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paracetamol in fever

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https://www.readbyqxmd.com/read/29738273/the-antipyretic-effect-of-paracetamol-occurs-independent-of-transient-receptor-potential-ankyrin-1-mediated-hypothermia-and-is-associated-with-prostaglandin-inhibition-in-the-brain
#1
Elahe Mirrasekhian, Johan L Å Nilsson, Kiseko Shionoya, Anders Blomgren, Peter M Zygmunt, David Engblom, Edward D Högestätt, Anders Blomqvist
The mode of action of paracetamol (acetaminophen), which is widely used for treating pain and fever, has remained obscure, but may involve several distinct mechanisms, including cyclooxygenase inhibition and transient receptor potential ankyrin 1 (TRPA1) channel activation, the latter being recently associated with paracetamol's propensity to elicit hypothermia at higher doses. Here, we examined whether the antipyretic effect of paracetamol was due to TRPA1 activation or cyclooxygenase inhibition. Treatment of wild-type and TRPA1 knockout mice rendered febrile by immune challenge with LPS with a dose of paracetamol that did not produce hypothermia (150 mg/kg) but is known to be analgetic, abolished fever in both genotypes...
May 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29650049/variation-in-general-supportive-and-preventive-intensive-care-management-of-traumatic-brain-injury-a-survey-in-66-neurotrauma-centers-participating-in-the-collaborative-european-neurotrauma-effectiveness-research-in-traumatic-brain-injury-center-tbi-study
#2
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew I R Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers. METHODS: We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study...
April 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29623255/use-of-pre-hospital-medication-in-children-presenting-with-malaria-to-the-emergency-unit-of-mulago-hospital-uganda-a-descriptive-study
#3
Victor S Tumukunde, Elizabeth Kiboneka, Chandy C John, Robert O Opoka, Richard Idro
Background: Initiation of specific antimalarial treatment within 24 hrs of fever onset at home and before presentation to the hospital is one of the strategies to reduce mortality from malaria in sub-Saharan Africa. In order to determine whether this strategy is being implemented we describe the use and factors associated with the use of pre-hospital medications among children admitted with malaria in one of the tertiary hospitals in Uganda. Materials and methods: Use of pre-hospital medications was assessed in 205 children aged 6-59 months and diagnosed with malaria at admission in Mulago hospital...
July 2017: MalariaWorld Journal
https://www.readbyqxmd.com/read/29597245/the-relevancy-of-paracetamol-and-breastfeeding-post-infant-vaccination-a-systematic-review
#4
REVIEW
Nurain Suleiman, Siti Hadijah Shamsuddin, Razman Mohd Rus, Shamsul Drahman, Mai Nurul Ashikin Mohd Taib
Background: Paracetamol may be used as an antipyretic agent for the treatment of fever, as well as an analgesic in the treatment of mild to moderate pain post-vaccination in infants. The use of paracetamol during fever may be or may not be recommended since it may alter the natural human body immune response, although it may reduce pain. Objectives: The aims of this study are to describe the effectiveness of breastfeeding in reducing pain and paracetamol in reducing fever and pain post infant vaccination. Methods: Data sources and study selection was conducted by electronic searching of six databases...
March 28, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29489610/intravenous-paracetamol-overdose-a-pediatric-case-report
#5
Nagehan Aslan, Dincer Yildizdas, Didar Arslan, Ozden Ozgur Horoz, Hayri Levent Yilmaz, Sevcan Bilen
Paracetamol is a common antipyretic often used to treat children with fever and pain. With the increasing administration of intravenous (IV) paracetamol, there will be the associated risk of medication dosing errors. We report a case of IV paracetamol overdose in a child with fever during hospital admission. A IV paracetamol dosing error occurred, with delayed recognition resulting in transient hepatotoxicity, with a peak alanine transaminase of 1946 IU/L and aspartate transaminase of 1633 IU/L.
February 28, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29464465/the-concomitant-use-of-lapatinib-and-paracetamol-the-risk-of-interaction
#6
Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, Agnieszka Klupczynska, Szymon Plewa, Anna Wolc, Magdalena Magiera, Joanna Porażka, Zenon J Kokot, Edmund Grześkowiak
Lapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into three groups of eight animals in each. One group received lapatinib + paracetamol (IL + PA ), another group received lapatinib (IIL ), whereas the last group received paracetamol (IIIPA )...
