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https://www.readbyqxmd.com/read/29345745/comparison-of-flow-cytometric-methods-for-the-enumeration-of-residual-leucocytes-in-leucoreduced-blood-products-a-multicenter-study
#1
Yang Zeng, Michelle Dabay, Virginia George, Shalini Seetharaman, Monika de Arruda Indig, Sharon Graminske, Nicole Kimpel, Anna Schmidt, Amanda Boerner, Sarai Paradiso, Tatyana Delman, Yunyao Li, Viktoriya Litvak, Farzad Oreizy, Angela Chen, Maryam Saleminik, Fred Mosqueda, Anna Lin, Kevin Judge
The BD FACSVia™ System features novel designs in hardware, software, and instrument QC. We compared the performance of the BD FACSVia System using the BD Leucocount™ kit with the BD FACSCalibur™ flow cytometer. Leucoreduced platelet (PLT, n = 252) and red blood cell (RBC, n = 278) specimens were enrolled at four sites. Each specimen was stained in four tubes using the BD Leucocount kit reagents and acquired on the two systems. BD Leucocount Control cells (high and low) were used to evaluate the inter-site reproducibility on the BD FACSVia System at three sites over 20 days...
January 18, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29344532/functional-ability-of-clients-with-bipolar-disorders-in-tertiary-hospital-puducherry
#2
Rajendran Rangasamy Kavitha, Sethuramachandran Kamalam, Ravi Philip Rajkumar
Background: Bipolar Disorder (BD) is a common long standing mental illness which is episodic in nature, affecting approximately1-2% of the world adult population. BD frequently affects the patient's life. Few studies have examined the functional impairment in patients with affective illness. The main objective of the current study was to assess specific domains of functioning as well as the overall functioning of the clients with BD. Methods: This cross-sectional study aimed to assess the level of function among the clients with BD in JIPMER Hospital, Puducherry during 2015-2016 and to identify the socio- demographic and clinical factors associated with the level of functioning...
January 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29343875/-trazodone-prolonged-release-in-bipolar-disorder-ii-obsessive-compulsive-disorder-comorbidity-a-case-report
#3
Liliana Lorettu, Giampiero Meli, Elena Antonioli, Antonio Zeppa, Paolo Milia, Alessandra Nivoli
Approximately 21% of patients with bipolar disorder (BD) also have an additional diagnosis of obsessive-compulsive disorder (OCD). This condition is associated with a more severe prognosis and complicates the treatment of BD. In our case report we provide documentary evidence of our experience with trazodone prolonged release in the treatment of depressive phase in a patient with BD II-OCD comorbidity. Rationality in the choise of treatment was based on the need to manage depressive and obsessive symptoms without facilitating hypomania switches...
November 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29343313/eucalyptus-leaves-powder-antibiotic-and-probiotic-addition-to-broiler-diets-effect-on-growth-performance-immune-response-blood-components-and-carcass-traits
#4
H Mashayekhi, M Mazhari, O Esmaeilipour
The study was conducted to investigate the effects of different levels of eucalyptus powder (EP), virginiamycin and probiotic on performance, immunity, blood components and carcass traits of broiler chickens. A total of 250, 1-day-old male broiler chickens (Ross 308) were randomly allocated to five treatments with five replicates and 10 chicks each, as a completely randomized design. The dietary treatments consisted of: basal diet (BD), BD+0.25% EP, BD+0.5% EP, BD+0.01% of diet probiotic (Protexin), BD+0.02% of diet antibiotic (virginiamycin)...
January 18, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29343280/pregabalin-versus-placebo-in-targeting-pro-nociceptive-mechanisms-to-prevent-chronic-pain-after-whiplash-injury-in-at-risk-individuals-a-feasibility-study-for-a-randomised-controlled-trial
#5
J Nikles, G Keijzers, G Mitchell, S Schug, R Ware, S A McLean, L Connelly, S Gibson, S F Farrell, M Sterling
BACKGROUND: Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of central sensitization is associated with poor recovery. Pregabalin's effects on central sensitization indicate the potential to prevent or modulate these processes after whiplash injury and to improve health outcomes, but this has not been investigated...
