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https://www.readbyqxmd.com/read/29325966/role-of-intraoperative-ultrasound-to-extend-the-application-of-minimally-invasive-surgery-for-treatment-of-recurrent-gynecological-cancer
#1
Floriana Mascilini, Lorena Quagliozzi, Francesca Moro, Maria Cristina Moruzzi, Valerio Gallotta, Salvatore Gueli Alletti, Giovanni Scambia, Antonia Carla Testa, Anna Fagotti
STUDY OBJECTIVE: To describe the potential role of intraoperative ultrasound (IOUS) in the detection and localization of recurrent disease in gynecological cancer patients during minimally invasive surgery (MIS). DESIGN: A prospective cohort study (Canadian Task Force II-1). SETTING: A University hospital. PATIENTS: From November 2015 to February 2017, 51 gynecological cancer patients with isolated recurrent disease and candidate for secondary cytoreductive surgery (SCS) were treated by MIS...
January 8, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29320751/uterine-rhabdomyosarcoma-in-adults
#2
Andre Pinto, Ryan M Kahn, Andrew E Rosenberg, Brian Slomovitz, Charles Matthew Quick, Michella K Whisman, Marilyn Huang
Rhabdomyosarcoma (RMS) is an aggressive mesenchymal tumor most commonly diagnosed in the pediatric population, and when occurring in adults, tends to develop in the deep soft tissue of the limbs. Primary uterine RMS comprises an even more restricted subset, with little known or reported when compared to most other gynecologic sarcomas. Our goal with this study was to retrospectively evaluate cases from two academic institutions and describe the main histopathologic findings of this rare gynecologic malignancy...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29303932/the-clinicopathological-study-of-21-cases-with-uterine-smooth-muscle-tumors-of-uncertain-malignant-potential-centralized-review-can-purify-the-diagnosis
#3
Derman Basaran, Alp Usubutun, Mehmet Coskun Salman, Mehmet Ali Narin, Gokhan Boyraz, Osman Turkmen, Gunsu Comert Kimyon, Alper Karalok, Dilek Bulbul, Taner Turan, Nejat Ozgul, Kunter Yuce
OBJECTIVE: The objective of this study was to investigate the clinicopathological features and factors associated with recurrence in patients with uterine smooth muscle tumor of uncertain malignant potential (STUMP). METHODS: Forty-six cases diagnosed between 2000 and 2014 from 2 tertiary centers underwent blind slide review. Initial diagnosis included smooth muscle tumors with equivocal diagnosis, STUMPs, and cases that were named as leiomyosarcomas (LMS) or low-grade LMS despite not fulfilling the Stanford criteria...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29281902/treatment-of-uterine-sarcoma-with-rad-p53-gendicine%C3%A2-followed-by-chemotherapy-clinical-study-on-tp53-gene-therapy
#4
Yu Xia, Zhenhua Du, Xinyan Wang, Xiuqin Li
AIM: The purpose of this study was to evaluate the efficacy of rAd-p53 (Gendicine®) followed by chemotherapy in the treatment of uterine sarcoma. METHODS: Retrospective analysis of the 12 cases of uterine sarcoma in Shengjing hospital. Among the 12 patients, 1 suffered from primary cancer and 11 suffered from recurrent cancer. The interval between the first operation and the diagnosis of recurrence of 11 cases, PFS1 (Progression-Free Survival time1) was 1-18 months (median 3 months)...
December 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29280706/renal-endometriosis-mimicking-complicated-cysts-of-kidney-report-of-two-cases
#5
D Giambelluca, D Albano, E Giambelluca, A Bruno, F Panzuto, A Agrusa, G Di Buono, F Cannizzaro, Cesare Gagliardo, M Midiri, R Lagalla, G Salvaggio
Endometriosis is a common gynecologic disorder characterized by ectopic endometrial tissue growth outside the uterine cavity. Although usually occurring in pelvic organs, endometrial lesions may involve urinary tract. Renal endometriosis is extremely rare and it has only occasionally been reported in the past. We report two cases of patients with renal cystic lesions, incidentally found at imaging techniques during oncologic follow-up for gastric sarcoma and melanoma, initially misinterpreted as complicated haemorrhagic cysts and then histologically characterized as renal localizations of extragenital endometriosis...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29275929/endometrial-stromal-sarcomas-and-related-neoplasms-new-developments-and-diagnostic-considerations
#6
REVIEW
Lien Hoang, Sarah Chiang, Cheng-Han Lee
Our understanding of endometrial stromal sarcomas has evolved dramatically since their earliest descriptions from over a century ago. Initial studies focused on establishing the relationship between histological appearances of endometrial stromal sarcomas and their clinical outcomes. Studies performed in the last decade have uncovered several recurrent cytogenetic aberrations occurring in low- and high-grade endometrial stromal sarcomas. Low-grade endometrial stromal sarcomas bear close histopathological resemblance to proliferative-type endometrial stroma, and approximately half harbour t(7;17)(p15;q21) resulting in JAZF1-SUZ12 gene fusion...
