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paracetamol in fever

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https://www.readbyqxmd.com/read/28078650/in-vivo-efficacy-of-latex-from-calotropis-procera-in-ameliorating-fever-biochemical-characteristics-and-plausible-mechanism
#1
Vijay L Kumar, B Guruprasad, Syed Meraj A Fatmi, Priyanka Chaudhary, Nylane Maria Nunes Alencar, José Vitor Moreira Lima-Filho, Márcio Viana Ramos
Calotropis procera latex fractions possessing anti-inflammatory property were characterized for their biochemical properties, compared for their efficacy in ameliorating fever in rats and their mechanism of action was elucidated. Aqueous fraction and methanol extract (AqDL and MeDL) were derived from the dried latex (DL) and proteins were separated from the fresh latex (LP). Polyacrylamide gel electrophoresis carried out under denaturing conditions showed the presence of proteins with some similarity in LP and AqDL and both of these fractions exhibited proteinase activity by gelatin zymography...
January 11, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28063133/a-clinical-and-safety-review-of-paracetamol-and-ibuprofen-in-children
#2
REVIEW
Dipak J Kanabar
The antipyretic analgesics, paracetamol, and non-steroidal anti-inflammatory agents NSAIDs are one of the most widely used classes of medications in children. The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age.
January 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28031314/paracetamol-use-during-pregnancy-and-attention-and-executive-function-in-offspring-at-age-5-years
#3
Zeyan Liew, Cathrine Carlsen Bach, Robert F Asarnow, Beate Ritz, Jørn Olsen
BACKGROUND: Recent studies suggested that inutero exposure to paracetamol, the most common pain and fever medication used in pregnancy, may affect neurodevelopment in offspring. We aim to examine whether maternal use of paracetamol during pregnancy affects the attention and executive function of children at age 5 years. METHODS: We studied 1491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Prenatal paracetamol use was prospectively recorded in three telephone interviews...
December 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27992852/paracetamol-in-fever-in-critically-ill-patients-an-update
#4
REVIEW
D Chiumello, M Gotti, G Vergani
Fever, which is arbitrary defined as an increase in body temperature above 38.3°C, can affect up to 90% of patients admitted in intensive care unit. Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons). Fever is associated with increased length of stay in intensive care unit and with a worse outcome in some subgroups of patients (mainly neurocritically ill patients). Although fever can increase oxygen consumption in unstable patients, on the contrary, it can activate physiologic systems that are involved in pathogens clearance...
November 5, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27977844/paracetamol-acetaminophen-or-non-steroidal-anti-inflammatory-drugs-alone-or-combined-for-pain-relief-in-acute-otitis-media-in-children
#5
REVIEW
Alies Sjoukes, Roderick P Venekamp, Alma C van de Pol, Alastair D Hay, Paul Little, Anne Gm Schilder, Roger Amj Damoiseaux
BACKGROUND: Acute otitis media (AOM) is one of the most common childhood infectious diseases and a significant reason for antibiotic prescriptions in children worldwide. Pain from middle ear infection and pressure behind the eardrum is the key symptom of AOM. Ear pain is central to children's and parents' experience of the illness. Because antibiotics provide only marginal benefits, analgesic treatment including paracetamol (acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs) is regarded as the cornerstone of AOM management in children...
15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27958254/parental-beliefs-and-practices-regarding-childhood-fever-in-turkish-primary-care
#6
E Yavuz, E Yayla, S E Cebeci, E Kırımlı, R Ş Gümüştakım, L Çakır, S Doğan
BACKGROUND: Fever is a very common problem in pediatric age and is one of the most common reasons parents seek medical attention. We aimed to investigate beliefs, habits, and concerns of Turkish parents regarding their children's fever. MATERIALS AND METHODS: We performed a cross-sectional survey which was conducted as face-to-face interviews by family physicians from April to June 2014 in family healthcare centers in nine different cities in Turkey. Parents with a child with fever aged between 0 and 14 years were interviewed...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27927089/an-evaluation-of-the-anti-inflammatory-antipyretic-and-analgesic-effects-of-hydroethanol-leaf-extract-of-albizia-zygia-in-animal-models
#7
Wonder Kofi Mensah Abotsi, Stanley Benjamin Lamptey, Stephen Afrane, Eric Boakye-Gyasi, Ruth Uwa Umoh, Eric Woode
CONTEXT: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). OBJECTIVES: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia (AZE) in animal models. MATERIALS AND METHODS: The anti-inflammatory and antipyretic effects of AZE were examined in the carrageenan-induced foot oedema model and the baker's yeast-induced pyrexia test respectively...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27810155/2016-update-of-the-italian-pediatric-society-guidelines-for-management-of-fever-in-children
#8
Elena Chiappini, Elisabetta Venturini, Giulia Remaschi, Nicola Principi, Riccardo Longhi, Pier-Angelo Tovo, Paolo Becherucci, Francesca Bonsignori, Susanna Esposito, Filippo Festini, Luisa Galli, Bice Lucchesi, Alessandro Mugelli, Gian Luigi Marseglia, Maurizio de Martino
OBJECTIVE: To review new scientific evidence to update the Italian guidelines for managing fever in children as drafted by the panel of the Italian Pediatric Society. STUDY DESIGN: Relevant publications in English and Italian were identified through search of MEDLINE and the Cochrane Database of Systematic Reviews from May 2012 to November 2015. RESULTS: Previous recommendations are substantially reaffirmed. Antipyretics should be administered with the purpose to control the child's discomfort...
