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Bipolar misdiagnosis

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https://www.readbyqxmd.com/read/29736129/analysis-of-misdiagnosis-of-bipolar-disorder-in-an-outpatient-setting
#1
Hui Shen, Li Zhang, Chuchen Xu, Jinling Zhu, Meijuan Chen, Yiru Fang
Background: Bipolar disorder is a mental illness with a high misdiagnosis rate and commonly misdiagnosed as other mental disorders including depression, schizophrenia, anxiety disorders, obsessive-compulsive disorders, and personality disorders, resulting in the mistreatment of clinical symptoms and increasing of recurrent episodes. Aims: To understand the reasons for misdiagnosis of bipolar disorder in an outpatient setting in order to help clinicians more clearly identify the disease and avoid diagnostic errors...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29734005/complexity-analysis-of-spontaneous-brain-activity-in-mood-disorders-a-magnetoencephalography-study-of-bipolar-disorder-and-major-depression
#2
Alberto Fernández, Ali H Al-Timemy, Francisco Ferre, Gabriel Rubio, Javier Escudero
BACKGROUND AND PURPOSE: The lack of a biomarker for Bipolar Disorder (BD) causes problems in the differential diagnosis with other mood disorders such as major depression (MD), and misdiagnosis frequently occurs. Bearing this in mind, we investigated non-linear magnetoencephalography (MEG) patterns in BD and MD. METHODS: Lempel-Ziv Complexity (LZC) was used to evaluate the resting-state MEG activity in a cross-sectional sample of 60 subjects, including 20 patients with MD, 16 patients with BD type-I, and 24 control (CON) subjects...
April 26, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29656268/the-development-and-validation-of-a-short-version-of-the-33-item-hypomania-checklist-hcl-33
#3
Yuan-Yuan Wang, Yuan Feng, Dan-Dan Xu, Wei Huang, Ines H I Chow, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Gang Wang, Yu-Tao Xiang
BACKGROUND: The misdiagnosis of bipolar disorder (BD) as major depressive disorder (MDD) is common in clinical practice and may result in inappropriate treatment. The 33-item Hypomania Checklist (HCL-33) is a newly developed screening scale for BD with satisfactory psychometric properties. In this study, a short version of the HCL-33 was developed and validated to discriminate between BD and MDD. METHOD: All interviews were conducted in a major psychiatric hospital in China...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29527766/racial-disparities-in-bipolar-disorder-treatment-and-research-a-call-to-action
#4
REVIEW
Margaret O Akinhanmi, Joanna M Biernacka, Stephen M Strakowski, Susan L McElroy, Joyce E Balls Berry, Kathleen R Merikangas, Shervin Assari, Melvin G McInnis, Thomas G Schulze, Marion LeBoyer, Carol Tamminga, Christi Patten, Mark A Frye
OBJECTIVES: Health disparities between individuals of African and European ancestry are well documented. The disparities in bipolar disorder may be driven by racial bias superimposed on established factors contributing to misdiagnosis, including: evolving empirically based diagnostic criteria (International Classification of Diseases [ICD], Research Diagnostic Criteria [RDC] and Diagnostic and Statistical Manual [DSM]), multiple symptom domains (i.e. mania, depression and psychosis), and multimodal medical and additional psychiatric comorbidity...
March 12, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29478517/metabolomics-of-major-depressive-disorder-and-bipolar-disorder-overview-and-future-perspective
#5
Kenji Hashimoto
Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their shared clinical features result in high rates of misdiagnosis due to a lack of biomarkers that allow their differentiation. BD is more frequently misdiagnosed as MDD because of overlapping symptomology, often later onset of mania, and frequent occurrence of depressive episodes in patients with BD. Misdiagnosis is also increased when patients with BD present symptoms indicative of a clinically significant depressive episode, but are premorbid for manic symptoms, or previous manic states not recognized...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29350128/between-a-rock-a-bye-and-a-hard-place-mood-disorders-during-the-peripartum-period
#6
Michael Thomson, Verinder Sharma
Mood disorders including major depressive disorder and bipolar disorder are common during and after pregnancy. Timely identification and appropriate management of mood episodes is essential to maximize maternal well-being and minimize adverse outcomes. Failure to do so results in maternal suffering and impaired child bonding, and has the potential for devastating outcomes including suicide and infanticide. Women are routinely screened for unipolar depression during or after pregnancy but not for bipolar disorder, in spite of the fact that childbirth is associated with a major risk for onset or exacerbation of bipolar disorder...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29075118/the-comorbidity-of-bipolar-disorder-diabetes-mellitus-and-autoimmune-hypothyroidism-in-an-adult-woman-with-turner-s-syndrome-a-case-report
#7
Jinling Li, Xiaohong Hong, Haiyun Xu
