keyword
https://read.qxmd.com/read/37675390/determinants-of-caregiver-s-knowledge-and-practices-regarding-childhood-fever-management-in-a-developing-setting-a-multi-centre-cross-sectional-assessment
#21
JOURNAL ARTICLE
Ibrahim A Ogunyinka, Kazeem A Oshikoya, Kazeem B Yusuff, Yusuf Tahir, Mohammed Yahaya, Sulaiman B Adeniye, Innocent E Oforkansi
INTRODUCTION: Fever is both a sign of various diseases (chief of which are infectious in nature) and an adverse effect of certain interventions (e.g. vaccines, drugs) in the pediatric population. It elicits anxiety among caregivers and healthcare professionals alike resulting in non-evidence based practices, adverse medication administration events, waste of scarce resources and overutilization of health facilities. The determinants of these practices among caregivers in the domiciliary contexts have not been well characterized in developing settings...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37642229/safety-and-immunogenicity-of-co-administered-meningococcal-serogroup-b-4cmenb-vaccine-a-literature-review
#22
REVIEW
Véronique Abitbol, Woo-Yun Sohn, Michael Horn, Marco Aurelio P Safadi
The four-component meningococcal serogroup B vaccine (4CMenB) is indicated for the prevention of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup B. Co-administering 4CMenB with other vaccines may improve vaccine uptake provided that the safety and immunogenicity of either are not affected. Published literature on the immunogenicity and reactogenicity of 4CMenB co-administered with other routine childhood and adulthood vaccines was reviewed. From 282 publications identified, data were collated from 10 clinical studies, 3 real-world studies, and 3 reviews...
August 1, 2023: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/37606145/treatment-of-fever-and-associated-symptoms-in-the-emergency-department-which-drug-to-choose
#23
JOURNAL ARTICLE
F Franceschi, A Saviano, A Carnicelli, C Lorusso, A Novelli, M Candelli, V Ojetti, M Covino
OBJECTIVE: Fever is a frequent cause of admission to the Emergency Department (ED) worldwide. Although it can be caused by a wide range of conditions, the most effective treatment based on its etiology is still undetermined. PATIENTS AND METHODS: This prospective, single-center, observational study enrolled adult patients who accessed the ED for fever. Physicians were free to administer paracetamol 1,000 mg (P), the combination paracetamol 500 mg/ibuprofen 150 mg (PI) or Ibuprofen 600 mg (I)...
August 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37594020/paracetamol-acetaminophen-or-non-steroidal-anti-inflammatory-drugs-alone-or-combined-for-pain-relief-in-acute-otitis-media-in-children
#24
REVIEW
Joline L H de Sévaux, Roger Amj Damoiseaux, Alma C van de Pol, Vittoria Lutje, Alastair D Hay, Paul Little, Anne Gm Schilder, Roderick P Venekamp
BACKGROUND: Acute otitis media (AOM) is one of the most common childhood infectious diseases. Pain is the key symptom of AOM and central to children's and parents' experience of the illness. Because antibiotics provide only marginal benefits, analgesic treatment including paracetamol (acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs) is regarded as the cornerstone of AOM management. This is an update of a review first published in 2016. OBJECTIVES: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM...
August 18, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37524553/parist-study-protocol-a-phase-i-ii-randomised-controlled-clinical-trial-to-assess-the-feasibility-safety-and-effectiveness-of-paracetamol-in-resolving-acute-kidney-injury-in-children-with-severe-malaria
#25
JOURNAL ARTICLE
George Paasi, Charles Benard Okalebo, Paul Ongodia, Cate Namayanja, Egiru Emma Isaiah Eregu, Grace Abongo, Moses Olupot, Denis Amorut, Rita Muhindo, William Okiror, Carolyne Ndila, Peter Olupot-Olupot
BACKGROUND: Acute kidney injury (AKI) has in the past been considered a rare complication of malaria in children living in high-transmission settings. More recently, however, a growing number of paediatric case series of AKI in severe malaria studies in African children have been published (Artesunate vs Quinine in the Treatment of Severe P. falciparum Malaria in African children and Fluids Expansion as Supportive Therapy trials). The Paracetamol for Acute Renal Injury in Severe Malaria Trial (PARIST) therefore, aims to assess feasibility, safety and determine the effective dose of paracetamol, which attenuates nephrotoxicity of haemoproteins, red-cell free haemoglobin and myoglobin in children with haemoglobinuric severe malaria...
