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A J Krentz, K Fujioka, M Hompesch
Pharmacotherapy directed toward reducing body weight may provide benefits for both curbing obesity and lowering the risk of obesity-associated comorbidities; however, many weight loss medications have been withdrawn from the market because of serious adverse effects. Examples include pulmonary hypertension (aminorex), cardiovascular toxicity, e.g. flenfluramine-induced valvopathy, stroke [phenylpropanolamine (PPA)], excess non-fatal cardiovascular events (sibutramine), and neuro-psychiatric issues (rimonabant; approved in Europe, but not in the USA)...
June 2016: Diabetes, Obesity & Metabolism
Carlo de Oliveira Martins, Keity Souza Santos, Frederico Moraes Ferreira, Priscila Camillo Teixeira, Pablo Maria Alberto Pomerantzeff, Carlos Ma Brandão, Roney Orismar Sampaio, Guilherme S Spina, Jorge Kalil, Luiza Guilherme, Edecio Cunha-Neto
Rheumatic heart disease (RHD) affects heart-valve tissue and is the most serious consequence of group A Streptococcus infection. Myxomatous degeneration (MXD) is the most frequent valvopathy in the western world. In the present work, key protein expression alterations in the heart-valve tissue of RHD and MXD patients were identified and characterized, with controls from cadaveric organ donors. Proteins were separated by two-dimensional (2D)-electrophoresis and identified by mass spectrometry. We found 17 differentially expressed protein spots, as compared to control samples...
2014: Clinical Medicine Insights. Cardiology
Edmilson Bastos de Moura, Mariana Ribeiro Gomes, Ricardo Barros Corso, Cristiano Nicolleti Faber, Fabiana Pirani Carneiro, Yolanda Galindo Pacheco
BACKGROUND: Cardiopathies are high prevalence conditions. Among them, rheumatic carditis is of high relevance in developing countries. Left cardiac chamber changes are associated to endothelial dysfunction and ET-1 levels increase. Pulmonary circulation is then affected, and not seldom leading to pulmonary hypertension (PH). However, the presence of ET-1 and its receptors in the mitral valve itself--promoting pulmonary vascular changes, with increased rheumatic valvular deformation--has not been discussed in the literature...
July 2010: Arquivos Brasileiros de Cardiologia
Silvio Henrique Barberato, Sérgio G E Bucharles, Admar M Sousa, Costantino O Costantini, Costantino R F Costantini, Roberto Pecoits-Filho
BACKGROUND: Diastolic dysfunction (DD) is frequent in patients on hemodialysis (HD), but its impact on the clinical evolution is yet to be established. OBJECTIVE: To evaluate the prevalence and prognostic impact of left ventricular (LV) advanced diastolic dysfunction (ADD) in patients on hemodialysis. METHODS: The echocardiograms were performed during the first year of HD therapy, in patients with sinus rhythm, with no evidence of cardiovascular disease, excluding those with significant valvopathy or pericardial effusion...
April 2010: Arquivos Brasileiros de Cardiologia
Robinson Poffo, Renato Bastos Pope, Rafael Armínio Selbach, Cláudio Alexandre Mokross, Fabiane Fukuti, Iosmar da Silva Júnior, Andréia Agapito, Isaias Cidral
OBJECTIVE: To demonstrate the possibilities of the use of videothoracoscopy in cardiac surgery using cardiopulmonary bypass (CPB). METHODS: Between February 2006 and November 2008, 102 patients underwent consecutively minimally invasive video-assisted cardiac surgery. The cardiac pathologies approached were: mitral valvopathy (n=56), aortic (n=14), interatrial communication (IC) (n=32), six patients presented associated tricuspid insufficiency and 12 presented atrial fibrillation...
July 2009: Revista Brasileira de Cirurgia Cardiovascular
Roney Orismar Sampaio, Vívian Masutti Jonke, João L Falcão, Sandra Falcão, Guilherme S Spina, Flávio Tarasoutchi, Max Grinberg
BACKGROUND: Coronary angiography has been indicated in the preoperative phase for patients with valvopathy over 35 years of age. However, the actual prevalence of obstructive coronary artery disease (CAD) in this population has been little studied. OBJECTIVE: To assess the prevalence of and the risk factors for CAD in candidates for valve surgery in Brazil. METHODS: Coronary angiography was performed in 3,736 patients who were candidates for valve surgery; prevalence of and risk factors for CAD associated with valvopathy were assessed...
