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Bipolar differential diagnosis

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https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#1
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28116264/failure-of-polyethelene-insert-locking-mechanism-after-a-posterior-stabilised-total-knee-arthroplasty-a-case-report
#2
Gurava Reddy Ay, Soundar Rajan D, Chiranjeevi T, Karthik C, Krishna Kiran E
INTRODUCTION: Disengagement of polyethylene insert used in total knee arthroplasty is a rare but serious complication. Still rarer is disengagement because of failure of tibial insert locking mechanism. We report a previously unpublished complication of polyethylene insert locking mechanism failure in a 10-months-old posterior stabilized total knee arthroplasty in a 70-year-old woman with osteoarthritis for whom Attune (Depuy) knee implant was used. CASE PRESENTATION: A 70-year-old female underwent (Attune, Depuy) primary bilateral posterior stabilised total knee arthroplasty in a private hospital...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28093821/decreasing-rates-of-pediatric-bipolar-within-an-outpatient-practice
#3
Daniel Wesemann
PROBLEM: Pediatric bipolar disorder (PBD) prevalence is estimated to be 1-3%. Nationally and internationally, rates of PBD have increased by over 400%. However, in Iowa and at one psychiatric clinic in Iowa, from 2008-2013, there was a decrease in PBD diagnosis of 33 and 51.2% respectively. This study examined the diagnosing practices of PBD by local providers in one outpatient mental health center. METHOD: Parents completed a screening packet to differentiate between PBD and attention deficit hyperactivity disorder (ADHD) using three tools: Child Mania Rating Scale (CMRS), Child Behavior Checklist-Mania Scale (CBCL-MS), and the NICHQ Vanderbilt...
January 16, 2017: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/28045094/building-a-genetic-risk-model-for-bipolar-disorder-from-genome-wide-association-data-with-random-forest-algorithm
#4
Li-Chung Chuang, Po-Hsiu Kuo
A genetic risk score could be beneficial in assisting clinical diagnosis for complex diseases with high heritability. With large-scale genome-wide association (GWA) data, the current study constructed a genetic risk model with a machine learning approach for bipolar disorder (BPD). The GWA dataset of BPD from the Genetic Association Information Network was used as the training data for model construction, and the Systematic Treatment Enhancement Program (STEP) GWA data were used as the validation dataset. A random forest algorithm was applied for pre-filtered markers, and variable importance indices were assessed...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27997229/incidence-of-mental-health-diagnoses-in-veterans-of-operations-iraqi-freedom-enduring-freedom-and-new-dawn-2001-2014
#5
Christine Ramsey, James Dziura, Amy C Justice, Hamada Hamid Altalib, Harini Bathulapalli, Matthew Burg, Suzanne Decker, Mary Driscoll, Joseph Goulet, Sally Haskell, Joseph Kulas, Karen H Wang, Kristen Mattocks, Cynthia Brandt
OBJECTIVES: To evaluate gender, age, and race/ethnicity as predictors of incident mental health diagnoses among Operations Iraqi Freedom, Enduring Freedom, and New Dawn veterans. METHODS: We used US Veterans Health Administration (VHA) electronic health records from 2001 to 2014 to examine incidence rates and sociodemographic risk factors for mental health diagnoses among 888 142 veterans. RESULTS: Posttraumatic stress disorder (PTSD) was the most frequently diagnosed mental health condition across gender and age groups...
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27992854/differential-associations-of-affective-temperaments-and-diagnosis-of-major-affective-disorders-with-suicidal-behavior
#6
Ross J Baldessarini, Marco Innamorati, Denise Erbuto, Gianluca Serafini, Andrea Fiorillo, Mario Amore, Paolo Girardi, Maurizio Pompili
BACKGROUND: Affective temperaments are associated with suicidal risk, but their predictive value relative to diagnosis of major affective disorder is uncertain. METHODS: We compared diagnoses, affective-temperament ratings (TEMPS-A), and other potential risk factors in 956 psychiatric inpatients, using bivariate analyses and multivariable logistic regression modeling for associations with suicidal status. RESULTS: Lifetime suicide-attempt rates were high (43...
