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HAART HIV guideline

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https://www.readbyqxmd.com/read/27806085/genotoxic-and-cytotoxic-effects-of-antiretroviral-combinations-in-mice-bone-marrow
#1
Aroldo Vieira de Moraes Filho, Cláudia de Jesus Silva Carvalho, Cristiene Costa Carneiro, Camila Regina do Vale, Débora Cristina da Silva Lima, Wanessa Fernandes Carvalho, Thiago Bernardi Vieira, Daniela de Melo E Silva, Kênya Silva Cunha, Lee Chen-Chen
Commonly used guidelines for the management of human immunodeficiency virus (HIV) infection (highly active antiretroviral therapy, HAART) include drug combinations such as tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) and combivir [zidovudine (AZT) + 3TC] + efavirenz (EFV). These combinations may enhance the genotoxic effects induced by such drugs individually, since the therapy requires lifelong adherence and the drugs have unknown effects during treatment. Thus, the evaluation of the benefits and risks of HAART is of great importance...
2016: PloS One
https://www.readbyqxmd.com/read/27789849/cervical-cancer-screening-practices-knowledge-of-screening-and-risk-and-highly-active-antiretroviral-therapy-adherence-among-women-living-with-human-immunodeficiency-virus-in-lima-peru
#2
Jeanne R Delgado, Luis Menacho, Eddy R Segura, Fernando Roman, Robinson Cabello
Cervical cancer (CC) is the leading cause of cancer death among Peruvian women. Awareness shown by women living with HIV (WLHIV) of their increased risk and Papanicoloau (Pap) smear frequency is understudied, particularly in Peru. We assessed the uptake of guidelines-based CC screening practices and its associations with two predictors, knowledge of CC screening and risk and highly active antiretroviral therapy (HAART) adherence, among WLHIV. Collected by self-administered questionnaires from 2014 to 2016, we analyzed the data of 71 WLHIV...
October 27, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27755152/hepatocellular-carcinoma-in-patients-with-hiv
#3
Imane El Dika, James J Harding, Ghassan K Abou-Alfa
PURPOSE OF REVIEW: Hepatocellular carcinoma (HCC) is becoming an important cause of mortality in patients with HIV, attributed to coinfection with hepatitis C virus, hepatitis B virus, and the longer survival advantage these patients are achieving after introducing the highly active antiretroviral therapy (HAART) regimens. RECENT FINDINGS: In addition to hepatitis infection, immunosuppression secondary to HIV infection, direct impact of the virus on liver parenchyma, and the use of hepatotoxic antiretroviral drugs, all contribute to HCC pathogenesis...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27754259/os-37-02-hypertension-in-hiv-infected-adults-in-north-central-nigeria-prevalence-associated-risk-factors-and-assessment-of-risk-using-the-framingham-risk-score
#4
Ganiyu Amusa, Babatunde Awokola, Godsent Isiguzo, James Onuh, Samuel Uguru, David Oke, Solomon Danbauchi, Basil Okeahialam
OBJECTIVE: To evaluate the prevalence of Hypertension and associated risk factors in HIV+ adults and assessment of these risks using the Framingham risk score 'FRS'. DESIGN AND METHOD: A cross-sectional analytical study. One hundred and fifty consecutive HIV+ adults presenting at the HIV clinic of Jos University Teaching Hospital (90 on HAART) with 50 HIV- as controls were recruited. Relevant history, physical examination (including blood pressure measured according to standard guidelines), laboratory specimen (fasting plasma sugar and lipids, CD4 count and viral load) and electrocardiogram were obtained from the participants...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27740592/the-effectiveness-of-a-bioactive-food-compound-in-the-lipid-control-of-individuals-with-hiv-aids
#5
Rosângela Dos Santos Ferreira, Rita de Cássia Avellaneda Guimarães, Elenir Rose Jardim Cury Pontes, Valter Aragão do Nascimento, Priscila Aiko Hiane
Cardiovascular events due to decompensated lipid metabolism are commonly found in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) patients using anti-retroviral therapy (HAART). Thus, the aim of this study was to identify the effect of a bioactive food compound (BFC) containing functional foods on individuals with HIV undergoing HAART. Particularly, this study aims to verify the clinical outcome in the change of the lipid profile due to the use of this compound. This study includes 115 individuals with HIV on HAART...
