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Liver transplatation

S de la Fuente, M J Citores, I Baños, A Duca, V Cuervas-Mons
BACKGROUND: Liver transplantation (LT) in adult patients is associated with a higher incidence of cardiovascular risk factors (CVRF), chronic kidney disease (CKD), and cardiovascular disease mortality than the general population. Available information about these problems in adult patients with LT from a pediatric age is limited. The aim of this study was to analyze the incidence of CVRF, risk of developing CKD, and risk of 10-year coronary event in adult patients who received LT in childhood...
November 2014: Transplantation Proceedings
Marcus W Wiedmann, Joachim Mössner
Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis and worldwide rising incidence during the last years. Although orthotopic liver transplatation, surgical resection and local destruction (alcohol or acetic acid and thermal ablation) are the only curative approaches, this can be accomplished in a minority of patients, since most of them present with advanced disease. In addition, those patients who have undergone curative treatment experience a high tumor recurrence rate. Non-resectable HCC is associated with a poor prognosis due to wide resistance to chemotherapeutic agents...
July 2011: Current Cancer Drug Targets
Aleksandar R Karamarkovi, Kristina Doklestić, Vladimir R Djukić, Branislav D Stefanović, Dejan V Radenković, Pavle D Gregorić, Nenad D Ivancević, Zeljko D Lausević, Nada M Popović, Djordje D Bajec
The liver is the most commonly injured abdominal organ. Severe hepatic trauma continue to be associated with high mortality. Management of liver injuries has changed significantly over the last two decades. Nonoperative management of hemodynamically stable patients has become the first treatment of choice. In unstable patients immediate control of bleeding is critical. In the management of severe injuries of the liver, particularly for patients who had developed a metabolic insult (hypothermia, coagulopathy, and acidosis), perihepatic packing has emerged as the key to effective damage control (DCS)...
2010: Acta Chirurgica Iugoslavica
Shu-ichi Ikeda
Familial amyloid polyneuropathy (FAP) was long considered to be an incurable disease, but a new therapeutic approach was developed 15 years ago. As the liver produces most of the transthyretin (TTR) in serum, it was assumed that the replacement of a liver expressing an abnormal TTR gene should stop the production of the variant TTR, the serum amyloid precursor in FAP. Until now about 1,500 FAP patients underwent liver transplantation, and the 10-year-survival rate is about 77%. After operation the progression of FAP symptoms certainly stopped, and patients who were in an early stage of the disease and underwent successful operations showed considerable improvement in their quality of life...
November 2009: Rinshō Shinkeigaku, Clinical Neurology
L F Avila, J L Encinas, N Leal, A Guinea, P García Miguel, P Jara, J Murcia, M Gamez, A Guinea, M López Santamaría, J A Tovar
OBJECTIVE: To analyse our results on liver transplantation (LTX) in primitive malignant unresectable liver tumours in children and discussing its controversial indications in order to our experience. METHODS/PATIENTS: We report 12 patients with ages ranging from 6 months to 14 years old. They had hepatoblastoma (11) and fibrolamellar hepatocelullar carcinoma (1) without cirrhosis. LTX was considered as primary treatment in 10 patients (PRETEXT IV or any grade if extension to retrohepatic cava vein, 3 hepatic veins or porta vein were assessed) and as rescue therapy after recurrence (1) or persistence of unresectable macroscopic rests (2)...
October 2007: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Kevin Tan, Paul Morrissey
No abstract text is available yet for this article.
March 2007: Medicine and Health, Rhode Island
Keum-Soon Kim, Ji-Yeon Kang, Ihn-Sook Jeong
PURPOSE: This study was aimed to investigate the health related quality of life and related factors of organ transplant recipients. METHOD: The participants were 188 people who had liver(86), kidney(81), or heart(24) transplanted. Data on the demographic characteristics, transplantation-related characteristics, symptom frequency or discomfort measured by Transplant Symptom Frequency and Symptom Distress Scale by Lough et al(1987), and health related quality of life measured by SF-36(version 2) were collected...
