keyword
https://read.qxmd.com/read/38523002/low-level-ambient-ozone-exposure-associated-with-neutrophil-extracellular-traps-and-pro-atherothrombotic-biomarkers-in-healthy-adults
#21
JOURNAL ARTICLE
Hongbing Xu, Xinghou He, Bin Zhang, Mengyao Li, Yutong Zhu, Tong Wang, Shengcong Liu, Mushui Shu, Ding Ding, Yu Wang, Qian Zhao, Jianping Li, Xiaoming Song, Wei Huang
BACKGROUND AND AIMS: Uncertainty of the causality determinations for ambient ozone (O3 ) on cardiovascular events is heightened by the limited understanding of the mechanisms involved in humans. We aimed to examine the pro-atherothrombotic impacts of O3 exposure and to explore the potential mediating roles of dysfunctional neutrophils, focusing on neutrophil extracellular traps (NETs). METHODS: A longitudinal panel study of 152 healthy adults was conducted in the cool to cold months with relatively low levels of O3 between September 2019 and January 2020 in Beijing, China...
March 7, 2024: Atherosclerosis
https://read.qxmd.com/read/38522941/synthesis-of-ottonia-anisum-extract-mediated-zno-nps-and-their-local-anesthetic-analgesic-and-hcl%C3%A2-induced-acute-lung-injury-activities
#22
JOURNAL ARTICLE
Guiqin Fan, Jing Yu, Zhengzheng Tao, Xingjia Qian, Qinghong Qian, Jun Shu, Dongfang Shi, Luhong Shen, Bing Lu, Hong Lv
In this study, we outlined the green synthesis of Zinc oxide nanoparticles (ZnO NPs) using the plant-mediated method. Employing the nitrate derivative of Zinc and the extract from the native medicinal plant, Ottonia anisum, the nanoparticles were effectively produced. After obtaining a yellow-colored paste, it was meticulously dried, gathered, and set aside for subsequent examination. The UV-visible spectrometry analysis indicated an absorption peak at 320 nm, which is indicative of ZnO NPs. Characterization techniques, such as XRD and HR-TEM, confirmed the existence of agglomerated ZnO NPs with an average diameter of 40 nm...
March 25, 2024: Journal of Oleo Science
https://read.qxmd.com/read/38522826/nanoparticle-targeting-of-neutrophil-glycolysis-prevents-lung-ischemia-reperfusion-injury
#23
JOURNAL ARTICLE
Fuyi Liao, Davide Scozzi, Dequan Zhou, Mina Maksimos, Camila Diedrich, Marlene Cano, Laneshia K Tague, Zhyi Liu, Jeffrey A Haspel, Jennifer M Leonard, Wenjun Li, Alexander S Krupnick, Brian W Wong, Daniel Kreisel, Abdel Kareem Azab, Andrew E Gelman
Neutrophils exacerbate pulmonary ischemia-reperfusion injury (IRI) resulting in poor short and long-term outcomes for lung transplant recipients. Glycolysis powers neutrophil activation, but it remains unclear if neutrophil-specific targeting of this pathway will inhibit IRI. Lipid nanoparticles containing the glycolysis flux inhibitor 2-deoxyglucose (2-DG) were conjugated to neutrophil-specific Ly6G antibodies (NP-Ly6G(2-DG)). Intravenously administered NP-Ly6G(2-DG) to mice exhibited high specificity for circulating neutrophils...
March 22, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38522319/recent-advances-in-the-therapeutic-potential-of-nobiletin-against-respiratory-diseases
#24
REVIEW
Yanqin Qin, Jingfan Yang, Haibo Li, Jiansheng Li
BACKGROUND: Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role in respiratory diseases (RDs) treatment. OBJECTIVE: This review aimed to investigate the therapeutic potential of nobiletin against RDs, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension...
March 1, 2024: Phytomedicine
https://read.qxmd.com/read/38522285/emerging-application-of-nanomedicine-based-therapy-in-acute-respiratory-distress-syndrome
#25
REVIEW
Yitianhe Xu, Leyao Lv, Qian Wang, Qing Yao, Longfa Kou, Hailin Zhang
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious lung injuries caused by various factors, leading to increased permeability of the alveolar-capillary barrier, reduced stability of the alveoli, inflammatory response, and hypoxemia. Despite several decades of research since ARDS was first formally described in 1967, reliable clinical treatment options are still lacking. Currently, supportive therapy and mechanical ventilation are prioritized, and there is no medication that can be completely effective in clinical treatment...
