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https://www.readbyqxmd.com/read/28110011/distributions-of-persistent-organic-contaminants-in-sediments-and-their-potential-impact-on-macrobenthic-faunal-community-of-the-geum-river-estuary-and-saemangeum-coast-korea
#1
Seo Joon Yoon, Seongjin Hong, Bong-Oh Kwon, Jongseong Ryu, Chang-Hee Lee, Jungho Nam, Jong Seong Khim
Over the last 30 years, the Geum River Estuary and Saemangeum Coast have been subject to major environmental changes, including dike construction, reclamation, and development of industrial complexes. This study aimed to: 1) investigate the occurrence of polycyclic aromatic hydrocarbons (PAHs), alkylphenols (APs), and styrene oligomers (SOs), 2) identify the sources of sedimentary organic matter, and 3) determine key environmental factors controlling the macrozoobenthos community structure. A total of 58 surface sediments were collected from the estuary and coastal area in 2014...
January 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28108881/diagnostic-performance-of-point-of-care-ultrasonography-in-identifying-the-etiology-of-respiratory-distress-in-neonates
#2
Harish Rachuri, Tejo Pratap Oleti, Srinivas Murki, Sreeram Subramanian, Jayalatha Nethagani
OBJECTIVES: To determine the diagnostic test performance of Point of care ultrasonography (PoC-USG) for identifying the etiology of respiratory distress (RD) in neonates when combination of radiological and clinical criteria is considered as the gold standard. METHODS: A neonate was included in the study if he/she had RD and underwent x-ray chest and ultrasound within 4 h of admission and the age was less than 24 h. The neonates admitted with non-respiratory illness were chosen as controls...
January 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28107953/visual-detection-of-nucleic-acids-based-on-lateral-flow-biosensor-and-hybridization-chain-reaction-amplification
#3
Na Ying, Chuanjing Ju, Zhongyi Li, Wensen Liu, Jiayu Wan
In this study, a new lateral flow nucleic acid biosensor (LFNAB) using hybridization chain reaction (HCR) for signal amplification was developed for visual detection of nucleic acids with high sensitivity and low cost. A "sandwich-type" detection strategy was employed in our design. The sandwich system of capture probe (CP)/target DNA/reporter probe (RP)-HCR complexes was fabricated as the sensing platform. As the initiator strand, reporter probe propagated a chain reaction of hybridization events between the two hairpin probes modified with biotin, and determined whether long nicked DNA polymers were formed...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28103895/feasibility-of-antiretroviral-treatment-monitoring-in-the-era-of-decentralized-hiv-care-a-systematic-review
#4
REVIEW
Minh D Pham, Lorena Romero, Bruce Parnell, David A Anderson, Suzanne M Crowe, Stanley Luchters
BACKGROUND: Regular monitoring of HIV patients who are receiving antiretroviral therapy (ART) is required to ensure patient benefits and the long-term effectiveness and sustainability of ART programs. Prompted by WHO recommendations for expansion and decentralization of HIV treatment and care in low and middle income countries, we conducted a systematic review to assess the feasibility of treatment monitoring in these settings. METHODS: A comprehensive search strategy was developed using a combination of MeSH and free text terms relevant to HIV treatment and care, health service delivery, health service accessibility, decentralization and other relevant terms...
January 19, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28103450/paper-based-analytical-devices-for-clinical-diagnosis-recent-advances-in-the-fabrication-techniques-and-sensing-mechanisms
#5
Mazhar Sher, Rachel Zhuang, Utkan Demirci, Waseem Asghar
There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians...
January 19, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28102419/towards-encoded-particles-for-highly-multiplexed-colorimetric-point-of-care-autoantibody-detection
#6
Gustav Svedberg, Yunjin Jeong, Hunjong Na, Jisung Jang, Peter Nilsson, Sunghoon Kwon, Jesper Gantelius, Helene Andersson Svahn
Highly multiplexed point of care tests could improve diagnostic accuracy and differential diagnostic capacity in for instance emergency medicine and low resource environments. Available technology platforms for POC biomarker detection are typically simplex or low-plexed, whereas common lab-based microarray systems allow for the simultaneous detection of thousands of DNA or protein biomarkers. In this study, we demonstrate a novel suspension particle array platform that utilizes 900 μm bricks for POC amenable colorimetric biomarker detection with an encoding capacity of over two million...
January 19, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28099134/carboxyhemoglobin-the-forgotten-parameter-of-neonatal-hyperbilirubinemia
#7
Douggl G N Bailey, Hans Fuchs, Roland Hentschel
BACKGROUND: Neonatal hyperbilirubinemia is influenced by a wide variety of factors, one of which is hemolysis. Serious hyperbilirubinemia may lead to a kernicterus with detrimental neurologic sequelae. Patients suffering from hemolytic disease have a higher risk of developing kernicterus. Carbon monoxide (CO), a byproduct of hemolysis or heme degradation, was described by Sjöstrand in the 1960s. It is transported as carboxyhemoglobin (COHb) and exhaled through the lungs. We were interested in a potential correlation between COHb and total serum bilirubin (TSB) and the time course of both parameters...
