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Bipolar differential diagnosis

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https://www.readbyqxmd.com/read/28593691/psychopharmacological-treatment-of-psychotic-mania-and-psychotic-bipolar-depression-compared-to-non-psychotic-mania-and-non-psychotic-bipolar-depression
#1
Louise B Bjørklund, Henriette T Horsdal, Ole Mors, Christiane Gasse, Søren D Østergaard
OBJECTIVES: An evidence base for the treatment of mania and bipolar depression with psychotic symptoms is lacking. Nevertheless, clinicians may have a preference for treating episodes of bipolar disorder with or without psychotic symptoms in different ways, which is likely to reflect notions of differential efficacy of treatments between these subtypes. This study aimed to investigate whether the psychopharmacological treatment of psychotic and non-psychotic episodes of mania and bipolar depression, respectively, differs in clinical practice...
June 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28560261/brain-structure-function-and-neurochemistry-in-schizophrenia-and-bipolar-disorder-a-systematic-review-of-the-magnetic-resonance-neuroimaging-literature
#2
Badari Birur, Nina Vanessa Kraguljac, Richard C Shelton, Adrienne Carol Lahti
Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder. A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and genetic studies were deemed eligible for systematic review...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28546141/clinical-insight-into-latent-variables-of-psychiatric-questionnaires-for-mood-symptom-self-assessment
#3
Athanasios Tsanas, Kate Saunders, Amy Bilderbeck, Niclas Palmius, Guy Goodwin, Maarten De Vos
BACKGROUND: We recently described a new questionnaire to monitor mood called mood zoom (MZ). MZ comprises 6 items assessing mood symptoms on a 7-point Likert scale; we had previously used standard principal component analysis (PCA) to tentatively understand its properties, but the presence of multiple nonzero loadings obstructed the interpretation of its latent variables. OBJECTIVE: The aim of this study was to rigorously investigate the internal properties and latent variables of MZ using an algorithmic approach which may lead to more interpretable results than PCA...
May 25, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28536741/does-diagnosis-make-a-difference-estimating-the-impact-of-an-hiv-medication-adherence-intervention-for-persons-with-serious-mental-illness
#4
Natasha Dalseth, Regina Szucs Reed, Michael Hennessy, Marlene M Eisenberg, Michael B Blank
The heightened risk of persons with serious mental illness to contract and transmit human immunodeficiency virus (HIV) is a public health problem. Here we evaluate the interaction between psychiatric diagnosis and response to a community based-intervention targeted at treatment adherence in 236 HIV+ persons with co-occurring mental illness. To examine differential effectiveness of the intervention for categories of patient diagnosis, we reanalyzed the data after stratifying participants into two diagnostic groups: (1) participants with depressive disorders without psychosis and (2) participants with a psychotic or bipolar disorder...
May 23, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28535448/bipolar-postpartum-depression-an-update-and-recommendations
#5
REVIEW
Verinder Sharma, Minakshi Doobay, Christine Baczynski
BACKGROUND: Over the past few years there has been a surge of interest in the study of bipolar postpartum depression (PPD); however, questions remain about its prevalence, screening, clinical features, and treatment. METHODS: Three electronic databases, MEDLINE/PubMed (1966-2016), PsycINFO (1806-2016), and the Cochrane Database of Systematic Reviews, were searched using a combination of the keywords bipolar, depression, postpartum, peripartum, prevalence, screening, diagnosis, treatment, drugs, and psychotherapy...
September 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28516971/salivary-biomarkers-and-proteomics-future-diagnostic-and-clinical-utilities
#6
M Castagnola, E Scarano, G C Passali, I Messana, T Cabras, F Iavarone, G Di Cintio, A Fiorita, E De Corso, G Paludetti
Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 90% of proteins in weight are derived from the secretion of three couples of "major" glands; all the other components are derived from minor glands, gingival crevicular fluid, mucosal exudates and oral microflora...
April 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28478998/characteristics-and-service-use-of-older-adults-with-schizoaffective-disorder-versus-older-adults-with-schizophrenia-and-bipolar-disorder
#7
Stephanie A Rolin, Kelly A Aschbrenner, Karen L Whiteman, Emily Scherer, Stephen J Bartels
OBJECTIVE: The purpose of this study was to determine if schizoaffective disorder in older adults is differentiated from schizophrenia and bipolar disorder with respect to community functioning, cognitive functioning, psychiatric symptoms, and service use. DESIGN: Secondary analysis of baseline data collected from the Helping Older People Experience Success psychosocial skills training and health management study. SETTING: Three community mental health centers in New Hampshire and Massachusetts...
