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Thyroid AND reproduction

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https://www.readbyqxmd.com/read/29783245/-epidemiological-features-of-parasitary-invasis-in-women-of-reproductive-age-with-disorders-of-reproductive-health
#1
Valentyna О Sklyarova
OBJECTIVE: The aim: The purpose of this study is to analyze the frequency and structure of parasitic lesion in women with reproductive health disorders. PATIENTS AND METHODS: Materials and methods: The immune-enzyme method tested immunoglobulins IgG to ascaris, lamblia, toxocara. Determination of the presence of pinworm eggs (sticky tape and perianal scrape method) and ascarid (methods of K.Cato, F.Fueleborna and E.S.Schulman). RESULTS: Results: In women with complicated obstetric anamnesis, parasitic invasions occurred in (52...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29767691/thyroid-hormones-and-female-reproduction
#2
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
Thyroid hormones are vital for the proper functioning of the female reproductive system, since they modulate the metabolism and development of ovarian, uterine and placental tissues. Therefore, hypo- and hyperthyroidism may result in subfertility or infertility in both women and animals. Other well-documented sequelae of maternal thyroid dysfunctions include menstrual/estral irregularity, anovulation, abortion, preterm delivery, preeclampsia, intrauterine growth restriction, postpartum thyroiditis, and mental retardation in children...
May 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29765437/evaluation-of-ovarian-reserve-in-women-with-overt-or-subclinical-hypothyroidism
#3
Ferit Kerim Kucukler, Umit Gorkem, Yasin Simsek, Ramazan Kocabas, Serdar Guler
Introduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. In the present study, we sought to evaluate the ovarian reserves of women with autoimmune thyroid disorder by measurement of AMH values. Material and methods: This prospective study included women with newly diagnosed AITD aged between 20 and 40 years...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764939/the-importance-of-a-halotyrosine-dehalogenase-for-drosophila-fertility
#4
Abhishek Phatarphekar, Qi Su, Suk Ho Eun, Xin Chen, Steven E Rokita
The ability of iodotyrosine deiodinase to salvage iodide from iodotyrosine has long been recognized as critical for iodide homeostasis and proper thyroid function in vertebrates. The significance of its additional ability to dehalogenate bromo- and chlorotyrosine is less apparent and none of these functions could have been anticipated in invertebrates until recently. Drosophila , as most arthropods, contains a deiodinase homolog encoded by CG6279 , now named condet ( cdt ), with a similar catalytic specificity...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29764793/evaluation-of-the-ovarian-reserve-in-adolescents-with-hashimoto-s-thyroiditis-using-serum-anti-m%C3%A3-llerian-hormone-levels
#5
Ezgi Özalp Akın, Zehra Aycan
OBJECTIVE: This study aims to evaluate the ovarian reserve of the adolescent girls with Hashimoto's thyroiditis (HT) with serum anti-müllerian hormone (AMH) levels and compare to healthy adolescents. It is hypothesized that HT decreases ovarian reserve and AMH levels are lower in the HT group. METHOD: Thirty HT patients aged between 10-18 years and 30 healthy girls as the control group are enrolled in this cross-sectional study. The mean serum AMH levels of the groups are compared using the Mann-Whitney U test...
May 16, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29742817/effects-of-thyroid-dysfunction-on-reproductive-hormones-in-female-rats
#6
Juan Liu, Meng Guo, Xusong Hu, Xuechun Weng, Ye Tian, Kaili Xu, Dai Heng, Wenbo Liu, Yu Ding, Yanzhou Yang, Cheng Zhang
Thyroid hormones (THs) play a critical role in the development of ovarian cells. Although the effects of THs on female reproduction are of great interest, the mechanism remains unclear. We investigated the effects of TH dysregulation on reproductive hormones in rats. Propylthiouracil (PTU) and L-thyroxine were administered to rats to induce hypo- and hyper-thyroidism, respectively, and the reproductive hormone profiles were analyzed by radioimmunoassay. Ovarian histology was evaluated with H&E staining, and gene protein level or mRNA content was analyzed by western blotting or RT-PCR...
