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cordycepin

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https://www.readbyqxmd.com/read/28522898/the-protective-effect-of-cordycepin-on-d-galactosamine-lipopolysaccharide-induced-acute-liver-injury
#1
Jin Li, Liping Zhong, Haibo Zhu, Fengzhong Wang
As the major active ingredient of Cordyceps militaris, cordycepin (3'-deoxyadenosine) has been well documented to alleviate inflammation and oxidative stress both in vitro and in vivo. To explore the potential protective effect of cordycepin in fulminant hepatic failure, mice were pretreated with cordycepin for 3 weeks followed by D-galactosamine (GalN)/lipopolysaccharide (LPS) injection. Then we found cordycepin (200 mg/kg) administration elevated survival rate, improved liver function, and suppressed hepatocyte apoptosis and necrosis in mice with severe hepatic damage by GalN/LPS treatment...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28512574/crystallographic-and-saxs-studies-of-s-adenosyl-l-homocysteine-hydrolase-from-bradyrhizobium-elkanii
#2
Tomasz Manszewski, Kamil Szpotkowski, Mariusz Jaskolski
S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3'-deoxyadenosine), (ii) adenine (Ade), (iii) Ado and (iv) mixed 2'-deoxyadenosine (2'-dAdo) and Ade. The crystal structures were solved at resolutions of 1.84, 1.95, 1.95 and 1.54 Å, respectively. Only the Ade complex crystallized with a dimer in the asymmetric unit, while all of the other complexes formed a crystallographically independent tetrameric assembly...
May 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28512059/genome-scale-metabolic-network-of-cordyceps-militaris-useful-for-comparative-analysis-of-entomopathogenic-fungi
#3
Wanwipa Vongsangnak, Nachon Raethong, Warasinee Mujchariyakul, Nam Ninh Nguyen, Hon Wai Leong, Kobkul Laoteng
The first genome-scale metabolic network of Cordyceps militaris (iWV1170) was constructed representing its whole metabolisms, which consisted of 894 metabolites and 1,267 metabolic reactions across five compartments, including the plasma membrane, cytoplasm, mitochondria, peroxisome and extracellular space. The iWV1170 could be exploited to explain its phenotypes of growth ability, cordycepin and other metabolites production on various substrates. A high number of genes encoding extracellular enzymes for degradation of complex carbohydrates, lipids and proteins were existed in C...
May 13, 2017: Gene
https://www.readbyqxmd.com/read/28485210/cytotoxic-compounds-against-cancer-cells-from-bombyx-mori-inoculated-with-cordyceps-militaris
#4
Weitao Qiu, Jing Wu, Jae-Hoon Choi, Hirofumi Hirai, Hiroshi Nishida, Hirokazu Kawagishi
Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells.
June 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28438013/characterization-of-newly-bred-cordyceps-militaris-strains-for-higher-production-of-cordycepin-through-hplc-and-urp-pcr-analysis
#5
Hyun-Hee Lee, Naru Kang, Inmyoung Park, Jungwook Park, Inyoung Kim, Jieun Kim, Namgyu Kim, Jae-Yun Lee, Young-Su Seo
Cordyceps militaris, a member of Ascomycota, a mushroom referred to as caterpillar Dong-chung-ha-cho, is commercially valuable because of its high content of bioactive substances including cordycepin and its potential for artificial cultivation. Cordycepin (3'-deoxyadenosine) is highly associated with the pharmacological effects of C. militaris. C. militaris is heterothallic in that two mating type loci, idiomorph MAT1-1 and MAT1-2, exist discretely in two different spores. In this study, nine C. militaris strains were mated with each other to prepare new strains that produced a larger amount of cordycepin than the parent strains...
April 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28435352/development-of-high-cordycepin-producing-cordyceps-militaris-strains
#6
Naru Kang, Hyun-Hee Lee, Inmyoung Park, Young-Su Seo
Cordyceps militaris, known as Dong-Chong-Xia-Cao, produces the most cordycepin among Cordyceps species and can be cultured artificially. For these reasons, C. militaris is widely used as herb or functional food in the East Asia. In this study, we developed a new strain of C. militaris that produces higher cordycepin content than parent strains through mating-based sexual reproduction. Twenty parent strains were collected and identified as C. militaris based on internal trasncrived spacer and rDNA sequences...