October 8, 2016: Nutrients
https://www.readbyqxmd.com/read/27643224/os-37-02-hypertension-in-hiv-infected-adults-in-north-central-nigeria-prevalence-associated-risk-factors-and-assessment-of-risk-using-the-framingham-risk-score
#6
Ganiyu Amusa, Babatunde Awokola, Godsent Isiguzo, James Onuh, Samuel Uguru, David Oke, Solomon Danbauchi, Basil Okeahialam
OBJECTIVE: To evaluate the prevalence of Hypertension and associated risk factors in HIV+ adults and assessment of these risks using the Framingham risk score 'FRS'. DESIGN AND METHOD: A cross-sectional analytical study. One hundred and fifty consecutive HIV+ adults presenting at the HIV clinic of Jos University Teaching Hospital (90 on HAART) with 50 HIV- as controls were recruited. Relevant history, physical examination (including blood pressure measured according to standard guidelines), laboratory specimen (fasting plasma sugar and lipids, CD4 count and viral load) and electrocardiogram were obtained from the participants...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27350229/association-of-hiv-and-highly-active-antiretroviral-therapy-with-clinical-and-biochemical-indices-among-women-with-pre-eclampsia
#7
Niren R Maharaj, Jagidesa Moodley, Anil Chuturgoon
OBJECTIVE: To determine whether clinical and biochemical features associated with pre-eclampsia are significantly altered among women with HIV infection taking highly active antiretroviral therapy (HAART). METHODS: A prospective observational cohort study was conducted between July 2013 and September 2014 at Prince Mshiyeni Memorial Hospital, Durban, South Africa. Women with and without pre-eclampsia and HIV infection were enrolled at booking and followed up until delivery...
September 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27334566/genotypic-hiv-1-drug-resistance-among-patients-failing-tenofovir-based-first-line-haart-in-south-india
#8
Thongadi Ramesh Dinesha, Selvamurthi Gomathi, Jayaseelan Boobalan, Sathasivam Sivamalar, Sunil S Solomon, Ambrose Pradeep, Selvamuthu Poongulali, Suniti Solomon, Pachamuthu Balakrishnan, Shanmugam Saravanan
According to 2013 WHO guidelines, tenofovir (TDF) is the preferred first-line regimen for adults and adolescents. A total of 167 HIV-1-infected patients attaining immunological failure after TDF-based first-line HAART were included in this study, RT region of HIV-1 pol gene was sequenced for them, IAS-USA 2014 list and Stanford HIV drug resistance database were used for mutation interpretation. REGA V3.0 was used for HIV subtyping. The predominant NRTI and NNRTI mutations observed were M184IV (59.9%), K65R (28...
December 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27299910/-feasibility-of-cervical-smear-in-hiv-positive-women-living-in-chad
#9
E Mortier, N Doudéadoum, F Némian, A Gaulier, M Kemian
Cervical cancer is the leading cause of cancerrelated death in Sub-Saharan African women. HIV-infected women are at increased risk for cervical intraepithelial lesions and invasive cervical cancer. WHO guidelines for screening and treatment of precancerous cervical lesions are regularly actualized. There are no data on cervical squamous intraepithelial lesions in Chad. Between August 2013 and May 2015, screening for cervical squamous intraepithelial lesions was proposed to HIV-infected women living in Moundou (Chad)...
August 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27271083/time-to-haart-initiation-after-diagnosis-and-treatment-of-opportunistic-infections-in-patients-with-aids-in-latin-america
#10
Brenda Crabtree-Ramírez, Yanink Caro-Vega, Bryan E Shepherd, Beatriz Grinsztejn, Marcelo Wolff, Claudia P Cortes, Denis Padgett, Gabriela Carriquiry, Valeria Fink, Karu Jayathilake, Anna K Person, Catherine McGowan, Juan Sierra-Madero
BACKGROUND: Since 2009, earlier initiation of highly active antiretroviral therapy (HAART) after an opportunistic infection (OI) has been recommended based on lower risks of death and AIDS-related progression found in clinical trials. Delay in HAART initiation after OIs may be an important barrier for successful outcomes in patients with advanced disease. Timing of HAART initiation after an OI in "real life" settings in Latin America has not been evaluated. METHODS: Patients in the Caribbean, Central and South America network for HIV Epidemiology (CCASAnet) ≥18 years of age at enrolment, from 2001-2012 who had an OI before HAART initiation were included...
