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https://www.readbyqxmd.com/read/28810894/chikungunya-an-emerging-viral-infection-with-varied-clinical-presentations-in-bangladesh-reports-of-seven-cases
#1
Muhammad Abdur Rahim, Khwaja Nazim Uddin
BACKGROUND: Chikungunya is an emerging and rapidly spreading viral infection in many parts of the world including Bangladesh. It shares many epidemiological and clinical characteristics with dengue. So, a sound knowledge is required for its detection and differentiation from dengue, specially in endemic regions. CASE PRESENTATION: We present seven confirmed cases of chikungunya having different clinical presentations occurring among middle aged males and females from different socio-economic background in Dhaka city, the capital of Bangladesh...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28770976/non-steroidal-anti-inflammatory-drugs-nsaids-for-chronic-non-cancer-pain-in-children-and-adolescents
#2
REVIEW
Christopher Eccleston, Tess E Cooper, Emma Fisher, Brian Anderson, Nick Mr Wilkinson
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed and was frequently left untreated, views on children's pain have changed over time, and relief of pain is now seen as important...
August 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28766264/acetaminophen-paracetamol-induces-hypothermia-during-acute-cold-stress
#3
Josh Foster, Alexis R Mauger, Andrew Govus, David Hewson, Lee Taylor
BACKGROUND: Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (T c) in the absence of fever. However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen is exacerbated with cold exposure. OBJECTIVE: To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and thermal neutrality (25 °C)...
August 1, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28747212/sublingual-misoprostol-and-hyperpyrexia-case-report-with-temperature-curve
#4
Paul Nkemtendong Tolefac, Jacqueline Ze Minkande
BACKGROUND: Misoprostol has a wide range of applications in obstetrics and gynaecology. It is widely recommended by WHO, FIGO and ACOG for the treatment of postpartum haemorrhage due to it safety and cost-effectiveness. However, usage might be associated to hyperpyrexia and shivering. CASE PRESENTATION: We present a 30 year old Cameroonian female gravida 1 para 1 who had a vaginal delivery at 40 weeks of gestation complicated by primary postpartum haemorrhage (PPH)...
July 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28747169/optimising-decision-making-on-illness-absenteeism-due-to-fever-and-common-infections-within-childcare-centres-development-of-a-multicomponent-intervention-and-study-protocol-of-a-cluster-randomised-controlled-trial
#5
K K B Peetoom, R Crutzen, J M H A Bohnen, R Verhoeven, H J M G Nelissen-Vrancken, B Winkens, G J Dinant, J W L Cals
BACKGROUND: Evidence has shown that children 0-4 year-old attending childcare are prone to acquire infections compared to children cared for at home, with fever being the most common symptom. Illness absenteeism due to fever and common infections is substantial and mostly driven by unrealistic concerns and negative attitude towards fever of both childcare staff and parents, resulting in illness absenteeism from childcare, work absenteeism among parents and healthcare service use. The objective of this study is to optimise decision making among childcare staff on illness absenteeism due to fever and common infections in childcare...
July 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28737843/non-steroidal-anti-inflammatory-drugs-nsaids-for-cancer-related-pain-in-children-and-adolescents
#6
REVIEW
Tess E Cooper, Lauren C Heathcote, Brian Anderson, Marie-Claude Grégoire, Gustaf Ljungman, Christopher Eccleston
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for persisting pain in children acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time and relief of pain is now seen as important. In the past, pain was largely dismissed and was frequently left untreated, and it was assumed that children quickly forgot about painful experiences...
July 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28720398/perinatal-and-neonatal-use-of-paracetamol-for-pain-relief
#7
REVIEW
Karel Allegaert, John N van den Anker
Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a focused analysis. During pregnancy, there is an important increase in paracetamol clearance. Consequently, it is reasonable to anticipate that the analgesic effect of paracetamol will decrease faster, whereas higher doses may result in even higher oxidative toxic metabolites. Therefore, most peripartal PD data relate to multimodal analgesia strategies...
October 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28637642/emergency-department-attendance-following-4-component-meningococcal-b-vaccination-in-infants
#8
Sarah Kapur, Thomas Bourke, Julie-Ann Maney, Paul Moriarty
INTRODUCTION: In September 2015, the UK became the first country in the world to introduce the 4-component meningococcal B vaccine(4CMenB) into the routine vaccine schedule for infants. 4CMenB is known to cause fever in infants. Infants presenting with fever, particularly those under 3 months, have a significant risk of serious bacterial infection(SBI). METHOD: Between September 2015 and January 2016, we performed a prospective audit of management of infants between 30 and 180 days attending the regional paediatric emergency department(ED) in Northern Ireland, within 4 days of receiving 4CMenB...
