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https://www.readbyqxmd.com/read/28231060/improving-quality-in-the-preanalytical-phase-through-innovation-on-behalf-of-the-european-federation-for-clinical-chemistry-and-laboratory-medicine-eflm-working-group-for-preanalytical-phase-wg-pre
#1
Giuseppe Lippi, Geoffrey S Baird, Giuseppe Banfi, Karin Bölenius, Janne Cadamuro, Stephen Church, Michael P Cornes, Anna Dacey, Antoine Guillon, Georg Hoffmann, Mads Nybo, Lakdasa Devananda Premawardhana, María Salinas, Sverre Sandberg, Robbert Slingerland, Ana Stankovic, Sylte Marit Sverresdotter, Pieter Vermeersch, Ana-Maria Simundic
It is now undeniable that laboratory testing is vital for the diagnosis, prognostication and therapeutic monitoring of human disease. Despite the many advances made for achieving a high degree of quality and safety in the analytical part of diagnostic testing, many hurdles in the total testing process remain, especially in the preanalytical phase ranging from test ordering to obtaining and managing the biological specimens. The Working Group for the Preanalytical Phase (WG-PRE) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has planned many activities aimed at mitigating the vulnerability of the preanalytical phase, including the organization of three European meetings in the past 7 years...
February 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28230644/expanding-the-donor-pool-through-intensive-care-to-facilitate-organ-donation-results-of-a-spanish-multicenter-study
#2
Beatriz Domínguez-Gil, Elisabeth Coll, José Elizalde, Jaime E Herrero, Teresa Pont, Brígida Quindós, Bella Marcelo, María A Bodí, Adolfo Martínez, Agustín Nebra, Francisco Guerrero, José M Manciño, Juan Galán, Miguel Lebrón, Eduardo Miñambres, Rafael Matesanz
BACKGROUND: Intensive Care to facilitate Organ Donation (ICOD) may help to increase the donor pool. We describe the Spanish experience with ICOD. METHODS: ACCORD-Spain consisted of an audit of the donation pathway from patients dead as a result of a devastating brain injury (possible donors) in 68 hospitals during 11/1/2014-4/30/2015. We focused on possible donors whose family was interviewed to discuss organ donation once intensive care with a therapeutic purpose was deemed futile and brain death (BD) was a likely outcome...
February 23, 2017: Transplantation
https://www.readbyqxmd.com/read/28226066/chlamydia-trachomatis-infection-in-young-pregnant-women-in-southern-brazil-a-cross-sectional-study
#3
Mariângela Freitas da Silveira, Iândora Krolow Timm Sclowitz, Ludmila Gonçalves Entiauspe, Marilia Arndt Mesenburg, Dulce Stauffert, Guilherme Lucas de Oliveira Bicca, Carine Pieniz, Adriane Brod Manta
This study estimated the prevalence of Chlamydia trachomatis infection during pregnancy in a sample of women up to 29 years of age in the city of Pelotas, Rio Grande do Sul State, Brazil, and investigated socio-demographic risk factors such as maternal age, marital status, maternal schooling, and family income. C. trachomatis infection was diagnosed with PCR using BD ProbeTecTM CT/GC Amplified DNA Assay. Socio-demographic, behavioral, and reproductive data were collected using structured questionnaires. All collections were performed by previously trained medical students...
February 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28223848/severe-panuveitis-in-neuro-beh%C3%A3-et-s-disease-in-malaysia-a-case-series
#4
Khairuddin Othman, Ahmad Tajudin Liza-Sharmini, Mohtar Ibrahim, John Tharakan, Ryoji Yanai, Embong Zunaina
Behçet's disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet's. Neuro-Behçet's is one of the most serious causes of long-term morbidity and mortality. We report two cases of neuro-Behçet's associated with uveitis (ocular BD) highlighting the clinical presentation, diagnostic measurement, and therapeutic management of these cases.