December 21, 2017: Pathology
https://www.readbyqxmd.com/read/29248197/significance-of-venous-thromboembolism-in-women-with-uterine-carcinosarcoma
#7
Koji Matsuo, Malcolm S Ross, Dwight D Im, Merieme M Klobocista, Stephen H Bush, Marian S Johnson, Tadao Takano, Erin A Blake, Yuji Ikeda, Masato Nishimura, Yutaka Ueda, Masako Shida, Kosei Hasegawa, Tsukasa Baba, Sosuke Adachi, Takuhei Yokoyama, Shinya Satoh, Hiroko Machida, Shiori Yanai, Keita Iwasaki, Takahito M Miyake, Satoshi Takeuchi, Munetaka Takekuma, Tadayoshi Nagano, Mayu Yunokawa, Tanja Pejovic, Kohei Omatsu, Mian M K Shahzad, Joseph L Kelley, Frederick R Ueland, Lynda D Roman
OBJECTIVE: To identify risk factors for venous thromboembolism (VTE) and to examine the association of VTE and survival in women with uterine carcinosarcoma. METHODS: This multicenter retrospective study examined 906 women who underwent primary surgical treatment for stage I-IV uterine carcinosarcoma. Time-dependent analyses were performed for cumulative incidence of VTE after surgery on multivariate models. RESULTS: There were 72 (7.9%) women who developed VTE after surgery with 1-, 2-, and 5-year cumulative incidences being 5...
December 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29245257/endometrial-stromal-sarcoma-in-combination-with-mixed-type-endometrial-carcinomas-a-case-report-and-literature-review
#8
REVIEW
Xiao-Xin Xiu, Hua-Li Wang, Lv Yun-Yi, Kong Fan-Dou, Hou Jin-Ping
RATIONALE: Endometrial stromal sarcoma (ESS) is rare, representing only approximately 0.2% of all uterine malignancies. Mixed type endometrial carcinomas (MT-ECs) are rare tumors with both type I and II features, and are difficult to diagnose. Cases of ESS and MT-ECs coexisting in the same patient are extremely rare. This study aimed to describe a case of ESS in combination with MT-ECs in a 47-year-old premenopausal woman. PATIENT CONCERNS: A woman presented to the hospital complaining of occasional abdominal pain and had high tumor markers: cancer antigen (CA) 19-9 (263...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29238287/survey-among-esge-members-on-leiomyosarcoma-morcellation-incidence
#9
Vasilios Tanos, Hans Brölmann, Rudi Leon DeWilde, Peter O'Donovan, Elina Symeonidou, Rudi Campo
Background: Increased awareness of leiomyosarcoma (LMS) risk during myomectomy or hysterectomy is essential. Objective and correct reasoning should prevail on any decision regarding the extent and type of surgery to employ. The anticipated risk of a sarcoma after myoma or uterus morcellation is low, and the frequency of leiomyosarcoma especially in women below the age of 40 is very rare. The prevalence data has a wide range and is therefore not reliable. The European Society of Gynaecological Endoscopy (ESGE) initiated a survey among its members looking into the frequency of morcellated leiomyosarcoma after endoscopic surgery...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29220301/soft-tissue-and-uterine-leiomyosarcoma
#10
Suzanne George, César Serrano, Martee L Hensley, Isabelle Ray-Coquard
Leiomyosarcoma (LMS) is one of the most common subtypes of soft tissue sarcoma in adults and can occur in almost any part of the body. Uterine leiomyosarcoma is the most common subtype of uterine sarcoma. Increased awareness of this unique histology has allowed for the development of drugs that are specific to LMS and has begun to shed light on the similarities and possible unique aspects of soft tissue and uterine LMS. In this review, we summarize the current understanding of the epidemiology, diagnosis, genomics, and treatment options for LMS...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218853/rna-sequencing-identifies-novel-greb1-ncoa2-fusion-gene-in-a-uterine-sarcoma-with-the-chromosomal-translocation-t-2-8-p25-q13
#11
Marta Brunetti, Ioannis Panagopoulos, Ludmila Gorunova, Ben Davidson, Sverre Heim, Francesca Micci
Sarcomas account for 3% of all uterine malignancies and many of them are characterized by acquired, specific fusion genes whose detection has increased pathogenetic knowledge and diagnostic precision. We describe a novel fusion gene, GREB1-NCOA2, detected by transcriptome sequencing and validated by RT-PCR and Sanger sequencing in an undifferentiated uterine sarcoma. The chimeric transcript was an in-frame fusion between exon 3 of GREB1 and exon 15 of NCOA2. The fusion is reported here for the first time, but it involves the GREB1 gene, an important promoter of tumor growth and progression, and NCOA2 which is known to be involved in transcriptional regulation...