June 21, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28609439/interventions-for-treating-patients-with-chikungunya-virus-infection-related-rheumatic-and-musculoskeletal-disorders-a-systematic-review
#9
Arturo Martí-Carvajal, Pilar Ramon-Pardo, Emilie Javelle, Fabrice Simon, Sylvain Aldighieri, Hacsi Horvath, Julia Rodriguez-Abreu, Ludovic Reveiz
BACKGROUND: Chikungunya virus infection (CHIKV) is caused by a mosquito-borne alphavirus. CHIKV causes high fever and painful rheumatic disorders that may persist for years. Because little is known about interventions for treating CHIKV-related illness, we conducted a systematic review. METHODS: We used Cochrane methods. We searched PubMed, EMBASE, Cochrane Library, LILACS and other sources from the earliest records to March 2016. We had no language restrictions...
2017: PloS One
https://www.readbyqxmd.com/read/28559473/paracetamol-acetaminophen-impairs-brain-masculinisation
#10
Anders Hay-Schmidt, Olivia Finkielman, Benjamin Jensen, Christine Høgsbro, Jacob Bak Holm, Kristoffer Haurum Johansen, Tina Kold Jensen, Anderson Martino Andrade, Shanna Swan, Carl-Gustaf Bornehag, Søren Brunak, Bernard Jegou, Karsten Kristiansen, David Møbjerg Kristensen
Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinized during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood...
May 30, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28494851/effects-of-homoeopathic-ultrahigh-dilutions-of-aconitum-napellus-on-baker-s-yeast-induced-fever-in-rabbits
#11
Saeed Ahmad, Tayyeba Rehman, Waheed Mumtaz Abbasi
OBJECTIVE: To evaluate the effects of homoeopathic ultrahigh dilutions of Aconitum napellus in Baker's yeast-induced fever in rabbits. METHODS: Rabbits were divided into 4 groups and each group contained 6 rabbits. Baker's yeast suspension (20%) was injected subcutaneously. After fever induction, paracetamol and homoeopathic ultrahigh dilutions (A. napellus 200c and 1 000c) were given orally. Rectal temperature was measured with digital thermometer hourly. RESULTS: Fever was induced in all the rabbits after 4 hours of Baker's yeast administration...
May 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28473508/uk-parents-attitudes-towards-meningococcal-group-b-menb-vaccination-a-qualitative-analysis
#12
Cath Jackson, Joanne Yarwood, Vanessa Saliba, Helen Bedford
OBJECTIVES: (1) To explore existing knowledge of, and attitudes, to group B meningococcal disease and serogroup B meningococcal (MenB) vaccine among parents of young children. (2) To seek views on their information needs. DESIGN: Cross-sectional qualitative study using individual and group interviews conducted in February and March 2015, prior to the introduction of MenB vaccine (Bexsero) into the UK childhood immunisation schedule. SETTING: Community centres, mother and toddler groups, parents' homes and workplaces in London and Yorkshire...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28452026/micro-sized-tio2-as-photoactive-catalyst-coated-on-industrial-porcelain-gr%C3%A3-s-tiles-to-photodegrade-drugs-in-water
#13
Claudia L Bianchi, Benedetta Sacchi, Sofia Capelli, Carlo Pirola, Giuseppina Cerrato, Sara Morandi, Valentino Capucci
Pharmaceutical compounds and their metabolites raise worrying questions because of their continuous release and lack of efficient removal by conventional wastewater treatments; therefore, they are being detected in groundwater, surface water and drinking water in increasing concentrations. Paracetamol and aspirin are two of the most commonly used drugs employed as fever reducer, analgesic and anti-inflammatory. They and their metabolites are very often found in river water, so their degradation is necessary in order to render water suitable for human consumption...
