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JOURNAL ARTICLE
Claudia Der-Martirosian, Marlena Shin, Michelle L Upham, Jamie H Douglas, Steven B Zeliadt, Stephanie L Taylor
Background: Complementary and integrative health (CIH) therapies, such as in-person acupuncture, chiropractic care, and meditation, are evidence-based nonpharmaceutical treatment options for pain. During COVID-19, the Veterans Health Administration (VA) delivered several CIH therapies virtually. This study explores veterans' utilization, advantages/disadvantages, and delivery issues of yoga, Tai Chi, meditation/mindfulness (self-care), and massage, chiropractic, and acupuncture (practitioner-delivered care), using telephone/video at 18 VA sites during COVID-19...
July 22, 2022: Telemedicine Journal and E-health
#22
RANDOMIZED CONTROLLED TRIAL
Belle Zaccari, Athena D F Sherman, Sarah Febres-Cordero, Melinda Higgins, Ursula Kelly
OBJECTIVE: The study objective was to explore the preliminary efficacy of trauma-sensitive yoga compared to cognitive processing therapy (CPT) for women Veterans with posttraumatic stress disorder (PTSD) related to military sexual trauma (MST) in a pilot randomized control trial (RCT). We then compared these results to published interim results for the subsequent full-scale RCT. METHOD: The analytic sample included women Veterans (N = 41) with PTSD related to MST accessing healthcare in a southeastern Veterans Affairs Health Care System...
November 2022: Complementary Therapies in Medicine
#23
JOURNAL ARTICLE
Ankit Shroff, Taras Y Nazarko
SQSTM1/p62 (sequestosome 1) is a well-established indicator of macroautophagic/autophagic flux. It was initially characterized as the ubiquitin-binding autophagic receptor in aggrephagy, the selective autophagy of ubiquitinated protein aggregates. Recently, several studies correlated its levels with the abundance of intracellular lipid droplets (LDs). In the absence of a bona fide receptor for the selective autophagy of LDs (lipophagy), a few studies demonstrated the role of SQSTM1 in lipophagy. Our analysis of these studies shows that SQSTM1 colocalizes with LDs, bridges them with phagophores, is co-degraded with them in the lysosomes, and affects LD abundance in a variety of cells and under diverse experimental conditions...
July 7, 2022: Autophagy
#24
JOURNAL ARTICLE
R Jay Schulz-Heik, Laura C Lazzeroni, Beatriz Hernandez, Timothy J Avery, Danielle C Mathersul, Julia S Tang, Emily Hugo, Peter J Bayley
Background: Valued living is the extent to which an individual's behavior is consistent with what they believe is important or good. It is unknown whether many complementary and integrative treatments and psychotherapies for posttraumatic stress disorder enhance valued living, and for whom. Objectives: Measure within- and between-group changes in valued living in Veterans who completed cognitive processing therapy (CPT) and sudarshan kriya yoga (SKY) for posttraumatic stress disorder (PTSD); evaluate moderators of improvement...
2022: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
#25
JOURNAL ARTICLE
Godfred O Boateng, Ellis Adjei Adams
BACKGROUND: Housing insecurity is a pervasive challenge in the cities and urban areas of low-income and middle-income countries (LMICs), particularly in the informal settlements where disproportionately high number of urban residents live. Despite this persistent challenge and its impact on health and well-being, there are currently no comprehensive, standardised, and validated instruments for measuring housing insecurity in these regions. We aimed to develop and validate a housing insecurity scale that can be used in urban slums and informal settlements in LMICs...
March 2022: Lancet Global Health
#26
JOURNAL ARTICLE
Jari Tiihonen, Antti Tanskanen, J Simon Bell, Jessica L Dawson, Vesa Kataja, Heidi Taipale
BACKGROUND: Clozapine is the most efficacious treatment for schizophrenia and is associated with lower overall mortality than are other antipsychotic drugs, despite the risk of agranulocytosis. Preliminary reports over the past 10 years suggest a possible risk of haematological malignancies, but the issue has remained unsettled. We aimed to study the risk of haematological malignancies associated with use of clozapine and other antipsychotics. METHODS: We did a nationwide case-control (and cohort) study of people with schizophrenia, using prospectively gathered data from Finnish national registers...
