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Hypertension treatment

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https://www.readbyqxmd.com/read/29457348/fixed-dose-vs-free-dose-combinations-for-the-management-of-hypertension-an-analysis-of-81-958-patients
#1
Peter Bramlage, Stefanie Schmidt, Helen Sims
Fixed-dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed-dose or free-dose (freeDC) ramipril/amlodipine (R/A) or candesartan/amlodipine (C/A) combination treatment initiation were assessed. 71 463 patients were prescribed R/A and 10 495 C/A. For both R/A and C/A, FDC patients were younger (both P < .001) and less comorbid. Prior MI (OR: 0.61 and 0.60), prior stroke (OR: 0.68 and 0.70) and CHD (OR: 0.68 and 0.64) were negatively associated with FDC use, whereas hyperlipidemia was positively associated (OR: 1...
February 19, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29456869/cognitive-fluctuations-in-parkinson-s-disease-dementia-blood-pressure-lability-as-an-underlying-mechanism
#2
David E Riley, Alberto J Espay
Background: Cognitive fluctuations refer to alterations in cognition, attention, or arousal occurring over minutes to hours, most commonly in patients with dementias associated with advanced Lewy body pathology. Their pathophysiologic underpinning remains undetermined. Case presentation: We documented serial blood pressure (BP) measurements in an 86-year-old man with Parkinson's disease dementia experiencing cognitive fluctuations during an office visit. This patient's associated dysautonomia included labile BP with orthostatic hypotension and nocturnal hypertension...
2018: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/29456639/analysis-of-effect-of-1%C3%AE-hydroxyvitamin-d3-on-benign-paroxysmal-positional-vertigo-and-risk-factors
#3
Xiang Gu, Feilin Dong, Jianhua Gu
The purpose of this study was to investigate the curative effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). Fifty BPPV patients diagnosed in the ENT Department of Anzhen Hospital from October 2015 to December 2016 were randomly selected as the treatment group, and treated with 0.25 µg 1α-hydroxyvitamin D3 once per day, in addition to the routine diagnosis and treatment. Moreover, 50 BPPV patients in the same period were selected as the control group, and received the routine diagnosis and treatment...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456411/clinical-utility-of-hepatitis-b-surface-antigen-kinetics-in-treatment-na%C3%A3-ve-chronic-hepatitis-b-patients-during-long-term-entecavir-therapy
#4
Tien-Ching Lin, Yen-Cheng Chiu, Hung-Chih Chiu, Wen-Chun Liu, Pin-Nan Cheng, Chiung-Yu Chen, Ting-Tsung Chang, I-Chin Wu
AIM: To investigate the utility of hepatitis B surface antigen (HBsAg) kinetics in chronic hepatitis B patients during long-term entecavir treatment. METHODS: This retrospective study included treatment-naïve chronic hepatitis B patients who received at least 2 years of consecutive entecavir treatment. Patients were followed up at three to six month intervals with liver biochemistry, hepatitis B virus DNA, and abdominal sonography. In hepatitis B e antigen (HBeAg)-positive patients, HBeAg levels were assessed every three to six month until results became negative...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29456380/moxibustion-artemisia-plant-at-acupuncture-point-as-alternative-therapy-in-hypertension-a-promising-approach
#5
Mohammad Jamshed Siddiqui, Mohamad Fadly Bin Kamarudin, Abdul Kareem Mohammed Al-Shami, Siti Zaiton Mat So'ad, Shazia Qasim Jamshed
Hypertension is a pathological condition in which the blood pressure is higher than under normal physiological conditions, i.e., 140/90 mmHg or higher. Blood pressure is measured as the force exerted by the blood pumped by the heart against the walls of arteries (aorta) and distributed throughout the body. Use of complementary and alternative medicine as a cure for hypertension is a common phenomenon because of the high risk of cardiovascular complications and kidney diseases caused by conventional Western medicine...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456229/page-kidney-a-rare-but-surgically-treatable-cause-of-hypertension
#6
Ashok Kumar Sokhal, Gaurav Prakash, Durgesh Kumar Saini, Kawaljit Singh, Satyanarayan Sankhwar, Bhupendra Pal Singh
The Page kidney is a rare phenomenon. External renal parenchymal compression is the culprit. We report two cases of young males with flank pain, renal mass, and hypertension with history of blunt abdominal trauma. Initially, hypertension was controlled by angiotensin-converting enzyme (ACE) inhibitors but gradually became refractory to medical treatment. Laparoscopic nephrectomy was performed in both patients. We emphasize the Page kidney as a cause of hypertension in young patients, presenting with flank pain and renal mass with or without complications of hypertension...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456025/effectiveness-of-user-and-expert-driven-web-based-hypertension-programs-an-rct
#7
Sam Liu, Dina Brooks, Scott G Thomas, Gunther Eysenbach, Robert P Nolan
INTRODUCTION: The effectiveness of self-guided Internet-based lifestyle counseling (e-counseling) varies, depending on treatment protocol. Two dominant procedures in e-counseling are expert- and user-driven. The influence of these procedures on hypertension management remains unclear. The objective was to assess whether blood pressure improved with expert-driven or user-driven e-counseling over control intervention in patients with hypertension over a 4-month period. STUDY DESIGN: This study used a three-parallel group, double-blind randomized controlled design...