April 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28449972/effect-of-prophylactic-or-therapeutic-administration-of-paracetamol-on-immune-response-to-dtwp-hepb-hib-combination-vaccine-in-indian-infants
#14
Arijit Sil, Mandyam D Ravi, Badri N Patnaik, Mandeep S Dhingra, Martin Dupuy, Dulari J Gandhi, Sangappa M Dhaded, Anand P Dubey, Ritabrata Kundu, Sanjay K Lalwani, Jugesh Chhatwal, Leni G Mathew, Madhu Gupta, Shiv D Sharma, Sandeep B Bavdekar, Soumya P Rout, Midde V Jayanth, Naveena A D'Cor, Somnath A Mangarule, Suresh Ravinuthala, Jagadeesh Reddy E
BACKGROUND: Vaccination is considered as the most cost effective method for preventing infectious diseases. Low grade fever is a known adverse effect of vaccination. In India, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. Some studies have shown that paracetamol interferes with antibody responses following immunization. This manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in Indian infants where paracetamol was not used or was used either as prophylaxis or for treatment of fever...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28448685/adult-neurobehavioral-alterations-in-male-and-female-mice-following-developmental-exposure-to-paracetamol-acetaminophen-characterization-of-a-critical-period
#15
Gaëtan Philippot, Torsten Gordh, Anders Fredriksson, Henrik Viberg
Paracetamol (acetaminophen) is a widely used non-prescription drug with analgesic and antipyretic properties. Among pregnant women and young children, paracetamol is one of the most frequently used drugs and is considered the first-choice treatment for pain and/or fever. Recent findings in both human and animal studies have shown associations between paracetamol intake during brain development and adverse behavioral outcomes later in life. The present study was undertaken to investigate if the induction of these effects depend on when the exposure occurs during a critical period of brain development and if male and female mice are equally affected...
April 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28437025/effectiveness-of-paracetamol-versus-ibuprofen-administration-in-febrile-children-a-systematic-literature-review
#16
Kaajal Narayan, Simon Cooper, Julia Morphet, Kelli Innes
AIM: The use of antipyretics to manage the febrile child is becoming increasingly popular. Paracetamol and ibuprofen are the most commonly used interventions to manage fever in children; however, there have been no comparative analyses. The aim of the study is to evaluate the evidence comparing paracetamol to ibuprofen in the treatment of fever in children. METHODS: A systematic review of randomised controlled trials investigating the administration of oral paracetamol and ibuprofen to reduce fever in children...
August 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28435330/first-case-of-imported-chikungunya-infection-in-croatia-2016
#17
Boris Luksic, Nenad Pandak, Edita Drazic-Maras, Svjetlana Karabuva, Mislav Radic, Andrea Babic-Erceg, Ljubo Barbic, Vladimir Stevanovic, Tatjana Vilibic-Cavlek
In recent years, several European countries reported cases of imported chikungunya infection. We present the first imported clinically manifested chikungunya fever in Croatia. A 27-year-old woman returned to Croatia on 21 March 2016, after she stayed in Costa Rica for two months where she had noticed a mosquito bite on her left forearm. Five days after the mosquito bite she developed severe arthralgias, fever and erythematous papular rash. In next few days symptoms gradually subsided. After ten days she felt better, but arthralgias re-appeared accompanied with morning stiffness...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28380408/haemodynamic-changes-with-paracetamol-in-critically-ill-children
#18
Samiran Ray, Thomas Brick, Sainath Raman, Paul J Birrell, Nigel J Klein, Mark J Peters
PURPOSE: Paracetamol has been associated with a reduction in blood pressure, especially in febrile, critically-ill adults. We hypothesised that blood pressure would fall following administration of paracetamol in critically-ill children and this effect would be greater during fever and among children with a high body surface area to weight ratio. METHODS: A 12-month prospective observational study of children (0-16years) admitted to paediatric intensive care, who underwent pulse contour analysis and received paracetamol concurrently...
March 30, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28351439/-revision-of-the-dutch-college-of-general-practitioners-practice-guideline-children-with-fever
#19
W E Eizenga, W Opstelten
- Fever in children is usually caused by benign viral infection.- Approximately 1-10% of children with fever has or develops a serious infection such as pneumonia, meningitis or pyelonephritis.- It is more important to timely recognize symptoms that may indicate a potentially serious disease course than to make an exact diagnosis.- Children < 3 months are at greater risk for a serious disease course.- During follow-up it is important to provide parents with proper advice on the expected disease course and who they should contact, and when, in cases of deterioration or concern...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28303989/frequency-of-worsening-liver-function-in-severe-dengue-hepatitis-patients-receiving-paracetamol-a-retrospective-analysis-of-hospital-data
#20
Ahsan Ali Syed, Faisal Aslam, Haris Hakeem, Faraz Siddiqui, Noreen Nasir
OBJECTIVE: To determine the frequency of worsening liver function among hospital in-patients with severe dengue hepatitis receiving paracetamol. METHODS: This retrospective study was conducted at the Department of Medicine, Aga Khan University Hospital, Karachi, and comprised records of dengue patients with severe hepatitis who received paracetamol for control of fever between June 2007 and December 2014. Alanine aminotransferase at baseline and following paracetamol administration was noted, as well as dosage and duration of paracetamol, along with participants' demographic details...
March 2017: JPMA. the Journal of the Pakistan Medical Association
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