January 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27792836/randomized-controlled-multicentre-clinical-trial-of-the-antipyretic-effect-of-intravenous-paracetamol-in-patients-admitted-to-hospital-with-infection
#9
Thomas Tsaganos, Ioulia K Tseti, Nikolaos Tziolos, Georgios-Stefanos Soumelas, Marina Koupetori, Athina Pyrpasopoulou, Karolina Akinosoglou, Charalambos Gogos, Nikolaos Tsokos, Asterios Karagiannis, Styliani Sympardi, Evangelos J Giamarellos-Bourboulis
AIM: No randomized study has been conducted to investigate the use of intravenous paracetamol (acetaminophen, APAP) for the management of fever due to infection. The present study evaluated a new ready-made infusion of paracetamol. METHODS: Eighty patients with a body temperature onset ≥38.5°C in the previous 24 h due to infection were randomized to a single administration of placebo (n = 39) or 1 g paracetamol (n = 41), and their temperature was recorded at standard intervals...
October 28, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27781110/why-fever-phobia-is-still-common
#10
Suzan Gunduz, Esma Usak, Tulin Koksal, Metin Canbal
BACKGROUND: Fever is a reliable sign of illness, but it also evokes fear and anxiety. It is not the fever itself but the fear of possible complications and accompanying symptoms that is important for pediatricians and parents. OBJECTIVES: We aimed to investigate maternal understanding of fever, its potential consequences, and impacts on the treatment of children. PATIENTS AND METHODS: A questionnaire was use to explore the attitudes, knowledge, and practices of mothers of 861 children brought to four medical centers in different regions of Turkey in 2012, with fever being the chief complaint...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27733747/national-modulators-of-symptomatic-fever-management-in-children-comparative-analysis-of-survey-data
#11
Sebastiano A Lava, Maristella Santi, Gregorio P Milani, Mario G Bianchetti, Giacomo D Simonetti
BACKGROUND: In symptomatic fever management of children, cultural differences have been detected. We aimed at investigating the presence of national modulators of symptomatic fever management. METHODS: We analyzed the data collected in the context of the Swiss national survey on symptomatic fever management in children and of an adapted version of that survey performed in Lombardy (Northern Italy). RESULTS: Ibuprofen (p<0.001) and an alternation regimen with 2 drugs (p<0...
October 12, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27567587/effects-of-luteolin-and-quercetin-3-%C3%AE-d-glucoside-identified-from-passiflora-subpeltata-leaves-against-acetaminophen-induced-hepatotoxicity-in-rats
#12
Saravanan Shanmugam, Parimelazhagan Thangaraj, Bruno Dos Santos Lima, Rahul Chandran, Adriano Antunes de Souza Araújo, Narendra Narain, Mairim Russo Serafini, Lucindo José Quintans Júnior
Passiflora subpeltata has many beneficial effects in the treatment of various diseases including inflammation, pain and fever. This study was aimed to analyze the phytochemical compounds present in acetone extract of P. subpeltata leaves and to evaluate their performance against paracetamol induced hepatotoxicity activity. HPLC-DAD method was used to identify and quantify the phytochemical compounds. Hepatoprotective activity of acetone extract in the treatment of rat liver functions was monitored by the measurement of blood parameters and serum biochemical parameters such as SGOT, SGPT, ALP and in vivo antioxidant parameters viz...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27541270/effects-of-prophylactic-ibuprofen-and-paracetamol-administration-on-the-immunogenicity-and-reactogenicity-of-the-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugated-vaccine-phid-cv-co-administered-with-dtpa-combined-vaccines-in-children
#13
Oana Falup-Pecurariu, Sorin C Man, Mihai L Neamtu, Gratiana Chicin, Ginel Baciu, Carmen Pitic, Alexandra C Cara, Andrea E Neculau, Marin Burlea, Ileana L Brinza, Cristina N Schnell, Valentina Sas, Valeriu V Lupu, Nancy François, Kristien Swinnen, Dorota Borys
Prophylactic paracetamol administration impacts vaccine immune response; this study ( www.clinicaltrials.gov : NCT01235949) is the first to assess PHiD-CV immunogenicity following prophylactic ibuprofen administration. In this phase IV, multicenter, open-label, randomized, controlled, non-inferiority study in Romania (November 2010-December 2012), healthy infants were randomized 3:3:3:1:1:1 to prophylactically receive immediate, delayed or no ibuprofen (IIBU, DIBU, NIBU) or paracetamol (IPARA, DPARA, NPARA) after each of three primary doses (PHiD-CV at age three/four/five months co-administered with DTPa-HBV-IPV/Hib at three/five and DTPa-IPV/Hib at four months) or booster dose (PHiD-CV and DTPa-HBV-IPV/Hib; 12-15 months)...