February 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29455905/ventriculoperitoneal-shunt-treatment-in-a-pregnant-renal-transplant-recipient-with-idiopathic-intracranial-hypertension-case-report-and-review-of-the-literature
#8
Ebru Apaydın Doğan, Selen Doğan, Ethem Taner Göksu, Sibel Özkaynak, Çile Aktan, İnanç Mendilcioğlu
Idiopathic intracranial hypertension (IIH) is a relatively uncommon disorder characterised by raised intracranial pressure without an established pathogenesis. Diagnosis of IIH requires the demonstration of symptoms and signs referable only to elevated intracranial pressure; cerebrospinal fluid (CSF) opening pressure >25cm H2 O measured in the lateral decubitus position; normal CSF composition; and no evidence for an underlying structural cause demonstrated by using MRI or contrast-enhanced CT scan for typical patients and MRI and MR venography for atypical patients such as man, children and those with low body mass index...
February 6, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29455406/conversional-weight-loss-surgery-an-australian-experience-of-converting-laparoscopic-adjustable-gastric-bands-to-laparoscopic-sleeve-gastrectomy
#9
M Devadas, D J Ku
BACKGROUND: Bariatric surgery is the most effective treatment for severe obesity, capable of producing more than 50% excess weight loss at 10-year follow-up (James Clin Dermatol 1; 22:276-80; O'Brien Br J Surg 2; 102:611-17; Buchwald et al. Metab Syndr 3; 347-56). The success of bariatric surgery extends far beyond weight loss, with up to 80-90% of patients having improvement or resolution of many of their weight-related co-morbidities including type II diabetes mellitus and hypertension (Puzziferri et al...
February 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29454617/antihypertensive-potential-of-linalool-and-linalool-complexed-with-%C3%AE-cyclodextrin-effects-of-subchronic-treatment-on-blood-pressure-and-vascular-reactivity
#10
Samuel Barbosa Camargo, Letícia Oliveira Simões, Carla Fiama de Azevedo Medeiros, Anderson de Melo Jesus, Josmara Bartolomei Fregoneze, Afrânio Evangelista, Cristiane Flora Villarreal, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Darizy Flavia Silva
Linalool (LIN) is a monoterpene alcohol present in some aromatic medicinal plants with biological activities that can impact cardiovascular diseases. This chemical class is highly volatile and β-cyclodextrin (β-CD) has been employed to improve the pharmacological properties of monoterpenes. Thus, the aim of this study was to evaluate the cardiovascular effects of LIN free focusing on the antihypertensive properties of this monoterpene and to study whether LIN, complexed in β-cyclodextrin (LIN-βCD) is able to improve the pharmacological activity of LIN...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29454558/clinical-characteristics-and-management-of-patients-with-atrial-fibrillation-treated-with-direct-oral-anticoagulants-according-to-blood-pressure-control
#11
M de la Figuera, S Cinza, I Egocheaga, N Marín, M A Prieto
OBJECTIVE: To determine the clinical characteristics and management of hypertensive patients with nonvalvular atrial fibrillation (AF) treated with direct oral anticoagulants (DOACs) according to blood pressure (BP) control. METHODS: For this purpose, data from two observational, cross-sectional and multicenter studies were combined. In both studies, patients on chronic treatment with anticoagulants and that were on current treatment with DOACs at least for 3 months were included...
