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https://www.readbyqxmd.com/read/28433948/metabolic-syndrome-in-subjects-with-bipolar-disorder-and-major-depressive-disorder-in-a-current-depressive-episode-population-based-study-metabolic-syndrome-in-current-depressive-episode
#1
Fernanda Pedrotti Moreira, Karen Jansen, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Jean Pierre Oses, Carolina David Wiener
OBJECTIVE: To assess the differences in the prevalence of the metabolic syndrome (MetS) and their components in young adults with bipolar disorder (BD) and major depressive disorder (MDD) in a current depressive episode. METHODS: This was a cross-sectional study with young adults aged 24-30 years old. Depressive episode (bipolar or unipolar) was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III)...
April 2, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28431814/evaluation-of-storing-hepatitis-b-vaccine-outside-the-cold-chain-in-the-solomon-islands-identifying-opportunities-and-barriers-to-implementation
#2
Lucy Breakwell, Jenniffer Anga, Ibrahim Dadari, Nahad Sadr-Azodi, Divinal Ogaoga, Minal Patel
Monovalent Hepatitis B vaccine (HepB) is heat stable, making it suitable for storage outside cold chain (OCC) at 37°C for 1month. We conducted an OCC project in the Solomon Islands to determine the feasibility of and barriers to national implementation and to evaluate impact on coverage. Healthcare workers at 13 facilities maintained monovalent HepB birth dose (HepB-BD) OCC for up to 28days over 7months. Vaccination data were recorded for children born during the project and those born during 7months before the project...
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28431768/is-there-room-for-luminal-basal-urothelial-cell-population-quantification
#3
G R Passos, J A Camargo, K L Ferrari, G C Franch, A E Nowill, L O Reis
PURPOSE: Three cell layers compose the urothelium: basal, intermediate and luminal ("umbrella cells") and different diseases might arise from different cell populations. The aim of this study is to analyze the quantification ability of such cell populations by using four different protocols. METHODS: Twenty male rats (Wistar) were randomized in four groups of five animals: scraping, enzymatic 30, 45 and 60minutes. The cells were isolated, analyzed by flow cytometer and data processed by BD FACSDIVA™ software...
April 18, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28431226/the-impact-of-automatic-devices-for-capillary-blood-collection-on-efficiency-and-pain-response-in-newborns-a-randomized-controlled-trial
#4
G Sorrentino, M Fumagalli, S Milani, I Cortinovis, A Zorz, G Cavallaro, F Mosca, L Plevani
BACKGROUND: The heel stick is the method of choice in most neonatal units for capillary blood sampling, and it represents the most common event among all painful procedures performed on newborns. The type and design of heel stick device and the clinical procedure to collect a blood sample may have an impact on newborn pain response as well. OBJECTIVE: To compare the pain response and efficiency of different automated devices for capillary blood collection in newborns...
April 11, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28429352/difference-in-resting-state-fractional-amplitude-of-low-frequency-fluctuation-between-bipolar-depression-and-unipolar-depression-patients
#5
H-L Yu, W-B Liu, T Wang, P-Y Huang, L-Y Jie, J-Z Sun, C Wang, W Qian, M Xuan, Q-Q Gu, H Liu, F-L Zhang, M-M Zhang
OBJECTIVE: To investigate the difference in fractional amplitude of low-frequency fluctuation (fALFF) of localized brain activities in the resting-state between bipolar depression and unipolar depression patients and to find biological markers that differentiate the two groups of patients. PATIENTS AND METHODS: Thirteen patients with bipolar depression, 15 patients with unipolar depression, and 16 healthy control subjects that were matched in age and years of education were subjected to 3...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28427473/intestinal-beh%C3%A3-et-and-crohn-s-disease-two-sides-of-the-same-coin
#6
REVIEW
Simona Valenti, Romina Gallizzi, Dominique De Vivo, Claudio Romano
Behçet's disease (BD) and Crohn's disease (CD) are chronic immune-mediated, inflammatory disorders affecting many different systems (joints, skin, eyes, gastrointestinal and biliary tracts). Both disorders have fluctuating courses and when gastrointestinal symptoms are prevalent, differential diagnosis can be difficult. BD involves the gastrointestinal tract in 10-15% of cases with localized lesions in the ileocecal region. The clinical picture is heterogeneous with various clusters of disease expression. CD is a chronic inflammatory disorder, which can affect any part of the intestinal tract, as well as extra-intestinal tissue...
April 20, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28427032/social-cognition-in-bipolar-disorder-focus-on-emotional-intelligence
#7
C Varo, E Jimenez, B Solé, C M Bonnín, C Torrent, E Valls, I Morilla, G Lahera, A Martínez-Arán, E Vieta, M Reinares
BACKGROUND: The present study aims to characterize emotional intelligence (EI) variability in a sample of euthymic bipolar disorder (BD) patients through the Mayer- Salovey-Caruso Emotional Intelligence Test (MSCEIT). METHOD: A total of 134 euthymic BD outpatients were recruited and divided into three groups according to the total Emotional Intelligence Quotient (EIQ) score of the MSCEIT, following a statistical criterion of scores 1.5SDs above/below the normative group mean, as follows: a low performance (LP) group (EIQ <85), a normal performance (NP) group (85≤EIQ≤115), and a high performance (HP) group (EIQ >115)...
