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Aging brain fmri cognition

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https://www.readbyqxmd.com/read/29780309/generation-of-individual-whole-brain-atlases-with-resting-state-fmri-data-using-simultaneous-graph-computation-and-parcellation
#1
J Wang, Z Hao, H Wang
The human brain can be characterized as functional networks. Therefore, it is important to subdivide the brain appropriately in order to construct reliable networks. Resting-state functional connectivity-based parcellation is a commonly used technique to fulfill this goal. Here we propose a novel individual subject-level parcellation approach based on whole-brain resting-state functional magnetic resonance imaging (fMRI) data. We first used a supervoxel method known as simple linear iterative clustering directly on resting-state fMRI time series to generate supervoxels, and then combined similar supervoxels to generate clusters using a clustering method known as graph-without-cut (GWC)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29772378/a-task-invariant-cognitive-reserve-network
#2
Yaakov Stern, Yunglin Gazes, Qolomreza Razlighi, Jason Steffener, Christian Habeck
The concept of cognitive reserve (CR) can explain individual differences in susceptibility to cognitive or functional impairment in the presence of age or disease-related brain changes. Epidemiologic evidence indicates that CR helps maintain performance in the face of pathology across multiple cognitive domains. We therefore tried to identify a single, "task-invariant" CR network that is active during the performance of many disparate tasks. In imaging data acquired from 255 individuals age 20-80 while performing 12 different cognitive tasks, we used an iterative approach to derive a multivariate network that was expressed during the performance of all tasks, and whose degree of expression correlated with IQ, a proxy for CR...
May 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29767302/amyloid-causes-intermittent-network-disruptions-in-cognitively-intact-older-subjects
#3
Susanne G Mueller
Recent findings in AD models but also human patients suggest that amyloid can cause intermittent neuronal hyperactivity. The overall goal of this study was to use dynamic fMRI analysis combined with graph analysis to a) characterize the graph analytical signature of two types of intermittent hyperactivity (spike-like (spike) and hypersynchronus-like (synchron)) in simulated data and b) to attempt to identify one of these signatures in task-free fMRIs of cognitively intact subjects (CN) with or without increased brain amyloid...
May 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29765312/associations-between-daily-mood-states-and-brain-gray-matter-volume-resting-state-functional-connectivity-and-task-based-activity-in-healthy-adults
#4
Elmira Ismaylova, Jessica Di Sante, Jean-Philippe Gouin, Florence B Pomares, Frank Vitaro, Richard E Tremblay, Linda Booij
Numerous studies have shown differences in the functioning in the areas of the frontal-limbic circuitry between depressed patients and controls. However, current knowledge on frontal-limbic neural substrates of individual differences in mood states in everyday life in healthy individuals is scarce. The present study investigates anatomical, resting-state, and functional neural correlates of daily mood states in healthy individuals. We expected to observe associations between mood and the frontal-limbic circuitry and the default-mode network (DMN)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29758374/age-and-alzheimer-s-pathology-disrupt-default-mode-network-functioning-via-alterations-in-white-matter-microstructure-but-not-hyperintensities
#5
Christopher A Brown, Yang Jiang, Charles D Smith, Brian T Gold
The default mode network (DMN) comprises defined brain regions contributing to internally-directed thought processes. Reductions in task-induced deactivation in the DMN have been associated with increasing age and poorer executive task performance, but factors underlying these functional changes remain unclear. We investigated contributions of white matter (WM) microstructure, WM hyperintensities (WMH) and Alzheimer's pathology to age-related alterations in DMN function. Thirty-five cognitively normal older adults and 29 younger adults underwent working memory task fMRI and diffusion tensor imaging...