February 14, 2018: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29454466/-dermoid-cysts-of-the-posterior-cerebral-fossa-in-children-revealed-by-recurrent-aseptic-meningitis-report-of-two-cases-and-a-review-of-the-literature
#12
R Kouadria, M Derkaoui
INTRODUCTION: Dermoid cysts of central nervous system are very rare. The usual clinical presentation is dominated by intracranial hypertension, epilepsy and cranial palsy. The revelation mode could be recurrent aseptic meningitis. AIM: The aim of this case report is to consider the dermoid cyst as regards the differential diagnosis in children treated for recurrent aseptic meningitis to avoid misdiagnosis and ice qui a orienté le diagnostic à une méningitnadequate treatment...
February 14, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29454329/bilateral-acute-angle-closure-glaucoma-following-tramadol-subcutaneous-administration
#13
Anis Mahmoud, Fatma Abid, Imen Ksiaa, Sourour Zina, Riadh Messaoud, Moncef Khairallah
BACKGROUND: To report a case of bilateral acute angle closure-glaucoma following the use of subcutaneous Tramadol. CASE PRESENTATION: A 42-year-old healthy man with unremarkable past medical and ocular history, was admitted to the Orthopedic Department for surgical treatment of a bilateral open fracture of the femur following a road accident. Three hoursafterTramadolsubcutaneous injection, the patient complained of a bilateral acute painful visual loss with persistent vomiting...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29453947/evaluation-of-the-effects-of-rp5063-a-novel-multimodal-serotonin-receptor-modulator-as-single-agent-therapy-and-co-administrated-with-sildenafil-bosentan-and-treprostinil-in-a-monocrotaline-induced-pulmonary-arterial-hypertension-rat-model
#14
Laxminarayan Bhat, Jon Hawkinson, Marc Cantillon, Dasharatha G Reddy, Seema R Bhat, Charles-E Laurent, Annie Bouchard, Marzena Biernat, Dany Salvail
Pulmonary arterial hypertension (PAH), a condition that is defined by pulmonary vasculature constriction and remodeling, involves dysfunctional signaling of the serotonin (5-HT) receptors, 5-HT 2/2B/7 . In a rat model of monocrotaline (MCT)-induced PAH, the effectiveness of RP5063 (RP), a dopamine and 5-HT receptor modulator, was evaluated as monotherapy and as an adjunct to standard PAH treatments. After a single 60mg/kg dose of MCT, rats received vehicle (MCT+Veh; gavage twice-daily [b.i.d.]), RP (10mg/kg; gavage b...
February 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29453922/a-short-review-of-primary-aldosteronism-in-a-question-and-answer-fashion
#15
Frederick-Anthony Farrugia, Nicolaos Zavras, Georgios Martikos, Panagiotis Tzanetis, Anestis Charalampopoulos, Evangelos P Misiakos, Dimitrios Sotiropoulos, Nikolaos Koliakos
OBJECTIVES: The aim of this study was to present up to date information concerning the diagnosis and treatment of primary aldosteronism (PA). PA is the most common cause of endocrine hypertension. It has been reported up to 24% of selective referred hypertensive patients. METHODS: We did a search in Pub-Med and Google Scholar using the terms: PA, hyperaldosteronism, idiopathic adrenal hyperplasia, diagnosis of PA, mineralocorticoid receptor antagonists, adrenalectomy, and surgery...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29453084/solid-lipid-nanoparticles-as-an-efficient-drug-delivery-system-of-olmesartan-medoxomil-for-the-treatment-of-hypertension
#16
Nilima T Pandya, Parva Jani, Jigar Vanza, Hemal Tandel
The aim of the current investigation was to develop solid lipid nanoparticles of olmesartan medoxomil using hot homogenization method to improve its oral bioavailability. Central composite design was applied to optimize the formulation variables; lipid X1 (Glyceryl monostearate) and surfactant X2 (Poloxamer: Tween 80). The particle sizes were in the nanometer range and spherical shaped for all prepared solid lipid nanoparticles formulations and the zeta potential absolute values were high, predicting good long-term stability...