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28222534/a-meta-analysis-of-memantine-for%C3%A2-depression
#5
Taro Kishi, Shinji Matsunaga, Nakao Iwata
We conducted a systematic review and meta-analysis on whether memantine was beneficial for the treatment of depressive symptoms in major depressive disorder (MDD) and bipolar disorder (BD). The analysis included double-blind, randomized, placebo-controlled trials of memantine in MDD and BD. The primary outcome measures for efficacy and safety were response rate and all-cause discontinuation, respectively. Risk ratio (RR) and standardized mean difference with 95% confidence intervals (95% CI) were calculated...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222346/inhibitory-control-in-euthymic-bipolar-disorder-event-related-potentials-during-a-go-nogo-task
#6
A M Morsel, M Dhar, W Hulstijn, A Temmerman, M Morrens, B Sabbe
OBJECTIVES: Patients with bipolar disorder (BD) are reported to have difficulties with inhibition, even in a euthymic state. However, the literature on cortical activity associated with response inhibition in BD remains ambiguous. This study investigates inhibition in euthymic BD using electrophysiological measures, while controlling for effects of specific medications. METHODS: Twenty patients with BD were compared with eighteen healthy controls on a Go/NoGo task while electroencephalogram was recorded...
December 18, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28222054/ucp2-expression-is-increased-in-pancreas-from-brain-dead-donors-and-involved-in-cytokine-induced-%C3%AE-cells-apoptosis
#7
Leticia A Brondani, Tatiana H Rech, Gabriela Boelter, Andrea C Bauer, Cristiane B Leitão, Décio L Eizirik, Daisy Crispim
BACKGROUND: Systemic inflammation associated with brain death (BD) decreases islet yield and quality, negatively affecting outcomes of human islet transplantation. A recent study from our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with BD as compared with controls. UCP2 is located in the mitochondrial inner membrane and regulates production of reactive oxygen species and glucose-stimulated insulin secretion. It has been suggested that UCP2 also plays a role in β cell apoptosis, but these findings remain controversial...
March 2017: Transplantation
https://www.readbyqxmd.com/read/28220797/elevated-choline-containing-compound-levels-in-rapid-cycling-bipolar-disorder
#8
Bo Cao, Jeffrey A Stanley, Ives Cavalcante Passos, Benson Mwangi, Sudhakar Selvaraj, Giovana B Zunta-Soares, Jair C Soares
Previous studies have found increased levels of choline-containing compounds [ie, glycerophosphocholine plus phosphocholine (GPC+PC)] in bipolar disorder using in vivo proton magnetic resonance spectroscopy (¹H MRS), especially in bipolar I disorder (BD-I). Increased levels of GPC+PC suggest alterations in the membrane phospholipids metabolism in bipolar disorder. Rapid cycling (RC) bipolar disorder is considered as a severe course of bipolar disorder, but it is unclear whether rapid cycling bipolar disorder is linked to highly altered membrane phospholipid metabolism...
February 21, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#9
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28215508/biocatalyst-mediated-production-of-11-15-dihydroxy-derivatives-of-androst-1-4-dien-3-17-dione
#10
Yuqian Qiao, Yanbing Shen, Wei Huang, Yanping Wang, Jiajia Ren, Ting Xia, Min Wang
Hydroxylation of steroids at various positions is a powerful tool for the production of valuable pharmaceutical ingredients and precursors. Our paper reported the synchronous dihydroxylation of an efficient strain, i.e., Colletotrichum lini AS3.4486, at two points. C. lini AS3.4486 was selected from 10 strains; this strain can catalyze the dihydroxylation of androst-1,4-dien-3,17-dione at C-11α and C-15α positions. Transformation of ADD(I) by C. lini AS3.4486 produced metabolites II-IV. The structures of these compounds were elucidated by liquid chromatography-mass spectrometry (LC-MS), Fourier Transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and X-ray as 15-hydroxyandrost-1,4-dien-3,17-dione (15α-OH-ADD; II), 11,15-dihydroxyandrost-1,4-dien-3,17-dione (11,15-diOH-ADD; III), and 15,17β-dihy-droxyandrost-1,4-dien-3-one (15-OH-BD; BD is the abbreviation of boldenone; IV)...