2016: PloS One
https://www.readbyqxmd.com/read/27232874/late-hiv-testing-in-a-cohort-of-hiv-infected-patients-in-puerto-rico
#11
Katherine Y Tossas-Milligan, Robert F Hunter-Mellado, Angel M Mayor, Diana M Fernández-Santos, Mark S Dworkin
OBJECTIVE: Late HIV testing (LT), defined as receiving an AIDS diagnosis within a year of one's first positive HIV test, is associated with higher HIV transmission, lower HAART effectiveness, and worse outcomes. Latinos represent 36% of LT in the US, yet research concerning LT among HIV cases in Puerto Rico is scarce. METHODS: Multivariable logistic regression analysis was used to identify factors associated with LT, and a Cochran‒Armitage test was used to determine LT trends in an HIV-infected cohort followed at a clinic in Puerto Rico specialized in the management and treatment of HIV...
May 24, 2016: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/27089861/high-frequency-of-neurosyphilis-in-hiv-positive-patients-diagnosed-with-early-syphilis
#12
E Firlag-Burkacka, P Swiecki, I Cielniak, E Siwak, J Gizinska, E Bakowska, J Kubicka, P Pulik, J Kowalski, R Podlasin, A Horban
BACKGROUND: Syphilis is an infection frequently seen with HIV, and European guidelines on the management of syphilis suggest that HIV-infected patients may have an increased risk of early neurological involvement, sometimes asymptomatic. Recent study shows a relationship between neurosyphilis and cerebrospinal fluid (CSF) HIV viral load (VL), which in turn may be associated with subsequent neurocognitive decline. OBJECTIVES AND METHODS: The aim of the study was estimation of the frequency of neurosyphilis among HIV-positive patients with early syphilis...
May 2016: HIV Medicine
https://www.readbyqxmd.com/read/27009401/a-regional-drug-and-therapeutics-committee-led-intervention-to-reduce-the-hospital-costs-of-expensive-hiv-drugs
#13
Camilla Munk Mikkelsen, Stig Ejdrup Andersen
In 2009, the regional Drug and Therapeutics Committee (DTC) began a series of meetings with lead specialists in infectious diseases. The role of the DTC was to engage clinicians and ensure commitment to prescribing the least expensive drugs among the clinically equivalent HAARTs (highly active antiretroviral therapy). DTC also led implementation of a national guideline. This study analyses the impact of this process on HAART consumption and expenditure. The HAART consumption and expenditure (2009-2013) was compared to forecasts produced by exponential smoothing (2004-2009)...
September 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/26910597/recent-insights-into-cardiovascular-disease-cvd-risk-among-hiv-infected-adults
#14
Robert C Kaplan, David B Hanna, Jorge R Kizer
While mortality rates related to cardiovascular disease (CVD) have decreased over time among adults with HIV, excess risk of CVD in the HIV-infected population may persist despite highly active antiretroviral therapy (HAART) treatment and aggressive CVD risk factor control. Beyond atherosclerotic CVD, recent studies suggest that HIV infection may be associated with left ventricular systolic and diastolic function, interstitial myocardial fibrosis, and increased cardiac fat infiltration. Thus, with the increasing average age of the HIV-infected population, heart failure and arrhythmic disorders may soon rival coronary artery disease as the most prevalent forms of CVD...
February 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/26880101/sexually-transmitted-infections-and-use-of-contraceptives-in-women-living-with-hiv-in-denmark-the-shade-cohort
#15
MULTICENTER STUDY
Kristina Thorsteinsson, Steen Ladelund, Merete Storgaard, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lars Nørregård Nielsen, Jesper Bonde, Henrik Westh, Niels Obel, Terese L Katzenstein, Anne-Mette Lebech
BACKGROUND: No Danish guidelines for screening of sexually transmitted infections (STIs) in women living with HIV (WLWH) exist, except for annual syphilis testing. Drug-drug interaction between hormonal contraceptives and some types of highly active antiretroviral therapy (HAART) occurs. We assessed prevalence of STIs, contraceptive choices and predictors of condom use in a cohort of WLWH in Denmark. METHODS: WLWH consecutively enrolled during their outpatient visits from 2011 to 2012...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26788407/the-incidence-and-clinical-characteristics-of-acute-serum-creatinine-elevation-more-than-1-5-mg-dl-among-the-patients-treated-with-tenofovir-emtricitabine-containing-haart-regimens
#16
Sun Jin, Myung Hi Kim, Jung Hwa Park, Hye Jin Jung, Hye Jin Lee, Shin-Woo Kim, Jong Myung Lee, Sujeong Kim, Hyun-Ha Chang
BACKGROUND: The combination of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) has been the first choice nucleoside reverse transcriptase inhibitor (NRTI) according to many reliable antiretroviral treatment (ART) guidelines because of its high efficacy. However, TDF-related renal toxicity reported in Western countries is a challenging issue regarding clinical use. We conducted this study to evaluate the incidence and characteristics of an acute increase in serum creatinine (Cr) level > 1...
