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https://www.readbyqxmd.com/read/29684933/-dysphagia-from-a-gastroenterologist-s-perspective
#1
Marcus Hollenbach, Jürgen Feisthammel, Joachim Mössner, Albrecht Hoffmeister
Swallowing disorders (dysphagia) comprise a common cause of medical consultation and are defined as a subjective sensation of difficulty or abnormality of swallowing. In the initial step, a clear differentiation of dysphagia from odynophagia and globus sensation for further diagnostic procedures is mandatory. The careful questioning of patients symptoms and complaints is often helpful for the differentiation of oropharyngeal and esophageal dysphagia. Oropharyngeal dysphagia is mainly caused by neurological disorders (cerebral ischemia, Parkinson's disease, dementia) or local compression of malignancies, thyroid gland or lymph nodes...
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29684579/age-and-gender-associations-with-systemic-corticosteroid-induced-morbidity-in-asthma
#2
Luke E Barry, Ciaran O'Neill, Chris Patterson, Joan Sweeney, David Price, Liam G Heaney
BACKGROUND: Treatment of severe asthma may include high dose systemic-corticosteroid therapy which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, gender and corticosteroid exposure levels. OBJECTIVE: Examine the associations between age, gender, comorbidity, and patterns of healthcare cost across groups differentiated by corticosteroid exposure. METHODS: Patients with severe asthma (n=808) were matched by age and gender to patients with mild/moderate asthma (n=3,975) and non-asthma control subjects (n=2,412) from the Optimum Patient Care Research Database (OPCRD)...
April 20, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29684518/long-term-outcomes-after-encephaloduroarteriosynangiosis-in-adult-patients-with-moyamoya-disease-presenting-with-ischemia
#3
Xiang-Yang Bao, Yong Zhang, Qian-Nan Wang, Qian Zhang, Hui-Wang, Zheng-Shan Zhang, De-Sheng Li, Lian Duan
BACKGROUND: In adult Moyamoya disease(MMD), there remains controversy about the effectiveness of revascularization surgeries because randomized studies have not been performed to compare the efficacy of surgical techniques. OBJECT: There is an ongoing controversy regarding the most appropriate surgical treatment for adult patients with MMD. METHODS: Encephaloduroarteriosynangiosis (EDAS) was performed on 247 hemispheres in 145 patients. The clinical and demographic characteristics of patients were obtained via retrospective chart review...
April 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29684209/drug-review-pazopanib
#4
Shingo Miyamoto, Shigenori Kakutani, Yujiro Sato, Akira Hanashi, Yoshitaka Kinoshita, Akira Ishikawa
Pazopanib (Votrient®) is an oral small-molecule multi-kinase inhibitor that primarily inhibits vascular endothelial growth factor receptor-1, -2 and -3, platelet endothelial growth factor receptor-α, and -β, and the stem-cell factor receptor c-kit. In preliminary experiments using angiogenesis models with mice and rabbits, pazopanib inhibited angiogenesis caused by combined vascular endothelial growth factor and basic fibroblast growth factor. Although pazopanib was developed as a therapeutic agent against various tumors, it is currently approved in many countries for advanced soft-tissue sarcoma and renal cell carcinoma...
April 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29684105/aortic-pulse-pressure-does-not-adequately-index-cardiovascular-risk-factor-related-changes-in-aortic-stiffness-and-forward-wave-pressure
#5
Tshegofatso H Motau, Gavin R Norton, Pinhas Sareli, Angela J Woodiwiss
Background: Through the impact of conventional risk factors on arteries, several changes in aortic function contribute to cardiovascular events. It is nevertheless uncertain whether these effects are accurately reflected by changes in central aortic pulse pressure (PPc). We therefore aimed to determine the extent to which relations between modifiable risk factors and aortic function translate into increases in PPc. Methods: In 1232 black South Africans from the South West Township (SOWETO) of Johannesburg, we determined risk factors and aortic function from carotid-femoral pulse wave velocity (PWV) and aortic PPc, forward (Pf) and reflected (backward-Pb) wave pressures (applanation tonometry and SphygmoCor software)...
April 19, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29684077/medication-burden-attributable-to-chronic-co-morbid-conditions-in-the-very-old-and-vulnerable
#6
Kelly L Moore, Kanan Patel, W John Boscardin, Michael A Steinman, Christine Ritchie, Janice B Schwartz
OBJECTIVE: Polypharmacy is common in older patients but relationships between polypharmacy and common co-morbid conditions have not been elucidated. Our goal was to determine relationships between daily oral medication use and common co-morbid disease dyads and triads using comprehensive medication and diagnostic data from a national sample of nursing homes (NH). DESIGN: Retrospective, cross-sectional study. SETTING: Nationally representative sample of U...