February 17, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28214779/lithium-response-in-bipolar-disorder-no-difference-in-gadl1-gene-expression-between-cell-lines-from-excellent-responders-and-non-responders
#11
Jeverson Moreira, Cindie Courtin, Pierre A Geoffroy, Emmanuel Curis, Frank Bellivier, Cynthia Marie-Claire
Previous association studies have shown mixed results between glutamic acid decarboxylase like-1 (GADL1) gene polymorphism and prophylactic lithium response in bipolar disorder (BD) patients. In the present study, GADL1 gene expression was investigated in regard to lithium response, using Alda scale, in lymphoblastoid cells (LCLs) of 36 Caucasian BD patients. No difference in GADL1 expression was observed among LCLs from excellent-responders, non-responders or controls. Furthermore, lithium did not induce significant changes in GADL1 expression levels after 4 or 8 days...
February 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214114/effects-of-salvage-logging-on-soil-properties-and-vegetation-recovery-in-a-fire-affected-mediterranean-forest-a-two-year-monitoring-research
#12
F García-Orenes, V Arcenegui, K Chrenková, J Mataix-Solera, J Moltó, A B Jara-Navarro, M P Torres
Post-fire management can have an additional impact on the ecosystem; in some cases, even more severe than the fire. Salvage logging (SL) is a common practice in most fire-affected areas. The management of burnt wood can determine microclimatic conditions and seriously affect soil properties. In some cases, the way of doing it, using heavy machinery, and the vulnerability of soils to erosion and degradation can make this management potentially aggressive to soil. Research was done in "Sierra de Mariola Natural Park" (E Spain)...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28213545/antifungal-bacteria-on-woodland-salamander-skin-exhibit-high-taxonomic-diversity-and-geographic-variability
#13
Carly R Muletz-Wolz, Graziella V DiRenzo, Stephanie A Yarwood, Evan H Campbell Grant, Robert C Fleischer, Karen R Lips
Diverse bacteria inhabit amphibian skin, some of which inhibit growth of the fungal pathogen, Batrachochytrium dendrobatidis (Bd). Yet, there has been no systematic survey of anti-Bd bacteria across localities, species and elevations. This is important given geographic and taxonomic variation in amphibian susceptibility to Bd. Our sites were within the Appalachian Mountains where previous sampling indicated low Bd prevalence. We determined the number and identity of anti-Bd bacteria on 61 Plethodon salamanders (37 P...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28212261/passage-of-gallstones-into-common-bile-duct-during-laparoscopic-cholecystectomy-is-it-surgeon-s-responsibility
#14
Mohammed Bani Hani, Abdel Rahman Al Manasra, Haitham Qandeel
PURPOSE: Gallstones patients without preoperative history of jaundice, deranged liver function tests, or dilated bile ducts (BD) are unlikely to have BD stones. However, some of these patients in our series underwent endoscopic stone(s) removal after laparoscopic cholecystectomy (LC). We aim to find the incidence, possible intraoperative risk factors, and if the Surgeon can be blamed for this event. MATERIALS AND METHODS: We studied LC cases over 12-year period at our university hospital and identified patients who did not have preoperative risk factors for BD stones but developed postoperative jaundice and/or persistent abdominal pain...
