keyword
MENU ▼
Read by QxMD icon Read
search

cordycepin

keyword
https://www.readbyqxmd.com/read/29139127/combined-transcriptome-and-translatome-analyses-reveal-a-role-for-tryptophan-dependent-auxin-biosynthesis-in-the-control-of-dog1-dependent-seed-dormancy
#1
Bing Bai, Ondřej Novák, Karin Ljung, Johannes Hanson, Leónie Bentsink
The importance of translational regulation during Arabidopsis seed germination has been shown previously. Here the role of transcriptional and translational regulation during seed imbibition of the very dormant DELAY OF GERMINATION 1 (DOG1) near-isogenic line was investigated. Polysome profiling was performed on dormant and after-ripened seeds imbibed for 6 and 24 h in water and in the transcription inhibitor cordycepin. Transcriptome and translatome changes were investigated. Ribosomal profiles of after-ripened seeds imbibed in cordycepin mimic those of dormant seeds...
November 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29124970/a-review-on-the-nucleic-acid-constituents-in-mushrooms-nucleobases-nucleosides-and-nucleotides
#2
Chia-Wei Phan, Joon-Keong Wang, Shiau-Chuen Cheah, Murali Naidu, Pamela David, Vikineswary Sabaratnam
Mushrooms have become increasingly important as a reliable food source. They have also been recognized as an important source of bioactive compounds of high nutritional and medicinal values. The nucleobases, nucleosides and nucleotides found in mushrooms play important roles in the regulation of various physiological processes in the human body via the purinergic and/or pyrimidine receptors. Cordycepin, a 3'-deoxyadenosine found in Cordyceps sinensis has received much attention as it possesses many medicinal values including anticancer properties...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29091925/insight-into-cordycepin-biosynthesis-of-cordyceps-militaris-comparison-between-a-liquid-surface-culture-and-a-submerged-culture-through-transcriptomic-analysis
#3
Ahmad Suparmin, Tatsuya Kato, Hideo Dohra, Enoch Y Park
Cordyceps militaris produces cordycepin, which is known to be a bioactive compound. Currently, cordycepin hyperproduction of C. militaris was carried out in a liquid surface culture because of its low productivity in a submerged culture, however the reason was not known. In this study, 4.92 g/L of cordycepin was produced at the 15th day of C. militaris NBRC 103752 liquid surface culture, but only 1 mg/L was produced in the submerged culture. RNA-Seq was used to clarify the gene expression profiles of the cordycepin biosynthetic pathways of the submerged culture and the liquid surface culture...
2017: PloS One
https://www.readbyqxmd.com/read/29090553/-simultaneous-determination-of-cordycepin-and-2-deoxyadenosine-in-cordyceps-genus-by-online-spe-hplc
#4
Ye Tian, Chuan-Xi Wang, Zheng-Ming Qian, Zhou Li, Miao-Xia Zhou, Wan-Yang Sun, Xin-Sheng Yao, Wen-Jia Li, Hao Gao
An online SPE-HPLC method for simultaneous determination of cordycepin (3'-deoxyadenosine) and 2'-deoxyadenosine in Cordyceps genus (C. sinensis,C. militaris,Hirsutella sinensis and C. sobolifera) was developed. The samples were enriched on a ZORBAX SB-AQ (4.6 mm×12.5 mm,5 μm) column with isocratic elution by 9% methanol solution. The separation of analytes was performed on a ZORBAX SB-AQ (4.6 mm×150 mm,5 μm) column with gradient elution by 0.1% formic acid solution and methanol (91∶9). The flow rate was 1...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29070781/cordycepin-induces-apoptotic-cell-death-and-inhibits-cell-migration-in-renal-cell-carcinoma-via-regulation-of-microrna-21-and-pten-phosphatase
#5
Chao Yang, Linlin Zhao, Weitang Yuan, Jianguo Wen
Cordycepin is an active component extracted from Traditional Chinese medical herb Cordyceps militaris. Many reports demonstrated that cordycepin harbors antitumor activity in a broad spectrum of cancer types. In this study the actions and the underneath molecular mechanisms of cordycepin were investigated in renal cell carcinoma Caki-1 cell line. Results showed that cordycepin induced apoptotic cell death and inhibited cell migration in Caki-1 cells. Quantitative real-time PCR results and western blot analyses indicated cordycepin dose-dependently decreased microRNA-21 expression and Akt phosphorylation levels in Caki-1 cells, but increased PTEN phosphatase levels...
