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https://www.readbyqxmd.com/read/29232606/microwave-assisted-synthesis-for-a2e-and-development-of-lc-esi-ms-method-for-quantification-of-ocular-bisretinoids-in-human-retina
#1
A Kotnala, S Senthilkumari, N Halder, A Kumar, T Velpandian
PURPOSE: To develop a microwave assisted method for the rapid synthesis of A2E and also to develop a method to quantify N-retinylidene-N-retinylethanolamine(A2E), all-trans retinal dimer (ATRD), A2-glycerophospho ethanolamine (A2GPE), dihydropyridine phosphatidyl ethanolamine (A2DHPE) and monofuran A2E (MFA2E) in age matched retina. METHODS: The development of microwave assisted synthesis of A2E, its purification and characterization for its utility in quantification in human retina...
November 26, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29231287/using-secondments-in-tertiary-health-facilities-to-build-paediatric-expertise-in-allied-health-professionals-working-in-rural-new-south-wales
#2
Carmel Blayden, Sonia Hughes, Jennifer Nicol, Susan Sims, Isobel J Hubbard
OUTLINE OF PROBLEM: Allied health professionals working in rural settings have broad caseloads requiring advanced skills as general specialists. This can include children with specialised needs. DESIGN: Educational secondments were coordinated for allied health professionals to achieve self-nominated learning objectives. Learning objectives were assessed using pre and post evaluations to determine the effect of the educational secondment on knowledge and confidence specific to the nominated learning outcomes...
December 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29230066/functional-and-evolutionary-analysis-of-korean-bob-tailed-native-dog-using-whole-genome-sequencing-data
#3
Daehwan Lee, Dajeong Lim, Daehong Kwon, Juyeon Kim, Jongin Lee, Mikang Sim, Bong-Hwan Choi, Seog-Gyu Choi, Jaebum Kim
Rapid and cost effective production of large-scale genome data through next-generation sequencing has enabled population-level studies of various organisms to identify their genotypic differences and phenotypic consequences. This is also used to study indigenous animals with historical and economical values, although they are less studied than model organisms. The objective of this study was to perform functional and evolutionary analysis of Korean bob-tailed native dog Donggyeong with distinct tail and agility phenotype using whole-genome sequencing data by using population and comparative genomics approaches...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229653/investigation-of-time-to-first-presentation-and-extrahospital-factors-in-the-treatment-of-neovascular-age-related-macular-degeneration-a-retrospective-cross-sectional-study
#4
Peng Yong Sim, Sonul Gajree, Baljean Dhillon, Shyamanga Borooah
OBJECTIVES: To assess the time from symptom onset to treatment for neovascular age-related macular degeneration (nvAMD) and to measure the awareness of AMD in Southeast Scotland. DESIGN: Retrospective cross-sectional study. SETTING: Secondary care, Southeast of Scotland. METHODS: Patients treated with intravitreal therapy (IVT) for nvAMD in Southeast Scotland between 2013 and 2015 were identified using a treatment register...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229562/electromechanical-properties-of-human-osteoarthritic-and-asymptomatic-articular-cartilage-are-sensitive-and-early-detectors-of-degeneration
#5
I Hadjab, S Sim, S S Karhula, S Kauppinen, M Garon, E Quenneville, P Lavigne, P P Lehenkari, S Saarakkala, M D Buschmann
OBJECTIVE: To evaluate cross-correlations of ex vivo electromechanical properties with cartilage and subchondral bone plate thickness, as well as their sensitivity and specificity regarding early cartilage degeneration in human tibial plateau. METHOD: Six pairs of tibial plateaus were assessed ex vivo using an electromechanical probe (Arthro-BST) which measures a quantitative parameter (QP) reflecting articular cartilage compression-induced streaming potentials...