2018: PloS One
https://www.readbyqxmd.com/read/29683540/blood-pressure-levels-in-the-acute-phase-after-intracerebral-haemorrhage-are-associated-with-mortality-in-young-adults
#7
Satu Mustanoja, Jukka Putaala, Riku-Jaakko Koivunen, Ida Surakka, Turgut Tatlisumak
BACKGROUND: Blood pressure (BP) levels in acute Intracerebral haemorrhage (ICH) and mortality have not been thoroughly studied in the young. METHODS: The relationship between BP and mortality was assessed in consecutive first-ever, non-traumatic acute ICH patients ≤50 years of age, enrolled in the Helsinki ICH Young Study. BP parameters included systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (SBP-DBP) at admission and 24 hours, and delta (admission-24 hour) BP parameters...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29683445/assessing-collagen-and-elastin-pressure-dependent-microarchitectures-in-live-human-resistance-arteries-by-label-free-fluorescence-microscopy
#8
Maria Bloksgaard, Bjarne Thorsted, Jonathan R Brewer, Jo G R De Mey
The pathogenic contribution of resistance artery remodeling is documented in essential hypertension, diabetes and the metabolic syndrome. Investigations and development of microstructurally motivated mathematical models for understanding the mechanical properties of human resistance arteries in health and disease have the potential to aid understanding how disease and medical treatments affect the human microcirculation. To develop these mathematical models, it is essential to decipher the relationship between the mechanical and microarchitectural properties of the microvascular wall...
April 9, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683305/maternity-care-update-preconception-care
#9
Andrew Smith, Wendy B Barr, Erin Bassett-Novoa, Nicholas LeFevre
Family physicians are in a unique position to ensure that women receive preconception care. The Centers for Disease Control and Prevention, the American College of Obstetricians and Gynecologists, and the American Academy of Family Physicians recommend preconception care for all women, but particularly for women with comorbid conditions such as obesity, diabetes, and chronic hypertension. Family physicians should ask all women of reproductive age who are at risk of unintended pregnancy if they desire pregnancy within the next year and, based on this answer, provide counseling on contraception or preconception care...
April 2018: FP Essentials
https://www.readbyqxmd.com/read/29682125/two-cases-of-micro-arteriovenous-fistula-in-the-lower-extremity-with-misdiagnosis-of-refractory-cellulitis
#10
Miyako Tanaka, Fukashi Serizawa, Yohei Nagaoka, Takuya Jimbo, Kazuki Kawashima, Takeshi Asakura, Hiroshi Otomo, Kenichi Yokota
We report our experience of two cases of refractory cellulitis caused by peripheral micro-arteriovenous fistulas (AVFs) in the lower extremity. The micro-AVFs were so small that they could not be located accurately; further, the patients' symptoms differed markedly from those previously reported for AVF. AVF is known to cause ischemic symptoms. In contrast, micro-AVF causes congestive symptoms and remains undetected in the majority of patients. Identification of this pathology is crucial to enable effective treatment by the ligation of the incompetent perforator vein that increases venous hypertension, leading to congestive symptoms...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681984/effects-of-xin-ji-er-kang-on-anticardiovascular-remodeling-in-l-name-induced-hypertensive-mice-and-its-potential-mechanisms
#11
Li Wang, Guo-Wei Cai, Ling Ding, Juan Hu, Yong-Xue Zhang, Guang-Yao Huang, Pan Cheng, Shan Gao
Background: Xin-Ji-Er-Kang (XJEK) shows protective effects on the myocardial ischemic diseases in our previous reports. We hypothesized that XJEK may exert preventing effects on L -NAME induced hypertensive mice by ameliorating oxidative stress (OS) and endothelial dysfunction (ED). Methods: After treatment with XJEK for four weeks, cardiac function and cardiovascular pathology changes were evaluated. Then, endothelial-dependent vascular relaxation and serum NO, eNOS, AMDA, SOD, MDA content, and cardiac tissue eNOS expression were detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681957/mechanical-circulatory-support-is-effective-to-treat-pulmonary-hypertension-in-heart-transplant-candidates-disqualified-due-to-unacceptable-pulmonary-vascular-resistance
#12
Michał Zakliczyński, Jerzy Pacholewicz, Izabela Copik, Marcin Maruszewski, Tomasz Hrapkowicz, Roman Przybylski, Marian Zembala
Introduction: High pulmonary vascular resistance (PVR) in orthotopic heart transplantation (OHT) candidates is a risk factor of right ventricle failure after the procedure. However, the increase of PVR may be a consequence of the life-threatening deterioration of the left ventricle function. The use of mechanical circulatory support (MCS) seems to be the best solution, but it is reimbursed only in active OHT candidates. Aim: We performed a retrospective analysis of MCS effectiveness in maintaining PVR at values accepted for OHT...
March 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29681616/progress-in-preventive-therapy-for-cancer-a-reminiscence-and-personal-viewpoint
#13
REVIEW
Jack Cuzick
Prophylactic drug treatment with aspirin, statins and anti-hypertensive agents has had a major impact on the incidence of cardiovascular disease and is now well established. Progress in therapeutic cancer prevention has been much slower; only recently have effective agents been clearly established. Breast cancer has led the way and endocrine agents used to treat it-notably tamoxifen and the aromatase inhibitors-have now been shown to have a substantial preventive effect as well. However, these agents carry some toxicity and thus identifying high-risk women who are likely to benefit most is a key priority...
