Carlo de Oliveira Martins, Keity Souza Santos, Frederico Moraes Ferreira, Priscila Camillo Teixeira, Pablo Maria Alberto Pomerantzeff, Carlos Ma Brandão, Roney Orismar Sampaio, Guilherme S Spina, Jorge Kalil, Luiza Guilherme, Edecio Cunha-Neto
Rheumatic heart disease (RHD) affects heart-valve tissue and is the most serious consequence of group A Streptococcus infection. Myxomatous degeneration (MXD) is the most frequent valvopathy in the western world. In the present work, key protein expression alterations in the heart-valve tissue of RHD and MXD patients were identified and characterized, with controls from cadaveric organ donors. Proteins were separated by two-dimensional (2D)-electrophoresis and identified by mass spectrometry. We found 17 differentially expressed protein spots, as compared to control samples...
2014: Clinical Medicine Insights. Cardiology