December 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29228710/irisin-treatment-improves-healing-of-dystrophic-skeletal-muscle
#6
Musarrat Maisha Reza, Chu Ming Sim, Nathiya Subramaniyam, Xiaojia Ge, Mridula Sharma, Ravi Kambadur, Craig McFarlane
Background: Irisin is an exercise induced myokine that is shown to promote browning of adipose tissue and hence, increase energy expenditure. Furthermore, our unpublished results indicate that Irisin improves myogenic differentiation and induces skeletal muscle hypertrophy. Since exercise induced skeletal muscle hypertrophy improves muscle strength, we wanted to investigate if ectopic injection of Irisin peptide improves skeletal muscle function in a mouse model of muscular dystrophy...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227466/morbidity-and-mortality-of-a-cohort-of-peruvian-hiv-infected-children-2003-2012
#7
Amira N Baker, Angela M Bayer, Rolando M Viani, Lenka Kolevic, Myung-Shin Sim, Jaime G Deville
BACKGROUND: Data on pediatric HIV in Peru is limited. The National Institute of Child Health (Instituto Nacional de Salud del Niño: INSN) cares for the most HIV-infected children under age 18 in the country. We describe the outcomes of children seen at INSN's HIV clinic over the 10 years when antiretroviral therapy (ART) and prevention of mother-to-child transmission (PMTCT) interventions became available in 2004. METHODS: We conducted a retrospective review of INSN HIV clinic patients between 2003-2012...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29226681/protein-nanotube-selectively-cleavable-with-dna-supramolecular-polymerization-of-dna-appended-molecular-chaperones
#8
Daiki Kashiwagi, Seunghyun Sim, Tatsuya Niwa, Hideki Taguchi, Takuzo Aida
Here we report molecular chaperone GroELs that carry, at their apical domains, multiple DNA strands (ideally 28 DNA strands in total) with defined oligonucleotide (nt) sequences. This design strategy allows for the preparation of GroEL10a and GroEL10b carrying 10-nt DNA strands of 10a and 10b with complementary sequences, respectively, at their apical domains (Table 1). One-dimensional coassembly of these GroELs is possible to form protein nanotube NT10a/10b with an anomalous thermodynamic stability due to the exceptionally large multivalency for the coassembly...
December 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29225301/paralysis-of-the-rectus-abdominis-muscle-after-a-video-assisted-thoracoscopic-surgery
#9
Hyun Min Cho, Hee Je Sim, Do Hyung Kim, Mi Hee Lim, Sang Kwon Lee
The rectus abdominis muscle is innervated by intercostal nerves T7-T12, and most thoracotomies are performed through the fourth to sixth intercostal spaces, so direct nerve damage to the rectus abdominis seems unlikely. However, at least one trocar is inserted below the seventh intercostal space in most multi-port video-assisted thoracoscopic surgeries (VATSs), and injury of the seventh or lower intercostal nerve with related paralysis of the rectus abdominis is possible, albeit rare. Only two cases of rectus abdominis paralysis caused by after VATSs have been reported, and these cases were not permanent injuries...