April 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29680851/lichenoid-lesions-of-the-upper-lip-a-retrospective-study-of-24-cases
#14
N Katsoulas, K Tosios, A Sklavounou-Andrikopoulou
BACKGROUND: Lichenoid lesions of the upper labial mucosa, without other oral or extraoral manifestations seem to be rare. The clinicopathologic features of 24 such cases are presented and the pertinent literature is reviewed. MATERIALS AND METHODS: 24 Caucasian patients that clinically presented lichenoid features on the upper labial mucosa, with or without lichenoid lesions on the adjacent gingiva, were included in the study. Clinical features were extracted from the patients records, while dental plaque/calculus accumulation and composite resin restorations of the adjacent teeth were recorded...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680418/uvulopalatopharyngoplasty-reduces-the-incidence-of-cardiovascular-complications-caused-by-obstructive-sleep-apnea-results-from-the-national-insurance-service-survey-2007-2014
#15
Heung Man Lee, Hyo Yeol Kim, Jeffrey D Suh, Kyung-Do Han, Jin Kook Kim, Young Chang Lim, Seok-Chan Hong, Jae Hoon Cho
OBJECTIVE: Untreated obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease including myocardial infarction (MI), congestive heart failure (CHF), and atrial fibrillation (AF). Continuous positive airway pressure (CPAP) is an effective treatment for OSA; however, compliance with CPAP can be challenging for some patients. The objective of this study was to investigate whether uvulopalatopharyngoplasty (UPPP) reduced the risk of cardiovascular complications for patients with OSA...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680416/electrocardiographic-variables-in-children-with-syndromic-craniosynostosis-and-primary-snoring-to-mild-obstructive-sleep-apnea-significance-of-identifying-respiratory-arrhythmia-during-sleep
#16
Ellaha Kakar, Linda J A Corel, Robert C Tasker, Robbin de Goederen, Eppo B Wolvius, Irene M J Mathijssen, Koen F M Joosten
BACKGROUND: In the spectrum of children with symptomatic sleep disordered breathing (SDB), some individuals - such as those with upper airway resistance syndrome (UARS) - do not have abnormalities on polysomnography (PSG). In this study we have assessed whether assessment of respiratory arrhythmia (RA) and heart rate variability (HRV) analysis helps in management of children with syndromic craniosynostosis and none-to-mild obstructive sleep apnea (OSA). METHODS: Prospective cohort study in children aged 1-18 years old with syndromic craniosynostosis...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680341/pulmonary-hypertension-in-patients-with-severe-aortic-stenosis-prognostic-impact-after-transcatheter-aortic-valve-replacement-pulmonary-hypertension-in-patients-undergoing-tavr
#17
Brunilda Alushi, Frederik Beckhoff, David Leistner, Marcus Franz, Markus Reinthaler, Barbara E Stähli, Andreas Morguet, Hans R Figulla, Torsten Doenst, Francesco Maisano, Volkmar Falk, Ulf Landmesser, Alexander Lauten
OBJECTIVES: The authors investigated the development of pulmonary hypertension (PH), predictors of PH regression, and its prognostic impact on short, mid-, and long-term outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). BACKGROUND: PH represents a common finding in patients with AS. Although TAVR is frequently associated with regression of PH, the predictors of reversible PH and its prognostic significance remain uncertain...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680240/peptide-derivatives-of-erythropoietin-in-the-treatment-of-neuroinflammation-and-neurodegeneration
#18
Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc, Kursad Genc
During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue protective effect of EPO could not be translated to the clinical trials because of common lethal thromboembolic events, erythropoiesis and hypertension...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29679752/thermodynamic-compatibility-between-cyclodextrin-supramolecular-complexes-and-surfactant
#19
Larissa H R Meira, Guilherme A B Soares, Homero I M Bonomini, Juliana Fedoce Lopes, Frederico B De Sousa
Supramolecular structures based on cyclodextrins have been extensively used for drug delivery systems over decades. However, combining host and guest molecules in a pharmaceutical formulation is not a trivial process, being one of the majors concern the inclusion complex compatibility with other excipients presented in the final formulation. Herein, experimental and theoretical calculations were used to investigate the competition of sodium dodecyl sulfate (SDS) with atenolol (ATE) or losartan (LOS), antihypertensive drugs widely used in the treatment of hypertension...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29679599/mortality-in-pulmonary-arterial-hypertension-patients-treated-with-continuous-prostanoids
#20
S D Bartolome, N Sood, T S Shah, K Styrvoky, F T Torres, K M Chin
INTRODUCTION: Parenteral prostanoids are considered the treatment of choice for patients with severe pulmonary arterial hypertension (PAH). Prognostic studies for patients treated in the modern era are limited. METHODS: In this retrospective cohort study, patients initiating IV epoprostenol or IV or SC treprostinil therapy for PAH from 2007-2016 at UT Southwestern, Dallas, TX and Ohio State University, Columbus, OH were included. Transplant-free survival was assessed from the time of IV/SC initiation and from the time of first follow-up...
April 18, 2018: Chest
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