December 13, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936451/onset-polarity-in-bipolar-disorder-a-strong-association-between-first-depressive-episode-and-suicide-attempts
#7
Laura Cremaschi, Bernardo Dell'Osso, Matteo Vismara, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The role of onset polarity (OP) in patients with bipolar disorder (BD) has been increasingly investigated over the last few years, for its clinical, prognostic, and therapeutic implications. The present study sought to assess whether OP was associated with specific correlates, in particular with a differential suicidal risk in BD patients. METHODS: A sample of 362 recovered BD patients was dichotomized by OP: depressed (DO) or elevated onset (EO: hypomanic/manic/mixed)...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27847227/neuropsychological-characteristics-of-child-and-adolescent-offspring-of-patients-with-schizophrenia-or-bipolar-disorder
#8
Elena de la Serna, Gisela Sugranyes, Vanessa Sanchez-Gistau, Elisa Rodriguez-Toscano, Immaculada Baeza, Montserrat Vila, Soledad Romero, Teresa Sanchez-Gutierrez, Mª José Penzol, Dolores Moreno, Josefina Castro-Fornieles
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are considered neurobiological disorders which share some clinical, cognitive and neuroimaging characteristics. Studying child and adolescent offspring of patients diagnosed with bipolar disorder (BDoff) or schizophrenia (SZoff) is regarded as a reliable method for investigating early alterations and vulnerability factors for these disorders. This study compares the neuropsychological characteristics of SZoff, BDoff and a community control offspring group (CC) with the aim of examining shared and differential cognitive characteristics among groups...
November 12, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27834153/childhood-trauma-is-associated-with-increased-brain-responses-to-emotionally-negative-as-compared-with-positive-faces-in-patients-with-psychotic-disorders
#9
M Aas, K Kauppi, C L Brandt, M Tesli, T Kaufmann, N E Steen, I Agartz, L T Westlye, O A Andreassen, I Melle
BACKGROUND: Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders...
November 11, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27805985/validity-of-the-associated-symptom-criteria-for-generalized-anxiety-disorder-observations-from-the-singapore-mental-health-study
#10
Siau Pheng Lee, Clarissa Ong, Janhavi Ajit Vaingankar, Siow Ann Chong, Mythily Subramaniam
Previous findings on the diagnostic validity and reliability of generalized anxiety disorder (GAD)-associated symptom criteria suggest need for further evaluation. The current study examined convergent validity and specificity of GAD-associated symptoms in a representative Singapore community sample. The Singapore of Mental Health Study a cross-sectional epidemiological survey conducted among 6166 Singapore residents aged 18 and older. The Composite International Diagnostic Interview version 3.0 was used to diagnose mental disorders...
October 31, 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27772665/-reconciliating-neurology-and-psychiatry-the-prototypical-case-of-frontotemporal-dementia
#11
J Lagarde, M Sarazin
Frontotemporal degeneration (FTD) in its behavioral variant (bvFTD) is probably one of the conditions that best illustrates the links between psychiatry and neurology. It is indeed admitted that between a third and half of patients with this condition, especially in early-onset forms, receive an initial diagnosis of psychiatric disorder (depression, schizophrenia, bipolar disorder) and are then referred to a psychiatric ward. BvFTD can thus be considered a neurological disorder with a psychiatric presentation...
October 20, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27744225/differential-brain-network-activity-across-mood-states-in-bipolar-disorder
#12
Roscoe O Brady, Neeraj Tandon, Grace A Masters, Allison Margolis, Bruce M Cohen, Matcheri Keshavan, Dost Öngür
BACKGROUND: This study aimed to identify how the activity of large-scale brain networks differs between mood states in bipolar disorder. The authors measured spontaneous brain activity in subjects with bipolar disorder in mania and euthymia and compared these states to a healthy comparison population. METHODS: 23 subjects with bipolar disorder type I in a manic episode, 24 euthymic bipolar I subjects, and 23 matched healthy comparison (HC) subjects underwent resting state fMRI scans...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27735972/pediatric-bipolar-disorder
#13
Terry Lee
The diagnosis of bipolar disorder (BD) in youth is confusing and controversial. Controversy notwithstanding, youth diagnosed with BD have high behavioral health needs and are at elevated risk for problematic long-term psychosocial functioning and complex psychiatric medication regimens. Pediatricians and other primary care providers (PCPs) can play an important role in the assessment and treatment of youth diagnosed with BD and the recently created and also controversial diagnosis of disruptive mood dysregulation disorder (DMDD)...
October 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27733585/monotherapy-with-major-antihypertensive-drug-classes-and-risk-of-hospital-admissions-for-mood-disorders
#14
Angela H Boal, Daniel J Smith, Linsay McCallum, Scott Muir, Rhian M Touyz, Anna F Dominiczak, Sandosh Padmanabhan
Major depressive and bipolar disorders predispose to atherosclerosis, and there is accruing data from animal model, epidemiological, and genomic studies that commonly used antihypertensive drugs may have a role in the pathogenesis or course of mood disorders. In this study, we propose to determine whether antihypertensive drugs have an impact on mood disorders through the analysis of patients on monotherapy with different classes of antihypertensive drugs from a large hospital database of 525 046 patients with follow-up for 5 years...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27710902/childhood-trauma-and-hpa-axis-functionality-in-offspring-of-bipolar-parents
#15
Merel M Schreuder, Christiaan H Vinkers, Esther Mesman, Stephan Claes, Willem A Nolen, Manon H J Hillegers
Children of a parent with bipolar disorder (bipolar offspring) have an increased risk for mood disorders. While genetic factors play a significant role in this population, susceptibility to environmental stress may also significantly contribute to this vulnerability for mood disorders. Childhood trauma has consistently been found to increase the risk for mood disorders, with persisting consequences for hypothalamic-pituitary-adrenal (HPA) axis functionality. However, it is currently unknown whether childhood trauma specifically affects HPA axis activity in individuals with a familial risk for bipolar disorder...