February 20, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29341895/prenatal-paracetamol-exposure-and-child-neurodevelopment-a-review
#7
REVIEW
Ann Z Bauer, David Kriebel, Martha R Herbert, Carl-Gustaf Bornehag, Shanna H Swan
BACKGROUND: The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. OBJECTIVES: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. METHODS: Relevant sources were identified through a key word search of multiple databases (Medline, CINAHL, OVID and TOXNET) in September 2016...
February 2, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29327281/effect-of-early-natal-supplementation-of-paracetamol-on-attenuation-of-exotoxin-endotoxin-induced-pyrexia-and-precipitation-of-autistic-like-features-in-albino-rats
#8
Abdulaziz S Saeedan, Indu Singh, Mohd Nazam Ansari, Manjari Singh, Jitendra K Rawat, Uma Devi, Swetlana Gautam, Rajnish K Yadav, Gaurav Kaithwas
The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29322003/preliminary-phytochemical-analysis-and-in-vivo-evaluation-of-antipyretic-effects-of-hydro-methanolic-extract-of-cleome-scaposa-leaves
#9
Waheed Mumtaz Abbasi, Saeed Ahmad, Sajida Perveen, Tayyeba Rehman
Cleome scaposa has been associated with the prevention of many diseases as fever, abdominal complaints and cancer. But its antipyretic effect is not reported so far. The aim of this study was to assess the efficacy of C. scaposa in reducing temperature in Baker's yeast-induced fever model of rabbits. Rabbits were randomized into 4 groups (n = 24). Fever was induced in by Saccharomyces cerevisae (3 mL/kg of 10% suspension subcutaneous) in all study groups. Afterward, group 1, 2, 3 and 4 were orally administered with paracetamol 150 mg/kg b...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29305399/edc-impact-is-exposure-during-pregnancy-to-acetaminophen-paracetamol-disrupting-female-reproductive-development
#10
Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou, David Møbjerg Kristensen
Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29246475/estimating-primary-care-attendance-rates-for-fever-in-infants-after-meningococcal-b-vaccination-in-england-using-national-syndromic-surveillance-data
#11
Sally Harcourt, Roger A Morbey, Chris Bates, Helen Carter, Shamez N Ladhani, Simon de Lusignan, Gillian E Smith, Alex J Elliot
BACKGROUND: In September 2015, the United Kingdom became the first country to introduce the multicomponent group B meningococcal vaccine (4CMenB) into a national infant immunisation programme. In early clinical trials 51-61% of infants developed a fever when 4CMenB was administered with other routine vaccines. Whilst administration of prophylactic paracetamol is advised, up to 3% of parents may seek medical advice for fever following vaccination. We used research-level general practitioner consultations to identify any increase in attendances for all-cause fever in vaccine-eligible infants following 4CMenB introduction in England...
January 25, 2018: Vaccine
https://www.readbyqxmd.com/read/29203352/in-vivo-evaluation-of-antipyretic-effects-of-some-homeopathic-ultra-high-dilutions-on-baker-s-yeast-induced-fever-on-similia-principle
#12
Saeed Ahmad, Tayyeba Rehman, Waheed Mumtaz Abbasi
BACKGROUND: Homeopathy is a controversial alternative system of medicine. The action of homeopathic medicines is considered slow and it is assumed that homeopathic medicines are ineffective in acute conditions such as fever. OBJECTIVE: In the present study, effects of 3 homeopathic medicines on baker's yeast induced fever were investigated. MATERIALS AND METHODS: 42 local strain rabbits were equally divided into 7 groups. Normal saline was orally administered to group 1 (normal control) rabbits without fever induction...
December 1, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29039323/antipyretic-effects-of-hydro-methanol-extract-of-melia-azedarach-linn-seeds-and-cucumis-melo-linn-seeds-in-experimental-rabbits
#13
Sabira Sultana, Naveed Akhtar, Hafiz Muhammad Asif
To investigate the antipyretic activity of hydro-methanol extract of Melia azedarach Linn. (HMEMA) seeds and Cucumis melo Linn. (HMECM) seeds in experimental animals. Baker's yeast was used to induce fever in rabbits which were divided into six groups. The animal groups were thereafter administered distilled water (control), paracetamol (reference standard, 150mg/kg), HMEMA (250mg/kg), HMEMA (500mg/kg), HMECM (250mg/kg) and HMECM (500mg/kg) respectively. HMEMA and HMECM were also phytochemically screened for tannins, alkaloids, phenols, flavonoids, saponins and cardiac glycosides...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28934933/medicine-use-practices-in-management-of-symptoms-of-acute-upper-respiratory-tract-infections-in-children-%C3%A2-12-years-in-kampala-city-uganda
#14
Moses Ocan, Mary Aono, Clare Bukirwa, Emmanuel Luyinda, Cathy Ochwo, Elastus Nsambu, Stella Namugonza, Joseph Makoba, Enock Kandaruku, Hannington Muyende, Aida Nakawunde
BACKGROUND: Medicines are commonly accessed and used for management of illness in children without a prescription. This potentially increases the risk of unwanted treatment outcomes. We investigated medicine use practices in management of symptoms of acute upper respiratory tract infections among children (≤12 years) in households in Nakawa division, Kampala city. METHODS: This was a cross-sectional study conducted among 390 randomly selected children. Data on use of medicines in children (≤12 years) during recent episode of acute upper respiratory tract infection was collected from their care takers using an interviewer administered questionnaire...
