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paracetamol in fever

Sebastiano A Lava, Maristella Santi, Gregorio P Milani, Mario G Bianchetti, Giacomo D Simonetti
BACKGROUND: In symptomatic fever management of children, cultural differences have been detected. We aimed at investigating the presence of national modulators of symptomatic fever management. METHODS: We analyzed the data collected in the context of the Swiss national survey on symptomatic fever management in children and of an adapted version of that survey performed in Lombardy (Northern Italy). RESULTS: Ibuprofen (p<0.001) and an alternation regimen with 2 drugs (p<0...
October 12, 2016: Minerva Pediatrica
Saravanan Shanmugam, Parimelazhagan Thangaraj, Bruno Dos Santos Lima, Rahul Chandran, Adriano Antunes de Souza Araújo, Narendra Narain, Mairim Russo Serafini, Lucindo José Quintans Júnior
Passiflora subpeltata has many beneficial effects in the treatment of various diseases including inflammation, pain and fever. This study was aimed to analyze the phytochemical compounds present in acetone extract of P. subpeltata leaves and to evaluate their performance against paracetamol induced hepatotoxicity activity. HPLC-DAD method was used to identify and quantify the phytochemical compounds. Hepatoprotective activity of acetone extract in the treatment of rat liver functions was monitored by the measurement of blood parameters and serum biochemical parameters such as SGOT, SGPT, ALP and in vivo antioxidant parameters viz...
August 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Oana Falup-Pecurariu, Sorin C Man, Mihai L Neamtu, Gratiana Chicin, Ginel Baciu, Carmen Pitic, Alexandra C Cara, Andrea E Neculau, Marin Burlea, Ileana L Brinza, Cristina N Schnell, Valentina Sas, Valeriu V Lupu, Nancy François, Kristien Swinnen, Dorota Borys
Prophylactic paracetamol administration impacts vaccine immune response; this study ( : NCT01235949) is the first to assess PHiD-CV immunogenicity following prophylactic ibuprofen administration. In this phase IV, multicenter, open-label, randomized, controlled, non-inferiority study in Romania (November 2010-December 2012), healthy infants were randomized 3:3:3:1:1:1 to prophylactically receive immediate, delayed or no ibuprofen (IIBU, DIBU, NIBU) or paracetamol (IPARA, DPARA, NPARA) after each of three primary doses (PHiD-CV at age three/four/five months co-administered with DTPa-HBV-IPV/Hib at three/five and DTPa-IPV/Hib at four months) or booster dose (PHiD-CV and DTPa-HBV-IPV/Hib; 12-15 months)...
August 19, 2016: Human Vaccines & Immunotherapeutics
Zeyan Liew, Beate Ritz, Jasveer Virk, Onyebuchi A Arah, Jørn Olsen
BACKGROUND: Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy, and recently has been linked to hyperactivity and behavioral problems in children. We examine whether prenatal use of acetaminophen affects children's intelligence quotient (IQ). METHODS: We studied 1,491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Acetaminophen use in pregnancy was prospectively recorded in three telephone interviews...
November 2016: Epidemiology
Dorota Wrześniok, Martyna Oprzondek, Anna Hechmann, Artur Beberok, Michał Otreba, Ewa Buszman
Paracetamol (acetaminophen) is commonly used as a drug of choice for treatment of pain and fever. Unlike non-steroidal anti-inflammatory drugs (NSAIDs) it does not cause gastrointestinal damage or untoward cardiorenal effects, however cutaneous adverse effects have been reported. It is known that paracetamol binds to melanin biopolymers, but the relation between the affinity of this drug to melanin and its toxicity is not documented. The aim of this work was to examine the impact of paracetamol on melanogenesis in cultured human normal epidermal melanocytes (HEMn-DP)...
May 2016: Acta Poloniae Pharmaceutica
Asher Ornoy, Liza Weinstein-Fudim, Zivanit Ergaz
Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Among the genetic disorders we find Fragile X, Rett syndrome, tuberous sclerosis, Timothy syndrome, Phelan-McDermid syndrome, Hamartoma tumor syndrome, Prader-Willi and Angelman syndromes, and a few others...