December 2015: Infection & Chemotherapy
https://www.readbyqxmd.com/read/26525557/maternal-highly-active-antiretroviral-therapy-and-child-hiv-free-survival-in-malawi-2004-2009
#17
Sheree R Schwartz, Newton Kumwenda, Johnstone Kumwenda, Shu Chen, Lynne M Mofenson, Allan W Taylor, Mary Glenn Fowler, Taha E Taha
OBJECTIVES: Highly active antiretroviral therapy (HAART) provision to eligible HIV-infected pregnant and post-partum women is critical for optimizing maternal health. We assessed the impact of maternal HAART on HIV-free survival of breastfed infants in Malawi. METHODS: The post-exposure prophylaxis of infants-Malawi trial (2004-2009) enrolled mothers/infants during labor or immediately post-partum to evaluate 14-week extended infant antiretroviral prophylaxis for preventing HIV transmission through breastfeeding...
March 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/26356739/late-hiv-testing-in-a-cohort-of-hiv-infected-patients-in-puerto-rico
#18
Katherine Y Tossas-Milligan, Robert F Hunter-Mellado, Angel M Mayor, Diana M Fernández-Santos, Mark S Dworkin
OBJECTIVE: Late HIV testing (LT), defined as receiving an AIDS diagnosis within a year of one's first positive HIV test, is associated with higher HIV transmission, lower HAART effectiveness, and worse outcomes. Latinos represent 36% of LT in the US, yet research concerning LT among HIV cases in Puerto Rico is scarce. METHODS: Multivariable logistic regression analysis was used to identify factors associated with LT, and a Cochran‒Armitage test was used to determine LT trends in an HIV-infected cohort followed at a clinic in Puerto Rico specialized in the management and treatment of HIV...
September 2015: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/26316787/a-narrative-review-of-cost-effectiveness-analysis-of-people-living-with-hiv-treated-with-haart-from-interventions-to-outcomes
#19
REVIEW
Wah Fung Tse, Weimin Yang, Wenlong Huang
BACKGROUND: Since its introduction in 1996, highly active antiretroviral therapy (HAART), which involves the combination of antiretroviral drugs, has resulted in significant improvements in the morbidity, mortality, and life expectancy of HIV-infected patients. Numerous studies of the cost-effectiveness of HAART from different perspectives in HIV have been reported. AIM: To investigate the economic outcomes and relevance of HAART for people living with HIV. MATERIALS AND METHODS: A narrative literature review was conducted on 22 peer-reviewed full economic evaluations of people living with HIV treated with different HAART regimens and published in English between January 2005 and December 2014...
2015: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/26280669/a-clinical-algorithm-to-identify-hiv-patients-at-high-risk-for-incident-active-tuberculosis-a-prospective-5-year-cohort-study
#20
Susan Shin-Jung Lee, Hsi-Hsun Lin, Hung-Chin Tsai, Ih-Jen Su, Chin-Hui Yang, Hsin-Yun Sun, Chien-Chin Hung, Cheng-Len Sy, Kuan-Sheng Wu, Jui-Kuang Chen, Yao-Shen Chen, Chi-Tai Fang
BACKGROUND: Predicting the risk of tuberculosis (TB) in people living with HIV (PLHIV) using a single test is currently not possible. We aimed to develop and validate a clinical algorithm, using baseline CD4 cell counts, HIV viral load (pVL), and interferon-gamma release assay (IGRA), to identify PLHIV who are at high risk for incident active TB in low-to-moderate TB burden settings where highly active antiretroviral therapy (HAART) is routinely provided. MATERIALS AND METHODS: A prospective, 5-year, cohort study of adult PLHIV was conducted from 2006 to 2012 in two hospitals in Taiwan...
2015: PloS One
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