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https://www.readbyqxmd.com/read/29350517/cellphone-enabled-microwell-based-microbead-aggregation-assay-for-portable-biomarker-detection
#1
Weiwei Cui, Meihang He, Luye Mu, Zuzeng Lin, Yanyan Wang, Wei Pang, Mark A Reed, Xuexin Duan
Quantitative biomarker detection methods featured with rapidity, high accuracy, and label-free are demonstrated for the development of point-of-care (POC) technologies or "beside" diagnostics. Microbead aggregation via protein-specific linkage provides an effective approach for selective capture of biomarkers from the samples, and can directly readout the presence and amount of the targets. However, sensors or microfluidic analyzers that can accurately quantify the microbead aggrega-tion are scared. In this work, we demonstrate a microwell-based microbeads analyzing system, by which online manipula-tions of microbeads including trapping, arraying, and rotations can be realized, providing a series of microfluidic approaches to layout the aggregated microbeads for further convenient characterizations...
January 19, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29349773/progestin-only-and-combined-oral-contraceptives-and-receptor-defined-premenopausal-breast-cancer-risk-the-norwegian-women-and-cancer-study
#2
Marit Busund, Nora S Bugge, Tonje Braaten, Marit Waaseth, Charlotta Rylander, Eiliv Lund
Receptor-defined subtypes of breast cancer represent distinct cancer types and have differences in risk factors. Whether the two main hormonal forms of oral contraceptives (OCs); i.e. progestin-only (POC) and combined oral contraceptives (COC), are differentially associated with these subtypes are not well known. The aim of this study was to assess the effect of POC and COC use on hormone receptor-defined breast cancer risk in premenopausal women in a prospective population-based cohort - The Norwegian Women and Cancer study (NOWAC)...
January 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29346114/or-net-a-service-oriented-architecture-for-safe-and-dynamic-medical-device-interoperability
#3
Martin Kasparick, Malte Schmitz, Björn Andersen, Max Rockstroh, Stefan Franke, Stefan Schlichting, Frank Golatowski, Dirk Timmermann
Modern surgical departments are characterized by a high degree of automation supporting complex procedures. It recently became apparent that integrated operating rooms can improve the quality of care, simplify clinical workflows, and mitigate equipment-related incidents and human errors. Particularly using computer assistance based on data from integrated surgical devices is a promising opportunity. However, the lack of manufacturer-independent interoperability often prevents the deployment of collaborative assistive systems...
January 18, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29344980/analytical-validation-of-a-new-point-of-care-assay-for-serum-amyloid-a-in-horses
#4
D Schwartz, N Pusterla, S Jacobsen, M M Christopher
BACKGROUND: Serum amyloid A (SAA) is a major acute phase protein in horses. A new point-of-care (POC) test for SAA (Stablelab) is available, but studies evaluating its analytical accuracy are lacking. OBJECTIVES: Evaluate the analytical performance of the SAA POC test by: (1) determining linearity and imprecision, (2) comparing results in whole blood with those in serum or plasma, and (3) comparing POC results with those obtained using a previously validated turbidimetric immunoassay (TIA)...
