keyword
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#1
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#2
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38534726/protective-effect-of-vitamin-k2-mk-7-on-acute-lung-injury-induced-by-lipopolysaccharide-in-mice
#3
JOURNAL ARTICLE
Weidong Yang, Yulian Wang, Lulu Liu, Lihong Liu, Shuzhuang Li, Yuyuan Li
Vitamin K2 (MK-7) has been shown to cause significant changes in different physiological processes and diseases, but its role in acute lung injury (ALI) is unclear. Therefore, in this study, we aimed to evaluate the protective effects of VK2 against LPS-induced ALI in mice. The male C57BL/6J mice were randomly divided into six groups (n = 7): the control group, LPS group, negative control group (LPS + Oil), positive control group (LPS + DEX), LPS + VK2 (L) group (VK2, 1.5 mg/kg), and LPS + VK2 (H) group (VK2, 15 mg/kg)...
February 22, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533500/alveolar-capillary-endocytosis-and-trafficking-in-acute-lung-injury-and-acute-respiratory-distress-syndrome
#4
REVIEW
Vitalii Kryvenko, István Vadász
Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality but lacks specific therapeutic options. Diverse endocytic processes play a key role in all phases of acute lung injury (ALI), including the initial insult, development of respiratory failure due to alveolar flooding, as a consequence of altered alveolar-capillary barrier function, as well as in the resolution or deleterious remodeling after injury. In particular, clathrin-, caveolae-, endophilin- and glycosylphosphatidyl inositol-anchored protein-mediated endocytosis, as well as, macropinocytosis and phagocytosis have been implicated in the setting of acute lung damage...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533306/the-noble-suicide-the-case-of-a-self-contained-dagger-in-the-heart-and-a-literal-raw
#5
Maricla Marrone, Benedetta Pia De Luca, Marco Papalino, Fortunato Pititto, Carlo Angeletti, Roberto Bellacicco, Michela Raino, Giuseppe Pulin, Francesca Tarantino
According to WHO estimates, more than 700,000 people die each year due to suicide and suicides performed with a bladed weapon account for approximately 1.6%-3% of all suicides. It is statistically more common to find injuries to the heart, lungs, and thoracic vessels in homicides, whereas in suicides there is a higher frequency of vascular injuries to the extremities of the limbs. Also in suicides, the presence of "hesitation marks," related to the attempts the victim makes before having the courage to kill himself, can often be found...
2024: Case Reports in Psychiatry
https://read.qxmd.com/read/38532147/prediction-of-short-and-long-term-outcomes-using-pre-operative-ventricular-size-in-infants-with-post-hemorrhagic-ventricular-dilation
#6
JOURNAL ARTICLE
Molly Serebin, Jian Zhang, Ke Yan, Erwin Cabacungan, Tejaswini Deshmukh, Mohit Maheshwari, Andrew Foy, Susan Cohen
PURPOSE: Post-hemorrhagic ventricular dilation (PHVD) leads to developmental delays in premature infants, yet the optimal timing of neurosurgical interventions is unknown. Neuroimaging modalities have emerged to delineate injury and follow the progression of PHVD. Fronto-temporal horn ratio (FTHR) is used as a marker of ventricular dilation and can be a standardized tool to direct the timing of neurosurgical intervention. Our study determined a pre-operative FTHR measurement threshold to predict short- and long-term outcomes...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38532125/elevated-alkaline-phosphatase-independently-predicts-early-postoperative-complications-in-noninfectious-revision-total-shoulder-arthroplasty
#7
JOURNAL ARTICLE
Steven H Liu, Christian J Leonardo, Rachel A Loyst, Patricia Cerri-Droz, Brandon Lung, Andrew Zhu, Edward D Wang
PURPOSE: This study investigates the association between preoperative serum alkaline phosphatase levels and 30 day postoperative complications following noninfectious revision total shoulder arthroplasty (TSA). We hypothesize that elevated alkaline phosphatase levels are significantly associated with an increased 30 day postoperative complication rate. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was queried for all patients who underwent noninfectious revision TSA from 2015 to 2022...
