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https://www.readbyqxmd.com/read/29054093/the-role-of-pazopanib-on-tumour-angiogenesis-and-in-the-management-of-cancers-a-review
#1
REVIEW
Dinesh Kumar Chellappan, Jestin Chellian, Zhao Yin Ng, Yan Jinn Sim, Chiu Wei Theng, Joyce Ling, Mei Wong, Jia Hui Foo, Goh Jun Yang, Li Yu Hang, Saranyah Nathan, Yogendra Singh, Gaurav Gupta
Pazopanib is a relatively new compound to be introduced into the chemotherapy field. It is thought to have decent anti-angiogenic properties, which gives an additional hope for the treatment of certain types of cancers. A systematic review solely discussing about pazopanib and its anti-angiogenic effect is yet to be published to date, despite several relevant clinical trials being conducted over the recent years. In this review, we aim to investigate the mechanism of pazopanib's anti-angiogenic effect and its effectiveness in treating several cancers...
October 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29054022/a-shape-code-nanoplasmonic-biosensor-for-multiplex-detection-of-alzheimer-s-disease-biomarkers
#2
Hanbi Kim, Jong Uk Lee, Sojin Song, Soohyun Kim, Sang Jun Sim
Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve cells in the brain. The disease is affected by multifactorial pathways and leads to changes in related biomolecular levels as AD progresses. Therefore, AD should be diagnosed with combined detection of several lesions to improve accuracy. Amyloid beta 1-40, 1-42 and τ (tau) protein are milestones in AD pathology and can be used as main screening and diagnostic target markers. Here, we suggest a highly selective biosensor for detection of AD core biomarkers on one platform through distinct localized surface plasmon resonance (LSPR) depending on gold nanoparticles shapes, called a shape-code biosensor...
October 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29053406/super-resolution-nanoscopy-imaging-applied-to-dna-double-strand-breaks
#3
Sofia D'Abrantes, Sarah Gratton, Pamela Reynolds, Verena Kriechbaumer, Joseph McKenna, Stephen Barnard, Dave Clarke, Stanley W Botchway
Genomic deoxyribonucleic acid (DNA) is continuously being damaged by endogenous processes such as metabolism or by exogenous events such as radiation. The specific phosphorylation of histone H2AX on serine residue 139, described as γ-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs). The yield of γ-H2AX (foci) is shown to have some correlation with the dose of radiation or other DSB-causing agents. However, there is some discrepancy in the DNA DSB foci yield among imaging and other methods such as gel electrophoresis...
October 20, 2017: Radiation Research
https://www.readbyqxmd.com/read/29053371/phytoremediation-capabilities-of-spirodela-polyrhiza-salvinia-molesta-and-lemna-sp-in-synthetic-wastewater-a-comparative-study
#4
Yin Sim Ng, Derek Juinn Chieh Chan
Macrophytes have been used to mitigate eutrophication and upgrade effluent quality via their nutrient removal capability. However, the available data are influenced by factors such as microbial activities, weather, and wastewater quality, making comparison between nutrient removal performance of different macrophytes almost impossible. In this study, phytoremediation by Spirodela polyrhiza, Salvinia molesta and Lemna sp. were carried out axenically in synthetic wastewater under controlled condition to precisely evaluate nutrient removal efficiency of NO3(-)-N, PO4(3-), NH3-N, COD and pH in the water sample...
October 20, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29053108/polaron-effect-on-the-bandgap-modulation-in-monolayer-transition-metal-dichalcogenides
#5
Yao Xiao, Zhiqing Li, Zi-Wu Wang
We theoretically study the bandgap modulation in monolayer transition metal dichalcogenides (TMDs) originating from the carrier-optical phonon coupling in the Fr$\ddot{o}$hlich polaron model, in which both of the surface optical phonons modes induced by the polar substrate and the intrinsic longitudinal optical phonons modes have been taken into account. We find that the modulated magnitude of the bandgap is in range of $100\sim 500$ meV by altering different polar substrates and tuning the internal distance between TMDs and polar substrate...
