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https://www.readbyqxmd.com/read/29148576/free-breathing-abdominal-mri-improved-by-repeated-k-t-subsampling-and-artifact-minimization-rekam
#1
Mei-Lan Chu, Hing-Chiu Chang, Hsiao-Wen Chung, Mustafa R Bashir, Jing Cai, Lei Zhang, Duohua Sun, Nan-Kuei Chen
PURPOSE: We report an approach, termed Repeated k-t-subsampling and artifact-minimization (ReKAM), for removing motion artifacts in free-breathing abdominal MRI. The method is particularly valuable for challenging patients who may not hold their breath for a long time or have irregular respiratory rate. METHODS: The ReKAM framework comprises one acquisition module and two reconstruction modules. A fast MRI sequence is used to repeatedly acquire multiple sets of k-t space data...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29147848/simultaneous-point-of-care-detection-of-anemia-and-sickle-cell-disease-in-tanzania-the-rapid-study
#2
Luke R Smart, Emmanuela E Ambrose, Kevin C Raphael, Adolfine Hokororo, Erasmus Kamugisha, Erika A Tyburski, Wilbur A Lam, Russell E Ware, Patrick T McGann
Both anemia and sickle cell disease (SCD) are highly prevalent across sub-Saharan Africa, and limited resources exist to diagnose these conditions quickly and accurately. The development of simple, inexpensive, and accurate point-of-care (POC) assays represents an important advance for global hematology, one that could facilitate timely and life-saving medical interventions. In this prospective study, Robust Assays for Point-of-care Identification of Disease (RAPID), we simultaneously evaluated a POC immunoassay (Sickle SCAN™) to diagnose SCD and a first-generation POC color-based assay to detect anemia...
November 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29147136/step-by-step-strategy-in-the-management-of-residual-hepatolithiasis-using-post-operative-cholangioscopy
#3
REVIEW
Xu-Dong Wen, Tao Wang, Zhu Huang, Hong-Jian Zhang, Bing-Yin Zhang, Li-Jun Tang, Wei-Hui Liu
Hepatolithiasis is the presence of calculi within the intrahepatic bile duct specifically located proximal to the confluence of the left and right hepatic ducts. The ultimate goal of hepatolithiasis treatment is the complete removal of the stone, the correction of the associated strictures and the prevention of recurrent cholangitis. Although hepatectomy could effectively achieve the above goals, it can be restricted by the risk of insufficient residual liver volume, and has a 15.6% rate of residual hepatolithiasis...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29144490/neonatal-lung-ultrasound-exam-guidelines
#4
D Kurepa, N Zaghloul, L Watkins, J Liu
Point-of-care ultrasound (POC-US) is increasingly used especially in emergency and critical-care medicine. It is focused, quick and does not expose patients to ionizing radiation. It encompasses all organ systems and has well-defined indications. Lung ultrasound (LUS) represents one of the most exciting applications in the field of POC-US. It is particularly important to emphasize the role of LUS in neonatology due to the specific pathology inherent in lung immaturity as well as in the particular sensitivity of neonates to repeated radiation exposure...
November 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29144379/a-digital-microfluidics-platform-for-loop-mediated-isothermal-amplification-detection
#5
Beatriz Jorge Coelho, Bruno Veigas, Hugo Águas, Elvira Fortunato, Rodrigo Martins, Pedro Viana Baptista, Rui Igreja
Digital microfluidics (DMF) arises as the next step in the fast-evolving field of operation platforms for molecular diagnostics. Moreover, isothermal schemes, such as loop-mediated isothermal amplification (LAMP), allow for further simplification of amplification protocols. Integrating DMF with LAMP will be at the core of a new generation of detection devices for effective molecular diagnostics at point-of-care (POC), providing simple, fast, and automated nucleic acid amplification with exceptional integration capabilities...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29136589/nucleic-acid-aptamer-based-methods-for-diagnosis-of-infections
#6
REVIEW
Ki Soo Park
Infectious diseases are a serious global problem, which not only take an enormous human toll but also incur tremendous economic losses. In combating infectious diseases, rapid and accurate diagnostic tests are required for pathogen identification at the point of care (POC). In this review, investigations of diagnostic strategies for infectious diseases that are based on aptamers, especially nucleic acid aptamers, oligonucleotides that have high affinities and specificities toward their targets, are described...
