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https://www.readbyqxmd.com/read/28720129/predictors-of-return-to-work-among-patients-in-treatment-for-common-mental-disorders-a-pre-post-study
#1
Mattias Victor, Bjørn Lau, Torleif Ruud
BACKGROUND: Effects of return to work (RTW) interventions vary, and more knowledge is needed about the factors that contribute to RTW. This study investigated changes in work participation and mental health, and predictors of RTW among patients being treated for common mental disorders (CMDs). METHODS: The study was a prospective pre-post study of 164 patients treated at an RTW outpatient clinic for CMDs. Differences between before and after treatment were analysed using paired t tests for continuous variables and marginal homogeneity test for categorical variables...
July 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28715999/factors-affecting-interactome-based-prediction-of-human-genes-associated-with-clinical-signs
#2
Sara González-Pérez, Florencio Pazos, Mónica Chagoyen
BACKGROUND: Clinical signs are a fundamental aspect of human pathologies. While disease diagnosis is problematic or impossible in many cases, signs are easier to perceive and categorize. Clinical signs are increasingly used, together with molecular networks, to prioritize detected variants in clinical genomics pipelines, even if the patient is still undiagnosed. Here we analyze the ability of these network-based methods to predict genes that underlie clinical signs from the human interactome...
July 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28715445/cytological-diagnostic-features-of-late-breast-implant-seromas-from-reactive-to-anaplastic-large-cell-lymphoma
#3
Arianna Di Napoli, Giuseppina Pepe, Enrico Giarnieri, Claudia Cippitelli, Adriana Bonifacino, Mauro Mattei, Maurizio Martelli, Carlo Falasca, Maria Christina Cox, Iolanda Santino, Maria Rosaria Giovagnoli
Late breast implant seroma may be the presentation of a breast implant-associated anaplastic large cell lymphoma (BI-ALCL), which claims for a prompt recognition. However, BI-ALCL diagnosis on fine-needle aspiration (FNA) might be challenging for pathologists lacking experience with peri-implant breast effusions. Sixty-seven late breast implant seromas collected by FNA from 50 patients were evaluated by Papanicolaou smear stain and immunocytochemistry on cell blocks. A diagnostic algorithm based on the cellular composition, cell morphology and percentage of CD30+ cells was developed...
2017: PloS One
https://www.readbyqxmd.com/read/28713866/implications-of-the-hierarchical-structure-of-psychopathology-for-psychiatric-neuroimaging
#4
David H Zald, Benjamin B Lahey
Research into the neurobiological substrates of psychopathology has been impeded by heterogeneity within diagnostic categories, comorbidity among mental disorders, and the presence of symptoms that transcend diagnostic categories. Solutions to these issues increasingly focus neurobiological research on isolated or narrow groupings of symptoms or functional constructs rather than categorical diagnoses. Here we argue for a more integrative approach that also incorporates the broad hierarchical structure of psychopathological symptoms and their etiological mechanisms...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28711662/the-clinical-and-prognostic-value-of-motor-abnormalities-in-psychosis-and-the-importance-of-instrumental-assessment
#5
REVIEW
Peter N van Harten, Sebastian Walther, Jerillyn S Kent, Scott R Sponheim, Vijay A Mittal
Motor abnormalities comprise several clinical signs intrinsic to psychosis. Critically, these features are of prognostic value in individuals at-risk for psychosis, and for those in early stages of psychotic disorders. Motor abnormalities such as tremor, rigidity, and neurological soft signs often go unrecognized. Currently, advances in this area are limited by a paucity of theoretical conceptions categorizing or linking these behaviors to underlying neurobiology affected in psychosis. However, emerging technological advances have significantly improved the ability to detect and assess motor abnormalities with objective instruments in a timely and reliable manner...
July 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28711146/drug-repositioning-strategies-for-the-identification-of-novel-therapies-for-rheumatic-autoimmune-inflammatory-diseases
#6
REVIEW
Amrie C Grammer, Peter E Lipsky
Rheumatic Autoimmune Inflammatory Diseases such as Sjögren's and lupus lack modern treatments. Less than 5% of drugs approved by the FDA from 2014 to mid-2016 had a RAID indication. Many RAID standard-of-care drugs were repurposed based on serendipitous observations, similarity-of-disease categorization, and/or off-target effects. Recently, drug repurposing has become more intentional, relying on an evolving awareness of molecular underpinnings, as well as a better understanding of drug-target interactions by computational modeling...
