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inflamation and hypertension

Hung-Bo Hsiao, Chang-Chi Hsieh, Jin-Bin Wu, Ho Lin, Wen-Chuan Lin
BACKGROUND: Anoectochilus formosanus has been used as a Chinese folk medicine and is known as the "King of medicine" in Chinese society due to its versatile pharmacological effects such as anti-hypertension, anti-diabetes, anti-heart disease, anti-lung and liver diseases, anti-nephritis and anti-Rheumatoid arthritis. Kinsenoside is an essential and active compound of A. formosanus (Orchidaceae). However, the anti-arthritic activity of kinsenoside has still not been demonstrated. In the present study, we confirmed that the kinsenoside treatment rheumatoid arthritis induced by collagen-induced arthritis in mice...
2016: BMC Complementary and Alternative Medicine
Sonja Vuč Ković, Katarina Savić Vujović, Dragana Srebro, Branislava Medić, Tatjana Ilic-Mostic
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for the treatment of pain, inflamation and fever. They are usually well tolerated in healthy persons, but in patients with risk factors (advanced age, renal impairment, heart failure, liver disease, concurrent medications with antihypertensive drugs), NSAIDs can induce serious renal adverse effects. They include sodium and water retention with edema, worsening of heart failure, hypertension, hyponatremia, hyperkalemia, acute kidney injury, chronic kidney disease, renal papillary necrosis and acute interstitial nephritis...
2016: Current Medicinal Chemistry
C O Olaiya, A M Esan, T D Alabi
BACKGROUND: Cardiovascular diseases presently rank high as leading causes of death globally. The increasing acceptability of phytomedicine is due to the increasing inefficacy of many modern drugs used for the control of many diseases. The aim of this study was to investigate the ameliorative effects of β-sitosterol (BSS) in comparison with lisinopril, a standard antihypertensive drug, on certain biochemical hypertensive parameters in rats. METHODS: Hypertension was induced with cadmium chloride and biochemical analysis of serum was carried out following treatment with BSS and lisinopril...
September 2014: African Journal of Medicine and Medical Sciences
Celenne Morfin Zepeda, Kristen H Coffey
PATIENT: 66-year-old ethnic Egyptian man. CHIEF COMPLAINT: Hematuria. HISTORY OF PRESENT ILLNESS: The patient had a history of multiple episodes of gross hematuria for the past 5 years. Because the hematuria usually resolved on its own, he did not seek medical attention during that time. Bladder cancer was suspected. PAST MEDICAL HISTORY: The patient had a history of coronary artery disease, hypertension, nephrolithiasis, congestive heart failure, lifelong smoking, and ischemic cardiomyopathy...
2015: Laboratory Medicine
Takao Watanabe, Yoichi Hiasa, Masamoto Torisu, Takayuki Shimizu, Yasunori Yamamoto, Keitaro Kawasaki, Naoyuki Higaki, Hidehiro Murakami, Teru Kumagi, Masanori Abe, Shinya Furukawa, Bunzo Matsuura, Yoshio Ikeda, Hiroaki Tanaka, Teruhito Mochizuki, Morikazu Onji
A 77-year-old man with hypertension, diabetes mellitus, ischemic heart disease and a smoking habit presented at our hospital with sudden abdominal pain. Computed tomography indicated edematous swelling and pneumatosis of the intestinal wall in a localized area of the ascending colon with inflamed adipose tissue. Acute mesenteric ischemia was diagnosed. Abdominal angiography showed stenosis of the mesenteric arteries. Virtual histology-intravascular ultrasound imaging indicated a fibrous change in the superior mesenteric artery with a necrotic core...
August 2011: Clinical Journal of Gastroenterology
Toru Hashimoto, David A Kass
No abstract text is available yet for this article.
June 9, 2015: Proceedings of the National Academy of Sciences of the United States of America
Kjell Tullus
Takaysu arteritis (TA), together with fibromuscular dysplasia, is the most common cause for renovascular hypertension. The diagnosis of vasculitis is important to make as these children benefit from immunosuppressive treatment. In many cases, however, it is more difficult than commonly realised to differentiate between these two diagnoses. Imaging which allows the inflamed arterial wall to be outlined, such as magnetic resonance or positron emission tomography scans, can be very helpful in this context. Revascularisation, either with angioplasty or surgery, seems to be effective and safe, also in children with TA...
