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https://www.readbyqxmd.com/read/28934023/biomarker-enrichment-considerations-in-oncology-early-development-single-arm-studies
#1
Hong Tian, Kevin Liu
Oncology drug development has been increasingly shaped by molecularly targeted agents (MTAs), which often demonstrate differential effectiveness driven by the biomarker expression levels on tumors. Innovative statistical designs have been proposed to tackle this challenge, e.g., Freidlin et al (2005), Jiang et al (2007) and Freidlin et al (2010). All of these are essentially adaptive confirmatory Phase 3 designs that combine the testing of treatment effectiveness in the overall population with an alternative pathway for a more restrictive efficacy claim in a sensitive subpopulation...
September 21, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28929022/development-and-evaluation-of-rapid-novel-isothermal-amplification-assays-for-important-veterinary-pathogens-chlamydia-psittaci-and-chlamydia-pecorum
#2
Martina Jelocnik, Md Mominul Islam, Danielle Madden, Cheryl Jenkins, James Branley, Scott Carver, Adam Polkinghorne
BACKGROUND: Chlamydia psittaci and Chlamydia pecorum are important veterinary pathogens, with the former also being responsible for zoonoses, and the latter adversely affecting koala populations in Australia and livestock globally. The rapid detection of these organisms is still challenging, particularly at the point-of-care (POC). In the present study, we developed and evaluated rapid, sensitive and robust C. psittaci-specific and C. pecorum-specific Loop Mediated Isothermal Amplification (LAMP) assays for detection of these pathogens...
2017: PeerJ
https://www.readbyqxmd.com/read/28926809/spatial-distribution-of-glomalin-related-soil-protein-and-its-relationship-with-sediment-carbon-sequestration-across-a-mangrove-forest
#3
Qiang Wang, Haoliang Lu, Jingyan Chen, Hualong Hong, Jingchun Liu, Junwei Li, Chongling Yan
Arbuscular mycorrhizal (AM) fungi produce a recalcitrant glycoprotein, (glomalin-related soil protein (GRSP)), which can contribute to soil carbon sequestration. Here we made a first study to characterize the spatial distribution of GRSP fractions in a mangrove forest at Zhangjiang Estuary, Southeastern China and to explore potential contributions of GRSP to sediment organic carbon (SOC) in this forest. We identified GRSP fractions in surface sediments, as well as those at a depth of 50 cm. The contents of easily extractable GRSP (EE-GRSP), total GRSP (T-GRSP), GRSP in particulate organic matter (POM-GRSP) and GRSP in pore water (PW-GRSP) ranged between 1...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28925968/recent-progress-in-the-development-of-diagnostic-tests-for-malaria
#4
REVIEW
Francis D Krampa, Yaw Aniweh, Gordon A Awandare, Prosper Kanyong
The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains...
September 19, 2017: Diagnostics
https://www.readbyqxmd.com/read/28923817/patient-willingness-to-have-tests-to-guide-antibiotic-use-for-respiratory-tract-infections-from-the-wwami-region-practice-and-research-network-wprn
#5
Malaika Schwartz, Victoria Hardy, Gina A Keppel, William Alto, Jaime Hornecker, Beth Robitaille, Jon Neher, John Holmes, M Ashworth Dirac, Allison M Cole, Matthew Thompson
INTRODUCTION: The majority of consultations for acute respiratory tract infections (RTIs) lead to prescriptions for antibiotics, which have limited clinical benefit. We explored patients' willingness to have blood tests as part of the diagnostic work-up for RTIs, and patient knowledge about antibiotics. METHODS: Patients at 6 family medicine clinics were surveyed. Regression modeling was used to determine independent predictors of willingness to have venous and point-of-care (POC) blood tests, and knowledge of the value of antibiotics for RTIs...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28922391/impedance-biosensor-for-real-time-monitoring-and-prediction-of-thrombotic-individual-profile-in-flowing-blood
#6
Denise De Zanet, Monica Battiston, Elisabetta Lombardi, Ruben Specogna, Francesco Trevisan, Luigi De Marco, Antonio Affanni, Mario Mazzucato
A new biosensor for the real-time analysis of thrombus formation is reported. The fast and accurate monitoring of the individual thrombotic risk represents a challenge in cardiovascular diagnostics and in treatment of hemostatic diseases. Thrombus volume, as representative index of the related thrombotic status, is usually estimated with confocal microscope at the end of each in vitro experiment, without providing a useful behavioral information of the biological sample such as platelets adhesion and aggregation in flowing blood...
2017: PloS One
https://www.readbyqxmd.com/read/28918967/accuracy-of-bedside-point-of-care-testing-in-critical-emergency-department-patients
#7
Braden W McIntosh, Jerina Vasek, Maria Taylor, Deborah Le Blanc, Henry C Thode, Adam J Singer
BACKGROUND: Point-of-care (POC) testing reduces laboratory turn-around having the potential to improve timely diagnosis and management. We compared the accuracy of nurse performed POC and core laboratory testing and determined whether deviations between the two were clinically meaningful. METHODS: We performed a prospective, observational study on a convenience sample of 50 critical care ED patients in whom a POC chemistry and hematocrit was ordered. Blood samples were divided into 2 aliquots; one sample was tested by the treating nurse using a handheld POC device and the other sample was tested in the core laboratory...