January 17, 2018: Trials
https://www.readbyqxmd.com/read/29342477/-new-challenges-diagnosis-of-brain-death-in-newborn-children-and-adolescents
#6
Florian Masuhr, Christof Dame, Alexander Gratopp, Olaf Hoffmann
BACKGROUND: According to the current update of the German guideline on brain death (BD), participation of paediatricians is now mandatory for the examination of BD in patients younger than 14 years. The present analysis focuses on the previous practice and highlights the challenges that arise from the current update. METHODS: Retrospective evaluation of the patient registry of the German organ procurement organisation (north-eastern bureau) between January, 2001 and December, 2010 with specified paediatric age groups according to the 4th update of the German guideline on BD from the 1st of July 2015...
January 17, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29341909/nanogel-dfo-conjugates-as-a-model-to-investigate-pharmacokinetics-biodistribution-and-iron-chelation-in-vivo
#7
Yan Wang, Zhi Liu, Tien-Min Lin, Shaurya Chanana, May P Xiong
Deferoxamine (DFO) to treat iron overload (IO) has been limited by toxicity issues and short circulation times and it would be desirable to prolong circulation to improve non-transferrin bound iron (NTBI) chelation. In addition, DFO is currently unable to efficiently target the large pool of iron in the liver and spleen. Nanogel-Deferoxamine conjugates (NG-DFO) can prove useful as a model to investigate the pharmacokinetic (PK) properties and biodistribution (BD) behavior of iron-chelating macromolecules and their overall effect on serum ferritin levels...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341499/recommendations-on-diagnostic-tools-for-batrachochytrium-salamandrivorans
#8
V Thomas, M Blooi, P Van Rooij, S Van Praet, E Verbrugghe, E Grasselli, M Lukac, S Smith, F Pasmans, A Martel
Batrachochytrium salamandrivorans (Bsal) poses a major threat to amphibian, and more specifically caudata, diversity. Bsal is currently spreading through Europe, and mitigation measures aimed at stopping its spread and preventing its introduction into naïve environments are urgently needed. Screening for presence of Bsal and diagnosis of Bsal-induced disease in amphibians are essential core components of effective mitigation plans. Therefore, the aim of this study was to present an overview of all Bsal diagnostic tools together with their limitations and to suggest guidelines to allow uniform interpretation...
January 17, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29339689/atherogenic-index-of-plasma-as-a-cardiovascular-risk-marker-in-manic-depressive-and-euthymic-stages-of-bipolar-disorder
#9
Tevfik Kalelioğlu, Pelin Ünalan, Burcu Kök, Şule Sözen, Özge Yüksel, Mustafa Akkuş, Refik Cihnioğlu, Nesrin Karamustafalıoğlu
OBJECTIVE: Individuals with bipolar disorder (BD) frequently suffer from cardiovascular disease (CVD), and it is a leading cause of mortality. Clinicians use routine laboratory tests, including a lipid profile, to predict cardiovascular risk. In addition, a particular lipid ratio, the atherogenic index of plasma (AIP), is a sensitive, new parameter that can be used to assess highrisk groups. To our knowledge, this is the first study evaluating cardiovascular risk via AIP in different stages of BD...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29338960/small-airway-dysfunction-precedes-the-development-of-asthma-in-children-with-allergic-rhinitis
#10
E Skylogianni, M Triga, K Douros, K Bolis, K N Priftis, S Fouzas, M B Anthracopoulos
BACKGROUND: Epidemiological evidence suggests the existence of a direct link between allergic rhinitis (AR) and asthma. Several studies also support the presence of small-airway dysfunction (SAD) in non-asthmatic children with AR. However, it remains unknown whether SAD can predict the progression of AR to asthma. Our objective was to explore the existence of SAD in non-asthmatic children with AR and to assessed its ability to predict the development of asthma. METHODS: Seventy-three 6-year-old children with intermittent moderate-severe AR but without asthma symptoms/medication within the last two years, underwent spirometry and measurement of respiratory resistance (Rrs) and reactance (Xrs) before and after bronchodilation (BD) (300mcg salbutamol)...