February 16, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28211553/the-assessment-of-schizotypy-by-the-o-life-oxford-liverpool-inventory-for-feelings-and-experiences-in-patients-with-schizophrenia-and-affective-disorders
#15
Daria Dembińska-Krajewska, Janusz Rybakowski
OBJECTIVES: The aim of the study was to assess schizotypy by using the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), in the groups of patients with schizophrenia, bipolar disorder (BD) and unipolar (recurrent) depression (UD). An important element of the study was to compare - in terms of similarity - the results obtained in schizophrenia and BD, and - in terms of differences - the results obtained in BD and UD. METHODS: The study involved 58 patients with schizophrenia (35 men, 23 women, mean age = 34...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28210071/update-on-the-medical-management-of-gastrointestinal-beh%C3%A3-et-s-disease
#16
REVIEW
Giuseppe Lopalco, Donato Rigante, Vincenzo Venerito, Claudia Fabiani, Rossella Franceschini, Michele Barone, Giovanni Lapadula, Mauro Galeazzi, Bruno Frediani, Florenzo Iannone, Luca Cantarini
Behçet's disease (BD) is a multisystemic disorder of unknown etiology mainly defined by recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis, all of which represent the "stigmata" of disease. However, many other organs including the vascular, neurological, musculoskeletal, and gastrointestinal systems can be affected. The gastrointestinal involvement in Behçet's disease (GIBD), along with the neurological and vascular ones, represents the most feared clinical manifestation of BD and shares many symptoms with inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28209156/breastdefend-enhances-effect-of-tamoxifen-in-estrogen-receptor-positive-human-breast-cancer-in-vitro-and-in-vivo
#17
Shujie Cheng, Victor Castillo, Matt Welty, Mark Alvarado, Isaac Eliaz, Constance J Temm, George E Sandusky, Daniel Sliva
BACKGROUND: Tamoxifen (TAM) has been widely used for the treatment of estrogen receptor (ER)-positive breast cancer and its combination with other therapies is being actively investigated as a way to increase efficacy and decrease side effects. Here, we evaluate the therapeutic potential of co-treatment with TAM and BreastDefend (BD), a dietary supplement formula, in ER-positive human breast cancer. METHODS: Cell proliferation and apoptosis were determined in ER-positive human breast cancer cells MCF-7 by MTT assay, quantitation of cytoplasmic histone-associated DNA fragments and expression of cleaved PARP, respectively...
February 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28208976/dexamethasone-as-an-adjuvant-to-bupivacaine-in-supraclavicular-brachial-plexus-block-in-paediatrics-for-post-operative-analgesia
#18
Karl Sa Ribeiro, Anjali Ollapally, Julie Misquith
INTRODUCTION: Sensory blockade of the brachial plexus with local anaesthetics for perioperative analgesia leads to stable haemodynamics intraoperatively, smoother emergence from general anaesthesia and decreased need for supplemental analgesics or suppositories in the Post-operative period. However, increasing the duration of local anaesthetic action is often desirable because it prolongs surgical anaesthesia and analgesia. Various studies in adults prove that steroids increase the duration of action of local anaesthetics when used as adjuncts...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208043/the-australasian-diabetes-data-network-first-national-audit-of-children-and-adolescents-with-type-1-diabetes
#19
Helen Phelan, Helen Clapin, Loren Bruns, Fergus J Cameron, Andrew M Cotterill, Jennifer J Couper, Elizabeth A Davis, Kim C Donaghue, Craig A Jefferies, Bruce R King, Richard O Sinnott, Elaine B Tham, Jerry K Wales, Timothy W Jones, Maria E Craig
OBJECTIVES: To assess glycaemic control, anthropometry and insulin regimens in a national sample of Australian children and adolescents with type 1 diabetes. DESIGN: Cross-sectional analysis of de-identified, prospectively collected data from the Australasian Diabetes Data Network (ADDN) registry. SETTING: Five paediatric diabetes centres in New South Wales, Queensland, South Australia, Victoria and Western Australia. PARTICIPANTS: Children and adolescents (aged 18 years or under) with type 1 diabetes of at least 12 months' duration for whom data were added to the ADDN registry during 2015...
February 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28207918/disruptive-mood-dysregulation-disorder-and-its-effect-on-bipolar-disorder
#20
Shama Faheem, Victoria Petti, George Mellos
BACKGROUND: In the last few decades, a noticeable increase in the diagnosis of bipolar disorder (BD) in youth has raised concerns, particularly because of a consequent increase in the use of psychotropic medications with adverse side effects. After observing the development of those youth into adulthood, clinicians and researchers have questioned the notion of expanding the diagnostic boundaries of BD to encapsulate these youth. METHODS: Our research is aimed at gleaning further information on disruptive mood dysregulation disorder (DMDD) and to observe whether its introduction has affected the rates of BD in children and adolescents...
February 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
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