September 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28917909/development-of-poly-1-8-octanediol-citrate-chitosan-blend-films-for-tissue-engineering-applications
#8
Ehsan Zeimaran, Sara Pourshahrestani, Belinda Pingguan-Murphy, Daniel Kong, Sangeetha Vasudevaraj Naveen, Tunku Kamarul, Nahrizul Adib Kadri
Blends of poly (1, 8-octanediol citrate) (POC) and chitosan (CS) were prepared through solution casting technique. Films with different component fractions (POC/CS: 100/0, 90/10, 80/20, 70/30, 60/40, and 0/100) were successfully prepared and characterized for their mechanical, thermal, structural and morphological properties as well as biocompatibility. The incorporation of CS to POC significantly increased tensile strength and elastic modulus and presented limited influences on pH variation which is important to the biocompatibility of biomaterial implants...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28906279/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-antiretroviral-therapy-monitoring-strategies-to-resource-limitations
#9
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load monitoring compared with current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the Cost-Effectiveness of Preventing AIDS Complications-International model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio [$/year of life saved (YLS)] of ART monitoring strategies in Mozambique...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28902042/performance-of-a-quick-pregnancy-test-on-whole-blood-in-early-pregnancy-units-a-prospective-cohort-study
#10
Caroline Legoupil, Isabelle Enderle, Flore-Anne Le Baccon, Claude Bendavid, Lucas Peltier, Estelle Bauville, Jean Leveque, Vincent Lavoue, Maela Le Lous
OBJECTIVE: To assess the diagnostic performance of the NG-Test human chorionic gonadotropin (hCG) WB, which is a new point-of-care (POC) hCG whole-blood test. MATERIALS AND METHODS: This prospective study included women consulted in early pregnancy units for vaginal bleeding and/or pelvic pain with unknown pregnancy status after medical consultation including a pelvic ultrasound scan. A new POC test (the NG-Test hCG WB) and the usual laboratory serum test (considered the gold standard) were performed in patients...
September 8, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28895084/the-oncologic-impact-of-postoperative-complications-following-resection-of-truncal-and-extremity-soft-tissue-sarcomas
#11
Justine S Broecker, Cecilia G Ethun, David K Monson, Alexandra G Lopez-Aguiar, Nina Le, Mia McInnis, Karen Godette, Nickolas B Reimer, Shervin V Oskouei, Keith A Delman, Charles A Staley, Shishir K Maithel, Kenneth Cardona
INTRODUCTION: Postoperative complications (POCs) negatively impact oncologic outcomes in some malignancies; however, little is known regarding their effect in soft tissue sarcoma (STS). The aim of this study was to determine the impact of POCs on survival after resection of truncal and extremity STS. METHODS: All patients who underwent resection for a primary truncal or extremity STS at a single academic institution from 2000 to 2015 were included and analyzed. Primary outcome was disease-specific survival (DSS)...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28894467/racial-and-socioeconomic-disparities-are-more-pronounced-in-inflammatory-breast-cancer-than-other-breast-cancers
#12
Ryan A Denu, John M Hampton, Adam Currey, Roger T Anderson, Rosemary D Cress, Steven T Fleming, Joseph Lipscomb, Xiao-Cheng Wu, J Frank Wilson, Amy Trentham-Dietz
Inflammatory breast cancer (IBC) is a rare yet aggressive form of breast cancer. We examined differences in patient demographics and outcomes in IBC compared to locally advanced breast cancer (LABC) and all other breast cancer patients from the Breast and Prostate Cancer Data Quality and Patterns of Care Study (POC-BP), containing information from cancer registries in seven states. Out of 7,624 cases of invasive carcinoma, IBC and LABC accounted for 2.2% (N = 170) and 4.9% (N = 375), respectively. IBC patients were more likely to have a higher number (P = 0...
2017: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/28893316/intraosseous-blood-samples-for-point-of-care-analysis-agreement-between-intraosseous-and-arterial-analyses
#13
Milla Jousi, Simo Saikko, Jouni Nurmi
BACKGROUND: Point-of-care (POC) testing is highly useful when treating critically ill patients. In case of difficult vascular access, the intraosseous (IO) route is commonly used, and blood is aspirated to confirm the correct position of the IO-needle. Thus, IO blood samples could be easily accessed for POC analyses in emergency situations. The aim of this study was to determine whether IO values agree sufficiently with arterial values to be used for clinical decision making. METHODS: Two samples of IO blood were drawn from 31 healthy volunteers and compared with arterial samples...
