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https://www.readbyqxmd.com/read/29151911/multiple-pulmonary-metastases-with-halo-sign-from-malignant-mixed-m%C3%A3-llerian-tumors
#1
Hong-Wei Tian, Wei-Bing Yang, Meng-Jie Yang, Jing-Yuan Liu, Jian-Chu Zhang, Xiao-Nan Tao, Qiong Zhou
The lungs are one of the most common organs to which cancer metastasizes, but are a location not common for uterine sarcoma. A malignant mixed Müllerian tumor (MMMT) of the uterus is an extremely rare and aggressive sarcoma, characterized by a mixture of epithelial and mesenchymal components. There are few reports regarding the pulmonary metastasis from MMMTs. The present study presents the case of a 58-year-old woman with hemoptysis and post-menopausal vaginal bleeding. The woman was initially diagnosed with invasive aspergillosis based on a chest computed tomography (CT) scan showing multiple pulmonary nodular opacities surrounded by a ground-glass attenuation halo (halo-sign)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29149644/assessing-the-risk-of-laparoscopic-morcellation-of-occult-uterine-sarcomas-during-hysterectomy-and-myomectomy-literature-review-and-the-isge-recommendations
#2
REVIEW
Ornella Sizzi, Lucia Manganaro, Alfonso Rossetti, Matteo Saldari, Giuseppe Florio, Alessandro Loddo, Robert Zurawin, Bruno van Herendael, Dusan Djokovic
OBJECTIVE: This project of the International Society for Gynecologic Endoscopy (ISGE) had the objective to review the literature and provide recommendations on the occult sarcoma risk assessment in patients who are candidates for minimally invasive gynecological surgery involving intra-abdominal electromechanical tissue morcellation. STUDY DESIGN: The ISGE Task Force for Estimation of the Risk in Endoscopic Morcellation initially defined key topics and clinical questions which may guide a comprehensive preoperative patient assessment...
November 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29136690/-values-of-jazf1-gene-rearrangement-detected-by-fluorescence-in-situ-hybridization-in-diagnosis-of-endometrial-stromal-tumours
#3
Q M Bai, B Chang, X Y Tu, R Bi, Y F Cheng, D Huang, X L Zhu, L J Wu, X Zhang, X Y Zhou, W T Yang
Objective: To investigate the role of JAZF1 gene rearrangement in the diagnosis and differential diagnosis of endometrial stromal sarcomas by fluorescence in situ hybridization (FISH). Methods: JAZF1 gene rearrangement was analyzed by FISH in 129 cases of ESS diagnosed from January 2008 to December 2016 including 105 cases of low-grade endometrial stromal sarcoma (LG-ESS), 21 cases of high-grade endometrial stromal sarcoma (HG-ESS) and 3 cases of undifferentiated uterine sarcoma (UUS). Sixteen cases of the related tumours in uterus were also collected as control group...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29133752/proportion-of-uterine-malignant-tumors-in-patients-with-laparoscopic-myomectomy-a-national-multicenter-study-in-china
#4
Hua Yang, Xiao-Chuan Li, Chen Yao, Jing-He Lang, Hang-Mei Jin, Ming-Rong Xi, Gang Wang, Lu-Wen Wang, Min Hao, Yan Ding, Jie Chen, Jian-Qing Zhang, Lu Han, Cheng-Xiu Guo, Xiang Xue, Yan Li, Jian-Hua Zheng, Man-Hua Cui, Huai-Fang Li, Guang-Shi Tao, Long Chen, Su-Min Wang, An-Wei Lu, Ze-Hua Huang, Qing Liu, Ya-Li Zhuang, Xiang-Hua Huang, Gen-Hai Zhu, Ou-Ping Huang, Li-Na Hu, Mu-Jun Li, Hong-Lin Zhou, Jing-Hui Song, Lan Zhu
BACKGROUND: The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. METHODS: A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29128980/reducing-the-spread-of-occult-uterine-sarcoma-at-the-time-of-minimally-invasive-gynecologic-surgery
#5
Marron Wong, Rudy Leon De Wilde, Keith Isaacson
PURPOSE: This review covers the most recent evidence to discuss the incidence of occult uterine sarcoma, whether morcellation increases tumor dissemination or mortality, and whether there is a difference between different types of morcellation. We will also discuss techniques to reduce the spread of an undiagnosed uterine sarcoma. METHOD: A comprehensive literature search was made in Pubmed, Medline, the Cochrane Library, and Google Scholar for articles related to the incidence of occult uterine sarcoma after morcellation...