April 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28447334/-1-h-nmr-1-h-nmr-t2-edited-and-2d-nmr-in-bipolar-disorder-metabolic-profiling
#8
Sumit Sethi, Mariana Pedrini, Lucas B Rizzo, Maiara Zeni-Graiff, Caroline Dal Mas, Ana Cláudia Cassinelli, Mariane N Noto, Elson Asevedo, Quirino Cordeiro, João G M Pontes, Antonio J M Brasil, Acioly Lacerda, Mirian A F Hayashi, Ronei Poppi, Ljubica Tasic, Elisa Brietzke
BACKGROUND: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. METHODS: Metabolomic profiling, employing (1)H-NMR, (1)H-NMR T2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. RESULTS: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28294459/identifying-dynamic-functional-connectivity-biomarkers-using-gig-ica-application-to-schizophrenia-schizoaffective-disorder-and-psychotic-bipolar-disorder
#9
Yuhui Du, Godfrey D Pearlson, Dongdong Lin, Jing Sui, Jiayu Chen, Mustafa Salman, Carol A Tamminga, Elena I Ivleva, John A Sweeney, Matcheri S Keshavan, Brett A Clementz, Juan Bustillo, Vince D Calhoun
Functional magnetic resonance imaging (fMRI) studies have shown altered brain dynamic functional connectivity (DFC) in mental disorders. Here, we aim to explore DFC across a spectrum of symptomatically-related disorders including bipolar disorder with psychosis (BPP), schizoaffective disorder (SAD), and schizophrenia (SZ). We introduce a group information guided independent component analysis procedure to estimate both group-level and subject-specific connectivity states from DFC. Using resting-state fMRI data of 238 healthy controls (HCs), 140 BPP, 132 SAD, and 113 SZ patients, we identified measures differentiating groups from the whole-brain DFC and traditional static functional connectivity (SFC), separately...
May 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28224373/drug-induced-liver-injury-in-the-setting-of-glycogenic-hepatopathy
#10
Valmiki Maharaj, Matthew Fitz, Xianzdong Ding
Glycogenic hepatopathy (GH) is an underdiagnosed complication of uncontrolled type 1 diabetes mellitus (T1DM). It appears as an acute relapsing hepatitis with reversible transaminase elevations secondary to excessive hepatic glycogen accumulation. Patients are often asymptomatic but can present with abdominal pain, nausea and vomiting. Physical examination shows hepatomegaly without splenomegaly. GH is diagnosed by biopsy as it is clinically indistinguishable from non-alcoholic fatty liver disease (NAFLD), a more common cause of hepatic dysfunction in diabetics...
June 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#11
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#12
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28116264/failure-of-polyethelene-insert-locking-mechanism-after-a-posterior-stabilised-total-knee-arthroplasty-a-case-report
#13
Gurava Reddy Ay, Soundar Rajan D, Chiranjeevi T, Karthik C, Krishna Kiran E
INTRODUCTION: Disengagement of polyethylene insert used in total knee arthroplasty is a rare but serious complication. Still rarer is disengagement because of failure of tibial insert locking mechanism. We report a previously unpublished complication of polyethylene insert locking mechanism failure in a 10-months-old posterior stabilized total knee arthroplasty in a 70-year-old woman with osteoarthritis for whom Attune (Depuy) knee implant was used. CASE PRESENTATION: A 70-year-old female underwent (Attune, Depuy) primary bilateral posterior stabilised total knee arthroplasty in a private hospital...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28093821/decreasing-rates-of-pediatric-bipolar-within-an-outpatient-practice
#14
Daniel Wesemann
PROBLEM: Pediatric bipolar disorder (PBD) prevalence is estimated to be 1-3%. Nationally and internationally, rates of PBD have increased by over 400%. However, in Iowa and at one psychiatric clinic in Iowa, from 2008-2013, there was a decrease in PBD diagnosis of 33 and 51.2% respectively. This study examined the diagnosing practices of PBD by local providers in one outpatient mental health center. METHOD: Parents completed a screening packet to differentiate between PBD and attention deficit hyperactivity disorder (ADHD) using three tools: Child Mania Rating Scale (CMRS), Child Behavior Checklist-Mania Scale (CBCL-MS), and the NICHQ Vanderbilt...
