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https://www.readbyqxmd.com/read/28918194/cleaning-and-asthma-a-systematic-review-and-approach-for-effective-safety-assessment
#1
Melissa J Vincent, Ann Parker, Andrew Maier
Research indicates a correlative relationship between asthma and use of consumer cleaning products. We conduct a systematic review of epidemiological literature on persons who use or are exposed to cleaning products, both in occupational and domestic settings, and risk of asthma or asthma-like symptoms to improve understanding of the causal relationship between exposure and asthma. A scoring method for assessing study reliability is presented. Although research indicates an association between asthma and the use of cleaning products, no study robustly investigates exposure to cleaning products or ingredients along with asthma risk...
September 13, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28916935/risk-stratification-model-lower-extremity-ultrasonography-for-hospitalized-patients-with-suspected-deep-vein-thrombosis
#2
Emily C Alper, Ivan K Ip, Patricia Balthazar, Gregory Piazza, Samuel Z Goldhaber, Carol B Benson, Ronilda Lacson, Ramin Khorasani
BACKGROUND: The Wells score for deep venous thrombosis (DVT) has a high failure rate and low efficiency among inpatients. OBJECTIVE: To create and validate an inpatient-specific risk stratification model to help assess pre-test probability of DVT in hospitalized patients. DESIGN: Prospective cohort study of hospitalized patients undergoing lower-extremity ultrasonography studies (LEUS) for suspected DVT. Demographics, physical findings, medical history, medications, hospitalization, and laboratory and imaging results were collected...
September 15, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28915874/unmet-needs-in-the-treatment-of-idiopathic-pulmonary-fibrosis-insights-from-patient-chart-review-in-five-european-countries
#3
Toby M Maher, Maria Molina-Molina, Anne-Marie Russell, Francesco Bonella, Stéphane Jouneau, Elena Ripamonti, Judit Axmann, Carlo Vancheri
BACKGROUND: Two antifibrotic drugs, pirfenidone and nintedanib, are approved by the European Medicines Agency and the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF). In this analysis, treatment patterns of European patients with IPF were investigated to understand antifibrotic prescribing and identify unmet needs in IPF treatment practice. METHODS: Between February and March 2016, respiratory physicians from France, Germany, Italy, Spain, and the UK participated in an online questionnaire designed to collect information on IPF treatment patterns in patients under their care...
September 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28915069/facilitators-and-barriers-to-positive-airway-pressure-adherence-for-adolescents-a-qualitative-study
#4
Zahra Alebraheem, Alene Toulany, Adele Baker, Jennifer Christian, Indra Narang
RATIONALE: Low adherence to positive airway pressure (PAP) treatment for adolescents with obstructive sleep apnea (OSA) can have long-term cardio-metabolic and developmental impact. OBJECTIVES: To explore the facilitators and barriers to PAP use in adolescents with OSA. METHODS: We conducted a qualitative study using a descriptive thematic analysis approach. A total of 21 interviews were conducted in the clinical setting with adolescents prescribed PAP to treat OSA within the previous 12 months...
September 15, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28912105/high-bmi-and-male-sex-as-risk-factor-for-increased-short-term-renal-impairment-in-living-kidney-donors-retrospective-analysis-of-289-consecutive-cases
#5
Lukas W Unger, Joy Feka, Philipp Sabler, Susanne Rasoul-Rockenschaub, Georg Györi, Michael Hofmann, Christoph Schwarz, Thomas Soliman, Georg Böhmig, Alexander Kainz, Andreas Salat, Gabriela A Berlakovich
BACKGROUND: Kidney transplantation represents the treatment of choice for end-stage renal disease (ESRD). However, nephrectomy bears certain short-as well as long-term risks for the healthy, voluntary donor. As obesity is increasing and is a known risk factor for surgical complications, we wanted to assess the impact of BMI on perioperative complication rates and renal function. MATERIALS AND METHODS: We retrospectively assessed patients undergoing living donor kidney nephrectomy at our institution...
September 11, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28906352/clinical-and-angiographic-outcomes-following-endovascular-treatment-of-very-small-3%C3%A2-mm-or-smaller-intracranial-aneurysm-a-single-center-experience
#6
Yongsheng Liu, Feng Wang, Xiaochen Fu, Yongjian Liu, Guodong Zhang, Ke Xu
Treatments for very small (3 mm or smaller) intracranial aneurysms (VSAs) remain controversial. The aim of this study was to evaluate the efficacy of endovascular treatment for VSAs and to evaluate clinical risk factors associated with complications.This retrospective study enrolled 82 VSA patients who underwent coil embolization in our institution. Angiographic outcomes were assessed according to the Meyers classification. The clinical results were evaluated using the modified Rankin scale (mRS) immediately after coiling, at discharge, and during follow-up...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905126/neuroanatomical-correlates-of-haptic-object-processing-combined-evidence-from-tractography-and-functional-neuroimaging
#7
Haemy Lee Masson, Hyeok-Mook Kang, Laurent Petit, Christian Wallraven
Touch delivers a wealth of information already from birth, helping infants to acquire knowledge about a variety of important object properties using their hands. Despite the fact that we are touch experts as much as we are visual experts, surprisingly, little is known how our perceptual ability in touch is linked to either functional or structural aspects of the brain. The present study, therefore, investigates and identifies neuroanatomical correlates of haptic perceptual performance using a novel, multi-modal approach...
