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https://www.readbyqxmd.com/read/29782956/attentional-engagement-increases-inferior-frontal-gyrus-activity-and-mutes-limbic-activity-in-pediatric-bipolar-disorder-meta-analyses-of-fmri-studies
#1
Moon-Soo Lee, Purnima Anumagalla, Prasanth Talluri, Mani N Pavuluri
OBJECTIVES: Attentional deficit has been shown to exist in adult and pediatric bipolar disorder across the life span. Given that emotional dysregulation is central to bipolar disorder, this study hypothesizes that emotional circuitry regions are altered along with anomalies in the attentional systems during cognitive deployment in bipolar disorder. METHODS: An activation likelihood estimation meta-analysis of attentional activities using GingerALE software was completed for adult and pediatric bipolar disorder populations in all published studies till December 2017...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29781657/longitudinal-stability-of-cognitive-control-in-early-psychosis-nondegenerative-deficits-across-diagnoses
#2
Jason Smucny, Tyler A Lesh, Ana-Maria Iosif, Tara A Niendam, Laura M Tully, Cameron S Carter
Cognitive impairment, particularly in the domain of cognitive control, is characteristic of schizophrenia (SZ) spectrum and bipolar disorders (BDs). The longitudinal trajectory of these impairments, however, remains unclear. Indeed, some studies have observed degeneration and others stability or even improvement over time in these illnesses. Here we examined the longitudinal stability of the AX-Continuous Performance Task (AX-CPT), a cognitive control task, in 52 patients with recent-onset SZ (<2 years from first study measurement), 20 patients with recent-onset BD Type I with psychotic features, and 70 healthy control subjects...
May 21, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29781424/review-analysis-and-impact-of-co-circulating-h5n1-and-h9n2-avian-influenza-viruses-in-bangladesh
#3
Rokshana Parvin, Jahan Ara Begum, Mohammed Nooruzzaman, Emdadul Haque Chowdhury, Mohammad Rafiqul Islam, Thomas W Vahlenkamp
Almost the full range of 16 haemagglutinin (HA) and nine neuraminidase subtypes of avian influenza viruses (AIVs) has been detected either in waterfowl, land-based poultry or in the environment in Bangladesh. AIV infections in Bangladesh affected a wide range of host species of terrestrial poultry. The highly pathogenic avian influenza (AI) H5N1 and low pathogenic AI H9N2 were found to co-circulate and be well entrenched in the poultry population, which has caused serious damage to the poultry industry since 2007...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29781205/double-trouble-weekend-sleep-changes-are-associated-with-increased-impulsivity-among-adolescents-with-bipolar-i-disorder
#4
Anda Gershon, Sheri L Johnson, Leigh Thomas, Manpreet K Singh
OBJECTIVES: Both sleep disruption and impulsivity are important predictors of the course of bipolar disorder (BD). Although sleep disruption has been shown to intensify impulsivity, little research has considered how these two important domains interact within BD. Adolescence is a critical period for the onset of BD, and is often associated with increases in impulsivity and substantial changes in sleep. We tested the hypothesis that disruptions in sleep would increase impulsivity among adolescents, and that this effect would be more pronounced among those with BD...
May 20, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29780043/-propose-for-the-benchmark-dose-bd-for-the-optimization-of-protection-in-medical-exposure-in-general-radiography
#5
Hiroshi Watanabe, Masashi Seki, Masahiro Nitta, Itsuki Serita, Yoshiaki Maehara, Hideaki Okura, Tomofumi Murakami, Kazuyuki Yamamoto, Tsutomu Sato, Ryuto Tajima
The goal of this research was to create the most appropriate index dose for the optimization of protection in medical exposure in general radiography in Kanagawa prefecture. We distributed questionnaires to 272 medical institutions in Kanagawa prefecture. The investigation period was from October 2015 to February 2016. Entrance surface dose (ESD) was used as the index dose. Investigated regions in general radiography were the adult chest, adult abdomen, and infant chest (anterior-posterior projections for all regions)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29779901/white-matter-disruptions-in-patients-with-bipolar-disorder
#6
Lucija Abramovic, Marco P M Boks, Annabel Vreeker, Sanne Verkooijen, Annet H van Bergen, Roel A Ophoff, René S Kahn, Neeltje E M van Haren
Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics...
