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cordycepin

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https://www.readbyqxmd.com/read/28912858/cordycepin-induces-apoptosis-of-human-acute-monocytic-leukemia-cells-via-downregulation-of-the-erk-akt-signaling-pathway
#1
Yue Wang, Huimin Mo, Jun Gu, Kan Chen, Zhihua Han, Yi Liu
The aim of the present study was to examine the apoptotic effect of cordycepin (COR) on human THP-1 acute monocytic leukemia cells. THP-1 cells were exposed to different concentrations of COR for 24, 48, 72 or 96 h. The cell viability and apoptotic rate were analyzed. The gene expression of Akt1, Akt2, Akt3, B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) were assessed by reverse-transcription quantitative PCR. Western blot analysis was used to detect the protein levels of phosphorylated (p)-Akt, p-extracellular signal-regulated kinase (ERK) and cleaved caspase-3...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28911537/functional-study-of-cordyceps-sinensis-and-cordycepin-in-male-reproduction-a-review
#2
REVIEW
Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang
Cordyceps sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society. In this article, the in vitro and in vivo effects of C. sinensis and cordycepin on mouse Leydig cell steroidogenesis are briefly described, the stimulatory mechanisms are summarized, and the recent findings related to the alternative substances regulating male reproductive functions are also discussed.
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28895407/cordycepin-inhibits-cell-growth-and-induces-apoptosis-in-human-cholangiocarcinoma
#3
C Wang, Z P Mao, L Wang, F H Zhang, G H Wu, D Y Wang, J L Shi
The purpose of this study was to explore the role of cordycepin in human cholangiocarcinoma (CCA) cell growth and apoptosis. In the present study, colony formation assay, cell-counting kit-8 (CCK-8) assay and tumor xenograft experiment were performed to evaluate the effect of cordycepin on human CCA cell growth in vitro and in vivo; flow cytometric analysis was performed to evaluate the effect of cordycepin on cell apoptosis; quantitative real-time reverse transcription PCR (qRT-PCR) and western blot assays were performed to evaluate the expression levels of Caspase-3, Bcl-2 and Bax...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28891979/determination-of-the-main-nucleosides-and-nucleobases-in-natural-and-cultured-ophiocordyceps-xuefengensis
#4
Juan Zou, Ling Wu, Zheng-Mi He, Ping Zhang, Zuo-Hong Chen
Ophiocordyceps xuefengensis, a recently described species of Ophiocordycepsthat is associated with the larvae of Phassusnodus (Hepialidae) in the living root or trunk of the medicinal plant Clerodendrumcyrtophyllum, isthe largest known Cordycepsspecies and is recognized as a desirable alternative for natural Ophiocordycepssinensis. This study investigated the main nucleosides and nucleobases in natural and cultured Ophiocordycepsxuefengensis. The contents of the nucleosides and nucleobases in the natural and cultured samples were determined by reverse phase HPLC...
September 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28882571/genome-shuffling-improved-the-nucleosides-production-in-cordyceps-kyushuensis
#5
Yanming Wang, Guoying Zhang, Xuan Zhao, Jianya Ling
Genome shuffling was first applied to improve the production of nucleosides in Cordyceps kyushuensis. Six improved strains were selected for genome shuffling by UV and HNO2 mutagenesis. Ten improved genome shuffling strains with good genetic stability were obtained, among which, the production of cordycepin in R6 was 9.624 times higher than that of the ancestor. While in R18 and R19, the yield of cordycepin, adenosine, guanosine and uridine were all increased greatly compared with the ancestor. Based on the four phenotypes of the content of cordycepin, adenosine, guanosine and uridine, hierarchical clustering analysis (HCA) and principal component analysis (PCA) were applied to infer the relationships between genome shuffling strains and mutants...
September 4, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28870956/targeted-delivery-of-cordycepin-to-liver-cancer-cells-using-transferrin-conjugated-liposomes
#6
Y E Bi, Yulin Zhou, Mengqiao Wang, Lianlian Li, Robert J Lee, Jing Xie, Lesheng Teng
BACKGROUND/AIM: Cordycepin is an endogenous nucleoside with significant anticancer biological activity. The objective of this study was to develop targeted liposomes to improve solubility and biological activity of cordycepin. MATERIALS AND METHODS: We established transferrin-conjugated liposomes to deliver cordycepin to liver cancer cells and evaluated the uptake and effect. RESULTS: The liposomes were loaded with cordycepin. Their average size was 125...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28762461/cordycepin-prevents-postoperative-formation-of-intra-abdominal-adhesion-in-a-rat-model-an-experimental-study
#7
Serkan Arslan, Hikmet Zeytun, Erol Basuguy, İbrahim İbiloğlu, İbrahim Uygun, Ahmet Yılmaz, İlhan Tan, Gülten Toprak
BACKGROUND: The aim of the present study was to investigate whether cordycepin prevented adhesion formation in a rat model. METHODS: Rats were randomly assigned to 3 groups of 10 rats. CONTROL GROUP: The absence of adhesion was confirmed via laparotomy. Adhesion group: The cecum was removed from the abdomen and scraped with a dry gauze bandage until petechial hemorrhagic foci developed. Cordycepin group: The same surgical procedure was performed as in the adhesion group, and 10 mg/kg cordycepin was administered intraperitoneally...
