Yoon, Chae-Young Lee, Mose Lee, Young-Wook Kim, Jung-Min Lee, Ju-Young Shin
Melatonin, a pineal hormone that modulates circadian rhythms, sleep, and neurotransmitters, is widely used to treat sleep disorders. However, there are limited studies on the safety of melatonin. Therefore, we aimed to present the overall patterns of adverse events (AEs) following melatonin administration and identify potential safety signals associated with melatonin. Using VigiBase, a global individual case safety report (ICSRs) database managed by the World Health Organization (WHO), we conducted a retrospective, observational, pharmacovigilance study of melatonin between January 1996 and September 2022...
March 2024: Journal of Pineal Research
https://read.qxmd.com/read/38528118/disfunction-of-dorsal-raphe-nucleus-hippocampus-serotonergic-htr3-transmission-results-in-anxiety-phenotype-of-neuroplastin-65-deficient-mice
#23
JOURNAL ARTICLE
Jie Cheng, Ling Chen, Ya-Ni Zheng, Juan Liu, Lei Zhang, Xiao-Ming Zhang, Liang Huang, Qiong-Lan Yuan
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65-/- ) mice exhibit abnormal social and mental behaviors and decreased expression of tryptophan hydroxylase 2 (TPH2) protein. However, whether a causal relationship between TPH2 reduction and anxiety disorders exists needs to be determined. In present study, we found that replenishment of TPH2 in dorsal raphe nucleus (DRN) enhanced 5-HT level in the hippocampus and alleviated anxiety-like behaviors...
March 25, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38528095/effects-of-prenatal-thc-vapor-exposure-on-body-weight-glucose-metabolism-and-feeding-behaviors-in-chow-and-high-fat-diet-fed-rats
#24
JOURNAL ARTICLE
Catherine Hume, Samantha L Baglot, Lucia Javorcikova, Savannah H M Lightfoot, Jessica Scheufen, Matthew N Hill
BACKGROUND: 4-20% of people report using cannabis during pregnancy, thereby it is essential to assess the associated risks. There is some evidence that prenatal cannabis exposure (PCE) may be associated with increased risk for developing of obesity and diabetes later in life, however this has not been well explored under controlled conditions. The aim of this study was to use a translational THC vapor model in rodents to characterize the effects of PCE on adiposity, glucose metabolism, and feeding patterns in adulthood, with focus on potential sex differences...
March 25, 2024: International Journal of Obesity
https://read.qxmd.com/read/38528071/transcriptomic-dysregulation-and-autistic-like-behaviors-in-kmt2c-haploinsufficient-mice-rescued-by-an-lsd1-inhibitor
#25
JOURNAL ARTICLE
Takumi Nakamura, Toru Yoshihara, Chiharu Tanegashima, Mitsutaka Kadota, Yuki Kobayashi, Kurara Honda, Mizuho Ishiwata, Junko Ueda, Tomonori Hara, Moe Nakanishi, Toru Takumi, Shigeyoshi Itohara, Shigehiro Kuraku, Masahide Asano, Takaoki Kasahara, Kazuo Nakajima, Takashi Tsuboi, Atsushi Takata, Tadafumi Kato
Recent studies have consistently demonstrated that the regulation of chromatin and gene transcription plays a pivotal role in the pathogenesis of neurodevelopmental disorders. Among many genes involved in these pathways, KMT2C, encoding one of the six known histone H3 lysine 4 (H3K4) methyltransferases in humans and rodents, was identified as a gene whose heterozygous loss-of-function variants are causally associated with autism spectrum disorder (ASD) and the Kleefstra syndrome phenotypic spectrum. However, little is known about how KMT2C haploinsufficiency causes neurodevelopmental deficits and how these conditions can be treated...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38528035/detecting-abnormal-cell-behaviors-from-dry-mass-time-series
#26
JOURNAL ARTICLE
Romain Bailly, Marielle Malfante, Cédric Allier, Chiara Paviolo, Lamya Ghenim, Kiran Padmanabhan, Sabine Bardin, Jérôme Mars