October 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29052961/amphiphilic-small-peptides-for-delivery-of-plasmid-dnas-and-sirnas
#6
Eun-Kyoung Bang, Hanna Cho, Sean S-H Jeon, Na Ly Tran, Dong-Kwon Lim, Wooyoung Hur, Taebo Sim
Although various delivery systems for nucleic acids have been reported, development of an efficient and non-toxic delivery carrier is still a key subject for gene therapy. In order to find new efficient delivery carriers for nucleic acids, we synthesized amphiphilic peptides composed of a guanidino group, an oleyl group, and a cysteine. We prepared both linear and branched types of peptides, and found that the linear peptides were superior to the branched peptides as nucleic acid carriers. Our study also suggested that the intermolecular cysteine disulfides might allow the linear peptides to form the optimal particle sizes with nucleic acids for cellular uptake...
October 20, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29051650/optimization-of-the-antioxidant-polyphenolic-compounds-extraction-of-yellow-passion-fruit-seeds-passiflora-edulis-sims-by-response-surface-methodology
#7
Fernanda Carvalho de Santana, Lucillia Rabelo de Oliveira Torres, Fernanda Branco Shinagawa, Ana Mara de Oliveira E Silva, Luciana Tedesco Yoshime, Illana Louise Pereira de Melo, Paulo Sergio Marcellini, Jorge Mancini-Filho
The conditions for the solid-liquid extraction of the antioxidant polyphenol compounds from yellow passion fruit seeds were optimized by response surface methodology with the following variables as the extraction parameters: extraction time (12.8-147.2 min), ethanol concentration (13-97%), and temperature (16.4-83.6 °C). The polyphenol content and antioxidant capacity, which were assessed by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, oxygen radical absorbance capacity, β-carotene bleaching assay, and ferric reducing antioxidant power assay, were considered dependent variables...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29049553/evaluating-industry-payments-among-dermatology-clinical-practice-guidelines-authors
#8
Jake X Checketts, Matthew Thomas Sims, Matt Vassar
Importance: It is well documented that financial conflicts of interest influence medical research and clinical practice. Prior to the Open Payments provisions of the Affordable Care Act, financial ties became apparent only through self-disclosure. The nature of financial interests has not been studied among physicians who develop dermatology clinical practice guidelines. Objective: To evaluate payments received by physicians who author dermatology clinical practice guidelines, compare disclosure statements for accuracy, determine whether pharmaceutical companies from which the authors received payments manufactured products related to the guidelines, and examine the extent to which the American Academy of Dermatology enforced their Administrative Regulations for guideline development...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29048856/-rapid-determination-of-four-phenolic-environmental-estrogen-residues-in-cooking-oil-by-ultra-performance-liquid-chromatography-high-resolution-mass-spectrometry-coupled-with-solid-phase-extraction
#9
Shengdong Pan, Qian He, Xiaohong Chen, Li Wang, Qiaoli Qiu, Micong Jin
A fast, sensitive and accurate method for the determination of trace bisphenol S (BPS), bisphenol F (BPF), bisphenol A (BPA) and 4-nonylphenol (4-NP) in cooking oil samples was developed by ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) coupled with solid-phase extraction (SPE). Cooking oil samples were extracted by acetonitrile, then the supernatant was purified by SLC SPE cartridges. The chromatographic separation was carried out on a Waters ACQUITY UPLC HSS T3 column (100 mm×2...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048806/-determination-of-hexabromocyclododecanes-in-ambient-air-by-high-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#10
Yan Li, Longxing Wang, Xiuhua Zhu, Yuan Gao, Jiping Chen
A high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) method was developed for the determination of hexabromocyclododecanes (HBCDs) in ambient air samples. The samples were extracted by Soxhlet extractor with hexane, then purified on the composite gel column. At first, the interfering substances were rinsed with 50 mL hexane and 100 mL hexane-dichloromethane (9:1, v/v), then 180 mL hexane -dichloromethane (4:1, v/v) was used to elute the targets. The compounds were separated by gradient elution with acetonitrile-methanol-water as mobile phases on a UF-ODS column (150 mm×2...