August 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Khaleel Al-Obaidy, Fatimah Alruwaii, Areej Al Nemer, Raed Alsulaiman, Zainab Alruwaii, Mohamed A Shawarby
BACKGROUND: Primary gastric actinomycosis is extremely rare, the appendix and ileocecal region being the most commonly involved sites in abdominopelvic actinomycosis. Herein, we report a case of primary gastric actinomycosis. The diagnosis was made on microscopic evaluation of gastroscopic biopsy specimens. To the best of our knowledge, this is the third case to be reported in the literature, in which the diagnosis was made in a gastroscopic biopsy rather than a resection specimen. CASE PRESENTATION: An 87-year-old Saudi male on medication for cardiomyopathy, premature ventricular contractions, renal impairment, hypertension, and dyslipidemia, presented to the emergency department with acute diffuse abdominal pain, abdominal distension, constipation and vomiting for two days, with no history of fever, abdominal surgery or trauma...
2015: BMC Clinical Pathology
Madhuri Kamatham, Adam Wellikoff, Robert Holladay, Gordon Downie
Bronchology/Interventional Procedures Cases ISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Sunday, October 26, 2014 at 10:45 AM - 12:00 PMINTRODUCTION: Fibrosing mediastinitis is an uncommon benign disorder characterised by proliferation of dense fibrous tissue within the mediastinum. We desrcibe a patient with fibrosing mediastinitis presenting with chronic hemoptysis treated with endobronchial spray cryotherapy (SCT)CASE PRESENTATION: A 31 year old african american female with a history of fibrosing mediastinitis presented to an outside hospital with hemoptysis 1-1...
October 1, 2014: Chest
L Orlić, I Mikolasevic, Z Bagic, S Racki, D Stimac, S Milic
Research in recent years has led to the recognition of the importance of nonalcoholic fatty liver disease (NAFLD) and its relationship to the metabolic syndrome (MS). This has led to a growing interest in the potential prognostic value of NAFLD for adverse cardiovascular disease (CVD) outcome. On the other hand, searching for new risk factors for chronic kidney disease (CKD) development and progression is very important. Growing evidence suggests that the MS is an important factor in the pathogenesis of CKD...
2014: Gastroenterology Research and Practice
Antonio C Cordeiro, Bengt Lindholm, Márcio G Sousa, Juliano C Picotti, Gabriel J Nunes, Marcus R O Santana, Waldyr Grimaldi, Fernanda C Amparo, Celso Amodeo, Juan J Carrero
OBJECTIVE: Left ventricular hypertrophy (LVH) is a prevalent condition in chronic kidney disease (CKD) very often underdiagnosed and misdiagnosed. Electrocardiography (ECG) is an easily accessible LVH diagnostic tool. We evaluated the usefulness of commonly applied ECG criteria for LVH diagnosis in CKD patients. METHODS: Cross-sectional evaluation of 253 nondialysis-dependent CKD stages 3-5 patients (61 [53-67] years; 65% men). Left ventricular mass (LVM) was assessed by echocardiography (ECHO)...
February 2014: Journal of Hypertension
Eli Miloslavsky, Sebastian Unizony
All primary vasculitides can target the heart, but this complication is more frequent in TAK, PAN, and EGPA. Although pericarditis is seen in virtually all forms of vasculitis, it rarely becomes a significant clinical problem. Myocarditis is more prevalent in EGPA and TAK, and coronary angiitis is most common in TAK, PAN, and BD. In addition, AI is a classic complication of TAK-induced aortitis, and intracavitary cardiac thrombus formation mainly affects patients with BD. Myocarditis, coronary arteritis, and valvular disease can lead to congestive heart failure and represent poor prognostic factors that require aggressive therapy...
February 2014: Rheumatic Diseases Clinics of North America
Shahin Zandieh, Matthias Schütz, Reinhard Bernt, Jochen Zwerina, Joerg Haller
We report the case of a 50-year-old woman presented with a history of right hemicolectomy due to an ileocecal neuroendocrine tumor and left breast metastasis. Owing to a slightly elevated chromogranin A-level and lower abdominal pain, single photon emission computed tomography-computer tomography (SPECT-CT) was performed. There were no signs of recurrence on the SPECT-CT scan, but the patient was incidentally found to have an inflamed intramural myoma. We believe that the slightly elevated chromogranin A-level was caused by the hypertension that the patient presented...