March 2017: Mycobiology
https://www.readbyqxmd.com/read/28409381/dash-type-cryptochromes-regulate-fruiting-body-development-and-secondary-metabolism-differently-than-cmwc-1-in-the-fungus-cordyceps-militaris
#7
Fen Wang, Xinhua Song, Xiaoming Dong, Jiaojiao Zhang, Caihong Dong
Cryptochromes (CRYs) belong to the photolyase/cryptochrome flavoprotein family, which is widely distributed in all kingdoms. A phylogenetic analysis indicated that three Cordyceps militaris proteins [i.e., cryptochrome DASH (CmCRY-DASH), (6-4) photolyase, and cyclobutane pyrimidine dimer (CPD) class I photolyase] belong to separate fungal photolyase/cryptochrome subfamilies. CmCRY-DASH consists of DNA photolyase and flavin adenine dinucleotide-binding domains, with RGG repeats in a C-terminal extension. Considerably, more carotenoids and cordycepin accumulated in the ΔCmcry-DASH strain than in the wild-type or ΔCmwc-1 strains, indicating an inhibitory role for CmCRY-DASH in these biosynthetic pathways...
April 13, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28406456/metronomic-cordycepin-therapy-prolongs-survival-of-oral-cancer-bearing-mice-and-inhibits-epithelial-mesenchymal-transition
#8
Nai-Wen Su, Shu-Hua Wu, Chih-Wen Chi, Chung-Ji Liu, Tung-Hu Tsai, Yu-Jen Chen
Cordycepin (3'-deoxyadenosine) is a natural compound abundantly found in Cordyceps sinesis in natural and fermented sources. In this study, we examined the effects of cordycepin in a human oral squamous cell carcinoma (OSCC) xenograft model. Cordycepin was administered in a regular, low-dose and prolonged schedule metronomic therapy. Two doses of cordycepin (25 mg/kg, 50 mg/kg) were administrated five days a week for eight consecutive weeks. The tumor volumes were reduced and survival time was significantly prolonged from 30...
April 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28402715/protective-effect-of-cordycepin-on-experimental-testicular-ischemia-reperfusion-injury-in-rats
#9
Mehmet Hanifi Okur, Serkan Arslan, Bahattin Aydogdu, Hikmet Zeytun, Erol Basuguy, Mehmet Serif Arslan, Ibrahim Ibiloglu, Ibrahim Kaplan
OBJECTIVE: To investigate the role of cordycepin in testicular ischemia/reperfusion injury in rats. MATERIALS AND METHODS: Forty Wistar albino rats were randomly divided into four groups, as follows: group one, control (C); group two, torsion and ischemia (I); group three: detorsion with ischemia-reperfusion (IR); and group four, detorsion/cordycepin. The rats were then analyzed macromorphologically and histopathologically, and blood tests were performed. Specifically, the total oxidant status (TOS) and total antioxidant status (TAS) were determined, and malondialdehyde (MDA), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β levels were analyzed...
April 12, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28401330/cordycepin-confers-neuroprotection-in-mice-models-of-intracerebral-hemorrhage-via-suppressing-nlrp3-inflammasome-activation
#10
Yijun Cheng, Yongxu Wei, Wenlei Yang, Yaying Song, Hanbing Shang, Yu Cai, Zhebao Wu, Weiguo Zhao
Neuroinflammation has been recognized as a major contributor to brain injury caused by intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome acts as an important mediator of inflammatory response in various inflammation-related diseases including hemorrhagic insults. Cordycepin has recently been shown to possess anti-inflammatory effect; however, its role and the possible underlying mechanisms in ICH remain unclear. This study was designed to investigate the neuroprotective effect of cordycepin in mice models of ICH and to elucidate the underlying molecular mechanisms...