September 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28931535/risk-of-hospitalisation-with-fever-following-menb-vaccination-self-controlled-case-series-analysis
#15
Heather Murdoch, Lynn Wallace, Jennifer Bishop, Chris Robertson, J Claire Cameron
OBJECTIVE: To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). DESIGN: 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled case series using linked routinely collected healthcare data, where the risk period was the 3 days immediately following receipt of a vaccine dose. PATIENTS: Children aged under 1 year in Scotland preintroduction and postintroduction of 4CMenB vaccine (pre-September 2014 to August 2015 and post-September 2015 to June 2016)...
October 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28810894/chikungunya-an-emerging-viral-infection-with-varied-clinical-presentations-in-bangladesh-reports-of-seven-cases
#16
Muhammad Abdur Rahim, Khwaja Nazim Uddin
BACKGROUND: Chikungunya is an emerging and rapidly spreading viral infection in many parts of the world including Bangladesh. It shares many epidemiological and clinical characteristics with dengue. So, a sound knowledge is required for its detection and differentiation from dengue, specially in endemic regions. CASE PRESENTATION: We present seven confirmed cases of chikungunya having different clinical presentations occurring among middle aged males and females from different socio-economic background in Dhaka city, the capital of Bangladesh...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28770976/non-steroidal-anti-inflammatory-drugs-nsaids-for-chronic-non-cancer-pain-in-children-and-adolescents
#17
REVIEW
Christopher Eccleston, Tess E Cooper, Emma Fisher, Brian Anderson, Nick Mr Wilkinson
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed and was frequently left untreated, views on children's pain have changed over time, and relief of pain is now seen as important...
August 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28766264/acetaminophen-paracetamol-induces-hypothermia-during-acute-cold-stress
#18
Josh Foster, Alexis R Mauger, Andrew Govus, David Hewson, Lee Taylor
BACKGROUND: Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (Tc ) in the absence of fever. However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen is exacerbated with cold exposure. OBJECTIVE: To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and thermal neutrality (25 °C)...
November 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28747212/sublingual-misoprostol-and-hyperpyrexia-case-report-with-temperature-curve
#19
Paul Nkemtendong Tolefac, Jacqueline Ze Minkande
BACKGROUND: Misoprostol has a wide range of applications in obstetrics and gynaecology. It is widely recommended by WHO, FIGO and ACOG for the treatment of postpartum haemorrhage due to it safety and cost-effectiveness. However, usage might be associated to hyperpyrexia and shivering. CASE PRESENTATION: We present a 30 year old Cameroonian female gravida 1 para 1 who had a vaginal delivery at 40 weeks of gestation complicated by primary postpartum haemorrhage (PPH)...
July 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28747169/optimising-decision-making-on-illness-absenteeism-due-to-fever-and-common-infections-within-childcare-centres-development-of-a-multicomponent-intervention-and-study-protocol-of-a-cluster-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
K K B Peetoom, R Crutzen, J M H A Bohnen, R Verhoeven, H J M G Nelissen-Vrancken, B Winkens, G J Dinant, J W L Cals
BACKGROUND: Evidence has shown that children 0-4 year-old attending childcare are prone to acquire infections compared to children cared for at home, with fever being the most common symptom. Illness absenteeism due to fever and common infections is substantial and mostly driven by unrealistic concerns and negative attitude towards fever of both childcare staff and parents, resulting in illness absenteeism from childcare, work absenteeism among parents and healthcare service use. The objective of this study is to optimise decision making among childcare staff on illness absenteeism due to fever and common infections in childcare...
July 26, 2017: BMC Public Health
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