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https://www.readbyqxmd.com/read/28938732/prevalence-of-occult-leiomyosarcomas-and-atypical-leiomyomas-after-laparoscopic-morcellation-of-leiomyomas-in-reproductive-age-women
#1
G Pados, D Tsolakidis, V Theodoulidis, A Makedos, T Zaramboukas, B Tarlatzis
STUDY QUESTION: What is the prevalence of leiomyosarcomas and atypical leiomyomas after laparoscopic morcellation of fibroids in reproductive age women? SUMMARY ANSWER: No case of leiomyosarcomas but seven atypical leiomyomas were found in 1216 subjects. WHAT IS KNOWN ALREADY: Although uterine sarcoma is a rare entity affecting usually older peri- or post-menopausal women, the Food and Drug Administration discourages use of laparoscopic power morcellation of uterine fibroids...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28929922/elevated-levels-of-serum-mir-152-and-mir-24-in-uterine-sarcoma-potential-for-inducing-autophagy-via-sirt1-and-deacetylated-lc3
#2
X Tong, X Wang, C Wang, L Li
BACKGROUND: MiRNAs may be associated with the risk of uterine sarcoma and related molecular mechanism remains unclear. METHODS: A total of 101 patients with uterine sarcoma (cases) and 54 healthy subjects (controls) were enrolled. The levels of serum miR-152, miR-205, miR-222, miR-24, miR-150 and sirtuin 1 (SIRT1, an NAD +-dependent class III histone deacetylase) were measured by qRT-PCR. HeLa cells were transfected with the mimics of miR-152 and miR-24. The autophagic rates, and the levels of SIRT1 and acetylation of microtubule-associated protein 1A/1B-light chain 3 (LC3) were measured...
September 20, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28919822/uterine-sarcoma-current-perspectives
#3
REVIEW
Charlotte Benson, Aisha B Miah
Uterine sarcomas comprise a group of rare tumors with differing tumor biology, natural history and response to treatment. Diagnosis is often made following surgery for presumed benign disease. Currently, preoperative imaging does not reliably distinguish between benign leiomyomas and other malignant pathology. Uterine leiomyosarcoma is the most common sarcoma, but other subtypes include endometrial stromal sarcoma (low grade and high grade), undifferentiated uterine sarcoma and adenosarcoma. Clinical trials have shown no definite survival benefit of adjuvant radiotherapy or chemotherapy and have been hampered by the rarity and heterogeneity of these disease types...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28905201/assessment-of-intratumor-heterogeneity-in-mesenchymal-uterine-tumor-by-an-18-f-fdg-pet-ct-texture-analysis
#4
Tetsuya Tsujikawa, Makoto Yamamoto, Kunihiro Shono, Shizuka Yamada, Hideaki Tsuyoshi, Yasushi Kiyono, Hirohiko Kimura, Hidehiko Okazawa, Yoshio Yoshida
OBJECTIVE: The aim of this study was to retrospectively evaluate the clinical significance of (18)F-FDG PET/CT textural features for discriminating uterine sarcoma from leiomyoma. METHODS: Fifty-five patients with suspected uterine sarcoma based on ultrasound and MRI findings who underwent pretreatment (18)F-FDG PET/CT were included. Fifteen patients were histopathologically proven to have uterine sarcoma, 14 patients by surgical operation and one by biopsy, and 40 patients were diagnosed with leiomyoma by surgical operation or in a follow-up for at least 2 years...