May 17, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#7
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29778562/comparison-of-tigecycline-susceptibility-testing-methods-for-multidrug-resistant-acinetobacter-baumannii
#8
Evgeny A Idelevich, Dinah A Freeborn, Harald Seifert, Karsten Becker
Automated systems Vitek 2, BD Phoenix, MicroScan WalkAway and gradient diffusion assays Etest and MIC Test Strip were compared against broth microdilution for susceptibility testing of tigecycline against Acinetobacter baumannii. BD Phoenix and MIC Test Strip seemed to provide the most accurate determination of tigecycline susceptibility.
March 24, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29778070/high-intensity-binge-drinking-is-associated-with-alterations-in-spontaneous-neural-oscillations-in-young-adults
#9
Rifqi O Affan, Siyuan Huang, Stephen M Cruz, Lee A Holcomb, Edward Nguyen, Ksenija Marinkovic
Heavy episodic alcohol consumption (also termed binge drinking) contributes to a wide range of health and cognitive deficits, but the associated brain-based indices are poorly understood. The current study used electroencephalography (EEG) to examine spontaneous neural oscillations in young adults as a function of quantity, frequency, and the pattern of their alcohol consumption. Sixty-one young adults (23.4 ± 3.4 years of age) were assigned to binge drinking (BD) and light drinking (LD) groups that were equated on gender, race/ethnic identity, age, educational background, and family history of alcoholism...
January 8, 2018: Alcohol
https://www.readbyqxmd.com/read/29775773/trimeprazine-is-enantioselectively-degraded-by-an-activated-sludge-in-ready-biodegradability-test-conditions
#10
Laura Escuder-Gilabert, Yolanda Martín-Biosca, Mireia Perez-Baeza, Salvador Sagrado, María José Medina-Hernández
A great number of available pharmaceuticals are chiral compounds. Although they are usually manufactured as racemic mixtures, they can be enantioselectively biodegraded as a result of microbial processes. In this paper, a biodegradability assay in similar conditions to those recommended in OECD tests of enantiomers of trimeprazine (a phenothiazine employed as a racemate) is carried out. Experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant, WWTP) and supplemented with the racemate...
May 9, 2018: Water Research
https://www.readbyqxmd.com/read/29774089/different-options-of-endosonography-guided-biliary-drainage-after-endoscopic-retrograde-cholangio-pancreatography-failure
#11
José Celso Ardengh, César Vivian Lopes, Rafael Kemp, José Sebastião Dos Santos
AIM: To investigate the success rates of endosonography (EUS)-guided biliary drainage (EUS-BD) techniques after endoscopic retrograde cholangiopancreatography (ERCP) failure for management of biliary obstruction. METHODS: From Feb/2010 to Dec/2016, ERCP was performed in 3538 patients, 24 of whom (0.68%) suffered failure to cannulate the biliary tree. All of these patients were initially submitted to EUS-guided rendez-vous (EUS-RV) by means of a transhepatic approach...
