keyword
https://read.qxmd.com/read/38427413/the-effect-of-body-temperature-changes-on-the-course-of-treatment-in-patients-with-pneumonia-and-sepsis-results-of-an-observational-study
#1
JOURNAL ARTICLE
Domen Guzelj, Anže Grubelnik, Nina Greif, Petra Povalej Bržan, Jure Fluher, Žiga Kalamar, Andrej Markota
BACKGROUND: Traditionally, patients who are critically ill with infection and fever have been treated with antipyretics or even physically cooled. Presumed benefits of the reduction of body temperature are mostly based on decreased metabolic demands. However, it has been shown that decreasing body temperature in patients who are critically ill is not associated with improvement in treatment outcomes. Additionally, there is some data to support the use of temperature modulation (therapeutic hyperthermia) as an adjuvant treatment strategy in patients with infection...
March 1, 2024: Interactive Journal of Medical Research
https://read.qxmd.com/read/38410320/perioperative-management-conundrum-for-a-case-with-multiple-commonly-used-drug-hypersensitivity
#2
Vikash Bansal, Habib Md R Karim, Abhishek K Rai, Dipak Bhuyan, Sanjay Kumar
Perioperative hypersensitivity reactions vary from mild to potentially fatal anaphylaxis, resulting in significant morbidity and mortality. Most of the perioperative hypersensitivity and allergic reactions are attributed to antibiotics, antiseptic solutions, latex, and opioids. In the current thrust for opioid-free anesthesia, owing to its multiple advantages, paracetamol and nonsteroidal antiinflammatory agents play a significant role in multi-modal pain and inflammatory response management. Nearly nine out of ten individuals experience postoperative pain, one-third experience postoperative nausea and vomiting, and one-fourth experience fever, irrespective of surgery and type of anesthesia, often as an inflammatory response...
January 2024: Curēus
https://read.qxmd.com/read/38356517/physicochemical-quality-assessment-of-various-brands-of-paracetamol-tablets-sold-in-freetown-municipality
#3
JOURNAL ARTICLE
Ahmed Vandy, Eugene Conteh, Michael Lahai, Marie Kolipha-Kamara, Mohamed Marah, Foday Marah, Kadiatu M Suma, Sia C Mattia, Kenneth D S Tucker, Victor S E Wray, Abass Koroma, Aiah U Lebbie
Paracetamol is a widely used over-the-counter drug for managing fever and pain, but its quality may vary among different brands, especially in low- and middle-income countries, where counterfeit and substandard medicines are prevalent. This study evaluated the physicochemical properties of fifteen brands of 500 mg paracetamol tablets sold in various pharmacies in Freetown, Sierra Leone using identification tests, friability tests, assay, dissolution tests, and mass variation. The results showed that three brands were not registered with the Pharmacy Board of Sierra Leone, and two brands did not meet the requirement for labelling (no manufacturing date)...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38348296/surface-engineering-of-carbon-microspheres-with-nanoceria-wrapped-on-mwcnts-a-dual-electrocatalyst-for-simultaneous-monitoring-of-molnupiravir-and-paracetamol
#4
JOURNAL ARTICLE
Yahya S Alqahtani, Ashraf M Mahmoud, Mohamed M El-Wekil, Hossieny Ibrahim
In the present study, nanoceria-decorated MWCNTs (CeNPs@MWCNTs) were synthesized using a simple and inexpensive process. Molnupiravir (MPV) has gained considerable attention in recent years due to the infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Since some people infected with COVID-19 experience fever and headaches, paracetamol (PCM) has been prescribed to relieve these symptoms. Therefore, there is an urgent need to monitor and detect these drugs simultaneously in pharmaceutical and biological samples...