September 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28894063/-pneumothorax-caused-by-multiple-pulmonary-metastases-of-a-uterine-endometrial-stromal-sarcoma-report-of-a-case
#5
Shin Shomura, Hitoshi Suzuki, Masaki Yada, Chiaki Kondo
A 53-year-old woman who had undergone hystero-oophorectomy for uterine endometrial stromal sarcoma in our hospital 9 months previously was referred to our hospital because of bilateral pneumothorax. Chest computed tomography scan on admission revealed multiple thin-walled cavity nodules in both lung and a bilateral pneumothorax, suggesting pulmonary metastases of the uterine endometrial stromal sarcoma. We surgically treated the pneumothorax and diagnosed the nodules as metastatic lesions. They were pathologically diagnosed as metastatic uterine endometrial stromal sarcoma...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28862061/pulmonary-metastasis-of-undifferentiated-uterine-sarcoma-forming-fluid-containing-cyst
#6
Genki Usui, Hirotsugu Hashimoto, Jun Matsumoto, Masaaki Akahane, Hajime Tsunoda, Yuko Sasajima, Hajime Horiuchi
Undifferentiated uterine sarcoma (UUS) is a high-grade sarcoma with no specific differentiation; however, it exhibits variable positivity for CD10 as an immunohistochemical marker of endometrial stroma, suggesting immunohistochemical differentiation into endometrial stroma. It has been reported that some low-grade endometrial stromal sarcoma pulmonary metastatic foci show cystic changes; however, whether pulmonary metastatic UUS foci are solid or cystic remains undescribed. A 63-year-old woman underwent a hysterectomy...
August 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28838761/impact-of-genotypic-and-phenotypic-differences-in-sarcoma-models-on-the-outcome-of-photochemical-internalization-pci-of-bleomycin
#7
Cathrine Elisabeth Olsen, Simen Sellevold, Theodossis Theodossiou, Sebastian Patzke, Kristian Berg
The low curative response to current treatment regimens for most soft tissue sarcomas indicates a strong need for alternative treatment strategies and predictive markers for treatment outcome. PCI (photochemical internalization) is a novel treatment strategy to translocate drugs into cytosol that otherwise would have been degraded in lysosomes. Two highly geno-and phenotypically different uterine and vulvar leiomyosarcoma cell lines, MES-SA and SK-LMS-1, were treated with bleomycin (BLM) activated by PCI (PCIBLM)...
August 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28831418/primary-low-grade-endometrial-stromal-sarcoma-of-the-omentum
#8
Kiran Clair, Juliet Wolford, Sonia Veran-Taguibao, Grace Kim, Ramez N Eskander
•Extra-uterine endometrial stromal sarcoma may arise in endometriosis.•Abdominal exploration for extra pelvic endometriosis is warranted.•Representative endometriotic implants should be resected and/or biopsied if clinically suspicious.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28805609/efficacy-of-pet-ct-to-exclude-leiomyoma-in-patients-with-lesions-suspicious-for-uterine-sarcoma-on-mri
#9
Soshi Kusunoki, Yasuhisa Terao, Takafumi Ujihira, Kazunari Fujino, Hiroshi Kaneda, Miki Kimura, Tsuyoshi Ota, Satoru Takeda
OBJECTIVE: To analyze the efficacy of positron emission tomography/computed tomography (PET/CT) for the diagnosis of uterine sarcoma. MATERIALS AND METHODS: Thirty-four patients evaluated between January 2010 and March 2015 were retrospectively enrolled. All patients in whom uterine sarcoma was suspected based on contrast-enhanced magnetic resonance imaging (MRI) findings (heterogeneous, high signal intensity on T2-weighted images and/or high intensity on T1-weighted images) underwent PET/CT for further assessment...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28803257/synthesis-and-biological-evaluation-of-4-o-acetyl-isoxanthohumol-and-its-analogues-as-antioxidant-and-antiproliferative-agents
#10
Monika Stompor, Marta Świtalska, Rafał Podgórski, Łukasz Uram, David Aebisher, Joanna Wietrzyk
Isoxanthohumol (2) and its 4'-O-monoacylated (3) and 7,4'-O-diacetylated (4) derivatives were synthesized and evaluated in vitro for their cytotoxic activity against several cancer cell lines of various origins: MCF-7 (breast), A549 (lung), MESSA (uterine sarcoma), LoVo (colon), drug-resistant human cancer cells (MESSA/DX and LoVo/DX), glioblastoma (U-118 MG), and also towards the non-cancerous cell line MCF-10A (normal breast cells). An antiproliferative assay indicates that 7,4'-di-O-acylisoxanthohumol (4) has similar cytotoxicity to its precursor, isoxanthohumol (2), against selected cell lines (A549, MES-SA, MES-SA/5DX, and U-118 MG)...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28761924/secondary-uterine-carcinosarcoma-after-concurrent-chemoradiotherapy-for-cervical-cancer-case-reports