March 26, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38531959/longitudinal-long-term-follow-up-investigation-on-the-carcinogenic-impact-of-polyhexamethylene-guanidine-phosphate-in-rat-models
#8
JOURNAL ARTICLE
Sang Hoon Jeong, Hong Lee, Yoon Jeong Nam, Ja Young Kang, Hyejin Lee, Jin Young Choi, Yu-Seon Lee, Jaeyoung Kim, Yoon Hee Park, Su A Park, Hangseok Choi, Eun-Kee Park, Yong-Wook Baek, Jungyun Lim, Suejin Kim, Cherry Kim, Ju-Han Lee
Polyhexamethylene guanidine phosphate (PHMG-p) is a major component in humidifier disinfectants, which cause life-threatening lung injuries. However, to our knowledge, no published studies have investigated associations between PHMG-p dose and lung damage severity with long-term follow-up. Therefore, we evaluated longitudinal dose-dependent changes in lung injuries using repeated chest computed tomography (CT). Rats were exposed to low (0.2 mg/kg, n = 10), intermediate (1.0 mg/kg, n = 10), and high (5...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531534/comprehensive-assessment-of-risk-factors-and-pathogenic-characteristics-of-wound-infections-following-thoracoscopic-radical-resection-for-lung-cancer
#9
JOURNAL ARTICLE
Jian Xu, Jianhua Zhu
Lung cancer remains a leading cause of cancer-related mortality, with surgical resection as a primary treatment modality. However, postoperative wound infections (PWIs) pose significant risks following thoracoscopic radical resection. This study aims to identify the risk factors and pathogenetic characteristics associated with PWIs in lung cancer surgery. A comprehensive retrospective study was conducted from August 2021 to June 2023 at our institution. The study included 30 patients who developed PWIs and 60 controls who did not, following thoracoscopic radical resection for lung cancer...
April 2024: International Wound Journal
https://read.qxmd.com/read/38530369/igg-hexamers-initiate-complement-dependent-acute-lung-injury
#10
JOURNAL ARTICLE
Simon J Cleary, Yurim Seo, Jennifer J Tian, Nicholas Kwaan, David P Bulkley, Arthur E H Bentlage, Gestur Vidarsson, Éric Boilard, Rolf Spirig, James C Zimring, Mark R Looney
Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the complement cascade. A model for how IgG antibodies trigger complement activation involves interactions between IgG Fc domains driving assembly of IgG hexamer structures that activate C1 complexes. The importance of IgG hexamers in initiating injury responses was unclear, so we tested their relevance in a mouse model of alloantibody and complement-mediated acute lung injury...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38530103/prevalence-of-bacterial-codetection-and-outcomes-for-infants-intubated-for-respiratory-infections
#11
JOURNAL ARTICLE
Todd Karsies, Steven L Shein, Franco Diaz, Pablo Vasquez-Hoyos, Robin Alexander, Steven Pon, Sebastián González-Dambrauskas
OBJECTIVES: To determine the prevalence of respiratory bacterial codetection in children younger than 2 years intubated for acute lower respiratory tract infection (LRTI), primarily viral bronchiolitis, and identify the association of codetection with mechanical ventilation duration. DESIGN: Prospective observational study evaluating the prevalence of bacterial codetection (moderate/heavy growth of pathogenic bacterial plus moderate/many polymorphonuclear neutrophils) and the impact of codetection on invasive mechanical ventilation (IMV) duration...