August 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28709430/exploring-the-factor-structure-of-the-health-of-the-nation-outcomes-scale-honos-in-a-sample-of-patients-with-schizophrenia-schizotypal-and-delusional-disorders
#7
Wayne Smith, Silia Vitoratou, Paul McCrone, Anita Patel
BACKGROUND: The Health of the Nation Outcomes Scale (HoNOS) is recommended for use by the English National Service Framework for Mental Health and by the working group on outcome indicators for severe mental illnesses to the Department of Health. It was developed to measure the health and social functioning of people with severe mental illness. Since the development of the HoNOS many have debated its latent structure. This paper examines the latent structure of the HoNOS using current factor analysis techniques...
July 14, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28708857/comparative-transcriptome-analysis-of-flower-heterosis-in-two-soybean-f1-hybrids-by-rna-seq
#8
Chunbao Zhang, Chunjing Lin, Fuyou Fu, Xiaofang Zhong, Bao Peng, Hao Yan, Jingyong Zhang, Weilong Zhang, Pengnian Wang, Xiaoyang Ding, Wei Zhang, Limei Zhao
Heterosis has been widely exploited as an approach to enhance crop traits during breeding. However, its underlying molecular genetic mechanisms remain unclear. Recent advances in RNA sequencing technology (RNA-seq) have provided an opportunity to conduct transcriptome profiling for heterosis studies. We used RNA-seq to analyze the flower transcriptomes of two F1 hybrid soybeans (HYBSOY-1 and HYBSOY-5) and their parents. More than 385 million high-quality reads were generated and aligned against the soybean reference genome...
2017: PloS One
https://www.readbyqxmd.com/read/28708754/the-effect-of-vasodilatory-medications-on-radial-artery-spasm-in-patients-undergoing-transradial-coronary-artery-procedures-a-systematic-review
#9
Elizabeth Curtis, Ritin Fernandez, Astin Lee
BACKGROUND: The uptake of percutaneous coronary procedures via the radial artery has increased internationally due to the decreased risk of complications and increased patient satisfaction. The increased susceptibility of the radial artery to spasm however presents a potential risk for procedural failure. Although most experts agree on the need for prophylactic medications to reduce radial artery spasm, currently there is inconsistency in literature regarding the most effective vasodilatory medication or combination of medications...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28708131/a-clinicopathological-approach-to-the-diagnosis-of-dementia
#10
REVIEW
Fanny M Elahi, Bruce L Miller
The most definitive classification systems for dementia are based on the underlying pathology which, in turn, is categorized largely according to the observed accumulation of abnormal protein aggregates in neurons and glia. These aggregates perturb molecular processes, cellular functions and, ultimately, cell survival, with ensuing disruption of large-scale neural networks subserving cognitive, behavioural and sensorimotor functions. The functional domains affected and the evolution of deficits in these domains over time serve as footprints that the clinician can trace back with various levels of certainty to the underlying neuropathology...
July 14, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28707958/gadofosveset-enhanced-thoracic-mr-venography-a-comparative-study-evaluating-steady-state-imaging-versus-conventional-first-pass-time-resolved-dynamic-imaging
#11
Teik C See, Andrew J Patterson, Nicholas J Hilliard, Ed Soh, Andrew P Winterbottom, Ilse Patterson, Richard A Parker, Martin J Graves, David J Lomas
Background Dedicated blood-pool contrast agents combined with optimal angiographic protocols could improve the diagnostic accuracy of thoracic magnetic resonance angiography (MRA). Purpose To assess the clinical utility of Gadofesveset-enhanced imaging and compare an optimized steady-state (SS) sequence against conventional first-pass dynamic multi-phase (DMP) imaging. Material and Methods Twenty-nine patients (17 men, 12 women; mean age = 42.7, age range = 18-72 years) referred for MR thoracic venography were recruited...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28707404/sustained-versus-standard-inflations-during-neonatal-resuscitation-to-prevent-mortality-and-improve-respiratory-outcomes
#12
REVIEW
Matteo Bruschettini, Colm Pf O'Donnell, Peter G Davis, Colin J Morley, Lorenzo Moja, Simona Zappettini, Maria Grazia Calevo
BACKGROUND: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable effective breathing. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volume within the lungs. OBJECTIVES: To assess the efficacy of an initial sustained (> 1 second duration) lung inflation versus standard inflations (≤ 1 second) in newly born infants receiving resuscitation with intermittent PPV...