August 19, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27479646/prenatal-use-of-acetaminophen-and-child-iq-a-danish-cohort-study
#14
Zeyan Liew, Beate Ritz, Jasveer Virk, Onyebuchi A Arah, Jørn Olsen
BACKGROUND: Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy, and recently has been linked to hyperactivity and behavioral problems in children. We examine whether prenatal use of acetaminophen affects children's intelligence quotient (IQ). METHODS: We studied 1,491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Acetaminophen use in pregnancy was prospectively recorded in three telephone interviews...
November 2016: Epidemiology
https://www.readbyqxmd.com/read/27476283/effect-of-paracetamol-on-melanization-process-in-human-epidermal-melanocytes
#15
Dorota Wrześniok, Martyna Oprzondek, Anna Hechmann, Artur Beberok, Michał Otreba, Ewa Buszman
Paracetamol (acetaminophen) is commonly used as a drug of choice for treatment of pain and fever. Unlike non-steroidal anti-inflammatory drugs (NSAIDs) it does not cause gastrointestinal damage or untoward cardiorenal effects, however cutaneous adverse effects have been reported. It is known that paracetamol binds to melanin biopolymers, but the relation between the affinity of this drug to melanin and its toxicity is not documented. The aim of this work was to examine the impact of paracetamol on melanogenesis in cultured human normal epidermal melanocytes (HEMn-DP)...
May 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/27458336/genetic-syndromes-maternal-diseases-and-antenatal-factors-associated-with-autism-spectrum-disorders-asd
#16
REVIEW
Asher Ornoy, Liza Weinstein-Fudim, Zivanit Ergaz
Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Among the genetic disorders we find Fragile X, Rett syndrome, tuberous sclerosis, Timothy syndrome, Phelan-McDermid syndrome, Hamartoma tumor syndrome, Prader-Willi and Angelman syndromes, and a few others...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27458064/ibuprofen-in-paediatrics-pharmacology-prescribing-and-controversies
#17
Camilla Moriarty, Will Carroll
Ibuprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory drug. The oral formulation is widely used in paediatric practice and after paracetamol it is one of the most common drugs prescribed for children in hospital. The treatment of fever with antipyretics such as ibuprofen is controversial as fever is the normal response of the body to infection and unless the child becomes distressed or symptomatic, fever alone should not be routinely treated. Combined treatment with paracetamol and ibuprofen is commonly undertaken but almost certainly is not helpful...
December 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27393615/childhood-fever-in-well-child-clinics-a-focus-group-study-among-doctors-and-nurses
#18
Kirsten K B Peetoom, Luc J L Ploum, Jacqueline J M Smits, Nicky S J Halbach, Geert-Jan Dinant, Jochen W L Cals
BACKGROUND: Fever is common in children aged 0-4 years old and often leads to parental worries and in turn, high use of healthcare services. Educating parents may have beneficial effects on their sense of coping and fever management. Most parents receive information when their child is ill but it might be more desirable to educate parents in the setting of well-child clinics prior to their child becoming ill, in order to prepare parents for future illness management. This study aims to explore experiences of well-child clinic professionals when dealing with childhood fever and current practices of fever information provision to identify starting points for future interventions...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27372871/anthropogenic-and-temporal-components-in-a-complex-trigger-of-type-1-diabetes-suggest-the-active-participation-of-antipyretics
#19
Darijus Veteikis
Tremendous efforts in research without a conclusion on the cause of type 1 diabetes allow the presumption that there is still a blind spot in the development of T1D that is not covered by current hypotheses. The review of geographical knowledge suggests that there is a well-expressed anthropogenic element within the complex environmental trigger of T1D. On the other hand, the initiation of T1D's directed autoimmunity is temporally related to the organism's immune response, induced by entero-viruses, most expectedly...
August 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27369652/paracetamol-induced-fixed-drug-eruption-in-a-patient-with-recurrent-fever-and-rash
#20
Emine Dibek Mısırlıoğlu, Alkım Öden Akman, Emine Vezir, Özge Başaran, Nilgün Çakar, Can Naci Kocabaş
No abstract text is available yet for this article.
August 2016: Annals of Allergy, Asthma & Immunology
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