March 26, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38529931/acute-kidney-injury-in-children-with-lymphoma
#12
JOURNAL ARTICLE
Hejia Zhang, Yanlong Duan, Xiaoxue Li, Zhi Chen, Xiaorong Liu
OBJECTIVE: To analyze the epidemiology of acute kidney injury (AKI) in children with lymphoma and to assess the incidence, risk profile of AKI, and effects on renal function in children with lymphoma during their first 30 days of hospitalization. MATERIALS AND METHODS: This was a retrospective screen of electronic hospital and laboratory databases to select hospitalized children who were first diagnosed and treated for lymphoma at Beijing Children's Hospital between 2020 and 2021...
March 26, 2024: Clinical Nephrology
https://read.qxmd.com/read/38529490/an-injury-induced-tissue-niche-shaped-by-mesenchymal-plasticity-coordinates-the-regenerative-and-disease-response-in-the-lung
#13
Dakota L Jones, Michael P Morley, Xinyuan Li, Yun Ying, Fabian L Cardenas-Diaz, Shanru Li, Su Zhou, Sarah E Schaefer, Ullas V Chembazhi, Ana Nottingham, Susan Lin, Edward Cantu, Joshua M Diamond, Maria C Basil, Andrew E Vaughan, Edward E Morrisey
Severe lung injury causes basal stem cells to migrate and outcompete alveolar stem cells resulting in dysplastic repair and a loss of gas exchange function. This "stem cell collision" is part of a multistep process that is now revealed to generate an i njury-induced t issue ni ch e (iTCH) containing Keratin 5+ epithelial cells and plastic Pdgfra+ mesenchymal cells. Temporal and spatial single cell analysis reveals that iTCHs are governed by mesenchymal proliferation and Notch signaling, which suppresses Wnt and Fgf signaling in iTCHs...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38529320/single-cell-analysis-of-lung-lymphatic-endothelial-cells-and-lymphatic-responses-during-influenza-infection
#14
JOURNAL ARTICLE
Jian Ge, Hongxia Shao, Hongxu Ding, Yuefeng Huang, Xuebing Wu, Jie Sun, Jianwen Que
Tissue lymphatic vessels network plays critical roles in immune surveillance and tissue homeostasis in response to pathogen invasion, but how lymphatic system per se is remolded during infection is less understood. Here, we observed that influenza infection induces a significant increase of lymphatic vessel numbers in the lung, accompanied with extensive proliferation of lymphatic endothelial cells (LECs). Single-cell RNA sequencing illustrated the heterogeneity of LECs, identifying a novel PD-L1+ subpopulation that is present during viral infection but not at steady state...
March 2024: J Respir Biol Transl Med
https://read.qxmd.com/read/38528524/respiratory-entrainment-related-reverse-triggering-in-mechanically-ventilated-children
#15
JOURNAL ARTICLE
Robert G T Blokpoel, Ruben B R Brandsema, Alette A Koopman, Jefta van Dijk, Martin C J Kneyber
BACKGROUND: The underlying pathophysiological pathways how reverse triggering is being caused are not fully understood. Respiratory entrainment may be one of these mechanisms, but both terms are used interchangeably. We sought to characterize reverse triggering and the relationship with respiratory entrainment among mechanically ventilated children with and without acute lung injury. METHODS: We performed a secondary phyiology analysis of two previously published data sets of invasively mechanically ventilated children < 18 years with and without lung injury mechanically ventilated in a continuous or intermittent mandatory ventilation mode...
March 25, 2024: Respiratory Research
https://read.qxmd.com/read/38527401/the-role-of-fpr2-mediated-ferroptosis-in-formyl-peptide-induced-acute-lung-injury-against-endothelial-barrier-damage-and-protective-effect-of-the-mitochondria-derived-peptide-mots-c
#16
JOURNAL ARTICLE
Ziang Wen, Jidan Fan, Faliang Zhan, Xiaopei Li, Ben Li, Peng Lu, Xin Yao, Zihao Shen, Zhaoyang Liu, Chufan Wang, Xiangyu Li, Wanjun Jin, Xiao Zhang, Yuanpu Qi, Xiaowei Wang, Meijuan Song
BACKGROUND: Acute lung injury (ALI) has garnered significant attention in the field of respiratory and critical care due to its high mortality and morbidity, and limited treatment options. The role of the endothelial barrier in the development of ALI is crucial. Several bacterial pathogenic factors, including the bacteria-derived formyl peptide (fMLP), have been implicated in damaging the endothelial barrier and initiating ALI. However, the mechanism by which fMLP causes ALI remains unclear...
