keyword
MENU ▼
Read by QxMD icon Read
search

Categorical approach

keyword
https://www.readbyqxmd.com/read/29341346/a-systematic-review-and-classification-of-interventions-for-speech-sound-disorder-in-preschool-children
#1
REVIEW
Yvonne Wren, Sam Harding, Juliet Goldbart, Sue Roulstone
BACKGROUND: Multiple nterventions have been developed to address speech sound disorder (SSD) in children. Many of these have been evaluated but the evidence for these has not been considered within a model which categorizes types of intervention. The opportunity to carry out a systematic of interventions for SSD arose as part of a larger scale study of interventions for primary speech and language impairment in preschool children. AIMS: To review systematically the evidence for interventions for SSD in preschool children and to categorize them within a classification of interventions for SSD...
January 16, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29340527/cardiac-protein-expression-patterns-are-associated-with-distinct-inborn-exercise-capacity-in-non-selectively-bred-rats
#2
L P Ribeiro, L C Freitas-Lima, G B Naumann, S S Meyrelles, W Lunz, S F Pires, H M Andrade, J B T Carnielli, S G Figueiredo
In the present study, we successfully demonstrated for the first time the existence of cardiac proteomic differences between non-selectively bred rats with distinct intrinsic exercise capacities. A proteomic approach based on two-dimensional gel electrophoresis coupled to mass spectrometry was used to study the left ventricle (LV) tissue proteome of rats with distinct intrinsic exercise capacity. Low running performance (LRP) and high running performance (HRP) rats were categorized by a treadmill exercise test, according to distance run to exhaustion...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29340148/reducing-unnecessary-culturing-a-systems-approach-to-evaluating-urine-culture-ordering-and-collection-practices-among-nurses-in-two-acute-care-settings
#3
Robert Redwood, Mary Jo Knobloch, Daniela C Pellegrini, Matthew J Ziegler, Michael Pulia, Nasia Safdar
Background: Inappropriate ordering and acquisition of urine cultures leads to unnecessary treatment of asymptomatic bacteriuria (ASB). Treatment of ASB contributes to antimicrobial resistance particularly among hospital-acquired organisms. Our objective was to investigate urine culture ordering and collection practices among nurses to identify key system-level and human factor barriers and facilitators that affect optimal ordering and collection practices. Methods: We conducted two focus groups, one with ED nurses and the other with ICU nurses...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29339530/management-of-endocrine-disease-personalized-medicine-in-the-treatment-of-acromegaly
#4
Leandro Kasuki, Luiz Eduardo Wildemberg, Monica R Gadelha
Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-generation somatostatin receptor ligands (fg-SRL) are initiated for most patients, although approximately 25% of patients present resistance to this drug class. Some biomarkers of treatment outcome are described in the literature, with the aim of categorizing patients into different groups to individualize their treatments using a personalized approach...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29339515/mers-cov-and-h5n1-influenza-virus-antagonize-antigen-presentation-by-altering-the-epigenetic-landscape
#5
Vineet D Menachery, Alexandra Schäfer, Kristin E Burnum-Johnson, Hugh D Mitchell, Amie J Eisfeld, Kevin B Walters, Carrie D Nicora, Samuel O Purvine, Cameron P Casey, Matthew E Monroe, Karl K Weitz, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Lisa E Gralinski, Thomas O Metz, Richard D Smith, Katrina M Waters, Amy C Sims, Yoshihiro Kawaoka, Ralph S Baric
Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ-dependent genes following infection with robust respiratory viruses including influenza viruses [A/influenza/Vietnam/1203/2004 (H5N1-VN1203) and A/influenza/California/04/2009 (H1N1-CA04)] and coronaviruses [severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV)]...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29337760/using-thresholds-in-noise-to-identify-hidden-hearing-loss-in-humans
#6
Courtney L Ridley, Judy G Kopun, Stephen T Neely, Michael P Gorga, Daniel M Rasetshwane
OBJECTIVES: Recent animal studies suggest that noise-induced synaptopathy may underlie a phenomenon that has been labeled hidden hearing loss (HHL). Noise exposure preferentially damages low spontaneous-rate auditory nerve fibers, which are involved in the processing of moderate- to high-level sounds and are more resistant to masking by background noise. Therefore, the effect of synaptopathy may be more evident in suprathreshold measures of auditory function, especially in the presence of background noise...
January 15, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29337662/studies-of-transgenic-mosquitoes-in-disease-endemic-countries-preparation-of-containment-facilities
#7
M Megan Quinlan, James Mutuku Mutunga, Abdoulaye Diabaté, Moussa Namountougou, Mamadou B Coulibaly, Lakamy Sylla, Jonathan Kayondo, Victor Balyesima, Lorna Clark, Mark Q Benedict, Peter Raymond
Novel approaches to area-wide control of vector species offer promise as additional tools in the fight against vectored diseases. Evaluation of transgenic insect strains aimed at field population control in disease-endemic countries may involve international partnerships and should be done in a stepwise approach, starting with studies in containment facilities. The preparations of both new-build and renovated facilities are described, including working with local and national regulations regarding land use, construction, and biosafety requirements, as well as international guidance to fill any gaps in regulation...