January 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28098944/validation-of-a-smartphone-based-point-of-care-hemoglobin-assay-for-use-in-dogs
#8
Kate S Farrell, Phillip L Chapman, Lauren A Sullivan
OBJECTIVE: To validate a smartphone-based spectrophotometric assay for point-of-care (POC) measurement of hemoglobin (Hgb) concentration against the standard measurement method in dogs without increases in serum lipemia, hemolysis, or bilirubin. DESIGN: Prospective observational study. SETTING: University teaching hospital. ANIMALS: One hundred thirty-nine dogs that had a CBC and corresponding biochemical profile submitted to the clinical pathology laboratory...
January 18, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28097801/odd-even-alternation-in-tautomeric-porous-organic-cages-with-exceptional-chemical-stability
#9
Saibal Bera, Arghya Basu, Srinu Tothadi, Bikash Garai, Subhrashis Banerjee, Kumar Vanka, Rahul Banerjee
Amine-linked (C-NH) porous organic cages (POCs) are preferred over the imine-linked (C=N) POCs owing to their enhanced chemical stability. In general, amine-linked cages, obtained by the reduction of corresponding imines, are not shape-persistent in the crystalline form. Moreover, they require multistep synthesis. Herein, a one-pot synthesis of four new amine-linked organic cages by the reaction of 1,3,5-triformylphloroglucinol (Tp) with different analogues of alkanediamine is reported. The POCs resulting from the odd diamine (having an odd number of -CH2 groups) is conformationally eclipsed, while the POCs constructed from even diamines adopt a gauche conformation...
January 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28097288/secondary-analysis-of-an-electronic-surveillance-system-combined-with-multi-focal-interventions-for-early-detection-of-sepsis
#10
Bonnie L Westra, Sean Landman, Pranjul Yadav, Michael Steinbach
: To conduct an independent secondary analysis of a multi-focal intervention for early detection of sepsis that included implementation of change management strategies, electronic surveillance for sepsis, and evidence based point of care alerting using the POC AdvisorTM application. METHODS: Propensity score matching was used to select subsets of the cohorts with balanced covariates. Bootstrapping was performed to build distributions of the measured difference in rates/means...
18, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28092466/clinical-performance-of-the-solana%C3%A2-point-of-care-trichomonas-assay-from-clinician-collected-vaginal-swabs-and-urine-specimens-from-symptomatic-and-asymptomatic-women
#11
C A Gaydos, J Schwebke, J Dombrowski, J Marrazzo, J Coleman, B Silver, M Barnes, L Crane, P Fine
BACKGROUND: Solana® (Quidel) is a new rapid (<40 min.) point-of-care (POC) test for qualitative detection of Trichomonas vaginalis (TV) DNA. The assay has two steps: 1) specimen preparation, and 2) amplification and detection using isothermal Helicase-Dependent Amplification (HDA). The objective was to demonstrate the performance of Solana for vaginal swabs and female urines based on comparison to wet mount and TV culture. Performance was also compared to the Aptima-TV assay. METHODS: Urine and four clinician-collected vaginal swabs were collected...
January 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28089198/point-of-care-detection-devices-for-food-safety-monitoring-proactive-disease-prevention
#12
REVIEW
Marie Yung-Chen Wu, Min-Yen Hsu, Shih-Jen Chen, De-Kuang Hwang, Tzung-Hai Yen, Chao-Min Cheng
Food safety has become an increasingly significant public concern in both developed and under-developed nations around the world; it increases morbidity, mortality, human suffering, and economic burden. This Opinion focuses on (i) examining the influence of pathogens and chemicals (e.g., food additives and pesticide residue) on food-borne illnesses, (ii) summarizing food hazards that are present in Asia, and (iii) summarizing the array of current point-of-care (POC) detection devices that have potential applications in food safety monitoring...
January 11, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28079591/point-of-care-diagnostics-extending-the-laboratory-network-to-reach-the-last-mile
#13
Paul K Drain, Christine Rousseau
PURPOSE OF REVIEW: More point-of-care (POC) diagnostic tests are becoming available for HIV diagnosis and treatment in resource-limited settings. These novel technologies have the potential to foster decentralized HIV care and treatment for the benefit of clinical laboratories, HIV clinics, and HIV-infected patients. There continue to be many business, technological, and operational challenges that limit product development and regulatory approval, which limits products available for the required operational and cost-effectiveness studies and delays policy adoption and implementation...
January 11, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28075337/implementation-of-point-of-care-diagnostics-in-rural-primary-healthcare-clinics-in-south-africa-perspectives-of-key-stakeholders
#14
Tivani P Mashamba-Thompson, Ngcwalisa A Jama, Benn Sartorius, Paul K Drain, Rowan M Thompson
INTRODUCTION: Key stakeholders' involvement is crucial to the sustainability of quality point-of-care (POC) diagnostics services in low-and-middle income countries. The aim of this study was to explore key stakeholder perceptions on the implementation of POC diagnostics in rural primary healthcare (PHC) clinics in South Africa. METHOD: We conducted a qualitative study encompassing in-depth interviews with multiple key stakeholders of POC diagnostic services for rural and resource-limited PHC clinics...
