keyword
MENU ▼
Read by QxMD icon Read
search

Er positive

keyword
https://www.readbyqxmd.com/read/28239379/estrogen-receptor-dependent-regulation-of-dendritic-cell-development-and-function
#1
REVIEW
Sophie Laffont, Cyril Seillet, Jean-Charles Guéry
Autoimmunity, infectious diseases and cancer affect women and men differently. Because they tend to develop more vigorous adaptive immune responses than men, women are less susceptible to some infectious diseases but also at higher risk of autoimmunity. The regulation of immune responses by sex-dependent factors probably involves several non-redundant mechanisms. A privileged area of study, however, concerns the role of sex steroid hormones in the biology of innate immune cells, especially dendritic cells (DCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28238747/role-of-c-ebp-homologous-protein-chop-and-endoplasmic-reticulum-in-asthma-exacerbation-by-regulating-the-il-4-stat6-tfec-il-4r%C3%AE-positive-feedback-loop-in-m2-macrophages
#2
Yi Wang, Jianghui Zhu, Lei Zhang, Zhijun Zhang, Long He, Yong Mou, Yanhan Deng, Yong Cao, Ping Yang, Yunchao Su, Jianping Zhao, Shu Zhang, Qilin Yu, Jifa Hu, Zhishui Chen, Qin Ning, Xudong Xiang, Yongjian Xu, Cong-Yi Wang, Weining Xiong
BACKGROUND: C/EBP homologous protein (CHOP), a marker of endoplasmic reticulum (ER) stress, exhibits aberrant expression patterns during the development of asthma. However, its exact role in asthma pathogenesis is not fully understood. OBJECTIVES: We aimed to determine the function and mechanism of CHOP in the pathogenesis of allergic asthma in patients and animals. METHODS: Studies were conducted in asthmatic patients and CHOP(-/-) mice to dissect the role of CHOP and ER stress in asthma pathogenesis...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28237486/targeted-inhibition-of-notch1-gene-enhances-the-killing-effects-of-paclitaxel-on-triple-negative-breast-cancer-cells
#3
Yu-Fu Zhou, Qian Sun, Ya-Jun Zhang, Geng-Ming Wang, Bin He, Tao Qi, Yan Zhou, Xing-Wang Li, Sheng Li, Lin He
OBJECTIVE: To study the influence of targeted inhibition of Notch1 gene on the killing effects of paclitaxel on triple negative breast cancer cells. METHODS: The triple negative [estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (Her2)] breast cancer cell line MDA-MB-231 and ER/PR/HER-2-positive breast cancer cell line MCF-7 were cultured, transfected with Notch1-siRNA-overexpression plasmid and blank plasmid, and treated with different concentrations of paclitaxel, and then the cell proliferation activity and apoptosis rate as well as the mRNA expression of Caspase-3, Caspase-9 and Bcl-2 were determined...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28236153/expression-of-stromal-caveolin-1-may-be-a-predictor-for-aggressive-behaviour-of-breast-cancer
#4
Nuket Eliyatkin, Safiye Aktas, Gulden Diniz, Halil Hakan Ozgur, Zubeyde Yildirim Ekin, Ali Kupelioglu
Caveolin-1 (Cav-1) is well known as a principal scaffolding protein of caveolae which are specialized plasma membrane structures. The role of Cav-1 in tumorigenesis of breast cancers is relatively less studied. The aim of the present study is to describe the biological roles of Cav-1 in breast cancers considering its contrasting dual functions as an oncogene and as a tumor suppressor. This study included 71 females with breast cancer who had been histopathologically diagnosed in Private Gunes Pathology Laboratory between the years 2007, and 2012...
February 24, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28231489/moving-and-positioning-the-endolysosomal-system
#5
REVIEW
Juan S Bonifacino, Jacques Neefjes
The endolysosomal system is extremely dynamic, yet highly organized. The spatio-temporal distribution of endolysosomal organelles depends on transport driven by microtubule motors such as kinesins and dynein, and by actin-based myosin motors. It has recently become appreciated that interactions with motors are controlled by contacts with other organelles, particularly the endoplasmic reticulum (ER). The ER also controls the concentration of endolysosomal organelles in the perinuclear area, as well as their fission and fusion, through a complex system of tethering proteins...