April 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28401001/cordycepin-induces-human-lung-cancer-cell-apoptosis-by-inhibiting-nitric-oxide-mediated-erk-slug-signaling-pathway
#11
Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, Jae-Hong Ko
Nitric oxide (NO) is an important signaling molecule and a component of the inflammatory cascade. Besides, it is also involved in tumorigenesis. Aberrant upregulation and activation of the ERK cascade by NO often leads to tumor cell development. However, the role of ERK inactivation induced by the negative regulation of NO during apoptosis is not completely understood. In this study, treatment of A549 and PC9 human lung adenocarcinoma cell lines with cordycepin led to a reduction in their viability. Analysis of the effect of cordycepin treatment on ERK/Slug signaling activity in the A549 cell line revealed that LPS-induced inflammatory microenvironments could stimulate the expression of TNF-α, CCL5, IL-1β, IL-6, IL-8 and upregulate NO, phospho-ERK (p-ERK), and Slug expression...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28363523/cordycepin-enriched-wib-801c-from-cordyceps-militaris-improves-functional-recovery-by-attenuating-blood-spinal-cord-barrier-disruption-after-spinal-cord-injury
#12
Jee Youn Lee, Hye Young Choi, Hyung Hwan Baik, Bong G Ju, Won-Ki Kim, Tae Young Yune
ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects. AIM OF THIS STUDY: In the present study, we examined whether WIB-801C, a standardized and cordycepin-enriched extract of caterpillar fungus (Cordyceps militaris), would attenuate blood-spinal cord barrier (BSCB) disruption by inhibiting matrix metalloprotease (MMP)-9 activity, leading to improvement of functional outcomes after spinal cord injury (SCI)...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28351780/cordycepin-negatively-modulates-lipopolysaccharide-induced-cytokine-production-by-up-regulation-of-heme-oxygenase-1
#13
Rui Qing, Zezhi Huang, Yufei Tang, Qingke Xiang, Fan Yang
AIMS: The present study is to investigate the effect of cordycepin on the expression of heme oxygenase-1 (HO-1) in lipopolysaccharide (LPS)-activated microphages, as well as its mechanism of action. METHODS: Mouse RAW264.7 cells were treated with different concentrations of cordycepin for 0-16h. Western blotting was used to determine the expression of HO-1 and the phosphorylation of c-Src and the p47(phox) subunit of NADPH oxidase. Intracellular reactive oxygen species (ROS) level was determined using H2DCFDA as fluorescent probe...
March 25, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28322150/a-novel-technique-for-rejuvenation-of-degenerated-caterpillar-medicinal-mushroom-cordyceps-militaris-ascomycetes-a-valued-traditional-chinese-medicine
#14
Anhui Chen, Yulong Wang, Ying Shao, Bo Huang
Cordyceps militaris has been used in traditional Chinese medicine for many years, but its frequent degeneration during continuous maintenance in culture can lead to substantial commercial losses. In this study, a degenerated strain of C. militaris was obtained by subculturing a wild-type strain through 10 successive subcultures. The relative abundance of the 2 mating types seems to be out of balance in the degenerated strain. By cross-mating 4 single-ascospore isolates (2 for MAT 1-1 and 2 for MAT 1-2) from the degenerated strain, we were able to restore fruiting body production to wild-type levels...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28317886/systems-pharmacology-based-strategy-to-screen-new-adjuvant-for-hepatitis-b-vaccine-from-traditional-chinese-medicine-ophiocordyceps-sinensis
#15
Jingbo Wang, Rui Liu, Baoxiu Liu, Yan Yang, Jun Xie, Naishuo Zhu
Adjuvants are common component for many vaccines but there are still few licensed for human use due to low efficiency or side effects. The present work adopted Systems Pharmacology analysis as a new strategy to screen adjuvants from traditional Chinese medicine. Ophiocordyceps sinensis has been used for many years in China and other Asian countries with many biological properties, but the pharmacological mechanism has not been fully elucidated. First in this study, 190 putative targets for 17 active compounds in Ophiocordyceps sinensis were retrieved and a systems pharmacology-based approach was applied to provide new insights into the pharmacological actions of the drug...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303227/analysis-of-cordyceps-by-multi-column-liquid-chromatography