July 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28706922/barriers-and-enablers-to-proper-diabetic-foot-care-amongst-community-dwellers-in-an-asian-population-a-qualitative-study
#13
Andrew Arjun Sayampanathan, Amit Nirmal Cuttilan, Christopher J Pearce
BACKGROUND: Diabetic foot complications are common within Asian populations. They arise due to poor diabetic control and foot care. In this study, we aimed to identify the causes for proper and improper diabetic foot care. METHODS: A qualitative study consisting of key informant interviews with 17 healthcare professionals, including doctors and various allied health workers, was conducted. Participants included had at least five years of caring for diabetic foot patients either in public institutions or private clinics...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28704975/current-knowledge-on-the-use-of-computational-toxicology-in-hazard-assessment-of-metallic-engineered-nanomaterials
#14
REVIEW
Guangchao Chen, Willie Peijnenburg, Yinlong Xiao, Martina G Vijver
As listed by the European Chemicals Agency, the three elements in evaluating the hazards of engineered nanomaterials (ENMs) include the integration and evaluation of toxicity data, categorization and labeling of ENMs, and derivation of hazard threshold levels for human health and the environment. Assessing the hazards of ENMs solely based on laboratory tests is time-consuming, resource intensive, and constrained by ethical considerations. The adoption of computational toxicology into this task has recently become a priority...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28704390/inter-rater-reliability-of-categorical-versus-continuous-scoring-of-fish-vitality-does-it-affect-the-utility-of-the-reflex-action-mortality-predictor-ramp-approach
#15
Pieter Meeremans, Noëlle Yochum, Marc Kochzius, Bart Ampe, Frank A M Tuyttens, Sven Sebastian Uhlmann
Scoring reflex responsiveness and injury of aquatic organisms has gained popularity as predictors of discard survival. Given this method relies upon the individual interpretation of scoring criteria, an evaluation of its robustness is done here to test whether protocol-instructed, multiple raters with diverse backgrounds (research scientist, technician, and student) are able to produce similar or the same reflex and injury score for one of the same flatfish (European plaice, Pleuronectes platessa) after experiencing commercial fishing stressors...
2017: PloS One
https://www.readbyqxmd.com/read/28701104/a-document-analysis-of-drowning-prevention-education-resources-in-the-united-states
#16
Adam Bradley Katchmarchi, Andrea R Taliaferro, Hannah Joy Kipfer
There have been long-standing calls to better educate the public at large on risks of drowning; yet limited evaluation has taken place on current resources in circulation. The purpose of this qualitative research is to develop an understanding of the content in currently circulated drowning prevention resources in the United States. Data points (n = 451) consisting of specific content within 25 different drowning prevention educational resources were analyzed using document analysis methods; a grounded theory approach was employed to allow for categorical development and indexing of the data...
July 13, 2017: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/28700609/organic-farming-enhances-soil-microbial-abundance-and-activity-a-meta-analysis-and-meta-regression
#17
Martina Lori, Sarah Symnaczik, Paul Mäder, Gerlinde De Deyn, Andreas Gattinger
Population growth and climate change challenge our food and farming systems and provide arguments for an increased intensification of agriculture. A promising option is eco-functional intensification through organic farming, an approach based on using and enhancing internal natural resources and processes to secure and improve agricultural productivity, while minimizing negative environmental impacts. In this concept an active soil microbiota plays an important role for various soil based ecosystem services such as nutrient cycling, erosion control and pest and disease regulation...
2017: PloS One
https://www.readbyqxmd.com/read/28699998/culture-bound-syndromes-in-migratory-contexts-the-case-of-bolivian-immigrants
#18
María Teresa Roldán-Chicano, José Fernández-Rufete, César Hueso-Montoro, María Del Mar García-López, Javier Rodríguez-Tello, María Dolores Flores-Bienert
Objective: to describe the culture-bound syndromes maintained by Bolivian immigrants in the new migratory context and analyze the care processes of these health problems. Method: qualitative research with an ethnographic methodological approach. Sample: 27 Bolivian immigrants. In-depth interviews and participatory observation were the strategies used for data collection. Data were classified and categorized into logical schemes manually and using the ATLAS-ti program v...
July 10, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28699937/techniques-and-behaviors-associated-with-exemplary-inpatient-general-medicine-teaching-an-exploratory-qualitative-study
#19
Nathan Houchens, Molly Harrod, Stephanie Moody, Karen Fowler, Sanjay Saint
BACKGROUND: Clinician educators face numerous obstacles to their joint mission of facilitating high-quality learning while also delivering patient-centered care. Such challenges necessitate increased attention to the work of exemplary clinician educators, their respective teaching approaches, and the experiences of their learners. OBJECTIVE: To describe techniques and behaviors utilized by clinician educators to facilitate excellent teaching during inpatient general medicine rounds...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28698644/cognitive-performance-in-healthy-older-adults-relates-to-spontaneous-switching-between-states-of-functional-connectivity-during-rest
#20
Joana Cabral, Diego Vidaurre, Paulo Marques, Ricardo Magalhães, Pedro Silva Moreira, José Miguel Soares, Gustavo Deco, Nuno Sousa, Morten L Kringelbach
Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment...
July 11, 2017: Scientific Reports
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