July 31, 2023: BMJ Open
https://read.qxmd.com/read/37456396/a-cross-sectional-study-on-self-medication-prevalence-and-usage-patterns-an-alarming-concept-among-the-saudi-population
#26
JOURNAL ARTICLE
Abdul Salam Thekkiniyakath Ali, Abdulrahman Abdulelah A Alsheraihi, Saed Saeed Ibrahim Alghamdi, Rahaf Sulaiman Alsuwaylihi, Suha Sulaiman Alenazi, Lamia Saad Bin Hussain
BACKGROUND: Self-medication (SM) has many potential drawbacks, including toxicity, drug resistance, severe adverse effects, drug interactions, drug abuse, and drug dependence, but it is still widely used for a variety of reasons, including time and money savings, symptom prevention or treatment of minor illnesses, a lack of access to doctors, etc. This study aimed to describe and analyse the usage of antibiotics without a prescription, self-medication practises, and patterns of using them among Saudis...
June 2023: Curēus
https://read.qxmd.com/read/37419227/antipyretic-and-antinociceptive-effects-of-methanolic-extract-of-c-iria-l-tuber
#27
JOURNAL ARTICLE
Roni Roy, Jony Roy, Israt Jahan Liya, Mohammad Anwarul Basher, Muhammad Yusuf Miah
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus iria L. is a sedge belongs to Cyperaceae family. Tuber of this plant is traditionally used in fever. AIM OF THE STUDY: This study aimed to verify the effectiveness of this plant part against fever. Additionally, antinociceptive effect of the plant was evaluated. MATERIALS AND METHODS: Antipyretic effect was evaluated by yeast induced hyperthermia experiment. Antinociceptive effect was determined by acetic acid induced writhing test and hot plate test...
July 5, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37400812/effectiveness-of-saccharomyces-boulardii-cncm-i-745-probiotic-in-acute-inflammatory-viral-diarrhoea-in-adults-results-from-a-single-centre-randomized-trial
#28
JOURNAL ARTICLE
Marcela Ag Salazar-Parra, Roberto U Cruz-Neri, Xóchitl Ar Trujillo-Trujillo, Juan J Dominguez-Mora, Héctor I Cruz-Neri, Jazmín M Guzmán-Díaz, Mario J Guzmán-Ruvalcaba, Jesús O Vega-Gastelum, Kriscia V Ascencio-Díaz, Maria F Zarate-Casas, Fanny Y González-Ponce, Francisco J Barbosa-Camacho, Clotilde Fuentes-Orozco, Gabino Cervantes-Guevara, Enrique Cervantes-Pérez, Guillermo Alonso Cervantes-Cardona, Ana Olivia Cortés-Flores, Alejandro González-Ojeda
BACKGROUND: Probiotics are effective for treating acute infectious diarrhoea caused by bacteria, but there are inconsistent results for the effectiveness of probiotics for diarrhoea caused by viruses. In this article we want to determine whether Sb supplementation has an effect on acute inflammatory viral diarrhoea diagnosed with the multiplex panel PCR test. The aim of this study was to evaluate the efficacy of Saccharomyces boulardii (Sb) as a treatment in patients diagnosed with viral acute diarrhoea...
July 3, 2023: BMC Gastroenterology
https://read.qxmd.com/read/37380201/adverse-events-following-immunisation-aefi-of-covishield-vaccination-among-healthcare-workers-in-ghana
#29
JOURNAL ARTICLE
Kissinger Marfoh, Ali Samba, Eunice Okyere, Frankline Acheampong, Elsie Owusu, Dorothy Naa Ashokor Darko, Joseph Zakariah, Hillary Mensa, Ernestina Aidoo, Yasmin Mohammed
OBJECTIVE: To describe the incidence of adverse events following immunisation (AEFI) and determine the factors that affect the onset and duration of AEFI after COVISHIELD vaccination among healthcare workers. DESIGN: Prospective cohort study. SETTING: Tertiary healthcare, Korle-Bu, Ghana. PARTICIPANT: Three thousand and twenty-two healthcare workers at least 18 years of age were followed up for 2 months after receiving two doses of the COVISHIELD vaccine...