July 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28750234/identification-of-a-novel-component-leading-to-anti-tumor-activity-besides-the-major-ingredient-cordycepin-in-cordyceps-militaris-extract
#8
Takeharu Wada, I Wayan Sumardika, Shingo Saito, I Made Winarsa Ruma, Eisaku Kondo, Masami Shibukawa, Masakiyo Sakaguchi
In accordance with our previous study that was carried out to identify novel anti-tumor ingredients, chromatographic separation in combination with an anti-tumor activity assay was used for analysis of Cordyceps militaris extract in this study. Various modes of chromatography including reversed-phase, cation-exchange and anion-exchange were used to separate components of Cordyceps militaris, which showed various chemical properties. Anti-tumor activity of each fraction was assessed by a Hoechst staining-based apoptosis assay using malignant melanoma MeWo cells...
July 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28714368/cordycepin-induces-apoptosis-in-human-bladder-cancer-cells-via-activation-of-a3-adenosine-receptors
#9
Hong-Li Cao, Zi-Jin Liu, Zheng Chang
Bladder cancer is a neoplasm originated from bladder epithelial cells. The therapy for bladder cancer is so far not satisfactory. In this study, we examined the effects of Cordyceps militaris hot water extracts containing cordycepin on human bladder cells. Cordyceps militaris hot water extracts containing cordycepin was used to treat human T24 bladder carcinoma cells, and we found that Cordyceps militaris hot water extracts containing cordycepin decreased T24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of A3 adenosine receptor and the subsequent inactivation of Akt pathways, resulting in increases in cleaved Caspase-3 and apoptosis...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28662518/effects-of-n-nitrosodiethylamine-a-potent-carcinogen-on-sexual-development-gametogenesis-and-oocyte-maturation
#10
Reshma Nair U, Anju C Victor, Vinod Paul, Bindhu Paul-Prasanth
N-Nitrosodiethylamine (DEN), a well-known hepatocarcinogen, is found in certain food products as such or as a metabolic byproduct. This study investigated the effects of DEN on sexual development, gametogenesis, and oocyte maturation in Japanese medaka (Oryzias latipes). DEN reduced the germ cell number dose-dependently during early stages of sexual differentiation in XX larvae, resulting in underdeveloped ovaries in adulthood at low doses. This effect was sex-specific as no such changes were seen in XY larvae...
2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28636672/metabolomic-profile-and-nucleoside-composition-of-cordyceps-nidus-sp-nov-cordycipitaceae-a-new-source-of-active-compounds
#11
Juan Chiriví, Giovanna Danies, Rocio Sierra, Nicolas Schauer, Sandra Trenkamp, Silvia Restrepo, Tatiana Sanjuan
Cordyceps sensu lato is a genus of arthropod-pathogenic fungi, which have been used traditionally as medicinal in Asia. Within the genus, Ophiocordyceps sinensis is the most coveted and expensive species in China. Nevertheless, harvesting wild specimens has become a challenge given that natural populations of the fungus are decreasing and because large-scale culture of it has not yet been achieved. The worldwide demand for products derived from cultivable fungal species with medicinal properties has increased recently...
2017: PloS One
https://www.readbyqxmd.com/read/28605322/antioxidant-and-cholesterol-esterase-inhibitory-properties-of-supplementation-with-coconut-water-in-submerged-cultivation-of-the-medicinal-chinese-caterpillar-mushroom-ophiocordyceps-sinensis-cs1197-ascomycetes
#12
G M Shashidhar, S Sravan Kumar, P Giridhar, B Manohar
We investigated the potential use of coconut water to supplement potato dextrose broth (PDB) in the production of Ophiocordyceps sinensis CS1197 by submerged cultivation. The basal PDB medium was modified by supplementation with tender coconut water (TCW) and mature coconut water (MCW) at 10% and 5% (v/v), respectively; these mixtures were cultured at 28°C for 14 days, with a pH of 7 and an inoculum volume of 10%. The addition of optimized levels of TCW and MCW improved the biomass yield by 2.2- and 2.5-fold, respectively, and adenosine, cordycepin, and polysaccharide content by 58% and 69%, 50% and 55%, and 19% and 27%, respectively...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28594374/higher-anti-liver-fibrosis-effect-of-cordyceps-militaris-fermented-product-cultured-with-deep-ocean-water-via-inhibiting-proinflammatory-factors-and-fibrosis-related-factors-expressions
#13
Yu-Ping Hung, Chun-Lin Lee
Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective effects on the liver. In this study, the antiliver fibrosis effects and mechanisms of ultrapure water-cultured CM (UCM), DOW-cultured CM (DCM), synthetic water-cultured CM, DOW, cordycepin, and adenosine were compared in the liver fibrosis mice induced by intraperitoneal injections of thioacetamide (TAA)...