April 19, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29750977/high-definition-transcranial-direct-current-stimulation-changes-older-adults-subjective-sleep-and-corresponding-resting-state-functional-connectivity
#6
Jing Sheng, Chao Xie, Dong-Qiong Fan, Xu Lei, Jing Yu
With advanced age, older adults show functional deterioration in sleep. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation, modulates individuals' behavioral performance in various cognitive domains. However, the modulation effect and neural mechanisms of tDCS on sleep, especially for the elderly population are not clear. Here, we aimed to investigate whether high-definition transcranial direct current stimulation (HD-tDCS) could modulate community-dwelling older adults' subjective sleep and whether these potential improvements are associated with the large-scale brain activity alterations recorded by functional magnetic resonance imaging...
May 8, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29749715/altered-resting-state-hippocampal-and-caudate-functional-networks-in-patients-with-obstructive-sleep-apnea
#7
Xiaopeng Song, Bhaswati Roy, Daniel W Kang, Ravi S Aysola, Paul M Macey, Mary A Woo, Frisca L Yan-Go, Ronald M Harper, Rajesh Kumar
INTRODUCTION: Brain structural injury and metabolic deficits in the hippocampus and caudate nuclei may contribute to cognitive and emotional deficits found in obstructive sleep apnea (OSA) patients. If such contributions exist, resting-state interactions of these subcortical sites with cortical areas mediating affective symptoms and cognition should be disturbed. Our aim was to examine resting-state functional connectivity (FC) of the hippocampus and caudate to other brain areas in OSA relative to control subjects, and to relate these changes to mood and neuropsychological scores...
May 10, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29745564/-research-progress-about-different-levels-of-cognitive-recession-using-resting-state-functional-connectivity-network-methods
#8
REVIEW
Yanan Liu, Yuanyuan Chen, Miao Sha, Hongzhi Qi, Dong Ming, Peng Zhou
Normal brain aging and a serious of neurodegenerative diseases may lead to decline in memory, attention and executive ability and poorer quality of life. The mechanism of the decline is not clear now and is still a hot issue in the fields of neuroscience and medicine. A large number of researches showed that resting state functional brain networks based functional magnetic resonance imaging (fMRI) are sensitive and susceptive to the change of cognitive function. In this paper, the researches of brain functional connectivity based on resting fMRI in recent years were compared, and the results of subjects with different levels of cognitive decline including normal brain aging, mild cognitive impairment (MCI) and Alzheimer's disease (AD) were reviewed...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744804/frontal-lobe-functioning-during-a-simple-response-conflict-task-in-first-episode-psychosis-and-its-relationship-to-treatment-response
#9
Keith M Shafritz, Toshikazu Ikuta, Allison Greene, Delbert G Robinson, Juan Gallego, Todd Lencz, Pamela DeRosse, Peter B Kingsley, Philip R Szeszko
Prior functional magnetic resonance imaging (fMRI) studies have investigated the neural mechanisms underlying cognitive control in patients with psychosis with findings of both hypo- and hyperfrontality. One factor that may contribute to inconsistent findings is the use of complex and polyfactorial tasks to investigate frontal lobe functioning. In the current study we employed a simple response conflict task during fMRI to examine differences in brain activation between patients experiencing their first-episode of psychosis (n = 33) and age- and sex-matched healthy volunteers (n = 33)...
May 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29742488/from-swing-to-cane-sex-differences-of-eeg-resting-state-temporal-patterns-during-maturation-and-aging
#10
M I Tomescu, T A Rihs, V Rochas, M Hardmeier, J Britz, G Allali, P Fuhr, S Eliez, C M Michel
While many insights on brain development and aging have been gained by studying resting-state networks with fMRI, relating these changes to cognitive functions is limited by the temporal resolution of fMRI. In order to better grasp short-lasting and dynamically changing mental activities, an increasing number of studies utilize EEG to define resting-state networks, thereby often using the concept of EEG microstates. These are brief (around 100 ms) periods of stable scalp potential fields that are influenced by cognitive states and are sensitive to neuropsychiatric diseases...