February 20, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28229344/variation-in-risk-and-outcomes-of-epstein-barr-virus-associated-breast-cancer-by-epidemiologic-characteristics-and-virus-detection-strategies-an-exploratory-study
#6
Sally L Glaser, Alison J Canchola, Theresa H M Keegan, Christina A Clarke, Teri A Longacre, Margaret L Gulley
PURPOSE: A relationship of Epstein-Barr virus (EBV) and breast cancer etiology and outcome may have clinical utility and potential to enhance understanding of tumor biology. Research to date has yielded variable results, likely reflecting differing virus detection assays and unaddressed epidemiologic heterogeneity across studies. METHODS: Applying our novel, five-target assay detection strategy in an exploratory study, we examined demographic, clinical, and tumor characteristics, and overall survival, associated with EBV positivity in breast adenocarcinomas from 59 non-Hispanic white and 68 Hispanic women sampled by age (<50, 50+) and stage (localized, regional/remote) and examined associations based on single assay targets...
February 22, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28225525/effects-of-game-performance-on-softball-pitchers-and-catchers
#7
Gretchen D Oliver, Hillary A Plummer, Jessie Washington, Wendi H Weimar, Allison Brambeck
The purpose of this study was to examine the effects of game exposure on pitchers and catchers' hip and glenohumeral range of motion (ROM), isometric strength, and vertical jump performance and power. Five college female softball pitchers (174.24 ± 7.53 cm; 82.10 ± 11.27 kg; 20 ± 1.82 years) and four catchers (165.10 ± 9.04 kg; 68.61 ± 3.87 cm; 20 ± 1.41 years) participated. Hip and glenohumeral rotational ROM; hip and glenohumeral rotational isometric strength; hip abduction and adduction strength; and vertical jump height were assessed pre and post-game exposure...
February 21, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28223864/clinical-pharmacist-interventions-in-refill-clinic-at-tertiary-care-eye-specialist-hospital
#8
Sitah N Alzuman, Abdullah S Al-Humaidan
Objective: To describe the role of Clinical Pharmacists in the Medication Refill Clinic area as a part of a multidisciplinary team in which he/she can provide education to patients and caregivers on the safe and appropriate use of medications, counsel on medication compliance, monitor and manage medication side effects, as well as screen for dangerous drug interactions. Methods: The data of this prospective, single-centered, chart review based study have been collected since the clinic launched in June 2011 till December 2013 in King Khalid Eye Specialist Hospital which is a Tertiary Hospital in KSA...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28223720/is-endoscopic-ultrasound-examination-necessary-in-the-management-of-esophageal-cancer
#9
REVIEW
Tomas DaVee, Jaffer A Ajani, Jeffrey H Lee
Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound (EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients with early cancers, which appropriately balances the risks and benefits of surgery, chemotherapy and radiation...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28222239/evolutionary-rescue-and-local-adaptation-under-different-rates-of-temperature-increase-a-combined-analysis-of-changes-in-phenotype-expression-and-genotype-frequency-in-paramecium-microcosms
#10
Joshua Killeen, Claire Gougat-Barbera, Sascha Krenek, Oliver Kaltz
Evolutionary Rescue (ER) occurs when populations, which have declined due to rapid environmental change, recover through genetic adaptation. The success of this process and the evolutionary trajectory of the population strongly depend on the rate of environmental change. Here we investigated how different rates of temperature increase (from 23°C to 32°C) affect population persistence and evolutionary change in experimental microcosms of the protozoan Paramecium caudatum. Consistent with theory on ER, we found that those populations experiencing the slowest rate of temperature increase were the least likely to become extinct and tended to be the best adapted to the new temperature environment...