2016: Frontiers in Neuroscience
Camilla Moriarty, Will Carroll
Ibuprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory drug. The oral formulation is widely used in paediatric practice and after paracetamol it is one of the most common drugs prescribed for children in hospital. The treatment of fever with antipyretics such as ibuprofen is controversial as fever is the normal response of the body to infection and unless the child becomes distressed or symptomatic, fever alone should not be routinely treated. Combined treatment with paracetamol and ibuprofen is commonly undertaken but almost certainly is not helpful...
July 25, 2016: Archives of Disease in Childhood. Education and Practice Edition
Kirsten K B Peetoom, Luc J L Ploum, Jacqueline J M Smits, Nicky S J Halbach, Geert-Jan Dinant, Jochen W L Cals
BACKGROUND: Fever is common in children aged 0-4 years old and often leads to parental worries and in turn, high use of healthcare services. Educating parents may have beneficial effects on their sense of coping and fever management. Most parents receive information when their child is ill but it might be more desirable to educate parents in the setting of well-child clinics prior to their child becoming ill, in order to prepare parents for future illness management. This study aims to explore experiences of well-child clinic professionals when dealing with childhood fever and current practices of fever information provision to identify starting points for future interventions...
2016: BMC Health Services Research
Darijus Veteikis
Tremendous efforts in research without a conclusion on the cause of type 1 diabetes allow the presumption that there is still a blind spot in the development of T1D that is not covered by current hypotheses. The review of geographical knowledge suggests that there is a well-expressed anthropogenic element within the complex environmental trigger of T1D. On the other hand, the initiation of T1D's directed autoimmunity is temporally related to the organism's immune response, induced by entero-viruses, most expectedly...
August 2016: Medical Hypotheses
Emine Dibek Mısırlıoğlu, Alkım Öden Akman, Emine Vezir, Özge Başaran, Nilgün Çakar, Can Naci Kocabaş
No abstract text is available yet for this article.
August 2016: Annals of Allergy, Asthma & Immunology
Aziz-un-Nisa Abbasi
Zika virus (ZIKV) is an arbovirus belonging to flaviviridae family that includes Dengue, West Nile, and Yellow Fever among others. Zika virus was first discovered in 1947 in Zika forest of Uganda. It is a vector borne disease, which has been sporadically reported mostly from Africa, Pacific islands and Southeast Asia since its discovery. ZIKV infection presents as a mild illness with symptoms lasting for several days to a week after the bite of an infected mosquito. Majority of the patients have low grade fever, rash, headaches, joints pain, myalgia, and flu like symptoms...
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
Caroline Saint-Martin, Lukshe Kanagaratnam, Paul de Boissieu, Brahim Azzouz, Malak Abou Taam, Thierry Trenque
AIM: To describe the adverse drug reactions (ADR) and the drugs involved in pediatrics. METHODS: An observational study on all ADR notifications recorded in the French pharmacovigilance database by the Regional Pharmacovigilance Center of Champagne-Ardenne between 1 January 1985 and 31 December 2014 involving children from 0 to 17 years inclusive was performed. For all notifications, we studied the patient and the ADR characteristics. RESULTS: During the study period, 632 notifications were collected...
April 11, 2016: Thérapie
June-Il Bae, Shin Ahn, Yoon-Seon Lee, Won Young Kim, Jae Ho Lee, Bum Jin Oh, Kyung Soo Lim
Propacetamol, a water-soluble prodrug form of paracetamol, is hydrolyzed by esterase to generate paracetamol in the blood. Each gram of propacetamol is equal to 0.5 g of paracetamol. It has been reported to cause hypotension in critically ill patients with a fever. We aimed to investigate the hemodynamic effects of propacetamol for the control of fever in patients with diverse severities of illness who were managed in the emergency department (ED). We also aimed to identify clinical factors related to significant hemodynamic alterations in ED patients...
May 10, 2016: Internal and Emergency Medicine
Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J White, Arjen M Dondorp, Joel Tarning
BACKGROUND: Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patients may not be able to take the oral drug reliably. A comparison between the pharmacokinetics of oral syrup and intramuscular paracetamol given to patients with acute falciparum malaria and high body temperature was performed. METHODS: A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted...
