keyword
MENU ▼
Read by QxMD icon Read
search

POC

keyword
https://www.readbyqxmd.com/read/28819345/point-of-care-molecular-test-for-zika-infection
#1
Michael G Mauk, Jinzhao Song, Haim H Bau, Changchun Liu
The recent outbreak of Zika virus (ZIKV) infection has led to a serious threat to public health. Rapid and sensitive diagnostics for ZIKV infection are crucial because Zika infection is usually mild and often asymptomatic, but may have serious consequences to infants born to infected mothers. We report on a simple, sensitive, inexpensive, point-of-care (POC) diagnostic technology for rapid detection of ZIKV in saliva. We use a chemically heated cup for isothermal amplification without a need for electrical power...
June 2017: Clinical Laboratory International
https://www.readbyqxmd.com/read/28819076/-molecularly-targeted-therapy-of-spinocerebellar-ataxia-type-1-by-hmgb1
#2
Kyota Fujita, Hitoshi Okazawa
Spinocerebellar ataxia type 1 (SCA1) is an untreatable neurodegenerative disease. We reported a decrease in HMGB1 levels in the nucleus of cerebellar neurons in mouse SCA 1. The decrease in this DNA architectural protein leads to the impairment of DNA repair and transcription, the two essential nuclear functions, and eventually causes neurodegeneration. We have designed a gene therapy using AAV-HMGB1 and tested it using the mouse model. Based on the results of these proof of concept (POC) studies, we are now preparing GMP-level AAV vector and designing human clinical trials...
August 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28817643/peripheral-clinic-versus-centralized-laboratory-based-xpert-mtb-rif-performance-experience-gained-from-a-pragmatic-stepped-wedge-trial-in-botswana
#3
Tefera Agizew, Rosanna Boyd, Ndwapi Ndwapi, Andrew Auld, Joyce Basotli, Sambayawo Nyirenda, Zegabriel Tedla, Anikie Mathoma, Unami Mathebula, Chawangwa Lesedi, Sherri Pals, Anand Date, Heather Alexander, Thomas Kuebrich, Alyssa Finlay
BACKGROUND: In 2011, the Botswana National Tuberculosis Program adopted World Health Organization guidelines and introduced Xpert MTB/RIF (Xpert) assay to support intensified case finding among people living with HIV enrolling in care. An evaluation was designed to assess performance under operational conditions to inform the national Xpert scale-up. METHODS: Xpert was implemented from August 2012 through November 2014 with 13 GeneXpert instruments (GeneXpert) deployed in a phased approach over nine months: nine centralized laboratory and four point-of-care (POC) peripheral clinics...
2017: PloS One
https://www.readbyqxmd.com/read/28814634/state-dependent-sensorimotor-gating-in-a-rhythmic-motor-system
#4
Rachel S White, Robert M Spencer, Michael P Nusbaum, Dawn M Blitz
Sensory feedback influences motor circuits and/or their projection neuron inputs to adjust ongoing motor activity, but its efficacy varies. Currently, less is known about regulation of sensory feedback onto projection neurons that control downstream motor circuits than about sensory regulation of the motor circuit neurons themselves. Here, we tested whether sensory feedback onto projection neurons is sensitive only to activation of a motor system, or also to the modulatory state underlying that activation, using the crab Cancer borealis stomatogastric nervous system...
August 16, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28810994/comparison-of-point-of-care-versus-laboratory-troponin-testing-in-an-emergency-department-setting
#5
Michael Juliano, Courtney Wason
BACKGROUND: There have been concerns regarding troponin results accuracy between point-of-care (POC) testing preformed in an emergency department (ED) setting and laboratory testing. The purpose of this study was to compare the results of cardiac troponin I testing as concerns POC testing and laboratory analysis as a way to show that these results are interchangeable. METHODS: A retrospective chart review was performed from October 2012 through September 2013 to identify all patients who presented to the ED that received both a POC and laboratory troponin associated with the same blood draw...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807814/development-of-a-chromosomal-microarray-test-for-the-detection-of-abnormalities-in-formalin-fixed-paraffin-embedded-products-of-conception-specimens
#6
Troy J Gliem, Umut Aypar
Testing the products of conception (POC) provides information regarding the cause of fetal loss, and helps determine the recurrence risk for future losses and chromosome abnormalities in subsequent pregnancies. Historically, the Mayo Clinic Cytogenetics Laboratory performed targeted fluorescent in situ hybridization (FISH) testing to identify aneuploidy of only certain chromosomes in formalin-fixed, paraffin-embedded (FFPE) POC samples. Chromosomal microarray (CMA) studies utilizing the Affymetrix OncoScan™ FFPE Assay can detect copy number changes across the genome...