January 12, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29338919/agreement-among-magnetic-resonance-imaging-magnetic-resonance-cholangiopancreatography-mri-mrcp-and-endoscopic-ultrasound-eus-in-the-evaluation-of-morphological-features-of-branch-duct-intraductal-papillary-mucinous-neoplasm-bd-ipmn
#11
Laura Uribarri-Gonzalez, Margaret G Keane, Stephen P Pereira, Julio Iglesias-García, J Enrique Dominguez-Muñoz, Jose Lariño-Noia
BACKGROUND/OBJECTIVES: To evaluate the agreement between the imaging modalities MRI-MRCP and EUS in cystic lesions of the pancreas which were thought to be a BD-IPMN. METHODS: Multicenter retrospective study included all patients between 2010 and 2015 with a suspected BD-IPMN who underwent an EUS and MRI-MRCP within 6 months or less of each other. Location, number, size, worrisome features and high-risk stigmata were evaluated. Interobserver agreement was evaluated by Kappa score...
January 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29338494/neural-correlates-of-response-inhibition-in-patients-with-bipolar-disorder-during-acute-vs-remitted-phase
#12
Juliane Kopf, Stefan Glöckner, Martin Schecklmann, Thomas Dresler, Michael M Plichta, Julia Veeh, Sarah Kittel-Schneider, Andreas Reif
OBJECTIVE: Elevated behavioral impulsivity has been shown to be a core feature of bipolar disorder. However, no study has so far investigated impulsivity-related brain activation in patients with BD during acute vs. remitted phase. To address the question whether elevated behavioural impulsivity and its differential neural pathways is a state or trait marker of BD, we employed a combined stop-signal-go/nogo task in 30 controls, 37 depressed and 15 remitted patients who were retested. METHODS: Frontal brain activation was recorded using near-infrared spectroscopy...
January 17, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29338388/novel-fusion-protein-targeting-mitochondrial-dna-improves-pancreatic-islet-functional-potency-and-islet-transplantation-outcomes
#13
Juan S Danobeitia, Peter J Chlebeck, Inna Shokolenko, Xiaobo Ma, Glenn Wilson, Luis A Fernandez
Long-term graft survival is an ongoing challenge in the field of islet transplantation. With the growing demand for transplantable organs, therapies to improve organ quality and reduce the incidence of graft dysfunction are of paramount importance. We evaluated the protective role of a recombinant DNA repair protein targeted to mitochondria (Exscien I-III), as a therapeutic agent using a rodent model of pancreatic islet transplantation. We first investigated the effect of therapy on isolated rat islets cultured with pro-inflammatory cytokines (interleukin-1 β, interferon γ, and tumor necrosis factor α) for 48 h and documented a significant reduction in apoptosis by flow cytometry, improved viability by immunofluorescence, and conserved functional potency in vitro and in vivo in Exscien I-III-treated islets...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29336911/-detection-and-characterization-of-shiga-toxin-producing-escherichia-coli-in-children-treated-at-an-inter-zonal-pediatric-hospital-in-the-city-of-la-plata
#14
Sebastián Oderiz, Gerardo A Leotta, Lucía Galli
Shiga toxin-producing Escherichia coli (STEC) is a foodborne pathogen that can cause watery diarrhea, bloody diarrhea (BD), and hemolytic uremic syndrome (HUS). The objective of this study was to determine the phenotypic and genotypic profiles of STEC strains isolated from children with BD and HUS treated at a pediatric hospital in the city of La Plata in the period 2006-2012, and to establish the clonal relationship of O157:H7 isolates by pulsed field electrophoresis. The percentage of positive samples was 4...
January 11, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29336895/alterations-in-peripheral-fatty-acid-composition-in-bipolar-and-unipolar-depression
#15
Gustavo Scola, Amelia Versace, Adam H Metherel, Luz A Monsalve-Castro, Mary L Phillips, Richard P Bazinet, Ana C Andreazza
BACKGROUND: Lipid metabolism has been shown to play an important role in unipolar and bipolar depression. In this study, we aimed to evaluate levels of fatty acids in patients with unipolar (MDD) and bipolar depression (BDD) in comparison to patients with bipolar disorder in euthymia (BDE) and non-psychiatric controls. METHODS: Levels of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) were assessed in serum of (87) patients with BD (31 euthymic, 22 depressive) or MDD (34) and (31) non-psychiatric controls through GC-FID...
