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https://www.readbyqxmd.com/read/28820722/house-structure-is-associated-with-plasmodium-falciparum-infection-in-a-low-transmission-setting-in-southern-zambia
#1
Matthew M Ippolito, Kelly M Searle, Harry Hamapumbu, Timothy M Shields, Jennifer C Stevenson, Philip E Thuma, William J Moss, For The Southern Africa International Center Of Excellence For Malaria Research
House structure may influence the risk of malaria by affecting mosquito entry and indoor resting. Identification of construction features associated with protective benefits could inform vector control approaches, even in low-transmission settings. We examined the association between house structure and malaria prevalence in a cross-sectional analysis of 2,788 children and adults residing in 866 houses in a low-transmission area of Southern Province, Zambia, over the period 2008-2012. Houses were categorized according to wall (brick/cement block or mud/grass) and roof (metal or grass) material...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28818613/network-analysis-a-new-way-of-understanding-psychopathology
#2
Eduardo Fonseca-Pedrero
Current taxonomic systems are based on a descriptive and categorical approach where psychopathological symptoms and signs are caused by a hypothetical underlying mental disorder. In order to circumvent the limitations of classification systems, it is necessary to incorporate new conceptual and psychometric models that allow to understand, analyze and intervene in psychopathological phenomena from another perspective. The main goal was to present a new approach called network analysis for its application in the field of psychopathology...
August 14, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28817344/a-guide-to-approaching-regulatory-considerations-for-lentiviral-mediated-gene-therapies
#3
Michael White, Roger Whittaker, Carolina Gándara, Elizabeth A Stoll
Lentiviral vectors are increasingly the gene transfer tool of choice for gene or cell therapies, with multiple clinical investigations showing promise for this viral vector in terms of both safety and efficacy. The third-generation vector system is well characterized, effectively delivers genetic material and maintains long-term stable expression in target cells, delivers larger amounts of genetic material than other methods, is nonpathogenic, and does not cause an inflammatory response in the recipient. This report aims to help academic scientists and regulatory managers negotiate the governance framework to achieve successful translation of a lentiviral vector-based gene therapy...
August 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28816498/the-relationship-between-gaming-disorder-and-addiction-requires-a-behavioral-analysis
#4
Richard J E James, Richard J Tunney
In their position paper, Aarseth et al. (2016) bring to light several timely issues concerning the categorization of gaming disorder as a form of addiction and as a discrete mental disorder. In our commentary, we welcome their caution toward this move and their discussion of the equivocal scientific data in its support and the potential negative consequences for gamers. We suggest that a more heterogeneous approach is required for understanding any behavioral addiction, as concepts from gambling appear to be more relevant for aspects of mobile gaming than for video games more generally...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28815681/meta-analytical-synthesis-of-regression-coefficients-under-different-categorization-scheme-of-continuous-covariates
#5
Daisuke Yoneoka, Masayuki Henmi
Recently, the number of clinical prediction models sharing the same regression task has increased in the medical literature. However, evidence synthesis methodologies that use the results of these regression models have not been sufficiently studied, particularly in meta-analysis settings where only regression coefficients are available. One of the difficulties lies in the differences between the categorization schemes of continuous covariates across different studies. In general, categorization methods using cutoff values are study specific across available models, even if they focus on the same covariates of interest...
August 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28815144/a-clinical-decision-support-system-for-monitoring-post-colonoscopy-patient-follow-up-and-scheduling
#6
Roxanne Wadia, Mark Shifman, Forrest L Levin, Luis Marenco, Cynthia A Brandt, Kei-Hoi Cheung, Tamar Taddei, Michael Krauthammer
This paper describes a natural language processing (NLP)-based clinical decision support (CDS) system that is geared towards colon cancer care coordinators as the end users. The system is implemented using a metadata- driven Structured Query Language (SQL) function (discriminant function). For our pilot study, we have developed a training corpus consisting of 2,085 pathology reports from the VA Connecticut Health Care System (VACHS). We categorized reports as "actionable"- requiring close follow up, or "non-actionable"- requiring standard or no follow up...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814541/assessing-the-fragile-x-syndrome-newborn-screening-landscape
#7
Catharine Riley, Anne Wheeler
BACKGROUND: Fragile X syndrome (FXS) is the most common known inherited form of intellectual disability. Early identification is an important step in linking FXS individuals with appropriate and timely medical and social services. Newborn screening (NBS) is 1 approach that has been used for other conditions to facilitate early identification. METHODS: A literature review was conducted to identify issues, barriers, challenges, and approaches to addressing challenges related to NBS for FXS...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28814261/recent-studies-on-the-care-of-first-febrile-urinary-tract-infection-in-infants-and-children-for-the-pediatric-hospitalist
#8
Ashley G Sutton, Nicole Chandler, Kenneth B Roberts
BACKGROUND: Urinary tract infection (UTI) is a common cause of bacterial infection in young children, and accounts for a significant number of pediatric hospitalizations. OBJECTIVE: To review recent publications focusing on the care of children hospitalized with their first febrile UTI Methods: A PubMed search was performed including publications from 2011-2016 on first febrile UTI in childhood. Abstracts were reviewed for being relevant to the care of hospitalized children and their follow-up...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28813340/athletes-with-eating-disorder-symptomatology-a-specific-population-with-specific-needs
#9
REVIEW
A P Karin de Bruin
This review presents recent studies into the prevalence, process, treatment and prevention of eating disorders in athletes. Most prevalence studies showed that increased risk for athletes exists. Methodological challenges for future prevalence studies concern the choice of methods, measurements, categorization, and sampling. To determine why athletes are at increased risk, more prospective studies using multi-factorial models and multiple risk pathways are needed. Epidemiological risk factor studies, however, do not provide us with a true understanding of the eating disorder process...