December 8, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29200103/bcor-internal-tandem-duplication-in-high-grade-uterine-sarcomas
#12
Adrián Mariño-Enriquez, Alexandra Lauria, Joanna Przybyl, Tony L Ng, Magdalena Kowalewska, Maria Debiec-Rychter, Raji Ganesan, Vaiyapuri Sumathi, Suzanne George, W Glenn McCluggage, Marisa R Nucci, Cheng-Han Lee, Jonathan A Fletcher
Endometrial stromal sarcomas (ESSs) are mesenchymal uterine tumors characterized by recurrent genetic events, most commonly chromosomal rearrangements, that create oncogenic gene fusions. High-grade endometrial stromal sarcomas (HG-ESSs), as defined in the 2014 World Health Organization Classification, typically contain oncogenic YWHAE-NUTM2 fusions; however, although not well characterized, there are tumors morphologically overlapping with HG-ESS that do not contain the YWHAE-NUTM2 fusions. These fusions are also found in certain pediatric primitive sarcomas, including clear cell sarcoma of the kidney and soft tissue undifferentiated round cell sarcoma of infancy...
December 1, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29192652/zc3h7b-bcor-high-grade-endometrial-stromal-sarcomas-a-report-of-17-cases-of-a-newly-defined-entity
#13
Natasha Lewis, Robert A Soslow, Deborah F Delair, Kay J Park, Rajmohan Murali, Travis J Hollmann, Ben Davidson, Francesca Micci, Ioannis Panagopoulos, Lien N Hoang, Javier A Arias-Stella, Esther Oliva, Robert H Young, Martee L Hensley, Mario M Leitao, Meera Hameed, Ryma Benayed, Marc Ladanyi, Denise Frosina, Achim A Jungbluth, Cristina R Antonescu, Sarah Chiang
High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE-NUTM2 fusion. Triggered by three initial endometrial stromal sarcomas with ZC3H7B-BCOR fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28-71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion...
December 1, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29185261/pazopanib-monotherapy-in-the-treatment-of-pretreated-metastatic-uterine-sarcoma-a-single-center-retrospective-study
#14
Hyun Jun Kim, Youjin Kim, Su Jin Lee, Jeeyun Lee, Se Hoon Park
OBJECTIVE: In the treatment of metastatic soft tissue sarcoma (STS), pazopanib is considered a standard treatment after failure of chemotherapy. We retrospectively investigated outcomes of pazopanib in patients with metastatic uterine STS. METHODS: A retrospective study was performed on 35 consecutive patients with uterine STS treated with oral pazopanib 800 mg daily as salvage therapy for metastatic disease between September 2013 and December 2015. Endpoints included response rate, survival, and safety...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29151911/multiple-pulmonary-metastases-with-halo-sign-from-malignant-mixed-m%C3%A3-llerian-tumors
#15
Hong-Wei Tian, Wei-Bing Yang, Meng-Jie Yang, Jing-Yuan Liu, Jian-Chu Zhang, Xiao-Nan Tao, Qiong Zhou
The lungs are one of the most common organs to which cancer metastasizes, but are a location not common for uterine sarcoma. A malignant mixed Müllerian tumor (MMMT) of the uterus is an extremely rare and aggressive sarcoma, characterized by a mixture of epithelial and mesenchymal components. There are few reports regarding the pulmonary metastasis from MMMTs. The present study presents the case of a 58-year-old woman with hemoptysis and post-menopausal vaginal bleeding. The woman was initially diagnosed with invasive aspergillosis based on a chest computed tomography (CT) scan showing multiple pulmonary nodular opacities surrounded by a ground-glass attenuation halo (halo-sign)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29149644/assessing-the-risk-of-laparoscopic-morcellation-of-occult-uterine-sarcomas-during-hysterectomy-and-myomectomy-literature-review-and-the-isge-recommendations
#16
REVIEW
Ornella Sizzi, Lucia Manganaro, Alfonso Rossetti, Matteo Saldari, Giuseppe Florio, Alessandro Loddo, Robert Zurawin, Bruno van Herendael, Dusan Djokovic
OBJECTIVE: This project of the International Society for Gynecologic Endoscopy (ISGE) had the objective to review the literature and provide recommendations on the occult sarcoma risk assessment in patients who are candidates for minimally invasive gynecological surgery involving intra-abdominal electromechanical tissue morcellation. STUDY DESIGN: The ISGE Task Force for Estimation of the Risk in Endoscopic Morcellation initially defined key topics and clinical questions which may guide a comprehensive preoperative patient assessment...