The prediction of pathological changes on single cell behaviour is a challenging task for deep learning models. Indeed, in self-supervised learning methods, no prior labels are used for the training and all of the information for event predictions are extracted from the data themselves. We present here a novel self-supervised learning model for the detection of anomalies in a given cell population, StArDusTS. Cells are monitored over time, and analysed to extract time-series of dry mass values. We assessed its performances on different cell lines, showing a precision of 96% in the automatic detection of anomalies...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527884/long-term-exposure-to-aryl-hydrocarbon-receptor-agonist-neburon-induces-reproductive-toxicity-in-male-zebrafish-danio-rerio
#27
JOURNAL ARTICLE
Fucong Zhang, Chen Tang, Yue Zhu, Qian Wang, Xin Huang, Chunyan Yang, Chengyong He, Zhenghong Zuo
Neburon is a phenylurea herbicide that is widely used worldwide, but its toxicity is poorly studied. In our previous study, we found that neburon has strong aryl hydrocarbon receptor (AhR) agonist activity, but whether it causes reproductive toxicity is not clear. In the present study, zebrafish were conducted as a model organism to evaluate whether environmental concentrations of neburon (0.1, 1 and 10 µg/L) induce reproductive disorder in males. After exposure to neburon for 150 days from embryo to adult, that the average spawning egg number in high concentration group was 106...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38527507/-analysis-of-9-patients-with-adolescence-onset-methylenetetrahydrofolate-reductase-deficiency
#28
JOURNAL ARTICLE
H T Zhang, X Ma, Y Jin, M Q Li, J Q Song, Z H Chen, Y Liu, X P Lu, H Zheng, Y L Yang
Objective: To explore the diagnosis and treatment of adolescence-onset methylenetetrahydrofolate reductase (MTHFR) deficiency. Methods: This was a retrospective case study. Nine patients with adolescence-onset MTHFR deficiency were diagnosed at Peking University First Hospital from January 2016 to December 2022, and followed up for more than 1 year. Their general information, clinical manifestations, laboratory tests, cranial images, MTHFR gene variants, diagnosis, treatment, and outcome were analyzed retrospectively...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38526748/planting-the-seed-for-blood-pressure-control-the-role-of-plant-based-nutrition-in-the-management-of-hypertension
#29
REVIEW
Justin A Charles, Nilofer Khan Habibullah, Saul Bautista, Brenda Davis, Shivam Joshi, Sarah C Hull
PURPOSE OF REVIEW: Hypertension results in significant morbidity, mortality, and healthcare expenditures. Fortunately, it is largely preventable and treatable by implementing dietary interventions, though these remain underutilized. Here, we aim to explore the role of healthy dietary patterns in hypertension management and describe approaches for busy clinicians to address nutrition effectively and efficiently with patients. RECENT FINDINGS: DASH, Mediterranean, vegetarian, and vegan diets that include minimally processed, plant-based foods as core elements have consistently shown positive effects on hypertension...
March 25, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38525594/adolescent-stress-induced-ventral-hippocampus-redox-dysregulation-underlies-behavioral-deficits-and-excitatory-inhibitory-imbalance-related-to-schizophrenia
#30
JOURNAL ARTICLE
Thamyris Santos-Silva, Caio Fábio Baeta Lopes, Doğukan Hazar Ülgen, Danielle A Guimarães, Francisco S Guimarães, Luciane Carla Alberici, Carmen Sandi, Felipe V Gomes
BACKGROUND AND HYPOTHESIS: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during adolescence is the ventral hippocampus (vHip). However, the impact of severe stress on vHip redox states and their functional consequences, including behavioral and electrophysiological changes related to SCZ, are not entirely understood...