May 10, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29733477/influence-of-organic-phosphorus-on-reproductive-performance-and-metabolic-profiles-of-anoestrous-farafra-ewes-in-subtropics-at-the-end-of-breeding-season
#7
W Senosy, A Y Kassab, H A Hamdon, A A Mohammed
The effect of organic phosphorus on metabolic, haematological and hormonal status, restoration of ovarian functions and conception rate in anoestrous Farafra ewes in subtropics were evaluated. Anoestrous Farafra ewes (n = 24; 34.72 ± 0.52 kg body weight) were allocated into two equal groups: control and phosphorus groups. The ewes of phosphorus group were treated with sodium 4-dimethylamino-2-methyl-phenyl-phosphonate as an organic bound phosphorous twice a week for successive 3 weeks. Ovarian follicle development and corpora lutea were checked three times a week till occurrence of oestrus using ultrasonography while pregnancy was confirmed at 30 days post-service...
May 7, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29729334/the-urgency-for-optimization-and-harmonization-of-thyroid-hormone-analyses-and-their-interpretation-in-developmental-and-reproductive-toxicology-studies
#8
REVIEW
Manon Beekhuijzen, Steffen Schneider, Narinder Barraclough, Nina Hallmark, Alan Hoberman, Sheri Lordi, Mary Moxon, Deborah Perks, Aldert H Piersma, Susan L Makris
In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity...
May 2, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29707880/risk-factors-for-adverse-maternal-and-perinatal-outcomes-in-women-with-preeclampsia-analysis-of-1396-cases
#9
Xun Li, Weishe Zhang, Jianhua Lin, Huai Liu, Zujing Yang, Yincheng Teng, Si Duan, Xinxiu Lin, Yingming Xie, Yuanqiu Li, Liangqun Xie, Qiaozhen Peng, Lu Xia
Preeclampsia is a major cause of adverse maternal and perinatal outcomes, but how to identify women and fetuses at increased risk for later adverse events is a challenge. This study aimed to investigate the risk factors for adverse maternal and perinatal outcomes in women with preeclampsia. Data from 1396 women with preeclampsia were retrospectively collected and analyzed. Eighteen candidate risk factors and 12 adverse outcomes were investigated. The following factors were found to be significantly associated with at least one adverse outcome: maternal age 35 years or older, multiple birth, the usage of assisted reproductive technology, living in a rural area, history of pregnancy-induced hypertension, male fetus, multigravida, or having polycystic ovary syndrome, hemolysis, elevated liver enzymes, and low platelet count syndrome, intrahepatic cholestasis of pregnancy, cardiovascular disease, gestational diabetes mellitus, systemic lupus erythematosus, thyroid disease, or liver disease...
April 30, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29704806/thyroid-function-phthalate-exposure-and-semen-quality-exploring-associations-and-mediation-effects-in-reproductive-aged-men
#10
Yi-Xin Wang, Bin Zhou, Ying-Jun Chen, Chong Liu, Li-Li Huang, Jia-Qiang Liao, Xi-Jiang Hu, Wen-Qing Lu, Qiang Zeng, An Pan
BACKGROUND: A normal thyroid physiology is crucial for the maintenance of male reproductive health. Changes in thyroid hormones may represent an intermediate biological mechanism linking phthalate exposure and potential adverse health effects on male reproduction. OBJECTIVE: To investigate the mediating role of thyroid function on the association between phthalate exposure and semen quality. METHOD: Serum thyroid hormones, semen quality and repeated measures of urinary phthalate metabolites were determined among 509 reproductive-aged men in Wuhan, China...
