Yiling Liu, Yaqi Ouyang, Liu Yu, Peng Wang, Zhangwen Peng, Hengdeng Liu, Shixin Zhao, Hanwen Wang, Ziheng Zhou, Yang Deng, Yang Liu, Julin Xie
Skin graft rejection is a significant challenge in skin allografts for skin defects, particularly in extensive burn injury patients when autografts are insufficient. Enhancing the survival duration of allogeneic skin grafts can improve the success rate of subsequent autologous skin grafting, thereby promoting the therapeutic efficacy for wound healing. Rapamycin (Rapa), a potent immunosuppressant with favorable efficacy in organ transplantation, is limited by its systemic administration-associated toxicity and side effects...
December 25, 2023: International Journal of Pharmaceutics