December 8, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29220423/tpeak-tend-interval-during-therapeutic-hypothermia-can-predict-upcoming-ventricular-fibrillation-in-subjects-with-aborted-arrhythmic-sudden-cardiac-death-3-years-follow-up-results
#10
Namsik Yoon, Seo Hong, Aaron Glass, Sung Soo Kim, Min Chul Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Kye Hun Kim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Jeong, Jong Chun Park, Jeong Gwan Cho
Aims: Prolonged Tpeak-Tend interval has been shown to be markers of arrhythmogenesis in various cardiac disorders. However, its dynamicity is one of the obstacles to predict fatal ventricular arrhythmia. This study investigated whether Tpeak-Tend interval during therapeutic hypothermia (TH) is associated with ventricular fibrillation (VF) inducibility and clinical arrhythmia in subjects with aborted arrhythmic sudden cardiac death (SCD). Methods and results: The study group included 31 patients (24 males, age 39...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29220421/optimal-dose-of-dabigatran-for-the-prevention-of-thromboembolism-with-minimal-bleeding-risk-in-korean-patients-with-atrial-fibrillation
#11
Ki Hong Lee, Hyung Wook Park, Nuri Lee, Dae Young Hyun, Jumin Won, Sung Sik Oh, Hyuk Jin Park, Yongcheol Kim, Jae Yeong Cho, Min Chul Kim, Doo Sun Sim, Hyun Joo Yoon, Nam Sik Yoon, Kye Hun Kim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jong Chun Park, Jeong Gwan Cho
Aims: We aim to determine the optimal dose of dabigatran in Korean patients with atrial fibrillation (AF). Methods and results: We analysed 1834 patients with non-valvular AF, classified into a warfarin group (n = 990), dabigatran 150 mg group (D150, n = 294), and 110 mg group (D110, n = 550). The D110 group was further classified into patients concordant (co-D110, n = 367) and patients discordant (di-D110, n = 183) with guidelines to dose reduction...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29219412/nonlocal-entanglement-of-1d-thermal-states-induced-by-fermion-exchange-statistics
#12
YeJe Park, Jeongmin Shim, S-S B Lee, H-S Sim
When two identical fermions exchange their positions, their wave function gains a phase factor of -1. We show that this distance-independent effect can induce nonlocal entanglement in one-dimensional (1D) electron systems having Majorana fermions at the ends. It occurs in the system bulk and has a nontrivial temperature dependence. In a system having a single Majorana fermion at each end, the nonlocal entanglement has a Bell-state form at zero temperature and decays as the temperature increases, vanishing suddenly at a certain finite temperature...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218613/can-we-perform-ct-of-the-appendix-with-less-than-1-msv-a-de-escalating-dose-simulation-study
#13
Ji Hoon Park, Jong-June Jeon, Sung Soo Lee, Amar C Dhanantwari, Ji Ye Sim, Hae Young Kim, Kyoung Ho Lee
OBJECTIVES: To systematically explore the lowest reasonably achievable radiation dose for appendiceal CT using an iterative reconstruction (IR) in young adults. METHODS: We prospectively included 30 patients who underwent 2.0-mSv CT for suspected appendicitis. From the helical projection data, 1.5-, 1.0- and 0.5-mSv CTs were generated using a low-dose simulation tool and the knowledge-based IR. We performed step-wise non-inferiority tests sequentially comparing 2...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29218498/the-epidemiology-of-coping-in-african-american-adults-in-the-jackson-heart-study-jhs
#14
Allison B Brenner, Ana V Diez-Roux, Samson Y Gebreab, Amy J Schulz, Mario Sims
Differences in coping within the African American population are not well understood, yet these differences may be critical to reducing stress, improving health, and reducing racial health disparities. Using a descriptive, exploratory analysis of the Jackson Heart Study (N = 5301), we examine correlations between coping responses and associations between coping and demographic, socioeconomic, psychosocial, and neighborhood factors. Overall, coping responses were not strongly correlated and patterns of associations between covariates and coping responses were largely inconsistent...
December 7, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29216500/strontium-and-bisphosphonate-coated-iron-foam-scaffolds-for-osteoporotic-fracture-defect-healing
#15
Seemun Ray, Ulrich Thormann, Marlen Eichelroth, Matthäus Budak, Christoph Biehl, Markus Rupp, Ursula Sommer, Thaqif El Khassawna, Francisca I Alagboso, Marian Kampschulte, Marcus Rohnke, Anja Henß, Klaus Peppler, Vanessa Linke, Peter Quadbeck, Axel Voigt, Florian Stenger, Daniel Karl, Reinhard Schnettler, Christian Heiss, Katrin S Lips, Volker Alt
The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy and multi-deficient diet for 3 months. A 4 mm wedge shaped metaphyseal osteotomy was created, fixed with a mini-plate and subsequently filled with Fe, FeSr, FeBiP or left empty. After 6 weeks, μCt analysis revealed a statistically significant increased bone formation at the implant interface in FeSr compared to FeBiP (p = 0...