November 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29126743/benign-and-malignant-pathology-of-the-uterus
#6
REVIEW
V Tanos, K E Berry
The diagnosis of a uterine myoma size and location can be very precise when a 3D sonograph and knowledge are available. The majority of fibroids are asymptomatic, and expectant management is recommended. In young patients, fibroids cause infertility and in middle-aged women, abnormal uterine bleedings. Laparoscopic myomectomy is the preferred way of surgery for IM and SS fibroids, versus hysteroscopy for SM fibroids. In both cases, the size, number of fibroids and the surgeon's experience determine the limitations of the MIGS...
October 16, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29116937/synthesis-and-biological-evaluation-of-acyl-derivatives-of-hydroxyflavones-as-potent-antiproliferative-agents-against-drug-resistance-cell-lines
#7
Monika Stompor, Marta Świtalska, Joanna Wietrzyk
The synthesis of hydroxyflavone derivatives is described. The acyl derivatives of 3-, 6-, 7-hydroxyflavones (compounds 2, 4, 6, respectively) and chrysin (5,7-dihydroxyflavone, 7) were obtained in high yields and evaluated in vitro for their cytotoxic activity against several cancer cell lines of different origin: MCF-7 (breast cancer), A549 (nonsmall cell lung cancer), MES-SA (uterine sarcoma), LoVo (colon cancer), drug-resistant human cancer cells (MES-SA/DX5, LoVo/DX) and also towards non-cancer cell line MCF-10A (normal breast epithelial cells)...
November 8, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29063234/the-growth-of-uterine-myomas-in-untreated-women-influence-factors-and-ultrasound-monitoring
#8
Robert Armbrust, Klaus-Dieter Wernecke, Jalid Sehouli, Matthias David
PURPOSE: Until now there are no systematic studies about the long-term course of myoma growth. Therefore, the aims of the present study were: (1) ultrasound monitoring of the natural course of growth of uterine leiomyomas; (2) assessment of whether the growth of myomas depends on the age of the patients, the location, or the initial size (possible co-factors/predictor criteria for increase of growth); influence of oral contraceptives (OC). METHODS: Patient records (2010-May 2016) were retrospectively and systematically evaluated in regards to their growth and clinical course...
October 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29061369/unsuspected-uterine-sarcoma-in-an-urban-hospital-does-surgical-approach-matter
#9
Marianne N DiNapoli, Mireille D Truong, Johanna K Halfon, William M Burke
STUDY OBJECTIVE: To compare the incidence of unsuspected uterine sarcoma based on surgical approach: open versus minimally invasive approaches for myomectomies and hysterectomies. DESIGN: Retrospective chart review of demographic data, preoperative characteristics, operative details, and pathology results from the electronic medical record. DESIGN: Classification: II-3 SETTING: A large, urban, academic medical center. PATIENTS: All women undergoing myomectomy or hysterectomy performed for benign indications by a benign gynecologic surgery between 2010 and 2014...