September 2013: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Patrick H Dessein, Angela J Woodiwiss, Gavin R Norton, Ahmed Solomon
INTRODUCTION: Rheumatoid arthritis (RA) is characterized by inflamed joint-derived cytokine-mediated high-grade systemic inflammation that enhances cardiovascular metabolic risk and disease in developed populations. We investigated the potential impact of RA on cardiovascular risk factors including systemic inflammation and atherosclerosis, and their relationships in black Africans from a developing population. METHODS: We evaluated demographic features, adiposity indices, major traditional cardiovascular risk factors, circulating C-reactive protein and interleukin-6 concentrations and ultrasound determined carotid intima-media thickness (cIMT) in 274 black Africans; 115 had established RA...
2013: Arthritis Research & Therapy
Talya Wolak, Neta Sion-Vardi, Victor Novack, Georg Greenberg, Gabriel Szendro, Tanya Tarnovscki, Ori Nov, Ilan Shelef, Esther Paran, Assaf Rudich
BACKGROUND: Hypertensive patients develop carotid atherosclerotic plaques with enhanced inflammation. Full-length osteopontin (OPN-FL), a multifunctional protein whose levels are elevated in association with atherosclerosis, is cleaved by thrombin and matrix metalloproteinases to form a C-terminal and a putatively biologically active N-terminal fragment (OPN-C, OPN-N, respectively). We conducted a study to examine whether plaque inflammation in hypertensive patients corresponds to the expression of OPN or of its cleaved forms or both...
March 2013: American Journal of Hypertension
Sheikh Fayaz Ahmad, Sarang Bani, Phalisteen Sultan, Sheikh Abid Ali, Saleh A Bakheet, Sabry M Attia, Adel R A Abd-Allah
CONTEXT: Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, and wounds, and it has reported antiallergic, antipyretic, anti-inflammatory activities, etc. OBJECTIVE: This study evaluated the ability of fresh leaves of E. hirta ethanol extract to inhibit the intracellular tumor necrosis factor α (TNF-α) level in the synovial fluid and neutrophils in lipopolysaccharide (LPS)-induced inflamed rat knees...
April 2013: Pharmaceutical Biology
Hagen Boenigk, Frank Meyer, Andreas Koch, Ingo Gastinger
UNLABELLED: Acute appendicitis, one of the most frequent emergencies in general surgery, has been repeatingly investigated with regard to specific aspects such as medical history, clinical symptoms, the perioperative management and follow up. The aim of the study was to investigate relevant and combined determinants for the perioperative management of acute appendicitis a systematic clinical prospective unicenter observational study was conducted. A representative patient cohort was studied (n=9,991; middle Europe) to reflect daily surgical practice through a time period of 27 years divided into 3 separate periods and the frequency of specific categories (e...
October 2012: Polski Przeglad Chirurgiczny
Imtiaz Majid Qazi, Abdul Mohsin Jafar, Khalid Al Abdul Hadi, Zakir Hussain
OBJECTIVES: Acute epiglottitis is a potentially life threatening condition which can lead to fatal airway obstruction in previously healthy individuals. The present study was undertaken to assess the clinical features, management and patient outcomes of epiglottitis in Kuwait over an eight year period. DESIGN: Case series. SETTING: Al Sabah Hospital, Kuwait. METHODS: All patients admitted to the ENT department of Al Sabah hospital between January 2000 and January 2008 with the diagnosis of acute epiglottitis were included in this retrospective study...
December 2009: Indian Journal of Otolaryngology and Head and Neck Surgery
Hiroshi Maeda, Hideaki Nakamura, Jun Fang
The EPR effect results from the extravasation of macromolecules or nanoparticles through tumor blood vessels. We here provide a historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue. In addition, architectural and physiological differences of tumor blood vessels vs that of normal tissue are commented. Furthermore, methods of augmentation of the EPR effect are described, that result in better tumor delivery and improved therapeutic effect, where nitroglycerin, angiotensin I-converting enzyme (ACE) inhibitor, or angiotensin II-induced hypertension are employed...
January 2013: Advanced Drug Delivery Reviews
Charalampos I Liakos, Gregory P Vyssoulis, Andreas P Michaelides, Evangelos I Chatzistamatiou, George Theodosiades, Marina G Toutouza, Maria I Markou, Andreas G Synetos, Ioannis E Kallikazaros, Christodoulos I Stefanadis
Arterial hypertension is an established risk factor for acute coronary syndromes, and physical exertion may trigger the onset of such an event. The mechanisms involved include the rupture of a small, inflamed, coronary plaque and the activation of thrombogenic factors. Blood pressure (BP)-lowering treatment has been associated with beneficial effects on subclinical inflammation and thrombosis at rest and during exercise. This prospective study sought to compare the effect of different antihypertensive drugs on the inflammatory and thrombotic response during exercise...
December 2012: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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