June 2003: Taehan Kanho Hakhoe Chi
J M Kocken, E de Heer, I H Borel Rinkes, M Sinaasappel, O T Terpstra, J A Bruijn
The survival rate of hepatocytes after allogeneic hepatocyte transplatation (HTX) is low, possibly because of formation of intravascular hepatocyte aggregates. The aim of this study was to determine the role of integrins in intravascular aggregation and intraparenchymal survival of transplanted hepatocytes in a fully allogeneic rat model. First, the expression profile of various integrins was determined on both isolated hepatocytes in vitro and on hepatocyte aggregates in recipient livers after intraportal transplantation of allogeneic hepatocytes...
July 1997: Laboratory Investigation; a Journal of Technical Methods and Pathology
V P Shelepov, S Ia Davydova, V S Shapot
In tumor-bearing rats the hematocrit volume was decreased. It is recommended therefore to estimate the content of glucose in blood serum but not in the whole blood. In rats with Zajhdela ascites hepatoma and with solid hepatoma 27 contents of insulin and glucagon in blood and of glycogen in liver were altered. The nature and magnitude of these alterations varied depending on the type of the transplated tumor. The hormonal disbalance appears to be due to loss of receptor sensitivity towards these hormones. In blood serum of healthy and tumor-bearing rats maximal glucose content was observed within 30 min after sugar loading, after which the content of glucose in blood serum was decreased...
January 1980: Voprosy Medit︠s︡inskoĭ Khimii
L Possati, A Faenza
No abstract text is available yet for this article.
July 1971: Bullettino Delle Scienze Mediche
V Nielsen, E Clausen, L Ranek
Liver impairment has been evaluated in a consecutive series of 79 patients with chronic renal failure of whom 23 were treated with hemodialysis alone and 37 with hemodialysis and renal transplantation alone. In half of the chronic hemodialysis patients and half of the patients receiving a renal allograft elevation of serum alanine aminotransferases was observed for a shorter or longer period during the study. In half of these cases from both groups the clinical course, laboratory data and liver histology were consistent with virus hepatitis and four patients died from fulminant hepatic failure...
March 1975: Acta Medica Scandinavica
R Eloy, M Kedinger, J C Garaud, K Haffen, A J Moody, J F Grenier
This preliminary experimental report confirms the previous interest of isolated endocrine islet transplantation. Moreover a new "privileged position" for the islets grafts is proposed and is as uneventful as a liver biopsy. The functional value of this grafting procedure has been assessed on biological and functional criteria. The transplanted islets are easily retrievable and histological and especially immunocytochemical studies demonstrate the morphological behaviour of such islets. Finally the preliminary survival of allogeneic grafts into the liver supports the concept of the role of the liver during enhancement of facilitation and will be the subject of further investigations...
1975: Langenbecks Archiv Für Chirurgie
V G Vinter, D G Agliullina, I N Andreeva
A comparative study was undertaken on the effect of different RNA preparations on the transplatability and growth of Ehrlich carcinoma. The RNA isolated from Ehrlich carcinoma ascites fluid was found to render the specific stimulating action on the transplantability and growth of a homologous tumor, while total RNA from bovine liver, tRNA from rabbit liver and synthetic polyribonucleotides show no stimulating effect. The RNA from Ehrlich carcinoma ascites fluid is formed as a result of its release from intact tumor cells, and it seems to be one of the factors responsible for the interaction between the tumor and the organism...
1978: Voprosy Onkologii
K J McCormick, N K McCormick, J J Trentin
Two transplantable hepatic carcinomas of the hamster contained CELO virus-induced TSTA, confirming the etiological role of this avian adenovirus in the induction of hepatic tumors. Transplantation resistnace could not be induced with oncogenic adenoviruses of human, simian, or canine origin.
September 1975: Proceedings of the Society for Experimental Biology and Medicine
C F Barker, L G Frangipane, W K Silvers
Hyperglycemia induced in animals by beta cell toxins or by pancreatectomy can be reversed by pancreatic islet transplantation. Abnormal carbohydrate metabolism in juvenile onset human diabetics has also been corrected, albeit temporarily because of graft rejection, by pancreatic transplantation. It does not necessarily follow that naturally occurring diabetes in animals or adult onset diabetes in man would respond to similar treatment. Islet transplantation was studied in mice with chemically induced or genetically determined diabetes...
October 1977: Annals of Surgery
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