January 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29340458/morbidity-of-schistosomiasis-mansoni-in-a-low-endemic-setting-in-ouro-preto-minas-gerais-brazil
#5
Carolina Coimbra Marinho, André Caldeira Grobério, Christiane Torres Felício da Silva, Thaysa Lorranne Fernandes de Lima, Rosiane Cristina Dos Santos, Lúcia Gomes de Araújo, Vivian Walter Dos Reis, George Luiz Lins Machado-Coelho
INTRODUCTION: Despite the advances of disease control programs, severe forms of schistosomiasis are prevalent. The prevalence of the disease in areas frequented by tourists urges for permanent prevention and control. The aim of this study was to describe the morbidity of schistosomiasis in the district of Antônio Pereira, Ouro Preto, Minas Gerais, Brazil. METHODS: The proportion of positives was defined by Kato-Katz coproscopy and urinary POC-CCA rapid test. Hepatosplenic form was diagnosed using abdominal ultrasound...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340299/prospective-study-of-the-feasibility-of-point-of-care-testing-strategy-for-carbapenem-resistant-organism-detection
#6
Rahul Pannala, Bruce Baldwin, Vijay Aluru, Thomas E Grys, Jordan Holmes, Laurence J Miller, M Edwyn Harrison, Cuong C Nguyen, Fred C Tenover, David Persing, Douglas O Faigel
Background/aims:  In an investigator-initiated, prospective study, we evaluated the feasibility of a five-gene sequence point-of-care (POC) testing strategy (Xpert CARBA-R Assay, Cepheid Inc., Sunnyvale, CA, USA), compared to reference laboratory PCR (48 - 72 hours turnaround time, two gene sequences), in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and in a hospital outbreak investigation. Methods:  After informed consent, patients undergoing ERCP (September 2015 - April 2016, n = 191) at Mayo Clinic and potential hospital contacts (n = 9) of an index carbapenem-resistant organism (CRO)-positive inpatient were included...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29336004/point-of-care-urine-ethyl-glucuronide-testing-to-detect-alcohol-use-among-hiv-hepatitis-b-virus-coinfected-adults-in-zambia
#7
Michael J Vinikoor, Zude Zyambo, Monde Muyoyeta, Geetanjali Chander, Michael S Saag, Karen Cropsey
In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification test-consumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64...
January 15, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29324838/canine-visceral-leishmaniasis-diagnosis-and-management-of-the-reservoir-living-among-us
#8
REVIEW
Bruno L Travi, Anabela Cordeiro-da-Silva, Filipe Dantas-Torres, Guadalupe Miró
This article reviews essential topics of canine visceral leishmaniasis (CVL) due to Leishmania infantum infection. It focuses on the current serological and molecular diagnostic methods used in epidemiological research and veterinary clinics to diagnose CVL and includes new point-of-care (POC) tests under development. The efficacy of different treatment regimens on the clinical improvement and infectiousness of dogs is also addressed. In the last section, the review provides a critical appraisal of the effectiveness of different control measures that have been implemented to curb disease transmission...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29323478/simultaneous-detection-of-antibiotic-resistance-genes-on-paper-based-chip-using-ru-phen-2dppz-2-turn-on-fluorescence-probe
#9
Bofan Li, Xiaoming Zhou, Hongxing Liu, Huaping Deng, Ru Huang, Da Xing
Antibiotic resistance, the ability of some bacteria to resist antibiotic drug, has been a major global health burden due to the extensive use of antibiotic agents. Antibiotic resistance is encoded via respective genes, hence the specific detection of these genes is necessary for diagnostic and treat of antibiotic resistance cases. Conventional methods for monitoring antibiotic resistance genes require sample to be transported to a central laboratory for tedious and sophisticated tests, which is grueling and time-consuming...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29321578/distinction-of-plasmodium-ovale-wallikeri-and-plasmodium-ovale-curtisi-using-quantitative-polymerase-chain-reaction-with-high-resolution-melting-revelation
#10
V Joste, C Kamaliddin, E Kendjo, V Hubert, N Argy, S Houzé
Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) have been described as two distinct species, only distinguishable by molecular methods such as PCR. Because of no well-defined endemic area and a variable clinical presentation as higher thrombocytopenia and nausea associated with Pow infection and asymptomatic forms of the pathology with Poc infection, rapid and specific identification of Plasmodium ovale curtisi and Plasmodium ovale wallikeri are needed. The aim of the study was to evaluate a new quantitative real-time PCR coupled with high resolution melting revelation (qPCR-HRM) for identification of both species...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321459/practical-high-performance-lateral-flow-assay-based-on-autonomous-microfluidic-replacement-on-a-film