August 11, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28802000/pmepa1-induced-by-rankl-p38-mapk-pathway-has-a-novel-role-in-osteoclastogenesis
#7
Noboru Funakubo, Xianghe Xu, Toshio Kukita, Seiji Nakamura, Hiroshi Miyamoto, Akiko Kukita
Osteoclasts are multinucleated cells formed by fusion of preosteoclasts (POCs) derived from cells of the monocyte/macrophage lineage. We have reported a culture system that supports the formation of POCs from stroma-depleted rat bone marrow cells. Global gene expression analysis of this culture system identified genes highly expressed in POCs. Here, we have analyzed the expression and function of one of these highly expressed genes, prostate transmembrane protein androgen induced 1 (Pmepa1), a target of TGF-β and binds Nedd4 ubiquitin ligase, which plays a role in intracellular trafficking...
August 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28800728/feasibility-and-diagnostic-accuracy-of-point-of-care-handheld-echocardiography-in-acute-ischemic-stroke-patients-a-pilot-study
#8
Peter Kraft, Anna Fleischer, Silke Wiedmann, Viktoria Rücker, Daniel Mackenrodt, Caroline Morbach, Uwe Malzahn, Christoph Kleinschnitz, Stefan Störk, Peter U Heuschmann
BACKGROUND: Standard echocardiography (SE) is an essential part of the routine diagnostic work-up after ischemic stroke (IS) and also serves for research purposes. However, access to SE is often limited. We aimed to assess feasibility and accuracy of point-of-care (POC) echocardiography in a stroke unit (SU) setting. METHODS: IS patients were recruited on the SU of the University Hospital Würzburg, Germany. Two SU team members were trained in POC echocardiography for a three-month period to assess a set of predefined cardiac parameters including left ventricular ejection fraction (LVEF)...
August 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28800620/experimental-study-of-ascs-combined-with-poc-pla-patch-for-the-reconstruction-of-full-thickness-chest-wall-defects
#9
Yuanzheng Zhang, Shuo Fang, Jiezhi Dai, Lei Zhu, Hao Fan, Weiya Tang, Yongjie Fan, Haiying Dai, Peipei Zhang, Ying Wang, Xin Xing, Chao Yang
To explore the repairing effect of combination of adipose stem cells (ASCs) and composite scaffolds on CWR, the electrospun Poly 1, 8-octanediol-co-citric acid (POC)-poly-L-lactide acid (PLA) composite scaffolds were prepared, followed by in vitro and in vivo biocompatibility evaluation of the scaffolds. Afterwards, ASCs were seeded on POC-PLA to construct the POC-PLA-ASCs scaffolds, and the POC-PLA, POC-PLA-ASCs, and traditional materials expanded polytetrafluoroethylene (ePTFE) were adopt for CWR in New Zealand white (NZW) rabbit models...
2017: PloS One
https://www.readbyqxmd.com/read/28798890/evaluation-of-cortez-onestep-chlamydia-rapicard%C3%A2-insta-test-for-the-detection-of-chlamydia-trachomatis-in-pregnant-women-at-mbare-polyclinic-in-harare-zimbabwe
#10
Stephen Stephen, Chiwoneso Gwyneth Elizabeth Muchaneta-Kubara, Marshall Wesley Munjoma, Gibson Mandozana
BACKGROUND: Cervical chlamydia infection poses high risk of pregnancy complications and neonatal infection. Reference methods for the detection of chlamydia infection are not available for routine use in developing countries. Point-of-care (POC) tests can bridge this gap. This study evaluated Cortez Onestep Chlamydia Rapicard™ insta test for the detection of Chlamydia trachomatis in pregnant women at Mbare Polyclinic and determined the prevalence of C. trachomatis. METHODS: This was a cross sectional study in 242 pregnant women aged ≥18 years attending their first ANC visit at Mbare polyclinic in Harare, Zimbabwe...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28798539/acoustofluidic-bacteria-separation
#11
Sixing Li, Fen Ma, Hunter Bachman, Craig E Cameron, Xiangqun Zeng, Tony Jun Huang
Bacterial separation from human blood samples can help with the identification of pathogenic bacteria for sepsis diagnosis. In this work, we report an acoustofluidic device for label-free bacterial separation from human blood samples. In particular, we exploit the acoustic radiation force generated from a tilted-angle standing surface acoustic wave (taSSAW) field to separate E. coli from human blood cells based on their size difference. Flow cytometry analysis of the E. coli separated from red blood cells (RBCs) shows a purity of more than 96%...