March 21, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38521967/concurrent-abnormal-non-acid-reflux-is-associated-with-additional-chronic-rejection-risk-in-lung-transplant-patients-with-increased-acid-exposure
#26
JOURNAL ARTICLE
Wai-Kit Lo, Mayssan Muftah, Hilary J Goldberg, Nirmal Sharma, Walter W Chan
Acid reflux has been associated with allograft injury and rejection in lung transplant patients; however, the pathogenic role of non-acid reflux remains debated. We aimed to evaluate the impact of concurrent abnormal non-acid reflux with acid reflux on chronic rejection in lung transplant patients with acid reflux. This was a retrospective cohort study of lung transplant recipients who underwent pre-transplant combined impedance-pH study off acid suppression. Only subjects with acid exposure >4% were included...
March 23, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38521944/breath-metabolomics-for-diagnosis-of-acute-respiratory-distress-syndrome
#27
JOURNAL ARTICLE
Shiqi Zhang, Laura A Hagens, Nanon F L Heijnen, Marry R Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J Schultz, Dennis C J J Bergmans, Ronny M Schnabel, Lieuwe D J Bos
BACKGROUND: Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation. AIM: To evaluate the diagnostic accuracy of breath metabolites for ARDS in invasively ventilated intensive care unit (ICU) patients. METHODS: This two-center observational study included critically ill patients receiving invasive ventilation. Gas chromatography and mass spectrometry (GC-MS) was used to quantify the exhaled metabolites...
March 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38521771/ripk1-inhibitor-ameliorates-pulmonary-injury-by-modulating-the-function-of-neutrophils-and-vascular-endothelial-cells
#28
JOURNAL ARTICLE
Tao Yang, Cai-Gui Xiang, Xiao-Han Wang, Qing-Qing Li, Shu-Yue Lei, Kai-Rong Zhang, Jing Ren, Hui-Min Lu, Chun-Lan Feng, Wei Tang
Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention and supportive care are necessary. The pathophysiology of ALI is characterized by the disruption of the alveolar-capillary barrier and activation of neutrophils, leading to lung tissue damage. The receptor-interacting protein kinase 1 (RIPK1) has emerged as a promising target for the treatment of multiple inflammatory diseases, but the role of RIPK1 in the ALI remains poorly understood...
March 23, 2024: Cell Death Discovery
https://read.qxmd.com/read/38521412/crucial-role-played-by-ck8-cells-in-mediating-alveolar-injury-remodeling-for-patients-with-covid-19
#29
JOURNAL ARTICLE
Yufeng Li, Hengrui Hu, Jia Liu, Longda Ma, Xi Wang, Liang Liu, Qian Liu, Liang Ren, Jiang Li, Fei Deng, Zhihong Hu, Yiwu Zhou, Manli Wang
The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after injury. To address this concern, comparative and systematic analyses of SARS-CoV-2 infection in COVID-19 patients and animals were conducted. In the lungs of nine patients who died of COVID-19 and one recovered from COVID-19 but died of unrelated disease in early 2020, damage-related transient progenitor (DATP) cells expressing CK8 marker proliferated significantly...
March 21, 2024: Virologica Sinica
https://read.qxmd.com/read/38521298/structure-of-a-polysaccharide-mdp2-1-from-melastoma-dodecandrum-lour-and-its-anti-inflammatory-effects
#30
JOURNAL ARTICLE
Youying Tang, Mingyuan Zhou, Zian Mao, Bingqi Zhu, Fangmei Zhou, Xiaoqing Ye, Yuchi Chen, Zhishan Ding
The anti-inflammatory activity of polysaccharides derived from Melastoma dodecandrum Lour. was evaluated in pyretic mice and HEK-Blue™ hTLR4 cells. The testing led to the identification of MDP2-1, which was then investigated for its structural characteristics and anti-inflammatory effects. Results showed that MDP2-1 had a molecular weight of 29.234 kDa and primarily consisted of galactose, arabinose, rhamnose, glucose, glucuronic acid, and galacturonic acid. Its main backbone was composed of →4)-α-D-GalpA-(1→, →2)-α-L-Rhap-(1→, →3,4)-α-D-GalpA-(1→, →2,4)-α-D-GlcpA-(1→, and its side chains were connected by →4)-α-D-Galp-(1→, α-D-Galp-(1→, →4)-β-D-Glcp-(1→, and α-L-Araf-(1→...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38519984/recent-advances-in-the-potential-effects-of-natural-products-from-traditional-chinese-medicine-against-respiratory-diseases-targeting-ferroptosis
#31
REVIEW
Tian Chen, Lu Ding, Meiru Zhao, Siyu Song, Juan Hou, Xueyan Li, Min Li, Kai Yin, Xiangyan Li, Zeyu Wang
Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiotherapy, highlight the need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability to target multiple pathways and mechanisms. Active compounds from Chinese herbs and other natural sources exhibit anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects, making them valuable in preventing and treating respiratory conditions...