April 25, 2018: Environment International
https://www.readbyqxmd.com/read/29684825/exposure-to-polybrominated-diphenyl-ethers-and-phthalates-in-healthy-men-living-in-the-greater-montreal-area-a-study-of-hormonal-balance-and-semen-quality
#11
Océane Albert, Jonathan Y Huang, Katarina Aleksa, Barbara F Hales, Cynthia G Goodyer, Bernard Robaire, Jonathan Chevrier, Peter Chan
Studies investigating the associations between exposure of young men to polybrominated diphenyl ethers (PBDEs) or phthalates and hormone levels or semen quality have produced inconsistent results. Our goal was to investigate the association of exposure to PBDEs or phthalate metabolites with changes in markers of thyroid (TSH, free T3 and free T4) and reproductive function (sperm concentrations, motility, and quality; serum LH and testosterone) in 153 healthy young men from the greater Montreal area. Using covariate-adjusted models, we found that each 10-fold increase in BDE-47 was associated with lower TSH levels (-17...
April 20, 2018: Environment International
https://www.readbyqxmd.com/read/29682594/the-role-of-leptin-in-maintaining-plasma-glucose-during-starvation
#12
Rachel J Perry, Gerald I Shulman
For 20 years it has been known that concentrations of leptin, a hormone produced by the white adipose tissue (WAT) largely in proportion to body fat, drops precipitously with starvation, particularly in lean humans and animals. The role of leptin to suppress the thyroid and reproductive axes during a prolonged fast has been well defined; however, the impact of leptin on metabolic regulation has been incompletely understood. However emerging evidence suggests that, in starvation, hypoleptinemia increases activity of the hypothalamic-pituitary-adrenal axis, promoting WAT lipolysis, increasing hepatic acetyl-CoA concentrations, and maintaining euglycemia...
March 2018: Postdoc Journal
https://www.readbyqxmd.com/read/29681207/effect-of-in-utero-and-lactational-exposure-of-triazophos-on-reproductive-system-functions-in-male-offsprings-rattus-norvegicus
#13
Reetu Bhanot, Gurinder Kaur Sangha
In the present study, Triazophos (TZ) was used at acceptable daily intake (ADI) to investigate the consequence of prenatal and postnatal exposure on reproductive functions in the male offsprings. Pregnant females were divided into three groups, the first group was orally gavaged with olive oil (control), the second group was administered with 0.01 mg kg-1 bw of the ADI of TZ from gestation day (GD) 1 until parturition (designated as P group) and the third group was gavaged with the same dose from GD1 to postnatal day (PND) 21 of lactation (marked as P + L group)...
April 23, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29678725/cloning-and-characterization-of-a-second-lamprey-pituitary-glycoprotein-hormone-thyrostimulin-gpa2-gpb5
#14
Krist N Hausken, Belen Tizo, Michal Shpilman, Shannon Barton, Wayne Decatur, David Plachetzki, Scott Kavanaugh, Sabah Ul-Hasan, Berta Levavi-Sivan, Stacia A Sower
A novel heterodimeric glycoprotein hormone (GpH) comprised of alpha (GpA2) and beta (GpB5) subunits was discovered in 2002 and called thyrostimulin for its ability to activate the TSH receptor in mammals, but its central function in vertebrates has not been firmly established. We report here the cloning and expression of lamprey (l)GpB5, and its ability to heterodimerize with lGpA2 to form a functional l-thyrostimulin. The full-length cDNA of lGpB5 encodes 174 amino acids with ten conserved cysteine residues and one glycosylation site that is conserved with other vertebrate GpB5 sequences...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29678724/thyroid-hormone-actions-on-male-reproductive-system-of-teleost-fish
#15
REVIEW
Aldo Tovo-Neto, Maira da Silva Rodrigues, Hamid R Habibi, Rafael Henrique Nóbrega
Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29674245/effects-of-multiple-life-stage-exposure-to-the-fungicide-prochloraz-in-xenopus-laevis-manifestations-of-antiandrogenic-and-other-modes-of-toxicity
#16
Jonathan T Haselman, Patricia A Kosian, Joseph J Korte, Allen W Olmstead, Sigmund J Degitz
The Larval Amphibian Growth and Development Assay (LAGDA) is an internationally harmonized testing guideline for evaluating effects of chronic chemical exposure in amphibians. In order to evaluate the effects of chronic exposure to an antiandrogenic chemical in an amphibian model, prochloraz was tested using a variation of the LAGDA design. Exposure was initiated with <1d post-fertilization embryos at nominal concentrations of 0, 6.7, 20, 60 and 180 μg/L (0, 18, 53, 159, 478 nM) and continued in flow-through conditions until two months following the median time that controls completed metamorphosis...