June 8, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28560504/development-of-cordycepin-formulations-for-preclinical-and-clinical-studies
#14
Jong Bong Lee, Cecilia Adrower, Chaolong Qin, Peter M Fischer, Cornelia H de Moor, Pavel Gershkovich
There is extensive literature on in vivo studies with cordycepin, but these studies were generally conducted without validation of the various formulations, especially in terms of the solubility of cordycepin in the dosing vehicles used. Cordycepin is a promising drug candidate in multiple therapeutic areas, and there is a growing interest in studies aimed at assessing the pharmacological activity of this compound in relevant animal disease models. It is likely that many reported in vivo studies used formulations in which cordycepin was incompletely soluble...
May 30, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28522898/the-protective-effect-of-cordycepin-on-d-galactosamine-lipopolysaccharide-induced-acute-liver-injury
#15
Jin Li, Liping Zhong, Haibo Zhu, Fengzhong Wang
As the major active ingredient of Cordyceps militaris, cordycepin (3'-deoxyadenosine) has been well documented to alleviate inflammation and oxidative stress both in vitro and in vivo. To explore the potential protective effect of cordycepin in fulminant hepatic failure, mice were pretreated with cordycepin for 3 weeks followed by D-galactosamine (GalN)/lipopolysaccharide (LPS) injection. Then we found cordycepin (200 mg/kg) administration elevated survival rate, improved liver function, and suppressed hepatocyte apoptosis and necrosis in mice with severe hepatic damage by GalN/LPS treatment...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28512574/crystallographic-and-saxs-studies-of-s-adenosyl-l-homocysteine-hydrolase-from-bradyrhizobium-elkanii
#16
Tomasz Manszewski, Kamil Szpotkowski, Mariusz Jaskolski
S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3'-deoxyadenosine), (ii) adenine (Ade), (iii) Ado and (iv) mixed 2'-deoxyadenosine (2'-dAdo) and Ade. The crystal structures were solved at resolutions of 1.84, 1.95, 1.95 and 1.54 Å, respectively. Only the Ade complex crystallized with a dimer in the asymmetric unit, while all of the other complexes formed a crystallographically independent tetrameric assembly...
May 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28512059/genome-scale-metabolic-network-of-cordyceps-militaris-useful-for-comparative-analysis-of-entomopathogenic-fungi
#17
Wanwipa Vongsangnak, Nachon Raethong, Warasinee Mujchariyakul, Nam Ninh Nguyen, Hon Wai Leong, Kobkul Laoteng
The first genome-scale metabolic network of Cordyceps militaris (iWV1170) was constructed representing its whole metabolisms, which consisted of 894 metabolites and 1,267 metabolic reactions across five compartments, including the plasma membrane, cytoplasm, mitochondria, peroxisome and extracellular space. The iWV1170 could be exploited to explain its phenotypes of growth ability, cordycepin and other metabolites production on various substrates. A high number of genes encoding extracellular enzymes for degradation of complex carbohydrates, lipids and proteins were existed in C...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28485210/cytotoxic-compounds-against-cancer-cells-from-bombyx-mori-inoculated-with-cordyceps-militaris
#18
Weitao Qiu, Jing Wu, Jae-Hoon Choi, Hirofumi Hirai, Hiroshi Nishida, Hirokazu Kawagishi
Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells.
June 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28438013/characterization-of-newly-bred-cordyceps-militaris-strains-for-higher-production-of-cordycepin-through-hplc-and-urp-pcr-analysis
#19
Hyun-Hee Lee, Naru Kang, Inmyoung Park, Jungwook Park, Inyoung Kim, Jieun Kim, Namgyu Kim, Jae-Yun Lee, Young-Su Seo
Cordyceps militaris, a member of Ascomycota, a mushroom referred to as caterpillar Dongchung-ha-cho, is commercially valuable because of its high content of bioactive substances, including cordycepin, and its potential for artificial cultivation. Cordycepin (3'-deoxyadenosine) is highly associated with the pharmacological effects of C. militaris. C. militaris is heterothallic in that two mating-type loci, idiomorph MAT1-1 and MAT1-2, exist discretely in two different spores. In this study, nine C. militaris strains were mated with each other to prepare newly bred strains that produced a larger amount of cordycepin than the parent strains...
July 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28435352/development-of-high-cordycepin-producing-cordyceps-militaris-strains
#20
Naru Kang, Hyun-Hee Lee, Inmyoung Park, Young-Su Seo
Cordyceps militaris, known as Dong-Chong-Xia-Cao, produces the most cordycepin among Cordyceps species and can be cultured artificially. For these reasons, C. militaris is widely used as herb or functional food in the East Asia. In this study, we developed a new strain of C. militaris that produces higher cordycepin content than parent strains through mating-based sexual reproduction. Twenty parent strains were collected and identified as C. militaris based on internal trasncrived spacer and rDNA sequences...
March 2017: Mycobiology
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