October 20, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29040191/incidence-patterns-and-survival-of-gynecological-sarcoma-in-germany-analysis-of-population-based-cancer-registry-data-on-1066-women
#10
Klaus Pietzner, Nina Buttmann-Schweiger, Jalid Sehouli, Klaus Kraywinkel
OBJECTIVE: Sarcomas of the female genital tract are rare tumors. They are described to be associated with a poor prognosis when compared with gynecogical carcinoma. The aim of this study was to report incidence patterns and survival rates for gynecological sarcoma (GS) in Germany. METHODS/MATERIALS: Clinical data and survival rates for patients with GS diagnosed in Germany between 2009 and 2013 were extracted from the German national center for population-based cancer registry data...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29030194/doughnut-shaped-bovine-serum-albumin-nanoparticles-loaded-with-doxorubicin-for-overcoming-multidrug-resistance-in-cancer-cells
#11
Zahra Kayani, Omidreza Firuzi, Abdol-Khalegh Bordbar
Traditional spherical albumin nanoparticles remain the dominant shape of nano-carriers described in the literature at present, due to their simple desolvation method of synthesis. However, non-spherical shapes also show great promise as cancer drug delivery vectors. In this study, we report a novel synthetic strategy based on dimethyl sulfoxide (DMSO) addition during desolvation step, to produce doughnut-shaped bovine serum albumin nanoparticles (DBSA-NPs), while maintaining narrow size distributions and homogeneity...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29020787/-carcinosarcoma-of-the-endometrium-with-melanocytic-differentiation-case-report
#12
D Berezovskiy, P Vlasák, J Kosťun, J Bouda, J Presl
OBJECTIVE: The case report presents a case of 60-year old woman with a rare malignant mixed Müllerian tumor with melanomatous differentiation diagnosed from a histology after cervical polyp ablation and curettage. DESIGN: Case report. SETTING: Department of gynecology and obstetrics, University Hospital in Pilsen. CONCLUSION: Carcinosarcoma, previously malignant mixed Müllerian tumor, is a very rare aggressive endometrial carcinoma with low incidence, which typically occurs among older women and commonly affects the uterine body and cervix...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28982163/oncogenic-hrasg12v-expression-plus-knockdown-of-cdkn2a-using-ecotropic-lentiviral-vectors-induces-high-grade-endometrial-stromal-sarcoma
#13
Laura P Brandt, Joachim Albers, Tomas Hejhal, Antonella Catalano, Peter J Wild, Ian J Frew
The uterine corpus represents the most common site for tumour development in the female genital system. Uterine neoplasms are categorised as epithelial, mesenchymal, mixed epithelial-mesenchymal or trophoblastic tumours. In this study we employed a mouse genetic approach using the MuLE lentiviral gene regulatory system to functionally test the ability of ecotropic lentiviruses to model epithelial and mesenchymal uterine malignancies ex vivo and in vivo. We discovered that MuLE lentiviruses efficiently infect uterine stromal cells but not endometrial epithelial cells when injected into the uterus of cycling, pseudopregnant or ovarectomized mice...
2017: PloS One
https://www.readbyqxmd.com/read/28975775/morcellation-of-occulted-sarcomas-during-laparoscopic-myomectomy-and-hystrectomy-for-patients-with-large-fibroid-uterus
#14
Andrea Tinelli, Samir A Farghaly
In April 2014, the United States of America Food and Drug Administration (FDA) published a safety communication warning of the risk of an unsuspected uterine sarcoma being morcellated during a laparoscopic procedure, and advised against the use of power morcellation. In November of the same year, this agency stated: 1. Laparoscopic power morcellators are contraindicated for removal of uterine tissue containing suspected fibroids in patients who are peri- or post-menopausal, or are candidates for "en bloc" tissue removal...
October 3, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28968994/primary-endometrioid-stromal-sarcomas-of-the-ovary-a-clinicopathological-study-of-14-cases-with-a-review-of-the-literature
#15
Weimin Xie, Xiaoning Bi, Dongyan Cao, Jiaxin Yang, Keng Shen, Yan You
PURPOSE: Primary endometrioid stromal sarcomas (ESS) of the ovary are rare mesenchymal tumors with scarce data on their behavior and optimal treatment. We aimed to describe the clinicopathologic features and outcome among patients with primary ovarian ESS. RESULTS: The age of the patients ranged from 34 to 61 years (mean: 49.1 years, median: 51.5 years). The most common symptoms were abdominal distention or pain or both. Nine (64.3%) and five patients (35.7%) had low-grade and high-grade disease, respectively...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967566/multi-institutional-study-of-peritoneal-sarcomatosis-from-uterine-sarcoma-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#16
Armando Sardi, Arkadii Sipok, Dario Baratti, Marcello Deraco, Paul Sugarbaker, George Salti, Yutaka Yonemura, Paolo Sammartino, Olivier Glehen, Naoual Bakrin, Teresa P Díaz-Montes, Vadim Gushchin
OBJECTIVE: Uterine sarcoma (US) is a rare tumor representing 1% of female genital tract malignancies. Peritoneal sarcomatosis (PS) after US, diminishes median overall survival (OS) and progression-free survival (PFS) with cytoreductive surgery (CRS) alone, with or without systemic chemotherapy is <1 year and 6 months, respectively. A multi-institutional review of PS from US was conducted to evaluate CRS and hyperthermic intraperitoneal chemotherapy (HIPEC) and effects on survival outcomes...