September 2008: Arquivos Brasileiros de Cardiologia
André De Marco, Audes Magalhães Feitosa, Marco Mota Gomes, Giordano Bruno Parente, Edgar Guimarães Victor
OBJECTIVE: Measure the systolic (SP), diastolic (DP) and pulse pressure (PP) using home blood pressure monitoring (HBPM) and correlate its values with the left ventricular mass index (LVMI). METHODS: In 2004, 127 individuals underwent HBPM in a private clinic. A total of 83 of these also underwent an echocardiographic study in a period shorter than 6 months. After excluding those with dilated or ischaemic cardiomyopathy and those with mitral or aortic valvopathies, 72 patients were evaluated for the correlation between SP, DP and PP (SP minus DP) and the LVMI...
January 2007: Arquivos Brasileiros de Cardiologia
Cristina Bueno Terzi, Silvia G Lage, Desanka Dragosavac, Renato G G Terzi
OBJECTIVE: To assess the applicability of three prognostic indexes--APACHE II, SAPS II and UNICAMP II--in a subgroup of critical heart failure (HF) patients. METHODS: Ninety patients were studied, being 12 females and 78 males. Mean age was 56 (18-83). Patients were ranked in functional class IV (NYHA) or cardiogenic shock secondary to cardiomyopathies: dilated (44%), chagasic (25.5%), ischemic (18%), hypertensive (1.1%), hypertrophic (1.1%), alcoholic (1.1%), and secondary to valvopathies after surgical correction (7...
September 2006: Arquivos Brasileiros de Cardiologia
Gurbir S Bhatia, Michael D Sosin, Karl A Grindulis, Russell C Davis, Gregory Y H Lip
Rheumatoid disease (RD) is a common chronic inflammatory condition associated with progressive joint destruction. Sufferers of RD experience reduced life expectancy, reflected in the increased standardised mortality rates reported in several studies over the last 50 years. Most studies indicate that the increased mortality affecting this population is mainly due to cardio-vascular disease. Epidemiological data have revealed an increased risk of developing ischaemic heart disease and heart failure in RD. The increased risk of ischaemic heart disease may result from traditional risk factors but data suggest that RD may confer risk independently...
January 2005: Expert Opinion on Investigational Drugs
R A de Oliveira, de Moraes Silva, R R de Andrade, M R Montenegro
OBJECTIVE: To evaluated the clinical diagnostic, efficiency for basic death causes in patients dying of circulatory disease and de relative frequency of those diseases. METHODS: Analysis of medical record data of 82 patients, ages from 16 to 84 years old (68 over 40 years old), whose died of circulatory disease and had undergone necropsy in the period from 1988 to 1993 years in the University Hospital of Medicine Faculty of Botucatu-UNESP, Br. RESULTS: The functional class of patients were III or IV, in 78%, and 81...
October 2000: Arquivos Brasileiros de Cardiologia
J R Cordeiro, R A Franken, L E Ferlante, G P Camarano, M T Manziolli, L A Rivetti
PURPOSE: To determine, by means of transesophageal echocardiography (TEE), the risk factors for intracavitary thrombosis or prethrombotic state and for embolic accidents in patients with atrial fibrillation. METHODS: We studied 49 patients with chronic atrial fibrillation, submitted to clinical examination, EKG, chest X-ray, and TEE. RESULTS: Thirty percent of patients had valvopathies, 29% myocardiopathies, intracavitary thrombus or prethrombotic state were found in 37%, 40% of them had embolic accidents...
January 1995: Arquivos Brasileiros de Cardiologia
F Tarasoutchi, M Grinberg, J Parga Filho, L F Cardoso, M Izaki, P Lavítola, R H Cardoso, P L da Luz, G Bellotti
PURPOSE: To study the relationship between symptoms and left ventricular function in 68 patients with severe chronic aortic regurgitation using echocardiogram and radionuclide left ventriculography at rest. METHODS: Three stages of natural history are assumed: the 1st, at the beginning of the study, when all patients were asymptomatic (clinical stage 0); the 2nd, at the end of 36 month persistence of asymptomatic (clinical stage 1), consisting of 45 patients (group AA); the 3rd, on occasion of manifestation of the symptoms during this period of time (clinical stage 2), consisting of 21 patients (group AS-PRE), with two fatalities not related to valvopathy...
April 1995: Arquivos Brasileiros de Cardiologia
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