January 1, 2017: Journal of Micromechanics and Microengineering: Structures, Devices, and Systems
https://www.readbyqxmd.com/read/28797715/universal-point-of-care-testing-for-lynch-syndrome-in-patients-with-upper-tract-urothelial-carcinoma
#12
Michael J Metcalfe, Firas G Petros, Priya Rao, Maureen E Mork, Lianchun Xiao, Russell R Broaddus, Surena F Matin
BACKGROUND: Patients with Lynch syndrome (LS) are at risk for upper tract urothelial carcinoma (UTUC). We aim to identify the most reliable means of point-of-care (POC) screening for LS in UTUC patients. METHODS: From January 2013 through July 2016, 115 consecutive UTUC patients without a history of LS were universally screened during their follow-up. We evaluated patient/family history (Amsterdam criteria I [AMS1] and II [AMS2]), tumor immunohistochemistry (IHC) for mismatch repair proteins (MMRP), and microsatellite instability (MSI)...
August 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28797128/field-evaluation-of-a-schistosome-circulating-cathodic-antigen-rapid-test-kit-at-point-of-care-for-mapping-of-schistosomiasis-endemic-districts-in-the-gambia
#13
Bakary Sanneh, Ebrima Joof, Abdoulie M Sanyang, Kristen Renneker, Yaya Camara, Alhagie Papa Sey, Sheriffo Jagne, Ignatius Baldeh, Serign Jawo Ceesay, Sana M Sambou, Kisito Ogoussan
BACKGROUND: Studies in Sub Saharan Africa have shown that the Circulating Cathodic Antigen point-of-care-test (POC-CCA) is more accurate in the detections of S. mansoni than the microscopic Kato-Katz technique but less is known about the accuracy of this rapid test in detecting S. haematobium infections. This study was intended to evaluate the field accuracy of POC-CCA as a rapid test kit for schistosomiasis mapping in The Gambia. METHODS: This prospective study was conducted in 4 regions in the country...
2017: PloS One
https://www.readbyqxmd.com/read/28792194/laparoscopic-partial-nephrectomy-for-tumors-7cm-and-above-perioperative-outcomes
#14
Matvey Tsivian, Efrat Tsivian, Yury Stanevsky, Roman Bass, A Ami Sidi, Alexander Tsivian
PURPOSE: To assess and report the outcomes of laparoscopic partial nephrectomy )LPN) for T2 renal masses. MATERIALS AND METHODS: Retrospective review of patients undergoing LPN for clinically localized renal masses ≥7cm between the years 2005-2016. Descriptive analyses were generated for demographics, lesion characteristics, perioperative variables (operative time, warm ischemia time (WIT), estimated blood loss (EBL), intra-operative and post-operative complications (IOC and POC) and pathologic variables (pathology, subtype and Fuhrman grade)...
August 8, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28781062/value-of-geriatric-screening-and-assessment-in-predicting-postoperative-complications-in-patients-older-than-70-years-undergoing-surgery-for-colorectal-cancer
#15
Katleen Fagard, Julie Casaer, Albert Wolthuis, Johan Flamaing, Koen Milisen, Jean-Pierre Lobelle, Hans Wildiers, Cindy Kenis
OBJECTIVES: This study examines the association between geriatric screening and geriatric assessment (GA) and the risk of 30-day postoperative complications (30d-POCs) in older patients undergoing surgery for colorectal cancer (CRC). MATERIALS AND METHODS: Patients were identified from a prospectively collected database (2009-2015). All patients underwent geriatric screening with the G8 screening tool and the Flemish version of the Triage Risk Screening Tool (fTRST)...