Turner's syndrome (TS) is the most common sex chromosome abnormality in females and characterized with short stature and ovarian dysgenesis. Patients with TS may also present many other physical diseases and mental disorders. In this case report, we present a 49-year-old woman with TS, who also met criteria for bipolar disorder, type 2 diabetes mellitus, and autoimmune hypothyroidism. The patient was admitted to the mental health center for depressive symptoms in 1991 and was misdiagnosed as hypopituitarism, which was not corrected until 2005 when her karyotype of 45, X/46, X, i(Xq) was identified...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28811911/evaluation-of-the-13-item-hypomania-checklist-and-a-brief-3-item-manic-features-questionnaire-in-primary-care
#8
Sukhmeet Singh, Paul Scouller, Daniel J Smith
Aims and method The mean delay for bipolar disorder diagnosis is 10 years. Identification of patients with previous hypomania is challenging, sometimes resulting in misdiagnosis. The aims of this study were: (a) to estimate the proportion of primary care patients with depression currently taking antidepressants who have undiagnosed bipolar disorder and (b) to compare a brief 3-item manic features questionnaire with the Hypomania Checklist (HCL-13). The sample comprised patients with a recorded diagnosis of depression, either on long-term antidepressant therapy or with previous multiple courses of antidepressants...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28574009/potential-biomarkers-for-bipolar-disorder-where-do-we-stand
#9
REVIEW
Rajesh Sagar, Raman Deep Pattanayak
Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28515562/leukodystrophy-presenting-as-hyperactivity-and-bipolarity-with-uncommon-adverse-drug-reaction
#10
Roshan Sutar, Anirban Ray, Shekhar P Sheshadri
Leukodystrophy is a group of demyelinating neurodegenerative diseases of brain with varied presentation and multiple etiologies. Prognosis is predominantly dismal. Misdiagnosis and wrong treatment are common in this group of rare neurological disorders, especially when it presents with psychiatric symptoms. In this case, importance of neurological and radiological evaluation and need for high diagnostic suspicion in treatment-resistant psychiatric disorders is highlighted.
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28365522/longitudinal-course-and-characteristics-of-cyclothymic-disorder-in-youth
#11
Anna R Van Meter, Eric A Youngstrom, Boris Birmaher, Mary A Fristad, Sarah M Horwitz, Thomas W Frazier, L Eugene Arnold, Robert L Findling
OBJECTIVES: Epidemiological studies suggest that cyclothymic disorder is the most prevalent subtype of bipolar disorder (BD). However, it is rarely diagnosed, especially in youth. This may be because it can be difficult to ascertain whether a youth meets diagnostic criteria. Clearer, easy-to-apply criteria could reduce misdiagnosis. The objective oftable this study was to determine whether proposed research diagnostic criteria for cyclothymic disorder (RDCyc), based on DSM-5 criteria, could be quantified and validated in youth...
June 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28327583/duration-of-untreated-bipolar-disorder-a-multicenter-study
#12
Ling Zhang, Xin Yu, Yi-Ru Fang, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Hui-Chun Li, Hai-Chen Yang, Qing-Rong Tan, Xiu-Feng Xu, Gang Wang, Yu-Tao Xiang
Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features of short (≤2 years) and long DUB (>2 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) was examined in 7 psychiatric hospitals and general hospital psychiatric units across China. Patients' demographic and clinical characteristics were collected using a standardized protocol and data collection procedure...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239946/a-voxel-based-diffusion-tensor-imaging-study-in-unipolar-and-bipolar-depression
#13
Jonathan Repple, Susanne Meinert, Dominik Grotegerd, Harald Kugel, Ronny Redlich, Katharina Dohm, Dario Zaremba, Nils Opel, Christian Buerger, Katharina Förster, Theresa Nick, Volker Arolt, Walter Heindel, Michael Deppe, Udo Dannlowski
OBJECTIVE: The absence of neurobiological diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We investigated if changes in fractional anisotropy (FA) could help to differentiate BD from UD in the state of depression. METHODS: Using diffusion tensor imaging (DTI) we employed a voxel-based analysis approach to examine fractional anisotropy (FA) in 86 patients experiencing an acute major depressive episode according to DSM-IV (N=39 BD, mean age 39...
February 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28044944/a-pragmatic-approach-to-the-diagnosis-and-treatment-of-mixed-features-in-adults-with-mood-disorders
#14
Roger S McIntyre, Yena Lee, Rodrigo B Mansur
Mixed features specifier (MFS) is a new nosological entity defined and operationalized in the Diagnostic and Statistical Manual of Mental Disorders (DSM), 5th Edition. The impetus to introduce the MFS and supplant mixed states was protean, including the lack of ecological validity, high rates of misdiagnosis, and guideline discordant treatment for mixed states. Mixed features specifier identifies a phenotype in psychiatry with greater illness burden, as evidenced by earlier age at onset, higher episode frequency and chronicity, psychiatric and medical comorbidity, suicidality, and suboptimal response to conventional antidepressants...