June 28, 2023: BMJ Open
https://read.qxmd.com/read/37375915/cinnamon-oil-alleviates-acetaminophen-induced-uterine-toxicity-in-rats-by-abrogation-of-oxidative-stress-apoptosis-and-inflammation
#30
JOURNAL ARTICLE
Sohail Hussain, Saeed Alshahrani, Rahimullah Siddiqui, Andleeb Khan, Manal Mohammed Elhassan Taha, Rayan A Ahmed, Abdulmajeed M Jali, Marwa Qadri, Khairat H M Khairat, Mohammad Ashafaq
Paracetamol, or acetaminophen (APAP), is one of the first-line medications that is used for fever and pain. However, APAP can induce uterine toxicity when overused. The mode of action of APAP toxicity is due to the production of free radicals. The main goal of our study is to determine uterine toxicity from APAP overdose and the antioxidative activity of cinnamon oil (CO) in female rats. The effect of different doses of CO (50-200 mg/kg b.w.) was assessed in the uterus toxicity induced by APAP. Additionally, the imbalance in oxidative parameters, interleukins, and caspases was evaluated for the protective effects of CO...
June 12, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37312532/role-of-n-acetylcysteine-in-liver-injury-due-to-dengue-fever
#31
REVIEW
Monica Gupta, Samiksha Gupta, Dhriti Sood, Akanksha Gupta, Gautam Jesrani
Dengue fever (DF) is a common mosquito-borne viral infection which is endemic in Southeast Asia. Liver involvement may vary from asymptomatic elevation of liver enzymes to fulminant hepatitis. Although the valuable effects of N-acetylcysteine (NAC) in paracetamol toxicity and non-paracetamol liver failure have been extensively studied, its use in DF-associated hepatitis remains unclear. We made a literature search in an online format from libraries such as PubMed, Google Scholar, and EMBASE, and selected 33 articles including original research articles, case reports, and systemic analyses...
June 13, 2023: Tropical Doctor
https://read.qxmd.com/read/37223830/exploration-of-dft-and-td-dft-computation-to-investigate-the-interaction-between-paracetamol-and-lithium-or-its-compounds
#32
JOURNAL ARTICLE
Madhur Babu Singh, Pooja Bhagat, Pallavi Jain, Prashant Singh
Paracetamol is a commonly used antipyretic drug and its consumption drastically was increased during the COVID-19 times as fever was one of the symptoms. The excessive usage of paracetamol could harm humans, as the unused accumulated paracetamol can involve in the reaction with many small molecules as well as can interact with several biomolecules. Lithium chloride in its hydrated form is used as an antimanic drug and a geroprotector. It is needed in very small quantities by humans. Tetrahydrated form of lithium ion is the most stable hydrated form...
August 1, 2023: Journal of Molecular Liquids
https://read.qxmd.com/read/37151075/paracetamol-acetaminophen-associated-sjs-ten-agep-and-dress-syndromes-a-narrative-review
#33
JOURNAL ARTICLE
Naina Mohamed Pakkir Maideen, Ibrahim Ramadan Barakat, AbduRazak Hassan Jumale
INTRODUCTION: Paracetamol (Acetaminophen) is a very common OTC drug that is found in more than 200 OTC products sold as pain, cough and cold remedies. Paracetamol is commonly used as an antipyretic to reduce fever and as an alternative to Non-steroidal anti-inflammatory drugs (NSAIDs) that are contraindicated in certain patients to relieve mild-moderate pain. OBJECTIVE: This review article focuses on SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes associated with the use of paracetamol or paracetamol-containing products...
May 5, 2023: Current Drug Safety
https://read.qxmd.com/read/37076467/a-case-report-of-cefixime-paracetamol-and-nimesulide-induced-toxic-epidermal-necrolysis-in-a-woman-with-dengue-infection-without-any-other-associated-comorbidities
#34
Renuka Munshi, Miteshkumar Maurya
BACKGROUND: Toxic Epidermal Necrolysis (TEN) is a rare, acute, and life-threatening mucocutaneous disease that occurs after the administration of certain drugs, resulting in extensive keratinocyte cell death, skin involvement at the dermal-epidermal junction, and extensive bullous skin eruptions and sloughing. Many published case reports have observed the presence of fever with a viral infection, drug, and/or genetic association as a possible trigger for TEN but associated with other comorbidities...