February 7, 2024: RSC Advances
https://read.qxmd.com/read/38286691/protocol-for-fever-control-using-external-cooling-in-mechanically-ventilated-patients-with-septic-shock-sepsiscool-ii-randomised-controlled-trial
#5
JOURNAL ARTICLE
Armelle Guénégou-Arnoux, Juliette Murris, Stéphane Bechet, Camille Jung, Johann Auchabie, Julien Dupeyrat, Nadia Anguel, Pierre Asfar, Julio Badie, Dorothée Carpentier, Benjamin Chousterman, Jeremy Bourenne, Agathe Delbove, Jérôme Devaquet, Nicolas Deye, Guillaume Dumas, Anne-Florence Dureau, Jean-Baptiste Lascarrou, Stephane Legriel, Christophe Guitton, Caroline Jannière-Nartey, Jean-Pierre Quenot, Jean-Claude Lacherade, Julien Maizel, Armand Mekontso Dessap, Bruno Mourvillier, Philippe Petua, Gaetan Plantefeve, Jean-Christophe Richard, Alexandre Robert, Clément Saccheri, Ly Van Phach Vong, Sandrine Katsahian, Frédérique Schortgen
INTRODUCTION: Fever treatment is commonly applied in patients with sepsis but its impact on survival remains undetermined. Patients with respiratory and haemodynamic failure are at the highest risk for not tolerating the metabolic cost of fever. However, fever can help to control infection. Treating fever with paracetamol has been shown to be less effective than cooling. In the SEPSISCOOL pilot study, active fever control by external cooling improved organ failure recovery and early survival...
January 29, 2024: BMJ Open
https://read.qxmd.com/read/38255358/the-dangers-of-acetaminophen-for-neurodevelopment-outweigh-scant-evidence-for-long-term-benefits
#6
REVIEW
William Parker, Lauren G Anderson, John P Jones, Rachel Anderson, Lauren Williamson, Dillan Bono-Lunn, Zacharoula Konsoula
Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations in humans, correlations in time, and pharmacological/toxicological considerations, it has been concluded without reasonable doubt and with no evidence to the contrary that exposure of susceptible babies and children to acetaminophen (paracetamol) induces many, if not most, cases of autism spectrum disorder (ASD). However, the relative number of cases of ASD that might be induced by acetaminophen has not yet been estimated...
December 29, 2023: Children
https://read.qxmd.com/read/38077267/efficacy-of-oral-mefenamic-acid-versus-paracetamol-as-a-prophylactic-analgesic-for-needle-pain-in-children-receiving-vaccination-a-three-arm-parallel-triple-blind-placebo-controlled-map-vac-randomized-controlled-trial
#7
JOURNAL ARTICLE
Rachna Pasi, Thirunavukkarasu Arun Babu, Vinoth Kumar Kallidoss
BACKGROUND: Needle pain due to routine vaccination is an important factor contributing to low vaccine adherence and immunization coverage. Prophylactic oral analgesics can address this important issue of needle pain related to vaccination. Paracetamol and mefenamic acid are commonly used nonsteroidal anti-inflammatory drugs for pain relief, but there is little published literature on whether the same can be used for needle pain related to vaccination. OBJECTIVES: This study was planned to compare the efficacy of oral mefenamic acid and paracetamol over placebo as a prophylactic analgesic during vaccination and prophylactic antipyretic during the post-vaccination period...
2023: Therapeutic Advances in Vaccines and Immunotherapy
https://read.qxmd.com/read/38074444/prevention-of-infections-and-fever-to-improve-outcome-in-older-patients-with-acute-stroke-precious-a-randomised-open-phase-iii-multifactorial-clinical-trial-with-blinded-outcome-assessment
#8
JOURNAL ARTICLE
Jeroen C de Jonge, Wouter M Sluis, Hendrik Reinink, Philip M Bath, Lisa J Woodhouse, Berber Zweedijk, Diederik van de Beek, Anne Hege Aamodt, Iris Alpers, Alfonso Ciccone, Laszlo Csiba, Jacques Demotes, Janika Kõrv, Iwona Kurkowska-Jastrzebska, Jesse Dawson, Malcolm R Macleod, George Ntaios, Sven Poli, Haralampos Milionis, Stefano Ricci, Silvia Cenciarelli, Paolo Candelaresi, Sebastiaan Ftm de Bruijn, Rohan Pathansali, Kailash Krishnan, Brian Clarke, Götz Thomalla, H Bart van der Worp
BACKGROUND: Infections and fever after stroke are associated with poor functional outcome or death. We assessed whether prophylactic treatment with anti-emetic, antibiotic, or antipyretic medication would improve functional outcome in older patients with acute stroke. METHODS: We conducted an international, 2∗2∗2-factorial, randomised, controlled, open-label trial with blinded outcome assessment in patients aged 66 years or older with acute ischaemic stroke or intracerebral haemorrhage and a score on the National Institutes of Health Stroke Scale ≥ 6...