September 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28951264/discussing-sarcoma-risks-during-informed-consent-for-nonhysterectomy-management-of-fibroids-an-unmet-need
#17
Brandon-Luke L Seagle, Amy L Alexander, Anna E Strohl, Shohreh Shahabi
There is no reliable way to distinguish symptomatic uterine fibroids from sarcoma without a surgical specimen. Many women with a uterine sarcoma are initially managed without hysterectomy under a presumed fibroid diagnosis, without understanding sarcoma risks. Currently many alternatives to hysterectomy, including medical and procedural interventions, for treatment of fibroids are promoted. The sarcoma incidence among women with presumed fibroids is 0.29% (1/340) to 0.05% (1/2000). Nonmetastatic leiomyosarcoma has a 63% 5-year survival rate whereas metastatic leiomyosarcoma has a 14% 5-year survival rate...
September 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28938732/prevalence-of-occult-leiomyosarcomas-and-atypical-leiomyomas-after-laparoscopic-morcellation-of-leiomyomas-in-reproductive-age-women
#18
G Pados, D Tsolakidis, V Theodoulidis, A Makedos, T Zaramboukas, B Tarlatzis
STUDY QUESTION: What is the prevalence of leiomyosarcomas and atypical leiomyomas after laparoscopic morcellation of fibroids in reproductive age women? SUMMARY ANSWER: No case of leiomyosarcomas but seven atypical leiomyomas were found in 1216 subjects. WHAT IS KNOWN ALREADY: Although uterine sarcoma is a rare entity affecting usually older peri- or post-menopausal women, the Food and Drug Administration discourages use of laparoscopic power morcellation of uterine fibroids...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28929922/elevated-levels-of-serum-mir-152-and-mir-24-in-uterine-sarcoma-potential-for-inducing-autophagy-via-sirt1-and-deacetylated-lc3
#19
X Tong, X Wang, C Wang, L Li
BACKGROUND: MiRNAs may be associated with the risk of uterine sarcoma and related molecular mechanism remains unclear. METHODS: A total of 101 patients with uterine sarcoma (cases) and 54 healthy subjects (controls) were enrolled. The levels of serum miR-152, miR-205, miR-222, miR-24, miR-150 and sirtuin 1 (SIRT1, an NAD +-dependent class III histone deacetylase) were measured by qRT-PCR. HeLa cells were transfected with the mimics of miR-152 and miR-24. The autophagic rates, and the levels of SIRT1 and acetylation of microtubule-associated protein 1A/1B-light chain 3 (LC3) were measured...
September 20, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28919822/uterine-sarcoma-current-perspectives
#20
REVIEW
Charlotte Benson, Aisha B Miah
Uterine sarcomas comprise a group of rare tumors with differing tumor biology, natural history and response to treatment. Diagnosis is often made following surgery for presumed benign disease. Currently, preoperative imaging does not reliably distinguish between benign leiomyomas and other malignant pathology. Uterine leiomyosarcoma is the most common sarcoma, but other subtypes include endometrial stromal sarcoma (low grade and high grade), undifferentiated uterine sarcoma and adenosarcoma. Clinical trials have shown no definite survival benefit of adjuvant radiotherapy or chemotherapy and have been hampered by the rarity and heterogeneity of these disease types...
2017: International Journal of Women's Health
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