November 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29131592/a-paper-plastic-hybrid-microfluidic-device-for-smartphone-based-colorimetric-analysis-of-urine
#7
M Jalal Uddin, Gyeong Jun Jin, Joon Sub Shim
In this work, a disposable paper-plastic hybrid microfluidic lab-on-a-chip (LOC) has been developed and successfully applied for the colorimetric measurement of urine by the smartphone-based optical platform using an "UrineAnalysis" Android app. The developed device was cost-effectively implemented as a stand-alone hybrid LOC by incorporating the paper-based conventional reagent test strip inside the plastic-based LOC microchannel. The LOC device quantitatively investigated the small volume (40 µL) of urine analytes for the colorimetric reaction of glucose, protein, pH and red blood cell (RBC) in integration with the finger-actuating micro pump...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29130601/scaling-up-hiv-viral-load-lessons-from-the-large-scale-implementation-of-hiv-early-infant-diagnosis-and-cd4-testing
#8
Trevor Peter, Clement Zeh, Zachary Katz, Ali Elbireer, Bereket Alemayehu, Lara Vojnov, Alex Costa, Naoko Doi, Ilesh Jani
INTRODUCTION: The scale-up of effective HIV viral load (VL) testing is an urgent public health priority. Implementation of testing is supported by the availability of accurate, nucleic acid based laboratory and point-of-care (POC) VL technologies and strong WHO guidance recommending routine testing to identify treatment failure. However, test implementation faces challenges related to the developing health systems in many low-resource countries. The purpose of this commentary is to review the challenges and solutions from the large-scale implementation of other diagnostic tests, namely nucleic-acid based early infant HIV diagnosis (EID) and CD4 testing, and identify key lessons to inform the scale-up of VL...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29129601/on-chip-signal-amplification-of-magnetic-bead-based-immunoassay-by-aviating-magnetic-bead-chains
#9
Uddin M Jalal, Gyeong Jun Jin, Kyu Shik Eom, Min Ho Kim, Joon S Shim
In this work, a Lab-on-a-Chip (LOC) platform is used to electromagnetically actuate magnetic bead chains for an enhanced immunoassay. Custom-made electromagnets generate a magnetic field to form, rotate, lift and lower the magnetic bead chains (MBCs). The cost-effective, disposable LOC platform was made with a polymer substrate and an on-chip electrochemical sensor patterned via the screen-printing process. The movement of the MBCs is controlled to improve the electrochemical signal up to 230% when detecting beta-type human chorionic gonadotropin (β-hCG)...
November 6, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29128678/efficient-operator-splitting-algorithm-for-joint-sparsity-regularized-spirit-based-parallel-mr-imaging-reconstruction
#10
Jizhong Duan, Yu Liu, Peiguang Jing
Self-consistent parallel imaging (SPIRiT) is an auto-calibrating model for the reconstruction of parallel magnetic resonance imaging, which can be formulated as a regularized SPIRiT problem. The Projection Over Convex Sets (POCS) method was used to solve the formulated regularized SPIRiT problem. However, the quality of the reconstructed image still needs to be improved. Though methods such as NonLinear Conjugate Gradients (NLCG) can achieve higher spatial resolution, these methods always demand very complex computation and converge slowly...