January 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38062478/development-and-validation-of-chemometric-assisted-spectrophotometric-models-for-efficient-quantitation-of-a-binary-mixture-of-supportive-treatments-in-covid-19-in-the-presence-of-its-toxic-impurities-a-comparative-study-for-eco-friendly-assessment
#9
JOURNAL ARTICLE
Heidi R Abd El-Hadi, Maya S Eissa, Hala E Zaazaa, Basma M Eltanany
The use of sustainable solvents has increased significantly in recent years due to advancements in green analytical methods. The number of impurities in the drug substance determines how safe the finished product is. Therefore, during the whole medication planning process, contaminants need to be closely watched. Using chemometric models, the concentrations of hyoscine N-butyl bromide (HYO) and paracetamol (PAR) were determined in the presence of three PAR impurities [P-nitrophenol (PNP), P-aminophenol (PAP), and P-chloroacetanilide (PCA), as well as DL-tropic acid (TRO) as a HYO impurity]...
December 7, 2023: BMC chemistry
https://read.qxmd.com/read/38027045/ceftriaxone-use-evaluation-in-western-zone-tigray-hospitals-ethiopia-a-retrospective-cross-sectional-study
#10
JOURNAL ARTICLE
Tewodros Shegute, Mulugeta Hiruy, Haftom Hadush, Leake Gebremeskel
BACKGROUND: Drug use evaluation is a systematic approach to determining the appropriateness of drug use, identifying drug therapy problems, and proposing interventions. Ceftriaxone is one of the most widely used drugs in hospitals, requiring the performance of drug use evaluation. This study was aimed at evaluating the appropriateness of ceftriaxone use at Kahsay Abera and Mearg hospitals in the Western zone of Tigray, Ethiopia. METHODS: An institution-based retrospective cross-sectional study design was conducted in both hospitals from December 2015 to August 2016 using standardized and pretested data collection formats...
2023: BioMed Research International
https://read.qxmd.com/read/37954757/comparing-the-efficacy-of-paracetamol-ibuprofen-and-a-combination-of-the-two-drugs-in-relieving-pain-and-fever-in-the-pediatric-age-group-a-prospective-observational-study
#11
JOURNAL ARTICLE
Vivek Charde, Mukesh Sanklecha, Priyank Rajan, Ravi V Sangoi, Prashanth A, Amisha Palande, Pranav Dighe, Ruchi Kothari, Gaurav Mittal
Introduction Fever and pain are common afflictions in the pediatric population, prompting the use of paracetamol and ibuprofen as primary treatment options. However, a comprehensive understanding of their comparative efficacy, safety profiles, and potential combined use remains crucial for informed clinical decision-making. In this prospective observational study, we aimed to delve into these aspects, shedding light on the optimal management strategies for fever and pain in pediatric patients. Methodology A total of 108 children were enrolled and categorized into three groups, namely, paracetamol monotherapy, ibuprofen monotherapy, and a combination of both drugs...