March 22, 2024: Chinese Medicine
https://read.qxmd.com/read/38519412/adverse-effects-of-microparticles-on-transfusion-of-stored-red-blood-cell-concentrates
#32
JOURNAL ARTICLE
Jie Yang, Yiming Yang, Li Gao, Xueyu Jiang, Juan Sun, Zhicheng Wang, Rufeng Xie
BACKGROUND: Systemic and pulmonary coagulopathy and inflammation are important characteristics of transfusion-related acute lung injury (TRALI). Whether microparticles that accumulate in transfused red blood cell concentrates (RBCs) have proinflammatory and procoagulant potential and contribute to adverse reactions of RBC transfusions is unclear. AIM: To investigate the ability of microparticles in stored RBCs to promote thrombin generation and induce human pulmonary microvascular endothelial cell (HMVEC) activation and damage...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38518980/regulatory-t-cells-supporting-lung-homeostasis-and-promoting-resolution-and-repair-after-lung-injury
#33
JOURNAL ARTICLE
Morgan J McCullough, Pria G Bose, Jason R Mock
Regulatory T cells, characterized by their expression of the transcription factor Forkhead box P3, are indispensable in maintaining immune homeostasis. The respiratory system is constantly exposed to many environmental challenges, making it susceptible to various insults and infections. Regulatory T cells play essential roles in maintaining homeostasis in the lung and promoting repair after injury. Regulatory T cell function dysregulation can lead to inflammation, tissue damage, or aberrant repair. Research on regulatory T cell mechanisms in the lung has unveiled their influence on lung inflammation and repair mechanisms...
March 20, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38518839/high-throughput-screening-of-respiratory-hazards-exploring-lung-surfactant-inhibition-with-20-benchmark-chemicals
#34
JOURNAL ARTICLE
James Y Liu, Ian C George, Saber Hussain, Christie M Sayes
As environmental air quality worsens and respiratory health injuries and diseases increase, it is essential to enhance our ability to develop better methods to identify potential hazards. One promising approach in emerging toxicology involves the utilization of lung surfactant as a model that addresses the limitations of conventional in vitro toxicology methods by incorporating the biophysical aspect of inhalation. This study employed a constrained drop surfactometer to assess 20 chemicals for potential surfactant inhibition...
March 20, 2024: Toxicology
https://read.qxmd.com/read/38518612/dysfunction-of-nrf2-regulated-cellular-defence-system-and-jnk-activation-induced-by-high-dose-of-fly-ash-particles-are-associated-with-pulmonary-injury-in-mouse-lungs
#35
JOURNAL ARTICLE
Jingwen Zhang, Kaihua Liu, Xiuwen Tang, Xiu Jun Wang
The mechanisms of the exposure to fine particulate matter (PM) as a risk factor for pulmonary injury are not fully understood. The transcription factor, NF-E2-related factor 2 (Nrf2), plays a key role in protection lung against PM insult and cancer chemoprevention. In this study, F3-S fly ash particles from a municipal waste incinerator were evaluated as a PM model. We found that F3-S triggered hierarchical oxidative stress responses involving the prolonged activation of the cytoprotective Nrf2 transcriptional program via Keap1 Cys151 modification, and c-Jun NH2-terminal kinase (JNK) phosphorylation at higher doses...