February 9, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29453020/2018-consensus-of-the-taiwan-society-of-cardiology-and-the-diabetes-association-of-republic-of-china-taiwan-on-the-pharmacological-management-of-patients-with-type-2-diabetes-and-cardiovascular-diseases
#17
Chern-En Chiang, Shih-Yi Lin, Tsung-Hsien Lin, Tzung-Dau Wang, Hung-I Yeh, Jung-Fu Chen, Chia-Ti Tsai, Yi-Jen Hung, Yi-Heng Li, Ping-Yen Liu, Kuan-Cheng Chang, Kang-Ling Wang, Ting-Hsing Chao, Kou-Gi Shyu, Wei-Shiung Yang, Kwo-Chang Ueng, Pao-Hsien Chu, Wei-Hsian Yin, Yen-Wen Wu, Hao-Min Cheng, Shyi-Jang Shin, Chien-Ning Huang, Lee-Ming Chuang, Shing-Jong Lin, San-Jou Yeh, Wayne Huey-Herng Sheu, Jiunn-Lee Lin
The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). About two-thirds of death in type 2 diabetes are due to ASCVD, including 40% from coronary heart disease (CHD), 15% from heart failure (HF), and 10% from stroke. The association between hyperglycemia and elevated CV risk has been demonstrated in multiple cohort studies. However, clinical trials of intensive glucose reduction did not significantly reduce macrovascular outcomes...
February 13, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29452492/treatment-patterns-and-medicaid-spending-in-comorbid-schizophrenia-populations-once-monthly-paliperidone-palmitate-vs-oral-atypical-antipsychotics
#18
Rhiannon Kamstra, Dominic Pilon, Patrick Lefebvre, Bruno Emond, Kruti Joshi
OBJECTIVE: To compare treatment patterns and Medicaid spending between schizophrenia patients initiating once-monthly paliperidone palmitate (PP1M) and oral atypical antipsychotics (OAA) within four comorbid populations: cardiovascular disease (CVD), diabetes, hypertension, and obesity. METHODS: Five-state Medicaid data identified comorbid adults with schizophrenia initiating PP1M or OAA (index) from 09/2009 balanced with inverse probability of treatment weighting...
February 16, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29451696/randomized-phase-2-trial-of-pemetrexed-pemetrexed-bevacizumab-and-pemetrexed-carboplatin-bevacizumab-in-patients-with-stage-iiib-iv-non-small-cell-lung-cancer-and-an-eastern-cooperative-oncology-group-performance-status-of-2
#19
David R Spigel, John D Hainsworth, Mathew J Joseph, Dianna L Shipley, M Kelly Hagan, Dana S Thompson, Howard A Burris, F Anthony Greco
BACKGROUND: The best treatment for patients with advanced non-small cell lung cancer (NSCLC) and a poor performance status is not well defined. In this phase 2 trial, patients were randomized to receive treatment with either single-agent pemetrexed or 1 of 2 combination regimens. METHODS: Patients with newly diagnosed, histologically confirmed nonsquamous NSCLC and an Eastern Cooperative Oncology Group (ECOG) performance status of 2 were stratified by age and serum albumin level and were randomized (1:1:1) to 1 of 3 regimens: pemetrexed (arm 1), pemetrexed and bevacizumab (arm 2), or pemetrexed, carboplatin, and bevacizumab (arm 3)...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29451646/profile-of-patients-with-fournier-s-gangrene-and-their-clinical-evolution
#20
Djoney Rafael Dos-Santos, Ulisses Luiz Tasca Roman, André Pereira Westphalen, Keli Lovison, Fernando Antonio C Spencer Neto
OBJECTIVE: to analyze the profile of patients with Fournier's gangrene treated in a public tertiary hospital in western Paraná State. METHODS: we conducted a cross-sectional, retrospective and descriptive study of patients with Fournier's gangrene treated between January 2012 and November 2016. RESULTS: there were 40 patients with Fournier's gangrene treated in the period, 29 (72.5%) men and 11 (27.5%) women. The mean age was 51.7±16.3 years...
2018: Revista do Colégio Brasileiro de Cirurgiões
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