January 16, 2017: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/28045094/building-a-genetic-risk-model-for-bipolar-disorder-from-genome-wide-association-data-with-random-forest-algorithm
#15
Li-Chung Chuang, Po-Hsiu Kuo
A genetic risk score could be beneficial in assisting clinical diagnosis for complex diseases with high heritability. With large-scale genome-wide association (GWA) data, the current study constructed a genetic risk model with a machine learning approach for bipolar disorder (BPD). The GWA dataset of BPD from the Genetic Association Information Network was used as the training data for model construction, and the Systematic Treatment Enhancement Program (STEP) GWA data were used as the validation dataset. A random forest algorithm was applied for pre-filtered markers, and variable importance indices were assessed...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27997229/incidence-of-mental-health-diagnoses-in-veterans-of-operations-iraqi-freedom-enduring-freedom-and-new-dawn-2001-2014
#16
Christine Ramsey, James Dziura, Amy C Justice, Hamada Hamid Altalib, Harini Bathulapalli, Matthew Burg, Suzanne Decker, Mary Driscoll, Joseph Goulet, Sally Haskell, Joseph Kulas, Karen H Wang, Kristen Mattocks, Cynthia Brandt
OBJECTIVES: To evaluate gender, age, and race/ethnicity as predictors of incident mental health diagnoses among Operations Iraqi Freedom, Enduring Freedom, and New Dawn veterans. METHODS: We used US Veterans Health Administration (VHA) electronic health records from 2001 to 2014 to examine incidence rates and sociodemographic risk factors for mental health diagnoses among 888 142 veterans. RESULTS: Posttraumatic stress disorder (PTSD) was the most frequently diagnosed mental health condition across gender and age groups...
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27992854/differential-associations-of-affective-temperaments-and-diagnosis-of-major-affective-disorders-with-suicidal-behavior
#17
Ross J Baldessarini, Marco Innamorati, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi, Maurizio Pompili
BACKGROUND: Affective temperaments are associated with suicidal risk, but their predictive value relative to diagnosis of major affective disorder is uncertain. METHODS: We compared diagnoses, affective-temperament ratings (TEMPS-A), and other potential risk factors in 956 psychiatric inpatients, using bivariate analyses and multivariable logistic regression modeling for associations with suicidal status. RESULTS: Lifetime suicide-attempt rates were high (43...
December 13, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936451/onset-polarity-in-bipolar-disorder-a-strong-association-between-first-depressive-episode-and-suicide-attempts
#18
Laura Cremaschi, Bernardo Dell'Osso, Matteo Vismara, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The role of onset polarity (OP) in patients with bipolar disorder (BD) has been increasingly investigated over the last few years, for its clinical, prognostic, and therapeutic implications. The present study sought to assess whether OP was associated with specific correlates, in particular with a differential suicidal risk in BD patients. METHODS: A sample of 362 recovered BD patients was dichotomized by OP: depressed (DO) or elevated onset (EO: hypomanic/manic/mixed)...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27847227/neuropsychological-characteristics-of-child-and-adolescent-offspring-of-patients-with-schizophrenia-or-bipolar-disorder
#19
Elena de la Serna, Gisela Sugranyes, Vanessa Sanchez-Gistau, Elisa Rodriguez-Toscano, Immaculada Baeza, Montserrat Vila, Soledad Romero, Teresa Sanchez-Gutierrez, Mª José Penzol, Dolores Moreno, Josefina Castro-Fornieles
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are considered neurobiological disorders which share some clinical, cognitive and neuroimaging characteristics. Studying child and adolescent offspring of patients diagnosed with bipolar disorder (BDoff) or schizophrenia (SZoff) is regarded as a reliable method for investigating early alterations and vulnerability factors for these disorders. This study compares the neuropsychological characteristics of SZoff, BDoff and a community control offspring group (CC) with the aim of examining shared and differential cognitive characteristics among groups...
November 12, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27834153/childhood-trauma-is-associated-with-increased-brain-responses-to-emotionally-negative-as-compared-with-positive-faces-in-patients-with-psychotic-disorders
#20
M Aas, K Kauppi, C L Brandt, M Tesli, T Kaufmann, N E Steen, I Agartz, L T Westlye, O A Andreassen, I Melle
BACKGROUND: Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders...
November 11, 2016: Psychological Medicine
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