May 2022: Lancet Psychiatry
#27
JOURNAL ARTICLE
George N Ioannou, Emily R Locke, Ann M O'Hare, Amy S B Bohnert, Edward J Boyko, Denise M Hynes, Kristin Berry
BACKGROUND: Little is known about real-world COVID-19 vaccine effectiveness (VE) in racially and ethnically diverse, elderly populations with high comorbidity burden. OBJECTIVE: To determine the effectiveness of messenger RNA COVID-19 vaccines. DESIGN: Target trial emulation study comparing newly vaccinated persons with matched unvaccinated controls. SETTING: U.S. Department of Veterans Affairs health care system. PARTICIPANTS: Among persons receiving care in the Veterans Affairs health care system ( n = 5 766 638), those who received at least 1 dose of the Moderna or Pfizer-BioNTech COVID-19 vaccine from 11 December 2020 to 25 March 2021 ( n = 2 099 871) were matched to unvaccinated controls in a 1:1 ratio according to demographic, clinical, and geographic characteristics...
March 2022: Annals of Internal Medicine
#28
REVIEW
Amanda K A Silva, Marie Morille, Max Piffoux, Surendar Arumugam, Phlippe Mauduit, Jérôme Larghero, Arnaud Bianchi, Kelly Aubertin, Olivier Blanc-Brude, Danièle Noël, Emilie Velot, Célia Ravel, Céline Elie-Caille, Anna Sebbagh, Chantal Boulanger, Claire Wilhelm, Gabriel Rahmi, Isabelle Raymond-Letron, Kondareddy Cherukula, Tristan Montier, Christophe Martinaud, Jean-Marie Bach, Olivier Favre-Bulle, Jolanda Spadavecchia, Christian Jorgensen, Philippe Menasché, Clotilde Aussel, Joël Chopineau, Mathilde Mosser, Matti Ullah, Nicolas Sailliet, Nathalie Luciani, Noëlle Mathieu, Pierre-Emmanuel Rautou, Sophie Brouard, Wilfrid Boireau, Sébastien Jauliac, Marianne Dedier, Jean-Hugues Trouvin, Florence Gazeau, Marina Trouillas, Juliette Peltzer, Antoine Monsel, Sébastien Banzet
Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate quality, safety, and efficacy, as required for any medicinal product. EV research translation into medicinal products is an exciting and challenging perspective. Recent papers, provide important guidance on regulatory aspects of pharmaceutical development, defining EVs for therapeutic applications and critical considerations for the development of potency tests...
December 2021: Advanced Drug Delivery Reviews
#29
JOURNAL ARTICLE
Kevin Liu, Esmeralda Madrigal, Joyce S Chung, Mira Parekh, Colin S Kalahar, Donald Nguyen, Molly Timmerman, Odette A Harris
CONTEXT: Studies have found evidence for meditation's positive effects on health and well-being, but the difficulty of learning and engaging in meditation practice has been identified as a major barrier. Virtual reality (VR) technology may facilitate meditation practice by immersing users in a distraction-free and calming virtual environment, although this theory has yet to be rigorously tested. OBJECTIVE: This study intended to examine the efficacy of VR-guided meditation in a population of US veterans as a tool to facilitate meditation and relaxation practice for reduction of stress and chronic pain as well as to elicit participants' feedback regarding their perceptions of VR-guided meditation...
September 24, 2021: Alternative Therapies in Health and Medicine
#30
JOURNAL ARTICLE
Ernest R Vina, Ada O Youk, Cristian Quinones, C Kent Kwoh, Said A Ibrahim, Leslie R M Hausmann
OBJECTIVE: To evaluate race and gender variations in complementary and alternative medicine (CAM) use for knee osteoarthritis (OA) (unadjusted and adjusted for demographic and clinical factors). METHODS: A secondary analysis of cross-sectional data was conducted. The sample included Veterans Affairs patients 50 years of age or older with symptomatic knee OA. Current use of various CAM therapies was assessed at baseline. Logistic regression models were used to compare race and gender differences in the use of specific CAMs...
