Waldimir

BACKGROUND: Pneumococcal disease (PD) remains a major health concern globally. In children, pneumococcal conjugate vaccines (PCVs) provide protection against PD from most vaccine serotypes, but non-vaccine serotypes contribute to residual disease. V114 is a 15-valent PCV containing all 13 serotypes in Prevnar 13™ (PCV13) and public health important serotypes 22F and 33F. This phase 3 study evaluated safety and immunogenicity of mixed PCV13/V114 regimens using a 3 + 1 dosing schedule when changing from PCV13 to V114 at doses 2, 3, or 4...

The present study aimed to evaluate the influence of manual torque (10 Ncm) versus clinical torque (30 Ncm), which is recommended by the manufacturer, on the total length of morse cone implant abutments. Twenty specimens were prepared and distributed into two groups: group 1 with ten analogs for morse cone type implant, and group 2 with ten morse type implants, size 4.3 × 15 cm. In each group, the distance between the implant platform to the top of the prosthetic abutment (abutment height) was measured and subjected to a torque of 10 Ncm...

BACKGROUND: Results from a phase III, randomized, double-blind, active comparator-controlled, parallel-group trial evaluating fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting (CINV) found that a single-day, triple-antiemetic fosaprepitant regimen resulted in a significantly higher proportion of patients achieving a complete response (CR; no vomiting or rescue medication use) in the delayed phase (25-120 h after chemotherapy initiation), compared with a 3-day control regimen ( ClinicalTrials...

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic affects people around the world. However, there have been striking differences in the number of infected individuals and deaths in different countries. Particularly, within Central Europe in countries that are similar in ethnicity, age, and medical standards and have performed similar steps of containment, such differences in mortality rates remain inexplicable. We suggest to consider and explore environmental factors to explain these intriguing variations...

Manipulation of implant surface characteristics constitutes a promising strategy for improving cell growth and tissue response on a variety of materials with different surface topographies. Mesenchymal progenitor cells with a capacity to respond to titanium surface stimuli and differentiate into osteoblasts were used to perform comparative tests between two different implant topographies, including their functional interaction with pre-osteoblasts directly seeded onto the implants. Functional analysis of nanostructured implant surfaces was performed by in vitro assay analysis...

This study aimed to compare the cytotoxicity of the Vita AC12, Lava Ultimate, Vita Enamic and InSync indirect restorative materials. Extracts of each material were prepared by incubation for 1, 7 and 40 days, with daily washing. Human gingival fibroblasts were exposed to the extracts, and cell viability was evaluated by sequential assessment of mitochondrial activity (XTT), membrane integrity (NRU) and cell density (CVDE). Extracts of polystyrene beads and latex fragments were used as negative and positive controls, respectively...

PURPOSE: This study measured the maximum angulation between 2 implants allowed by the internal walls of the component in screw-retained multiple prostheses using rotational abutment-type components. MATERIALS AND METHODS: Thirty specimens of 3 different brands (Conexão; Neodent; and SIN), consisting of titanium rotational abutments connected to external hexagon abutment analogs with standard platforms, were divided into 3 groups. The specimens were internally filled with polyester resin, screw retained, torque, and sectioned to assess the space existing between the internal wall of the rotational abutment component, edge, and vertex of the hexagon...

UNLABELLED: STATEMENTS OF PROBLEM: The lack of passivity in implant dentistry may result in failures. Therefore, impression is the first procedure in the fabrication of a passive prosthesis. The aim of this study is to compare the polyvinyl siloxane technique with a resin-splinted transfer copings used for multiple implant abutment impression. METHODS: A master cast was obtained from an edentate ridge. From the master cast, 30 casts were obtained using 3 different impression techniques...

OBJECTIVE: This study evaluated the compressive strength of first maxillary premolars from young and elderly people. BACKGROUND: Findings have revealed that changes happening on dental structure lead to a higher susceptibility of tooth fracture. MATERIALS AND METHODS: Thirty teeth were divided into four groups as follows: G I (n = 7) premolars of elderly patients with fused roots, G II (n = 8) premolars of elderly with separate roots, G III (n = 7) pre-molars of young people with fused roots and G IV (n = 8) premolars of young people with roots separated...

PURPOSE: The aim of this study was to evaluate, clinically and histologically, the tissues formed in human alveolar sockets filled with bovine morphogenetic protein/bovine organic matrix (BOM) and absorbable membrane (AM) immediately after extraction. MATERIALS: Forty-six human alveolar sockets, exhibiting buccal bone defects were selected for this study. Group 1 received no biomaterial to serve as control. Sockets from group 2 were filled with bovine bone morphogenetic protein (bBMP) associated with bOM...

The biologic principle of guided bone regeneration has been successfully used to prevent bone loss in extraction sites. This study comprises 420 cases of alveolar ridge maintenance in preparation for dental implant placements. Nonexpanded polytetrafluoroethylene membranes were positioned over all extraction sites and left intentionally exposed. Lyophilized mineralized bone allografts were used to prevent membrane collapse when buccal bone walls were lost. Membranes were removed at week 4. At the time of implant placements, all sites presented soft tissue compatibility with keratinized gingiva...

Custom-made abutments are popular to correct malpositioned implants, enhance esthetics, and improve function. The implant abutment can be positioned in 6 or 12 different positions depending on the connection design. In addition, the number of positions increases exponentially when >1 abutment is to be placed. This report presents the fabrication and use of a multiple abutment positional guide. This device reduces the chair time for construction of implant-supported prostheses by seating the abutments within their correct locations...

This randomized, blinded study compared, contralaterally, the dimensions of supracrestal gingival tissue (SGT) in healthy human periodontium. Sulcular probing reaching the crestal bone was performed in 100 dental students (400 teeth [first molars and second premolars] and 1,600 sites). Contralateral measurements were statistically analyzed by one-way analysis of variance. SGT measurements ranged from 1.0 to 6.0 mm. Contralateral measurements showed no statistical difference (P = .096). Measurement of SGT contralaterally prior to crown lengthening or restorative procedures may dictate the needed amount of bone removal or tooth preparation into the sulcus...

Periodontal disease may lead to tooth and tissue loss that can result in esthetic problems. Combined periodontal/prosthodontic treatment for patients with advanced periodontal disease is well documented. This clinical report illustrates a method of treatment for advanced tissue loss in an esthetic area using porcelain laminate veneers and a removable gingival prosthesis.

The success rates of implants placed in the posterior region of both jaws are less than the anterior segments. Anatomic features, mastication dynamics, and adequate implant selection are all significant for long-term prognosis in the molar region. This article discusses important aspects in planning the use of dental implants in the areas of first molars.

The successful maintenance of crestal bone surrounding dental implants is imperative for long-term implant success. Crestal bone loss is reportedly related to stress. However, early perforation and partial exposure of the implant's covering device are a focus for plaque accumulation, which, if left untreated, may result in inflammation. The objective of this study was to evaluate the crestal bone levels adjacent to submerged and exposed unloaded dental implants during the initial healing phase. In addition, the microbiota around exposed implants were studied...