November 8, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29122351/macroaggregation-and-soil-organic-carbon-restoration-in-a-highly-weathered-brazilian-oxisol-after-two-decades-under-no-till
#11
Ademir de Oliveira Ferreira, João Carlos de Moraes Sá, Rattan Lal, Florent Tivet, Clever Briedis, Thiago Massao Inagaki, Daniel Ruiz Potma Gonçalves, Jucimare Romaniw
Conclusions based on studies of the impacts of soil organic carbon (SOC) fractions and soil texture on macroaggregation and SOC stabilization in long-term (>20years) no-till (NT) fields remain debatable. This study was based on the hypothesis that the amount and frequency of biomass-C input associated with NT can be a pathway to formation of macroaggregates and to SOC buildup. The objectives were to: 1) assess the macroaggregate distribution (proportional mass, class mass) and the SOC and particulate organic carbon (POC) stocks of extra-large (8-19mm), large (2-8mm) and small (0...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29121035/ischemic-conditioning-of-human-heart-muscle-depends-on-opioid-receptor-system
#12
Marcin Kunecki, Tomasz Oleksy, Jolanta Biernat, Paweł Kukla, Katarzyna Szwajkos, Piotr Podolec, Marek Deja, Krzysztof Gołba, Wojciech Płazak
BACKGROUND: Despite progress in the invasive treatment of ischemic heart disease, the ability to limit ischemia-reperfusion (I/R) injury remains largely unrealized. Ischemic pre-conditioning (IPC) and post-conditioning (POC) induce the protective mechanisms of resistance against I/R injury. Stimulation of opioid receptors mimic the protective effect of IPC or POC in an animal models. We tested the hypothesis, that IPC and POC provide cardioprotection in opioid-dependent mechanism in human myocardium...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29120648/the-role-of-nanoparticle-design-in-determining-analytical-performance-of-lateral-flow-immunoassays
#13
Li Zhan, Shuang-Zhuang Guo, Fayi Song, Yan Gong, Feng Xu, David R Boulware, Michael C McAlpine, Warren C W Chan, John C Bischof
Rapid, simple, and cost-effective diagnostics are needed to improve healthcare at the point of care (POC). However, the most widely used POC diagnostic, the lateral flow immunoassay (LFA), is ∼1000-times less sensitive and has a smaller analytical range than laboratory tests, requiring a confirmatory test to establish truly negative results. Here, a rational and systematic strategy is used to design the LFA contrast label (i.e., gold nanoparticles) to improve the analytical sensitivity, analytical detection range, and antigen quantification of LFAs...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29118404/a-pocs-super-resolution-restoration-algorithm-based-on-bm3d
#14
Jian Chen, WeiGuo Wang, TingXia Liu, ZhenDong Zhang, HuiBin Gao
The inherent shortcoming of POCS (Projection Onto Convex Sets) is its sensitiveness to noise. The restoration quality of POCS based super resolution will severely decline when the noise is larger. In practical applications, the low resolution images generally include some kinds of noise, such as camera internal noise, transmission system noise and coherent noise. Therefore POCS cannot be used directly in super-resolution restoration for observed low resolution images. In order to solve the noise sensitive problem of the traditional POCS restoration algorithm, we firstly propose to optimize the BM3D (Block-Matching 3D) filtering by mean pre-screening of image blocks and limiting the number of image blocks...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116747/paperfluidic-chip-device-for-small-rna-extraction-amplification-and-multiplexed-analysis
#15
Huaping Deng, Xiaoming Zhou, Qianwen Liu, Bofan Li, Hongxing Liu, Ru Huang, Da Xing
Small RNAs have been considered as potential biomarkers of various human diseases. Sensitive and multiplexed determination of small RNAs with point-of-care (POC) assay would be of great significance. Herein, an integrated paperfluidic chip device for multiplexed small RNA analysis was developed for the first time. In this system, the extraction and purification of small RNA was completed through a poly(ether sulfone) (PES) paper chip without the need for centrifugation. Subsequently, a newly designed hairpin probe-exponential amplification reaction (HP-EXPAR) was directly performed within the extraction paper chip...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29116488/the-relationship-between-clavien-dindo-morbidity-classification-and-oncologic-outcomes-after-colorectal-cancer-resection
#16
Leonardo C Duraes, Luca Stocchi, Scott R Steele, Matthew F Kalady, James M Church, Emre Gorgun, David Liska, Hermann Kessler, Olga A Lavryk, Conor P Delaney
BACKGROUND: Limited data on the relationship between postoperative complications (POCs) after colorectal cancer resection and oncologic outcomes are available. We hypothesized that the increased severity of POCs is associated with progressively worse oncologic outcomes. METHODS: Patients with pathological stages I-III colorectal adenocarcinoma undergoing elective curative resection in a single institution between 2000 and 2012 were identified from a prospectively collected database...