September 13, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28904611/oxidative-dehydrogenation-of-c-c-and-c-n-bonds-a-convenient-approach-to-access-diverse-dihydro-heteroaromatic-compounds
#8
REVIEW
Santanu Hati, Ulrike Holzgrabe, Subhabrata Sen
Nitrogen heteroarenes form an important class of compounds which can be found in natural products, synthetic drugs, building blocks etc. Among the diverse strategies that were developed for the synthesis of nitrogen heterocycles, oxidative dehydrogenation is extremely effective. This review discusses various oxidative dehydrogenation strategies of C-C and C-N bonds to generate nitrogen heteroarenes from their corresponding heterocyclic substrates. The strategies are categorized under stoichiometric and catalytic usage of reagents that facilitate such transformations...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28904534/three-dimensional-organoid-system-transplantation-technologies-in-future-treatment-of-central-nervous-system-diseases
#9
REVIEW
NaiLi Wei, ZiFang Quan, Hailiang Tang, JianHong Zhu
In recent years, scientists have made great achievements in understanding the development of human brain and elucidating critical elements of stepwise spatiotemporal control strategies in neural stem cell specification lineage, which facilitates successful induction of neural organoid in vitro including the cerebral cortex, cerebellar, neural tube, hippocampus cortex, pituitary, and optic cup. Besides, emerging researches on neural organogenesis promote the application of 3D organoid system transplantation in treating central nervous system (CNS) diseases...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28903869/interventions-to-reduce-non-typhoidal-salmonella-in-pigs-during-transport-to-slaughter-and-lairage-systematic-review-meta-analysis-and-research-synthesis-based-infection-models-in-support-of-assessment-of-effectiveness
#10
REVIEW
Barbara J Wilhelm, Ian Young, Sarah Cahill, Patricia Desmarchelier, Rei Nakagawa, Andrijana Rajić
A systematic review of the effectiveness of interventions to reduce Salmonella prevalence or concentration in pork was undertaken. A broad search was conducted in two electronic databases. Each citation was appraised using screening tools designed and tested a priori. Level 1 relevance screening excluded irrelevant citations; level 2 confirmed relevance and categorized. Data were then extracted, and intervention categories were descriptively summarized. Meta-analysis was performed to provide a summary estimate of treatment effect where two or more studies investigated the same intervention in comparable populations...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28903700/motivational-differences-in-seeking-out-evaluative-categorization-information
#11
Rachel Smallman, Brittney Becker
Previous research shows that people draw finer evaluative distinctions when rating liked versus disliked objects (e.g., wanting a 5-point scale to evaluate liked cuisines and a 3-point scale to rate disliked cuisines). Known as the preference-categorization effect, this pattern may exist not only in how individuals form evaluative distinctions but also in how individuals seek out evaluative information. The current research presents three experiments that examine motivational differences in evaluative information seeking (rating scales and attributes)...
July 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28902066/latent-class-analysis-of-adhd-neurodevelopmental-and-mental-health-comorbidities
#12
Benjamin Zablotsky, Matthew D Bramlett, Susanna N Visser, Melissa L Danielson, Stephen J Blumberg
OBJECTIVE: Many children diagnosed with attention-deficit/hyperactivity disorder (ADHD) experience co-occurring neurodevelopmental and psychiatric disorders, and those who do often exhibit higher levels of impairment than children with ADHD alone. This study provides a latent class analysis (LCA) approach to categorizing children with ADHD into comorbidity groups, evaluating condition expression and treatment patterns in each group. METHODS: Parent-reported data from a large probability-based national sample of children diagnosed with ADHD (2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome) were used for an LCA to identify groups of children with similar groupings of neurodevelopmental and psychiatric comorbidities among children with current ADHD (n = 2495)...
September 8, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28901043/survey-design-for-precise-fire-management-conservation-targets
#13
Holly Sitters, Julian Di Stefano, Timothy Wills, Matthew Swan, Alan York
Common goals of ecological fire management are to sustain biodiversity and minimize extinction risk. A novel approach to achieving these goals determines the relative proportions of vegetation growth stages (equivalent to successional stages, which are categorical representations of time since fire) that maximize a biodiversity index. The method combines data describing species abundances in each growth stage with numerical optimization to define an optimal growth-stage structure which provides a conservation-based operational target for managers...
September 12, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28898244/neuroplace-categorizing-urban-places-according-to-mental-states
#14
Lulwah Al-Barrak, Eiman Kanjo, Eman M G Younis
Urban spaces have a great impact on how people's emotion and behaviour. There are number of factors that impact our brain responses to a space. This paper presents a novel urban place recommendation approach, that is based on modelling in-situ EEG data. The research investigations leverages on newly affordable Electroencephalogram (EEG) headsets, which has the capability to sense mental states such as meditation and attention levels. These emerging devices have been utilized in understanding how human brains are affected by the surrounding built environments and natural spaces...