April 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28425774/profile-of-the-triplex-assay-for-detection-of-chlamydia-gonorrhea-and-trichomonas-using-the-bd-max%C3%A2-system
#8
Barbara Van Der Pol
Chlamydia, gonorrhea and trichomonas are the most common curable STI. Improved access to testing could reduce infection rates and prevent sequelae. Nucleic acid amplification tests are the recommend class of diagnostic assay for these infections which are often asymptomatic. Areas Covered: A description of the BD MAX™ System (MAX) and the BD MAX CT/GC/TV assay is provided along with data from a large US clinical trial. The capacity of the system for other tests and for lab developed assays is also described...
April 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28425710/solvation-structure-of-1-3-butanediol-in-aqueous-binary-solvents-with-acetonitrile-1-4-dioxane-and-dimethyl-sulfoxide-studied-by-ir-nmr-and-molecular-dynamics-simulation
#9
Toshiyuki Takamuku, Yasuhito Higuma, Masaru Matsugami, Takahiro To, Tatsuya Umecky
The solvation structure of 1,3-butanediol (1,3-BD) in aqueous binary solvents of acetonitrile (AN), 1,4-dioxane (DIO), and dimethyl sulfoxide (DMSO) at various mole fractions of organic solvent xOS has been clarified by means of infrared (IR) and 1H and 13C NMR. The change in the wavenumber of O-H stretching vibration of 1,3-BD in the three systems suggested that water molecules which are initially hydrogen-bonded with the 1,3-BD hydroxyl groups in the water solvent (xOS = 0) are more significantly replaced by organic solvent molecules in the order of DMSO > DIO > AN...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28425424/spatial-distribution-of-batrachochytrium-dendrobatidis-in-south-american-caecilians
#10
Carolina Lambertini, C Guilherme Becker, Cecilia Bardier, Domingos da Silva Leite, Luís Felipe Toledo
The amphibian-killing fungus Batrachochytrium dendrobatidis (Bd) is linked to population declines in anurans and salamanders globally. To date, however, few studies have attempted to screen Bd in live caecilians; Bd-positive caecilians have only been reported in Africa and French Guiana. Here, we performed a retrospective survey of museum preserved specimens to (1) describe spatial patterns of Bd infection in Gymnophiona across South America and (2) test whether areas of low climatic suitability for Bd in anurans predict Bd spatial epidemiology in caecilians...
April 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28425243/the-assessment-of-work-productivity-and-activity-impairment-in-beh%C3%A3-et-s-disease
#11
Gonca Mumcu, Fadime Lehimci, Özlem Fidan, Hülya Gük, Uğur Alpar, Ali Uğur Ünal, Zeynep Ertürk, Fatma Alibaz Öner, Güzide Nevsun Inanç, Safiye Atlas Tulin Ergun, Rafi Haner Direskeneli
BACKGROUND/AIM: The aim of this study was to assess the relationships between the course of Behçet's disease (BD), disease-specific fears, and work productivity and activity impairment. MATERIALS AND METHODS: In this cross-sectional study, 110 consecutive BD patients were included. The Work Productivity and Activity Impairment questionnaire was used. RESULTS: In the group of employed patients, 30.41% had missed work during the previous week...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425102/fatal-overdose-of-gamma-hydroxybutyrate-acid-after-ingestion-of-1-4-butanediol
#12
Erwan Le Garff, Vadim Mesli, Raphael Cornez, Christophe Demarly, Gilles Tournel, Valery Hédouin
We report a case of fatal intoxication from 1,4-butanediol (1,4-BD), which was ingested by a young and "naïve" gamma-hydroxybutyrate (GHB) consumer during a party with the co-ingestion of alcohol, cannabis, and methylene-dioxy-methamphetamine. The following drug concentrations were found using gas chromatography coupled with mass spectrometry on autopsy samples and on a cup and a glass found at the scene: 20,350 mg/L (bottle) for 1,4-BD; 1020 mg/L (femoral blood), 3380 mg/L (cardiac blood), 47,280 mg/L (gastric content), and 570 mg/L (vitreous humor) for GHB...
April 20, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28424893/diversity-in-growth-patterns-among-strains-of-the-lethal-fungal-pathogen-batrachochytrium-dendrobatidis-across-extended-thermal-optima
#13
Jamie Voyles, Leah R Johnson, Jason Rohr, Rochelle Kelly, Carley Barron, Delaney Miller, Josh Minster, Erica Bree Rosenblum
The thermal sensitivities of organisms regulate a wide range of ecological interactions, including host-parasite dynamics. The effect of temperature on disease ecology can be remarkably complex in disease systems where the hosts are ectothermic and where thermal conditions constrain pathogen reproductive rates. Amphibian chytridiomycosis, caused by the pathogen Batrachochytrium dendrobatidis (Bd), is a lethal fungal disease that is influenced by temperature. However, recent temperature studies have produced contradictory findings, suggesting that our current understanding of thermal effects on Bd may be incomplete...