January 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29336190/a-cost-effectiveness-analysis-of-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-versus-gel-for-the-topical-treatment-of-plaque-psoriasis
#16
Peter Foley, Sinead Garrett, Lasse Ryttig
BACKGROUND: Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE: To determine the cost-effectiveness of Cal/BD foam compared with Cal/BD gel from the Australian perspective. METHODS: A Markov model was developed to evaluate the cost-effectiveness of topical Cal/BD foam and gel for the treatment of people with plaque psoriasis...
January 16, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29335772/investigation-on-the-correlation-between-energy-deposition-and-clustered-dna-damage-induced-by-low-energy-electrons
#17
Wei Liu, Zhenyu Tan, Liming Zhang, Christophe Champion
This study presents the correlation between energy deposition and clustered DNA damage, based on a Monte Carlo simulation of the spectrum of direct DNA damage induced by low-energy electrons including the dissociative electron attachment. Clustered DNA damage is classified as simple and complex in terms of the combination of single-strand breaks (SSBs) or double-strand breaks (DSBs) and adjacent base damage (BD). The results show that the energy depositions associated with about 90% of total clustered DNA damage are below 150 eV...
January 15, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29335620/maternal-dominance-and-additive-genetic-effects-in-nile-tilapia-influence-on-growth-fillet-yield-and-body-size-traits
#18
R Joshi, J A Woolliams, The Meuwissen, H M Gjøen
There are only few studies of dominance effects in non-inbred aquaculture species, since commonly used mating designs often have low power to separate dominance, maternal and common environmental effects. Here, a factorial design with reciprocal cross, common rearing of eggs and subsequent lifecycle stages and pedigree assignment using DNA microsatellites was used to separate these effects and estimate dominance (d2) and maternal (m2) ratios in Nile tilapia for six commercial traits. The study included observations on 2524 offspring from 155 full-sib families...
January 16, 2018: Heredity
https://www.readbyqxmd.com/read/29333823/brain-death-and-organ-donation-in-argentine-pediatric-intensive-care-units-a-multicenter-study
#19
Germán Bonetto, Pedro Taffarel, Melisa Gamerman, Facundo Jorro Barón, Carolina Gaviña, Laura Flores, Emanuel Fernández, Andrea Zifferman, Gustavo Debaisi, Marcelo Acerenza, Jorge Selandari, Luis Landry, Ariel Cacciamano, Alfredo Clavel, Patricia Capocasa, Bernardo Calvo, Marcial Angos
Brain death (BD) is a condition determined by the complete and irreversible absence of brain functions. Maintenance of vital functions creates an opportunity for organ donation. A retrospective study was carried out in 7 pediatric intensive care units of Argentina (from 1/1/2013 to 9/30/2016) to determine the incidence of clinical and certified BD, and the proportion of effective transplantations. Among deceased patients, 19.14% (147/768) met the clinical requirements for BD, and the main cause of BD was multiple trauma...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29332930/bullosis-diabeticorum-a-rare-presentation-with-immunoglobulin-g-igg-deposition-related-vasculopathy-case-report-and-focused-review
#20
Hardik Sonani, Sohail Abdul Salim, Vishnu V Garla, Anna Wile, Venkataraman Palabindala
BACKGROUND Bullosis diabeticorum (BD) is a condition characterized by recurrent, spontaneous, and non-inflammatory blistering in patients with poorly controlled diabetes mellitus. While etiopathogenesis remains unclear, roles of neuropathy, vasculopathy and UV light are hypothesized. Most literature reports negative direct and indirect immunofluorescence findings in diabetics with bullous eruptions. Porphyria cutanea tarda, bullous pemphigoid, epidermolysis bullosa, and pseudoporphyria are other differential diagnoses of bullous lesions, and they must be excluded...
January 15, 2018: American Journal of Case Reports
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