August 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28812274/oxytocin-and-anxiety-disorders
#10
Michael G Gottschalk, Katharina Domschke
In the present chapter, we review the literature focusing on oxytocin (OT)-centered research in anxiety spectrum conditions, comprising separation anxiety disorder, specific phobias, social anxiety disorder (SAD), panic disorder, generalized anxiety disorder, and anxiety-related endophenotypes (e.g., trust behavior, behavioral inhibition, neuroticism, and state/trait anxiety). OT receptor gene (OXTR) polymorphisms have been implicated in gene-environment interactions with attachment style and childhood maltreatment and to influence clinical outcomes, including SAD intensity and limbic responsiveness...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812019/whole-body-spect-ct-versus-planar-bone-scan-with-targeted-spect-ct-for-metastatic-workup
#11
Olivier Rager, René Nkoulou, Nadia Exquis, Valentina Garibotto, Claire Tabouret-Viaud, Habib Zaidi, Gaël Amzalag, Stephanie Anne Lee-Felker, Thomas Zilli, Osman Ratib
PURPOSE: The use of SPECT/CT in bone scans has been widespread in recent years, but there are no specific guidelines concerning the optimal acquisition protocol. Two strategies have been proposed: targeted SPECT/CT for equivocal lesions detected on planar images or systematic whole-body SPECT/CT. Our aim was to compare the diagnostic accuracy of the two approaches. METHODS: 212 consecutive patients with a history of cancer were referred for bone scans to detect bone metastases...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28812013/intelligent-techniques-using-molecular-data-analysis-in-leukaemia-an-opportunity-for-personalized-medicine-support-system
#12
REVIEW
Haneen Banjar, David Adelson, Fred Brown, Naeem Chaudhri
The use of intelligent techniques in medicine has brought a ray of hope in terms of treating leukaemia patients. Personalized treatment uses patient's genetic profile to select a mode of treatment. This process makes use of molecular technology and machine learning, to determine the most suitable approach to treating a leukaemia patient. Until now, no reviews have been published from a computational perspective concerning the development of personalized medicine intelligent techniques for leukaemia patients using molecular data analysis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811884/factors-contributing-to-the-accumulation-of-reproductive-isolation-a-mixed-model-approach
#13
Dean M Castillo
The analysis of large datasets describing reproductive isolation between species has been extremely influential in the study of speciation. However, the statistical methods currently used for these data limit the ability to make direct inferences about the factors predicting the evolution of reproductive isolation. As a result, our understanding of iconic patterns and rules of speciation rely on indirect analyses that have clear statistical limitations. Phylogenetic mixed models are commonly used in ecology and evolution, but have not been applied to studies of reproductive isolation...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811032/recent-advancements-and-future-trends-in-environmental-analysis-sample-preparation-liquid-chromatography-and-mass-spectrometry
#14
REVIEW
Virginia Pérez-Fernández, Lucia Mainero Rocca, Pierpaolo Tomai, Salvatore Fanali, Alessandra Gentili
Among the thousands of chemicals having potential to enter the environment, the NORMAN network has identified at least 700 substances categorized into 20 classes in the European surface waters. Pesticides, pharmaceuticals, disinfection by-products, wood preservation and industrial chemicals are the prominent classes. Since the impact of these substances on aquatic life and human health might be dramatic, action is urgently required at multiple levels; one of them is just related to the development of more and more sensible and selective analytical methods...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28809656/animal-assisted-therapies-and-dementia-a-systematic-mapping-review-using-the-lived-environment-life-quality-lelq-model
#15
Wendy Wood, Beth Fields, Michelle Rose, Merinda McLure
OBJECTIVE: The authors mapped the literature on animal-assisted therapies (AATs) and institutionalized adults with dementia onto the Lived Environment Life Quality (LELQ) Model as a guide for future services and research. METHOD: Refereed literature addressing AATs and institutionalized people with dementia was comprehensively gathered, described, categorized, and synthesized in this systematic mapping review. RESULTS: From 1,342 screened records, the authors included 10 research articles that incorporated dogs in therapy for institutionalized adults with dementia...