September 11, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28893237/methods-for-the-field-evaluation-of-quantitative-g6pd-diagnostics-a-review
#14
REVIEW
Benedikt Ley, Germana Bancone, Lorenz von Seidlein, Kamala Thriemer, Jack S Richards, Gonzalo J Domingo, Ric N Price
Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at risk of severe haemolysis following the administration of 8-aminoquinoline compounds. Primaquine is the only widely available 8-aminoquinoline for the radical cure of Plasmodium vivax. Tafenoquine is under development with the potential to simplify treatment regimens, but point-of-care (PoC) tests will be needed to provide quantitative measurement of G6PD activity prior to its administration. There is currently a lack of appropriate G6PD PoC tests, but a number of new tests are in development and are likely to enter the market in the coming years...
September 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28891412/a-novel-prothrombin-time-method-to-measure-all-non-vitamin-k-dependent-oral-anticoagulants-noacs
#15
Tomas L Lindahl, Kerstin Arbring, Maria Wallstedt, Mats Rånby
BACKGROUND: There is a clinical need for point-of-care (POC) methods for non-vitamin K-dependent oral anticoagulants (NOACs). We modified a routine POC procedure: Zafena's Simple Simon™ PT-INR, a room-temperature, wet-chemistry prothrombin time method of the Owren-type. METHODS: To either increase or decrease NOAC interference, two assay variants were devised by replacing the standard 10 µL end-to-end capillary used to add the citrated plasma sample to 200 µL of prothrombin time (PT) reagent by either a 20 µL or a 5 µL capillary...
September 11, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28890227/using-the-transtheoretical-model-to-predict-physical-activity-level-of-overweight-adults-with-serious-mental-illness
#16
Ahmed Jérôme Romain, Amal Abdel-Baki
Although physical activity (PA) is recommended for individuals with serious mental illness (ISMI), most of them are inactive or insufficiently active. The transtheoretical model (TTM) has been proposed to explain the motivational factors associated with PA however, there is little evidence of its applicability to ISMI. So, the objective was to analyse whether TTM components are related to PA in overweight ISMI. In this cross-sectional study, participants completed the Global Physical Activity Questionnaire to assess their PA level and TTM components: stages of change (SOC), decisional balance (pros and cons), self-efficacy and processes of change (POC; experiential and behavioural)...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28885551/design-and-validation-of-a-150-mhz-hffqcm-sensor-for-bio-sensing-applications
#17
Román Fernández, Pablo García, María García, José V García, Yolanda Jiménez, Antonio Arnau
Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) platforms. In this work, the design, characterization, and validation of a 150 MHz high fundamental frequency quartz crystal microbalance (HFF-QCM) sensor for bio-sensing applications are introduced. Finite element method (FEM) simulations of the proposed design are in good agreement with the electrical characterization of the manufactured resonators...
September 8, 2017: Sensors
https://www.readbyqxmd.com/read/28883723/comparison-of-pulsed-versus-continuous-oxygen-delivery-using-realistic-adult-nasal-airway-replicas
#18
John Z Chen, Ira M Katz, Marine Pichelin, Kaixian Zhu, Georges Caillibotte, Michelle L Noga, Warren H Finlay, Andrew R Martin
BACKGROUND: Portable oxygen concentrators (POCs) typically include pulse flow (PF) modes to conserve oxygen. The primary aims of this study were to develop a predictive in vitro model for inhaled oxygen delivery using a set of realistic airway replicas, and to compare PF for a commercial POC with steady flow (SF) from a compressed oxygen cylinder. METHODS: Experiments were carried out using a stationary compressed oxygen cylinder, a POC, and 15 adult nasal airway replicas based on airway geometries derived from medical images...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28883465/the-oceanic-biological-pump-rapid-carbon-transfer-to-depth-at-continental-margins-during-winter
#19
Laurenz Thomsen, Jacopo Aguzzi, Corrado Costa, Fabio De Leo, Andrea Ogston, Autun Purser
The oceanic biological pump is responsible for the important transfer of CO2-C as POC "Particulate Organic Carbon" to the deep sea. It plays a decisive role in the Earth's carbon cycle and significant effort is spent to quantify its strength. In this study we used synchronized daily time-series data of surface chlorophyll-a concentrations from the NASA's MODIS satellite in combination with hourly to daily observations from sea surface buoys and from an Internet Operated Vehicle (IOV) on the seafloor within Barkley Canyon (Northeast Pacific) to investigate the importance of winter processes in the export of fresh phytodetritus...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879151/programmatic-implications-of-implementing-the-relational-algebraic-capacitated-location-racl-algorithm-outcomes-on-the-allocation-of-laboratory-sites-test-volumes-platform-distribution-and-space-requirements
#20
Naseem Cassim, Honora Smith, Lindi M Coetzee, Deborah K Glencross
INTRODUCTION: CD4 testing in South Africa is based on an integrated tiered service delivery model that matches testing demand with capacity. The National Health Laboratory Service has predominantly implemented laboratory-based CD4 testing. Coverage gaps, over-/under-capacitation and optimal placement of point-of-care (POC) testing sites need investigation. OBJECTIVES: We assessed the impact of relational algebraic capacitated location (RACL) algorithm outcomes on the allocation of laboratory and POC testing sites...
2017: African Journal of Laboratory Medicine
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