April 19, 2017: Oecologia
https://www.readbyqxmd.com/read/28424132/outcomes-of-recreational-activity-associated-trauma-in-elderly-persons-on-blood-thinning-medications
#14
Zachary M DeBoard, Jonathan Grotts, Lisa Ferrigno
With increasing life expectancy, the elderly are participating in recreational activities traditionally pursued by younger persons. Elderly patients have many reasons for worse outcomes after trauma, one of which may be the rising use of anticoagulant and/or antiplatelet medications. This study aimed to determine whether preinjury use of these agents yielded worse outcomes in geriatric patients injured during high-impact recreational activities. The National Trauma Data Bank was reviewed from 2007 to 2010 for patients ≥65 years admitted to Level I or II trauma centers with ICD-9 E-codes for specific mechanisms of injury...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28423947/metabolic-engineering-strategies-for-acetoin-and-2-3-butanediol-production-advances-and-prospects
#15
Taowei Yang, Zhiming Rao, Xian Zhang, Meijuan Xu, Zhenghong Xu, Shang-Tian Yang
Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28422724/utilizing-combinatorial-engineering-to-develop-tie2-targeting-antagonistic-angiopoetin-2-ligands-as-candidates-for-anti-angiogenesis-therapy
#16
Tomer Shlamkovich, Lidan Aharon, William A Barton, Niv Papo
In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant impact on cancer therapy. Nevertheless, attempts to develop Tie2-targeted inhibitors have met with little success, and there is currently no FDA-approved therapeutic selectively targeting Tie2. We used a combinatorial protein engineering approach to develop a new generation of angiopoietin (Ang) 2-derived Tie2 antagonists as potential cancer therapeutics and as tools to study angiogenesis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421814/elevated-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-endothelial-dysfunction-in-beh%C3%A3-et-disease
#17
Nusret Acikgoz, Ertuğrul Kurtoğlu, Julide Yagmur, Yelda Kapicioglu, Mehmet Cansel, Necip Ermis
Behçet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28421717/cognitive-profiles-in-euthymic-patients-with-bipolar-disorders-results-from-the-face-bd-cohort
#18
Paul Roux, Aurélie Raust, Anne Sophie Cannavo, Valérie Aubin, Bruno Aouizerate, Jean-Michel Azorin, Frank Bellivier, Raoul Belzeaux, Thierry Bougerol, Iréna Cussac, Philippe Courtet, Bruno Etain, Sébastien Gard, Sophie Job, Jean-Pierre Kahn, Marion Leboyer, Emilie Olié, Chantal Henry, Christine Passerieux
OBJECTIVES: Although cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, little is known about cognitive phenotype heterogeneity among patients with BD. METHODS: We investigated neuropsychological performance in 258 euthymic patients with BD recruited via the French network of expert centers for BD. We used a test battery assessing six domains of cognition. Hierarchical cluster analysis of the cross-sectional data was used to determine the optimal number of subgroups and to assign each patient to a specific cognitive cluster...
April 19, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28421309/genetic-makeup-of-shiga-toxin-producing-escherichia-coli-in-relation-to-clinical-symptoms-and-duration-of-shedding-a-microarray-analysis-of-isolates-from-swedish-children
#19
A Matussek, C Jernberg, I-M Einemo, S Monecke, R Ehricht, I Engelmann, S Löfgren, S Mernelius
Shiga toxin (Stx)-producing Escherichia coli (STECs) cause non-bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome, and are the primary cause of acute renal failure in children worldwide. This study investigated the correlation of genetic makeup of STEC strains as revealed by DNA microarray to clinical symptoms and the duration of STEC shedding. All STEC isolated (n = 96) from patients <10 years of age in Jönköping County, Sweden from 2003 to 2015 were included. Isolates were characterized by DNA microarray, including almost 280 genes...
April 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28421189/optic-nerve-sheath-diameter-ultrasound-evaluation-in-intensive-care-unit-possible-role-and-clinical-aspects-in-neurological-critical-patients-daily-monitoring
#20
M Toscano, G Spadetta, P Pulitano, M Rocco, V Di Piero, O Mecarelli, E Vicenzini
Background. The increase of the optic nerve sheath diameter (ONSD) is a reliable, noninvasive sonographic marker of intracranial hypertension. Aim of the study was to demonstrate the efficacy of ONSD evaluation, when monitoring neurocritical patients, to early identify malignant intracranial hypertension in patients with brain death (BD). Methods. Data from ultrasound ONSD evaluation have been retrospectively analyzed in 21 sedated critical patients with neurological diseases who, during their clinical course, developed BD...
2017: BioMed Research International
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