April 30, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29738855/diminished-neural-network-dynamics-in-amnestic-mild-cognitive-impairment
#11
Einat K Brenner, Frank G Hillary, Emily C Grossner, Rachel A Bernier, Nicholas Gilbert, K Sathian, Benjamin M Hampstead
Mild cognitive impairment (MCI) is widely regarded as an intermediate stage between typical aging and dementia, with nearly 50% of patients with amnestic MCI (aMCI) converting to Alzheimer's dementia (AD) within 30 months of follow-up (Fischer et al., 2007). The growing literature using resting-state functional magnetic resonance imaging reveals both increased and decreased connectivity in individuals with MCI and connectivity loss between the anterior and posterior components of the default mode network (DMN) throughout the course of the disease progression (Hillary et al...
May 5, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29738277/methylphenidate-mediated-motor-control-network-enhancement-in-patients-with-traumatic-brain-injury
#12
Charlie L Dorer, Anne E Manktelow, Judith Allanson, Barbara J Sahakian, John D Pickard, Andrew Bateman, David K Menon, Emmanuel A Stamatakis
PRIMARY OBJECTIVE: To investigate functional improvement late (>6 months) after traumatic brain injury (TBI). To this end, we conducted a double-blind, placebo-controlled experimental medicine study to test the hypothesis that a widely used cognitive enhancer would benefit patients with TBI. RESEARCH DESIGN: We focused on motor control function using a sequential finger opposition fMRI paradigm in both patients and age-matched controls. METHODS AND PROCEDURES: Patients' fMRI and DTI scans were obtained after randomised administration of methylphenidate or placebo...
May 8, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29737186/asymptomatic-hiv-vertical-transmitted-adolescents-brain-functional-changes-based-on-resting-state-functional-mri
#13
Panying Wang, Jielan Li, Xiangyu Wang, Guang-Yao Wu, Deepa Thapa
OBJECTIVE: Perinatal HIV-infected (PHIV+) adolescents survive longer with the use of readily found combination antiretroviral therapy(cART), however, they still have the risk of developing cognitive deficits. The paper aims to explore the brain functional changes in asymptomatic PHIV+ adolescents with cART based on the resting-state functional MRI (rs-fMRI). MATERIALS AND METHODS: rs-fMRI was performed on 20 PHIV+ adolescents and 28 PHIV- controls to evaluate the regional homogeneity (ReHo) in different brain regions by calculating the Kendall harmonious coefficient(KCC)...
May 8, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29720936/the-effects-of-tai-chi-intervention-on-healthy-elderly-by-means-of-neuroimaging-and-eeg-a-systematic-review
#14
Zhujun Pan, Xiwen Su, Qun Fang, Lijuan Hou, Younghan Lee, Chih C Chen, John Lamberth, Mi-Lyang Kim
Aging is a process associated with a decline in cognitive and motor functions, which can be attributed to neurological changes in the brain. Tai Chi, a multimodal mind-body exercise, can be practiced by people across all ages. Previous research identified effects of Tai Chi practice on delaying cognitive and motor degeneration. Benefits in behavioral performance included improved fine and gross motor skills, postural control, muscle strength, and so forth. Neural plasticity remained in the aging brain implies that Tai Chi-associated benefits may not be limited to the behavioral level...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29709628/simultaneous-resting-state-fdg-pet-fmri-in-alzheimer-disease-relationship-between-glucose-metabolism-and-intrinsic-activity
#15
Rocco Marchitelli, Marco Aiello, Arnaud Cachia, Mario Quarantelli, Carlo Cavaliere, Alfredo Postiglione, Gioacchino Tedeschi, Patrizia Montella, Graziella Milan, Marco Salvatore, Elena Salvatore, Jean Claude Baron, Sabina Pappatà
Simultaneously evaluating resting-state brain glucose metabolism and intrinsic functional activity has potential to impact the clinical neurosciences of Alzheimer Disease (AD). Indeed, integrating such combined information obtained in the same physiological setting may clarify how impairments in neuroenergetic and neuronal function interact and contribute to the mechanisms underlying AD. The present study used this multimodality approach to investigate, by means of a hybrid PET/MR scanner, the coupling between glucose consumption and intrinsic functional activity in 23 patients with AD-related cognitive impairment ranging from amnestic mild cognitive impairment (MCI) to mild-moderate AD (aMCI/AD), in comparison with a group of 23 healthy elderly controls...