2017: Biomedical Research
https://www.readbyqxmd.com/read/29056419/fungal-cordycepin-biosynthesis-is-coupled-with-the-production-of-the-safeguard-molecule-pentostatin
#6
Yongliang Xia, Feifei Luo, Yanfang Shang, Peilin Chen, Yuzhen Lu, Chengshu Wang
Cordycepin (COR) and pentostatin (PTN) are adenosine analogs with related bioactivity profiles as both mimic adenosine and can inhibit some of the processes that are adenosine dependent. Both COR and PTN are also natural products and were originally isolated from the fungus Cordyceps militaris and the bacterium Streptomyces antibioticus, respectively. Here, we report that not only is PTN produced by C. militaris but that biosynthesis of COR is coupled with PTN production by a single gene cluster. We also demonstrate that this coupling is an important point of metabolic regulation where PTN safeguards COR from deamination by inhibiting adenosine deaminase (ADA) activity...
September 27, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29054740/cordycepin-inhibits-lps-induced-acute-lung-injury-by-inhibiting-inflammation-and-oxidative-stress
#7
Jiaji Lei, Youlei Wei, Pengcheng Song, Yongchao Li, Tianze Zhang, Qingjiang Feng, Guangquan Xu
Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory effects of cordycepin on LPS-induced ALI remain unclear. Therefore, in the present study, we assessed whether cordycepin could attenuate ALI induced by LPS. The mice were conditioned with cordycepin 1h before intranasal instillation of LPS...
October 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29051060/treatment-with-3-deoxyadenosine-and-deoxycoformycin-in-mice-infected-by-trypanosoma-cruzi-and-its-side-effect-on-purinergic-enzymes
#8
Guilherme M do Carmo, Pedro H Doleski, Mariângela F de Sá, Thirssa H Grando, Maria I Azevedo, Alessandra G Manzoni, Daniela B R Leal, Lucas T Gressler, Luan C Henker, Ricardo E Mendes, Matheus D Baldissera, Silvia G Monteiro, Lenita M Stefani, Aleksandro S Da Silva
The aim of this study was to evaluate the efficacy of 3'-deoxyadenosine and deoxycoformycin combination in the treatment of mice infected by T. cruzi, as well as to verify the influence of the treatment on purinergic enzymes. Heart and serum samples were collected from 60 mice (30 infected and 30 uninfected) at day 12 post-infection. To verify treatment efficacy, parasitemia was monitored, and the treatment with 3'-deoxy adenosine and deoxycoformycin combination was able to reduce it, but had no curative effect on mice...
October 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29046704/lipolytic-effect-of-novel-extracts-from-mulberry-morus-alba-leaves-fermented-with-cordyceps-militaris-in-the-primary-adipocytes-derived-from-sd-rats
#9
Mi Rim Lee, Ji Eun Kim, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Whan Choi, Kyung Mi Kim, Dae Youn Hwang
Mulberry (Morus alba) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts of the mulberry leaves fermented with Cordyceps militaris (EMfCs) have not yet been identified. Therefore, the cAMP concentration and cell viability were measured in the primary adipocytes of SD (Sprague Dawley) rats and 3T3-L1 cells after treatment of 27 EMfCs. Briefly, mulberry leaves powders amended with three different concentrations (0, 25 and 50%) of silkworm pupae (SWP) powder were fermented with 10% C...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29045468/cordycepin-promotes-apoptosis-in-renal-carcinoma-cells-by-activating-the-mkk7-jnk-signaling-pathway-through-inhibition-of-c-flipl-expression
#10
In-Hu Hwang, Seung Yoon Oh, Hyun-Jin Jang, Eunbi Jo, Jong Cheon Joo, Kyung-Bok Lee, Hwa-Seung Yoo, Mi Young Lee, Soo Jung Park, Ik-Soon Jang
Cellular FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that associates with the signaling complex downstream of NF-κB, negatively interfering with apoptotic signaling. The role of c-FLIP downregulation by negative regulation of NF-κB signaling during apoptosis is poorly understood. Here, we demonstrate that NF-κB-mediated c-FLIPL negatively regulates the JNK signaling pathway, and that cordycepin treatment of human renal cancer cells leads to apoptosis induction through c-FLIPL inhibition...