#11
Akihiko Wakayama, Wataru Kudaka, Tadaharu Nakasone, Yusuke Taira, Yoichi Aoki
•Secondary uterine sarcomas occur in < 1% of patients treated with CCRT.•Secondary uterine sarcomas can occur > 5 years from CCRT.•The median survival period from the secondary tumor occurrence was only 4 months.•All our patients had heterologous carcinosarcoma of the uterine corpus.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28729098/a-multicentre-retrospective-review-of-clinical-characteristics-of-uterine-sarcoma
#12
Marta Wais, Elissa Tepperman, Marcus Q Bernardini, Lilian T Gien, Waldo Jimenez, Ally Murji
OBJECTIVE: Professional societies have recently urged gynaecologists to counsel patients about the risks of encountering uterine sarcoma at fibroid surgery especially when morcellation is used. Our objective was to learn the preoperative and postoperative characteristics of patients with uterine sarcoma to better counsel patients undergoing surgery for presumably benign fibroids. METHODS: This is a multicentre, retrospective cohort study. Three academic tertiary cancer centres in Southern Ontario over a 13-year period (2001-2014)...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28718636/long-chain-alkyl-esters-of-hydroxycinnamic-acids-as-promising-anticancer-agents-selective-induction-of-apoptosis-in-cancer-cells
#13
José C J M D S Menezes, Najmeh Edraki, Shrivallabh P Kamat, Mahsima Khoshneviszadeh, Zahra Kayani, Hossein Hadavand Mirzaei, Ramin Miri, Nasrollah Erfani, Maryam Nejati, José A S Cavaleiro, Tiago Silva, Luciano Saso, Fernanda Borges, Omidreza Firuzi
Cancer is the major cause of morbidity and mortality worldwide. Hydroxycinnamic acids (HCAs) are naturally occurring compounds and their alkyl esters may possess enhanced biological activities. We evaluated C4, C14, C16, and C18 alkyl esters of p-coumaric, ferulic, sinapic, and caffeic acids (19 compounds) for their cytotoxic activity against four human cancer cells and also examined their effect on cell cycle alteration and apoptosis induction. The tetradecyl (1c) and hexadecyl (1d) esters of p-coumaric acid and tetradecyl ester of caffeic acid (4c), but not the parental HCAs, were selectively effective against MOLT-4 (human lymphoblastic leukemia) cells with IC50 values of 0...
August 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28711930/primary-endometrioid-stromal-sarcomas-of-the-ovary-a-clinicopathological-study-of-14-cases-with-a-review-of-the-literature
#14
Weimin Xie, Xiaoning Bi, Dongyan Cao, Jiaxin Yang, Keng Shen, Yan You
PURPOSE: Primary endometrioid stromal sarcomas (ESS) of the ovary are rare mesenchymal tumors with scarce data on their behavior and optimal treatment. We aimed to describe the clinicopathologic features and outcome among patients with primary ovarian ESS. RESULTS: The age of the patients ranged from 34 to 61 years (mean: 49.1 years, median: 51.5 years). The most common symptoms were abdominal distention or pain or both. Nine (64.3%) and five patients (35.7%) had low-grade and high-grade disease, respectively...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700435/ifitm1-outperforms-cd10-in-differentiating-low-grade-endometrial-stromal-sarcomas-from-smooth-muscle-neoplasms-of-the-uterus
#15
Aurelia Busca, Previn Gulavita, Carlos Parra-Herran, Shahidul Islam
Distinguishing between uterine neoplasms of smooth muscle and endometrial stromal origin is a frequent diagnostic challenge. We investigated the staining pattern of interferon-induced transmembrane protein-1 (IFITM1), a novel endometrial stromal marker, in endometrial and smooth muscle uterine neoplasms and compared it with CD10 in its ability to differentiate between these two groups. Immunohistochemistry for IFITM1 and CD10 was performed in 20 cases of smooth muscle neoplasms (10 cases leiomyoma, 10 cases leiomyosarcoma), 14 cases of endometrial stromal sarcoma (ESS) (12 cases of low grade and 2 cases of high grade) and 12 cases of carcinosarcoma...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28696085/does-fibroids-surgery-by-endoscopy-or-laparotomy-represent-a-malignancy-threat
#16
Liselotte Mettler, Khulkar Abdusattarova, Ibrahim Alkatout
BACKGROUND: 1) to estimate the incidence of unsuspected uterine sarcoma in patients after myomectomies and hysterectomies for benign uterine fibroids. 2) to assessed the incidence of uterine sarcomas among patient who had uterine fibroids or a suspicion of uterine sarcoma before undergoing the surgical procedures. METHODS: Retrospective study in single center university hospital. Patient 's records with uterine fibroids and uterine sarcoma from 2003 to 2015 collected...