December 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29216182/the-physicochemical-fingerprint-of-necator-americanus
#16
Veeren M Chauhan, David J Scurr, Thomas Christie, Gary Telford, Jonathan W Aylott, David I Pritchard
Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world's population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs (L3) to the intestinal tract (L4 maturing to adult). It has been hypothesised that the L3 larval sheath, which is shed during percutaneous infection (exsheathment), diverts the immune system to allow successful infection and reinfection in endemic areas. However, the physicochemical properties of the L3 larval cuticle and sheath, which are in direct contact with the skin and its immune defences, are unknown...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29215670/is-a-strong-axial-crystal-field-the-only-essential-condition-for-a-large-magnetic-anisotropy-barrier-the-case-of-non-kramers-ho-iii-versus-tb-iii
#17
Sandeep K Gupta, Thayalan Rajeshkumar, Gopalan Rajaraman, Ramaswamy Murugavel
A monometallic non-Kramers Ho(iii) complex with a strong uniaxial ligand field displays a record high energy barrier of 355 K with hysteresis opening up to 4 K at a sweep rate of 0.027 T s-1, while the isomorphous, more anisotropic non-Kramers Tb(iii) complex displays strong quantum tunnelling between the ground states. Ab initio calculations reveal that the presence of strong axial ligands and moderately weaker equatorial ligands is sufficient to quench the QTM between the ground pseudo doublets (mJ = ±8) in the case of Ho(iii) complex, where the relaxation is found to proceed via the first excited state...
December 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29215477/prophylactic-ureteral-catheters-for-colectomy-a-national-surgical-quality-improvement-program-based-analysis
#18
Kathleen M Coakley, Kevin R Kasten, Stephanie M Sims, Tanushree Prasad, B Todd Heniford, Bradley R Davis
BACKGROUND: Despite improvement in technique and technology, using prophylactic ureteral catheters to avoid iatrogenic ureteral injury during colectomy remains controversial. OBJECTIVE: The aim of this study was to evaluate outcomes and costs attributable to prophylactic ureteral catheters with colectomy. DESIGN: This was a retrospective study. SETTINGS: The study was conducted at a single tertiary care center. PATIENTS: The colectomy-targeted American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2014 was queried...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29215351/moringa-oleifera-functionalised-sand-reuse-with-non-ionic-surfactant-dodecyl-glucoside
#19
Frances E Williams, Andrew K Lee, Sanaz Orandi, Sarah K Sims, David M Lewis
Moringa oleifera seeds are well known for their ability to cause flocculation in turbid water and facilitate bacterial inhibition. These effects are due to the cationic polypeptide MO2.1, which affects the surface charge of suspended particles and causes lysis of bacterial cells. However, the attachment of bacteria to MO2.1 prevents further bacterial attachment, reducing the effectiveness of the seeds. This research investigated the effect of surfactants on functionality and reuse of Moringa seeds to develop a sustainable water treatment technique...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29214813/development-implementation-and-evaluation-of-active-lions-a-campaign-to-promote-active-travel-to-a-university-campus
#20
Melissa Bopp, Dangaia Sims, Stephen A Matthews, Liza S Rovniak, Erika Poole, Joanna Colgan
PURPOSE: To outline the development, implementation, and evaluation of a multistrategy intervention to promote active transportation, on a large university campus. DESIGN: Single group pilot study. SETTING: A large university in the Northeastern United States. PARTICIPANTS: University students (n = 563), faculty and staff (employees, n = 999) were included in the study. INTERVENTION: The Active Lions campaign aimed to increase active transportation to campus for all students and employees...
January 1, 2017: American Journal of Health Promotion: AJHP
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