February 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28222072/discrepancies-in-central-review-re-testing-of-patients-with-er-positive-and-her2-negative-breast-cancer-in-the-optima-prelim-randomised-clinical-trial
#11
S E Pinder, A F Campbell, J M S Bartlett, A Marshall, D Allen, M Falzon, J A Dunn, A Makris, L Hughes-Davies, R C Stein
BACKGROUND: There is limited data on results of central re-testing of samples from patients with invasive breast cancer categorised in their local hospital laboratories as oestrogen receptor (ER) positive and human epidermal growth factor receptor homologue 2 (HER2) negative. METHODS: The Optimal Personalised Treatment of early breast cancer usIng Multiparameter Analysis preliminary study (OPTIMA prelim) was the feasibility phase of a randomised controlled trial to validate the use of multiparameter assay-directed chemotherapy decisions in the UK National Health Service (NHS)...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28221191/the-assessment-of-estrogen-receptor-status-and-its-intratumoral-heterogeneity-in-breast-cancer-patients-by-using-18-f-fluoroestradiol-pet-ct
#12
Zhongyi Yang, Yifei Sun, Xiaoping Xu, Yongping Zhang, Jianping Zhang, Jing Xue, Mingwei Wang, Huiyu Yuan, Silong Hu, Wei Shi, Beiling Zhu, Yingjian Zhang
AIM: The aim of this study was to investigate the clinical value of F-fluoroestradiol (F-FES) PET/CT in the assessment of the estrogen receptor (ER) and its intratumoral heterogeneity in breast cancer patients. METHODS: Forty-six female patients (50 lesions) with histologically confirmed invasive breast cancer who underwent both F-FES and F-FDG PET/CT in our center were retrospectively included. All the patients enrolled were scheduled to undergo biopsy. The F-FES and FDG uptakes were compared with pathological features (tumor size, ER, progesterone receptor, human epidermal growth factor receptor 2, and Ki67%)...
February 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28220843/dusp1-promoter-methylation-in-peripheral-blood-leukocyte-is-associated-with-triple-negative-breast-cancer-risk
#13
Jing Li, Yanbo Chen, Hongyuan Yu, Jingshen Tian, Fengshun Yuan, Jialong Fan, Yupeng Liu, Lin Zhu, Fan Wang, Yashuang Zhao, Da Pang
DNA methylation is one of the most common epigenetic alterations, providing important information regarding cancer risk and prognosis. A case-control study (423 breast cancer cases, 509 controls) and a case-only study (326 cases) were conducted to evaluate the association of DUSP1 promoter methylation with breast cancer risk and clinicopathological characteristics. No significant association between DUSP1 methylation in peripheral blood leukocyte (PBL) DNA and breast cancer risk was observed. DUSP1 methylation was significantly associated with ER/PR-negative status; in particular, triple-negative breast cancer patients showed the highest frequency of DUSP1 methylation in both tumour DNA and PBL DNA...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220142/absence-of-an-n-linked-glycosylation-motif-in-the-glycoprotein-of-the-live-attenuated-argentine-hemorrhagic-fever-vaccine-candid-1-results-in-its-improper-processing-and-reduced-surface-expression
#14
John T Manning, Alexey V Seregin, Nadezhda E Yun, Takaaki Koma, Cheng Huang, José Barral, Juan C de la Torre, Slobodan Paessler
Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the Can glycoprotein (GPC) gene is the primary gene responsible for attenuation in a guinea pig model of AHF. However, the mechanisms through which the GPC contributes to the attenuation of the Can strain remain unknown. A more complete understanding of the mechanisms underlying the attenuation and immunogenicity of the Can strain will potentially allow for the rational design of additional safe and novel vaccines...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28220099/suppression-benefits-boys-in-taiwan-the-relation-between-gender-emotional-regulation-strategy-and-mental-health
#15
Kuang-Hui Yeh, Olwen Bedford, Chih-Wen Wu, Shu-Yi Wang, Nai-Shing Yen
Emotion regulation (ER) strategies have a clear impact on mental health outcomes. In 2 studies (N = 695, N = 433) we investigated gender differences in the use of 2 ER strategies (reappraisal and suppression) to handle parent-child conflict in Taiwanese adolescents. We also identified the implications of these differences for some negative emotions (self-blame and resentment) and internalizing problems (psychosomatic symptoms and social withdrawal). Results of the correlation analyses in both studies indicated that reappraisal and suppression ER strategies are positively correlated only in male Taiwanese adolescents...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28218252/dissecting-the-molecular-organization-of-the-translocon-associated-protein-complex