January 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29337084/a-graph-based-approach-to-analyze-flux-balanced-pathways-in-metabolic-networks
#8
Mona Arabzadeh, Morteza Saheb Zamani, Mehdi Sedighi, Sayed-Amir Marashi
An Elementary Flux Mode (EFM) is a pathway with minimum set of reactions that are functional in steady-state constrained space. Due to the high computational complexity of calculating EFMs, different approaches have been proposed to find these flux-balanced pathways. In this paper, an approach to find a subset of EFMs is proposed based on a graph data model. The given metabolic network is mapped to the graph model and decisions for reaction inclusion can be made based on metabolites and their associated reactions...
January 11, 2018: Bio Systems
https://www.readbyqxmd.com/read/29337014/the-anatomic-analysis-of-the-vidian-canal-and-the-surrounding-structures-concerning-vidian-neurectomy-using-computed-tomography-scans
#9
Gülay Açar, Aynur Emine Çiçekcibaşı, İbrahim Çukurova, Kemal Emre Özen, Muzaffer Şeker, İbrahim Güler
INTRODUCTION: The type of endoscopic approach chosen for vidian neurectomy can be specified by evaluating the vidian canal and the surrounding sphenoid sinus structures. OBJECTIVE: The variations and morphometry of the vidian canal were investigated, focusing on the functional correlations between them which are crucial anatomical landmarks for preoperative planning. METHODS: This study was performed using paranasal multidetector computed tomography images that were obtained with a section thickening of 0...
December 26, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29336268/%C3%AE-naplastic-lymphoma-kinase-in-glioblastoma-detection-diagnostic-methods-and-therapeutic-options
#10
Theodosis Kalamatianos, Despoina Denekou, George Stranjalis, Evangelia Papadimitriou
BACKGROUND: Glioblastoma (GBM) is the most aggressive and common brain tumor in adults, currently lacking effective life-prolonging and recurrence-preventing therapy; median survival of GBM patients stands at only 14-16 months. Increasing lines of evidence indicate that Anaplastic lymphoma kinase (ALK), a druggable tyrosine kinase receptor over-expressed in GBM, represents a potential therapeutic target in this tumor. OBJECTIVE: An overview of the state of the art and the existing recent patents regarding potential exploitation of ALK as a therapeutic target and/or diagnostic/prognostic factor in GBM...
January 15, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29335874/mass-balance-of-arsenic-fluxes-in-rivers-impacted-by-gold-mining-activities-in-paracatu-minas-gerais-state-brazil
#11
Edison Bidone, Ricardo Cesar, Maria Carla Santos, Ricardo Sierpe, Emmanuel Vieira Silva-Filho, Vinicius Kutter, Lílian I Dias da Silva, Zuleica Castilhos
Arsenic (As) is a dangerous and carcinogenic element and drinking water is its main pathway of human exposure. Gold mines are widely recognized as important sources of As pollution. This work proposes the assessment of As distribution along watersheds surrounding "Morro do Ouro" gold mine (Paracatu, southeastern Brazil). A balance approach between filtered As fluxes (As < 0.45 μm) and suspended particulate material (AsSPM) in different river segments was applied. Ultrafiltration procedure was used to categorize As into the following classes: particulate > 0...
January 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29334187/surveying-the-landscape-of-optogenetic-methods-for-detection-of-protein-protein-interactions
#12
REVIEW
Matthew D Wiens, Robert E Campbell
Mapping the protein-protein interaction (PPi) landscape is of critical importance to furthering our understanding how cells and organisms function. Optogenetic methods, that is, approaches that utilize genetically encoded fluorophores or fluorogenic enzyme reactions, uniquely enable the visualization of biochemical phenomena in live cells with high spatial and temporal accuracy. Applying optogenetic methods to the detection of PPis requires the engineering of protein-based systems in which an optical signal undergoes a substantial change when the two proteins of interest interact...
January 15, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29333729/immunoengineering-with-biomaterials-for-enhanced-cancer-immunotherapy
#13
REVIEW
Yu-Qing Xie, Lixia Wei, Li Tang
Cancer immunotherapy has recently shown dramatic clinical success inducing durable response in patients of a wide variety of malignancies. Further improvement of the clinical outcome with immune related cancer treatment requests more exquisite manipulation of a patient's immune system with increased immunity against diseases while mitigating the toxicities. To meet this challenge, biomaterials applied to immunoengineering are being developed to achieve tissue- and/or cell-specific immunomodulation and thus could potentially enhance both the efficacy and safety of current cancer immunotherapies...