November 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29111256/carbon-biogeochemical-cycle-is-enhanced-by-damming-in-a-karst-river
#17
Qiong Han, Baoli Wang, Cong-Qiang Liu, Fushun Wang, Xi Peng, Xiao-Long Liu
Currently, there is a lack of systematic knowledge concerning carbon (C) biogeochemical cycles in impounded rivers. In this study, we investigated different C species and related environmental factors from July 2007 to June 2008 and from May 2011 to May 2012 in the impounded Wujiang River, SW China to understand the influence of dam construction on the riverine C cycle. The results showed that average concentrations of dissolved CO2, dissolved inorganic C (DIC), dissolved organic C, and particulate organic C (POC) were 81...
October 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29109407/paper-based-sensing-device-for-electrochemical-detection-of-oxidative-stress-biomarker-8-hydroxy-2-deoxyguanosine-8-ohdg-in-point-of-care
#18
Gabriela V Martins, Ana P M Tavares, Elvira Fortunato, M Goreti F Sales
This work presents a cost-effective, label-free in point-of-care (POC) biosensor for the sensitive detection of 8-hydroxy-2'-deoxyguanosine (8-OHdG), the most abundant oxidative product of DNA, that may allow a premature assessment of cancer disease, thereby improving diagnosis, prognostics and survival rates. The device targets the direct detection of 8-OHdG by using for the first time a carbon-ink 3-electrode on a paper substrate coupled to Differential Pulse Voltammetry readings. This design was optimized by adding nanostructured carbon materials to the ink and the conducting polymer PEDOT, enhancing the electrocatalytic properties of the sensor towards 8-OHdG detection...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108003/schistosoma-other-helminth-infections-and-associated-risk-factors-in-preschool-aged-children-in-urban-tanzania
#19
Khadija Said, Jerry Hella, Stefanie Knopp, Tatu Nassoro, Neema Shija, Fatma Aziz, Francis Mhimbira, Christian Schindler, Upendo Mwingira, Anna M Mandalakas, Karim Manji, Marcel Tanner, Jürg Utzinger, Lukas Fenner
BACKGROUND: Despite the high prevalence of helminth infections among preschool-aged children, control programs in sub-Saharan countries primarily focus on school-aged populations. We assessed the prevalence of helminth infections and determined risk factors for infection among preschool-aged children in the urban setting of Dar es Salaam, Tanzania. METHODOLOGY: Starting in October 2015, we conducted a 12-month prospective study among tuberculosis (TB)-exposed children under the age of 5 years and unexposed controls from neighboring households...
November 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29102993/evidence-of-accessibility-and-utility-of-point-of-care-diagnostics-as-an-integral-part-of-prevention-of-mother-to-child-transmission-services-systematic-scoping-review-protocol
#20
Juliet Katoba, Lydia Hangulu, Tivani Phosa Mashamba-Thompson
INTRODUCTION: Point-of-care (POC) testing has been shown to help improve healthcare access in resource-limited settings. However, there is paucity of evidence on accessibility of POC testing for prevention of mother-to-child transmission (PMTCT) in resource-limited settings. We propose to conduct a systematic scoping review to map the evidence on POC testing services for PMTCT. METHODS AND ANALYSIS: A scoping review framework, proposed by Arksey and O'Malley, will guide the study...
November 4, 2017: BMJ Open
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