September 2021: ACR open rheumatology
#31
REVIEW
Anil Krishnamurthy, Adam Edward Lang, Sanjog Pangarkar, Jess Edison, John Cody, James Sall
In July 2020, the US Department of Veterans Affairs (VA) and US Department of Defense (DoD) approved a new joint clinical practice guideline for the non-surgical management of hip and knee osteoarthritis. This synopsis highlights some of the recommendations. In February 2019, the VA/DoD Evidence-Based Practice Work Group convened a joint VA/DoD guideline development effort that included clinical stakeholders and conformed to the National Academy of Medicine's tenets for trustworthy clinical practice guidelines...
September 2021: Mayo Clinic Proceedings
#32
JOURNAL ARTICLE
David B Ridley, Pranav Ganapathy, Hannah E Kettler
The COVID-19 global pandemic has devastated lives and economies. It has served as a reminder of how critical it is to invest in preventing and treating infectious diseases. Until the COVID-19 pandemic, the largest US government-sponsored reward for infectious disease drug and vaccine development was the Tropical Disease Priority Review Voucher program. Under this program, the Food and Drug Administration awards a priority review voucher to the sponsor of a new drug or vaccine for tropical infectious diseases...
August 2021: Health Affairs
#33
JOURNAL ARTICLE
Steven H Woodward, Andrea L Jamison, Sasha Gala, Catherine Lawlor, Diana Villasenor, Gisselle Tamayo, Melissa Puckett
Though popular across many audiences, engagement with a service dog has undergone limited empirical evaluation as a complementary or alternative treatment for posttraumatic stress disorder (PTSD). The present study took advantage of a service dog training intervention underway in a Department of Veterans Affairs residential PTSD treatment program to perform a within-subjects comparison of a range of phenotypic markers. The present report considers negative and positive affect, assessed throughout the day, contrasting weeks when participants were or were not accompanied by their service dog...
June 2021: Journal of Consulting and Clinical Psychology
#34
JOURNAL ARTICLE
Jolie N Haun, Jacquelyn Paykel, Christine Melillo
BACKGROUND: Complementary and integrative health (CIH) is the foundation of the Department of Veterans Affairs (VA) Whole Health System program (WH), including Transforming Health and Resiliency through Integration of Values-based Experiences (THRIVE). The global COVID-19 pandemic prompted an urgent need to provide services such as THRIVE while following guidelines for social distancing. OBJECTIVE: The objective of this paper was to describe the systematic implementation of THRIVE using an electronic delivery model...
June 29, 2021: JMIR Formative Research
#35
JOURNAL ARTICLE
Danielle M Dick, Trisha Saunders, Emily Balcke, Morgan N Driver, Zoe Neale, Jasmin Vassileva, Joshua M Langberg
Objective: Risky substance use among college students is widespread, and associated with numerous adverse consequences. Current interventions focus primarily on students' current substance use; we hypothesize that shifting focus from current use to underlying risk factors is a complementary approach that may improve effectiveness of prevention/intervention programming. This approach aligns with the personalized medicine movement, which aims to harness knowledge about underlying etiological factors to provide individuals with specific information about their unique risk profiles and personalized recommendations, to motivate and enable individuals to better self-regulate their health...