July 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28678537/pharmacokinetic-drug-evaluation-of-pazopanib-for-the-treatment-of-uterine-leiomyosarcomas
#17
REVIEW
Simone Ferrero, Umberto Leone Roberti Maggiore, Nicoletta Aiello, Fabio Barra, Antonino Ditto, Giorgio Bogani, Francesco Raspagliesi, Domenica Lorusso
Uterine leiomyosarcomas (ULMS) represent 1.3% of all uterine malignant tumors. Surgery is the curative treatment for patients with early stage disease. In case of advanced, persistent or recurrent tumor, chemotherapy represents the standard of care, but these patients have a poor prognosis. As the results with available therapies are far from being satisfactory, research is focusing on identification of new compounds. In 2012 the Food and Drug Administration (FDA) licensed pazopanib for the treatment of advanced soft-tissue sarcomas failing previous chemotherapy...
August 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28676623/-iii-endometrial-carcinoma-and-uterine-sarcoma
#18
Kenichi Harano
No abstract text is available yet for this article.
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28643014/neuron-navigator-2-and-cyclin-d2-are-new-candidate-prognostic-markers-in-uterine-sarcoma
#19
Ben Davidson, Ellen Hellesylt, Arild Holth, Håvard Emil Danielsen, Tone Skeie-Jensen, Betina Katz
The objective of this study was to validate the diagnostic and clinical role of four protein products of genes previously found to be differentially expressed in uterine low-grade endometrial stromal sarcoma (LG-ESS) compared to uterine leiomyosarcoma (LMS). Protein expression by immunohistochemistry of transgelin (TGLN), neuron navigator-2 (NAV2), fatty acid binding protein-3 (FABP3), and cyclin D2 (CCND2) was analyzed in 305 uterine sarcomas (231 LMS, 74 LG-ESS). Expression was analyzed for association with clinicopathologic parameters and survival...
June 22, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28641661/-clinical-and-pathologic-features-of-myeloid-sarcoma
#20
Ya-Jun Jiang, Hong-Xia Wang, Wan-Chuan Zhuang, Hao Chen, Chang Zhang, Xiu-Mei Li, Gui-Hua Zhu, Yao He
OBJECTIVE: To explore the clinicopathologic features, differential diagnosis and therapy of myeloid sarcoma. METHODS: The clinical data including clinical manifestations, laboratorial tests, histopathologicical examination, immunohistochemistry and clinical prognosis of 10 patients with myeloid sarcoma were analyzed retrospectively. Among 10 patients, 5 male and 5 female, aged 23 to 71 years old (median = 36 years). RESULTS: 2 cases of myeloid sarcoma were secondary from chronic myeloid leukemia, and 1 cases of myeloid sarcoma occurred after the allogeneic hematopoietic stem cell transplantation due to acute myeloid leukemia, and the others lacked the anamnesis of malignancies...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
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