October 2023: Curēus
https://read.qxmd.com/read/37938932/isolation-preparation-and-investigation-of-leaf-extracts-of-aloe-barbadensis-for-its-remedial-effects-on-tumor-necrosis-factor-alpha-tnf-%C3%AE-and-interleukin-il-6-by-in-vivo-and-in-silico-approaches-in-experimental-rats
#12
JOURNAL ARTICLE
Iram Khurshaid, Sobia Ilyas, Nureen Zahra, Suhail Ahmad, Tariq Aziz, Fahad Al-Asmari, Sanaa Almowallad, Rehab F Al-Massabi, Yasmene F Alanazi, Aminah A Barqawi, Roaa Mohammed Tahir Kassim, Abdulhakeem S Alamri, Majid Alhomrani, Manal Y Sameeh
Aloe barbadensis is a stemless plant with a length of 60-100 cm with juicy leaves which is used for its remedial and healing properties in different suburbs of various countries. The present study was conducted to investigate the effect of A. barbadensis leaf extract (aqueous and ethanolic) in yeast induced pyrexia and acetic acid induced writhing in rat model to evaluate the antipyretic biomarkers and its phytochemical screening with computational analysis. For analgesic activity model 60 Albino rats (160-200 kg) were divided into four groups...
November 8, 2023: Acta Biochimica Polonica
https://read.qxmd.com/read/37891052/adverse-events-following-immunization-aefis-with-anti-meningococcus-type-b-vaccine-4cmenb-data-of-post-marketing-active-surveillance-program-apulia-region-italy-2019-2023
#13
JOURNAL ARTICLE
Pasquale Stefanizzi, Antonio Di Lorenzo, Andrea Martinelli, Lorenza Moscara, Paolo Stella, Domenica Ancona, Silvio Tafuri
The four-component recombinant-DNA anti-meningococcus B vaccine (4CMenB) has been approved by the European Medicines Agency in 2013. In Italy, 4CMenB is recommended since 2017 for use in infants under one year of age. Due to the strong evidence of increased risk of fever after administration, surveillance of adverse events following immunization (AEFIs) is a priority for 4CMenB. This cross-sectional prospective study aims at investigating 4CMenB's safety profile. The study population is represented by infants under twelve months of age vaccinated with 4CMenB in selected ambulatories in Apulia, a region in South-Eastern Italy, from October 1st, 2020, to March 31st, 2023...
October 26, 2023: Vaccine
https://read.qxmd.com/read/37885398/-autochthonous-case-of-malaria-prediagnosed-as-leukemia
#14
JOURNAL ARTICLE
Hüseyin Gülen, Ayşe Türedi Yıldırım, İbrahim Çavuş, Hülya Türkmen, Ahmet Özbilgin
Malaria is a parasitic disease transmitted by infected female Anopheles mosquitoes. There are five species of Plasmodium species that can infect humans. Of these species, especially P.falciparum and P.vivax pose the greatest threat to human health. In the 2014 report of the World Health Organization, it was reported that there were no locally acquired cases of malaria in 16 countries including Türkiye. Malaria cases originating from outside the country and imported due to migration, travel and working abroad are reported as import cases...
October 2023: Mikrobiyoloji Bülteni
https://read.qxmd.com/read/37877108/kikuchi-fujimoto-disease-a-case-of-febrile-cervical-lymphadenopathy-with-hematological-abnormalities
#15
Dong Eun Lee, Min Gyoung Pak, Sung-Hyun Kim, Christopher Chandler
Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign but rare disorder associated with febrile cervical lymphadenopathy in young adults. Here, we discuss a case of a young female patient presenting with left tender cervical lymphadenopathy that progressed bilaterally with a fever of unknown origin. Laboratory parameters showed persistent leukopenia, especially neutropenia, which fluctuated with the degree of symptom severity. Two months were taken to confirm the diagnosis of KFD based on the histological interpretation of the lymph node biopsy...
October 2023: Curēus
https://read.qxmd.com/read/37834259/non-steroidal-anti-inflammatory-drug-effect-on-the-binding-of-plasma-protein-with-antibiotic-drug-ceftazidime-spectroscopic-and-in-silico-investigation
#16
JOURNAL ARTICLE
Mohd Sajid Ali, Ekampreet Singh, Jayaraman Muthukumaran, Hamad A Al-Lohedan
The coexistence of ceftazidime, which is a popular third-generation of cephalosporin antibiotic, with ubiquitous paracetamol or acetaminophen, is very likely because the latter is given to the patients to reduce fever due to bacterial infection along with an antibiotic such as the former. Therefore, in this study, we investigated the detailed binding of ceftazidime with plasma protein, human serum albumin (HSA), in the absence and presence of paracetamol using spectroscopic techniques such as fluorescence, UV-visible, and circular dichroism, along with in silico methods such as molecular docking, molecular dynamics simulations, and MM/PBSA-based binding free energy analysis...