#16
Zhengming Qian, Shaoping Li
Cordyceps is a famous traditional Chinese medicine (TCM) that has been used in China for hundreds of years. In the present study a multi-column liquid chromatography (MC-LC) system was developed for the qualitative analysis of macromolecules and micromolecules in Cordyceps. The MC-LC system includes a size exclusion pre-column, a size exclusion column (SEC) and a reversed phase column (RP) which were controlled by column-switching valves. The sample was separated by the size exclusion pre-column into two fractions (macromolecules and micromolecules)...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28266575/cordycepin-disrupts-leukemia-association-with-mesenchymal-stromal-cells-and-eliminates-leukemia-stem-cell-activity
#17
Shu-Man Liang, Yi-Jhu Lu, Bor-Sheng Ko, Yee-Jee Jan, Song-Kun Shyue, Shaw-Fang Yet, Jun-Yang Liou
Maintaining stemness of leukemic stem cells (LSCs) and reciprocal interactions between leukemia and stromal cells support leukemic progression and resistance to chemotherapy. Targeting the niche-based microenvironment is thus a new approach for leukemia therapy. Cordycepin is an analogue of adenosine and has been suggested to possess anti-leukemia properties. However, whether cordycepin influences association of leukemia and mesenchymal stromal cells has never been investigated. Here we show that cordycepin reduces CD34(+)CD38(-) cells in U937 and K562 cells and induces Dkk1 expression via autocrine and paracrine regulation in leukemia and mesenchymal stromal/stem cells (MSCs)...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219709/cordycepin-diminishes-thymic-stromal-lymphopoietin-induced-interleukin-13-production
#18
Myoung-Schook Yoou, Kyoung Wan Yoon, Youngjin Choi, Hyung-Min Kim, Hyun-Ja Jeong
Atopic dermatitis (AD) is known to aggravate by thymic stromal lymphopoietin (TSLP) and TSLP is also known to up-regulate mast cell proliferation via production of interleukin (IL)-13. Thus, we investigated whether cordycepin could regulate mast cell proliferation induced by TSLP in human mast cell line, HMC-1 cell. Cordycepin significantly diminished the production and mRNA of IL-13 through the down-regulation of phosphorylated-signal transducer and activation of transcription 6 in the TSLP-stimulated HMC-1 cells...
May 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28197639/cordycepin-induces-apoptosis-in-sgc%C3%A2-7901-cells-through-mitochondrial-extrinsic-phosphorylation-of-pi3k-akt-by-generating-ros
#19
Moussa Ide Nasser, Muqaddas Masood, Wei Wei, Xiaochun Li, Yifa Zhou, Bao Liu, Jiang Li, Xiaomeng Li
Medicinal plants are affluent sources of several effectual natural drugs. Among them cordycepin which is extracted from Cordyceps militaris is a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy of cordycepin in the context of human gastric cancer SGC‑7901 and searched for the cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis in SGC‑7901 cells with the help of regulating mitochondrial extrinsic pathways by inhibition of A3AR and drive activation of DR3, which promote the activation of PI3K/Akt protein expression as well as collapse of mitochondrial membrane potential (MMP)...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28119235/cordycepin-inhibits-airway-remodeling-in-a-rat-model-of-chronic-asthma
#20
Xia Fei, Xue Zhang, Guo-Qing Zhang, Wu-Ping Bao, Ying-Ying Zhang, Min Zhang, Xin Zhou
The potential suppression role of cordycepin (Cor) on airway remodeling in a rat model of chronic asthma was investigated in this paper. We evaluated the anti-remodeling of Cor (50mg/kg) combined with or without budesonide (BUD) and investigated the possible underlying molecular mechanisms. We found that Cor attenuated immunoglobulin (Ig) E, alleviated the airway wall thickness, and decreased eosinophils and neutrophils in the bronchoalveolar lavage fluid (BALF). Notably, Cor reduced the up-regulation of IL-5, IL-13 and TNF-α in the BALF...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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