October 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048037/pattern-illuminated-fourier-ptychography-microscopy-with-a-pattern-estimation-algorithm
#11
Ruizhi Cao, Tingting Yang, Yue Fang, Cuifang Kuang, Xu Liu
In this paper we proposed a new method that combines random pattern illumination, the pattern-estimation algorithm, and the Fourier ptychography (FP) algorithm to recover a super-resolution image. We shifted one multispot pattern to different positions to capture images, and estimated these illumination patterns using a gradient descent algorithm that shares the same root with blind structured illumination microscopy (SIM). Based on the captured images and estimated patterns, the FP algorithm is then applied to recover a super-resolution image...
August 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047210/environmental-insights-from-high-resolution-sims-sulfur-isotope-analyses-of-sulfides-in-proterozoic-microbialites-with-diverse-mat-textures
#12
M L Gomes, D A Fike, K D Bergmann, C Jones, A H Knoll
In modern microbial mats, hydrogen sulfide shows pronounced sulfur isotope (δ(34) S) variability over small spatial scales (~50‰ over <4 mm), providing information about microbial sulfur cycling within different ecological niches in the mat. In the geological record, the location of pyrite formation, overprinting from mat accretion, and post-depositional alteration also affect both fine-scale δ(34) S patterns and bulk δ(34) Spyrite values. We report μm-scale δ(34) S patterns in Proterozoic samples with well-preserved microbial mat textures...
October 19, 2017: Geobiology
https://www.readbyqxmd.com/read/29046834/application-of-visible-light-photosensitization-to-form-alkyl-radical-derived-thin-films-on-gold
#13
Rashanique D Quarels, Xianglin Zhai, Neepa Kuruppu, Jenny K Hedlund, Ashley A Ellsworth, Amy V Walker, Jayne C Garno, Justin R Ragains
Visible-light irradiation of phthalimide esters in the presence of the photosensitizer [Ru(bpy)3](2+) and the stoichiometric reducing agent benzyl nicotinamide results in the formation of alkyl radicals under mild conditions. This approach to radical generation has proven useful for the synthesis of small organic molecules. Herein, we demonstrate for the first time the visible-light photosensitized deposition of robust alkyl thin films on Au surfaces using phthalimide esters as the alkyl radical precursors...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29046823/functionalization-of-ti-40nb-implant-material-with-strontium-by-reactive-sputtering
#14
Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming, Jürgen Janek
BACKGROUND: Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of specially designed titanium-niobium (Ti-40Nb) implant alloy would provide an advanced implant system that is mechanically adapted to altered bone with the ability to stimulate bone formation...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29045470/structural-and-functional-analysis-of-smo-1-the-sumo-homolog-in-caenorhabditis-elegans
#15
Parag Surana, Chandrakala M Gowda, Vasvi Tripathi, Limor Broday, Ranabir Das
SUMO proteins are important post-translational modifiers involved in multiple cellular pathways in eukaryotes, especially during the different developmental stages in multicellular organisms. The nematode C. elegans is a well known model system for studying metazoan development and has a single SUMO homolog, SMO-1. Interestingly, SMO-1 modification is linked to embryogenesis and development in the nematode. However, high-resolution information about SMO-1 and the mechanism of its conjugation is lacking. In this work, we report the high-resolution three dimensional structure of SMO-1 solved by NMR spectroscopy...