2017: PloS One
https://www.readbyqxmd.com/read/29044404/a-new-cordycepin-producing-caterpillar-fungus-ophiocordyceps-xuefengensis-with-artificial-infection-to-the-host-cultivation-of-mycelia-and-stromata
#11
Jian Jin, Can Zhong, You Qin, Yuan Cai, Lanping Zhen, Bingbing Shen, Lin Chen, Dan Wan, Yuhui Qin, Shuihan Zhang
Caterpillar fungi have numerous pharmacological and therapeutic applications in traditional medicine, due to a variety of active chemical constituents, such as cordycepin and adenosine. It is imperative to discover new resource for artificial cultivation and biometabolite production since the traditional natural species are endangered. In this study, a new strain HACM 001 was isolated and identified as Ophiocordyceps xuefengensis by rDNA-ITS sequencing. This strain showed the potential of artificial infection to caterpillar larvae leading to mummification, as well as fermentation mycelia in liquid culture and cultivation stromata in solid medium...
November 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28987792/cordycepin-induces-apoptotic-cell-death-of-human-brain-cancer-through-the-modulation-of-autophagy
#12
Nipha Chaicharoenaudomrung, Thiranut Jaroonwitchawan, Parinya Noisa
Brain cancer, in particular neuroblastoma and glioblastoma, is a global challenge to human health. Cordycepin, extracted from Cordyceps ssp., has been revealed as a strong anticancer agent through several ways; however, the mechanism, by which cordycepin counteracts brain cancers, is still poorly understood. In this study, the underlying mechanisms of cordycepin against human brain cancer cells were explored. SH-SY5Y and U251 cells were being a model to represent human neuroblastoma and glioblastoma, respectively...
October 4, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28968944/anti-hepatocarcinoma-effect-of-cordycepin-against-ndea-induced-hepatocellular-carcinomas-via-the-pi3k-akt-mtor-and-nrf2-ho-1-nf-%C3%AE%C2%BAb-pathway-in-mice
#13
Yongming Zeng, Shuyi Lian, Danfeng Li, Xiaosheng Lin, Bozan Chen, Hongfa Wei, Tian Yang
The purpose of the present study was to evaluate the effects of cordycepin (CA) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinomas (HCC) and explore its potential mechanisms. Mice were randomly assigned to four groups: control group, NDEA group, NDEA+CA (20mg/kg) group, NDEA+CA (40mg/kg) group. The animal of each group were given NDEA (100ppm) in drinking water. One hour later, CA, which was dissolved in PBS, were intragastrically administered for continuous seven days. The results showed that CA reduced the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in liver and serum...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28962164/cordycepin-inhibits-vascular-adhesion-molecule-expression-in-tnf-%C3%AE-stimulated-vascular-muscle-cells
#14
Li-Jie Yan, Hai-Tao Yang, Hong-Yan Duan, Jin-Tao Wu, Peng Qian, Xian-Wei Fan, Shanling Wang
Atherosclerosis is a chronic inflammatory disease, which is associated with the increased expression of adhesion molecules in vascular smooth muscle cells (VSMCs). Cordycepin is one of the major bioactive components of Ophiocordyceps sinensis that has been demonstrated to exert anti-atherogenic activity; however, its molecular mechanisms are poorly understood. The aim of the present study was to examine the in vitro effects of cordycepin on the tumor necrosis factor (TNF)-α-induced suppression of adhesion molecule expression...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962083/cordycepin-inhibits-lps-induced-inflammatory-responses-by-modulating-nod-like-receptor-protein-3-inflammasome-activation
#15
Jing Yang, Yun-Zhou Li, Phillip B Hylemon, Lu-Yong Zhang, Hui-Ping Zhou
AIM: The aim of this study is to examine the effects of cordycepin (CRD) on LPS-induced inflammatory response in macrophages and further investigate the underlying molecular mechanisms. METHODS: Cultured mouse RAW264.7 macrophages and human THP-1-derived macrophages were used in this study. The mRNA and protein expression levels of cytokine IL-1β, IL-6, TNF-α, and MCP-1 were detected by real time RT-PCR, ELISA and Western blot, respectively. The activation of NOD-Like Receptor Protein 3 (NLRP3) inflammasome was analyzed with Western blot analysis and immunofluorescence staining...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28935392/transcriptome-analysis-of-paecilomyces-hepiali-at-different-growth-stages-and-culture-additives-to-reveal-putative-genes-in-cordycepin-biosynthesis