December 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27701407/gene-expression-alterations-related-to-mania-and-psychosis-in-peripheral-blood-of-patients-with-a-first-episode-of-psychosis
#16
E S Gouvea, V K Ota, C Noto, M L Santoro, L M Spindola, P N Moretti, C M Carvalho, G Xavier, A C Rios, J R Sato, M A F Hayashi, E Brietzke, A Gadelha, R A Bressan, Q Cordeiro, S I Belangero
Psychotic disorders affect ~3% of the general population and are among the most severe forms of mental diseases. In early stages of psychosis, clinical aspects may be difficult to distinguish from one another. Undifferentiated psychopathology at the first-episode of psychosis (FEP) highlights the need for biomarkers that can improve and refine differential diagnosis. We investigated gene expression differences between patients with FEP-schizophrenia spectrum (SCZ; N=53) or FEP-Mania (BD; N=16) and healthy controls (N=73)...
October 4, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27624435/child-behavior-checklist-profiles-in-adolescents-with-bipolar-and-depressive-disorders
#17
Kukju Kweon, Hyun-Jeong Lee, Kee Jeong Park, Yeonho Joo, Hyo-Won Kim
OBJECTIVE: We aimed to evaluate the Child Behavior Checklist (CBCL) profiles in youths with bipolar and depressive disorders. METHODS: Seventy-four subjects with a mean age of 14.9±1.6years (36 boys) with mood disorders and their parents were recruited from September 2011 to June 2013 in the Department of Psychiatry, Asan Medical Center, Seoul, Korea. Diagnosis of mood disorder and comorbid psychiatric disorder was confirmed by child psychiatrists using the Schedule for Affective Disorders and Schizophrenia for School Age Children - Present and Lifetime version (K-SADS-PL)...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27622393/towards-person-centered-neuroimaging-markers-for-resilience-and-vulnerability-in-bipolar-disorder
#18
Sophia Frangou, Danai Dima, Jigar Jogia
Improved clinical care for Bipolar Disorder (BD) relies on the identification of diagnostic markers that can reliably detect disease-related signals in clinically heterogeneous populations. At the very least, diagnostic markers should be able to differentiate patients with BD from healthy individuals and from individuals at familial risk for BD who either remain well or develop other psychopathology, most commonly Major Depressive Disorder (MDD). These issues are particularly pertinent to the development of translational applications of neuroimaging as they represent challenges for which clinical observation alone is insufficient...
January 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27613282/ratio-of-mbdnf-to-probdnf-for-differential-diagnosis-of-major-depressive-disorder-and-bipolar-depression
#19
Guoqing Zhao, Chen Zhang, Jun Chen, Yousong Su, Rubai Zhou, Fan Wang, Weiping Xia, Jia Huang, Zuowei Wang, Yingyan Hu, Lan Cao, Xiaoyun Guo, Chengmei Yuan, Yong Wang, Zhenghui Yi, Weihong Lu, Yan Wu, Zhiguo Wu, Wu Hong, Daihui Peng, Yiru Fang
There is a high rate of misdiagnosis between major depressive disorder (MDD) and bipolar disorder (BD) in clinical practice. Our previous work provided suggestive evidence for brain-derived neurotrophic factor (BDNF) in differentiating BD from MDD. In this study, we aimed to investigate the role of mature BDNF (mBDNF) and its precursor (proBDNF) in distinguishing bipolar depression (BP) from MDD during acute depressive episode. A total of 105 participants, including 44 healthy controls, 37 MDD patients and 24 BP patients, were recruited...
September 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27611723/the-international-mood-network-imn-nosology-project-differentiating-borderline-personality-from-bipolar-illness
#20
P A Vöhringer, S A Barroilhet, K Alvear, S Medina, C Espinosa, K Alexandrovich, P Riumallo, F Leiva, M E Hurtado, J Cabrera, M Sullivan, N Holtzman, S N Ghaemi
OBJECTIVE: The differential diagnosis of bipolar illness vs. borderline personality is controversial. Both conditions manifest impulsive behavior, unstable interpersonal relationships, and mood symptoms. This study examines whether and which mood clinical features can differentiate between both conditions. METHOD: A total of 260 patients (mean ± standard deviation age 41 ± 13 years, 68% female) attending to a mood clinic were examined for diagnosis of bipolar illness and borderline personality disorder using SCID-I, SCID-II, and clinical mood criteria extracted from Mood Disorder Questionnaire (MDQ)...
December 2016: Acta Psychiatrica Scandinavica
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