September 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37818518/a-rare-case-of-cytomegalovirus-retinitis-in-a-young-immunocompetent-patient
#17
Ruchi Shukla, Ashutosh K Mishra, Archana Verma, Pragati Garg, Shrinkhal Lnu
Cytomegalovirus (CMV) is known to be the most common opportunistic infection in immunocompromised cases, and CMV retinitis is the most common ocular manifestation. Severe retinitis with involvement of the macula or retinal necrosis can lead to vision loss. Prompt diagnosis and treatment can restrict the disease's progression. We describe the case of a 30-year-old man who presented with the chief complaint of progressive diminution of vision in both eyes for 15 days. Diminution of vision was associated with fever and skin rashes...
September 2023: Curēus
https://read.qxmd.com/read/37791590/immediate-versus-delayed-versus-no-antibiotics-for-respiratory-infections
#18
REVIEW
Geoffrey Kp Spurling, Liz Dooley, Justin Clark, Deborah A Askew
BACKGROUND: Concerns exist regarding antibiotic prescribing for respiratory tract infections (RTIs) owing to adverse reactions, cost and antibacterial resistance. One proposed strategy to reduce antibiotic prescribing is to provide prescriptions, but to advise delay in antibiotic use with the expectation that symptoms will resolve first. This is an update of a Cochrane Review originally published in 2007, and updated in 2010, 2013 and 2017. OBJECTIVES: To evaluate the effects on duration and/or severity of clinical outcomes (pain, malaise, fever, cough and rhinorrhoea), antibiotic use, antibiotic resistance and patient satisfaction of advising a delayed prescription of antibiotics in respiratory tract infections...
October 4, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37786648/symptoms-trend-and-challenges-in-dental-practice-during-delta-variance-covid-19-pandemic-in-indonesia-google-trends-analysis
#19
JOURNAL ARTICLE
Faizul Hasan, Noor Rohmah Mayasari, Eisner Salamanca, Odontuya Dorj, Rahmat Dani Satria, Kamaluddin Latief, Mokh Sujarwadi, Hendrik Setia Budi
Background: The COVID-19 pandemic has grown to be a serious issue on a global scale. Dental care is one of the industries affected by COVID-19. The surveillance utilizing lifetime data, however, is still not clear. The purpose of this study was to use Google Trends (GT) analysis to examine symptom trends and challenges during the COVID-19 outbreak in Indonesia. Methods: Covid-19 cases retrieve from Our World in Data. The cases were collected between 1 April 2021-30 September 2021. The GT was used to discover Indonesian relative search volume (RSVs) covering the timeframe of the first outbreak covid-19 pandemic in Indonesia on 1 March 2020 until 13 February 2022...
2023: F1000Research
https://read.qxmd.com/read/37766169/the-effectiveness-of-paracetamol-to-reduce-the-post-vaccination-sars-cov-2-adverse-effects-in-an-italian-vaccination-center
#20
JOURNAL ARTICLE
Eleonora Ricci, Anamaria Glavasc, Barbara Morandini, Maria Caterina Grassi, Giuseppe La Torre
The arrival of specific vaccines was crucial for the eradication of COVID-19. Despite the security of the vaccination, the administration of COVID-19 mRNA vaccines often causes systemic side effects for a short time after the injection, such as headache, fatigue, fever, muscle pain and nausea. These side effects can limit the adherence to COVID-19 vaccines administration, especially in healthcare workers. This study aims to analyze the impact of the prophylactic use of paracetamol to reduce the post-vaccination Comirnaty/Pfizer adverse effects...
September 15, 2023: Vaccines
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