May 16, 2018: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29773947/efficacy-safety-and-pharmacokinetics-of-budesonide-formoterol-fumarate-delivered-via-metered-dose-inhaler-using-innovative-co-suspension-delivery-technology-in-patients-with-moderate-to-severe-copd
#12
Edward M Kerwin, Thomas M Siler, Samir Arora, Patrick Darken, Earl Rose, Colin Reisner
Purpose: This study investigated the efficacy, safety, and pharmacokinetics of the inhaled corticosteroid/long-acting β2 -agonist fixed-dose combination budesonide/formoterol fumarate (BFF) metered dose inhaler (MDI), compared with the monocomponents budesonide (BD) MDI and formoterol fumarate (FF) MDI, in patients with moderate-to-severe COPD. Materials and methods: In this Phase IIb, randomized, double-blind, four-period, five-treatment, incomplete-block, crossover study (NCT02196077), all patients received BFF MDI 320/9...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29772266/pten-pdz-binding-domain-suppresses-mammary-carcinogenesis-in-the-mmtv-pymt-breast-cancer-model
#13
Mingfei Yan, Yubing Wang, Chi Wai Wong, Penelope Mei-Yu Or, Kin Lok Wong, Lisha Li, Alexander M Many, Hong Guan, Ui Soon Khoo, Andrew M Chan
Phosphatase and tension homolog (PTEN) is a potent tumor suppressor that possesses a PDZ-binding domain (PDZ-BD) at the end of its carboxyl terminus, whose functions during tumorigenesis remains unclear. Here, we crossed a mouse strain with germline deletion of PTEN PDZ-BD with MMTV-PyMT breast cancer model, and found that knockout (KO) mice display normal development of mammary glands, but have both increased breast tumorigenicity and lung metastasis. Orthotopic allograft experiments suggest the loss of PTEN PDZ-BD in breast cancer cells rather than in tumor microenvironment plays a prominent role in increasing tumor burden...
May 14, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29771599/clinical-characterization-of-children-with-resistant-airflow-obstruction-a-multicenter-study
#14
Sankaran Krishnan, Allen J Dozor, Leonard Bacharier, Jason E Lang, Charles G Irvin, David Kaminsky, Harold J Farber, Lynn Gerald, Mark Brown, Janet T Holbrook, Robert A Wise, Julie Ryu, Sonali Bose, Yasin Razan, Joy Saams, Robert J Henderson, William G Teague
OBJECTIVE: To characterize a cohort of children with airflow limitation resistant to bronchodilator (BD) therapy. METHODS: Pulmonary function tests performed in children 6-17 years of age at 15 centers in a clinical research consortium were screened for resistant airflow limitation, defined as a post-BD FEV1 and/or an FEV1 /FVC less than the lower limits of normal. Demographic and clinical data were analyzed for associations with pulmonary function. RESULTS: 582 children were identified...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29768190/a-bayesian-model-comparison-approach-to-test-the-specificity-of-visual-integration-impairment-in-schizophrenia-or-psychosis
#15
Tyler B Grove, Beier Yao, Savanna A Mueller, Merranda McLaughlin, Vicki L Ellingrod, Melvin G McInnis, Stephan F Taylor, Patricia J Deldin, Ivy F Tso
Impaired visual integration is well documented in schizophrenia and related to functional outcomes. However, it is unclear if this deficit is specific to schizophrenia, or characteristic of psychosis more broadly. To address this question, this study used a Bayesian model comparison approach to examine the evidence of three grouping models of visual integration performance in 116 individuals with schizophrenia (SZ), schizoaffective disorder (SA), bipolar disorder (BD) with or without a history of prominent psychosis (BDP+ and BDP-, respectively), or no psychiatric diagnosis (healthy controls; HC)...