March 25, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38525592/udp-glucose-p2y14-receptor-signaling-exacerbates-neuronal-apoptosis-after-subarachnoid-hemorrhage-in-rats
#31
JOURNAL ARTICLE
Hideki Kanamaru, Shiyi Zhu, Siyuan Dong, Yushin Takemoto, Lei Huang, Prativa Sherchan, Hidenori Suzuki, Jiping Tang, John H Zhang
BACKGROUND: Subarachnoid hemorrhage (SAH) is a severe subtype of stroke with poor outcomes. Abnormal glucose metabolism often occurs after SAH, but the strict control of blood glucose levels is not always beneficial. This study aimed to investigate the contribution of uridine diphosphate glucose (UDP-G), an intermediate of glucose/glycogen metabolism, and its receptor P2Y14 (P2Y purinoceptor 14) to SAH pathology and explored the potential targeted treatments in rats. METHODS: A total of 218 Sprague-Dawley male rats were used...
March 25, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38524621/novel-homozygous-mutations-in-aire-leading-to-aps-1-and-potential-mechanisms-based-on-bioinformatics-analysis
#32
JOURNAL ARTICLE
Huiping Wu, Yiqi Mo, Shiwen Yu, Xiaojun Ye, Yili Lu, Chaoban Wang, Xiaoou Shan
BACKGROUND: Autoimmune Poly-endocrine Syndrome Type 1 (APS-1), also known as autoimmune poly-endocrinopathy-candidiasis-ectodermal dystrophy (APECED), is a single-gene hereditary disorder usually characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenocortical insufficiency. This syndrome is very rare in China. METHODS: For our reported patient, we employed clinical and laboratory examinations along with genetic identification...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524543/single-nucleus-rna-and-multiomics-in-situ-pairwise-sequencing-reveals-cellular-heterogeneity-of-the-abnormal-ligamentum-teres-in-patients-with-developmental-dysplasia-of-the-hip
#33
JOURNAL ARTICLE
Zhenhui Zhao, Chuiqin Fan, Shiyou Wang, Haoyu Wang, Hansheng Deng, Shuaidan Zeng, Shengping Tang, Li Li, Zhu Xiong, Xin Qiu
Developmental dysplasia of the hip (DDH) is the most common hip deformity in pediatric orthopedics. One of the common pathological changes in DDH is the thickening and hypertrophy of the ligamentum teres. However, the underlying pathogenic mechanism responsible for these changes remains unclear. This study represents the first time that the heterogeneity of cell subsets in the abnormal ligamentum teres of patients with DDH has been resolved at the single-cell and spatial levels by snRNA-Seq and MiP-Seq. Through gene set enrichment and intercellular communication network analyses, we found that receptor-like cells and ligament stem cells may play an essential role in the pathological changes resulting in ligamentum teres thickening and hypertrophy...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524542/clinical-and-genetic-analysis-of-trichohepatoneurodevelopmental-syndrome-caused-by-a-ccdc47-variant
#34
JOURNAL ARTICLE
Qi Yang, Xunzhao Zhou, Yeying Ling, Qiang Zhang, Shang Yi, Qiuli Chen, Shujie Zhang, Zailong Qin, Jingsi Luo
Trichohepatoneurodevelopmental syndrome is an extremely uncommon autosomal recessive disorder resulting from variants in the CCDC47 gene, which encodes a Ca2+ -binding endoplasmic reticulum (ER) transmembrane protein. To date, only four patients with CCDC47 deficiency have been reported, all of them with homozygous truncating CCDC47 variants. For this study, a Chinese family was recruited, which included a patient diagnosed with trichohepatoneurodevelopmental syndrome. Whole exome sequencing (WES) identified the proband's novel homozygous CCDC47 variation (NM_020198: c...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524524/misdiagnosis-of-synovial-sarcoma-cellular-myofibroma-with-srf-rela-gene-fusion-a-case-report
#35
Ying Zhou, Yi-Wen Sun, Xiao-Yang Liu, Dan-Hua Shen
BACKGROUND: Cellular myofibroma is a rare subtype of myofibroma that was first described in 2017. Its diagnosis is often challenging because of its relative rarity, lack of known genetic abnormalities, and expression of muscle markers that can be confused with sarcomas that have myogenic differentiation. Currently, scholars have limited knowledge of this disease, and published cases are few. Further accumulation of diagnostic and treatment experiences is required. CASE SUMMARY: A 16-year-old girl experienced left upper limb swelling for 3 years...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38523604/longitudinal-trajectories-of-cognitive-decline-and-cerebral-blood-flow-abnormalities-in-octogenarian-men-with-normal-global-cognition
#36
JOURNAL ARTICLE
Arkadiusz Siennicki-Lantz, Lena André-Petersson, Sölve Elmståhl
AIMS: Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores>24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF). METHODS: 103 men at age 81 with MMSE scores >24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with the same cognitive test battery at age 68 and age 81: Synonyms (SRB-1), Block design (SRB-3), Paired Associates, Digit Symbol Substitution and Benton Visual Retention test...