August 3, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28772170/diagnostic-accuracy-of-the-real-time-pcr-cobas-%C3%A2-liat-%C3%A2-influenza-a-b-assay-and-the-alere-i-influenza-a-b-near-isothermal-nucleic-acid-amplification-assay-for-the-detection-of-influenza-using-adult-nasopharyngeal-specimens
#16
Stephen Young, Patrick Illescas, Joclin Nicasio, Joanna Jackson Sickler
BACKGROUND: Accurate detection of influenza requires diagnostic testing; however, methods such as RADTs and central laboratory-based tests are limited by low sensitivity and time constraints, respectively. OBJECTIVE: To compare the performances of the cobas(®) Liat(®) Influenza A/B and Alere™ i Influenza A&B point-of-care (POC) assays for detecting influenza A and B viruses using fresh nasopharyngeal specimens with the GenMark Dx(®) Respiratory Viral Panel as the reference method, a FDA cleared IVD PCR test...
July 26, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28768475/the-cost-utility-of-point-of-care-troponin-testing-to-diagnose-acute-coronary-syndrome-in-primary-care
#17
Michelle M A Kip, Hendrik Koffijberg, Marco J Moesker, Maarten J IJzerman, Ron Kusters
BACKGROUND: The added value of using a point-of-care (POC) troponin test in primary care to rule out acute coronary syndrome (ACS) is debated because test sensitivity is inadequate early after symptom onset. This study investigates the potential cost-utility of diagnosing ACS by a general practitioner (GP) when a POC troponin test is available versus GP assessment only. METHODS: A patient-level simulation model was developed, representing a hypothetical cohort of the Dutch population (>35 years) consulting the GP with chest complaints...
August 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28765778/a-randomized-controlled-trial-of-an-individualized-nutrition-counseling-program-matched-with-a-transtheoretical-model-for-overweight-and-obese-females-in-thailand
#18
Sasipha Karintrakul, Jongjit Angkatavanich
BACKGROUND/OBJECTIVE: Effective weight reduction remains a challenge throughout the world as the prevalence of obesity and its consequences are increasing. This study aimed to determine the effects of an individualized nutrition counseling program (IC) matched with a transtheoretical model (TTM) for overweight and obese subjects. SUBJECTS/METHODS: Fifty overweight and obese subjects aged 19-60 years with a body mass index ≥ 23 kg/m(2) were enrolled in the weight reduction study...
August 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28763247/capillary-blood-for-point-of-care-testing
#19
Ruihua Tang, Hui Yang, Jane Ru Choi, Yan Gong, MinLi You, Ting Wen, Ang Li, XiuJun Li, Bo Xu, Sufeng Zhang, Qibing Mei, Feng Xu
Clinically, blood sample analysis has been widely used for health monitoring. In hospitals, arterial and venous blood are utilized to detect various disease biomarkers. However, collection methods are invasive, painful, may result in injury and contamination, and skilled workers are required, making these methods unsuitable for use in a resource-limited setting. In contrast, capillary blood is easily collected by a minimally invasive procedure and has excellent potential for use in point-of-care (POC) health monitoring...
August 1, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28762248/engineering-brown-fat-into-skeletal-muscle-using-ultrasound-targeted-microbubble-destruction-gene-delivery-in-obese-zucker-rats-proof-of-concept-design
#20
Raul A Bastarrachea, Jiaxi Chen, Jack W Kent, Edna J Nava-Gonzalez, Ernesto Rodriguez-Ayala, Marcel M Daadi, Barbara Jorge, Hugo Laviada-Molina, Anthony G Comuzzie, Shuyuan Chen, Paul A Grayburn
Ultrasound-targeted microbubble destruction (UTMD) is a novel means of tissue-specific gene delivery. This approach systemically infuses transgenes precoupled to gas-filled lipid microbubbles that are burst within the microvasculature of target tissues via an ultrasound signal resulting in release of DNA and transfection of neighboring cells within the tissue. Previous work has shown that adenovirus containing cDNA of UCP-1, injected into the epididymal fat pads in mice, induced localized fat depletion, improving glucose tolerance, and decreasing food intake in obese diabetic mice...
July 31, 2017: IUBMB Life
keyword
keyword
88062
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"