2017: PloS One
https://www.readbyqxmd.com/read/29045422/cluster-analysis-identifies-three-urodynamic-patterns-in-patients-with-orthotopic-neobladder-reconstruction
#16
Kwang Hyun Kim, Hyun Suk Yoon, Wan Song, Hee Jung Choo, Hana Yoon, Woo Sik Chung, Bong Suk Sim, Dong Hyeon Lee
PURPOSE: To classify patients with orthotopic neobladder based on urodynamic parameters using cluster analysis and to characterize the voiding function of each group. MATERIALS AND METHODS: From January 2012 to November 2015, 142 patients with bladder cancer underwent radical cystectomy and Studer neobladder reconstruction at our institute. Of the 142 patients, 103 with complete urodynamic data and information on urinary functional outcomes were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29043860/development-and-in-vitro-in-vivo-evaluation-of-hpmc-chitosan-gel-containing-simvastatin-loaded-self-assembled-nanomicelles-as-a-potent-wound-healing-agent
#17
Jaleh Varshosaz, Somayeh Taymouri, Mohsen Minaiyan, Fatemeh Rastegarnasab, Azar Baradaran
The aim of this study was to develop hydroxypropyl methyl cellulose (HPMC)/chitosan gel containing polymeric micelles loaded with simvastatin (Sim) and evaluates its wound healing properties in rats. An irregular full factorial design was employed to evaluate the effects of various formulation variables including polymer/drug ratio, hydration temperature, hydration time and organic solvent type on the physicochemical characteristics of pluronic F127-cholesterol nanomicelles prepared using the film hydration method...
October 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29043668/preparation-and-imaging-of-specialized-er-using-super-resolution-and-tem-techniques
#18
Karen Bell, Karl Oparka, Kirsten Knox
The plant endoplasmic reticulum (ER) forms several specialized structures. These include the sieve element reticulum (SER) and the desmotubule formed as the ER passes through plasmodesmata. Imaging both of these structures has been inhibited by the resolution limits of light microscopy and their relatively inaccessible locations, combined with the fragile nature of the ER. Here we describe methods to view desmotubules in live cells under 3D-structured illumination microscopy (3D-SIM) and methods to fix and prepare phloem tissue for both 3D-SIM and transmission electron microscopy (TEM) which preserve the fragile structure and allow the detailed imaging of the SER...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29042678/carnosine-scavenging-of-glucolipotoxic-free-radicals-enhances-insulin-secretion-and-glucose-uptake
#19
Michael J Cripps, Katie Hanna, Charlie Lavilla, Sophie R Sayers, Paul W Caton, Craig Sims, Luigi De Girolamo, Craig Sale, Mark D Turner
The worldwide prevalence of diabetes has risen to 8.5% among adults, which represents a staggering rise in prevalence from 4.7% in 1980. Whilst some treatments work by increasing insulin secretion, over time their effectiveness decreases. We aim to increase insulin secretion by developing strategies that work through mechanisms independent of current treatment options. Isolated CD1 mouse islets, INS-1 pancreatic β-cells, or C2C12 mouse myotubes were incubated in standard tissue culture media, or media supplemented with 28 mM glucose, 200 μM palmitic acid, and 200 μM oleic acid as a cellular model of diabetic glucolipotoxicity...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042657/unravelling-the-chemical-influence-of-water-on-the-pmma-aluminum-oxide-hybrid-interface-in-situ
#20
Sven Pletincx, Kristof Marcoen, Lena Trotochaud, Laura-Lynn Fockaert, Johannes M C Mol, Ashley R Head, Osman Karslioğlu, Hendrik Bluhm, Herman Terryn, Tom Hauffman
Understanding the stability of chemical interactions at the polymer/metal oxide interface under humid conditions is vital to understand the long-term durability of hybrid systems. Therefore, the interface of ultrathin PMMA films on native aluminum oxide, deposited by reactive adsorption, was studied. The characterization of the interface of the coated substrates was performed using ambient pressure X-ray photoelectron spectroscopy (APXPS), Fourier transform infrared spectroscopy in the Kretschmann geometry (ATR-FTIR Kretschmann) and time-of-flight secondary ion mass spectrometry (ToF-SIMS)...
October 17, 2017: Scientific Reports
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