#11
Yusuke Fuchiwaki, Kenji Goya, Masato Tanaka
Although paper-based microfluidic devices are an ideal platform for point-of-care (POC) diagnostics, it is difficult to achieve microfluidic control required for sensitive analyses such as ELISA on a paper substrate. Here, we present a novel lateral-flow test chip that can perform operations similar to a pump, such as flowing, stopping, and replacing a solution, just by adding the solution onto an inlet port. The chip was fabricated by laminating paper, film, and adhesive tape. For sensitive and accurate detection in an immunoassay, the transparency and flatness of the substrate is crucial for precise analysis of weak light generated by a specific antigen-antibody reaction; however, paper is not flat and is opaque...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29313682/programmable-nucleic-acid-nanoswitches-for-the-rapid-single-step-detection-of-antibodies-in-bodily-fluids
#12
Alessandro Porchetta, Rudy Ippodrino, Bruna Marini, Arnaldo Caruso, Francesca Caccuri, Francesco Ricci
Antibody detection plays a pivotal role in the diagnosis of pathogens and monitoring the success of vaccine immunization. However, current serology techniques require multiple, time-consuming washing and incubation steps, which limit their applicability in point-of-care (POC) diagnostics and high-throughput assays. We developed here a nucleic acid nanoswitch platform able to instantaneously measure immunoglobulins of type G and E (IgG and IgE) levels directly in blood serum and other bodily fluids. The system couples the advantages of target-binding induced colocalization and nucleic acid conformational-change nanoswitches...
January 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29310956/medication-history-versus-point-of-care-platelet-activity-testing-in-patients-with-intracerebral-hemorrhage
#13
Matthew B Maas, Andrew M Naidech, Minjee Kim, Ayush Batra, Edward M Manno, Farzaneh A Sorond, Shyam Prabhakaran, Eric M Liotta
OBJECTIVE: We evaluated whether reduced platelet activity detected by point-of-care (POC) testing is a better predictor of hematoma expansion and poor functional outcomes in patients with intracerebral hemorrhage (ICH) than a history of antiplatelet medication exposure. METHODS: Patients presenting with spontaneous ICH were enrolled in a prospective observational cohort study that collected demographic, clinical, laboratory, and radiographic data. We measured platelet activity using the PFA-100 (Siemens AG, Germany) and VerifyNow-ASA (Accumetrics, CA) systems on admission...
January 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29306784/trace-metals-partitioning-between-particulate-and-dissolved-phases-along-a-tropical-mangrove-estuary-can-gio-vietnam
#14
Nguyen Thanh-Nho, Emilie Strady, Tran-Thi Nhu-Trang, Frank David, Cyril Marchand
Mangroves can be considered as biogeochemical reactors along (sub)tropical coastlines, acting both as sinks or sources for trace metals depending on environmental factors. In this study, we characterized the role of a mangrove estuary, developing downstream a densely populated megacity (Ho Chi Minh City, Vietnam), on the fate and partitioning of trace metals. Surface water and suspended particulate matter were collected at four sites along the estuarine salinity gradient during 24 h cycling in dry and rainy seasons...
December 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29305096/automated-real-time-detection-of-drug-resistant-mycobacterium-tuberculosis-on-a-lab-on-a-disc-by-recombinase-polymerase-amplification
#15
I L G Law, J F C Loo, H C Kwok, H Y Yeung, C C H Leung, M Hui, S Y Wu, H S Chan, Y W Kwan, H P Ho, S K Kong
With the emergence of multi- and extensive-drug (MDR/XDR) resistant Mycobacterium tuberculosis (M. tb), tuberculosis (TB) persists as one of the world's leading causes of death. Recently, isothermal DNA amplification methods received much attention due to their ease of translation onto portable point-of-care (POC) devices for TB diagnosis. In this study, we aimed to devise a simple yet robust detection method for M. tb. Amongst the numerous up-and-coming isothermal techniques, Recombinase Polymerase Amplification (RPA) was chosen for a real-time detection of TB with or without MDR...