#16
Fang Pang, Linping Wang, Yu Jin, Lanping Guo, Lipu Song, Guiming Liu, Chengqiang Feng
Paecilomyces hepialid (PH) is an endoparasitic fungus of Cordyceps sinensis (CS) and has become a substitute for CS due to their similar pharmacological activities. Because the market demand for CS is difficult to satisfy, and cordycepin, the effective compound of CS, is difficult to industrially produce, we produced 5 samples of PH by culturing for different durations and adding different additives to the culture broth, and detected their cordycepin content with UPLC ESI MS/MS. Then we grouped these cultures into five transcriptome comparisons containing 3 time variable groups and 2 additive variable groups...
September 18, 2017: Genomics
https://www.readbyqxmd.com/read/28912858/cordycepin-induces-apoptosis-of-human-acute-monocytic-leukemia-cells-via-downregulation-of-the-erk-akt-signaling-pathway
#17
Yue Wang, Huimin Mo, Jun Gu, Kan Chen, Zhihua Han, Yi Liu
The aim of the present study was to examine the apoptotic effect of cordycepin (COR) on human THP-1 acute monocytic leukemia cells. THP-1 cells were exposed to different concentrations of COR for 24, 48, 72 or 96 h. The cell viability and apoptotic rate were analyzed. The gene expression of Akt1, Akt2, Akt3, B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) were assessed by reverse-transcription quantitative PCR. Western blot analysis was used to detect the protein levels of phosphorylated (p)-Akt, p-extracellular signal-regulated kinase (ERK) and cleaved caspase-3...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28911537/functional-study-of-cordyceps-sinensis-and-cordycepin-in-male-reproduction-a-review
#18
REVIEW
Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang
Cordyceps sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society. In this article, the in vitro and in vivo effects of C. sinensis and cordycepin on mouse Leydig cell steroidogenesis are briefly described, the stimulatory mechanisms are summarized, and the recent findings related to the alternative substances regulating male reproductive functions are also discussed.
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28895407/cordycepin-inhibits-cell-growth-and-induces-apoptosis-in-human-cholangiocarcinoma
#19
C Wang, Z P Mao, L Wang, F H Zhang, G H Wu, D Y Wang, J L Shi
The purpose of this study was to explore the role of cordycepin in human cholangiocarcinoma (CCA) cell growth and apoptosis. In the present study, colony formation assay, cell-counting kit-8 (CCK-8) assay and tumor xenograft experiment were performed to evaluate the effect of cordycepin on human CCA cell growth in vitro and in vivo; flow cytometric analysis was performed to evaluate the effect of cordycepin on cell apoptosis; quantitative real-time reverse transcription PCR (qRT-PCR) and western blot assays were performed to evaluate the expression levels of Caspase-3, Bcl-2 and Bax...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28891979/determination-of-the-main-nucleosides-and-nucleobases-in-natural-and-cultured-ophiocordyceps-xuefengensis
#20
Juan Zou, Ling Wu, Zheng-Mi He, Ping Zhang, Zuo-Hong Chen
Ophiocordyceps xuefengensis, a recently described species of Ophiocordycepsthat is associated with the larvae of Phassusnodus (Hepialidae) in the living root or trunk of the medicinal plant Clerodendrumcyrtophyllum, isthe largest known Cordycepsspecies and is recognized as a desirable alternative for natural Ophiocordycepssinensis. This study investigated the main nucleosides and nucleobases in natural and cultured Ophiocordycepsxuefengensis. The contents of the nucleosides and nucleobases in the natural and cultured samples were determined by reverse phase HPLC...
September 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
88030
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"