March 24, 2024: International Immunopharmacology
https://read.qxmd.com/read/38524532/quantitative-proteome-and-lysine-succinylome-characterization-of-zinc-chloride-smoke-induced-lung-injury-in-mice
#17
JOURNAL ARTICLE
Rui Zhou, Zhiwei Tu, Daishi Chen, Wanmei Wang, Shuzi Liu, Linjun She, Zhan Li, Jihong Liu, Yabin Li, Yu Cui, Pan Pan, Fei Xie
The inhalation of zinc chloride (ZnCl2 ) smoke is one of common resources of lung injury, potentially resulting in severe pulmonary complications and even mortality. The influence of ZnCl2 smoke on lysine succinylation (Ksucc) in the lungs remains uncertain. In this study, we used a ZnCl2 smoke inhalation mouse model to perform global proteomic and lysine succinylome analyses. A total of 6781 Ksucc sites were identified in the lungs, with injured lungs demonstrating a reduction to approximately 2000 Ksucc sites, and 91 proteins exhibiting at least five differences in the number of Ksucc sites...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524361/trends-in-spinal-cancers-primary-metastatic-an-irish-epidemiological-perspective
#18
JOURNAL ARTICLE
Amanda O'Halloran, Christopher McKee, Gráinne Cunniffe, Seamus Morris
BACKGROUND: The incidence and histological type of spinal cancer is diverse. It is our role as physicians to explore the epidemiology of spinal cancers so that several projections can be made. Resource allocation, cost analyses, and the requirement of rehabilitation facilities all need to be considered.The objective of this paper is to provide an account of the acute spinal oncological admissions to the National Spinal Injuries Unit (NSIU) in both 2010 and 2020 with the hypothesis that upward trends will be noted...
August 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38523403/the-inhibition-of-marco-by-polyg-alleviates-pulmonary-fibrosis-via-regulating-mitochondrial-function-in-a-silicotic-rat-model
#19
JOURNAL ARTICLE
Meiyu Chang, Ning Li, Qiang Zhou, Yaomin Yan, Weiwei Xu, Yingzheng Zhao, Sanqiao Yao
Silicon dioxide (SiO2 )-induced pulmonary fibrosis is potentially associated with the impairment of mitochondrial function. Previous research found that inhibition of macrophage receptor with collagenous structure (MARCO) could alleviate particle-induced lung injury by regulating phagocytosis and mitigating mitochondrial damage. The present study aims to explore the underlying anti-fibrosis mechanism of polyguanylic acid (PolyG, MARCO inhibitor) in a silicotic rat model. Hematoxylin and eosin and Masson staining were performed to visualize lung tissue pathological changes...
March 24, 2024: Environmental Toxicology
https://read.qxmd.com/read/38523167/identification-of-non-coding-rna-signatures-in-idiopathic-pulmonary-fibrosis
#20
JOURNAL ARTICLE
Alperen Elek, Esra Bozgeyik, Halil Caska, Zekihan Gocer, Ibrahim Bozgeyik
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a deadly, chronic, progressive, irreversible interstitial lung disease characterized by the formation of scar tissue resulting in permanent lung damage. The average survival time following diagnosis is only 3-5 years, with a 5-year survival rate shorter than that of many cancers. Alveolar epithelial cell injury followed by irregular repair is the primary pathological process observed in patients with IPF. An evident characteristic of IPF is the development of fibroblastic foci representing active fibrotic areas...
March 25, 2024: Irish Journal of Medical Science
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