September 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28806410/the-influence-of-speed-abilities-and-technical-skills-in-early-adolescence-on-adult-success-in-soccer-a-long-term-prospective-analysis-using-anova-and-sem-approaches
#16
Oliver Höner, Daniel Leyhr, Augustin Kelava
Several talent development programs in youth soccer have implemented motor diagnostics measuring performance factors. However, the predictive value of such tests for adult success is a controversial topic in talent research. This prospective cohort study evaluated the long-term predictive value of 1) motor tests and 2) players' speed abilities (SA) and technical skills (TS) in early adolescence. The sample consisted of 14,178 U12 players from the German talent development program. Five tests (sprint, agility, dribbling, ball control, shooting) were conducted and players' height, weight as well as relative age were assessed at nationwide diagnostics between 2004 and 2006...
2017: PloS One
https://www.readbyqxmd.com/read/28805173/latent-traits-of-impulsivity-and-compulsivity-toward-dimensional-psychiatry
#17
S R Chamberlain, J Stochl, S A Redden, J E Grant
BACKGROUND: The concepts of impulsivity and compulsivity are commonly used in psychiatry. Little is known about whether different manifest measures of impulsivity and compulsivity (behavior, personality, and cognition) map onto underlying latent traits; and if so, their inter-relationship. METHODS: A total of 576 adults were recruited using media advertisements. Psychopathological, personality, and cognitive measures of impulsivity and compulsivity were completed...
August 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28804985/a-randomised-controlled-comparison-of-second-level-treatment-approaches-for-treatment-resistant-adults-with-bulimia-nervosa-and-binge-eating-disorder-assessing-the-benefits-of-virtual-reality-cue-exposure-therapy
#18
Marta Ferrer-García, José Gutiérrez-Maldonado, Joana Pla-Sanjuanelo, Ferran Vilalta-Abella, Giuseppe Riva, Massimo Clerici, Joan Ribas-Sabaté, Alexis Andreu-Gracia, Fernando Fernandez-Aranda, Laura Forcano, Nadine Riesco, Isabel Sánchez, Neli Escandón-Nagel, Osane Gomez-Tricio, Virginia Tena, Antonios Dakanalis
A question that arises from the literature on therapy is whether second-level treatment is effective for patients with recurrent binge eating who fail first-level treatment. It has been shown that subjects who do not stop binge eating after an initial structured cognitive-behavioural treatment (CBT) programme benefit from additional CBT (A-CBT) sessions; however, it has been suggested that these resistant patients would benefit even more from cue exposure therapy (CET) targeting features associated with poor response (e...
August 14, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28802582/label-free-quantitative-proteomic-analysis-of-lactobacillus-fermentum-ncdc-400-during-bile-salt-exposure
#19
Gurjeet Kaur, Syed Azmal Ali, Sudarshan Kumar, Ashok Kumar Mohanty, Pradip Behare
Lactobacillus fermentum NCDC 400 is a commonly used and a comprehensively studied probiotic organism. The distinctive capability to endure the harsh environment of the gastrointestinal tract owing to the presence of bile salts in gastric juice facilitates gut microbiota, especially the probiotic organisms to transiently inhabit the host gut. In the present study, Label-Free Quantification (LFQ) approach has been employed to analyze the expression pattern of Lactobacillus fermentum NCDC 400 strain proteins, under bile acid stress, using high-resolution mass spectrometer connected to nano-liquid chromatography (LC) system...
August 9, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28802054/a-dyadic-typology-of-social-desires-in-couples
#20
Thomas Czikmantori, Birk Hagemeyer, Stefan Engeser
OBJECTIVE: Employing a couple-centered approach to social motivation in intimate relationships, we developed a dyadic typology based on the ABC model of communal and agentic social desires. METHOD: Using latent profile analysis, 631 heterosexual couples (age women: M = 39.7, SD = 13.6; age men: M = 42.0, SD = 14.1) were categorized regarding both partners' self-reported desires for closeness with partner, for affiliation with friends, and for being alone. Couple types were described using self-reported indicators of relationship functioning...
August 12, 2017: Journal of Personality
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