June 10, 2021: Psychology of Addictive Behaviors
#36
JOURNAL ARTICLE
Cynthia Mikolas, Hope Winfield, Lorraine Smith-MacDonald, Ashley Pike, Chelsea Jones, Melina Lee, Jennifer Griffiths, Ryan Perry, David M Olson, Alexandra Heber, Joanne Olson, Phillip R Sevigny, Suzette Brémault-Phillips
Introduction: A new vision of resilience and well-being for Canadian military service members (SMs), Veterans and their families has been championed by the Canadian Armed Forces (CAF) and Veterans Affairs Canada (VAC). Operationalizing this vision, which aims to support those who serve/have served and their families as they navigate life during and post-service, requires the support of service providers (SPs). Training SPs to deliver complementary resilience-training programs Reaching In… Reaching Out (RIRO; for adults working with parents of young children) and Bounce Back and Thrive! (BBT; for parents of children aged 0-8 years of age) may support this vision...
2021: Frontiers in Public Health
#37
JOURNAL ARTICLE
Gail Castañeda, Sergio Romero, Stephen Mudra, Ted Gingrich, Charles Levy
Objective: To assess provider perceptions regarding battlefield acupuncture (BFA) and integrative medicine at a single Veterans Health Administration facility. Materials and Methods: A total of 87 allopathic and osteopathic providers trained to provide BFA were invited to participate in a self-report web-based questionnaire assessing provider BFA perceptions and practice. Mixed methodology was used to analyze closed- and open-ended survey responses. Results: Sixty-six providers completed the survey. On average, most providers reported 3-4 BFA treatments per patient (43...
April 1, 2021: Medical Acupuncture
#38
JOURNAL ARTICLE
Jessica L Moreau, Alison B Hamilton, Elizabeth M Yano, Lisa V Rubenstein, Susan E Stockdale
While patient-centered care (PCC) is a widely accepted aspect of health-care quality, its definition is still the subject of debate. We investigated health-care workers' definitions of PCC by level of patient contact in job roles. Our qualitative study involved semi-structured interviews with key stakeholder employees (n = 66) at 6 Veterans' Affairs health-care locations in Southern California. Interviews were recorded, transcribed, coded for definitions of PCC, and analyzed by participants' self-described level of patient contact...
December 2020: Journal of Patient Experience
#39
JOURNAL ARTICLE
Brian Borsari, Yongmei Li, Jennifer Tighe, Jennifer K Manuel, N Simay Gökbayrak, Kevin Delucchi, Benjamin J Morasco, Linda Abadjian, Beth E Cohen, Catherine Baxley, Karen H Seal
BACKGROUND AND AIMS: Opioid use and chronic pain are prevalent in the veteran population. Collaborative Care enhances coordination between patients and their care teams and Motivational Interviewing (MI) is a communication style designed to facilitate behavior change. This study evaluated the use of Collaborative Care with MI (CCMI) with patients with chronic pain and high-risk prescription opioid use. DESIGN: Small pilot of a randomized controlled trial. SETTING: An urban Veterans Affairs (VA) Medical Center in the United States...
January 6, 2021: Addiction
#40
JOURNAL ARTICLE
Karen H Seal, William C Becker, Jennifer L Murphy, Natalie Purcell, Lauren M Denneson, Benjamin J Morasco, Aaron M Martin, Kavitha Reddy, Theresa Van Iseghem, Erin E Krebs, Jacob M Painter, Hildi Hagedorn, Jeffrey M Pyne, John Hixon, Shira Maguen, Thomas C Neylan, Brian Borsari, Beth DeRonne, Carolyn Gibson, Marianne S Matthias, Joseph W Frank, Akshaya Krishnaswamy, Yongmei Li, Daniel Bertenthal, Allan Chan, Alejandro Nunez, Nicole McCamish
BACKGROUND: The Whole Health model of the U.S. Department of Veterans Affairs (VA) emphasizes holistic self-care and multimodal approaches to improve pain, functioning, and quality of life. wHOPE (Whole Health Options and Pain Education) seeks to be the first multisite pragmatic trial to establish evidence for the VA Whole Health model for chronic pain care. DESIGN: wHOPE is a pragmatic randomized controlled trial comparing a Whole Health Team (WHT) approach to Primary Care Group Education (PC-GE); both will be compared to Usual VA Primary Care (UPC)...
December 12, 2020: Pain Medicine
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