December 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27822021/time-to-lack-of-persistence-with-pharmacological-treatment-among-patients-with-current-depressive-episodes-a-natural-study-with-1-year-follow-up
#15
Kanglai Li, Qinling Wei, Guanying Li, Xiangjun He, Yingtao Liao, Zhaoyu Gan
INTRODUCTION: Medication nonadherence remains a big challenge for depressive patients. This study aims to assess and compare the medication persistence between unipolar depression (UD) and bipolar depression (BD). METHODS: A total of 146 UD and 187 BD patients were recruited at their first index prescription. Time to lack of persistence with pharmacological treatment (defined as a gap of at least 60 days without taking any medication) was calculated, and clinical characteristics were collected...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27663811/are-ssris-responsible-for-precipitating-suicidal-ideation-in-teenagers-with-subsyndromal-bipolar-affective-disorder-who-have-been-misdiagnosed-with-unipolar-depression
#16
Stephen Hogg, Sereena Ansari, Qasim Masood, Mark Agius, Zoltan Rihmer
Concerns have recently been raised about a possible link between suicidal ideation and the use of SSRIs in teenagers diagnosed with unipolar depression, such that the USA FDA and UK CSM have issued warnings regarding the use of SSRIs in adolescents with depression. We investigated this phenomenon first by recognizing that the initial presentation of unipolar and bipolar depression may only differ in subtle ways and with the result being that a significant number of patients are misdiagnosed at the expense of patient outcomes...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27624425/contribution-of-long-duration-of-undiagnosed-bipolar-disorder-to-high-frequency-of-relapse-a-naturalistic-study-in-china
#17
MULTICENTER STUDY
Wu Hong, Chen Zhang, Meng Juan Xing, Dai Hui Peng, Zhi Guo Wu, Zuo Wei Wang, Jun Chen, Cheng Mei Yuan, You Song Su, Ying Yan Hu, Lan Cao, Yong Wang, Jia Huang, Wei Hong Lu, Zheng Hui Yi, Xin Yu, Jing Ping Zhao, Qinting Zhang, Yi Ru Fang
BACKGROUND: With attention to misdiagnosis of bipolar disorder (BP), long duration of undiagnosed bipolar disorder (DUBP) had been reported recently in years. This study aims to investigate the contributions of long DUBP to the frequency of relapse in bipolar patients, and explore affect factors of DUBP. METHOD: From 26 hospitals throughout China, 3896 participants diagnosed with BP according to International Classification of Diseases 10th criteria were enrolled in this study...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27613282/ratio-of-mbdnf-to-probdnf-for-differential-diagnosis-of-major-depressive-disorder-and-bipolar-depression
#18
Guoqing Zhao, Chen Zhang, Jun Chen, Yousong Su, Rubai Zhou, Fan Wang, Weiping Xia, Jia Huang, Zuowei Wang, Yingyan Hu, Lan Cao, Xiaoyun Guo, Chengmei Yuan, Yong Wang, Zhenghui Yi, Weihong Lu, Yan Wu, Zhiguo Wu, Wu Hong, Daihui Peng, Yiru Fang
There is a high rate of misdiagnosis between major depressive disorder (MDD) and bipolar disorder (BD) in clinical practice. Our previous work provided suggestive evidence for brain-derived neurotrophic factor (BDNF) in differentiating BD from MDD. In this study, we aimed to investigate the role of mature BDNF (mBDNF) and its precursor (proBDNF) in distinguishing bipolar depression (BP) from MDD during acute depressive episode. A total of 105 participants, including 44 healthy controls, 37 MDD patients and 24 BP patients, were recruited...
September 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/27601906/disruptive-mood-dysregulation-disorder-current-insights
#19
REVIEW
Raman Baweja, Susan D Mayes, Usman Hameed, James G Waxmonsky
Disruptive mood dysregulation disorder (DMDD) was introduced as a new diagnostic entity under the category of depressive disorders in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). It was included in DSM-5 primarily to address concerns about the misdiagnosis and consequent overtreatment of bipolar disorder in children and adolescents. DMDD does provide a home for a large percentage of referred children with severe persistent irritability that did not fit well into any DSM, Fourth Edition (DSM-IV) diagnostic category...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27347256/advanced-practice-registered-nurses-gateway-to-screening-for-bipolar-disorder-in-primary-care
#20
Ann Marie Kriebel-Gasparro
OBJECTIVE: The goal of this mixed methods descriptive study was to explore Advanced Practice Registered Nurses' (APRNs') knowledge of bipolar disorder (BPD) and their perceptions of facilitators and barriers to screening patients with known depression for BPD. METHODS: A mixed method study design using surveys on BPD knowledge and screening practices as well as focus group data collection method for facilitators and barriers to screening. RESULTS: 89 APRNs completed the survey and 12 APRNs participated in the focus groups...
2016: Open Nursing Journal
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