April 3, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29659964/universal-salt-iodization-provides-sufficient-dietary-iodine-to-achieve-adequate-iodine-nutrition-during-the-first-1000-days-a-cross-sectional-multicenter-study
#17
Susanne Dold, Michael B Zimmermann, Tomislav Jukic, Zvonko Kusic, Qingzhen Jia, Zhongna Sang, Antonio Quirino, Teofilo O L San Luis, Ralph Fingerhut, Roland Kupka, Arnold Timmer, Greg S Garrett, Maria Andersson
Background: Dietary iodine requirements are high during pregnancy, lactation, and infancy, making women and infants vulnerable to iodine deficiency. Universal salt iodization (USI) has been remarkably successful for preventing iodine deficiency in the general population, but it is uncertain if USI provides adequate iodine intakes during the first 1000 d. Objective: We set out to assess if USI provides sufficient dietary iodine to meet the iodine requirements and achieve adequate iodine nutrition in all vulnerable population groups...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658805/subclinical-hypothyroidism-is-not-a-risk-factor-for-polycystic-ovary-syndrome-in-obese-women-of-reproductive-age
#18
Bingjie Zhang, Jing Wang, Shanmei Shen, Jiayi Liu, Jie Sun, Tianwei Gu, Dalong Zhu, Yan Bi
Obese women are at high risk for polycystic ovary syndrome (PCOS). Subclinical hypothyroidism (SCH) has been associated with weight gain, insulin resistance and impaired fertility, which are also factors involved in PCOS. However, there is limited information regarding the influence of SCH on the presence of PCOS. In order to determine whether SCH increases the prevalence of PCOS, we performed a cross-sectional study in a cohort of reproductive-aged obese women. All subjects underwent anthropometric evaluation, laboratory tests and ultrasound examination...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29627605/evaluation-of-bisphenol-a-influence-on-endocannabinoid-system-in-pregnant-women
#19
Monika Zbucka-Kretowska, Robert Zbucki, Ewa Parfieniuk, Maciej Maslyk, Urszula Lazarek, Wojciech Miltyk, Jan Czerniecki, Slawomir Wolczynski, Adam Kretowski, Michal Ciborowski
Bisphenol A (BPA) is a synthetic chemical widely used in the industry, which may potentially evoke negative effects on human health, especially on reproductive processes and fetal development. BPA has been reported to act on estrogen, estrogen-related, androgen, thyroid hormone, pregnane X, peroxisome proliferation-activated, and aryl hydrocarbon receptors. However, other potential mechanisms of BPA action on pregnancy cannot be excluded. Comprehensive evaluation of BPA effect on pregnant women can be performed by use of metabolomics...
March 30, 2018: Chemosphere
https://www.readbyqxmd.com/read/29620956/clinical-hormonal-and-metabolic-parameters-in-women-with-subclinical-hypothyroidism-and-polycystic-ovary-syndrome-a-cross-sectional-study
#20
Mohamed A Bedaiwy, Mohamed Y Abdel-Rahman, Justin Tan, Faten F AbdelHafez, Amr O Abdelkareem, Drisana Henry, Sarka Lisonkova, William W Hurd, James H Liu
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women, yet its clinical presentation shares similarities with several other endocrine disorders such as thyroid disease. Hence, the objective of this study was to further evaluate this association by investigating the clinical, hormonal, and metabolic parameters between subclinical hypothyroidism (SCH) and PCOS. METHODS: This is a cross-sectional study conducted in a tertiary care clinic at Cleveland, Ohio, USA...
April 5, 2018: Journal of Women's Health
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