2016: Malaria Journal
Kennedy Obebi Cliff-Eribo, Helen Sammons, Kristina Star, I Ralph Edwards, Adeline Osakwe, Imti Choonara
BACKGROUND: Adverse drug reactions (ADRs) in children recorded in national pharmacovigilance databases in high-income countries have been analysed. Nigeria has a population of 31 million children and became a member of the WHO Programme for International Drug Monitoring in 2004 since when it has been submitting reports of suspected ADRs to the WHO Global Individual Case Safety Report database, VigiBase. OBJECTIVE: To gain information on reported ADRs in Nigerian children aged 0-17 years in VigiBase from 2005 to 2012...
January 29, 2016: Paediatrics and International Child Health
Chittaranjan Andrade
Prenatal exposure to acetaminophen may result in compromised neurodevelopment through inflammatory and immunologic mechanisms, through predisposition to oxidative stress, and through endocrine, endogenous cannabinoid, and other mechanisms. Several small and large prospective studies have found an association between gestational acetaminophen exposure and attention-deficit/hyperactivity disorder (ADHD)-like behaviors, use of ADHD medication, and ADHD diagnoses in offspring during childhood; the only negative study was a small investigation that examined only one aspect of attention as an outcome...
March 2016: Journal of Clinical Psychiatry
Márcia G Alves Galvão, Marilene Augusta Rocha Crispino Santos, Antonio J L Alves da Cunha
BACKGROUND: Undifferentiated acute respiratory infections (ARIs) are a large and heterogeneous group of infections not clearly restricted to one specific part of the upper respiratory tract, which last for up to seven days. They are more common in pre-school children in low-income countries and are responsible for 75% of the total amount of prescribed antibiotics in high-income countries. One possible rationale for prescribing antibiotics is the wish to prevent bacterial complications...
2016: Cochrane Database of Systematic Reviews
Mohammad Reza Sharif, Mostafa Haji Rezaei, Marzieh Aalinezhad, Golbahareh Sarami, Masoud Rangraz
BACKGROUND: Fever is the most common complaint in pediatric medicine and its treatment is recommended in some situations. Paracetamol is the most common antipyretic drug, which has serious side effects such as toxicity along with its positive effects. Diclofenac is one of the strongest non-steroidal anti-inflammatory (NSAID) drugs, which has received little attention as an antipyretic drug. OBJECTIVES: This study was designed to compare the antipyretic effectiveness of the rectal form of Paracetamol and Diclofenac...
January 2016: Iranian Red Crescent Medical Journal
Maria C Magnus, Øystein Karlstad, Siri E Håberg, Per Nafstad, George Davey Smith, Wenche Nystad
BACKGROUND: Paracetamol exposure has been positively associated with asthma development. The relative importance of prenatal vs infant exposure and confounding by indication remains elusive. We examined the association of prenatal and infant (first 6 months) paracetamol exposure with asthma development while addressing confounding by indication. METHODS: We used information from the Norwegian Mother and Child Cohort Study, including 53169 children for evaluation of current asthma at 3 years, 25394 for current asthma at 7 years and 45607 for dispensed asthma medications at 7 years in the Norwegian Prescription Database...
April 2016: International Journal of Epidemiology
Félix Djossou, Guillaume Vesin, Gaelle Walter, Loïc Epelboin, Emilie Mosnier, Bastien Bidaud, Philippe Abboud, Antoine Okandze, Severine Mattheus, Narcisse Elenga, Magalie Demar, Denis Malvy, Mathieu Nacher
BACKGROUND: The objective of the study was to determine the incidence of transaminase elevation during dengue, and its predictive factors. METHODS: In 2013, a longitudinal study was performed using data from all cases of dengue seen in Cayenne Hospital. Cox proportional modeling was used. Signs of major transaminase elevation were defined as an increase in aspartate amino transferase (AST) or alanine amino transferase (ALT) concentration over 10 times the normal value (10N)...
February 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
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