April 27, 2018: NeuroImage
https://www.readbyqxmd.com/read/29706883/resting-state-functional-connectivity-predicts-cognitive-impairment-related-to-alzheimer-s-disease
#16
Qi Lin, Monica D Rosenberg, Kwangsun Yoo, Tiffany W Hsu, Thomas P O'Connell, Marvin M Chun
Resting-state functional connectivity (rs-FC) is a promising neuromarker for cognitive decline in aging population, based on its ability to reveal functional differences associated with cognitive impairment across individuals, and because rs-fMRI may be less taxing for participants than task-based fMRI or neuropsychological tests. Here, we employ an approach that uses rs-FC to predict the Alzheimer's Disease Assessment Scale (11 items; ADAS11) scores, which measure overall cognitive functioning, in novel individuals...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29692721/a-brainnetome-atlas-based-mild-cognitive-impairment-identification-using-hurst-exponent
#17
Zhuqing Long, Bin Jing, Ru Guo, Bo Li, Feiyi Cui, Tingting Wang, Hongwen Chen
Mild cognitive impairment (MCI), which generally represents the transition state between normal aging and the early changes related to Alzheimer's disease (AD), has drawn increasing attention from neuroscientists due that efficient AD treatments need early initiation ahead of irreversible brain tissue damage. Thus effective MCI identification methods are desperately needed, which may be of great importance for the clinical intervention of AD. In this article, the range scaled analysis, which could effectively detect the temporal complexity of a time series, was utilized to calculate the Hurst exponent (HE) of functional magnetic resonance imaging (fMRI) data at a voxel level from 64 MCI patients and 60 healthy controls (HCs)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29691990/altered-functional-connectivity-strength-and-its-correlations-with-cognitive-function-in-subjects-with-ultra-high-risk-for-psychosis-at-rest
#18
Ran-Ran Li, Hai-Long Lyu, Feng Liu, Nan Lian, Ren-Rong Wu, Jing-Ping Zhao, Wen-Bin Guo
AIMS: Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this study, whole-brain FCS was assessed to examine the altered patterns of FCS in UHR subjects. METHODS: A total of 34 UHR subjects and 37 age- and sex-matched healthy controls were enrolled to undergo resting-state functional magnetic resonance imaging...
April 24, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29680421/mapping-the-changed-hubs-and-corresponding-functional-connectivity-in-idiopathic-restless-legs-syndrome
#19
Chunyan Liu, Jiaojian Wang, Yue Hou, Zhigang Qi, Li Wang, Shuqin Zhan, Rong Wang, Yuping Wang
OBJECTIVE: The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS. METHODS: First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29667272/different-brain-networks-underlying-intelligence-in-autism-spectrum-disorders
#20
Emmanuel Peng Kiat Pua, Charles B Malpas, Stephen C Bowden, Marc L Seal
There has been sustained clinical and cognitive neuroscience research interest in how network correlates of brain-behavior relationships might be altered in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders. As previous work has mostly focused on adults, the nature of whole-brain connectivity networks underlying intelligence in pediatric cohorts with abnormal neurodevelopment requires further investigation. We used network-based statistics (NBS) to examine the association between resting-state functional Magnetic Resonance Imaging (fMRI) connectivity and fluid intelligence ability in male children (n = 50) with Autism Spectrum Disorders (ASD; M = 10...
April 17, 2018: Human Brain Mapping
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