2024: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/38522851/-dietary-management-of-obesity
#37
REVIEW
Sang Hoon Lee, San Ha Kim, Sung Chul Park
Obesity is defined as a condition characterized by the abnormal accumulation of fat cells, which results in increased body weight. Worldwide, obesity is progressively on the rise, leading to an increased prevalence of chronic conditions such as cardiovascular disease, type 2 diabetes, and hyperlipidemia. Obesity is a result of the interplay between genetic, metabolic, social, behavioral, and cultural factors, necessitating an interdisciplinary and multimodal management approach. Diet therapy, which includes dietary modifications and nutritional interventions, is a fundamental component of the multifaceted approach to managing obesity...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38522809/skeletal-abnormalities-in-mice-with-dnmt3a-missense-mutations
#38
JOURNAL ARTICLE
Austin Bell-Hensley, Diana C Beard, Kathryn Feeney, Hongjun Zheng, Yunhao Jiang, Xiyun Zhang, Jin Liu, Harrison Gabel, Audrey McAlinden
Overgrowth and intellectual disability disorders in humans are typified by length/height and/or head circumference ≥ 2 standard deviations above the mean as well as intellectual disability and behavioral comorbidities, including autism and anxiety. Tatton-Brown-Rahman Syndrome is one type of overgrowth and intellectual disability disorder caused by heterozygous missense mutations in the DNA methyltransferase 3A (DNMT3A) gene. Numerous DNMT3A mutations have been identified in Tatton-Brown-Rahman Syndrome patients and may be associated with varying phenotype severities of clinical presentation...
March 22, 2024: Bone
https://read.qxmd.com/read/38521138/large-scale-network-abnormality-in-behavioral-addiction
#39
JOURNAL ARTICLE
Pan Chen, Junjing Wang, Guixian Tang, Guanmao Chen, Shu Xiao, Zixuan Guo, Zhangzhang Qi, Jurong Wang, Ying Wang
BACKGROUND: Researchers have endeavored to ascertain the network dysfunction associated with behavioral addiction (BA) through the utilization of resting-state functional connectivity (rsFC). Nevertheless, the identification of aberrant patterns within large-scale networks pertaining to BA has proven to be challenging. METHODS: Whole-brain seed-based rsFC studies comparing subjects with BA and healthy controls (HC) were collected from multiple databases. Multilevel kernel density analysis was employed to ascertain brain networks in which BA was linked to hyper-connectivity or hypo-connectivity with each prior network...
March 21, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38521039/exposure-to-flutolanil-at-environmentally-relevant-concentrations-can-induce-image-and-non-image-forming-failure-of-zebrafish-larvae-through-neuro-and-visual-disruptions
#40
JOURNAL ARTICLE
Yang Yang, Bin He, Xiyan Mu, Suzhen Qi
Numerous pesticides pose a threat to aquatic ecosystems, jeopardizing aquatic animal species and impacting human health. While the contamination of aquatic environment by flutolanil and its adverse effects on animal in the treatment of rich sheath blight have been reported, the neuro-visual effects of flutolanil at environmentally relevant concentrations remain unknown. In this study, we administered flutolanil to zebrafish embryos (0, 0.125, 0.50 and 2.0 mg/L) for 4 days to investigate its impact on the neuro and visual system...
March 21, 2024: Journal of Hazardous Materials
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