May 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29767073/magnolol-additive-as-a-replacer-of-antibiotic-enhances-the-growth-performance-of-linwu-ducks
#16
Qian Lin, Jianfei Zhao, Kun Xie, Yushi Wang, Guili Hu, Guitao Jiang, Qiuzhong Dai, Zhiyong Fan, Jianhua He, Xi He, De-Xing Hou
Magnolol rich in Magnolia officinalis is a bioactive polyphenolic compound. The aim of this study was to examine the effects of magnolol additive (MA) on growth performance, expression levels of antioxidant-related genes, and intestinal mucosal morphology of Linwu ducks aged from 49 to 70 days, comparing with that of an antibiotic additive (colistin sulfate [CS]). A total of 275, 49-day-old ducks were assigned to 5 groups with 5 cages of 11 ducks each and fed diets supplemented with 0, 100, 200 and 300 mg of MA/kg and 300 mg of CS/kg for 3 weeks, respectively...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766490/emotional-hyper-reactivity-and-cardiometabolic-risk-in-remitted-bipolar-patients-a-machine-learning-approach
#17
A A Dargél, F Roussel, S Volant, B Etain, R Grant, J-M Azorin, K M'Bailara, F Bellivier, T Bougerol, J-P Kahn, P Roux, V Aubin, P Courtet, M Leboyer, F Kapczinski, C Henry
OBJECTIVE: Remitted bipolar disorder (BD) patients frequently present with chronic mood instability and emotional hyper-reactivity, associated with poor psychosocial functioning and low-grade inflammation. We investigated emotional hyper-reactivity as a dimension for characterization of remitted BD patients, and clinical and biological factors for identifying those with and without emotional hyper-reactivity. METHOD: A total of 635 adult remitted BD patients, evaluated in the French Network of Bipolar Expert Centers from 2010-2015, were assessed for emotional reactivity using the Multidimensional Assessment of Thymic States...
May 15, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29765909/shiga-toxin-producing-escherichia-coli-infection-in-j%C3%A3-nk%C3%A3-ping-county-sweden-occurrence-and-molecular-characteristics-in-correlation-with-clinical-symptoms-and-duration-of-stx-shedding
#18
Xiangning Bai, Sara Mernelius, Cecilia Jernberg, Ing-Marie Einemo, Stefan Monecke, Ralf Ehricht, Sture Löfgren, Andreas Matussek
Shiga toxin-producing Escherichia coli (STEC) cause bloody diarrhea (BD), hemorrhagic colitis (HC), and even hemolytic uremic syndrome (HUS). In Nordic countries, STEC are widely spread and usually associated with gastrointestinal symptoms and HUS. The objective of this study was to investigate the occurrence of STEC in Swedish patients over 10 years of age from 2003 through 2015, and to analyze the correlation of critical STEC virulence factors with clinical symptoms and duration of stx shedding. Diarrheal stool samples were screened for presence of stx by real-time PCR...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29765205/patterns-of-persistence-with-pharmacological-treatment-among-patients-with-current-depressive-episode-and-their-impact-on-long-term-outcome-a-naturalistic-study-with-5-year-follow-up
#19
Kanglai Li, Jiong Tao, Yuemei Li, Minhua Chen, Xiuhua Wu, Yingtao Liao, Xiaolan Lin, Zhaoyu Gan
Background: The aim of the study was to describe and compare the patterns of medication persistence among patients with unipolar depression (UD) or bipolar depression in a 5-year follow-up, and explore their impact on long-term outcome. Patients and methods: A total of 333 eligible patients with current major depressive episode were observed and followed up from the first index prescription for 5 years. Lack of persistence or treatment interruption was defined as a gap of at least 2 consecutive months without taking any medication...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29763689/surface-engineered-excipients-ii-simultaneous-milling-and-dry-coating-for-preparation-of-fine-grade-microcrystalline-cellulose-with-enhanced-properties
#20
Liang Chen, Xiaoyi Ding, Zizhou He, Siqi Fan, Kuriakose T Kunnath, Kai Zheng, Rajesh N Davé
A solventless process for simultaneously milling and dry coating microcrystalline cellulose (MCC) was investigated for producing fine excipients in five different sizes (∼20, 25, 30, 35, 40µm) having high bulk density (BD), good flow function coefficient (FFC), and excellent compaction. Avicel PH-102, used as the starting material, was milled and coated with two grades of silicas, hydrophobic and hydrophilic (R972P and A200), using a fluid energy mill (FEM). Through judicious selection of the FEM feed rate, feeding pressure, and grinding pressure, five desired milled sizes were produced...
May 12, 2018: International Journal of Pharmaceutics
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