January 2, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29298917/point-of-care-ultrasound-a-trend-in-health-care
#16
Anita M Buerger, Kevin R Clark
PURPOSE: To discuss the current and growing use of point-of-care (POC) ultrasound in the management and care of patients. METHODS: Several electronic research databases were searched to find articles that emphasized the use of POC ultrasound by health care providers who manage and treat critically ill or injured patients. Thirty-five relevant peer-reviewed journal articles were selected for this literature review. RESULTS: Common themes identified in the literature included the use of POC ultrasound in emergency medicine, military medicine, and remote care; comparison of POC ultrasound to other medical imaging modalities; investigation of the education and training required for nonimaging health care professionals who perform POC ultrasound in their practices; and discussion of the financial implications and limitations of POC ultrasound...
November 2017: Radiologic Technology
https://www.readbyqxmd.com/read/29291592/improving-sensitivity-of-a-miniaturized-label-free-electrochemical-biosensor-using-zigzag-electrodes
#17
Yi-Ching Kuo, Chih-Kung Lee, Chih-Ting Lin
Cardiovascular disease (CVD) is a leading cause of death among chronic diseases worldwide. Therefore, it is important to be able to detect CVD biomarkers early so that patients can be diagnosed properly and begin treatment as soon as possible. To detect biomarkers more conveniently, point-of-care (PoC) biosensors, which are easy to use and are of low cost, are becoming even more necessary. This paper focuses on developing a label-free electrochemical biosensor with high sensitivity for PoC applications to detect CVD biomarkers such as S100 beta proteins and C-reactive proteins (CRP)...
December 2, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29291093/portable-device-for-the-detection-of-colorimetric-assays
#18
G S Luka, E Nowak, J Kawchuk, M Hoorfar, H Najjaran
In this work, a low-cost, portable device is developed to detect colorimetric assays for in-field and point-of-care (POC) analysis. The device can rapidly detect both pH values and nitrite concentrations of five different samples, simultaneously. After mixing samples with specific reagents, a high-resolution digital camera collects a picture of the sample, and a single-board computer processes the image in real time to identify the hue-saturation-value coordinates of the image. An internal light source reduces the effect of any ambient light so the device can accurately determine the corresponding pH values or nitrite concentrations...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29289308/creasensor-simple-technology-for-creatinine-detection-in-plasma
#19
Francesco Dal Dosso, Deborah Decrop, Elena Pérez-Ruiz, Devin Daems, Hannah Agten, Osamah Al-Ghezi, Olivier Bollen, Jolien Breukers, Florian De Rop, Maria Katsafadou, Jens Lepoudre, Linye Lyu, Pieter Piron, Robbe Saesen, Shoera Sels, Rani Soenen, Ellen Staljanssens, Jehan Taraporewalla, Tadej Kokalj, Dragana Spasic, Jeroen Lammertyn
The lab-on-a-chip (LOC) field has witnessed an excess of new technology concepts, especially for the point-of-care (POC) applications. However, only few concepts reached the POC market often because of challenging integration with pumping and detection systems as well as with complex biological assays. Recently, a new technology termed SIMPLE was introduced as a promising POC platform due to its features of being self-powered, autonomous in liquid manipulations, cost-effective and amenable to mass production...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29287210/combined-use-of-radiocarbon-and-stable-carbon-isotope-to-constrain-the-sources-and-cycling-of-particulate-organic-carbon-in-a-large-freshwater-lake-china
#20
Jingan Chen, Haiquan Yang, Yan Zeng, Jianyang Guo, Yilong Song, Wei Ding
The concentrations and isotopic compositions of dissolved inorganic carbon (DIC) and particulate organic carbon (POC) were measured in order to better constrain the sources and cycling of POC in Lake Fuxian, the largest deep freshwater lake in China. Model results based on the combined δ13C and Δ14C, showed that the average lake-wide contributions of autochthonous POC, terrestrial POC, and resuspended sediment POC to the bulk POC in Lake Fuxian were 61%, 22%, and 17%, respectively. This indicated autochthonous POC might play a dominant role in sustaining large oligotrophic lake ecosystem...
December 26, 2017: Science of the Total Environment
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