April 18, 2023: Current Drug Safety
https://read.qxmd.com/read/36969272/discomfort-relief-after-paracetamol-administration-in-febrile-children-admitted-to-a-third-level-paediatric-emergency-department
#35
JOURNAL ARTICLE
Elena Chiappini, Matilde Bestetti, Stefano Masi, Teresa Paba, Elisabetta Venturini, Luisa Galli
BACKGROUND: international guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children. METHODS: Between 1st January and 30th September 2021 a single-center prospective observational study was performed in febrile children consecutively admitted to a pediatric emergency department and treated with paracetamol orally...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/36964758/supratherapeutic-utilization-of-paracetamol-versus-ibuprofen-among-12-year-old-children-in-primary-care-in-istanbul
#36
JOURNAL ARTICLE
Dilara Bayram, Caner Vizdiklar, Volkan Aydin, Narin Akici, Omer Atac, Ahmet Akici
BACKGROUND: Paracetamol and ibuprofen are the most preferred analgesics for pain and fever management in children. Prescribing of these drugs in supratherapeutic doses may predispose to their toxicity. We aimed to compare prescribing patterns and potential overdosing of paracetamol and ibuprofen in primary care for <12-year-old children. METHODS: We analysed paracetamol- and ibuprofen-containing prescriptions (PCPs, n = 173,575 and ICPs, n = 145,655) of 1- to 11-year-old children, issued by 3:1 systematically sampled primary care physicians (n = 1,431) in Istanbul during 2016...
March 25, 2023: Family Practice
https://read.qxmd.com/read/36941046/paracetamol-use-in-pregnancy-not-as-safe-as-we-may-think
#37
JOURNAL ARTICLE
Katinka Nilsen, Anne Cathrine Staff, Stine Kleppe Krogsrud
Paracetamol is used by more than 50% of women worldwide during pregnancy; headache representing the most frequent indication. Several studies report that long-term exposure to paracetamol in utero is associated with adverse neurodevelopmental outcomes in children, indicating a dose-response effect. However, less or no risk is found to be associated with short-term exposure. Paracetamol most likely crosses the placenta through passive diffusion, and there are several possible mechanisms for how paracetamol might affect fetal brain development...
June 2023: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/36928608/common-selfcare-indications-of-pain-medications-in-children
#38
REVIEW
William Zempsky, John Bell, Vanessa Maria Mossali, Preeti Kachroo, Kamran Siddiqui
Pain has a multifaceted impact on individuals worldwide, affecting their physical functioning, emotional well-being, and quality of life. Children (age < 18 years) have a high prevalence of conditions associated with pain, such as toothache, headache, earache, sore throat, and respiratory tract infections, many of which may be accompanied by fever. Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects...
May 2023: Paediatric Drugs
https://read.qxmd.com/read/36901514/over-the-counter-pain-medications-used-by-adults-a-need-for-pharmacist-intervention
#39
JOURNAL ARTICLE
Katarzyna Karłowicz-Bodalska, Natalia Sauer, Laura Jonderko, Anna Wiela-Hojeńska
The safety of pharmacotherapy for geriatric patients is an essential aspect of the demographic perspective in view of the increasing size of this population. Non-opioid analgesics (NOAs) are among the most popular and often overused over-the-counter medications (OTC). The reasons for drug abuse are common in the geriatric population: musculoskeletal disorders, colds, inflammation and pain of various origins. The popularity of self-medication and the ability to easily access OTC drugs outside the pharmacy creates the danger of their misuse and the incidence of adverse drug reactions (ADRs)...
March 3, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36843677/evaluation-of-the-performance-of-anganwadi-workers-in-delivering-integrated-child-development-services-in-the-rural-field-practice-area-of-a-tertiary-medical-college-in-south-india
#40
JOURNAL ARTICLE
Ipsita Debata, T S Ranganath
Background and objective To meet the overall developmental needs of children below six years, adolescent girls, and expectant and nursing mothers, the Integrated Child Development Services (ICDS) was launched on 2nd October 1975 via the network of Anganwadis. It included a range of services like supplementary nutrition, preschool education, immunization, health check-up, referral services, and nutrition and health education. The majority of Karnataka's population resides in rural areas (61.3%) and among them, children (aged zero to six years) constitute around 12...
January 2023: Curēus
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