January 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28073898/two-stage-isothermal-enzymatic-amplification-for-concurrent-multiplex-molecular-detection
#15
Jinzhao Song, Changchun Liu, Michael G Mauk, Shelley C Rankin, James B Lok, Robert M Greenberg, Haim H Bau
BACKGROUND: The wide array of pathogens responsible for infectious diseases makes it difficult to identify causative pathogens with single-plex tests. Although multiplex PCR detects multiple targets, it is restricted to centralized laboratories, which delays test results or makes multiplexing unavailable, depriving healthcare providers of critical, real-time information. METHODS: To address the need for point-of-care (POC) highly multiplexed tests, we propose the 2-stage, nested-like, rapid (<40 min) isothermal amplification assay, dubbed rapid amplification (RAMP)...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28073036/does-preoperative-oral-carbohydrate-treatment-reduce-the-postoperative-surgical-stress-response-in-lumbar-disc-surgery
#16
Ozlem Korkmaz Dilmen, Ercument Yentur, Yusuf Tunali, Huriye Balci, Mois Bahar
OBJECTIVES: Surgical trauma produces metabolic and hormonal responses, which are characterized by insulin resistance. Due to extension of the preoperative fasting period, which increases the magnitude of postoperative insulin resistance, preoperative oral carbohydrates (POC) have been developed. PATIENTS AND METHODS: This prospective, randomized, controlled study was performed on 43 ASA I-II patients undergoing elective microsurgical lumbar discectomy. The intervention group received oral carbohydrate solution 800mL the night before and 400mL 2h prior to operation...
December 29, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28073029/multiplexed-efficient-on-chip-sample-preparation-and-sensitive-amplification-free-detection-of-ebola-virus
#17
K Du, H Cai, M Park, T A Wall, M A Stott, K J Alfson, A Griffiths, R Carrion, J L Patterson, A R Hawkins, H Schmidt, R A Mathies
An automated microfluidic sample preparation multiplexer (SPM) has been developed and evaluated for Ebola virus detection. Metered air bubbles controlled by microvalves are used to improve bead-solution mixing thereby enhancing the hybridization of the target Ebola virus RNA with capture probes bound to the beads. The method uses thermally stable 4-formyl benzamide functionalized (4FB) magnetic beads rather than streptavidin coated beads with a high density of capture probes to improve the target capture efficiency...
January 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28072822/point-of-care-versus-central-laboratory-measurements-of-hemoglobin-hematocrit-glucose-bicarbonate-and-electrolytes-a-prospective-observational-study-in-critically-ill-patients
#18
Jérôme Allardet-Servent, Melissa Lebsir, Christian Dubroca, Martine Fabrigoule, Sylvie Jordana, Thomas Signouret, Matthias Castanier, Guillemette Thomas, Rettinavelou Soundaravelou, Anne Lepidi, Laurence Delapierre, Guillaume Penaranda, Philippe Halfon, Jean-Marie Seghboyan
INTRODUCTION: Rapid detection of abnormal biological values using point-of-care (POC) testing allows clinicians to promptly initiate therapy; however, there are concerns regarding the reliability of POC measurements. We investigated the agreement between the latest generation blood gas analyzer and central laboratory measurements of electrolytes, bicarbonate, hemoglobin, hematocrit, and glucose. METHODS: 314 paired samples were collected prospectively from 51 critically ill patients...
2017: PloS One
https://www.readbyqxmd.com/read/28068347/microbiologically-confirmed-tuberculosis-factors-associated-with-pre-treatment-loss-to-follow-up-and-time-to-treatment-initiation
#19
Judith Mwansa-Kambafwile, Boitumelo Maitshotlo, Andrew Black
BACKGROUND: The impact of new diagnostics on pre-treatment loss to follow up (Pre-treatment LTFU) has not been widely investigated. The reported rate of pre-treatment LTFU is however lower in studies where Xpert MTB/Rif (Xpert) has been used onsite as opposed to centrally. The use of the Xpert at point of care (POC) could have a role in reducing the pre-treatment LTFU rate among TB patients. We aimed to determine the pre-treatment LTFU rate and the time to treatment initiation as well as to describe associated factors in patients diagnosed with TB using POC Xpert or smear microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28067420/cost-effectiveness-of-cytogenetic-evaluation-of-products-of-conception-by-chorionic-villous-sampling-in-recurrent-miscarriage
#20
Florencia Petracchi, Cecilia Paez, Laura Igarzabal
OBJECTIVE: To compare the cost-effectiveness of performing chorionic villous sampling (CVS) of products of conception (POC) in the evaluation of recurrent miscarriage versus standard evidence based work-up (EBW) of the couple. MATERIAL AND METHODS: A Decision-analytic model was performed in couples with a third miscarriage. Three strategies were considered: 1)the standard EBW of all the patients: comprising parental karyotype, uterine cavity assessment and antiphospholipid antibodies...
January 9, 2017: Prenatal Diagnosis
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