January 14, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29330239/one-year-of-family-physicians-observations-on-working-with-medical-scribes
#14
Amelia Sattler, Tracy Rydel, Cathina Nguyen, Steven Lin
PURPOSE: The immense clerical burden felt by physicians is one of the leading causes of burnout. Scribes are increasingly being used to help alleviate this burden, yet few published studies investigate how scribes affect physicians' daily work, attitudes and behaviors, and relationships with patients and the workplace. METHODS: Using a longitudinal observational design, data were collected, over 1 year, from 4 physicians working with 2 scribes at a single academic family medicine practice...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29327248/introducing-new-technology-safely-into-urological-practice
#15
Siska Van Bruwaene, Benjamin Namdarian, Ben Challacombe, Ben Eddy, Ignace Billiet
PURPOSE: Surgical innovation is necessary to ensure continued improvement in patient care. However, several challenges unique to the surgical craft are encountered during the development and validation of such new technology. This article highlights some of these challenges and gives an overview of existing solutions. METHODS: A Pubmed review was performed about the "introduction of new technology" to identify challenges. Cross-referencing was used to explore the possible solutions per challenge...
January 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29325879/ovarian-control-and-monitoring-in-amphibians
#16
N E Calatayud, M Stoops, B S Durrant
Amphibian evolution spans over 350 million years ago, consequently this taxonomic group displays a wide, complex array of physiological adaptations and their diverse modes of reproduction are a prime example. Reproduction can be affected by taxonomy, geographic and altitudinal distribution, and environmental factors. With some exceptions, amphibians can be categorized into discontinuous (strictly seasonal) and continuous breeders. Temperature and its close association with other proximate and genetic factors control reproduction via a tight relationship with circadian rhythms which drive genetic and hormonal responses to the environment...
December 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29325833/treatment-of-graves-disease-in-children-the-portuguese-experience
#17
Olinda Marques, Ana Antunes, Maria João Oliveira
INTRODUCTION: Graves' disease (GD) is an autoimmune thyroid disease, common in adults but rare in children. The best therapeutic approach remains controversial. OBJECTIVES: To ascertain the current treatment of pediatric GD in Portugal and to assess the clinical and biochemical factors that determine definitive/long-term remission after treatment with antithyroid drugs (ATDs). PATIENTS AND METHODS: A retrospective analysis of data about pediatric GD treatment collected from a nationwide survey conducted by the Portuguese Society of Pediatric Endocrinology and Diabetology from May to August 2013...
January 8, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29324604/preterm-birth-and-gestational-length-in-four-race-nativity-groups-including-somali-americans
#18
Emily A Oliver, Mark Klebanoff, Lina Yossef-Salameh, Reena Oza-Frank, Soheil Moosavinasab, Patricia Reagan, Louis Muglia, Catalin S Buhimschi, Irina A Buhimschi
OBJECTIVE: To compare preterm birth rates and gestational length in four race-nativity groups including Somali Americans. METHODS: Using a retrospective cohort study design of Ohio birth certificates, we analyzed all singleton births between 2000 and 2015 from four groups of women categorized as U.S.-born, non-Hispanic white (USBW), U.S.-born, non-Hispanic black (USBB), African-born black (ABB, primarily of West African birth country), and Somalia-born (SB). An algorithm trained on maternal names was used to confirm Somali ethnicity...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29323408/prediction-analysis-and-quality-assessment-of-microwell-array-images
#19
Hirak Mazumdar, Tae Hyeon Kim, Jong Min Lee, Jang Ho Ha, Christian D Ahrberg, Bong Geun Chung
Microwell arrays are widely used sensor for the analysis of fluorescent-labelled biomaterials. For rapid detection and automated analysis of microwell arrays, the computational image analysis is required. Support Vector Machines (SVM) can be used for this task. Here, we present a SVM-based approach for the analysis of microwell arrays consisting of three distinct steps: labeling, training for feature selection, and classification into three classes. The three classes are filled, partially filled, and unfilled microwells...
January 11, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29321077/social-anxiety-disorder-looking-back-and-moving-forward
#20
Matthew P Hyett, Peter M McEvoy
Fifty years have passed since social anxiety disorder (SAD) was first differentiated from other phobias. In the years since research has largely aligned with the zeitgeist of categorical classificatory frameworks, and has spanned identifying causes, maintenance factors and innovative interventions. Despite significant advances in the field, the capacity to conceptualise SAD as an independent entity is limited given the heterogeneity and dimensionality of diagnostic criteria, high rates of comorbidity, and non-specificity of aetiological mechanisms, maintaining factors and approaches to treatment...
January 11, 2018: Psychological Medicine
keyword
keyword
88057
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"