#16
Stefan Pfeffer, Johanna Dudek, Miroslava Schaffer, Bobby G Ng, Sahradha Albert, Jürgen M Plitzko, Wolfgang Baumeister, Richard Zimmermann, Hudson H Freeze, Benjamin D Engel, Friedrich Förster
In eukaryotic cells, one-third of all proteins must be transported across or inserted into the endoplasmic reticulum (ER) membrane by the ER protein translocon. The translocon-associated protein (TRAP) complex is an integral component of the translocon, assisting the Sec61 protein-conducting channel by regulating signal sequence and transmembrane helix insertion in a substrate-dependent manner. Here we use cryo-electron tomography (CET) to study the structure of the native translocon in evolutionarily divergent organisms and disease-linked TRAP mutant fibroblasts from human patients...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28216163/il-33-facilitates-endocrine-resistance-of-breast-cancer-by-inducing-cancer-stem-cell-properties
#17
Haiyan Hu, Jiaxing Sun, Chunhong Wang, Xiangmao Bu, Xiangping Liu, Yan Mao, Haibo Wang
Breast cancers with estrogen receptor (ER) expressions account for the majority of all clinical cases. Due to hormone therapy with tamoxifen, prognoses of patients with ER-positive breast cancer are significantly improved. However, endocrine resistance to tamoxifen is common and inevitable, leading to compromised efficacy of hormone therapy. Herein, we identify a crucial role of IL-33 in inducing endocrine resistance of breast cancer. IL-33 overexpression in breast cancer cells results in resistance to tamoxifen-induced tumor growth inhibition, while IL-33 knockdown corrects this problem...
February 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28216107/an-endoplasmic-reticulum-engineered-yeast-platform-for-overproduction-of-triterpenoids
#18
Philipp Arendt, Karel Miettinen, Jacob Pollier, Riet De Rycke, Nico Callewaert, Alain Goossens
Saponins are a structurally diverse family of triterpenes that are widely found as main constituents in many traditional plant-based medicines and often have bioactivities of industrial interest. The heterologous production of triterpene saponins in microbes remains challenging and only limited successful pathway engineering endeavors have been reported. To improve the production capacities of a Saccharomyces cerevisiae saponin production platform, we assessed the effects of several hitherto unexplored gene knockout targets on the heterologous production of triterpenoids...
February 16, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28216025/pi3k-akt-mtor-inhibitors-in-breast-cancers-from-tumor-cell-signaling-to-clinical-trials
#19
REVIEW
Dey Nandini, De Pradip, Leyland-Jones Brian
Breast cancer (BC) is the most common women cancer and second most common cause of cancer death in women. A woman living in the United States has 12.3% lifetime risk of being diagnosed with BC. From the genomics point of view, the most common three subtypes of BC encountered in clinics are HR+, HER2+, and TNBC or basal-like BC. Estrogen receptor (ER) status or HER2 amplification or chemotherapy is not sufficient to understand the underlying mechanisms of disease progression and resistance (de novo or acquire)...
February 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28215742/identification-of-grass-carp-ctenopharyngodon-idella-xbp1s-as-a-primary-member-in-er-stress
#20
Xiangqin Wang, Yichuan Mi, Bin Zhong, Huiling Mao, Yiqi Wan, Tao Zhang, Haizhou Wang, Chengyu Hu
X-box binding protein 1 (XBP1), a vital basic leucine zipper transcription factor for the related gene transcription in endoplasmic reticulum (ER) stress, belongs to the CREB/ATF family. In mammals, XBP1S is the activated one of XBP1 isoform. In order to study the role of fish XBP1S, we cloned and identified the XBP1S (KU509247) from grass carp (Ctenopharyngodon idella) (named CiXBP1S) by homologous cloning and RACE technique. The full length of CiXBP1S is 1694 bp along with 124 bp of 5' UTR, 418 bp of 3' UTR and the longest open reading frame (1152 bp) encoding a polypeptide of 383 amino acids with a well conserved DNA binding domain (BRLZ domain)...
February 16, 2017: Fish & Shellfish Immunology
keyword
keyword
88065
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"