March 21, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38518606/inhibition-the-ubiquitination-of-enac-and-na-k-atpase-with-erythropoietin-promotes-alveolar-fluid-clearance-in-sepsis-induced-acute-respiratory-distress-syndrome
#36
JOURNAL ARTICLE
Ye Gao, Fei Cao, Xinyi Tian, Qianping Zhang, Congcong Xu, Bowen Ji, Ye-An Zhang, Linan Du, Jun Han, Li Li, Siyu Zhou, Yuqiang Gong, Binyu Ying, Fang Gao-Smith, Shengwei Jin
Sepsis-induced acute respiratory distress syndrome (ARDS) causes significant fatalities worldwide and lacks pharmacological intervention. Alveolar fluid clearance (AFC) plays a pivotal role in the remission of ARDS and is markedly impaired in the pathogenesis of ARDS. Here, we demonstrated that erythropoietin could effectively ameliorate lung injury manifestations and lethality, restore lung function and promote AFC in a rat model of lipopolysaccharide (LPS)-induced ARDS. Moreover, it was proven that EPO-induced restoration of AFC occurs through triggering the total protein expression of ENaC and Na,K-ATPase channels, enhancing their protein abundance in the membrane, and suppressing their ubiquitination for degeneration...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518597/intranasal-administration-of-escherichia-coli-nissle-expressing-the-spike-protein-of-sars-cov-2-induces-long-term-immunization-and-prevents-spike-protein-mediated-lung-injury-in-mice
#37
JOURNAL ARTICLE
Giovanni Sarnelli, Alessandro Del Re, Irene Palenca, Silvia Basili Franzin, Jie Lu, Luisa Seguella, Aurora Zilli, Marcella Pesce, Sara Rurgo, Giovanni Esposito, Walter Sanseverino, Giuseppe Esposito
While current anti-Spike protein (SP) vaccines have been pivotal in managing the pandemic, their limitations in delivery, storage, and the inability to provide mucosal immunization (preventing infections) highlight the ongoing necessity for research and innovation. To tackle these constraints, our research group developed a bacterial-based vaccine using a non-pathogenic E. coli Nissle 1917 (EcN) strain genetically modified to express the SARS-CoV-2 spike protein on its surface (EcN-pAIDA1-SP). We intranasally delivered the EcN-pAIDA1-SP in two doses and checked specific IgG/IgA production as well as the key immune mediators involved in the process...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518593/sp-8356-inhibits-acute-lung-injury-by-suppressing-inflammatory-cytokine-production-and-immune-cell-infiltration
#38
JOURNAL ARTICLE
Thai-Uy Nguyen, Sunghoon Hurh, Soyeon In, Lan Phuong Nguyen, Minyeong Cho, Kateryna Mykhailova, Hong-Rae Kim, Byung-Joo Ham, Yongseok Choi, Won-Ki Kim, Jong-Ik Hwang
This study investigated the anti-inflammatory and protective properties of SP-8356, a synthetic derivative of (1S)-(-)-verbenone, in a mouse model of LPS-induced acute lung injury (ALI). By targeting intracellular signaling pathways and inflammatory responses, SP-8356 demonstrated a potent ability to attenuate deleterious effects of proinflammatory stimuli. Specifically, SP-8356 effectively inhibited the activation of crucial signaling molecules such as NF-κB and Akt, and subsequently dampened the expression of inflammatory cytokines in various lung cellular components...
March 21, 2024: International Immunopharmacology
https://read.qxmd.com/read/38518569/pulmonary-fat-embolism-in-non-survivors-after-cardiopulmonary-resuscitation
#39
JOURNAL ARTICLE
Lucia Ihnát Rudinská, Patricie Delongová, Jana Vaculová, Silvia Farkašová Iannaccone, Lubomír Tulinský, Peter Ihnát
BACKGROUND: Blunt trauma acting against the human body presents the fundamental cause of pulmonary fat embolism (PFE) and fat embolism syndrome. The aim of the present study was to investigate PFE in non-survivors after cardiopulmonary resuscitation (CPR). METHODS: This was a prospective cohort study conducted in University Hospital Ostrava, Czech Republic. Within a 4-year study period, all non-survivors after CPR because of out-of-hospital cardiac arrest were assessed for the study eligibility...
March 18, 2024: Forensic Science International
https://read.qxmd.com/read/38517050/neutrophil-extracellular-traps-induce-pyroptosis-of-pulmonary-microvascular-endothelial-cells-by-activating-the-nlrp3-inflammasome
#40
JOURNAL ARTICLE
Peipei Zhao, Jiarui Zhu, Ling Bai, Wenlan Ma, Feifei Li, Cen Zhang, Liangtao Zhao, Liuyang Wang, Sigong Zhang
Excessive formation of neutrophil extracellular traps (NETs) may lead to myositis-related interstitial lung disease (ILD). There is evidence that NETs can directly injure vascular endothelial cells and play a pathogenic role in the inflammatory exudation of ILD. However, the specific mechanism is unclear. This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro...
March 22, 2024: Clinical and Experimental Immunology
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