January 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29136690/-values-of-jazf1-gene-rearrangement-detected-by-fluorescence-in-situ-hybridization-in-diagnosis-of-endometrial-stromal-tumours
#17
Q M Bai, B Chang, X Y Tu, R Bi, Y F Cheng, D Huang, X L Zhu, L J Wu, X Zhang, X Y Zhou, W T Yang
Objective: To investigate the role of JAZF1 gene rearrangement in the diagnosis and differential diagnosis of endometrial stromal sarcomas by fluorescence in situ hybridization (FISH). Methods: JAZF1 gene rearrangement was analyzed by FISH in 129 cases of ESS diagnosed from January 2008 to December 2016 including 105 cases of low-grade endometrial stromal sarcoma (LG-ESS), 21 cases of high-grade endometrial stromal sarcoma (HG-ESS) and 3 cases of undifferentiated uterine sarcoma (UUS). Sixteen cases of the related tumours in uterus were also collected as control group...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29133752/proportion-of-uterine-malignant-tumors-in-patients-with-laparoscopic-myomectomy-a-national-multicenter-study-in-china
#18
Hua Yang, Xiao-Chuan Li, Chen Yao, Jing-He Lang, Hang-Mei Jin, Ming-Rong Xi, Gang Wang, Lu-Wen Wang, Min Hao, Yan Ding, Jie Chen, Jian-Qing Zhang, Lu Han, Cheng-Xiu Guo, Xiang Xue, Yan Li, Jian-Hua Zheng, Man-Hua Cui, Huai-Fang Li, Guang-Shi Tao, Long Chen, Su-Min Wang, An-Wei Lu, Ze-Hua Huang, Qing Liu, Ya-Li Zhuang, Xiang-Hua Huang, Gen-Hai Zhu, Ou-Ping Huang, Li-Na Hu, Mu-Jun Li, Hong-Lin Zhou, Jing-Hui Song, Lan Zhu
BACKGROUND: The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. METHODS: A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29128980/reducing-the-spread-of-occult-uterine-sarcoma-at-the-time-of-minimally-invasive-gynecologic-surgery
#19
Marron Wong, Rudy Leon De Wilde, Keith Isaacson
PURPOSE: This review covers the most recent evidence to discuss the incidence of occult uterine sarcoma, whether morcellation increases tumor dissemination or mortality, and whether there is a difference between different types of morcellation. We will also discuss techniques to reduce the spread of an undiagnosed uterine sarcoma. METHOD: A comprehensive literature search was made in Pubmed, Medline, the Cochrane Library, and Google Scholar for articles related to the incidence of occult uterine sarcoma after morcellation...
November 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29126743/benign-and-malignant-pathology-of-the-uterus
#20
REVIEW
V Tanos, K E Berry
The diagnosis of a uterine myoma size and location can be very precise when a 3D sonograph and knowledge are available. The majority of fibroids are asymptomatic, and expectant management is recommended. In young patients, fibroids cause infertility and in middle-aged women, abnormal uterine bleedings. Laparoscopic myomectomy is the preferred way of surgery for IM and SS fibroids, versus hysteroscopy for SM fibroids. In both cases, the size, number of fibroids and the surgeon's experience determine the limitations of the MIGS...
October 16, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
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