2017: PloS One
https://www.readbyqxmd.com/read/28893815/risk-stratification-methods-and-provision-of-care-management-services-in-comprehensive-primary-care-initiative-practices
#15
Ashok Reddy, Laura Sessums, Reshma Gupta, Janel Jin, Tim Day, Bruce Finke, Asaf Bitton
PURPOSE: Risk-stratified care management is essential to improving population health in primary care settings, but evidence is limited on the type of risk stratification method and its association with care management services. METHODS: We describe risk stratification patterns and association with care management services for primary care practices in the Comprehensive Primary Care (CPC) initiative. We undertook a qualitative approach to categorize risk stratification methods being used by CPC practices and tested whether these stratification methods were associated with delivery of care management services...
September 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28893235/inadequate-birth-spacing-is-perceived-as-riskier-than-all-family-planning-methods-except-sterilization-and-abortion-in-a-qualitative-study-among-urban-nigerians
#16
Hilary M Schwandt, Joanna Skinner, Luciana Estelle Hebert, Lisa Cobb, Abdulmumin Saad, Mojisola Odeku
BACKGROUND: Fertility is high in Nigeria and contraceptive use is low. Little is known about how urban Nigerians perceive the risk of contraceptive use in relation to pregnancy and birth. This study examines and compares the risk perception of family planning methods and pregnancy related scenarios among urban Nigerians. METHODS: A total of 26 focus group discussions with 243 participants were conducted in September and October 2010 in Ibadan and Kaduna. The groups were stratified by sex, age, family planning use, and city...
September 11, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28891977/polytrauma-defined-by-the-new-berlin-definition-a-validation-test-based-on-propensity-score-matching-approach
#17
Cheng-Shyuan Rau, Shao-Chun Wu, Pao-Jen Kuo, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Ching-Hua Hsieh
Background: Polytrauma patients are expected to have a higher risk of mortality than that obtained by the summation of expected mortality owing to their individual injuries. This study was designed to investigate the outcome of patients with polytrauma, which was defined using the new Berlin definition, as cases with an Abbreviated Injury Scale (AIS) ≥ 3 for two or more different body regions and one or more additional variables from five physiologic parameters (hypotension [systolic blood pressure ≤ 90 mmHg], unconsciousness [Glasgow Coma Scale score ≤ 8], acidosis [base excess ≤ -6...
September 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28891974/recent-advances-in-experimental-whole-genome-haplotyping-methods
#18
REVIEW
Mengting Huang, Jing Tu, Zuhong Lu
Haplotype plays a vital role in diverse fields; however, the sequencing technologies cannot resolve haplotype directly. Pioneers demonstrated several approaches to resolve haplotype in the early years, which was extensively reviewed. Since then, numerous methods have been developed recently that have significantly improved phasing performance. Here, we review experimental methods that have emerged mainly over the past five years, and categorize them into five classes according to their maximum scale of contiguity: (i) encapsulation, (ii) 3D structure capture and construction, (iii) compartmentalization, (iv) fluorography, (v) long-read sequencing...
September 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28890153/medicinal-plants-for-in-vitro-antiplasmodial-activities-a-systematic-review-of-literature
#19
REVIEW
Martha Tibebu Lemma, Ali Mahmoud Ahmed, Mohamed Tamer Elhady, Huyen Thi Ngo, Tran Le-Huy Vu, To Kim Sang, Eduardo Campos-Alberto, Abdelrahman Sayed, Shusaku Mizukami, Kesara Na-Bangchang, Nguyen Tien Huy, Kenji Hirayama, Juntra Karbwang
The increasing resistance of malaria to drugs raise the need to new antimalarial agents. Antiplasmodial herbs and their active compounds are the most promising source the new antimalarial agents. This study aimed to identify the medicinal plants with very good in vitro antiplasmodial activities, with half-maximal inhibitory concentration (IC50)≤1μg/ml, and to determine trends in the process of screening their antiplasmodial activities. A total of 58 reports published in the English language were retrieved from the bibliographical databases...
September 7, 2017: Parasitology International
https://www.readbyqxmd.com/read/28889755/the-dangers-of-conflating-gambling-related-harm-with-disordered-gambling
#20
Matthew Browne, Matthew J Rockloff
In their critical review of the prevention paradox (PP) applied to gambling-related harm, Delfabbro and King (2017) raise a number of concerns regarding specific assumptions, methods, and findings as well as the general conceptual approach. Besides discussing the PP, the review also considers the merits of considering a "continuum of harm," as opposed to the more traditional categorical approach to classifying problem gamblers. Their critique is carefully modulated and balanced, and starts a useful dialogue in the context of a public health approach to gambling...
September 11, 2017: Journal of Behavioral Addictions
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